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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: DIO2 (NCBI Gene ID:1734)

Gene Summary

Gene Summary

Gene Information	Gene Name: DIO2
	Gene ID: 1734
	Gene Symbol	DIO2
	Gene ID	1734
	Gene Name	iodothyronine deiodinase 2
	Synonyms	5DII\|D2\|DIOII\|SelY\|TXDI2
	Cytomap	14q31.1
	Type of Gene	protein-coding
	Description	type II iodothyronine deiodinasedeiodinase, iodothyronine type IIdeiodinase-2deiodonase-2thyroxine deiodinase, type IItype 2 DItype 2 iodothyronine deiodinasetype-II 5'-deiodinasetype-II 5'deiodinase
	Modification date	20200313
	UniProtAcc	Q92813

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0006414	Translational elongation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	DIO2	GO:0042403	thyroid hormone metabolic process	19651899

Inferred gene age of translation factor.

Gene

Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25

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Translation Studies in PubMed

We searched PubMed using 'DIO2[title] AND translation [title] AND human.'

Gene	Title	PMID
DIO2	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000557010	80682314	80682493	3UTR-3UTR

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
KIRP	DIO2	1.91579966070365	0.000980085227638483
HNSC	DIO2	-1.03837900519137	1.63011400218238e-05
BRCA	DIO2	1.30249259220534	1.7498244905122e-06
KIRC	DIO2	1.46798091921338	3.24635122520647e-05

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
LAML	DIO2	0.013424565	0.037850011

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with DIO2 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
OV	IUPHAR	DIO2	MMP13	0.802439595	1.39E-70
OV	IUPHAR	DIO2	MMP11	0.827425709	1.15E-78
PAAD	Cell metabolism gene	DIO2	DCN	0.808824736	1.34E-43
PAAD	Cell metabolism gene	DIO2	LUM	0.842048728	2.10E-50
PAAD	CGC	DIO2	COL1A1	0.808027256	1.88E-43
PAAD	CGC	DIO2	CDH11	0.813547985	1.75E-44
PAAD	CGC	DIO2	COL3A1	0.846542781	1.91E-51
PAAD	IUPHAR	DIO2	MMP2	0.803257372	1.37E-42
PAAD	IUPHAR	DIO2	FAP	0.83809107	1.63E-49
PAAD	TSG	DIO2	DCN	0.808824736	1.34E-43
PAAD	TSG	DIO2	CDH11	0.813547985	1.75E-44
READ	Cell metabolism gene	DIO2	INHBA	0.800520599	1.22E-24
READ	CGC	DIO2	COL1A1	0.807114141	2.59E-25
READ	CGC	DIO2	PDGFRB	0.808071701	2.06E-25
READ	IUPHAR	DIO2	PDGFRB	0.808071701	2.06E-25
READ	IUPHAR	DIO2	ADAM12	0.809868887	1.33E-25
READ	Kinase	DIO2	PDGFRB	0.808071701	2.06E-25
READ	TSG	DIO2	SPARC	0.80128123	1.02E-24
UVM	CGC	DIO2	PDGFRA	0.816640089	2.63E-20
UVM	IUPHAR	DIO2	PDGFRA	0.816640089	2.63E-20
UVM	Kinase	DIO2	PDGFRA	0.816640089	2.63E-20

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KICH	DIO2	DIO3	2.99576565642388	0.000120222568511963
KIRP	DIO2	DIO3	2.11672991197554	0.000364991836249828
LUSC	DIO2	DIO3	-3.39926154636446	0.000431975220131112
HNSC	DIO2	USP33	1.09404357054929	0.00106627625814326
CHOL	DIO2	SULT1A2	-1.54326061874327	0.00390625
CHOL	DIO2	TTR	-1.33781880177829	0.00390625
KIRP	DIO2	USP33	-5.75683656759177	0.0044123362749815
KIRC	DIO2	TSHB	-2.83931231962483	0.00548982038267274
CHOL	DIO2	SULT1A1	-1.6256523627365	0.0078125
ESCA	DIO2	THRB	-2.58207684432232	0.009765625
STAD	DIO2	TSHB	-4.42014192400107	0.0174961371837677
LUAD	DIO2	SULT1A2	-1.67560869581388	1.18194396849693e-10
KICH	DIO2	USP33	-3.81516481070664	1.50799751281738e-05
COAD	DIO2	SULT1A1	-8.13251854208452	2.08616256713867e-07
LUSC	DIO2	WSB1	-4.32409763957443	2.12320631466825e-07
KIRC	DIO2	THRB	-5.31717980936568	2.17963255607325e-13
BRCA	DIO2	DIO3	-9.10179108134124	2.36049496314692e-13
KIRC	DIO2	USP33	-1.37457584099877	2.99791861549815e-08
LUAD	DIO2	SULT1A1	-4.42395170180941	5.46188198426923e-11
BRCA	DIO2	THRB	-1.34341941016428	8.78896784747736e-33
KIRP	DIO2	THRB	-3.42377329647708	9.31322574615479e-10

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with DIO2

USP33, USP20, DIO2, UBE2G1, WSB1, TCEB2, CUL5, TCEB1, RBX1, MARCH6, ELAVL1, UBE2J1, VCP, PSMD4, TRIM25, TOMM22, SYNJ2BP,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
DIO2	chr14	80669587	G	C	single_nucleotide_variant	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
DIO2	LUAD	chr14	80669342	80669342	G	T	Missense_Mutation	p.A171E	7
DIO2	ACC	chr14	80677760	80677760	A	-	Frame_Shift_Del	p.F19fs	7
DIO2	UCEC	chr14	80669277	80669277	C	T	Missense_Mutation	p.A229T	3
DIO2	PRAD	chr14	80677658	80677658	C	T	Missense_Mutation	p.R53H	3
DIO2	ESCA	chr14	80677773	80677773	G	T	Missense_Mutation	p.L15M	3
DIO2	ESCA	chr14	80669192	80669192	A	C	Missense_Mutation		2
DIO2	LUAD	chr14	80677676	80677676	G	T	Missense_Mutation	p.T47N	2
DIO2	HNSC	chr14	80669404	80669404	G	A	Missense_Mutation	p.S25F	2
DIO2	ESCA	chr14	80669483	80669483	A	G	Missense_Mutation		2
DIO2	SKCM	chr14	80669428	80669428	G	A	Splice_Site	p.P17_splice	2
DIO2	LUAD	chr14	80669079	80669079	C	A	Nonsense_Mutation	p.E259*	2
DIO2	LGG	chr14	80669148	80669148	G	C	Missense_Mutation		2
DIO2	SKCM	chr14	80669068	80669068	G	A	Silent	p.F262F	2
DIO2	ESCA	chr14	80677773	80677773	G	T	Missense_Mutation		2
DIO2	ESCA	chr14	80669418	80669418	G	T	Missense_Mutation		2
DIO2	STAD	chr14	80677629	80677629	C	T	Missense_Mutation	p.V63I	2
DIO2	UCEC	chr14	80669060	80669060	C	A	Missense_Mutation	p.R301I	2
DIO2	SKCM	chr14	80669111	80669111	G	A	Missense_Mutation	p.S248F	2
DIO2	PAAD	chr14	80669213	80669213	C	T	Missense_Mutation		2
DIO2	UCEC	chr14	80669113	80669113	G	T	Missense_Mutation	p.F283L	2
DIO2	BLCA	chr14	80677657	80677657	G	A	Silent	p.R53R	2
DIO2	LUAD	chr14	80677806	80677806	G	T	Missense_Mutation	p.L4I	2
DIO2	KIRC	chr14	80669073	80669073	T	A	Missense_Mutation	p.N261Y	2
DIO2	UCEC	chr14	80669165	80669165	A	G	Missense_Mutation	p.V266A	2
DIO2	LIHC	chr14	80669460	80669460	T	A	Missense_Mutation		2
DIO2	LUAD	chr14	80677807	80677807	G	T	Silent	p.I3I	2
DIO2	UCEC	chr14	80669200	80669200	G	A	Silent	p.N254	2
DIO2	LAML	chr14	79739147	79739147	C	T	Missense_Mutation	p.A190T	2
DIO2	UCEC	chr14	80669258	80669258	A	C	Missense_Mutation	p.L235R	2
DIO2	UCEC	chr14	80669266	80669266	C	A	Missense_Mutation	p.Q232H	2
DIO2	ESCA	chr14	80669483	80669483	A	G	Missense_Mutation	p.L124P	2
DIO2	UCEC	chr14	80669488	80669488	G	A	Silent	p.R158	2
DIO2	HNSC	chr14	80669361	80669361	G	A	Missense_Mutation	p.H165Y	1
DIO2	LUAD	chr14	80669291	80669291	T	A	Missense_Mutation	p.Q188L	1
DIO2	LUSC	chr14	80669493	80669493	C	A	Nonsense_Mutation	p.E157*	1
DIO2	TGCT	chr14	80669620	80669620	A	C	Silent	p.G78G	1
DIO2	BLCA	chr14	80677627	80677627	G	A	Silent		1
DIO2	LGG	chr14	80669274	80669274	C	T	Missense_Mutation	p.A194T	1
DIO2	READ	chr14	80677635	80677635	G	A	Missense_Mutation	p.R61C	1
DIO2	SKCM	chr14	80669289	80669289	C	T	Missense_Mutation	p.E189K	1
DIO2	LUAD	chr14	80669424	80669424	G	T	Missense_Mutation	p.R144S	1
DIO2	LUSC	chr14	80677661	80677661	C	A	Missense_Mutation	p.R52L	1
DIO2	THYM	chr14	80677757	80677757	G	T	Missense_Mutation		1
DIO2	BLCA	chr14	80669091	80669091	G	A	Missense_Mutation		1
DIO2	LGG	chr14	80669379	80669379	C	T	Nonsense_Mutation	p.W33*	1
DIO2	SKCM	chr14	80677678	80677678	G	A	Silent	p.S46S	1
DIO2	LUAD	chr14	80677673	80677673	C	T	Missense_Mutation	p.R48H	1
DIO2	HNSC	chr14	80669598	80669598	C	T	Missense_Mutation	p.V86M	1
DIO2	LUSC	chr14	80677628	80677628	A	T	Missense_Mutation	p.V63D	1
DIO2	THYM	chr14	80669161	80669161	G	A	Silent		1
DIO2	BLCA	chr14	80677657	80677657	G	A	Silent		1
DIO2	LUAD	chr14	80669222	80669222	A	T	Missense_Mutation	p.V211E	1
DIO2	SKCM	chr14	80669131	80669131	C	A	Silent	p.L241L	1
DIO2	HNSC	chr14	80669344	80669344	C	A	Missense_Mutation	p.W170C	1
DIO2	LUAD	chr14	80677693	80677693	C	A	Missense_Mutation	p.L41F	1
DIO2	LUSC	chr14	80669428	80669428	G	T	Silent	p.A178A	1
DIO2	BLCA	chr14	80677627	80677627	G	A	Silent	p.V63V	1
DIO2	LGG	chr14	80669274	80669274	C	T	Missense_Mutation		1
DIO2	SKCM	chr14	80669282	80669282	C	T	Missense_Mutation	p.R191Q	1
DIO2	HNSC	chr14	80677621	80677621	C	G	Missense_Mutation	p.K65N	1
DIO2	LUAD	chr14	80669370	80669370	C	A	Missense_Mutation	p.D162Y	1
DIO2	MESO	chr14	80669618	80669618	T	C	Missense_Mutation	p.E79G	1
DIO2	BLCA	chr14	80669091	80669091	G	A	Missense_Mutation	p.R255W	1
DIO2	LGG	chr14	80669379	80669379	C	T	Missense_Mutation		1
DIO2	ESCA	chr14	80669192	80669192	A	C	Missense_Mutation	p.I221R	1
DIO2	LUAD	chr14	80677716	80677716	G	T	Missense_Mutation	p.L34I	1
DIO2	STAD	chr14	80677662	80677662	G	A	Missense_Mutation	p.R52W	1
DIO2	HNSC	chr14	80669404	80669404	G	A	Silent	p.F150F	1
DIO2	LUAD	chr14	80669310	80669310	C	A	Missense_Mutation	p.V182L	1
DIO2	LIHC	chr14	80669145	80669145	T	C	Missense_Mutation		1
DIO2	SKCM	chr14	80669529	80669529	C	T	Missense_Mutation	p.G109R	1
DIO2	STAD	chr14	80669184	80669184	C	T	Missense_Mutation	p.G224R	1
DIO2	ESCA	chr14	80669418	80669418	G	T	Missense_Mutation	p.L146M	1
DIO2	LUAD	chr14	80677634	80677634	C	A	Missense_Mutation	p.R61L	1
DIO2	PAAD	chr14	80669239	80669239	C	T	Silent		1
DIO2	BRCA	chr14	80672615	80672619	TATAA	-	Frame_Shift_Del	p.Y96fs	1
DIO2	SKCM	chr14	80677621	80677621	C	T	Silent	p.K65K	1
DIO2	STAD	chr14	80669144	80669144	T	G	Missense_Mutation	p.K237T	1
DIO2	HNSC	chr14	80669344	80669344	C	A	Missense_Mutation		1
DIO2	KIRP	chr14	80669247	80669247	A	T	Missense_Mutation	p.S239T	1
DIO2	LUAD	chr14	80669252	80669252	C	A	Missense_Mutation	p.R201L	1
DIO2	PAAD	chr14	80669239	80669239	C	T	Silent	p.P205P	1
DIO2	COAD	chr14	80677723	80677723	G	T	Silent	p.V31V	1
DIO2	LIHC	chr14	80669204	80669204	T	C	Missense_Mutation		1
DIO2	SKCM	chr14	80669237	80669237	G	A	Missense_Mutation	p.P206L	1
DIO2	STAD	chr14	80669474	80669474	T	G	Missense_Mutation	p.N127T	1
DIO2	HNSC	chr14	80669361	80669361	G	A	Missense_Mutation		1
DIO2	LUAD	chr14	80669421	80669421	T	A	Nonsense_Mutation	p.K145*	1
DIO2	PAAD	chr14	80669213	80669213	C	T	Missense_Mutation	p.R214H	1
DIO2	ESCA	chr14	80669418	80669418	G	T	Missense_Mutation	p.N20K	1
DIO2	LIHC	chr14	80669214	80669214	G	-	Frame_Shift_Del		1
DIO2	SKCM	chr14	80669341	80669341	C	T	Missense_Mutation	p.R46Q	1
DIO2	LUAD	chr14	80677711	80677712	-	TCAA	Frame_Shift_Ins	p.T35fs	1
DIO2	STAD	chr14	80669227	80669227	T	G	Silent	p.R209R	1
DIO2	HNSC	chr14	80669404	80669404	G	A	Missense_Mutation		1
DIO2	LUAD	chr14	80669369	80669369	T	C	Missense_Mutation	p.D162G	1
DIO2	LGG	chr14	80669148	80669148	G	C	Missense_Mutation	p.Q236E	1
DIO2	LIHC	chr14	80672572	80672573	-	C	Splice_Site		1
DIO2	SKCM	chr14	80669401	80669401	G	A	Missense_Mutation	p.P26L	1
DIO2	LUAD	chr14	80677806	80677807	GG	TT	Missense_Mutation	p.L4I	1
DIO2	TGCT	chr14	80669580	80669580	T	C	Missense_Mutation		1
DIO2	HNSC	chr14	80669598	80669598	C	T	Missense_Mutation		1
DIO2	LUAD	chr14	80677658	80677658	C	G	Missense_Mutation	p.R53P	1
DIO2	LGG	chr14	80677716	80677716	G	A	Missense_Mutation	p.L34F	1
DIO2	PRAD	chr14	80677671	80677671	C	T	Missense_Mutation	p.G49R	1
DIO2	LIHC	chr14	80672638	80672638	A	-	Frame_Shift_Del	p.L89fs	1
DIO2	SKCM	chr14	80669140	80669140	A	G	Silent	p.I238I	1

Copy number variation (CNV) of DIO2
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across DIO2
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
4889	N/A	BI493955	ANO3	chr11	26294794	+	DIO2	chr14	80663873	+
103141	N/A	AY516525	DIO2	chr14	80674113	-	KTN1	chr14	56061023	+
96016	Non-Cancer	TCGA-IN-8462-11A	DIO2	chr14	80697244	-	NEBL	chr10	21101869	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
PCPG	DIO2	0.01423319148839	0.4
STAD	DIO2	0.0335054565876026	0.9
THCA	DIO2	0.0344557274588811	0.9

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
TGCT	DIO2	0.0132610703805459	0.38
KIRC	DIO2	3.64692265200441e-05	0.0011
KIRP	DIO2	0.0347627222369488	0.97
LGG	DIO2	0.00566674778439931	0.17
BRCA	DIO2	2.20960581132458e-10	7.3e-09
PRAD	DIO2	0.0393718430728539	1
CESC	DIO2	5.63178868466479e-06	0.00018

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0005586	Bipolar Disorder	1	PSYGENET
C0014175	Endometriosis	1	CTD_human
C0025500	Mesothelioma	1	CTD_human
C0269102	Endometrioma	1	CTD_human
C1510586	Autism Spectrum Disorders	1	CTD_human