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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: DRD2 (NCBI Gene ID:1813)

Gene Summary

Gene Summary

Gene Information	Gene Name: DRD2
	Gene ID: 1813
	Gene Symbol	DRD2
	Gene ID	1813
	Gene Name	dopamine receptor D2
	Synonyms	D2DR\|D2R
	Cytomap	11q23.2
	Type of Gene	protein-coding
	Description	D(2) dopamine receptordopamine D2 receptordopamine receptor D2 isoformseven transmembrane helix receptor
	Modification date	20200322
	UniProtAcc	P14416

Child GO biological process term(s) under GO:0006412

GO ID

GO term

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	DRD2	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	8666994\|26554819
Hgene	DRD2	GO:0034776	response to histamine	16839358
Hgene	DRD2	GO:0050482	arachidonic acid secretion	8301582
Hgene	DRD2	GO:0050709	negative regulation of protein secretion	16839358
Hgene	DRD2	GO:1900168	positive regulation of glial cell-derived neurotrophic factor secretion	23373701

Inferred gene age of translation factor.

Gene

Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25

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Translation Studies in PubMed

We searched PubMed using 'DRD2[title] AND translation [title] AND human.'

Gene	Title	PMID
DRD2	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000362072	113285096	113285183	In-frame
ENST00000542968	113285096	113285183	In-frame
ENST00000362072	113287584	113287721	Frame-shift
ENST00000542968	113287584	113287721	Frame-shift

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
BLCA	DRD2	1.49888943587482	0.0360679626464844

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type

Gene

Coefficient

Pvalue

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with DRD2 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	TF	DRD2	OLIG3	0.800386811	4.15E-11
PCPG	Cell metabolism gene	DRD2	ST8SIA3	0.80453974	9.95E-44
TGCT	Cell metabolism gene	DRD2	F7	0.802369599	2.41E-36
TGCT	Cell metabolism gene	DRD2	ACSS3	0.803821292	1.45E-36
TGCT	Cell metabolism gene	DRD2	APOB	0.827174755	2.19E-40
TGCT	Cell metabolism gene	DRD2	GPC3	0.840103313	9.34E-43
TGCT	CGC	DRD2	SOX21	0.805657215	7.59E-37
TGCT	CGC	DRD2	TMPRSS2	0.815865705	1.82E-38
TGCT	CGC	DRD2	GPC3	0.840103313	9.34E-43
TGCT	Epifactor	DRD2	FOXP4	0.854814234	1.00E-45
TGCT	IUPHAR	DRD2	F7	0.802369599	2.41E-36
TGCT	IUPHAR	DRD2	TMPRSS2	0.815865705	1.82E-38
TGCT	IUPHAR	DRD2	CRABP2	0.821438626	2.14E-39
TGCT	IUPHAR	DRD2	FZD7	0.829700095	7.84E-41
TGCT	IUPHAR	DRD2	GPC3	0.840103313	9.34E-43
TGCT	TF	DRD2	SOX21	0.805657215	7.59E-37
TGCT	TF	DRD2	HES1	0.816563251	1.40E-38
TGCT	TF	DRD2	FOXJ1	0.822563233	1.38E-39
TGCT	TF	DRD2	SOX11	0.825483902	4.33E-40
TGCT	TF	DRD2	FOXP4	0.854814234	1.00E-45
TGCT	TSG	DRD2	KRT19	0.817824353	8.64E-39
TGCT	TSG	DRD2	SOX11	0.825483902	4.33E-40
TGCT	TSG	DRD2	RASSF10	0.827474922	1.94E-40
TGCT	TSG	DRD2	GPC3	0.840103313	9.34E-43

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
LIHC	DRD2	OXTR	-1.01645459766853	0.0030410617618495
LUSC	DRD2	SLC6A3	-3.12170449437341	0.0059393237503163
LUAD	DRD2	SLC6A3	1.35821040201445	0.0182052890234661
CHOL	DRD2	SLC6A3	-3.71301830948578	0.02734375
READ	DRD2	OXTR	-2.72690279460166	0.03125
CHOL	DRD2	ADRBK1	-2.52615197893623	0.0390625
ESCA	DRD2	CNR1	-5.36400338891692	0.0419921875
STAD	DRD2	OXTR	-4.23763542445203	1.11940316855908e-05
LUAD	DRD2	NCS1	-1.19522284969406	1.16091444027929e-06
THCA	DRD2	SLC6A3	-4.06801636862211	1.52069486270417e-09
HNSC	DRD2	CNR1	1.40873007329526	1.52218387938774e-05
COAD	DRD2	GRIN2B	1.80389174602034	2.08616256713867e-06
HNSC	DRD2	NCS1	2.02754651281811	2.58819454757031e-09
COAD	DRD2	ADRBK1	1.18062515535212	2.69412994384766e-05
COAD	DRD2	OXTR	-3.65588278753781	2.98023223876954e-08
BRCA	DRD2	OXTR	-2.06886240513964	3.16590455320684e-24
LUAD	DRD2	ARRB2	-2.18932048497597	3.40660700589176e-10
KIRC	DRD2	CNR1	-3.65001880620317	3.42855815703237e-07
PRAD	DRD2	ADRBK1	1.67528629562553	3.88449147505731e-08
KIRC	DRD2	SLC6A3	3.07827681348267	5.00897740892013e-13
LUAD	DRD2	CNR1	-1.56681403042838	5.54313496971022e-09
PRAD	DRD2	NCS1	-2.28157460580476	5.56398320496822e-08
KICH	DRD2	OXTR	2.8670878292771	5.96046447753906e-07
KIRC	DRD2	GRIN2B	-4.92422068737674	6.24336886728621e-06
THCA	DRD2	NCS1	-1.50288732405395	8.72808232572309e-11

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with DRD2

CLIC6, ADORA2A, PPP1R9B, NCS1, EPB41L1, FLNA, KCNJ3, KCNJ6, KCNJ5, PAWR, CALM1, ARRB2, GNB5, EGFR, MSRA, COLEC12, WDR45, NDFIP1, PRKCB, NEFM, DRD2, SSTR2, TRPC1, TRPC4, TRPC5, VDAC2, DNM1, DNM2, RTN3, APH1A, GHITM, ZDHHC4, LPAR1, BCAP29, SYNGR2, TRAM1, YIPF3, CCKBR, ARL6IP6, SLC35B1, CERS1, ABCA2, SLC22A17, CLDND1, TTYH1, GPR37, WLS, GABBR1, SLC4A3, GRINA, ATP6V0A2, ARL1, ATP6V0C, BCAP31, BAI1, CALM3, CHPT1, SMIM7, CRELD1, GPR137, GPR56, GABBR2, GDPD2, CERS2, NDUFV1, PIGG, PLLP, LPPR3, PAQR6, RTN1, RTN4, RHBDD2, SPP1, SERINC3, SLC15A4, SLC6A1, TSPAN3, TSPAN7, TF, TMEM101, TMEM11, TMEM63A, TMEFF2, WFS1, OPRM1, HRH3, KBTBD7, KBTBD6, MDM2, CLTC, CAV1, SNX4, ANKRD28, FANCD2, PPP6R1, SKP2,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
DRD2	chr11	113281397	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
DRD2	chr11	113281433	C	T	single_nucleotide_variant	Likely_benign	not_specified	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
DRD2	chr11	113281476	C	T	single_nucleotide_variant	Likely_benign	Dystonia	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
DRD2	chr11	113281509	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
DRD2	chr11	113281521	G	A	single_nucleotide_variant	Likely_benign	Dystonia\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
DRD2	chr11	113281545	C	T	single_nucleotide_variant	Likely_benign	Dystonia	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
DRD2	chr11	113281553	C	T	single_nucleotide_variant	Benign	Dystonia	SO:0001583\|missense_variant	SO:0001583\|missense_variant
DRD2	chr11	113281638	C	T	single_nucleotide_variant	Likely_benign	Dystonia	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
DRD2	chr11	113281776	A	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
DRD2	chr11	113281816	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
DRD2	chr11	113281850	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
DRD2	chr11	113283213	A	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
DRD2	chr11	113283268	GC	G	Deletion	Likely_benign	Dystonia\|not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
DRD2	chr11	113283271	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
DRD2	chr11	113283320	G	T	single_nucleotide_variant	Uncertain_significance	Dystonia	SO:0001583\|missense_variant	SO:0001583\|missense_variant
DRD2	chr11	113283437	T	C	single_nucleotide_variant	Benign	Dystonia	SO:0001583\|missense_variant	SO:0001583\|missense_variant
DRD2	chr11	113283450	G	A	single_nucleotide_variant	Likely_benign	Dystonia	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
DRD2	chr11	113283459	G	A	single_nucleotide_variant	Benign/Likely_benign	Dystonia\|not_specified	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
DRD2	chr11	113283469	T	G	single_nucleotide_variant	Uncertain_significance	Dystonia\|none_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
DRD2	chr11	113283474	A	G	single_nucleotide_variant	Likely_benign	Dystonia	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
DRD2	chr11	113283477	A	G	single_nucleotide_variant	Benign	Dystonia\|not_specified\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
DRD2	chr11	113283484	G	C	single_nucleotide_variant	Benign	Dystonia\|not_specified\|not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
DRD2	chr11	113283486	C	T	single_nucleotide_variant	Benign	Dystonia\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
DRD2	chr11	113283488	G	A	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	Dystonia\|not_specified\|not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
DRD2	chr11	113283492	G	A	single_nucleotide_variant	Likely_benign	Dystonia	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
DRD2	chr11	113283513	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
DRD2	chr11	113283517	G	T	single_nucleotide_variant	Uncertain_significance	Dystonia	SO:0001583\|missense_variant	SO:0001583\|missense_variant
DRD2	chr11	113283536	G	A	single_nucleotide_variant	Uncertain_significance	Dystonia	SO:0001583\|missense_variant	SO:0001583\|missense_variant
DRD2	chr11	113283546	G	C	single_nucleotide_variant	Benign	Dystonia	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
DRD2	chr11	113283564	G	A	single_nucleotide_variant	Benign	Dystonia	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
DRD2	chr11	113283595	C	T	single_nucleotide_variant	Uncertain_significance	Dystonia	SO:0001583\|missense_variant	SO:0001583\|missense_variant
DRD2	chr11	113283596	G	A	single_nucleotide_variant	Uncertain_significance	Dystonia	SO:0001583\|missense_variant	SO:0001583\|missense_variant
DRD2	chr11	113283600	A	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
DRD2	chr11	113283680	T	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
DRD2	chr11	113283688	C	A	single_nucleotide_variant	Benign/Likely_benign	Dystonia\|not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
DRD2	chr11	113283800	C	CT	Duplication	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
DRD2	chr11	113285126	C	T	single_nucleotide_variant	Uncertain_significance	Dystonia	SO:0001583\|missense_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001627\|intron_variant
DRD2	chr11	113285166	G	A	single_nucleotide_variant	Benign	Dystonia	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant
DRD2	chr11	113285166	G	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant
DRD2	chr11	113285176	C	G	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001627\|intron_variant
DRD2	chr11	113285299	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
DRD2	chr11	113285309	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
DRD2	chr11	113285536	C	A	single_nucleotide_variant	Benign	Dystonia	SO:0001627\|intron_variant	SO:0001627\|intron_variant
DRD2	chr11	113285916	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
DRD2	chr11	113286008	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
DRD2	chr11	113286199	C	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
DRD2	chr11	113286330	T	C	single_nucleotide_variant	Uncertain_significance	Dystonia	SO:0001583\|missense_variant	SO:0001583\|missense_variant
DRD2	chr11	113286337	G	A	single_nucleotide_variant	Likely_benign	Dystonia	SO:0001627\|intron_variant	SO:0001627\|intron_variant
DRD2	chr11	113286490	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
DRD2	chr11	113286501	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
DRD2	chr11	113287511	G	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
DRD2	chr11	113287591	T	C	single_nucleotide_variant	Uncertain_significance	Dystonia	SO:0001583\|missense_variant	SO:0001583\|missense_variant
DRD2	chr11	113287601	G	A	single_nucleotide_variant	Benign	Dystonia\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
DRD2	chr11	113287657	C	T	single_nucleotide_variant	Uncertain_significance	Myoclonic_dystonia_11	SO:0001583\|missense_variant	SO:0001583\|missense_variant
DRD2	chr11	113287685	C	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
DRD2	chr11	113287694	C	T	single_nucleotide_variant	Benign/Likely_benign	Dystonia\|not_specified	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
DRD2	chr11	113288763	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
DRD2	chr11	113288784	C	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
DRD2	chr11	113288787	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
DRD2	chr11	113288849	C	T	single_nucleotide_variant	Uncertain_significance	Dystonia	SO:0001583\|missense_variant	SO:0001583\|missense_variant
DRD2	chr11	113289037	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
DRD2	chr11	113289066	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
DRD2	chr11	113289182	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
DRD2	chr11	113294898	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
DRD2	chr11	113294976	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
DRD2	chr11	113294998	T	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
DRD2	chr11	113295082	C	T	single_nucleotide_variant	Benign	Dystonia	SO:0001627\|intron_variant	SO:0001627\|intron_variant
DRD2	chr11	113295143	T	C	single_nucleotide_variant	Likely_benign	Dystonia\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
DRD2	chr11	113295183	G	A	single_nucleotide_variant	Likely_benign	Dystonia	SO:0001583\|missense_variant	SO:0001583\|missense_variant
DRD2	chr11	113295218	G	A	single_nucleotide_variant	Benign	Dystonia	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
DRD2	chr11	113295221	G	T	single_nucleotide_variant	Benign	Dystonia	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
DRD2	chr11	113295223	C	T	single_nucleotide_variant	Uncertain_significance	Dystonia	SO:0001583\|missense_variant	SO:0001583\|missense_variant
DRD2	chr11	113295242	G	A	single_nucleotide_variant	Benign	Dystonia\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
DRD2	chr11	113295296	G	A	single_nucleotide_variant	Benign	Dystonia	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
DRD2	chr11	113295305	G	A	single_nucleotide_variant	Likely_benign	Dystonia	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
DRD2	chr11	113295314	C	T	single_nucleotide_variant	Benign	Dystonia	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
DRD2	chr11	113295699	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
DRD2	chr11	113296274	A	G	single_nucleotide_variant	Benign	not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
DRD2	chr11	113346251	T	TG	Duplication	Benign	not_provided
DRD2	chr11	113346351	T	C	single_nucleotide_variant	Benign	not_specified
DRD2	chr11	113346955	A	G	single_nucleotide_variant	Benign	Dystonia

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
DRD2	SKCM	chr11	113287617	113287617	G	A	Missense_Mutation	p.S167F	5
DRD2	LUAD	chr11	113286152	113286152	A	T	Silent	p.A238A	5
DRD2	SKCM	chr11	113283333	113283333	C	T	Silent	p.R361R	5
DRD2	KIRP	chr11	113288847	113288847	C	T	Silent	p.E99E	4
DRD2	UCEC	chr11	113295287	113295287	C	T	Silent	p.A29	4
DRD2	KIRP	chr11	113295344	113295344	A	G	Silent	p.D10D	4
DRD2	BLCA	chr11	113286216	113286216	C	T	Missense_Mutation	p.R217H	3
DRD2	SKCM	chr11	113286217	113286217	G	A	Missense_Mutation	p.R217C	3
DRD2	SKCM	chr11	113288760	113288760	G	A	Silent	p.I128I	3
DRD2	SKCM	chr11	113295194	113295194	G	A	Silent	p.S60S	3
DRD2	LUAD	chr11	113295259	113295259	T	A	Missense_Mutation	p.T39S	3
DRD2	COAD	chr11	113288814	113288814	G	A	Silent	p.F110F	3
DRD2	SKCM	chr11	113283578	113283578	C	T	Missense_Mutation	p.E280K	3
DRD2	LUAD	chr11	113286252	113286252	G	T	Missense_Mutation	p.T205N	3
DRD2	PAAD	chr11	113295218	113295218	G	A	Silent	p.N52N	3
DRD2	PAAD	chr11	113281506	113281506	G	T	Silent	p.I425I	3
DRD2	UCS	chr11	113285165	113285165	C	T	Missense_Mutation	p.E248K	3
DRD2	PAAD	chr11	113281640	113281640	C	T	Missense_Mutation	p.V381M	3
DRD2	BRCA	chr11	113286299	113286299	G	A	Silent	p.F189	3
DRD2	SKCM	chr11	113283288	113283288	G	A	Silent	p.A376A	3
DRD2	BRCA	chr11	113295308	113295308	G	T	Missense_Mutation	p.F22L	3
DRD2	SKCM	chr11	113286201	113286201	C	T	Missense_Mutation	p.R222Q	3
DRD2	CESC	chr11	113283477	113283477	A	G	Silent		2
DRD2	HNSC	chr11	113281596	113281596	C	T	Silent	p.L395L	2
DRD2	UCEC	chr11	113286177	113286177	C	T	Missense_Mutation	p.R230Q	2
DRD2	LUAD	chr11	113283382	113283382	G	T	Missense_Mutation	p.T345N	2
DRD2	SKCM	chr11	113283325	113283325	G	A	Missense_Mutation	p.S364F	2
DRD2	STAD	chr11	113287588	113287588	C	T	Missense_Mutation	p.A177T	2
DRD2	LAML	chr11	112788535	112788535	G	A	Missense_Mutation	p.S364F	2
DRD2	LUAD	chr11	113281557	113281557	G	T	Nonsense_Mutation	p.Y408*	2
DRD2	LUAD	chr11	113285168	113285168	G	T	Missense_Mutation	p.P247T	2
DRD2	UCEC	chr11	113287600	113287600	C	T	Missense_Mutation	p.G173R	2
DRD2	ESCA	chr11	113286268	113286268	C	T	Missense_Mutation	p.V200M	2
DRD2	SARC	chr11	113283521	113283521	G	A	Missense_Mutation		2
DRD2	SKCM	chr11	113295295	113295295	C	T	Missense_Mutation	p.G27R	2
DRD2	STAD	chr11	113295233	113295233	G	T	Silent	p.V47V	2
DRD2	UCEC	chr11	113287604	113287604	G	C	Silent	p.L171	2
DRD2	LUAD	chr11	113285167	113285167	G	T	Missense_Mutation	p.P247H	2
DRD2	HNSC	chr11	113295162	113295162	T	A	Missense_Mutation	p.Y71F	2
DRD2	SARC	chr11	113295128	113295128	G	A	Silent		2
DRD2	LIHC	chr11	113281601	113281601	T	C	Missense_Mutation		2
DRD2	STAD	chr11	113283448	113283448	G	A	Missense_Mutation	p.A323V	2
DRD2	UCEC	chr11	113288842	113288842	T	G	Missense_Mutation	p.K101T	2
DRD2	SKCM	chr11	113281570	113281570	G	A	Missense_Mutation	p.P404L	2
DRD2	ESCA	chr11	113283425	113283425	C	G	Missense_Mutation		2
DRD2	LUAD	chr11	113283453	113283453	G	T	Missense_Mutation	p.S321R	2
DRD2	LIHC	chr11	113288785	113288785	G	A	Missense_Mutation	p.A120V	2
DRD2	SKCM	chr11	113295249	113295249	G	A	Missense_Mutation	p.T42I	2
DRD2	UCEC	chr11	113295261	113295261	G	A	Missense_Mutation	p.A38V	2
DRD2	PAAD	chr11	113281506	113281506	G	T	Silent		2
DRD2	LUAD	chr11	113283469	113283469	T	G	Missense_Mutation	p.H316P	2
DRD2	LIHC	chr11	113281601	113281601	T	C	Missense_Mutation	p.I394V	2
DRD2	SKCM	chr11	113286151	113286151	G	A	Missense_Mutation	p.P239S	2
DRD2	UCEC	chr11	113295273	113295273	T	C	Missense_Mutation	p.Y34C	2
DRD2	LUAD	chr11	113285099	113285099	C	G	Missense_Mutation	p.V270L	2
DRD2	PAAD	chr11	113295218	113295218	G	A	Silent		2
DRD2	SKCM	chr11	113281467	113281467	C	T	Silent	p.L438L	2
DRD2	STAD	chr11	113286183	113286183	C	T	Missense_Mutation		2
DRD2	LUAD	chr11	113281511	113281511	T	C	Missense_Mutation	p.I424V	2
DRD2	BLCA	chr11	113286260	113286260	G	A	Silent	p.F202F	2
DRD2	SKCM	chr11	113285125	113285125	C	T	Missense_Mutation	p.G261E	2
DRD2	STAD	chr11	113286183	113286183	C	T	Missense_Mutation	p.S228N	2
DRD2	LUAD	chr11	113288792	113288792	A	G	Missense_Mutation	p.C118R	2
DRD2	UCEC	chr11	113283486	113283486	C	T	Silent	p.P310	2
DRD2	COAD	chr11	113295289	113295289	C	T	Missense_Mutation	p.A29T	2
DRD2	SKCM	chr11	113283384	113283384	C	T	Silent	p.Q344Q	2
DRD2	STAD	chr11	113295153	113295153	A	T	Missense_Mutation	p.V74D	2
DRD2	BLCA	chr11	113283459	113283459	G	A	Silent		2
DRD2	ESCA	chr11	113283425	113283425	C	G	Missense_Mutation	p.A331P	2
DRD2	BRCA	chr11	113283314	113283314	C	G	Missense_Mutation	p.E368Q	2
DRD2	UCEC	chr11	113283547	113283547	G	A	Missense_Mutation	p.P290L	2
DRD2	SKCM	chr11	113286233	113286233	C	T	Silent	p.K211K	2
DRD2	SKCM	chr11	113281470	113281470	G	A	Silent	p.F437F	2
DRD2	STAD	chr11	113295322	113295322	A	G	Missense_Mutation	p.W18R	2
DRD2	LUAD	chr11	113287642	113287642	C	G	Missense_Mutation	p.V159L	2
DRD2	LUAD	chr11	113295192	113295192	C	T	Missense_Mutation	p.R61H	2
DRD2	UCEC	chr11	113285101	113285101	C	A	Missense_Mutation	p.R269I	2
DRD2	PRAD	chr11	113295366	113295366	G	A	Missense_Mutation	p.P3L	2
DRD2	SKCM	chr11	113281576	113281576	T	C	Missense_Mutation	p.N402S	2
DRD2	STAD	chr11	113281585	113281585	C	G	Missense_Mutation	p.C399S	2
DRD2	LAML	chr11	112786851	112786851	G	A	Silent	p.G380	2
DRD2	LUAD	chr11	113286302	113286302	G	T	Silent	p.A188A	2
DRD2	HNSC	chr11	113283362	113283362	G	A	Missense_Mutation	p.R352W	2
DRD2	UCEC	chr11	113285104	113285104	C	T	Missense_Mutation	p.R268Q	2
DRD2	SKCM	chr11	113286265	113286265	G	A	Missense_Mutation	p.P201S	2
DRD2	STAD	chr11	113295137	113295137	G	A	Silent	p.A79A	2
DRD2	LAML	chr11	112792868	112792868	G	A	Silent	p.T153	2
DRD2	LUAD	chr11	113295303	113295303	C	A	Missense_Mutation	p.G24V	1
DRD2	MESO	chr11	113283324	113283324	G	T	Silent		1
DRD2	SKCM	chr11	113281632	113281632	G	A	Silent	p.I383I	1
DRD2	THYM	chr11	113283425	113283425	C	T	Missense_Mutation	p.A331T	1
DRD2	ESCA	chr11	113285184	113285184	C	A	Splice_Site	e5-1	1
DRD2	SARC	chr11	113283448	113283448	G	T	Missense_Mutation		1
DRD2	SKCM	chr11	113286145	113286145	T	C	Missense_Mutation	p.K241E	1
DRD2	GBM	chr11	113286210	113286210	C	T	Missense_Mutation		1
DRD2	OV	chr11	112791426	112791426	C	T	Missense_Mutation	p.R217H	1
DRD2	THYM	chr11	113283412	113283412	G	A	Missense_Mutation	p.P335L	1
DRD2	CESC	chr11	113283564	113283564	G	C	Silent		1
DRD2	HNSC	chr11	113283503	113283503	G	A	Silent	p.L305L	1
DRD2	SKCM	chr11	113295250	113295250	T	G	Missense_Mutation	p.T42P	1
DRD2	BLCA	chr11	113285116	113285116	G	T	Missense_Mutation		1
DRD2	LUAD	chr11	113286297	113286297	A	T	Missense_Mutation	p.V190E	1
DRD2	BLCA	chr11	113295338	113295338	A	C	Missense_Mutation	p.D12E	1
DRD2	HNSC	chr11	113283362	113283362	G	A	Missense_Mutation		1
DRD2	LIHC	chr11	113286289	113286289	A	G	Missense_Mutation		1
DRD2	OV	chr11	112800319	112800319	G	A	Missense_Mutation	p.P89S	1
DRD2	SKCM	chr11	113283291	113283291	G	A	Silent	p.L375L	1
DRD2	THYM	chr11	113286187	113286187	G	T	Missense_Mutation	p.R227S	1
DRD2	CESC	chr11	113283564	113283564	G	C	Silent	p.L286	1
DRD2	SKCM	chr11	113295242	113295242	G	A	Silent	p.L44L	1
DRD2	SKCM	chr11	113286191	113286191	G	A	Silent	p.T225T	1
DRD2	BLCA	chr11	113286216	113286216	C	T	Missense_Mutation		1
DRD2	ESCA	chr11	113295305	113295305	G	A	Silent	p.N23	1
DRD2	LUAD	chr11	113286296	113286296	C	A	Silent	p.V190V	1
DRD2	LUAD	chr11	113283323	113283323	G	-	Frame_Shift_Del	p.Q366fs	1
DRD2	BLCA	chr11	113283349	113283349	T	C	Missense_Mutation	p.K356R	1
DRD2	HNSC	chr11	113295162	113295162	T	A	Missense_Mutation		1
DRD2	PAAD	chr11	113281640	113281640	C	T	Missense_Mutation		1
DRD2	SKCM	chr11	113286293	113286293	G	A	Silent	p.V191V	1
DRD2	THYM	chr11	113287666	113287666	G	T	Silent	p.R151R	1
DRD2	COAD	chr11	113283526	113283526	G	T	Missense_Mutation	p.P297H	1
DRD2	KIRC	chr11	113295088	113295088	C	T	Splice_Site	.	1
DRD2	SKCM	chr11	113283497	113283497	G	A	Missense_Mutation	p.L307F	1
DRD2	BLCA	chr11	113295338	113295338	A	C	Missense_Mutation		1
DRD2	SARC	chr11	113283521	113283521	G	A	Missense_Mutation	p.P299S	1
DRD2	LUAD	chr11	113295193	113295193	G	-	Frame_Shift_Del	p.R61fs	1
DRD2	STAD	chr11	113286314	113286314	A	G	Silent	p.I184I	1
DRD2	BLCA	chr11	113295282	113295282	C	G	Missense_Mutation	p.R31T	1
DRD2	HNSC	chr11	113295255	113295255	A	T	Missense_Mutation		1
DRD2	LUAD	chr11	113283328	113283328	A	T	Missense_Mutation	p.L363H	1
DRD2	SKCM	chr11	113283471	113283471	G	A	Silent	p.L315L	1
DRD2	UCEC	chr11	113287604	113287604	G	C	Silent	p.L171L	1
DRD2	KIRC	chr11	113295088	113295088	C	T	Missense_Mutation	p.V96I	1
DRD2	SKCM	chr11	113295346	113295346	C	T	Missense_Mutation	p.D10N	1
DRD2	BLCA	chr11	113283349	113283349	T	C	Missense_Mutation		1
DRD2	ESCA	chr11	113286268	113286268	C	T	Missense_Mutation		1
DRD2	SARC	chr11	113295128	113295128	G	A	Silent	p.L82L	1
DRD2	LUAD	chr11	113287585	113287585	C	A	Missense_Mutation	p.D178Y	1
DRD2	STAD	chr11	113295190	113295190	C	T	Missense_Mutation	p.E62K	1
DRD2	BLCA	chr11	113295146	113295146	G	A	Silent	p.L76L	1
DRD2	HNSC	chr11	113281596	113281596	C	T	Silent		1
DRD2	SKCM	chr11	113283376	113283376	G	A	Missense_Mutation	p.P347L	1
DRD2	UCEC	chr11	113286299	113286299	G	A	Silent	p.F189F	1
DRD2	COAD	chr11	113295179	113295179	C	T	Silent	p.L65L	1
DRD2	BLCA	chr11	113295282	113295282	C	G	Missense_Mutation		1
DRD2	ESCA	chr11	113285184	113285184	C	A	Splice_Site		1
DRD2	SARC	chr11	113283521	113283521	G	A	Missense_Mutation	p.P301S	1
DRD2	LIHC	chr11	113295219	113295219	T	A	Missense_Mutation	p.N52I	1
DRD2	LUAD	chr11	113285167	113285168	GG	TT	Missense_Mutation	p.P247N	1
DRD2	STAD	chr11	113283413	113283413	G	T	Missense_Mutation	p.P335T	1
DRD2	HNSC	chr11	113283503	113283503	G	A	Silent		1
DRD2	SKCM	chr11	113281573	113281573	A	G	Missense_Mutation	p.I403T	1
DRD2	COAD	chr11	113295224	113295224	G	A	Silent	p.F50F	1
DRD2	KIRP	chr11	113295145	113295145	C	T	Missense_Mutation	p.A77T	1
DRD2	BLCA	chr11	113295146	113295146	G	A	Silent		1
DRD2	ESCA	chr11	113295289	113295289	C	T	Missense_Mutation		1
DRD2	SARC	chr11	113295128	113295128	G	A	Silent	p.L82	1
DRD2	LIHC	chr11	113281524	113281524	G	T	Missense_Mutation	p.S419R	1
DRD2	LUSC	chr11	113283559	113283559	C	T	Missense_Mutation	p.S286N	1
DRD2	SKCM	chr11	113281476	113281476	C	T	Silent	p.K435K	1
DRD2	STAD	chr11	113295140	113295140	C	T	Silent	p.V78V	1
DRD2	BLCA	chr11	113283435	113283435	C	T	Silent	p.K327K	1
DRD2	HNSC	chr11	113288779	113288779	A	T	Missense_Mutation		1
DRD2	UCS	chr11	113285165	113285165	C	T	Missense_Mutation		1
DRD2	LUAD	chr11	113288749	113288749	C	G	Splice_Site	p.R132_splice	1
DRD2	SKCM	chr11	113287661	113287661	G	A	Silent	p.V152V	1
DRD2	LUAD	chr11	113281624	113281624	C	A	Missense_Mutation	p.W386L	1
DRD2	LUAD	chr11	113287585	113287585	C	A	Splice_Site	p.D178_splice	1
DRD2	LUSC	chr11	113283341	113283341	T	C	Missense_Mutation	p.S359G	1
DRD2	SKCM	chr11	113283545	113283545	C	T	Missense_Mutation	p.E291K	1
DRD2	THCA	chr11	113283484	113283484	G	C	Missense_Mutation		1
DRD2	HNSC	chr11	113288779	113288779	A	T	Missense_Mutation	p.I122N	1
DRD2	LUAD	chr11	113283509	113283509	G	T	Missense_Mutation	p.H303N	1
DRD2	SKCM	chr11	113283550	113283550	G	A	Missense_Mutation	p.P289L	1
DRD2	COAD	chr11	113288764	113288764	G	A	Missense_Mutation	p.A127V	1
DRD2	KIRP	chr11	113288847	113288847	C	T	Silent		1
DRD2	BLCA	chr11	113286260	113286260	G	A	Silent		1
DRD2	ESCA	chr11	113285184	113285184	C	A	Splice_Site	.	1
DRD2	LUSC	chr11	113283468	113283468	G	T	Missense_Mutation	p.H316Q	1
DRD2	SKCM	chr11	113287689	113287689	T	G	Missense_Mutation	p.N143T	1
DRD2	THYM	chr11	113283559	113283559	C	T	Missense_Mutation		1
DRD2	HNSC	chr11	113295255	113295255	A	T	Missense_Mutation	p.L40Q	1
DRD2	COAD	chr11	113295183	113295183	G	A	Missense_Mutation	p.A64V	1
DRD2	KIRP	chr11	113295344	113295344	A	G	Silent		1
DRD2	LUAD	chr11	113287652	113287652	C	A	Missense_Mutation	p.M155I	1
DRD2	SKCM	chr11	113286168	113286168	C	T	Missense_Mutation	p.R233K	1
DRD2	BLCA	chr11	113285126	113285126	C	A	Missense_Mutation		1
DRD2	GBM	chr11	113286210	113286210	C	T	Missense_Mutation	p.R219H	1
DRD2	LUAD	chr11	113285144	113285144	C	A	Missense_Mutation	p.V255F	1
DRD2	LUSC	chr11	113281606	113281606	G	T	Missense_Mutation	p.T392K	1
DRD2	SKCM	chr11	113295435	113295435	G	T	Translation_Start_Site		1
DRD2	THYM	chr11	113287666	113287666	G	T	Silent		1
DRD2	ESCA	chr11	113283425	113283425	C	G	Missense_Mutation	p.A333P	1
DRD2	LUAD	chr11	113286306	113286306	G	T	Missense_Mutation	p.P187Q	1
DRD2	READ	chr11	113281523	113281523	C	T	Missense_Mutation	p.A391T	1
DRD2	SKCM	chr11	113286220	113286220	G	A	Missense_Mutation	p.L216F	1
DRD2	BLCA	chr11	113283435	113283435	C	T	Silent		1
DRD2	GBM	chr11	113285181	113285181	G	A	Silent		1
DRD2	LUAD	chr11	113281583	113281583	C	A	Missense_Mutation	p.D400Y	1

Copy number variation (CNV) of DRD2
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across DRD2
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
97306	N/A	BE835045	DRD2	chr11	113282109	+	DRD2	chr11	113281573	-
97310	SKCM	TCGA-GN-A26D-06A	USP28	chr11	113712385	-	DRD2	chr11	113295404	-
97310	SKCM	TCGA-GN-A26D-06A	USP28	chr11	113712385	-	DRD2	chr11	113371471	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type

Translation factor

pval

adj.p

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type

Translation factor

pval

adj.p

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
P14416	DB00182	Amphetamine	Binder	Small molecule	Approved\|Illicit\|Investigational
P14416	DB00268	Ropinirole	Agonist	Small molecule	Approved\|Investigational
P14416	DB00372	Thiethylperazine	Antagonist	Small molecule	Approved\|Withdrawn
P14416	DB00420	Promazine	Antagonist	Small molecule	Approved\|Vet_approved
P14416	DB00433	Prochlorperazine	Antagonist	Small molecule	Approved\|Vet_approved
P14416	DB00450	Droperidol	Antagonist	Small molecule	Approved\|Vet_approved
P14416	DB00458	Imipramine	Binder	Small molecule	Approved
P14416	DB00508	Triflupromazine	Antagonist	Small molecule	Approved\|Vet_approved
P14416	DB00540	Nortriptyline	Antagonist	Small molecule	Approved
P14416	DB00555	Lamotrigine	Agonist\|Inhibitor	Small molecule	Approved\|Investigational
P14416	DB00568	Cinnarizine	Other/unknown	Small molecule	Approved\|Investigational
P14416	DB00623	Fluphenazine	Antagonist	Small molecule	Approved
P14416	DB00679	Thioridazine	Antagonist	Small molecule	Approved\|Withdrawn
P14416	DB00696	Ergotamine	Agonist	Small molecule	Approved
P14416	DB00715	Paroxetine	Other/unknown	Small molecule	Approved\|Investigational
P14416	DB00726	Trimipramine	Other/unknown	Small molecule	Approved
P14416	DB00734	Risperidone	Antagonist	Small molecule	Approved\|Investigational
P14416	DB00777	Propiomazine	Antagonist	Small molecule	Approved
P14416	DB00805	Minaprine	Agonist	Small molecule	Approved
P14416	DB00831	Trifluoperazine	Antagonist	Small molecule	Approved\|Investigational
P14416	DB00850	Perphenazine	Antagonist	Small molecule	Approved
P14416	DB00875	Flupentixol	Antagonist	Small molecule	Approved\|Investigational\|Withdrawn
P14416	DB00915	Amantadine	Agonist	Small molecule	Approved
P14416	DB00933	Mesoridazine	Antagonist	Small molecule	Approved\|Investigational
P14416	DB00934	Maprotiline	Binder	Small molecule	Approved\|Investigational
P14416	DB01038	Carphenazine	Antagonist	Small molecule	Withdrawn
P14416	DB01043	Memantine	Agonist\|Antagonist	Small molecule	Approved\|Investigational
P14416	DB01063	Acetophenazine	Antagonist	Small molecule	Approved
P14416	DB01069	Promethazine	Antagonist	Small molecule	Approved\|Investigational
P14416	DB01151	Desipramine	Binder	Small molecule	Approved\|Investigational
P14416	DB01175	Escitalopram	Inhibitor	Small molecule	Approved
P14416	DB01221	Ketamine	Agonist\|Partial agonist	Small molecule	Approved\|Vet_approved
P14416	DB01233	Metoclopramide	Antagonist	Small molecule	Approved\|Investigational
P14416	DB01425	Alizapride	Antagonist	Small molecule	Investigational
P14416	DB01549	Rolicyclidine		Small molecule	Experimental\|Illicit
P14416	DB01614	Acepromazine	Antagonist	Small molecule	Experimental\|Vet_approved
P14416	DB01618	Molindone	Antagonist	Small molecule	Approved
P14416	DB01621	Pipotiazine	Antagonist	Small molecule	Approved\|Investigational
P14416	DB01622	Thioproperazine	Antagonist	Small molecule	Experimental
P14416	DB01623	Thiothixene	Antagonist	Small molecule	Approved
P14416	DB01624	Zuclopenthixol	Antagonist	Small molecule	Approved\|Investigational
P14416	DB04599	Aniracetam		Small molecule	Experimental
P14416	DB04842	Fluspirilene	Antagonist	Small molecule	Approved\|Investigational
P14416	DB04844	Tetrabenazine	Inhibitor	Small molecule	Approved\|Investigational
P14416	DB04857	Brasofensine		Small molecule	Investigational
P14416	DB04888	Bifeprunox		Small molecule	Investigational
P14416	DB04889	Bicifadine		Small molecule	Investigational
P14416	DB04924	Itopride		Small molecule	Investigational
P14416	DB05271	Rotigotine	Agonist	Small molecule	Approved
P14416	DB05316	Pimavanserin		Small molecule	Approved\|Investigational
P14416	DB05687	BL-1020		Small molecule	Investigational
P14416	DB05964	Amitifadine		Small molecule	Investigational
P14416	DB06016	Cariprazine	Agonist\|Partial agonist	Small molecule	Approved\|Investigational
P14416	DB06077	Lumateperone	Partial agonist	Small molecule	Approved\|Investigational
P14416	DB06109	YKP-1358	Antagonist	Small molecule	Investigational
P14416	DB06144	Sertindole	Antagonist	Small molecule	Approved\|Investigational\|Withdrawn
P14416	DB06148	Mianserin	Antagonist	Small molecule	Approved\|Investigational
P14416	DB06229	Ocaperidone		Small molecule	Investigational
P14416	DB08815	Lurasidone	Antagonist	Small molecule	Approved\|Investigational
P14416	DB09018	Bromopride	Antagonist	Small molecule	Investigational
P14416	DB09097	Quinagolide	Agonist	Small molecule	Approved\|Investigational
P14416	DB09128	Brexpiprazole	Agonist\|Partial agonist	Small molecule	Approved\|Investigational
P14416	DB09194	Etoperidone	Antagonist	Small molecule	Withdrawn
P14416	DB09224	Melperone	Antagonist	Small molecule	Investigational
P14416	DB09225	Zotepine	Antagonist	Small molecule	Approved\|Investigational\|Withdrawn
P14416	DB12093	Tetrahydropalmatine	Antagonist	Small molecule	Investigational
P14416	DB12518	Raclopride	Antagonist	Small molecule	Investigational
P14416	DB12579	JNJ-37822681	Antagonist	Small molecule	Investigational
P14416	DB00182	Amphetamine	Binder
P14416	DB00268	Ropinirole	Agonist
P14416	DB00372	Thiethylperazine	Antagonist
P14416	DB00420	Promazine	Antagonist
P14416	DB00433	Prochlorperazine	Antagonist
P14416	DB00450	Droperidol	Antagonist
P14416	DB00458	Imipramine	Binder
P14416	DB00508	Triflupromazine	Antagonist
P14416	DB00540	Nortriptyline	Antagonist
P14416	DB00555	Lamotrigine	Agonist\|Inhibitor
P14416	DB00568	Cinnarizine	Other/unknown
P14416	DB00623	Fluphenazine	Antagonist
P14416	DB00679	Thioridazine	Antagonist
P14416	DB00696	Ergotamine	Agonist
P14416	DB00715	Paroxetine	Other/unknown
P14416	DB00726	Trimipramine	Other/unknown
P14416	DB00734	Risperidone	Antagonist
P14416	DB00777	Propiomazine	Antagonist
P14416	DB00805	Minaprine	Agonist
P14416	DB00831	Trifluoperazine	Antagonist
P14416	DB00850	Perphenazine	Antagonist
P14416	DB00875	Flupentixol	Antagonist
P14416	DB00915	Amantadine	Agonist
P14416	DB00933	Mesoridazine	Antagonist
P14416	DB00934	Maprotiline	Binder
P14416	DB01038	Carphenazine	Antagonist
P14416	DB01043	Memantine	Agonist\|Antagonist
P14416	DB01063	Acetophenazine	Antagonist
P14416	DB01069	Promethazine	Antagonist
P14416	DB01151	Desipramine	Binder
P14416	DB01175	Escitalopram	Inhibitor
P14416	DB01221	Ketamine	Agonist\|Partial agonist
P14416	DB01233	Metoclopramide	Antagonist
P14416	DB01425	Alizapride	Antagonist
P14416	DB01549	Rolicyclidine
P14416	DB01614	Acepromazine	Antagonist
P14416	DB01618	Molindone	Antagonist
P14416	DB01621	Pipotiazine	Antagonist
P14416	DB01622	Thioproperazine	Antagonist
P14416	DB01623	Thiothixene	Antagonist
P14416	DB01624	Zuclopenthixol	Antagonist
P14416	DB04599	Aniracetam
P14416	DB04842	Fluspirilene	Antagonist
P14416	DB04844	Tetrabenazine	Inhibitor
P14416	DB04857	Brasofensine
P14416	DB04888	Bifeprunox
P14416	DB04889	Bicifadine
P14416	DB04924	Itopride
P14416	DB05271	Rotigotine	Agonist
P14416	DB05316	Pimavanserin
P14416	DB05687	BL-1020
P14416	DB05964	Amitifadine
P14416	DB06016	Cariprazine	Agonist\|Partial agonist
P14416	DB06077	Lumateperone	Partial agonist
P14416	DB06109	YKP-1358	Antagonist
P14416	DB06144	Sertindole	Antagonist
P14416	DB06148	Mianserin	Antagonist
P14416	DB06229	Ocaperidone
P14416	DB08815	Lurasidone	Antagonist
P14416	DB09018	Bromopride	Antagonist
P14416	DB09097	Quinagolide	Agonist
P14416	DB09128	Brexpiprazole	Agonist\|Partial agonist
P14416	DB09194	Etoperidone	Antagonist
P14416	DB09224	Melperone	Antagonist
P14416	DB09225	Zotepine	Antagonist
P14416	DB12093	Tetrahydropalmatine	Antagonist
P14416	DB12518	Raclopride	Antagonist
P14416	DB12579	JNJ-37822681	Antagonist

Top

Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0600427	Cocaine Dependence	15	CTD_human;PSYGENET
C0009171	Cocaine Abuse	14	CTD_human;PSYGENET
C0001973	Alcoholic Intoxication, Chronic	5	PSYGENET
C0005586	Bipolar Disorder	5	PSYGENET
C0011570	Mental Depression	5	PSYGENET
C0011581	Depressive disorder	5	PSYGENET
C0041696	Unipolar Depression	5	PSYGENET
C0085762	Alcohol abuse	5	PSYGENET
C0750951	Lenticulostriate Disorders	5	CTD_human
C1269683	Major Depressive Disorder	5	PSYGENET
C0007370	Catalepsy	4	CTD_human
C0036341	Schizophrenia	4	CTD_human
C0013386	Dyskinesia, Drug-Induced	3	CTD_human
C0021776	Intermittent Explosive Disorder	3	CTD_human
C0022333	Jacksonian Seizure	3	CTD_human
C0149958	Complex partial seizures	3	CTD_human
C0234533	Generalized seizures	3	CTD_human
C0234535	Clonic Seizures	3	CTD_human
C0236804	Amphetamine Addiction	3	CTD_human
C0236807	Amphetamine Abuse	3	CTD_human
C0242423	Ramsay Hunt Paralysis Syndrome	3	CTD_human
C0270824	Visual seizure	3	CTD_human
C0270846	Epileptic drop attack	3	CTD_human
C0494475	Tonic - clonic seizures	3	CTD_human
C0751110	Single Seizure	3	CTD_human
C0752097	Autosomal Dominant Juvenile Parkinson Disease	3	CTD_human
C0752098	Autosomal Dominant Parkinsonism	3	CTD_human
C0752100	Autosomal Recessive Parkinsonism	3	CTD_human
C0752101	Parkinsonism, Experimental	3	CTD_human
C0752104	Familial Juvenile Parkinsonism	3	CTD_human
C0752105	Parkinsonism, Juvenile	3	CTD_human
C1868675	PARKINSON DISEASE 2, AUTOSOMAL RECESSIVE JUVENILE	3	CTD_human
C0006870	Cannabis Dependence	2	PSYGENET
C0011206	Delirium	2	PSYGENET
C0020514	Hyperprolactinemia	2	CTD_human
C0024809	Marijuana Abuse	2	PSYGENET
C0376280	Anxiety States, Neurotic	2	CTD_human
C1279420	Anxiety neurosis (finding)	2	CTD_human
C0013384	Dyskinetic syndrome	1	CTD_human
C0019337	Heroin Dependence	1	CTD_human
C0024517	Major depression, single episode	1	PSYGENET
C0025261	Memory Disorders	1	CTD_human
C0028043	Nicotine Dependence	1	CTD_human
C0029231	Organic Mental Disorders, Substance-Induced	1	CTD_human
C0030567	Parkinson Disease	1	CTD_human
C0032000	Pituitary Adenoma	1	CTD_human
C0038580	Substance Dependence	1	CTD_human
C0038587	Substance Withdrawal Syndrome	1	CTD_human
C0040332	Tobacco Dependence	1	CTD_human
C0041671	Attention Deficit Disorder	1	CTD_human
C0085996	Child Development Deviations	1	CTD_human
C0085997	Child Development Disorders, Specific	1	CTD_human
C0152115	Lingual-Facial-Buccal Dyskinesia	1	CTD_human
C0178417	Anhedonia	1	PSYGENET
C0221169	Hemiballismus	1	CTD_human
C0221480	Recurrent depression	1	PSYGENET
C0266487	Etat Marbre	1	CTD_human
C0346300	Pituitary carcinoma	1	CTD_human
C0454606	Oral Dyskinesia	1	CTD_human
C0600241	heroin abuse	1	CTD_human
C0740858	Substance abuse problem	1	CTD_human
C0752196	Ballismus	1	CTD_human
C1263846	Attention deficit hyperactivity disorder	1	CTD_human
C1321905	Minimal Brain Dysfunction	1	CTD_human
C4505390	Heroin Smoking	1	CTD_human