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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: EIF5 (NCBI Gene ID:1983)

Gene Summary

Gene Summary

Gene Information	Gene Name: EIF5
	Gene ID: 1983
	Gene Symbol	EIF5
	Gene ID	1983
	Gene Name	eukaryotic translation initiation factor 5
	Synonyms	EIF-5\|EIF-5A
	Cytomap	14q32.32
	Type of Gene	protein-coding
	Description	eukaryotic translation initiation factor 5
	Modification date	20200313
	UniProtAcc	P55010

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0008135	Translation factor activity, RNA binding
GO:0002181	Cytoplasmic translation
GO:0006413	Translational initiation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	EIF5	GO:0006446	regulation of translational initiation	22156057

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
EIF5	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'EIF5[title] AND translation [title] AND human.'

Gene	Title	PMID
EIF5	Competition between translation initiation factor eIF5 and its mimic protein 5MP determines non-AUG initiation rate genome-wide	28981728

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000216554	103800725	103800934	5UTR-5UTR
ENST00000216554	103802372	103802454	Frame-shift
ENST00000392715	103802372	103802454	Frame-shift
ENST00000558506	103802372	103802454	Frame-shift
ENST00000216554	103803452	103803564	Frame-shift
ENST00000392715	103803452	103803564	Frame-shift
ENST00000558506	103803452	103803564	Frame-shift
ENST00000216554	103805975	103806140	In-frame
ENST00000392715	103805975	103806140	In-frame
ENST00000558506	103805975	103806140	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000392715	103805975	103806140	3434	1440	1604	431	302	357
ENST00000558506	103805975	103806140	4401	1819	1983	431	302	357
ENST00000216554	103805975	103806140	5962	1583	1747	431	302	357

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
P55010	302	357	1	431	Chain	ID=PRO_0000212516;Note=Eukaryotic translation initiation factor 5
P55010	302	357	1	431	Chain	ID=PRO_0000212516;Note=Eukaryotic translation initiation factor 5
P55010	302	357	1	431	Chain	ID=PRO_0000212516;Note=Eukaryotic translation initiation factor 5
P55010	302	357	233	392	Domain	Note=W2;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00695
P55010	302	357	233	392	Domain	Note=W2;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00695
P55010	302	357	233	392	Domain	Note=W2;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00695
P55010	302	357	311	311	Sequence conflict	Note=Q->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
P55010	302	357	311	311	Sequence conflict	Note=Q->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
P55010	302	357	311	311	Sequence conflict	Note=Q->K;Ontology_term=ECO:0000305;evidence=ECO:0000305
P55010	302	357	297	304	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2IU1
P55010	302	357	297	304	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2IU1
P55010	302	357	297	304	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2IU1
P55010	302	357	308	324	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2IU1
P55010	302	357	308	324	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2IU1
P55010	302	357	308	324	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2IU1
P55010	302	357	326	329	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2IU1
P55010	302	357	326	329	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2IU1
P55010	302	357	326	329	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2IU1
P55010	302	357	330	332	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2IU1
P55010	302	357	330	332	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2IU1
P55010	302	357	330	332	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2IU1
P55010	302	357	333	342	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2IU1
P55010	302	357	333	342	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2IU1
P55010	302	357	333	342	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2IU1
P55010	302	357	348	356	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2IU1
P55010	302	357	348	356	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2IU1
P55010	302	357	348	356	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2IU1

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
BRCA	EIF5	-1.16704316213885	0.00107943958337404
LIHC	EIF5	-2.12060405382854	4.66164898670786e-08

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
STAD	EIF5	0.120215268	0.004378282
LGG	EIF5	0.095763496	0.045368131

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with EIF5 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	Cell metabolism gene	EIF5	MTHFD1	0.805973401	2.40E-11
CHOL	Cell metabolism gene	EIF5	ADI1	0.806156651	2.35E-11
CHOL	Cell metabolism gene	EIF5	RDH11	0.806987528	2.16E-11
CHOL	Cell metabolism gene	EIF5	MUT	0.812026023	1.29E-11
CHOL	Cell metabolism gene	EIF5	ALDH6A1	0.816644222	7.96E-12
CHOL	Cell metabolism gene	EIF5	NDST3	0.825401864	3.05E-12
CHOL	IUPHAR	EIF5	KCNN2	0.808995166	1.77E-11
CHOL	IUPHAR	EIF5	SLC16A2	0.844416277	3.13E-13
THYM	TF	EIF5	ZNF304	0.812601996	6.51E-30
UCS	TF	EIF5	ZNF304	0.812601996	6.51E-30
UVM	Cell metabolism gene	EIF5	PMPCB	0.801136327	4.55E-19
UVM	Cell metabolism gene	EIF5	GPAM	0.801930654	3.95E-19
UVM	Cell metabolism gene	EIF5	PHAX	0.802145737	3.81E-19
UVM	Cell metabolism gene	EIF5	NUDT12	0.803135689	3.19E-19
UVM	Cell metabolism gene	EIF5	CLOCK	0.803313937	3.09E-19
UVM	Cell metabolism gene	EIF5	NUP54	0.804612551	2.45E-19
UVM	Cell metabolism gene	EIF5	DCK	0.807486023	1.46E-19
UVM	Cell metabolism gene	EIF5	UGGT2	0.807948815	1.34E-19
UVM	Cell metabolism gene	EIF5	MTR	0.809781578	9.59E-20
UVM	Cell metabolism gene	EIF5	MINPP1	0.812450866	5.83E-20
UVM	Cell metabolism gene	EIF5	PPP1CB	0.813095987	5.17E-20
UVM	Cell metabolism gene	EIF5	MAN1A2	0.815333441	3.38E-20
UVM	Cell metabolism gene	EIF5	SUCLA2	0.816538823	2.68E-20
UVM	Cell metabolism gene	EIF5	TRMT11	0.81685251	2.53E-20
UVM	Cell metabolism gene	EIF5	DIS3	0.816883582	2.51E-20
UVM	Cell metabolism gene	EIF5	AGL	0.819092419	1.64E-20
UVM	Cell metabolism gene	EIF5	AGPS	0.820540556	1.23E-20
UVM	Cell metabolism gene	EIF5	ETNK1	0.821413016	1.04E-20
UVM	Cell metabolism gene	EIF5	MANEA	0.82232318	8.65E-21
UVM	Cell metabolism gene	EIF5	GNAQ	0.82260225	8.18E-21
UVM	Cell metabolism gene	EIF5	PIK3R1	0.823613093	6.68E-21
UVM	Cell metabolism gene	EIF5	EDEM3	0.825635656	4.44E-21
UVM	Cell metabolism gene	EIF5	PIKFYVE	0.826070356	4.06E-21
UVM	Cell metabolism gene	EIF5	POLR3F	0.827091747	3.30E-21
UVM	Cell metabolism gene	EIF5	NAMPT	0.827320443	3.14E-21
UVM	Cell metabolism gene	EIF5	SACM1L	0.828121354	2.67E-21
UVM	Cell metabolism gene	EIF5	DBT	0.829964319	1.82E-21
UVM	Cell metabolism gene	EIF5	FAR1	0.831465426	1.33E-21
UVM	Cell metabolism gene	EIF5	L2HGDH	0.832936942	9.70E-22
UVM	Cell metabolism gene	EIF5	ACADSB	0.83514689	6.03E-22
UVM	Cell metabolism gene	EIF5	NUPL2	0.83590537	5.12E-22
UVM	Cell metabolism gene	EIF5	PSMC6	0.836379157	4.61E-22
UVM	Cell metabolism gene	EIF5	NUPL1	0.840176173	1.99E-22
UVM	Cell metabolism gene	EIF5	MTMR6	0.842053029	1.31E-22
UVM	Cell metabolism gene	EIF5	GXYLT1	0.843286567	9.85E-23
UVM	Cell metabolism gene	EIF5	FBXL3	0.854488953	6.83E-24
UVM	Cell metabolism gene	EIF5	PRKAA1	0.855971131	4.72E-24
UVM	Cell metabolism gene	EIF5	COL4A3BP	0.856164958	4.50E-24
UVM	Cell metabolism gene	EIF5	RANBP2	0.871245618	8.06E-26
UVM	Cell metabolism gene	EIF5	PNPLA8	0.875602291	2.29E-26
UVM	CGC	EIF5	MAP3K1	0.801348255	4.38E-19
UVM	CGC	EIF5	PALB2	0.801495495	4.27E-19
UVM	CGC	EIF5	AFF4	0.803484874	3.00E-19
UVM	CGC	EIF5	CUL3	0.806315666	1.81E-19
UVM	CGC	EIF5	TRIP11	0.810104533	9.03E-20
UVM	CGC	EIF5	GOLGA5	0.810209307	8.86E-20
UVM	CGC	EIF5	ATR	0.812363839	5.93E-20
UVM	CGC	EIF5	HSP90AA1	0.814940884	3.64E-20
UVM	CGC	EIF5	PMS1	0.815404784	3.33E-20
UVM	CGC	EIF5	SBDS	0.815694292	3.15E-20
UVM	CGC	EIF5	CREB1	0.816093256	2.92E-20
UVM	CGC	EIF5	ATF1	0.81794266	2.05E-20
UVM	CGC	EIF5	BCLAF1	0.818650402	1.78E-20
UVM	CGC	EIF5	FBXO11	0.819294093	1.57E-20
UVM	CGC	EIF5	ETNK1	0.821413016	1.04E-20
UVM	CGC	EIF5	GNAQ	0.82260225	8.18E-21
UVM	CGC	EIF5	PIK3R1	0.823613093	6.68E-21
UVM	CGC	EIF5	RAD17	0.826239667	3.92E-21
UVM	CGC	EIF5	USP8	0.82631754	3.86E-21
UVM	CGC	EIF5	ERCC4	0.827547879	3.00E-21
UVM	CGC	EIF5	CDC73	0.828873236	2.28E-21
UVM	CGC	EIF5	GOPC	0.830255446	1.71E-21
UVM	CGC	EIF5	MALT1	0.835055334	6.15E-22
UVM	CGC	EIF5	RB1	0.835061114	6.14E-22
UVM	CGC	EIF5	PHF6	0.836272904	4.72E-22
UVM	CGC	EIF5	KTN1	0.838661704	2.79E-22
UVM	CGC	EIF5	ZMYM2	0.840019733	2.06E-22
UVM	CGC	EIF5	STAG2	0.844142986	8.10E-23
UVM	CGC	EIF5	POT1	0.851089471	1.57E-23
UVM	CGC	EIF5	DDX5	0.851966319	1.27E-23
UVM	CGC	EIF5	ARHGAP5	0.856465158	4.17E-24
UVM	CGC	EIF5	SF3B1	0.858762039	2.33E-24
UVM	CGC	EIF5	RGPD3	0.866179298	3.29E-25
UVM	CGC	EIF5	SUZ12	0.87046096	1.01E-25
UVM	CGC	EIF5	DICER1	0.870597739	9.68E-26
UVM	CGC	EIF5	RANBP2	0.871245618	8.06E-26
UVM	Epifactor	EIF5	EID1	0.80058987	5.01E-19
UVM	Epifactor	EIF5	TAF7	0.801074978	4.60E-19
UVM	Epifactor	EIF5	CLOCK	0.803313937	3.09E-19
UVM	Epifactor	EIF5	HMGB1	0.80382385	2.83E-19
UVM	Epifactor	EIF5	HCFC2	0.805895674	1.95E-19
UVM	Epifactor	EIF5	CUL3	0.806315666	1.81E-19
UVM	Epifactor	EIF5	YY1	0.806509202	1.74E-19
UVM	Epifactor	EIF5	ATAD2B	0.807360932	1.49E-19
UVM	Epifactor	EIF5	ATR	0.812363839	5.93E-20
UVM	Epifactor	EIF5	UCHL5	0.81295398	5.31E-20
UVM	Epifactor	EIF5	JMJD1C	0.813698343	4.61E-20
UVM	Epifactor	EIF5	HAT1	0.815416703	3.33E-20
UVM	Epifactor	EIF5	RMI1	0.817215996	2.35E-20
UVM	Epifactor	EIF5	NSL1	0.817321706	2.31E-20
UVM	Epifactor	EIF5	EPC1	0.818115851	1.98E-20
UVM	Epifactor	EIF5	RCOR3	0.81908605	1.64E-20
UVM	Epifactor	EIF5	BRMS1L	0.819544798	1.50E-20
UVM	Epifactor	EIF5	USP15	0.823705527	6.56E-21
UVM	Epifactor	EIF5	ZRANB3	0.825406785	4.65E-21
UVM	Epifactor	EIF5	MBIP	0.825987546	4.13E-21
UVM	Epifactor	EIF5	MBTD1	0.827573431	2.98E-21
UVM	Epifactor	EIF5	DNTTIP2	0.828101938	2.68E-21
UVM	Epifactor	EIF5	MAP3K7	0.82871287	2.36E-21
UVM	Epifactor	EIF5	CDC73	0.828873236	2.28E-21
UVM	Epifactor	EIF5	BRCC3	0.833691551	8.25E-22
UVM	Epifactor	EIF5	RB1	0.835061114	6.14E-22
UVM	Epifactor	EIF5	CHUK	0.836918208	4.10E-22
UVM	Epifactor	EIF5	YEATS4	0.836987223	4.04E-22
UVM	Epifactor	EIF5	ZMYM2	0.840019733	2.06E-22
UVM	Epifactor	EIF5	PHIP	0.841822806	1.38E-22
UVM	Epifactor	EIF5	ARID4A	0.842876348	1.08E-22
UVM	Epifactor	EIF5	SMEK1	0.845368361	6.10E-23
UVM	Epifactor	EIF5	BAZ2B	0.847838361	3.42E-23
UVM	Epifactor	EIF5	CHD9	0.852702583	1.06E-23
UVM	Epifactor	EIF5	NIPBL	0.853239532	9.30E-24
UVM	Epifactor	EIF5	PRKAA1	0.855971131	4.72E-24
UVM	Epifactor	EIF5	SMEK2	0.856621191	4.01E-24
UVM	Epifactor	EIF5	EPC2	0.858673419	2.38E-24
UVM	Epifactor	EIF5	SF3B1	0.858762039	2.33E-24
UVM	Epifactor	EIF5	ZMYND11	0.861224891	1.23E-24
UVM	Epifactor	EIF5	CUL2	0.869557022	1.30E-25
UVM	Epifactor	EIF5	SUZ12	0.87046096	1.01E-25
UVM	Epifactor	EIF5	TLK1	0.871918854	6.66E-26
UVM	Epifactor	EIF5	CUL5	0.874003944	3.66E-26
UVM	IUPHAR	EIF5	MAP3K1	0.801348255	4.38E-19
UVM	IUPHAR	EIF5	SLK	0.802199075	3.77E-19
UVM	IUPHAR	EIF5	CLK4	0.802261795	3.73E-19
UVM	IUPHAR	EIF5	CLOCK	0.803313937	3.09E-19
UVM	IUPHAR	EIF5	ABCA5	0.803453736	3.02E-19
UVM	IUPHAR	EIF5	ATAD2B	0.807360932	1.49E-19
UVM	IUPHAR	EIF5	SLC25A46	0.809459643	1.02E-19
UVM	IUPHAR	EIF5	MTR	0.809781578	9.59E-20
UVM	IUPHAR	EIF5	ATR	0.812363839	5.93E-20
UVM	IUPHAR	EIF5	TBK1	0.81281509	5.45E-20
UVM	IUPHAR	EIF5	JMJD1C	0.813698343	4.61E-20
UVM	IUPHAR	EIF5	HSP90AA1	0.814940884	3.64E-20
UVM	IUPHAR	EIF5	NR3C1	0.815239775	3.44E-20
UVM	IUPHAR	EIF5	HAT1	0.815416703	3.33E-20
UVM	IUPHAR	EIF5	USP1	0.81578622	3.10E-20
UVM	IUPHAR	EIF5	FBXO11	0.819294093	1.57E-20
UVM	IUPHAR	EIF5	MFN1	0.8201577	1.33E-20
UVM	IUPHAR	EIF5	NEK7	0.821550895	1.01E-20
UVM	IUPHAR	EIF5	GNAQ	0.82260225	8.18E-21
UVM	IUPHAR	EIF5	SENP6	0.823544653	6.77E-21
UVM	IUPHAR	EIF5	PIK3R1	0.823613093	6.68E-21
UVM	IUPHAR	EIF5	HIPK3	0.823829849	6.40E-21
UVM	IUPHAR	EIF5	RIOK3	0.825266199	4.78E-21
UVM	IUPHAR	EIF5	PIKFYVE	0.826070356	4.06E-21
UVM	IUPHAR	EIF5	SCYL2	0.826532344	3.70E-21
UVM	IUPHAR	EIF5	ATP11B	0.828500238	2.46E-21
UVM	IUPHAR	EIF5	MAP3K7	0.82871287	2.36E-21
UVM	IUPHAR	EIF5	NEK1	0.830017769	1.80E-21
UVM	IUPHAR	EIF5	NR2C1	0.830476623	1.63E-21
UVM	IUPHAR	EIF5	IRAK4	0.834507263	6.92E-22
UVM	IUPHAR	EIF5	MALT1	0.835055334	6.15E-22
UVM	IUPHAR	EIF5	CHUK	0.836918208	4.10E-22
UVM	IUPHAR	EIF5	XIAP	0.837235679	3.82E-22
UVM	IUPHAR	EIF5	PHIP	0.841822806	1.38E-22
UVM	IUPHAR	EIF5	BAZ2B	0.847838361	3.42E-23
UVM	IUPHAR	EIF5	CSNK1G3	0.854127484	7.47E-24
UVM	IUPHAR	EIF5	PRKAA1	0.855971131	4.72E-24
UVM	IUPHAR	EIF5	MAP3K2	0.859044324	2.16E-24
UVM	IUPHAR	EIF5	TNKS2	0.860897851	1.34E-24
UVM	IUPHAR	EIF5	ZMYND11	0.861224891	1.23E-24
UVM	IUPHAR	EIF5	TLK1	0.871918854	6.66E-26
UVM	IUPHAR	EIF5	TRPM7	0.874958992	2.77E-26
UVM	Kinase	EIF5	MAP3K1	0.801348255	4.38E-19
UVM	Kinase	EIF5	SLK	0.802199075	3.77E-19
UVM	Kinase	EIF5	CLK4	0.802261795	3.73E-19
UVM	Kinase	EIF5	PAN3	0.808112041	1.30E-19
UVM	Kinase	EIF5	ATR	0.812363839	5.93E-20
UVM	Kinase	EIF5	TBK1	0.81281509	5.45E-20
UVM	Kinase	EIF5	NEK7	0.821550895	1.01E-20
UVM	Kinase	EIF5	HIPK3	0.823829849	6.40E-21
UVM	Kinase	EIF5	RIOK3	0.825266199	4.78E-21
UVM	Kinase	EIF5	SCYL2	0.826532344	3.70E-21
UVM	Kinase	EIF5	MAP3K7	0.82871287	2.36E-21
UVM	Kinase	EIF5	NEK1	0.830017769	1.80E-21
UVM	Kinase	EIF5	IRAK4	0.834507263	6.92E-22
UVM	Kinase	EIF5	CHUK	0.836918208	4.10E-22
UVM	Kinase	EIF5	CSNK1G3	0.854127484	7.47E-24
UVM	Kinase	EIF5	PRKAA1	0.855971131	4.72E-24
UVM	Kinase	EIF5	COL4A3BP	0.856164958	4.50E-24
UVM	Kinase	EIF5	MAP3K2	0.859044324	2.16E-24
UVM	Kinase	EIF5	TLK1	0.871918854	6.66E-26
UVM	Kinase	EIF5	TRPM7	0.874958992	2.77E-26
UVM	TF	EIF5	ZNF799	0.800454239	5.13E-19
UVM	TF	EIF5	MYNN	0.801335635	4.39E-19
UVM	TF	EIF5	ZNF354B	0.802068113	3.86E-19
UVM	TF	EIF5	ZNF527	0.803204991	3.16E-19
UVM	TF	EIF5	CLOCK	0.803313937	3.09E-19
UVM	TF	EIF5	ZNF45	0.803334918	3.08E-19
UVM	TF	EIF5	LIN54	0.803400092	3.05E-19
UVM	TF	EIF5	CEBPZ	0.803566591	2.96E-19
UVM	TF	EIF5	ZBTB25	0.804934295	2.32E-19
UVM	TF	EIF5	ZNF420	0.805325241	2.16E-19
UVM	TF	EIF5	ZNF248	0.80552873	2.08E-19
UVM	TF	EIF5	ZNF625	0.805553228	2.07E-19
UVM	TF	EIF5	ZNF655	0.805979206	1.92E-19
UVM	TF	EIF5	ZNF557	0.8064424	1.77E-19
UVM	TF	EIF5	ZNF20	0.806471709	1.76E-19
UVM	TF	EIF5	YY1	0.806509202	1.74E-19
UVM	TF	EIF5	ZNF761	0.806759927	1.67E-19
UVM	TF	EIF5	ZFP1	0.807538879	1.45E-19
UVM	TF	EIF5	THAP1	0.807816703	1.37E-19
UVM	TF	EIF5	ZNF570	0.808247769	1.27E-19
UVM	TF	EIF5	ZNF17	0.808923315	1.12E-19
UVM	TF	EIF5	ZNF253	0.809756644	9.63E-20
UVM	TF	EIF5	ZNF564	0.810300982	8.71E-20
UVM	TF	EIF5	VEZF1	0.811937275	6.42E-20
UVM	TF	EIF5	ZNF143	0.81236719	5.92E-20
UVM	TF	EIF5	ZNF585B	0.812597533	5.67E-20
UVM	TF	EIF5	ZNF280D	0.812895452	5.36E-20
UVM	TF	EIF5	NFXL1	0.813194665	5.07E-20
UVM	TF	EIF5	MEF2A	0.813685538	4.62E-20
UVM	TF	EIF5	ZNF10	0.81455474	3.92E-20
UVM	TF	EIF5	ZNF292	0.815162029	3.49E-20
UVM	TF	EIF5	NR3C1	0.815239775	3.44E-20
UVM	TF	EIF5	CREB1	0.816093256	2.92E-20
UVM	TF	EIF5	ATF1	0.81794266	2.05E-20
UVM	TF	EIF5	ZNF26	0.818506586	1.83E-20
UVM	TF	EIF5	ZNF235	0.818567534	1.81E-20
UVM	TF	EIF5	ELF2	0.818820831	1.72E-20
UVM	TF	EIF5	ZNF347	0.818966323	1.68E-20
UVM	TF	EIF5	ZNF644	0.819213467	1.60E-20
UVM	TF	EIF5	ZNF431	0.819797843	1.42E-20
UVM	TF	EIF5	ZNF782	0.819908152	1.39E-20
UVM	TF	EIF5	ZNF430	0.820843012	1.16E-20
UVM	TF	EIF5	ZNF37A	0.821098801	1.10E-20
UVM	TF	EIF5	ZNF148	0.821143583	1.09E-20
UVM	TF	EIF5	PURB	0.821724202	9.74E-21
UVM	TF	EIF5	ZNF131	0.822301457	8.68E-21
UVM	TF	EIF5	ZNF627	0.823144963	7.34E-21
UVM	TF	EIF5	ZNF44	0.823711424	6.55E-21
UVM	TF	EIF5	ZNF780B	0.825288314	4.76E-21
UVM	TF	EIF5	ZNF701	0.825316249	4.74E-21
UVM	TF	EIF5	ZNF234	0.825673236	4.40E-21
UVM	TF	EIF5	ZNF268	0.825753491	4.33E-21
UVM	TF	EIF5	ZFP14	0.825859616	4.24E-21
UVM	TF	EIF5	ZNF41	0.826814231	3.49E-21
UVM	TF	EIF5	DMTF1	0.826978018	3.37E-21
UVM	TF	EIF5	AHCTF1	0.827657361	2.93E-21
UVM	TF	EIF5	IKZF5	0.828059228	2.70E-21
UVM	TF	EIF5	ZBED5	0.828780127	2.33E-21
UVM	TF	EIF5	ZNF567	0.82900506	2.22E-21
UVM	TF	EIF5	ZNF28	0.830035126	1.79E-21
UVM	TF	EIF5	NR2C1	0.830476623	1.63E-21
UVM	TF	EIF5	ZNF432	0.831104718	1.43E-21
UVM	TF	EIF5	SP4	0.831301814	1.37E-21
UVM	TF	EIF5	THAP9	0.831751924	1.25E-21
UVM	TF	EIF5	ZNF440	0.834395344	7.09E-22
UVM	TF	EIF5	ZNF674	0.834595516	6.79E-22
UVM	TF	EIF5	ZNF780A	0.834845593	6.44E-22
UVM	TF	EIF5	ZNF658	0.835109429	6.08E-22
UVM	TF	EIF5	RBAK	0.835511339	5.57E-22
UVM	TF	EIF5	THAP6	0.83602544	4.98E-22
UVM	TF	EIF5	ZNF23	0.836984839	4.04E-22
UVM	TF	EIF5	TMF1	0.8377036	3.45E-22
UVM	TF	EIF5	THAP5	0.837814329	3.37E-22
UVM	TF	EIF5	ZNF441	0.838110283	3.15E-22
UVM	TF	EIF5	ZNF383	0.838449975	2.93E-22
UVM	TF	EIF5	ZNF611	0.839957764	2.09E-22
UVM	TF	EIF5	ZNF160	0.840938669	1.68E-22
UVM	TF	EIF5	ZNF181	0.843786807	8.79E-23
UVM	TF	EIF5	ZNF845	0.845482572	5.94E-23
UVM	TF	EIF5	ZBTB11	0.845787624	5.53E-23
UVM	TF	EIF5	ZNF25	0.846407468	4.79E-23
UVM	TF	EIF5	BAZ2B	0.847838361	3.42E-23
UVM	TF	EIF5	SMAD5	0.848301216	3.06E-23
UVM	TF	EIF5	ZNF800	0.850424248	1.84E-23
UVM	TF	EIF5	ZNF700	0.852274874	1.18E-23
UVM	TF	EIF5	ZNF12	0.853550712	8.61E-24
UVM	TF	EIF5	ZNF555	0.853814975	8.07E-24
UVM	TF	EIF5	ZBTB1	0.855620397	5.15E-24
UVM	TF	EIF5	ZNF791	0.855742643	5.00E-24
UVM	TF	EIF5	ZNF558	0.855989198	4.70E-24
UVM	TF	EIF5	ZNF484	0.859086696	2.14E-24
UVM	TF	EIF5	ZNF510	0.861825473	1.05E-24
UVM	TF	EIF5	ZNF14	0.863034184	7.64E-25
UVM	TF	EIF5	ZNF180	0.864353105	5.38E-25
UVM	TF	EIF5	ZNF195	0.86656167	2.96E-25
UVM	TF	EIF5	ZNF136	0.871249439	8.05E-26
UVM	TF	EIF5	SP3	0.877335932	1.37E-26
UVM	TF	EIF5	GPBP1	0.878843886	8.73E-27
UVM	TSG	EIF5	PALB2	0.801495495	4.27E-19
UVM	TSG	EIF5	ANXA7	0.801508505	4.26E-19
UVM	TSG	EIF5	WDR11	0.803396754	3.05E-19
UVM	TSG	EIF5	APAF1	0.806389837	1.78E-19
UVM	TSG	EIF5	ATR	0.812363839	5.93E-20
UVM	TSG	EIF5	ZNF292	0.815162029	3.49E-20
UVM	TSG	EIF5	VEZT	0.818350236	1.89E-20
UVM	TSG	EIF5	USP33	0.818930579	1.69E-20
UVM	TSG	EIF5	FAM188A	0.820412791	1.26E-20
UVM	TSG	EIF5	DMTF1	0.826978018	3.37E-21
UVM	TSG	EIF5	GGNBP2	0.828582529	2.42E-21
UVM	TSG	EIF5	CDC73	0.828873236	2.28E-21
UVM	TSG	EIF5	COPS2	0.829862614	1.86E-21
UVM	TSG	EIF5	EXTL2	0.830447072	1.64E-21
UVM	TSG	EIF5	RB1	0.835061114	6.14E-22
UVM	TSG	EIF5	PHF6	0.836272904	4.72E-22
UVM	TSG	EIF5	CHUK	0.836918208	4.10E-22
UVM	TSG	EIF5	RBBP8	0.838169333	3.11E-22
UVM	TSG	EIF5	NEDD4	0.841527184	1.47E-22
UVM	TSG	EIF5	INTS6	0.844862236	6.86E-23
UVM	TSG	EIF5	MLH3	0.851352337	1.47E-23
UVM	TSG	EIF5	PRKAA1	0.855971131	4.72E-24
UVM	TSG	EIF5	ZMYND11	0.861224891	1.23E-24
UVM	TSG	EIF5	DCLRE1A	0.862657952	8.44E-25
UVM	TSG	EIF5	GORAB	0.862935337	7.84E-25
UVM	TSG	EIF5	CUL2	0.869557022	1.30E-25
UVM	TSG	EIF5	TANK	0.869812506	1.21E-25
UVM	TSG	EIF5	SUZ12	0.87046096	1.01E-25
UVM	TSG	EIF5	DICER1	0.870597739	9.68E-26
UVM	TSG	EIF5	CUL5	0.874003944	3.66E-26
UVM	TSG	EIF5	PPM1A	0.875325925	2.49E-26
UVM	TSG	EIF5	KRIT1	0.893360744	8.00E-29

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KICH	EIF5	EIF3I	1.57310069220802	0.000139892101287842
HNSC	EIF5	EIF1	-4.13399438210909	0.000228392819053625
PRAD	EIF5	EIF3A	1.13680328391952	0.000363360004697762
LIHC	EIF5	EIF3C	-1.23074521883972	0.00126327311470459
LIHC	EIF5	EIF2S3	-4.62530933210412	0.00154404530385922
BRCA	EIF5	EIF3I	-1.72233459275531	0.00191218761269043
KICH	EIF5	EIF2S2	-1.06278646532411	0.00308787822723389
KIRP	EIF5	EIF3G	-2.4178322962129	0.00471024587750435
BLCA	EIF5	EIF3A	-4.45104058307747	0.00532913208007812
KICH	EIF5	EIF4G1	-1.46656081150743	0.00612920522689819
PRAD	EIF5	EIF1	1.32822648991353	0.00674237731133815
UCEC	EIF5	EIF3G	-3.35078334696571	0.03125
BLCA	EIF5	EIF3G	-3.07707559649091	0.0323410034179688
ESCA	EIF5	EIF2S3	-1.31322237574718	0.0419921875
LUAD	EIF5	EIF3B	-5.80435587546762	1.0542655358657e-09
BRCA	EIF5	EIF2S2	-2.57303037687825	1.70212120584918e-09
BRCA	EIF5	EIF3G	1.87948385011271	1.9107949115022e-06
KIRC	EIF5	EIF3B	-1.56313263784517	2.35252849767166e-12
STAD	EIF5	EIF2S2	-2.13186277769467	3.17529775202275e-05
STAD	EIF5	EIF3B	-4.7724660972007	3.25962901115418e-08
HNSC	EIF5	EIF3B	2.6202554263604	4.48234413852334e-06
KIRP	EIF5	EIF3B	-2.7592297042974	4.6566128730774e-09
BRCA	EIF5	EIF3A	-1.218215573148	7.39403582934137e-06

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with EIF5

EIF3G, EIF2S2, DDA1, Nedd4, APP, EIF3B, RPL29, FN1, LMNA, PUM1, NRGN, CAPNS1, DFFA, EIF4H, ALDH7A1, FERMT2, G6PD, GNAI3, PFAS, STK24, VCL, GLA, HNRNPK, HSPA9, ISOC1, MAT2B, PAFAH1B1, PCYT2, PDHB, SCLY, SNRPD1, TBCB, TUBB, UBFD1, YWHAE, YWHAH, YWHAQ, YWHAZ, HUWE1, DUSP12, RPS6, SLC30A4, HSPB1, BZW2, CHD4, CHD5, EIF1, EIF2S1, EIF3I, BZW1, EIF2B2, SRSF2, NTRK1, gag, XPO1, CDH1, CLPB, TXNIP, UBE2M, BPLF1, ATG16L1, GBF1, DCAF15, AGRN, KRAS, APEX1, RHBDD1, RHBDF2, BIRC3, STAU1, TRIM28, LRRK2, PLEKHA4, FYN, ESR1, IMMP1L, IMMP2L, LRRC59, INS, CDC42, NDN, Rnf183, COPS5, DDX58, OGT, ATG7, WDR5, NAA40, NBR1,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
EIF5	chr14	103805501	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
EIF5	PRAD	chr14	103807368	103807368	C	T	Silent	p.D425D	4
EIF5	BRCA	chr14	103803097	103803097	C	T	Missense_Mutation	p.H80Y	4
EIF5	HNSC	chr14	103805991	103805991	A	-	Frame_Shift_Del	p.K309fs	3
EIF5	PAAD	chr14	103805083	103805083	G	T	Missense_Mutation	p.E199D	3
EIF5	UCS	chr14	103803151	103803151	C	A	Missense_Mutation	p.L98I	3
EIF5	ESCA	chr14	103804756	103804757	-	CAC	In_Frame_Ins	p.177_178insH	3
EIF5	BRCA	chr14	103802230	103802230	C	G	Missense_Mutation	p.D11E	3
EIF5	LIHC	chr14	103805615	103805615	T	-	Frame_Shift_Del	p.L284fs	3
EIF5	HNSC	chr14	103807372	103807372	G	C	Missense_Mutation	p.D427H	2
EIF5	PAAD	chr14	103805083	103805083	G	T	Missense_Mutation		2
EIF5	UCEC	chr14	103806788	103806788	G	T	Nonsense_Mutation	p.E366*	2
EIF5	LGG	chr14	103802435	103802435	G	A	Silent		2
EIF5	STAD	chr14	103806054	103806054	C	T	Missense_Mutation	p.L329F	2
EIF5	STAD	chr14	103802238	103802238	A	G	Missense_Mutation	p.Y14C	2
EIF5	STAD	chr14	103803470	103803470	G	A	Silent	p.K115K	2
EIF5	PAAD	chr14	103805668	103805668	C	T	Nonsense_Mutation	p.R302*	2
EIF5	BRCA	chr14	103803551	103803551	C	G	Silent	p.L142	2
EIF5	SKCM	chr14	103803508	103803508	G	A	Missense_Mutation	p.R128Q	2
EIF5	BLCA	chr14	103802407	103802407	T	C	Missense_Mutation	p.I36T	2
EIF5	KICH	chr14	103802243	103802243	T	C	Missense_Mutation	p.Y16H	2
EIF5	STAD	chr14	103807325	103807325	T	C	Missense_Mutation	p.V411A	2
EIF5	SKCM	chr14	103802254	103802254	C	T	Silent	p.P19P	2
EIF5	KIRC	chr14	103802419	103802419	T	C	Missense_Mutation	p.V40A	2
EIF5	SKCM	chr14	103802236	103802236	C	T	Silent	p.F13F	2
EIF5	CESC	chr14	103806896	103806896	G	A	Missense_Mutation		2
EIF5	SKCM	chr14	103805576	103805576	A	G	Missense_Mutation	p.D271G	2
EIF5	LIHC	chr14	103803027	103803027	T	-	Frame_Shift_Del	p.Y56fs	2
EIF5	SKCM	chr14	103805664	103805664	C	T	Silent	p.F300F	2
EIF5	KIRP	chr14	103807312	103807312	A	-	Frame_Shift_Del	p.S406fs	2
EIF5	CESC	chr14	103806896	103806896	G	A	Missense_Mutation	p.E402K	2
EIF5	HNSC	chr14	103802212	103802212	C	G	Silent	p.V5V	2
EIF5	UCEC	chr14	103802255	103802255	C	A	Missense_Mutation	p.R20S	2
EIF5	KIRP	chr14	103807312	103807312	A	-	Frame_Shift_Del	p.K407fs	2
EIF5	UCEC	chr14	103805657	103805657	G	A	Missense_Mutation	p.R298H	2
EIF5	LGG	chr14	103802435	103802435	G	A	Silent	p.A45A	2
EIF5	READ	chr14	103804693	103804693	G	T	Nonsense_Mutation	p.E157X	1
EIF5	COAD	chr14	103804757	103804759	CAC	-	In_Frame_Del	p.178_178del	1
EIF5	LIHC	chr14	103804730	103804730	A	-	Frame_Shift_Del	p.E169fs	1
EIF5	BLCA	chr14	103805628	103805628	G	C	Missense_Mutation		1
EIF5	SKCM	chr14	103804740	103804740	C	T	Silent	p.S172S	1
EIF5	BLCA	chr14	103804671	103804671	T	G	Missense_Mutation	p.S149R	1
EIF5	READ	chr14	103807329	103807329	G	A	Silent	p.P412P	1
EIF5	COAD	chr14	103806901	103806901	A	-	Splice_Site	.	1
EIF5	LIHC	chr14	103805567	103805567	A	-	Frame_Shift_Del	p.E268fs	1
EIF5	BLCA	chr14	103802255	103802255	C	T	Missense_Mutation		1
EIF5	PAAD	chr14	103805668	103805668	C	T	Nonsense_Mutation	p.R302X	1
EIF5	UCS	chr14	103803151	103803151	C	A	Missense_Mutation		1
EIF5	BLCA	chr14	103804685	103804685	G	C	Missense_Mutation	p.G154A	1
EIF5	LGG	chr14	103804767	103804767	A	G	Silent		1
EIF5	COAD	chr14	103806123	103806123	A	G	Missense_Mutation	p.I352V	1
EIF5	LIHC	chr14	103806785	103806785	A	-	Frame_Shift_Del	p.K365fs	1
EIF5	SARC	chr14	103806127	103806127	G	T	Missense_Mutation		1
EIF5	BLCA	chr14	103804671	103804671	T	G	Missense_Mutation		1
EIF5	HNSC	chr14	103805991	103805991	A	-	Frame_Shift_Del	p.K308fs	1
EIF5	BLCA	chr14	103806875	103806875	G	C	Missense_Mutation	p.E395Q	1
EIF5	LIHC	chr14	103806771	103806771	A	G	Missense_Mutation		1
EIF5	ESCA	chr14	103804756	103804757	-	CAC	In_Frame_Ins	p.182in_frame_insP	1
EIF5	LIHC	chr14	103804757	103804759	CAC	-	In_Frame_Del	p.TP178del	1
EIF5	SARC	chr14	103805095	103805095	G	T	Missense_Mutation		1
EIF5	BLCA	chr14	103806875	103806875	G	C	Missense_Mutation		1
EIF5	KICH	chr14	103802243	103802243	T	C	Missense_Mutation		1
EIF5	LIHC	chr14	103803078	103803078	T	C	Silent		1
EIF5	LIHC	chr14	103802378	103802378	G	-	Frame_Shift_Del	p.E26fs	1
EIF5	PAAD	chr14	103805668	103805668	C	T	Nonsense_Mutation		1
EIF5	LIHC	chr14	103805201	103805201	A	G	Missense_Mutation		1
EIF5	HNSC	chr14	103806004	103806004	G	T	Missense_Mutation		1
EIF5	LIHC	chr14	103803552	103803552	A	-	Frame_Shift_Del	p.K143fs	1
EIF5	STAD	chr14	103802217	103802217	G	T	Missense_Mutation	p.R7L	1
EIF5	BLCA	chr14	103804699	103804699	G	C	Missense_Mutation	p.E159Q	1
EIF5	LIHC	chr14	103806063	103806063	A	T	Nonsense_Mutation	p.K332X	1
EIF5	HNSC	chr14	103807372	103807372	G	C	Missense_Mutation		1
EIF5	LUAD	chr14	103805183	103805183	G	A	Missense_Mutation	p.E233K	1
EIF5	STAD	chr14	103803104	103803104	C	T	Missense_Mutation	p.A82V	1
EIF5	BLCA	chr14	103804753	103804753	G	A	Missense_Mutation	p.E177K	1
EIF5	KIRC	chr14	103805089	103805089	T	C	Silent	p.D201D	1
EIF5	PRAD	chr14	103803076	103803076	C	T	Missense_Mutation	p.R73C	1
EIF5	LIHC	chr14	103803078	103803078	T	C	Silent	p.R73R	1
EIF5	HNSC	chr14	103802212	103802212	C	G	Silent		1
EIF5	LUAD	chr14	103804719	103804719	C	A	Silent	p.G165G	1
EIF5	LUSC	chr14	103802201	103802201	T	C	Missense_Mutation	p.S2P	1
EIF5	STAD	chr14	103803484	103803484	A	T	Missense_Mutation	p.N120I	1
EIF5	BLCA	chr14	103804704	103804704	G	A	Silent	p.K160K	1
EIF5	KIRC	chr14	103805214	103805214	T	A	Missense_Mutation	p.L243H	1
EIF5	PRAD	chr14	103806053	103806053	G	C	Missense_Mutation	p.Q328H	1
EIF5	CESC	chr14	103806838	103806838	G	T	Missense_Mutation		1
EIF5	HNSC	chr14	103802403	103802403	G	A	Missense_Mutation		1
EIF5	LUSC	chr14	103802424	103802424	G	A	Missense_Mutation	p.V42I	1
EIF5	THYM	chr14	103804757	103804759	CAC	-	In_Frame_Del	p.P182in_frame_del	1
EIF5	BLCA	chr14	103803037	103803037	G	T	Nonsense_Mutation	p.E60*	1
EIF5	READ	chr14	103802222	103802222	G	A	Missense_Mutation	p.V9M	1
EIF5	SKCM	chr14	103807359	103807359	G	T	Missense_Mutation	p.K422N	1
EIF5	LUSC	chr14	103805111	103805111	G	T	Nonsense_Mutation	p.E209*	1
EIF5	BLCA	chr14	103805628	103805628	G	C	Missense_Mutation	p.K288N	1
EIF5	READ	chr14	103803023	103803023	A	C	Missense_Mutation	p.K55T	1
EIF5	COAD	chr14	103803130	103803130	G	T	Nonsense_Mutation	p.G91X	1
EIF5	LIHC	chr14	103802252	103802252	C	-	Frame_Shift_Del	p.P19fs	1
EIF5	BLCA	chr14	103802407	103802407	T	C	Missense_Mutation		1
EIF5	HNSC	chr14	103802403	103802403	G	A	Missense_Mutation	p.V35I	1
EIF5	SKCM	chr14	103806806	103806806	C	T	Missense_Mutation	p.R372C	1
EIF5	LUSC	chr14	103802453	103802453	G	T	Silent	p.Y52_splice	1
EIF5	BLCA	chr14	103802255	103802255	C	T	Missense_Mutation	p.R20C	1

Copy number variation (CNV) of EIF5
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across EIF5
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
102375	N/A	BI058894	AKIP1	chr11	8941010	-	EIF5	chr14	103810593	-
102375	LIHC	TCGA-RC-A7SF-01A	DICER1	chr14	95623567	-	EIF5	chr14	103803453	+
102375	LUSC	TCGA-56-8629-01A	DYNC1H1	chr14	102517128	-	EIF5	chr14	103805509	+
66118	N/A	DB066453	EIF5	chr14	103804311	+	BOP1	chr8	145505610	-
101899	SARC	TCGA-DX-A6YS-01A	EIF5	chr14	103807462	+	CTAGE5	chr14	39796068	+
102375	N/A	AA225558	EIF5	chr14	103803012	-	EIF5	chr14	103806140	-
91319	KIRP	TCGA-MH-A855-01A	EIF5	chr14	103800934	+	NOTCH2	chr1	120465069	-
78687	N/A	AV684282	EIF5	chr14	103809508	+	RUNX1T1	chr8	93040512	-
102375	GBM	TCGA-14-1034-01A	FAF1	chr1	51048290	-	EIF5	chr14	103805509	+
102375	N/A	AI133642	ITPR2	chr12	26854081	+	EIF5	chr14	103800574	+
102375	LUSC	TCGA-85-A53L-01A	MARK3	chr14	103871604	+	EIF5	chr14	103801990	+
102375	LUSC	TCGA-LA-A7SW-01A	MARK3	chr14	103852417	+	EIF5	chr14	103801990	+
102375	N/A	BM833559	REV1	chr2	100019515	-	EIF5	chr14	103804688	+
102375	N/A	BM145228	RUNX1T1	chr8	93040496	+	EIF5	chr14	103809508	-
102375	N/A	BM970344	RUNX1T1	chr8	93040512	+	EIF5	chr14	103809508	-
102375	STAD	TCGA-CD-A486-01A	SYNE2	chr14	64644201	+	EIF5	chr14	103806764	+
102379	Non-Cancer	TCGA-KN-8437-11A	ZNF562	chr19	9771395	-	EIF5	chr14	103803013	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type	Translation factor	Coefficent	Hazard ratio	Wald test pval	Likelihool ratio pval	Logrank test pval	# samples
LUAD	EIF5	1.40687173112614	0.341368609176307	0.000833867637625439	0.00108690842797081	0.0008136377110391	564
LUAD	EIF5	1.40687173112614	0.341368609176307	0.000833867637625439	0.00108690842797081	0.0008136377110391	564
CHOL	EIF5	4.33941391797597	1.46773929705231	0.00175025915738231	0.00169609698305979	0.00126273777168162	45
SKCM	EIF5	1.40869915821614	0.342666695723175	0.00195673278688356	0.00206333634332756	0.00197879374134415	462
SKCM	EIF5	1.40869915821614	0.342666695723175	0.00195673278688356	0.00206333634332756	0.00197879374134415	462
PAAD	EIF5	1.66978853938616	0.512696995289217	0.00953359707762738	0.00906305556298542	0.00959191507781079	182
PAAD	EIF5	1.66978853938616	0.512696995289217	0.00953359707762738	0.00906305556298542	0.00959191507781079	182
MESO	EIF5	2.60852659297405	0.958785538166334	0.00987997567514435	0.0101954345835317	0.00946340471182854	85
MESO	EIF5	2.60852659297405	0.958785538166334	0.00987997567514435	0.0101954345835317	0.00946340471182854	85
PCPG	EIF5	0.0844239614308262	-2.47190401446427	0.0136085913349859	0.0145904430159991	0.0258614354571664	185
PCPG	EIF5	0.0844239614308262	-2.47190401446427	0.0136085913349859	0.0145904430159991	0.0258614354571664	185
BRCA	EIF5	0.740859568135791	-0.299944188332449	0.0137548490528297	0.0121777709755262	0.0136925646626218	1200
UVM	EIF5	2.84802019533272	1.04662408458243	0.0222014563759515	0.0195496901837702	0.0211849869686877	80
LUAD	EIF5	1.29166100228117	0.255928988796881	0.0227337189814032	0.0231926193848548	0.0227899876295015	564
LUAD	EIF5	1.29166100228117	0.255928988796881	0.0227337189814032	0.0231926193848548	0.0227899876295015	564
KIRP	EIF5	1.66972586176885	0.512659458324389	0.0260009551708548	0.0290869159997461	0.0295162853990932	320
KIRP	EIF5	1.66972586176885	0.512659458324389	0.0260009551708548	0.0290869159997461	0.0295162853990932	320
UCEC	EIF5	1.82818799247513	0.603325308266735	0.0337783680710996	0.0383482436386109	0.0332196616655047	188
LUSC	EIF5	0.775447692013619	-0.254314749299863	0.0345542906580446	0.0344610051581346	0.0346193185912152	545
SARC	EIF5	1.53187056983145	0.426489583305163	0.0391108351493416	0.0427751545589876	0.0401168460929581	265
MESO	EIF5	1.64802987639928	0.499580560206014	0.0396409443447726	0.0381750442110044	0.0394916556190555	85
MESO	EIF5	1.64802987639928	0.499580560206014	0.0396409443447726	0.0381750442110044	0.0394916556190555	85
KIRC	EIF5	1.99232454096298	0.6893020680622	1.8550616665908e-09	8.65268273158306e-09	2.24114963303043e-09	604
KIRC	EIF5	1.99232454096298	0.6893020680622	1.8550616665908e-09	8.65268273158306e-09	2.24114963303043e-09	604
KIRC	EIF5	1.67415463933087	0.515308344939886	5.51012794953513e-05	6.43339323822388e-05	6.93817562809722e-05	604
KIRC	EIF5	1.67415463933087	0.515308344939886	5.51012794953513e-05	6.43339323822388e-05	6.93817562809722e-05	604
LIHC	EIF5	1.7687222822934	0.570257411498439	5.75546749088667e-05	9.64724129408289e-05	5.66901840201561e-05	417
LIHC	EIF5	1.7687222822934	0.570257411498439	5.75546749088667e-05	9.64724129408289e-05	5.66901840201561e-05	417

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
BLCA	EIF5	0.000590744865010822	0.017
MESO	EIF5	0.0095654642596221	0.26
KICH	EIF5	0.0239719496926781	0.62

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUAD	EIF5	0.00779272064218482	0.25
BRCA	EIF5	0.00539799963724863	0.18
OV	EIF5	0.046521409776491	1

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0036341	Schizophrenia	1	CTD_human