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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: ELAVL4 (NCBI Gene ID:1996)

Gene Summary

Gene Summary

Gene Information	Gene Name: ELAVL4
	Gene ID: 1996
	Gene Symbol	ELAVL4
	Gene ID	1996
	Gene Name	ELAV like RNA binding protein 4
	Synonyms	HUD\|PNEM
	Cytomap	1p33-p32.3
	Type of Gene	protein-coding
	Description	ELAV-like protein 4ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)ELAV like neuron-specific RNA binding protein 4Hu antigen Dparaneoplastic encephalomyelitis antigen HuD
	Modification date	20200320
	UniProtAcc	P26378

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0005840	Ribosome
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
ELAVL4	(0 - 67.6]

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Translation Studies in PubMed

We searched PubMed using 'ELAVL4[title] AND translation [title] AND human.'

Gene	Title	PMID
ELAVL4	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000371823	50642760	50642864	Frame-shift
ENST00000371823	50659436	50659590	Frame-shift
ENST00000371823	50663100	50663139	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000371823	50663100	50663139	1608	959	997	380	245	257

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
P26378	245	257	1	380	Chain	ID=PRO_0000081583;Note=ELAV-like protein 4

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
STAD	ELAVL4	-4.8156917527045	0.00879816571250558
KIRC	ELAVL4	-1.00392229844369	5.67077560181782e-08
LUAD	ELAVL4	-3.36373499023005	6.5815976201703e-06

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
LGG	ELAVL4	2	3	0.0225771605203018	0.545617612183213	0.669975611611104	-0.194268287393171	-0.275818335724168
LUAD	ELAVL4	2	3	0.00500578915107706	0.527880494821634	0.666390393356644	-0.159213638709565	-0.0458339064799172

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
PRAD	ELAVL4	3	2	0.00977432016947184	0.664489387464387	0.483625	-0.12606664160476	-0.39004258524631

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
SKCM	ELAVL4	-0.021802303	0.024972724
THYM	ELAVL4	-0.049540085	0.025044505

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with ELAVL4 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
COAD	Cell metabolism gene	ELAVL4	SNAP25	0.801970724	3.71E-75
COAD	Cell metabolism gene	ELAVL4	GNAO1	0.805557589	2.58E-76
COAD	Cell metabolism gene	ELAVL4	ST8SIA3	0.859116233	3.80E-97
COAD	CGC	ELAVL4	CTNND2	0.800489292	1.10E-74
COAD	CGC	ELAVL4	CDH10	0.807939496	4.25E-77
COAD	CGC	ELAVL4	ATP2B3	0.811273226	3.26E-78
COAD	CGC	ELAVL4	PHOX2B	0.885286817	9.29E-111
COAD	IUPHAR	ELAVL4	PTPRZ1	0.804195766	7.14E-76
COAD	IUPHAR	ELAVL4	ATP2B3	0.811273226	3.26E-78
COAD	IUPHAR	ELAVL4	GABRG2	0.831627256	1.56E-85
COAD	IUPHAR	ELAVL4	SLC18A3	0.832499084	7.21E-86
COAD	IUPHAR	ELAVL4	SLC5A7	0.842172747	1.01E-89
COAD	IUPHAR	ELAVL4	PCSK2	0.85009185	4.45E-93
COAD	IUPHAR	ELAVL4	SLC7A14	0.88737437	5.51E-112
COAD	TF	ELAVL4	FOXD3	0.807728493	4.99E-77
COAD	TF	ELAVL4	SOX10	0.832340479	8.30E-86
COAD	TF	ELAVL4	PHOX2A	0.862116574	1.46E-98
COAD	TF	ELAVL4	PHOX2B	0.885286817	9.29E-111
COAD	TSG	ELAVL4	FOXD3	0.807728493	4.99E-77
COAD	TSG	ELAVL4	CMTM5	0.812297715	1.47E-78
COAD	TSG	ELAVL4	PHOX2A	0.862116574	1.46E-98
GBM	Epifactor	ELAVL4	ACTL6B	0.819315004	6.34E-43
GBM	TF	ELAVL4	SCRT1	0.822733763	1.46E-43
PAAD	Cell metabolism gene	ELAVL4	GPR119	0.809704368	9.22E-44
PAAD	Cell metabolism gene	ELAVL4	SNAP25	0.811440507	4.38E-44
PAAD	Cell metabolism gene	ELAVL4	GNAO1	0.840235761	5.41E-50
PAAD	CGC	ELAVL4	CDH10	0.805998157	4.41E-43
PAAD	CGC	ELAVL4	FAM135B	0.815483518	7.50E-45
PAAD	Epifactor	ELAVL4	ACTL6B	0.811591698	4.10E-44
PAAD	IUPHAR	ELAVL4	SLC4A10	0.801814699	2.48E-42
PAAD	IUPHAR	ELAVL4	KCNH6	0.805562664	5.29E-43
PAAD	IUPHAR	ELAVL4	SLC6A4	0.807969644	1.93E-43
PAAD	IUPHAR	ELAVL4	GPR119	0.809704368	9.22E-44
PAAD	IUPHAR	ELAVL4	KCNB2	0.809747752	9.05E-44
PAAD	IUPHAR	ELAVL4	PCSK2	0.811126948	5.01E-44
PAAD	IUPHAR	ELAVL4	SLC6A17	0.811374736	4.50E-44
PAAD	IUPHAR	ELAVL4	GRIA3	0.814712741	1.05E-44
PAAD	IUPHAR	ELAVL4	GJD2	0.815386702	7.82E-45
PAAD	IUPHAR	ELAVL4	MAP3K15	0.815540481	7.31E-45
PAAD	IUPHAR	ELAVL4	GABRG2	0.818349466	2.09E-45
PAAD	IUPHAR	ELAVL4	CACNA1B	0.852984086	5.36E-53
PAAD	IUPHAR	ELAVL4	GRIA2	0.861398375	3.86E-55
PAAD	IUPHAR	ELAVL4	SLC7A14	0.883238978	1.97E-61
PAAD	IUPHAR	ELAVL4	CHRNB2	0.886370651	1.95E-62
PAAD	Kinase	ELAVL4	MAP3K15	0.815540481	7.31E-45
PAAD	TF	ELAVL4	INSM1	0.804779886	7.32E-43
PAAD	TF	ELAVL4	NEUROD1	0.807516872	2.33E-43
PAAD	TF	ELAVL4	MYT1L	0.830842325	6.06E-48
PAAD	TF	ELAVL4	ST18	0.85904602	1.58E-54
PAAD	TF	ELAVL4	RFX6	0.862921514	1.53E-55
PAAD	TSG	ELAVL4	DUSP26	0.805742434	4.90E-43
READ	CGC	ELAVL4	PHOX2B	0.846098042	6.62E-30
READ	IUPHAR	ELAVL4	CNGA3	0.802758753	7.26E-25
READ	IUPHAR	ELAVL4	SLC5A7	0.831180339	5.20E-28
READ	IUPHAR	ELAVL4	SLC7A14	0.843396646	1.51E-29
READ	TF	ELAVL4	PHOX2A	0.819717968	1.12E-26
READ	TF	ELAVL4	SOX10	0.839508299	4.80E-29
READ	TF	ELAVL4	PHOX2B	0.846098042	6.62E-30
READ	TSG	ELAVL4	FHL1	0.816456252	2.59E-26
READ	TSG	ELAVL4	PHOX2A	0.819717968	1.12E-26

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
BRCA	ELAVL4	CSF2RA	-2.51006529885605	0.000111245050869078
HNSC	ELAVL4	G3BP1	1.15470167292163	0.000481783007217019
BLCA	ELAVL4	GNG3	-2.0595779213728	0.002838134765625
THCA	ELAVL4	CSF2RA	-1.23391067811326	0.00492925389458784
THCA	ELAVL4	USP24	1.05550382024404	0.00650758354344202
CHOL	ELAVL4	GAP43	-1.65061283677245	0.01171875
UCEC	ELAVL4	LGALS4	1.36665298781971	0.015625
HNSC	ELAVL4	GAP43	-5.42580454145074	0.0291841810949336
ESCA	ELAVL4	EIF4A1	-1.24538073199285	0.0419921875
KIRC	ELAVL4	USP24	-1.91855601947194	1.38674564399926e-11
PRAD	ELAVL4	G3BP1	-4.29883961189402	2.3360983838936e-06
LUAD	ELAVL4	GAP43	-1.37717814606977	3.39403697895003e-06
LUSC	ELAVL4	CSF2RA	-7.73687062613045	4.28240904037329e-08
THCA	ELAVL4	NRN1	1.87891824458944	4.34082003868401e-07
BRCA	ELAVL4	NRN1	-2.78079620697682	5.43746186277972e-31
STAD	ELAVL4	G3BP1	-3.96377290273826	6.0301274061203e-05
BRCA	ELAVL4	IGF2BP1	-1.119264636586	6.55843695441879e-13
BRCA	ELAVL4	GNG3	-1.26523755136054	6.77131714453856e-09
KICH	ELAVL4	EIF4A1	1.14485583309571	8.16583633422851e-06
LUSC	ELAVL4	NRN1	-1.88041807180197	9.83302840544139e-05

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with ELAVL4

EWSR1, NXF1, PHF20L1, DGUOK, NTRK1, Hnrnph1, Sfpq, G3bp1, Igf2bp1, IGF2BP1, SART3, STAU1, FBXW11, SYNCRIP, VCP, PPT1, CSK, Smn1, ATP8B4, ADAMTS18, CSNK2A1, TUB, RNF41, CCDC140, FAU, RPL26L1, ZC3H11A, E4F1, PNRC2, GOLGA8A, H2AFB2, RPL19,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
ELAVL4	chr1	50610767	G	A	single_nucleotide_variant	Uncertain_significance	High_myopia	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
ELAVL4	SKCM	chr1	50610836	50610836	G	A	Missense_Mutation	p.E73K	5
ELAVL4	SKCM	chr1	50610686	50610686	G	A	Missense_Mutation	p.G23R	4
ELAVL4	PAAD	chr1	50642759	50642759	A	G	Splice_Site		4
ELAVL4	COAD	chr1	50659454	50659454	G	A	Silent	p.P124P	4
ELAVL4	HNSC	chr1	50659494	50659494	G	A	Missense_Mutation	p.G138S	3
ELAVL4	HNSC	chr1	50610702	50610702	A	G	Missense_Mutation	p.N28S	3
ELAVL4	COAD	chr1	50666695	50666695	C	T	Missense_Mutation	p.R316C	3
ELAVL4	SKCM	chr1	50661436	50661436	C	T	Missense_Mutation	p.H238Y	3
ELAVL4	BLCA	chr1	50666804	50666804	G	C	Missense_Mutation		3
ELAVL4	SKCM	chr1	50666819	50666819	C	T	Missense_Mutation	p.S357F	3
ELAVL4	BLCA	chr1	50642818	50642818	C	T	Missense_Mutation	p.A103V	3
ELAVL4	PRAD	chr1	50642827	50642827	C	T	Missense_Mutation	p.T106I	3
ELAVL4	SKCM	chr1	50661245	50661245	G	A	Missense_Mutation	p.G174E	2
ELAVL4	COAD	chr1	50666682	50666682	C	T	Silent	p.N311N	2
ELAVL4	LIHC	chr1	50663139	50663139	G	-	Splice_Site	p.R258_splice	2
ELAVL4	SARC	chr1	50575636	50575636	G	A	Missense_Mutation		2
ELAVL4	CESC	chr1	50659540	50659540	C	T	Missense_Mutation		2
ELAVL4	LIHC	chr1	50666499	50666499	C	-	Frame_Shift_Del	p.V269fs	2
ELAVL4	SKCM	chr1	50666517	50666517	C	T	Silent	p.P275P	2
ELAVL4	CESC	chr1	50661260	50661260	G	A	Missense_Mutation		2
ELAVL4	LAML	chr1	50348217	50348217	G	A	Silent	p.L6	2
ELAVL4	COAD	chr1	50666785	50666785	G	A	Missense_Mutation	p.G346R	2
ELAVL4	HNSC	chr1	50666515	50666515	C	T	Missense_Mutation		2
ELAVL4	SKCM	chr1	50666588	50666588	G	A	Missense_Mutation	p.G280E	2
ELAVL4	ACC	chr1	50610817	50610817	C	T	Silent	p.F66F	2
ELAVL4	HNSC	chr1	50661352	50661352	G	T	Missense_Mutation	p.A210S	2
ELAVL4	UCEC	chr1	50572035	50572035	C	T	Silent	p.V10	2
ELAVL4	BLCA	chr1	50661283	50661283	G	A	Missense_Mutation	p.E187K	2
ELAVL4	SKCM	chr1	50666631	50666631	C	T	Silent	p.S294S	2
ELAVL4	ACC	chr1	50659488	50659488	G	T	Missense_Mutation	p.V136F	2
ELAVL4	SKCM	chr1	50659567	50659567	G	A	Missense_Mutation	p.R162Q	2
ELAVL4	UCEC	chr1	50659454	50659454	G	A	Silent	p.P141	2
ELAVL4	BLCA	chr1	50610812	50610812	C	T	Missense_Mutation	p.L65F	2
ELAVL4	SKCM	chr1	50610797	50610797	G	A	Missense_Mutation	p.E60K	2
ELAVL4	STAD	chr1	50666501	50666501	C	T	Missense_Mutation		2
ELAVL4	ACC	chr1	50659584	50659584	G	T	Missense_Mutation	p.V168F	2
ELAVL4	LUAD	chr1	50666841	50666841	C	A	Missense_Mutation	p.H364Q	2
ELAVL4	UCEC	chr1	50659482	50659482	C	T	Missense_Mutation	p.L151F	2
ELAVL4	SKCM	chr1	50661416	50661416	G	A	Missense_Mutation	p.R231Q	2
ELAVL4	HNSC	chr1	50666696	50666696	G	A	Missense_Mutation	p.R330H	2
ELAVL4	UCEC	chr1	50661235	50661235	G	A	Missense_Mutation	p.V188M	2
ELAVL4	HNSC	chr1	50659453	50659453	C	T	Missense_Mutation	p.P124L	2
ELAVL4	SKCM	chr1	50572027	50572027	G	A	Missense_Mutation	p.E8K	2
ELAVL4	SKCM	chr1	50661409	50661409	C	T	Missense_Mutation	p.P229S	2
ELAVL4	ESCA	chr1	50572048	50572048	A	C	Silent		2
ELAVL4	UCEC	chr1	50661349	50661349	T	G	Missense_Mutation	p.F226V	2
ELAVL4	SKCM	chr1	50666738	50666738	C	T	Missense_Mutation	p.T330I	2
ELAVL4	LUAD	chr1	50610738	50610738	C	A	Missense_Mutation	p.T40N	2
ELAVL4	LUAD	chr1	50659526	50659526	G	A	Silent	p.L148L	2
ELAVL4	BLCA	chr1	50610766	50610766	C	T	Silent	p.I49I	2
ELAVL4	UCEC	chr1	50666494	50666494	C	T	Missense_Mutation	p.P263S	2
ELAVL4	HNSC	chr1	50663122	50663122	G	A	Missense_Mutation	p.M252I	2
ELAVL4	BLCA	chr1	50642818	50642818	C	T	Missense_Mutation		2
ELAVL4	UCEC	chr1	50666546	50666546	G	A	Missense_Mutation	p.G283E	2
ELAVL4	SKCM	chr1	50610820	50610820	G	A	Silent	p.G67G	2
ELAVL4	HNSC	chr1	50642774	50642774	G	T	Silent	p.G88G	2
ELAVL4	KICH	chr1	50659551	50659551	C	T	Missense_Mutation	p.R157C	2
ELAVL4	BLCA	chr1	50642770	50642770	T	G	Nonsense_Mutation	p.L87*	2
ELAVL4	ESCA	chr1	50572048	50572048	A	C	Silent	p.R15R	2
ELAVL4	LIHC	chr1	50610752	50610752	A	-	Frame_Shift_Del	p.K45fs	2
ELAVL4	STAD	chr1	50659454	50659454	G	A	Silent	p.P141P	1
ELAVL4	ACC	chr1	50610817	50610817	C	T	Silent	p.F83F	1
ELAVL4	BLCA	chr1	50666658	50666658	T	C	Silent	p.F317F	1
ELAVL4	STAD	chr1	50642827	50642827	C	G	Missense_Mutation	p.T106S	1
ELAVL4	LUAD	chr1	50610800	50610800	G	T	Nonsense_Mutation	p.E61*	1
ELAVL4	KIRC	chr1	50610859	50610859	C	A	Missense_Mutation	p.D97E	1
ELAVL4	LUAD	chr1	50666531	50666531	C	A	Missense_Mutation	p.P261Q	1
ELAVL4	LUSC	chr1	50642799	50642799	C	G	Missense_Mutation	p.P97A	1
ELAVL4	SKCM	chr1	50666528	50666528	C	T	Missense_Mutation	p.S260F	1
ELAVL4	BLCA	chr1	50666599	50666599	T	C	Missense_Mutation		1
ELAVL4	UCEC	chr1	50661234	50661234	A	G	Silent	p.G170_splice	1
ELAVL4	BLCA	chr1	50666550	50666550	G	C	Missense_Mutation	p.M267I	1
ELAVL4	ESCA	chr1	50610816	50610816	T	G	Missense_Mutation	p.F83C	1
ELAVL4	HNSC	chr1	50666796	50666796	G	T	Silent		1
ELAVL4	SKCM	chr1	50661354	50661354	C	T	Silent	p.A210A	1
ELAVL4	STAD	chr1	50666792	50666792	G	A	Missense_Mutation	p.R365H	1
ELAVL4	ACC	chr1	50659488	50659488	G	T	Missense_Mutation	p.V153F	1
ELAVL4	STAD	chr1	50661259	50661259	C	T	Missense_Mutation	p.R179C	1
ELAVL4	LUAD	chr1	50666503	50666503	C	A	Missense_Mutation	p.P271T	1
ELAVL4	KIRP	chr1	50666791	50666791	C	A	Missense_Mutation		1
ELAVL4	LUAD	chr1	50666530	50666530	C	A	Missense_Mutation	p.P261T	1
ELAVL4	OV	chr1	50439379	50439379	G	A	Missense_Mutation		1
ELAVL4	SKCM	chr1	50642778	50642778	G	A	Missense_Mutation	p.G90R	1
ELAVL4	BLCA	chr1	50666597	50666597	G	C	Missense_Mutation		1
ELAVL4	UCEC	chr1	50610771	50610771	A	G	Missense_Mutation	p.N51S	1
ELAVL4	BLCA	chr1	50666599	50666599	T	C	Missense_Mutation	p.C284R	1
ELAVL4	ESCA	chr1	50661318	50661318	C	T	Silent	p.P215P	1
ELAVL4	HNSC	chr1	50610702	50610702	A	G	Missense_Mutation		1
ELAVL4	SARC	chr1	50575636	50575636	G	A	Splice_Site	p.M8_splice	1
ELAVL4	SKCM	chr1	50661407	50661407	C	T	Missense_Mutation	p.S228F	1
ELAVL4	STAD	chr1	50659494	50659494	G	A	Missense_Mutation	p.G155S	1
ELAVL4	ACC	chr1	50659584	50659584	G	T	Missense_Mutation	p.V185F	1
ELAVL4	STAD	chr1	50661335	50661335	C	T	Missense_Mutation	p.P204L	1
ELAVL4	HNSC	chr1	50666796	50666796	G	T	Silent	p.L349L	1
ELAVL4	LUAD	chr1	50610672	50610672	C	A	Missense_Mutation	p.S18Y	1
ELAVL4	LUAD	chr1	50661329	50661329	C	A	Missense_Mutation	p.T202K	1
ELAVL4	PAAD	chr1	50663102	50663102	C	A	Missense_Mutation		1
ELAVL4	SKCM	chr1	50666809	50666809	T	C	Silent	p.L354L	1
ELAVL4	BLCA	chr1	50661283	50661283	G	A	Missense_Mutation		1
ELAVL4	UCEC	chr1	50666727	50666727	C	T	Silent	p.F340F	1
ELAVL4	BLCA	chr1	50666597	50666597	G	C	Missense_Mutation	p.W283S	1
ELAVL4	ESCA	chr1	50610816	50610816	T	G	Missense_Mutation	p.F66C	1
ELAVL4	LIHC	chr1	50666721	50666721	G	-	Frame_Shift_Del	p.K324fs	1
ELAVL4	SKCM	chr1	50666721	50666721	G	A	Silent	p.K324K	1
ELAVL4	STAD	chr1	50642827	50642827	C	G	Missense_Mutation	p.T123S	1
ELAVL4	CESC	chr1	50661260	50661260	G	A	Missense_Mutation	p.R184H	1
ELAVL4	STAD	chr1	50610682	50610682	C	T	Silent	p.S21S	1
ELAVL4	LUAD	chr1	50610673	50610673	C	A	Silent	p.S18S	1
ELAVL4	LGG	chr1	50642804	50642804	G	T	Missense_Mutation	p.K98N	1
ELAVL4	LUAD	chr1	50659497	50659497	C	A	Missense_Mutation	p.L139I	1
ELAVL4	SKCM	chr1	50661331	50661331	G	A	Missense_Mutation	p.E203K	1
ELAVL4	BLCA	chr1	50610812	50610812	C	T	Missense_Mutation		1
ELAVL4	ESCA	chr1	50572048	50572048	A	C	Silent	p.R15	1
ELAVL4	ESCA	chr1	50661318	50661318	C	T	Silent	p.P198P	1
ELAVL4	HNSC	chr1	50642774	50642774	G	T	Silent		1
ELAVL4	LIHC	chr1	50661407	50661407	C	-	Frame_Shift_Del	p.S228fs	1
ELAVL4	SKCM	chr1	50666700	50666700	C	-	Frame_Shift_Del	p.D317fs	1
ELAVL4	SKCM	chr1	50666517	50666517	C	T	Silent	p.P270P	1
ELAVL4	STAD	chr1	50610646	50610646	G	T	Missense_Mutation	p.E26D	1
ELAVL4	CESC	chr1	50659540	50659540	C	T	Missense_Mutation	p.S158L	1
ELAVL4	TGCT	chr1	50642764	50642765	AG	-	Frame_Shift_Del		1
ELAVL4	HNSC	chr1	50659554	50659568	ATCATCACCTCACGA	-	In_Frame_Del	p.IITSR158del	1
ELAVL4	LUAD	chr1	50610781	50610781	C	A	Silent	p.P54P	1
ELAVL4	LGG	chr1	50642804	50642804	G	T	Missense_Mutation		1
ELAVL4	LUAD	chr1	50659564	50659564	C	A	Nonsense_Mutation	p.S161*	1
ELAVL4	PAAD	chr1	50642759	50642759	A	G	Splice_Site	.	1
ELAVL4	ESCA	chr1	50610816	50610816	T	G	Missense_Mutation	p.F71C	1
ELAVL4	GBM	chr1	50610767	50610767	G	A	Missense_Mutation	p.V50I	1
ELAVL4	HNSC	chr1	50663122	50663122	G	A	Missense_Mutation		1
ELAVL4	LIHC	chr1	50666528	50666528	C	-	Frame_Shift_Del	p.S260fs	1
ELAVL4	STAD	chr1	50666501	50666501	C	T	Missense_Mutation	p.P270L	1
ELAVL4	CHOL	chr1	50610818	50610818	G	A	Missense_Mutation	p.G84R	1
ELAVL4	TGCT	chr1	50642764	50642765	AG	-	Frame_Shift_Del	p.102_102del	1
ELAVL4	HNSC	chr1	50661318	50661319	-	A	Frame_Shift_Ins	p.R199fs	1
ELAVL4	LIHC	chr1	50661239	50661239	C	A	Missense_Mutation		1
ELAVL4	LUAD	chr1	50659500	50659500	C	-	Frame_Shift_Del	p.P140fs	1
ELAVL4	PAAD	chr1	50663102	50663102	C	A	Missense_Mutation	p.L263M	1
ELAVL4	SKCM	chr1	50572066	50572066	G	A	Splice_Site		1
ELAVL4	BLCA	chr1	50661265	50661265	G	C	Missense_Mutation		1
ELAVL4	ESCA	chr1	50661318	50661318	C	T	Silent	p.P203	1
ELAVL4	BLCA	chr1	50666804	50666804	G	C	Missense_Mutation	p.R352T	1
ELAVL4	HNSC	chr1	50659494	50659494	G	A	Missense_Mutation		1
ELAVL4	HNSC	chr1	50659554	50659568	ATCATCACCTCACGA	-	In_Frame_Del		1
ELAVL4	LIHC	chr1	50661253	50661253	T	-	Frame_Shift_Del	p.F177fs	1
ELAVL4	STAD	chr1	50666501	50666501	C	T	Missense_Mutation	p.P265L	1
ELAVL4	SKCM	chr1	50666700	50666700	C	-	Frame_Shift_Del	p.D320fs	1
ELAVL4	BLCA	chr1	50666507	50666507	C	T	Missense_Mutation		1
ELAVL4	COAD	chr1	50610725	50610725	C	T	Nonsense_Mutation	p.Q36X	1
ELAVL4	TGCT	chr1	50642764	50642765	AG	-	Frame_Shift_Del	p.Q85fs	1
ELAVL4	LUAD	chr1	50666509	50666509	G	T	Missense_Mutation	p.A273S	1
ELAVL4	LIHC	chr1	50663104	50663104	G	T	Silent		1
ELAVL4	LUAD	chr1	50666841	50666841	C	A	Missense_Mutation	p.H378Q	1
ELAVL4	PAAD	chr1	50663102	50663102	C	A	Splice_Site	p.L246_splice	1
ELAVL4	SKCM	chr1	50666604	50666604	C	T	Silent	p.I285I	1
ELAVL4	BLCA	chr1	50666507	50666507	C	T	Missense_Mutation	p.S272F	1
ELAVL4	ESCA	chr1	50663196	50663197	-	T	RNA	NULL	1
ELAVL4	STAD	chr1	50661335	50661335	C	T	Missense_Mutation	p.P221L	1
ELAVL4	BLCA	chr1	50661353	50661353	C	T	Missense_Mutation	p.A210V	1
ELAVL4	HNSC	chr1	50659453	50659453	C	T	Missense_Mutation		1
ELAVL4	STAD	chr1	50659546	50659546	A	G	Missense_Mutation	p.Y155C	1
ELAVL4	LIHC	chr1	50661360	50661360	C	-	Frame_Shift_Del	p.N212fs	1
ELAVL4	HNSC	chr1	50666796	50666796	G	T	Silent	p.L363L	1
ELAVL4	LUAD	chr1	50661258	50661258	C	A	Silent	p.I178I	1
ELAVL4	BLCA	chr1	50666658	50666658	T	C	Silent		1
ELAVL4	THYM	chr1	50666545	50666545	G	A	Missense_Mutation	p.G283R	1
ELAVL4	LIHC	chr1	50572025	50572025	G	A	Missense_Mutation	p.R7K	1
ELAVL4	PAAD	chr1	50663102	50663102	C	A	Splice_Site	p.L246M	1
ELAVL4	SKCM	chr1	50610690	50610690	C	T	Missense_Mutation	p.P24L	1
ELAVL4	BLCA	chr1	50666658	50666658	T	C	Silent	p.F303F	1
ELAVL4	STAD	chr1	50659546	50659546	A	G	Missense_Mutation	p.Y172C	1
ELAVL4	BLCA	chr1	50661265	50661265	G	C	Missense_Mutation	p.D181H	1
ELAVL4	HNSC	chr1	50666696	50666696	G	A	Missense_Mutation		1
ELAVL4	STAD	chr1	50663114	50663114	C	T	Missense_Mutation	p.L250F	1
ELAVL4	HNSC	chr1	50666696	50666696	G	A	Missense_Mutation	p.R316H	1
ELAVL4	LIHC	chr1	50642814	50642814	A	-	Frame_Shift_Del	p.K102fs	1
ELAVL4	HNSC	chr1	50661318	50661319	-	A	Frame_Shift_Ins	p.P198fs	1
ELAVL4	SKCM	chr1	50642815	50642815	A	C	Missense_Mutation	p.K102T	1
ELAVL4	BLCA	chr1	50610766	50610766	C	T	Silent		1
ELAVL4	COAD	chr1	50661255	50661255	C	A	Missense_Mutation	p.F177L	1
ELAVL4	UCEC	chr1	50666849	50666849	G	T	Nonstop_Mutation	p.*381L	1
ELAVL4	ESCA	chr1	50610816	50610816	T	G	Missense_Mutation		1
ELAVL4	LIHC	chr1	50610679	50610679	A	G	Silent	p.T37T	1
ELAVL4	PRAD	chr1	50642827	50642827	C	T	Missense_Mutation	p.T123I	1
ELAVL4	SKCM	chr1	50659525	50659525	T	C	Missense_Mutation	p.L148P	1
ELAVL4	STAD	chr1	50666696	50666696	G	A	Missense_Mutation	p.R333H	1
ELAVL4	BLCA	chr1	50663104	50663105	-	GACAATTT	Frame_Shift_Ins	p.-249fs	1
ELAVL4	STAD	chr1	50666792	50666792	G	A	Missense_Mutation	p.R362H	1
ELAVL4	LIHC	chr1	50661322	50661322	G	-	Frame_Shift_Del	p.G200fs	1
ELAVL4	KICH	chr1	50659551	50659551	C	T	Missense_Mutation		1
ELAVL4	LUAD	chr1	50610756	50610756	C	T	Missense_Mutation	p.T46I	1
ELAVL4	LUAD	chr1	50666530	50666531	CC	AA	Missense_Mutation	p.P275K	1
ELAVL4	SKCM	chr1	50610828	50610828	G	A	Missense_Mutation	p.G70D	1
ELAVL4	COAD	chr1	50666480	50666480	G	T	Splice_Site	.	1
ELAVL4	UCEC	chr1	50610748	50610748	C	T	Silent	p.D43D	1
ELAVL4	ESCA	chr1	50661318	50661318	C	T	Silent		1
ELAVL4	HNSC	chr1	50661352	50661352	G	T	Missense_Mutation		1
ELAVL4	LIHC	chr1	50666513	50666514	-	T	Frame_Shift_Ins	p.S274fs	1
ELAVL4	PRAD	chr1	50661330	50661330	G	A	Silent	p.T202T	1
ELAVL4	SKCM	chr1	50575633	50575633	G	A	Silent	p.K7K	1
ELAVL4	STAD	chr1	50610682	50610682	C	T	Silent	p.S38S	1
ELAVL4	BLCA	chr1	50666507	50666507	C	T	Missense_Mutation	p.S267F	1
ELAVL4	STAD	chr1	50610646	50610646	G	T	Missense_Mutation	p.E9D	1
ELAVL4	LIHC	chr1	50666621	50666621	C	-	Frame_Shift_Del	p.S291fs	1
ELAVL4	LUAD	chr1	50572025	50572025	G	T	Missense_Mutation	p.R7M	1
ELAVL4	LUSC	chr1	50661265	50661265	G	A	Missense_Mutation	p.D181N	1
ELAVL4	SKCM	chr1	50666542	50666542	G	A	Missense_Mutation	p.D265N	1
ELAVL4	BLCA	chr1	50663104	50663105	-	-	Frame_Shift_Ins		1
ELAVL4	COAD	chr1	50666555	50666555	G	A	Missense_Mutation	p.S269N	1
ELAVL4	UCEC	chr1	50642763	50642763	C	T	Nonsense_Mutation	p.Q85*	1
ELAVL4	HNSC	chr1	50661318	50661319	-	-	Frame_Shift_Ins		1
ELAVL4	SKCM	chr1	50642835	50642835	G	A	Missense_Mutation	p.G109R	1

Copy number variation (CNV) of ELAVL4
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across ELAVL4
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
100632	N/A	BY798206	CDR1	chrX	139866259	+	ELAVL4	chr1	50666827	+
100632	BRCA	TCGA-E2-A1LS-01A	FOXJ3	chr1	42776721	-	ELAVL4	chr1	50642761	+
100632	N/A	CD652387	WDHD1	chr14	55457973	-	ELAVL4	chr1	50519494	-
100635	BRCA	TCGA-D8-A1JA-01A	ZCCHC11	chr1	53018603	-	ELAVL4	chr1	50642761	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	ELAVL4	0.00517697948330493	0.14
HNSC	ELAVL4	0.00712430737617619	0.19
ACC	ELAVL4	0.0145353791245345	0.38
TGCT	ELAVL4	0.0154003621562019	0.39
THYM	ELAVL4	0.0216801125409602	0.52
KIRP	ELAVL4	0.0421586237353492	0.97

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
GBM	ELAVL4	0.00846537398370798	0.27
LGG	ELAVL4	0.00170885768062573	0.056
SKCM	ELAVL4	0.0487665768678095	1
CESC	ELAVL4	0.0483963496203318	1

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source