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Center for Computational Systems Medicine
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Gene Summary

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Translation studies in PubMed

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Exon Skipping Events

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Expression

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Expression Regulation

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Associated Genes

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Protein 3D Structure

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Protein-Protein Interaction

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Mutations

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Prognostic Analysis

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Gender Association

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Age Association

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Related Drugs

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Related Diseases

Translation Factor: AKT1 (NCBI Gene ID:207)


Gene Summary

check button Gene Summary
Gene InformationGene Name: AKT1
Gene ID: 207
Gene Symbol

AKT1

Gene ID

207

Gene NameAKT serine/threonine kinase 1
SynonymsAKT|CWS6|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHA
Cytomap

14q32.33

Type of Geneprotein-coding
DescriptionRAC-alpha serine/threonine-protein kinaseAKT1mPKB alphaRAC-PK-alphaprotein kinase B alphaproto-oncogene c-Aktrac protein kinase alphaserine-threonine protein kinasev-akt murine thymoma viral oncogene homolog 1v-akt murine thymoma viral oncogene-l
Modification date20200329
UniProtAcc

P31749


check button Child GO biological process term(s) under GO:0006412
GO IDGO term
GO:0006417Regulation of translation
GO:0006412Translation


check button Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAKT1

GO:0001934

positive regulation of protein phosphorylation

19057511

HgeneAKT1

GO:0006468

protein phosphorylation

11994271|14749367|23431171

HgeneAKT1

GO:0007173

epidermal growth factor receptor signaling pathway

20878056

HgeneAKT1

GO:0016310

phosphorylation

20333297

HgeneAKT1

GO:0018105

peptidyl-serine phosphorylation

16139227

HgeneAKT1

GO:0018107

peptidyl-threonine phosphorylation

20605787

HgeneAKT1

GO:0030307

positive regulation of cell growth

19203586

HgeneAKT1

GO:0032079

positive regulation of endodeoxyribonuclease activity

20605787

HgeneAKT1

GO:0033138

positive regulation of peptidyl-serine phosphorylation

19667065

HgeneAKT1

GO:0035556

intracellular signal transduction

14749367

HgeneAKT1

GO:0035655

interleukin-18-mediated signaling pathway

21321938

HgeneAKT1

GO:0043066

negative regulation of apoptotic process

19203586

HgeneAKT1

GO:0043536

positive regulation of blood vessel endothelial cell migration

20011604

HgeneAKT1

GO:0048661

positive regulation of smooth muscle cell proliferation

21321938

HgeneAKT1

GO:0051091

positive regulation of DNA-binding transcription factor activity

19057511

HgeneAKT1

GO:0070141

response to UV-A

18483258



check button Inferred gene age of translation factor.
GeneInferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25


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Translation Studies in PubMed

check button We searched PubMed using 'AKT1[title] AND translation [title] AND human.'
GeneTitlePMID
AKT1Reactive Oxygen Species-Mediated Loss of Synaptic Akt1 Signaling Leads to Deficient Activity-Dependent Protein Translation Early in Alzheimer's Disease28264587


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Exon Skipping Events

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.
all structure

check button Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ENSTExon skip start (DNA)Exon Skip end (DNA)ORF
ENST00000349310105238701105238789Frame-shift
ENST00000402615105238701105238789Frame-shift
ENST00000407796105238701105238789Frame-shift
ENST00000554581105238701105238789Frame-shift
ENST00000554848105238701105238789Frame-shift
ENST00000555528105238701105238789Frame-shift
ENST00000349310105239214105239429Frame-shift
ENST00000402615105239214105239429Frame-shift
ENST00000407796105239214105239429Frame-shift
ENST00000554581105239214105239429Frame-shift
ENST00000554848105239214105239429Frame-shift
ENST00000555528105239214105239429Frame-shift
ENST00000349310105239791105239917In-frame
ENST00000402615105239791105239917In-frame
ENST00000407796105239791105239917In-frame
ENST00000554581105239791105239917In-frame
ENST00000554848105239791105239917In-frame
ENST00000555528105239791105239917In-frame
ENST00000349310105240248105240317In-frame
ENST00000402615105240248105240317In-frame
ENST00000407796105240248105240317In-frame
ENST00000554581105240248105240317In-frame
ENST00000554848105240248105240317In-frame
ENST00000555528105240248105240317In-frame
ENST00000349310105241412105241544In-frame
ENST00000402615105241412105241544In-frame
ENST00000407796105241412105241544In-frame
ENST00000554581105241412105241544In-frame
ENST00000554848105241412105241544In-frame
ENST00000555528105241412105241544In-frame
ENST00000349310105246424105246553In-frame
ENST00000402615105246424105246553In-frame
ENST00000407796105246424105246553In-frame
ENST00000554848105246424105246553In-frame
ENST00000555528105246424105246553In-frame
ENST000004077961052589341052590593UTR-3CDS
ENST000003493101052594631052595473UTR-3UTR

check button Exon skipping position in the amino acid sequence.
ENSTExon skip start (DNA)Exon Skip end (DNA)Len(transcript seq)Exon skip start (mRNA)Exon Skip end (mRNA)Len(amino acid seq)Exon skip start (AA)Exon Skip end (AA)
ENST000005548481052397911052399171612855980480234276
ENST0000040779610523979110523991727279781103480234276
ENST00000349310105239791105239917288311341259480234276
ENST00000555528105239791105239917308313561481480234276
ENST00000402615105239791105239917393021842309480234276
ENST00000554581105239791105239917393321842309480234276
ENST000005548481052402481052403171612786854480211234
ENST000004077961052402481052403172727909977480211234
ENST00000349310105240248105240317288310651133480211234
ENST00000555528105240248105240317308312871355480211234
ENST00000402615105240248105240317393021152183480211234
ENST00000554581105240248105240317393321152183480211234
ENST000005548481052414121052415441612588719480145189
ENST000004077961052414121052415442727711842480145189
ENST000003493101052414121052415442883867998480145189
ENST00000555528105241412105241544308310891220480145189
ENST00000402615105241412105241544393019172048480145189
ENST00000554581105241412105241544393319172048480145189
ENST0000055484810524642410524655316121993274801558
ENST0000040779610524642410524655327273224504801558
ENST0000034931010524642410524655328834786064801558
ENST0000055552810524642410524655330837008284801558
ENST000004026151052464241052465533930152816564801558

check button Potentially (partially) lost protein functional features of UniProt.
UniProtAccExon skip start (AA)Exon Skip end (AA)Function feature start (AA)Function feature end (AA)Functional feature typeFunctional feature desc.
P317492342761480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P317492112341480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P317491451891480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P3174915581480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P317492342761480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P317492112341480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P317491451891480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P3174915581480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P317492342761480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P317492112341480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P317491451891480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P3174915581480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P317492342761480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P317492112341480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P317491451891480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P317492342761480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P317492112341480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P317491451891480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P3174915581480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P317492342761480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P317492112341480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P317491451891480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P3174915581480ChainID=PRO_0000085605;Note=RAC-alpha serine/threonine-protein kinase
P3174915585108DomainNote=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
P3174915585108DomainNote=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
P3174915585108DomainNote=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
P3174915585108DomainNote=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
P3174915585108DomainNote=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145
P31749234276150408DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749211234150408DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749145189150408DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749234276150408DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749211234150408DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749145189150408DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749234276150408DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749211234150408DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749145189150408DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749234276150408DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749211234150408DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749145189150408DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749234276150408DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749211234150408DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749145189150408DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749234276150408DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749211234150408DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749145189150408DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749145189156164Nucleotide bindingNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749145189156164Nucleotide bindingNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749145189156164Nucleotide bindingNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749145189156164Nucleotide bindingNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749145189156164Nucleotide bindingNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749145189156164Nucleotide bindingNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P3174915581419RegionNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
P3174915581419RegionNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
P3174915581419RegionNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
P3174915581419RegionNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
P3174915581419RegionNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
P3174915582325RegionNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
P3174915582325RegionNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
P3174915582325RegionNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
P3174915582325RegionNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
P3174915582325RegionNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
P31749211234228230RegionNote=Inhibitor binding
P31749211234228230RegionNote=Inhibitor binding
P31749211234228230RegionNote=Inhibitor binding
P31749211234228230RegionNote=Inhibitor binding
P31749211234228230RegionNote=Inhibitor binding
P31749211234228230RegionNote=Inhibitor binding
P31749234276274274Active siteNote=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027
P31749234276274274Active siteNote=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027
P31749234276274274Active siteNote=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027
P31749234276274274Active siteNote=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027
P31749234276274274Active siteNote=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027
P31749234276274274Active siteNote=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027
P3174915585353Binding siteNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate
P3174915585353Binding siteNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate
P3174915585353Binding siteNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate
P3174915585353Binding siteNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate
P3174915585353Binding siteNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate
P31749145189161161Binding siteNote=Inhibitor%3B via amide nitrogen
P31749145189161161Binding siteNote=Inhibitor%3B via amide nitrogen
P31749145189161161Binding siteNote=Inhibitor%3B via amide nitrogen
P31749145189161161Binding siteNote=Inhibitor%3B via amide nitrogen
P31749145189161161Binding siteNote=Inhibitor%3B via amide nitrogen
P31749145189161161Binding siteNote=Inhibitor%3B via amide nitrogen
P31749145189179179Binding siteNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749145189179179Binding siteNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749145189179179Binding siteNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749145189179179Binding siteNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749145189179179Binding siteNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749145189179179Binding siteNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
P31749211234230230Binding siteNote=Inhibitor%3B via amide nitrogen
P31749211234230230Binding siteNote=Inhibitor%3B via amide nitrogen
P31749211234230230Binding siteNote=Inhibitor%3B via amide nitrogen
P31749211234230230Binding siteNote=Inhibitor%3B via amide nitrogen
P31749211234230230Binding siteNote=Inhibitor%3B via amide nitrogen
P31749211234230230Binding siteNote=Inhibitor%3B via amide nitrogen
P31749234276234234Binding siteNote=Inhibitor
P31749211234234234Binding siteNote=Inhibitor
P31749234276234234Binding siteNote=Inhibitor
P31749211234234234Binding siteNote=Inhibitor
P31749234276234234Binding siteNote=Inhibitor
P31749211234234234Binding siteNote=Inhibitor
P31749234276234234Binding siteNote=Inhibitor
P31749211234234234Binding siteNote=Inhibitor
P31749234276234234Binding siteNote=Inhibitor
P31749211234234234Binding siteNote=Inhibitor
P31749234276234234Binding siteNote=Inhibitor
P31749211234234234Binding siteNote=Inhibitor
P3174915582020Modified residueNote=N6-acetyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
P3174915582020Modified residueNote=N6-acetyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
P3174915582020Modified residueNote=N6-acetyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
P3174915582020Modified residueNote=N6-acetyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
P3174915582020Modified residueNote=N6-acetyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
P31749145189176176Modified residueNote=Phosphotyrosine%3B by TNK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20333297;Dbxref=PMID:20333297
P31749145189176176Modified residueNote=Phosphotyrosine%3B by TNK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20333297;Dbxref=PMID:20333297
P31749145189176176Modified residueNote=Phosphotyrosine%3B by TNK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20333297;Dbxref=PMID:20333297
P31749145189176176Modified residueNote=Phosphotyrosine%3B by TNK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20333297;Dbxref=PMID:20333297
P31749145189176176Modified residueNote=Phosphotyrosine%3B by TNK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20333297;Dbxref=PMID:20333297
P31749145189176176Modified residueNote=Phosphotyrosine%3B by TNK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20333297;Dbxref=PMID:20333297
P317491558162Alternative sequenceID=VSP_056180;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P317491558162Alternative sequenceID=VSP_056180;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P317491558162Alternative sequenceID=VSP_056180;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P317491558162Alternative sequenceID=VSP_056180;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P317491558162Alternative sequenceID=VSP_056180;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P3174915581717Natural variantID=VAR_055422;Note=In PROTEUSS and breast cancer%3B also detected in colorectal and ovarian cancer%3B somatic mutation%3B results in increased phosphorylation at T-308 and higher basal ubiquitination%3B the mutant protein is more efficiently recruited to the plasma membrane%3B alters phosphatidylinositiol phosphates lipid specificity of the AKT1 PH domain. E->K;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17611497,ECO:0000269|PubMed:18954143,ECO:0000269|PubMed:19713527,ECO:0000269|PubMed:21793738;Dbxref=dbSNP:rs121434592,PMID:17611497,PMID:18954143,PMID:19713527,PMID:21793738
P3174915581717Natural variantID=VAR_055422;Note=In PROTEUSS and breast cancer%3B also detected in colorectal and ovarian cancer%3B somatic mutation%3B results in increased phosphorylation at T-308 and higher basal ubiquitination%3B the mutant protein is more efficiently recruited to the plasma membrane%3B alters phosphatidylinositiol phosphates lipid specificity of the AKT1 PH domain. E->K;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17611497,ECO:0000269|PubMed:18954143,ECO:0000269|PubMed:19713527,ECO:0000269|PubMed:21793738;Dbxref=dbSNP:rs121434592,PMID:17611497,PMID:18954143,PMID:19713527,PMID:21793738
P3174915581717Natural variantID=VAR_055422;Note=In PROTEUSS and breast cancer%3B also detected in colorectal and ovarian cancer%3B somatic mutation%3B results in increased phosphorylation at T-308 and higher basal ubiquitination%3B the mutant protein is more efficiently recruited to the plasma membrane%3B alters phosphatidylinositiol phosphates lipid specificity of the AKT1 PH domain. E->K;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17611497,ECO:0000269|PubMed:18954143,ECO:0000269|PubMed:19713527,ECO:0000269|PubMed:21793738;Dbxref=dbSNP:rs121434592,PMID:17611497,PMID:18954143,PMID:19713527,PMID:21793738
P3174915581717Natural variantID=VAR_055422;Note=In PROTEUSS and breast cancer%3B also detected in colorectal and ovarian cancer%3B somatic mutation%3B results in increased phosphorylation at T-308 and higher basal ubiquitination%3B the mutant protein is more efficiently recruited to the plasma membrane%3B alters phosphatidylinositiol phosphates lipid specificity of the AKT1 PH domain. E->K;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17611497,ECO:0000269|PubMed:18954143,ECO:0000269|PubMed:19713527,ECO:0000269|PubMed:21793738;Dbxref=dbSNP:rs121434592,PMID:17611497,PMID:18954143,PMID:19713527,PMID:21793738
P3174915581717Natural variantID=VAR_055422;Note=In PROTEUSS and breast cancer%3B also detected in colorectal and ovarian cancer%3B somatic mutation%3B results in increased phosphorylation at T-308 and higher basal ubiquitination%3B the mutant protein is more efficiently recruited to the plasma membrane%3B alters phosphatidylinositiol phosphates lipid specificity of the AKT1 PH domain. E->K;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17611497,ECO:0000269|PubMed:18954143,ECO:0000269|PubMed:19713527,ECO:0000269|PubMed:21793738;Dbxref=dbSNP:rs121434592,PMID:17611497,PMID:18954143,PMID:19713527,PMID:21793738
P3174915582525Natural variantID=VAR_069791;Note=In CWS6. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23246288;Dbxref=dbSNP:rs397514644,PMID:23246288
P3174915582525Natural variantID=VAR_069791;Note=In CWS6. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23246288;Dbxref=dbSNP:rs397514644,PMID:23246288
P3174915582525Natural variantID=VAR_069791;Note=In CWS6. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23246288;Dbxref=dbSNP:rs397514644,PMID:23246288
P3174915582525Natural variantID=VAR_069791;Note=In CWS6. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23246288;Dbxref=dbSNP:rs397514644,PMID:23246288
P3174915582525Natural variantID=VAR_069791;Note=In CWS6. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23246288;Dbxref=dbSNP:rs397514644,PMID:23246288
P31749145189167167Natural variantID=VAR_051617;Note=V->A;Dbxref=dbSNP:rs11555433
P31749145189167167Natural variantID=VAR_051617;Note=V->A;Dbxref=dbSNP:rs11555433
P31749145189167167Natural variantID=VAR_051617;Note=V->A;Dbxref=dbSNP:rs11555433
P31749145189167167Natural variantID=VAR_051617;Note=V->A;Dbxref=dbSNP:rs11555433
P31749145189167167Natural variantID=VAR_051617;Note=V->A;Dbxref=dbSNP:rs11555433
P31749145189167167Natural variantID=VAR_051617;Note=V->A;Dbxref=dbSNP:rs11555433
P3174915581717MutagenesisNote=No effect on membrane localization. Loss of membrane localization%3B when associated with Q-20. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
P3174915581717MutagenesisNote=No effect on membrane localization. Loss of membrane localization%3B when associated with Q-20. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
P3174915581717MutagenesisNote=No effect on membrane localization. Loss of membrane localization%3B when associated with Q-20. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
P3174915581717MutagenesisNote=No effect on membrane localization. Loss of membrane localization%3B when associated with Q-20. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
P3174915581717MutagenesisNote=No effect on membrane localization. Loss of membrane localization%3B when associated with Q-20. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
P3174915582020MutagenesisNote=Substantial reduction of phosphorylation at T-308 and S-473%2C reduced AKT activation%2C and reduced binding to PIP3 as well as IGF1-induced membrane recruitment. Loss of membrane localization%3B when associated with K-17. K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
P3174915582020MutagenesisNote=Substantial reduction of phosphorylation at T-308 and S-473%2C reduced AKT activation%2C and reduced binding to PIP3 as well as IGF1-induced membrane recruitment. Loss of membrane localization%3B when associated with K-17. K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
P3174915582020MutagenesisNote=Substantial reduction of phosphorylation at T-308 and S-473%2C reduced AKT activation%2C and reduced binding to PIP3 as well as IGF1-induced membrane recruitment. Loss of membrane localization%3B when associated with K-17. K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
P3174915582020MutagenesisNote=Substantial reduction of phosphorylation at T-308 and S-473%2C reduced AKT activation%2C and reduced binding to PIP3 as well as IGF1-induced membrane recruitment. Loss of membrane localization%3B when associated with K-17. K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
P3174915582020MutagenesisNote=Substantial reduction of phosphorylation at T-308 and S-473%2C reduced AKT activation%2C and reduced binding to PIP3 as well as IGF1-induced membrane recruitment. Loss of membrane localization%3B when associated with K-17. K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
P3174915582020MutagenesisNote=Slight increase of phosphorylation at T-308 and S-473. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
P3174915582020MutagenesisNote=Slight increase of phosphorylation at T-308 and S-473. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
P3174915582020MutagenesisNote=Slight increase of phosphorylation at T-308 and S-473. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
P3174915582020MutagenesisNote=Slight increase of phosphorylation at T-308 and S-473. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
P3174915582020MutagenesisNote=Slight increase of phosphorylation at T-308 and S-473. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775285;Dbxref=PMID:21775285
P3174915582525MutagenesisNote=Impairs interaction with PtdIns(3%2C4%2C5)P3 and PtdIns(3%2C4)P2. R->A%2CC;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12176338;Dbxref=PMID:12176338
P3174915582525MutagenesisNote=Impairs interaction with PtdIns(3%2C4%2C5)P3 and PtdIns(3%2C4)P2. R->A%2CC;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12176338;Dbxref=PMID:12176338
P3174915582525MutagenesisNote=Impairs interaction with PtdIns(3%2C4%2C5)P3 and PtdIns(3%2C4)P2. R->A%2CC;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12176338;Dbxref=PMID:12176338
P3174915582525MutagenesisNote=Impairs interaction with PtdIns(3%2C4%2C5)P3 and PtdIns(3%2C4)P2. R->A%2CC;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12176338;Dbxref=PMID:12176338
P3174915582525MutagenesisNote=Impairs interaction with PtdIns(3%2C4%2C5)P3 and PtdIns(3%2C4)P2. R->A%2CC;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12176338;Dbxref=PMID:12176338
P31749145189176176MutagenesisNote=Significant loss of interaction with TNK2. Loss of membrane localization. Significant reduction in phosphorylation on Ser-473. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20333297;Dbxref=PMID:20333297
P31749145189176176MutagenesisNote=Significant loss of interaction with TNK2. Loss of membrane localization. Significant reduction in phosphorylation on Ser-473. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20333297;Dbxref=PMID:20333297
P31749145189176176MutagenesisNote=Significant loss of interaction with TNK2. Loss of membrane localization. Significant reduction in phosphorylation on Ser-473. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20333297;Dbxref=PMID:20333297
P31749145189176176MutagenesisNote=Significant loss of interaction with TNK2. Loss of membrane localization. Significant reduction in phosphorylation on Ser-473. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20333297;Dbxref=PMID:20333297
P31749145189176176MutagenesisNote=Significant loss of interaction with TNK2. Loss of membrane localization. Significant reduction in phosphorylation on Ser-473. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20333297;Dbxref=PMID:20333297
P31749145189176176MutagenesisNote=Significant loss of interaction with TNK2. Loss of membrane localization. Significant reduction in phosphorylation on Ser-473. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20333297;Dbxref=PMID:20333297
P31749145189173174Sequence conflictNote=GR->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P31749145189173174Sequence conflictNote=GR->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P31749145189173174Sequence conflictNote=GR->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P31749145189173174Sequence conflictNote=GR->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P31749145189173174Sequence conflictNote=GR->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P31749145189173174Sequence conflictNote=GR->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P31749211234212212Sequence conflictNote=A->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
P31749211234212212Sequence conflictNote=A->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
P31749211234212212Sequence conflictNote=A->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
P31749211234212212Sequence conflictNote=A->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
P31749211234212212Sequence conflictNote=A->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
P31749211234212212Sequence conflictNote=A->R;Ontology_term=ECO:0000305;evidence=ECO:0000305
P31749234276246246Sequence conflictNote=S->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P31749234276246246Sequence conflictNote=S->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P31749234276246246Sequence conflictNote=S->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P31749234276246246Sequence conflictNote=S->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P31749234276246246Sequence conflictNote=S->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P31749234276246246Sequence conflictNote=S->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
P317491558615Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P317491558615Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P317491558615Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P317491558615Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P317491558615Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915581719Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915581719Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915581719Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915581719Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915581719Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915582230Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915582230Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915582230Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915582230Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915582230Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915583340Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915583340Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915583340Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915583340Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915583340Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915584548HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915584548HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915584548HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915584548HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915584548HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915585256Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915585256Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915585256Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915585256Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P3174915585256Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1UNQ
P31749145189147149HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189147149HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189147149HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189147149HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189147149HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189147149HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189150158Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189150158Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189150158Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189150158Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189150158Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189150158Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189160169Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189160169Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189160169Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189160169Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189160169Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189160169Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189170172TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189170172TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189170172TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189170172TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189170172TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189170172TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189175182Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189175182Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189175182Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189175182Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189175182Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189175182Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189183188HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189183188HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189183188HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189183188HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189183188HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749145189183188HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749211234213218Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749211234213218Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749211234213218Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749211234213218Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749211234213218Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749211234213218Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749211234220227Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749211234220227Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749211234220227Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749211234220227Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749211234220227Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749211234220227Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749234276235242HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749234276235242HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749234276235242HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749234276235242HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749234276235242HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749234276235242HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749234276247268HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749234276247268HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749234276247268HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749234276247268HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749234276247268HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1
P31749234276247268HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4GV1


Top


Expression


check buttonGene expression level across TCGA pancancer
all structure

check buttonGene expression level across GTEx pantissue
all structure

check buttonExpression level of gene isoforms across TCGA pancancer
all structure

check buttonExpression level of gene isoforms across GTEx pantissue
all structure

check buttonCancer(tissue) type-specific expression level of Translation factor using z-score distriution
all structure

check buttonDifferential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)
all structure
Cancer typeTranslation factorFCadj.pval
LUADAKT1-4.537144606963410.0301695351050489


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Expression Regulation


check buttonTranslation factor expression regulation through miRNA binding
Cancer typeGenemiRNATargetScan binding score (Context++ score percentile)CoefficientPvalue


check buttonTranslation factor expression regulation through methylation in the promoter of Translation factor
all structure
Cancer typeGenemethyl group bmethyl group aDEG pvalavg methyl in bavg methyl in aavg exp in bavg exp in a
PRADAKT1320.02178958161978930.6401280974695410.5712040093240090.2452183014426590.416271386295476
SARCAKT1320.01982081728251360.7032261974584550.5513125541125540.04978000912462730.367671752596152

check buttonTranslation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)
all structure
Cancer typeGenemethyl group bmethyl group aDEG pvalavg methyl in bavg methyl in aavg exp in bavg exp in a
KIRCAKT1320.02942425575636580.6447526208178440.5749572058823530.6570070729007830.836810281954068

check buttonTranslation factor expression regulation through copy number variation of Translation factor
all structure
Cancer typeGeneCoefficientPvalue
LGGAKT10.1678079580.007914402
PCPGAKT1-0.1567569530.012206197

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Associated Genes


check button Strongly correlated genes belong to cellular important gene groups with AKT1 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)
all structure
Cancer typeGene groupTranslation factorCorrelated geneCoefficientPvalue
CHOLEpifactorAKT1SETD30.8167248837.89E-12
KICHCell metabolism geneAKT1INPPL10.8243983581.02E-23
KICHCell metabolism geneAKT1PYGB0.830430672.48E-24
KICHIUPHARAKT1EGLN20.8025993381.12E-21
KICHIUPHARAKT1NR2F60.805085046.76E-22
KICHIUPHARAKT1GAK0.8092637792.84E-22
KICHIUPHARAKT1INPPL10.8243983581.02E-23
KICHKinaseAKT1GAK0.8092637792.84E-22
KICHTFAKT1NR2F60.805085046.76E-22
KICHTFAKT1ZNF6290.8252387298.41E-24
UVMCell metabolism geneAKT1PRKCSH0.8234364136.92E-21
UVMTFAKT1SOX100.8221786858.90E-21


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Protein structure


check button Protein 3D structure
Visit iCn3D.


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Protein-Protein Interaction


check button Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))
all structure

check buttonOverlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))
all structure
check button
* Edge colors based on TCGA cancer types.

check button* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))
all structure
Cancer typeTranslation factorInteracting protein coding geneFCadj.pval
LIHCAKT1HSP90AA1-1.871377396719020.0003817245773207
LIHCAKT1FOXO31.535511049414240.00126327311470459
THCAAKT1EP300-1.563081890396030.00135477973345976
KICHAKT1FOXO32.35523349940370.00308787822723389
LIHCAKT1MDM2-1.570823103330190.00323738381247511
PRADAKT1EP3001.280011207376240.00383473418852013
STADAKT1MDM2-1.993126504855590.0132303284481168
LUSCAKT1FOXO3-1.278814782200540.0174932185880974
HNSCAKT1NOS3-2.902323872730620.0265030336049676
ESCAAKT1HSP90AA1-2.954078329285750.0322265625
STADAKT1FOXO3-1.494437625963360.0375871751457453
PRADAKT1NOS3-2.752819686078260.0400134807765078
ESCAAKT1APPL1-1.627668936909150.0419921875
BRCAAKT1HSP90AA12.19782205770151.13731762084626e-08
STADAKT1NOS31.962285763265071.26352533698082e-05
LIHCAKT1PHLPP1-1.372499087950192.25731418060625e-05
KIRCAKT1PHLPP11.634124067645712.54891161547424e-12
STADAKT1HSP90AA1-1.657051254302853.51201742887497e-06
LUSCAKT1PIK3CA2.042202461730836.19161914824481e-08
BRCAAKT1RICTOR-1.236962486385897.64567674547321e-05
PRADAKT1MTOR2.457673762698948.16442831201447e-07
KIRCAKT1APPL1-2.762123941135649.05905681935088e-10


check button Protein-protein interactors with this translation factor (BIOGRID-3.4.160)
PPI interactors with AKT1
PLXNA1, AR, BRCA1, FANCA, PAK1, AKTIP, TRIB3, HSP90AA1, IRAK1, IMPDH2, BRAF, HSPB1, MAPKAPK2, MAPK14, TCL1A, MTCP1, KRT10, RAF1, SMAD2, SMAD3, SMAD4, SMAD7, RPS6KB1, TSC1, TSC2, MAPKAP1, BAD, MTOR, GSK3B, TERT, CARHSP1, PRKCQ, THEM4, CDKN1B, NR4A1, MAP3K11, MAP2K4, PRKCZ, TCL1B, HSP90AB1, GAB2, CHUK, PDPK1, ILK, MAPK8IP1, PKN2, MAP3K8, YWHAZ, ARFIP2, IRS1, NPM1, STUB1, MARK2, NF2, PLXNB1, PIAS1, PIAS2, USP8, HDAC3, IKBKG, MXD1, NCOR2, SMARCB1, ACTA1, SMARCC1, SMARCC2, MDM2, EZH2, FOXO1, HSPA4, NOTCH1, CDC37, IKBKB, EP300, SETDB1, CREBBP, GSK3A, DNMT1, SKP2, PA2G4, ERBB3, NEDD4, TRIM13, CTBP1, TTC3, ESR1, CALM1, NCOA4, APOH, ASXL1, BPGM, COMMD1, DNAJB1, PPL, PI4K2B, ZHX1, EEF1G, DCTN1, PPP2CA, ARRB2, Nedd4, PHLPP1, FKBP5, PPP3CA, PTEN, IQGAP1, WNK4, TERF2IP, PPP1CC, USP4, MUL1, TOPBP1, RICTOR, RNF11, RNF115, SH3RF1, PPP2R4, IBTK, VCP, LRRK2, NSF, HSPA8, CAMK2A, ENO2, CKB, GNB1, CLTC, HK1, ATP1A1, TUBB, YWHAG, YWHAE, ENO1, GAPDH, HSPA5, PEBP1, UCHL1, MDH1, LDHA, HBB, PPIA, ALDOA, EIF4A1, PSMB4, GDA, ATP6V0A2, SKI, VIM, DDX5, HSPA9, TPM4, TPM2, ACTB, TRHDE, PPP1CA, SNCA, PINK1, PFKFB1, NOS3, APP, PHB2, KAT2B, SIRT1, FOXO3, CTNNB1, PRKDC, CREB1, ZFP36L1, RPTOR, PREX1, SERTAD4, Rpl23, Sertad4, APPL1, MST1R, BCL10, AKT1, STK3, CLK2, CSK, ARRB1, IGSF8, CD81, RARA, STK4, CCDC88A, MAP3K5, DAB2IP, CYLD, TRAF6, BCL2L1, RGCC, TBC1D4, RQCD1, PPP2R1A, JADE1, PIK3CA, NFE2L2, XIAP, PDZK1, SIRT6, FOXO4, ITPR1, ITPR3, GRB10, ALYREF, YBX1, CSNK2A1, GATA2, METTL1, HIST2H2BE, MAPT, GATA1, CLIP3, PLEKHO1, Foxo1, FHL1, KAT6A, FAM110C, ACAP1, CDKN1C, SNAI1, DLC1, SFN, PLCG1, EGFR, MAPK8, MAPK9, PPP1CB, Cdkn1b, CDKN1A, IRF3, TBK1, PDE3A, AKT1S1, SLC9A3R1, TNK2, PIK3CB, RPE, AGR3, CASC3, EPSTI1, IL13RA2, IL24, MRC2, MTA3, OSGIN1, RASL10B, S100A14, SERPINB5, ST14, TFF1, THRSP, WHSC1L1, ACAT2, GET4, CCNI, CLASP2, FASN, GFAP, GRIN2A, PDHB, PICK1, PLP1, PRKCB, PSMC5, PTGDS, PTPN3, SNCB, SRR, SULT4A1, ZNF691, TCOF1, PPM1A, SRC, EIF4EBP1, TRIM15, PYGO2, TRAF4, KLHL3, LTB4R2, NGB, AHSA1, GABBR2, HIST1H2BB, RASD2, CHEK1, PIK3R1, NFKBIA, AGAP2, FGFR1, DUSP13, AKT3, AKT2, NR2F2, SRPK2, TEK, PTK2, SLC9A1, FANCI, VHL, EGLN1, FANCD2, USP1, Csnk1d, CEP57L1, CEP76, CTDSP2, NOL4, TRMT2B, UBE2S, BCL3, CCNF, KMT2D, ITGB3, RAC1, ARNT, CUL1, TMCC2, MTUS2, ZRANB1, PFKP, IGF1R, GJA1, KANK1, BAIAP2, BAIAP2L1, IWS1, MYH9, CD2AP, UCK2, WFS1, CAMK2D, FLII, PKD2, INTS3, CAPN1, CABLES1, ATRX, EIF2AK3, PKD1, SP1, SP3, HDAC6, TUBA1A, NTRK1, BLVRA, PDK1, SSH1, SYTL1, FBXO31, TBC1D7, LANCL2, TMEM126B, SIRPA, PTPN11, MATK, SUPT6H, CHFR, FUS, NCF2, FAF1, BECN1, PIP5K1C, BABAM1, C11orf30, RPS6KA1, ZDHHC18, ZDHHC23, AURKA, CD44, CDK4, CDK6, CDKN2B, CDKN2C, EPHA2, FGFR4, FZR1, GLIS2, LATS2, MAP2K3, MAP2K5, MYC, PDGFRA, RASSF1, STK11, ARAF, CBLC, CCND2, CCNE1, CDKN2A, ERBB2, HIF1A, KAT2A, KDELR2, MAP2K6, MSH2, NF1, SOX4, TEAD2, TNFRSF1A, TP53, SOX2, MESDC2, XAF1, DDIT4L, PLEKHA4, HSP90B1, SLC25A3, RCN2, UBA52, UBB, UBC, RPS27A, HSPA6, HSP90AB3P, HSPA1A, BAG2, RSL1D1, NOP56, CCT7, DSG1, CCT2, CCT4, CCT8, CCT3, CCT6A, TCP1, DSP, CCT5, ANXA2P2, ANXA2, nsp2, BEX1, BUB1, CDH1, CTNNA1, FBXW7, MLH3, NRAS, PMS2, TLR2, HNRNPH1, UBR5, GLI1, NQO1, PCK1, DDX58, RNF8, NLGN3, COX2, SOSTDC1, MAPK4, RNF14, UMPS, DNAJB6, METTL21B, SSC4D, PDE3B, ABHD15, GATSL3, BAP1, KDM4B, WEE1, FAM129A, PCGF2,


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Mutations


check button Clinically associated variants from ClinVar.
GeneChrPositionRefSeqVarSeqRefSeeqVarTypePathogenicDiseaseVarInfo
AKT1chr14105236681GCsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105236684CTsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105236685GAsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105236689CTsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105236690GAsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105236702GCsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105236705GAsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105236727CTsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6|Familial_cancer_of_breastSO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105236728GAsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105236731CTsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105236732GAsingle_nucleotide_variantBenignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105236741AGsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105236748AGsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6|not_specifiedSO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105236749TCsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105236767TCsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105237026CCTCTCMicrosatelliteBenignnot_providedSO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105237073GAsingle_nucleotide_variantLikely_benignCowden_syndrome_6|not_providedSO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105237084TCsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105237094GAsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105237104GTsingle_nucleotide_variantLikely_benignCowden_syndrome_6|not_providedSO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105237116CTsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105237125CAsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105237142TGsingle_nucleotide_variantPathogenicCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105237152CTsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105237155CTsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105237156GAsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105237167CTsingle_nucleotide_variantLikely_benignCowden_syndrome_6|not_providedSO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105237168TGsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105237184GAsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105237194TGsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105237380GAsingle_nucleotide_variantLikely_benignnot_providedSO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105237401AGsingle_nucleotide_variantBenignnot_providedSO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105238512GAsingle_nucleotide_variantLikely_benignnot_providedSO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105238591CCTGAGCDeletionBenignnot_providedSO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105238604CTsingle_nucleotide_variantBenignnot_providedSO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105238609GAsingle_nucleotide_variantLikely_benignnot_providedSO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105238636GCsingle_nucleotide_variantBenignnot_providedSO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105238670CTsingle_nucleotide_variantBenignnot_providedSO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105238695GAsingle_nucleotide_variantLikely_benignnot_providedSO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105238697CTsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105238698GAsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105238701CGsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001575|splice_donor_variantSO:0001575|splice_donor_variant
AKT1chr14105238710CTsingle_nucleotide_variantUncertain_significancenot_providedSO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105238711GAsingle_nucleotide_variantBenign/Likely_benignCowden_syndrome_6|not_specified|none_provided|not_providedSO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105238714CTsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105238720CGsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105238728CTsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105238729GAsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105238734CTsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105238735GAsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105238746GAsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105238764TCsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6|Familial_cancer_of_breastSO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105238767CTsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105238768GAsingle_nucleotide_variantLikely_benignCowden_syndrome_6|not_specifiedSO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105238771CAsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105238773CGsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105238774GAsingle_nucleotide_variantLikely_benignCowden_syndrome_6|not_providedSO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105238783GAsingle_nucleotide_variantBenign/Likely_benignCowden_syndrome_6|not_providedSO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105238786AGsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105238789CTsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105238795GCsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105238820GCsingle_nucleotide_variantBenignnot_providedSO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105238878GAsingle_nucleotide_variantLikely_benignnot_providedSO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105238954CTsingle_nucleotide_variantBenignnot_providedSO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105239008GAsingle_nucleotide_variantLikely_benignnot_providedSO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105239144CTsingle_nucleotide_variantLikely_benignnot_providedSO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105239146CGsingle_nucleotide_variantBenignnot_providedSO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105239192TCsingle_nucleotide_variantBenignnot_providedSO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105239205CTsingle_nucleotide_variantLikely_benignCowden_syndrome_6|not_providedSO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105239206GAsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105239206GTsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105239210CTsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105239211TGsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105239226GAsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105239228CTsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105239238CTsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105239241CTsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105239253GAsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105239257TCsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105239265GAsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105239268ATsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105239274CGsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105239274CTsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105239275GAsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105239275GTsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105239278CTsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105239279GAsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105239280CGsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105239280CTsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105239283GAsingle_nucleotide_variantLikely_benignCowden_syndrome_6|not_providedSO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105239288GAsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105239288GTsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105239290AGsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105239299AGsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105239304GAsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105239307GAsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105239334GAsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105239349GAsingle_nucleotide_variantLikely_benignCowden_syndrome_6|not_providedSO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105239355GAsingle_nucleotide_variantBenignCowden_syndrome_6|not_specified|not_providedSO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105239367GAsingle_nucleotide_variantBenign/Likely_benignCowden_syndrome_6|Familial_cancer_of_breast|not_specified|none_provided|not_providedSO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105239376CTsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105239379GAsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105239382CTsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105239404CTsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105239409GAsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105239427CTsingle_nucleotide_variantLikely_benignCowden_syndrome_6|not_providedSO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105239435CTsingle_nucleotide_variantBenignCowden_syndrome_6SO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105239436GAsingle_nucleotide_variantBenignCowden_syndrome_6SO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105239581CTsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105239585CAsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105239585CTsingle_nucleotide_variantConflicting_interpretations_of_pathogenicityCowden_syndrome_6|not_specifiedSO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105239591GTsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105239594GTsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105239618AGsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105239628AGsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105239629TCsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105239638CTsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105239639GAsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105239666GAsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105239669GAsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105239690GAsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105239720GAsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105239782GAsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105239784CACDeletionLikely_benignCowden_syndrome_6SO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105239786GCsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105239787CGsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105239787CTsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105239788GAsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105239798GAsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105239810CTsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105239813GAsingle_nucleotide_variantBenignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105239821CTsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105239822CTsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105239823GAsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105239824ACsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105239837CTsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105239850AGsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105239855ACsingle_nucleotide_variantLikely_benignnot_providedSO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105239857CTsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105239869GAsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105239870GCsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105239871GAsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105239873CAsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105239875GAsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105239882GAsingle_nucleotide_variantConflicting_interpretations_of_pathogenicityCowden_syndrome_6|not_providedSO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105239893GAsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105239894CTsingle_nucleotide_variantBenignCowden_syndrome_6|not_specified|not_providedSO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105239898CTsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105239899GAsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105239901GCsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105239915CAsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105239915CTsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105239921CTsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105239922GAsingle_nucleotide_variantLikely_benignCowden_syndrome_6|not_providedSO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105239924GAsingle_nucleotide_variantLikely_benignnot_providedSO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105240042CTsingle_nucleotide_variantLikely_benignnot_providedSO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105240111GAsingle_nucleotide_variantBenignnot_providedSO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105240216GAsingle_nucleotide_variantBenignnot_providedSO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105240255CTsingle_nucleotide_variantLikely_benignCowden_syndrome_6|not_providedSO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105240258GAsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105240259TCsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105240264GAsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105240267CTsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105240282GCsingle_nucleotide_variantLikely_benignCowden_syndrome_6|not_providedSO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105240286CTsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105240287GAsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105240290CTsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105240291GAsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105240298TGsingle_nucleotide_variantUncertain_significanceFamilial_cancer_of_breastSO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105240310TCsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105240316GCsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105240450CTsingle_nucleotide_variantBenignnot_providedSO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105240530TCsingle_nucleotide_variantBenignnot_providedSO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105241266CTsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105241268CAsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105241296GAsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105241302CTsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105241304GAsingle_nucleotide_variantBenignCowden_syndrome_6|not_specified|not_providedSO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105241309CTsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105241317GAsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105241338GAsingle_nucleotide_variantConflicting_interpretations_of_pathogenicityCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105241378CTsingle_nucleotide_variantBenignnot_providedSO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105241397ACsingle_nucleotide_variantUncertain_significanceFamilial_cancer_of_breastSO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105241399CTsingle_nucleotide_variantLikely_benignnot_specified|not_providedSO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105241404CTsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105241405GAsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105241408CAsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105241419CTsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105241422GAsingle_nucleotide_variantBenignCowden_syndrome_6|not_specified|not_providedSO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105241428TCsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105241435TCsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105241452GAsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105241455GAsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105241459CTsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105241460GAsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105241468GAsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105241485GAsingle_nucleotide_variantLikely_benignCowden_syndrome_6|not_providedSO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105241497GAsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105241523GAsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105241527CTsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105241536GAsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105241540AGsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105241542GAsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105241547AGsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105241548TCsingle_nucleotide_variantLikely_benignCowden_syndrome_6|not_providedSO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105241576GAsingle_nucleotide_variantBenignnot_providedSO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105241607GAsingle_nucleotide_variantBenignnot_providedSO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105241992GAsingle_nucleotide_variantBenignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105241993CTsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105241994GAsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105242009CGsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105242012GAsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105242018CTsingle_nucleotide_variantConflicting_interpretations_of_pathogenicityCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105242030CTsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105242037TCsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105242037TGsingle_nucleotide_variantLikely_benignnot_providedSO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105242047CGsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105242050GAsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105242059GAsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105242062CTsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105242067GAsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105242068TCsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105242072TCTCTMicrosatelliteUncertain_significanceCowden_syndrome_6SO:0001822|inframe_deletionSO:0001822|inframe_deletion
AKT1chr14105242075CTsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105242076CTsingle_nucleotide_variantLikely_benignCowden_syndrome_6|not_providedSO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105242099CTsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105242100GAsingle_nucleotide_variantLikely_benignCowden_syndrome_6|not_providedSO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105242109AGsingle_nucleotide_variantLikely_benignCowden_syndrome_6|not_providedSO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105242115GAsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105242121GAsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105242130CTsingle_nucleotide_variantLikely_benignCowden_syndrome_6|not_providedSO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105242139GAsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105242140CAsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105242140CAGGCMicrosatelliteLikely_benignCowden_syndrome_6|not_providedSO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105242144AGTCIndelUncertain_significanceCowden_syndrome_6SO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105242228TCsingle_nucleotide_variantBenignnot_providedSO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105242257CTsingle_nucleotide_variantLikely_benignnot_providedSO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105242374GAsingle_nucleotide_variantBenignnot_providedSO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105242400CCCCCCAGCAGGACTCCGCDeletionBenignnot_providedSO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105242404CCAGCAGGACTCCGCCCCCCCCAAGCAGGACTCCGCCTCDeletionBenignnot_providedSO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105242405CAGCAGGACTCCGCCCCCCCCAAGCAGGACTCCGCCTCCCACDeletionBenignnot_providedSO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105242409ACsingle_nucleotide_variantBenignnot_providedSO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105242417GGCDuplicationBenignnot_providedSO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105242457GAsingle_nucleotide_variantLikely_benignnot_providedSO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105242826CAsingle_nucleotide_variantBenignnot_providedSO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105242826CTsingle_nucleotide_variantBenignnot_providedSO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105242831CTsingle_nucleotide_variantBenignnot_providedSO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105242966TCsingle_nucleotide_variantBenignnot_providedSO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105242991CTsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105242992GAsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105243005GTsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105243016AGsingle_nucleotide_variantLikely_benignCowden_syndrome_6|not_providedSO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105243031GAsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105243046CTsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105243047TCsingle_nucleotide_variantLikely_pathogenicnot_providedSO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105243048GTsingle_nucleotide_variantLikely_pathogenicMelanomaSO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105243056CTsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105243058GCsingle_nucleotide_variantnot_providednot_specifiedSO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105243077CTsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105243082CAsingle_nucleotide_variantLikely_benignCowden_syndrome_6|not_providedSO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105243084GAsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105243088CTsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105243104CTsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105243110GCsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105243111CTsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105243112GAsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105243112GTsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105243115CTsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105243220GAsingle_nucleotide_variantBenignnot_providedSO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105243352GTsingle_nucleotide_variantLikely_benignnot_providedSO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105243368CTsingle_nucleotide_variantLikely_benignnot_providedSO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105243435GTsingle_nucleotide_variantBenignnot_providedSO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105246325TAsingle_nucleotide_variantBenignCowden_syndrome_6|not_providedSO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105246407GAsingle_nucleotide_variantBenignnot_specifiedSO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105246420CTsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105246426CTsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105246457CTsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105246458GAsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105246462GTsingle_nucleotide_variantConflicting_interpretations_of_pathogenicityCowden_syndrome_6|not_specifiedSO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105246474CTsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105246478CTsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105246480CTsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105246483CTsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105246493AGsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105246494TCsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105246499GTsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105246519GAsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105246527GAsingle_nucleotide_variantPathogenicCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105246532CTsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105246550TCCTIndelPathogenicProteus_syndromeSO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105246551CTsingle_nucleotide_variantUncertain_significanceHepatocellular_carcinoma|Transitional_cell_carcinoma_of_the_bladder|Breast_neoplasm|Malignant_melanoma_of_skin|Lung_adenocarcinoma|Small_cell_lung_carcinoma|Non-small_cell_lung_carcinoma|Squamous_cell_lung_carcinoma|Neoplasm_of_uterine_cervix|AdenocarcinoSO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105246555TACTDeletionUncertain_significanceCowden_syndrome_6SO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105246557CAsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105246557CTsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105246561CAsingle_nucleotide_variantLikely_benignnot_providedSO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105246562GAsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105246629GAsingle_nucleotide_variantBenignnot_providedSO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105246681GAsingle_nucleotide_variantBenignnot_providedSO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105246686GAsingle_nucleotide_variantBenignnot_providedSO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105246692TAsingle_nucleotide_variantBenignnot_providedSO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105246872AGsingle_nucleotide_variantLikely_benignnot_providedSO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105258892CTsingle_nucleotide_variantBenignnot_providedSO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105258893AGsingle_nucleotide_variantBenignnot_providedSO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105258925GAsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105258925GCsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001627|intron_variantSO:0001627|intron_variant
AKT1chr14105258938GTsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105258965TCsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105258971CTsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105258972GAsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105258974CTsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105258975GAsingle_nucleotide_variantLikely_benignCowden_syndrome_6SO:0001819|synonymous_variantSO:0001819|synonymous_variant
AKT1chr14105258977TCsingle_nucleotide_variantUncertain_significanceCowden_syndrome_6SO:0001583|missense_variantSO:0001583|missense_variant
AKT1chr14105259025GCsingle_nucleotide_variantLikely_benignnot_providedSO:0001623|5_prime_UTR_variantSO:0001623|5_prime_UTR_variant


check button nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.
all structure


check button SNVs and Indels
GeneCancer typeChromosomeStartEndRefSeeqMutSeqMutation typeAAchange# samples
AKT1BLCAchr14105246551105246551CTMissense_Mutationp.E17K76
AKT1BLCAchr14105246551105246551CTMissense_Mutation6
AKT1KIRCchr14105246482105246482CTMissense_Mutationp.E40K6
AKT1LUADchr14105239420105239420CAMissense_Mutationp.D323Y5
AKT1SKCMchr14105239822105239822CTSilentp.S266S4
AKT1BRCAchr14105246445105246445ACMissense_Mutationp.L52R4
AKT1UCECchr14105243045105243045AGMissense_Mutationp.W80R3
AKT1BLCAchr14105243078105243078GTSilent3
AKT1UCECchr14105242084105242084CGMissense_Mutationp.E114Q3
AKT1BRCAchr14105238714105238714CASilentp.V4163
AKT1HNSCchr14105246455105246455CTMissense_Mutationp.E49K3
AKT1LIHCchr14105240253105240253C-Frame_Shift_Delp.G233fs3
AKT1THCAchr14105242025105242025CGMissense_Mutationp.E133D3
AKT1ESCAchr14105242111105242111TCMissense_Mutationp.T105A3
AKT1ESCAchr14105246502105246502CTMissense_Mutationp.G33D3
AKT1SKCMchr14105239613105239613CTMissense_Mutationp.G311D2
AKT1STADchr14105238717105238717GASilent2
AKT1BLCAchr14105242100105242100GASilentp.D108D2
AKT1SKCMchr14105242064105242064GASilentp.F120F2
AKT1STADchr14105238717105238717GASilentp.H415H2
AKT1ESCAchr14105242111105242111TCMissense_Mutation2
AKT1STADchr14105239379105239379GASilentp.G336G2
AKT1SKCMchr14105241328105241328GAMissense_Mutationp.H194Y2
AKT1STADchr14105241992105241992GASilentp.R144R2
AKT1PAADchr14105258975105258975GASilent2
AKT1SKCMchr14105241329105241329GASilentp.A193A2
AKT1BLCAchr14105242100105242100GASilent2
AKT1ESCAchr14105246502105246502CTMissense_Mutation2
AKT1STADchr14105237106105237106TCMissense_Mutationp.I447V2
AKT1PAADchr14105242041105242041TCMissense_Mutationp.N128S2
AKT1UCECchr14105237116105237116CTSilentp.T4432
AKT1SKCMchr14105241278105241278GASilentp.L210L2
AKT1DLBCchr14105239894105239894CTSilentp.E242E2
AKT1PAADchr14105258975105258975GASilentp.S2S2
AKT1UCECchr14105239274105239274CTSilentp.T3712
AKT1HNSCchr14105241317105241317GASilentp.T197T2
AKT1LIHCchr14105237131105237131A-Frame_Shift_Delp.F438fs2
AKT1UCECchr14105239693105239693CTSilentp.K2842
AKT1CESCchr14105258937105258937CTMissense_Mutation2
AKT1LIHCchr14105239385105239385C-Frame_Shift_Delp.G334fs2
AKT1UCECchr14105243048105243048GTMissense_Mutationp.Q79K2
AKT1ESCAchr14105238734105238734CTMissense_Mutationp.G410S2
AKT1LIHCchr14105239591105239591G-Frame_Shift_Delp.P318fs2
AKT1SKCMchr14105241449105241449GASilentp.A177A2
AKT1UCECchr14105246470105246470CTMissense_Mutationp.D44N2
AKT1LIHCchr14105239617105239617A-Frame_Shift_Delp.C310fs2
AKT1UCECchr14105246525105246525GASilentp.R252
AKT1BLCAchr14105243078105243078GTSilentp.R69R2
AKT1THYMchr14105246482105246482CTMissense_Mutation2
AKT1COADchr14105242063105242063GAMissense_Mutationp.R121W1
AKT1LGGchr14105241307105241307CTMissense_Mutationp.V201I1
AKT1ESCAchr14105241542105241542GTSilentp.T1461
AKT1HNSCchr14105246455105246455CTMissense_Mutation1
AKT1THYMchr14105241465105241465GTMissense_Mutation1
AKT1COADchr14105243089105243089GAMissense_Mutationp.T65M1
AKT1LGGchr14105241307105241307CTMissense_Mutation1
AKT1BLCAchr14105239387105239387CAMissense_Mutation1
AKT1ESCAchr14105246426105246426CTSilentp.A581
AKT1UCECchr14105239693105239693CTSilentp.K284K1
AKT1BLCAchr14105242078105242078CTMissense_Mutationp.E116K1
AKT1HNSCchr14105238729105238729GASilent1
AKT1OVchr14104313103104313103CTSilentp.S1221
AKT1COADchr14105246435105246435GTMissense_Mutationp.F55L1
AKT1LIHCchr14105237128105237128AGSilent1
AKT1PAADchr14105242041105242041TCMissense_Mutation1
AKT1BLCAchr14105239648105239648CGSilentp.G299G1
AKT1HNSCchr14105238729105238729GASilentp.I411I1
AKT1COADchr14105246457105246457CTMissense_Mutationp.R48H1
AKT1LIHCchr14105239702105239702CATranslation_Start_Site1
AKT1ESCAchr14105236687105236687GTSilent1
AKT1HNSCchr14105239675105239675GASilentp.I290I1
AKT1COADchr14105241522105241522AGMissense_Mutationp.L153P1
AKT1LIHCchr14105246536105246536AGMissense_Mutationp.W22R1
AKT1BLCAchr14105242078105242078CTMissense_Mutation1
AKT1ESCAchr14105238734105238734CTMissense_Mutation1
AKT1STADchr14105238712105238712TCMissense_Mutationp.Y417C1
AKT1CESCchr14105259018105259018CGMissense_Mutation1
AKT1SKCMchr14105243006105243006GAMissense_Mutationp.P93S1
AKT1DLBCchr14105238783105238783GASilentp.G393G1
AKT1BLCAchr14105242030105242030CTMissense_Mutation1
AKT1ESCAchr14105246426105246426CTSilentp.A58A1
AKT1TGCTchr14105236681105236681GTSilent1
AKT1SARCchr14105246473105246473GTMissense_Mutation1
AKT1KICHchr14105241517105241517GASilentp.L155L1
AKT1SKCMchr14105239274105239274CTSilentp.T371T1
AKT1ESCAchr14105236687105236687GTSilentp.G4781
AKT1BLCAchr14105239648105239648CGSilent1
AKT1ESCAchr14105241542105241542GTSilentp.T146T1
AKT1THCAchr14105246445105246445ACMissense_Mutation1
AKT1SARCchr14105241278105241278GTSilent1
AKT1CESCchr14105258937105258937CTMissense_Mutationp.R15Q1
AKT1SKCMchr14105246461105246461GANonsense_Mutationp.Q47*1
AKT1BLCAchr14105239387105239387CAMissense_Mutationp.G334W1
AKT1GBMchr14105241276105241276GAMissense_Mutationp.T211_splice1
AKT1COADchr14105239666105239666GASilentp.F293F1
AKT1KIRPchr14105237141105237141GCMissense_Mutationp.T435S1
AKT1SKCMchr14105246552105246552CTSplice_Sitep.G16_splice1
AKT1GBMchr14105241276105241276GAMissense_Mutation1
AKT1LIHCchr14105242033105242033C-Frame_Shift_Delp.A131fs1
AKT1THCAchr14105242073105242075CTC-In_Frame_Delp.E117del1
AKT1SKCMchr14105246461105246461GANonsense_Mutationp.Q47X1
AKT1COADchr14105240285105240285GASilentp.R222R1
AKT1KIRPchr14105239223105239223GTSilent1
AKT1SKCMchr14105241281105241281GASilentp.F209F1
AKT1HNSCchr14105241317105241317GASilent1
AKT1LIHCchr14105243082105243082CTSilent1

check buttonCopy number variation (CNV) of AKT1
* Click on the image to open the original image in a new window.
all structure

check buttonFusion gene breakpoints (product of the structural variants (SVs)) across AKT1
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


check button Fusion genes with this translation factor from FusionGDB2.0.
FusionGDB2 IDDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
102890BLCATCGA-FD-A3SR-01AAKT1chr14105235689-ANKS1Achr634977682+
101628THYMTCGA-X7-A8DFAKT1chr14105258935-B2Mchr1545007621+
102276STADTCGA-CG-5724-01AAKT1chr14105258935-DEDD2chr1942719404-
93667STADTCGA-HU-A4GN-01AAKT1chr14105258935-ITPK1chr1493542964-
101776N/AEC558032AKT1chr14105236179-KIF19chr1772341925+
92109N/ADR005286AKT1chr14105243210-MCAMchr11119187811-
87227N/ABC063408AKT1chr14105258934-PPP3R1chr268406102-
95542N/ABF338675AKT1chr14105235686-RORAchr1561475729+
100989N/ADI185158AKT1chr14105235686-USP3chr1563874236-
89829N/ABG032239AKT1chr14105235686-VDAC1chr5133387399-
102160N/ADA556158HSPB6chr1936246433-AKT1chr14105239870-
102160STADTCGA-FP-8210-01APRSS23chr1186534635+AKT1chr14105237184-
102162PRADTCGA-G9-6354-01AZNF461chr1937147350-AKT1chr14105246553-


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Prognostic Analysis


check button Kaplan-Meier plots with logrank tests of overall survival (OS)
all structure
Cancer typeTranslation factorCoefficentHazard ratioWald test pvalLikelihool ratio pvalLogrank test pval# samples


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Translation factor and Gender


check button Differential gene expression between female and male. (Wilcoxon test, pval<0.05)
all structure
Cancer typeTranslation factorpvaladj.p
TGCTAKT10.004151431542720540.12
KIRPAKT10.006707820207667130.18
LIHCAKT10.008210688571858910.21
LGGAKT10.0328269130076610.82

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Translation factor and Age


check button Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)
all structure
Cancer typeTranslation factorpvaladj.p
OVAKT13.69107092743921e-050.0012
THYMAKT10.001061361007553930.034

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Related Drugs


check button Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)
UniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
P31749DB00171ATPSmall moleculeInvestigational|Nutraceutical
P31749DB01169Arsenic trioxideInducerSmall moleculeApproved|Investigational
P31749DB01863Inositol 1,3,4,5-TetrakisphosphateSmall moleculeExperimental
P31749DB05971ArchexinSmall moleculeInvestigational
P31749DB06486EnzastaurinSmall moleculeInvestigational
P31749DB06641PerifosineSmall moleculeInvestigational
P31749DB07584N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amineSmall moleculeExperimental
P31749DB075855-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridineSmall moleculeExperimental
P31749DB00171ATP
P31749DB01169Arsenic trioxideInducer
P31749DB01863Inositol 1,3,4,5-Tetrakisphosphate
P31749DB05971Archexin
P31749DB06486Enzastaurin
P31749DB06641Perifosine
P31749DB07584N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
P31749DB075855-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine

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Related Diseases


check button Diseases associated with this translation factor.
(DisGeNet 4.0)
Disease IDDisease Name# PubMedsDisease source
C0005586Bipolar Disorder5PSYGENET
C0011570Mental Depression5PSYGENET
C0011581Depressive disorder5PSYGENET
C0036341Schizophrenia5CTD_human;GENOMICS_ENGLAND
C0006142Malignant neoplasm of breast3CGI;CTD_human;GENOMICS_ENGLAND;UNIPROT
C0085261Proteus Syndrome3CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
C0242379Malignant neoplasm of lung3CTD_human
C1140680Malignant neoplasm of ovary3CGI;CTD_human;GENOMICS_ENGLAND
C0376358Malignant neoplasm of prostate2CTD_human
C0919267ovarian neoplasm2CGI;CTD_human
C0006868Cannabis Abuse1CTD_human
C0006870Cannabis Dependence1CTD_human
C0007114Malignant neoplasm of skin1CTD_human
C0007137Squamous cell carcinoma1CTD_human
C0009402Colorectal Carcinoma1CTD_human;GENOMICS_ENGLAND
C0014544Epilepsy1CTD_human
C0018553Hamartoma Syndrome, Multiple1ORPHANET
C0018614Hashish Abuse1CTD_human
C0023487Acute Promyelocytic Leukemia1CTD_human
C0024809Marijuana Abuse1CTD_human
C0025286Meningioma1CGI;CTD_human
C0028754Obesity1CTD_human
C0032580Adenomatous Polyposis Coli1CTD_human
C0033937Psychoses, Drug1CTD_human
C0033941Psychoses, Substance-Induced1CTD_human
C0079772T-Cell Lymphoma1CTD_human
C0086237Epilepsy, Cryptogenic1CTD_human
C0205834Meningiomas, Multiple1CTD_human
C0236804Amphetamine Addiction1CTD_human
C0236807Amphetamine Abuse1CTD_human
C0259785Malignant Meningioma1CTD_human
C0281784Benign Meningioma1CTD_human
C0282313Condition, Preneoplastic1CTD_human
C0334605Meningothelial meningioma1CTD_human
C0334606Fibrous Meningioma1CTD_human
C0334607Psammomatous Meningioma1CTD_human
C0334608Angiomatous Meningioma1CTD_human
C0334609Hemangioblastic Meningioma1CTD_human
C0334610Hemangiopericytic Meningioma1CTD_human
C0334611Transitional Meningioma1CTD_human
C0347515Spinal Meningioma1CTD_human
C0349604Intracranial Meningioma1CTD_human
C0428791Aortic valve calcification1CTD_human
C0431121Clear Cell Meningioma1CTD_human
C0457190Xanthomatous Meningioma1CTD_human
C0678222Breast Carcinoma1CGI;CTD_human
C0751111Awakening Epilepsy1CTD_human
C0751303Cerebral Convexity Meningioma1CTD_human
C0751304Parasagittal Meningioma1CTD_human
C1168401Squamous cell carcinoma of the head and neck1CTD_human
C1257931Mammary Neoplasms, Human1CTD_human
C1334261Intraorbital Meningioma1CTD_human
C1334271Intraventricular Meningioma1CTD_human
C1335107Olfactory Groove Meningioma1CTD_human
C1384406Secretory meningioma1CTD_human
C1384408Microcystic meningioma1CTD_human
C1527197Angioblastic Meningioma1CTD_human
C1565950Posterior Fossa Meningioma1CTD_human
C1565951Sphenoid Wing Meningioma1CTD_human
C1623038Cirrhosis1CTD_human
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