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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: AKT2 (NCBI Gene ID:208)

Gene Summary

Gene Summary

Gene Information	Gene Name: AKT2
	Gene ID: 208
	Gene Symbol	AKT2
	Gene ID	208
	Gene Name	AKT serine/threonine kinase 2
	Synonyms	HIHGHH\|PKBB\|PKBBETA\|PRKBB\|RAC-BETA
	Cytomap	19q13.2
	Type of Gene	protein-coding
	Description	RAC-beta serine/threonine-protein kinasePKB betaRAC-PK-betamurine thymoma viral (v-akt) homolog-2protein kinase Akt-2protein kinase B betaputative v-akt murine thymoma viral oncoprotein 2rac protein kinase betav-akt murine thymoma viral oncogene h
	Modification date	20200313
	UniProtAcc	P31751

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	AKT2	GO:0030335	positive regulation of cell migration	25428377

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
AKT2	(67.6 - 355.7]

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Translation Studies in PubMed

We searched PubMed using 'AKT2[title] AND translation [title] AND human.'

Gene	Title	PMID
AKT2	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000392038	40741169	40741257	Frame-shift
ENST00000392038	40741796	40742011	Frame-shift
ENST00000392038	40742163	40742292	In-frame
ENST00000392038	40744811	40744880	In-frame
ENST00000392038	40745951	40746017	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000392038	40742163	40742292	5317	1131	1259	481	277	320
ENST00000392038	40744811	40744880	5317	939	1007	481	213	236
ENST00000392038	40745951	40746017	5317	873	938	481	191	213

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
P31751	213	236	1	481	Chain	ID=PRO_0000085608;Note=RAC-beta serine/threonine-protein kinase
P31751	191	213	1	481	Chain	ID=PRO_0000085608;Note=RAC-beta serine/threonine-protein kinase
P31751	277	320	1	481	Chain	ID=PRO_0000085608;Note=RAC-beta serine/threonine-protein kinase
P31751	213	236	152	409	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P31751	191	213	152	409	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P31751	277	320	152	409	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P31751	213	236	230	232	Region	Note=Inhibitor binding
P31751	277	320	277	279	Region	Note=Inhibitor binding
P31751	277	320	292	293	Region	Note=Inhibitor binding
P31751	277	320	280	280	Metal binding	Note=Manganese;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:12434148;Dbxref=PMID:12434148
P31751	277	320	293	293	Metal binding	Note=Manganese;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:12434148;Dbxref=PMID:12434148
P31751	191	213	200	200	Binding site	Note=Inhibitor
P31751	213	236	232	232	Binding site	Note=Inhibitor%3B via amide nitrogen
P31751	213	236	236	236	Binding site	Note=Inhibitor
P31751	277	320	279	279	Binding site	Note=Inhibitor%3B via carbonyl oxygen
P31751	277	320	293	293	Binding site	Note=Inhibitor
P31751	277	320	294	294	Binding site	Note=Inhibitor%3B via amide nitrogen
P31751	277	320	309	309	Modified residue	Note=Phosphothreonine%3B by PDPK1;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:12434148,ECO:0000269\|PubMed:15890450,ECO:0000269\|PubMed:20059950,ECO:0000269\|PubMed:9512493;Dbxref=PMID:12434148,PMID:15890450,PMID:20059950,PMID:9512493
P31751	277	320	306	306	Glycosylation	Note=O-linked (GlcNAc) threonine;Ontology_term=ECO:0000250;evidence=ECO:0000250
P31751	277	320	313	313	Glycosylation	Note=O-linked (GlcNAc) threonine;Ontology_term=ECO:0000250;evidence=ECO:0000250
P31751	277	320	297	311	Disulfide bond	Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:12517337;Dbxref=PMID:12517337
P31751	277	320	278	320	Alternative sequence	ID=VSP_056930;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
P31751	191	213	208	208	Natural variant	ID=VAR_040357;Note=R->K;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs35817154,PMID:17344846
P31751	277	320	309	309	Mutagenesis	Note=Impairs interaction with TTC3%3B when associated with A-474. T->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:15890450,ECO:0000269\|PubMed:20059950;Dbxref=PMID:15890450,PMID:20059950
P31751	277	320	309	309	Mutagenesis	Note=Constitutively active%3B when associated with D-474. T->E;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:15890450,ECO:0000269\|PubMed:20059950;Dbxref=PMID:15890450,PMID:20059950
P31751	191	213	194	205	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1O6L
P31751	213	236	215	220	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1O6L
P31751	213	236	222	230	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1O6L
P31751	277	320	280	283	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1O6L
P31751	277	320	289	291	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1O6L
P31751	277	320	298	300	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2UW9
P31751	277	320	310	312	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2JDO
P31751	277	320	314	316	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1O6L
P31751	277	320	319	322	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1O6L

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
PRAD	AKT2	1.0445197324651	0.00056691577859022
HNSC	AKT2	-6.40672767813808	0.00122944192639807
CHOL	AKT2	-4.09728475517264	0.00390625
LIHC	AKT2	-1.28319262096228	7.56292418171002e-05

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type

Gene

Coefficient

Pvalue

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with AKT2 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
LAML	Cell metabolism gene	AKT2	ALG12	0.800599203	7.00E-40
LAML	IUPHAR	AKT2	SLC39A13	0.810668829	1.33E-41
LAML	TSG	AKT2	FZR1	0.809105722	2.49E-41
UVM	TSG	AKT2	FZR1	0.804691301	2.42E-19

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
LIHC	AKT2	FOXO3	1.53551104941424	0.00126327311470459
ESCA	AKT2	TSC2	-3.24919207627469	0.001953125
KICH	AKT2	FOXO3	2.3552334994037	0.00308787822723389
COAD	AKT2	GSK3B	-2.07473522700806	0.00355097651481629
CHOL	AKT2	RPTOR	-2.34317187916664	0.00390625
LUSC	AKT2	TSC2	1.12504498503233	0.00646935999315137
THCA	AKT2	GSK3B	-1.45870393768663	0.0101673324163456
LUSC	AKT2	FOXO3	-1.27881478220054	0.0174932185880974
STAD	AKT2	TSC2	-1.66130396745917	0.018431528005749
CHOL	AKT2	GSK3B	-1.34315292666112	0.01953125
LUAD	AKT2	AKT1	-4.53714460696341	0.0301695351050489
UCEC	AKT2	GSK3B	-2.59871693447551	0.03125
STAD	AKT2	FOXO3	-1.49443762596336	0.0375871751457453
LUSC	AKT2	TBC1D4	-2.8510108392347	0.0396404633591005
ESCA	AKT2	APPL1	-1.62766893690915	0.0419921875
PRAD	AKT2	TBC1D4	1.51442923028906	1.02277717736817e-05
LIHC	AKT2	PHLPP1	-1.37249908795019	2.25731418060625e-05
KIRC	AKT2	PHLPP1	1.63412406764571	2.54891161547424e-12
KIRC	AKT2	TBC1D4	-1.99607210915811	3.04491316881372e-13
KIRP	AKT2	TBC1D4	-1.28713379408832	3.06125730276108e-06
LIHC	AKT2	TSC2	-2.06124259504281	3.59406613648813e-06
BRCA	AKT2	TBC1D4	-2.47586798642027	4.55693616423519e-32
KICH	AKT2	TSC2	-5.67340295495929	6.36577606201172e-05
LIHC	AKT2	RPTOR	-4.36362270436135	6.64579404273587e-07
BRCA	AKT2	RICTOR	-1.23696248638589	7.64567674547321e-05
PRAD	AKT2	MTOR	2.45767376269894	8.16442831201447e-07
KIRC	AKT2	APPL1	-2.76212394113564	9.05905681935088e-10

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with AKT2

APPL1, SH3RF1, GSK3B, TCL1A, PRKDC, TCL1B, MTCP1, SETDB1, TTC3, ESR1, GRK5, SKI, VIM, FSHR, APP, HSP90AA1, PNPLA3, SNX27, APOA1, APOB, CCL14, SPRR2A, SORBS2, NAMPT, TMED2, POFUT1, ABCG8, STEAP4, POLR1B, EGFR, PRKCZ, CLIP3, PLEKHO1, SNAI1, HIST1H3A, CDKN1A, PSMD9, CDK3, CSK, EIF4EBP1, GGA1, PIK3CB, PIK3CD, RPE, TMEM17, AP4M1, RACGAP1, AKT1, UBE2O, NR2F2, TPM2, USP9Y, FAT3, UBB, NSMCE4A, VHL, EGLN1, PPP2CA, PDPK1, UCHL1, WDR26, GNB1, FKBP5, CUL1, PFKP, HMGCR, CDK12, PRKAB1, PARP1, GRM2, GHSR, CDK5, NTRK1, BLVRA, PIP5K1C, TRIB3, PICK1, MEOX2, SORBS3, REL, PLEKHA4, M, S, HNRNPH1, DNAJB13, C11orf52, COIL, GJA1, KRAS, LAMP1, LYN, RAB2A, RAB35, RCHY1, XAF1, KCNQ3,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
AKT2	chr19	40739513	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
AKT2	chr19	40739721	G	T	single_nucleotide_variant	Benign	not_provided	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
AKT2	chr19	40739826	G	A	single_nucleotide_variant	Uncertain_significance	Type_2_diabetes_mellitus\|Hypoglycemia,_neonatal,_simulating_foetopathia_diabetica	SO:0001583\|missense_variant	SO:0001583\|missense_variant
AKT2	chr19	40739865	G	A	single_nucleotide_variant	Likely_benign	Type_2_diabetes_mellitus\|Hypoglycemia,_neonatal,_simulating_foetopathia_diabetica	SO:0001627\|intron_variant	SO:0001627\|intron_variant
AKT2	chr19	40740955	G	A	single_nucleotide_variant	Uncertain_significance	Type_2_diabetes_mellitus\|Hypoglycemia,_neonatal,_simulating_foetopathia_diabetica	SO:0001583\|missense_variant	SO:0001583\|missense_variant
AKT2	chr19	40740986	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
AKT2	chr19	40741032	T	C	single_nucleotide_variant	Uncertain_significance	Type_2_diabetes_mellitus\|Hypoglycemia,_neonatal,_simulating_foetopathia_diabetica	SO:0001583\|missense_variant	SO:0001583\|missense_variant
AKT2	chr19	40741187	C	T	single_nucleotide_variant	Uncertain_significance	Inborn_genetic_diseases	SO:0001583\|missense_variant	SO:0001583\|missense_variant
AKT2	chr19	40741694	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
AKT2	chr19	40741860	C	T	single_nucleotide_variant	Likely_pathogenic	Non-small_cell_lung_carcinoma	SO:0001583\|missense_variant	SO:0001583\|missense_variant
AKT2	chr19	40741862	C	A	single_nucleotide_variant	Benign	Type_2_diabetes_mellitus\|Hypoglycemia,_neonatal,_simulating_foetopathia_diabetica\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
AKT2	chr19	40741862	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
AKT2	chr19	40741907	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
AKT2	chr19	40741930	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
AKT2	chr19	40741949	G	A	single_nucleotide_variant	Likely_benign	Type_2_diabetes_mellitus\|Hypoglycemia,_neonatal,_simulating_foetopathia_diabetica	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
AKT2	chr19	40742024	G	A	single_nucleotide_variant	Likely_benign	Type_2_diabetes_mellitus	SO:0001627\|intron_variant	SO:0001627\|intron_variant
AKT2	chr19	40742105	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
AKT2	chr19	40742161	C	T	single_nucleotide_variant	Likely_benign	Type_2_diabetes_mellitus\|Hypoglycemia,_neonatal,_simulating_foetopathia_diabetica\|not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
AKT2	chr19	40742164	C	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant
AKT2	chr19	40742179	C	T	single_nucleotide_variant	Benign/Likely_benign	Type_2_diabetes_mellitus\|Hypoglycemia,_neonatal,_simulating_foetopathia_diabetica\|not_specified\|not_provided	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant
AKT2	chr19	40742220	T	C	single_nucleotide_variant	Likely_pathogenic	Neoplasm_of_the_large_intestine	SO:0001583\|missense_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001627\|intron_variant
AKT2	chr19	40742263	G	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant
AKT2	chr19	40742320	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
AKT2	chr19	40743694	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
AKT2	chr19	40743866	T	C	single_nucleotide_variant	Likely_benign	Type_2_diabetes_mellitus\|Hypoglycemia,_neonatal,_simulating_foetopathia_diabetica	SO:0001627\|intron_variant	SO:0001627\|intron_variant
AKT2	chr19	40743886	C	T	single_nucleotide_variant	Pathogenic	Type_2_diabetes_mellitus	SO:0001583\|missense_variant	SO:0001583\|missense_variant
AKT2	chr19	40743950	G	A	single_nucleotide_variant	Uncertain_significance	Type_2_diabetes_mellitus\|Hypoglycemia,_neonatal,_simulating_foetopathia_diabetica	SO:0001583\|missense_variant	SO:0001583\|missense_variant
AKT2	chr19	40743996	C	G	single_nucleotide_variant	Likely_benign	Type_2_diabetes_mellitus\|Hypoglycemia,_neonatal,_simulating_foetopathia_diabetica	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
AKT2	chr19	40744007	G	A	single_nucleotide_variant	Likely_benign	Type_2_diabetes_mellitus\|Hypoglycemia,_neonatal,_simulating_foetopathia_diabetica	SO:0001627\|intron_variant	SO:0001627\|intron_variant
AKT2	chr19	40744160	T	TA	Duplication	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
AKT2	chr19	40744548	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
AKT2	chr19	40744697	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
AKT2	chr19	40744821	G	A	single_nucleotide_variant	Likely_benign	Type_2_diabetes_mellitus\|Hypoglycemia,_neonatal,_simulating_foetopathia_diabetica	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
AKT2	chr19	40744854	G	A	single_nucleotide_variant	Benign	Type_2_diabetes_mellitus\|Hypoglycemia,_neonatal,_simulating_foetopathia_diabetica	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
AKT2	chr19	40744863	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
AKT2	chr19	40745968	C	T	single_nucleotide_variant	Uncertain_significance	Type_2_diabetes_mellitus\|Hypoglycemia,_neonatal,_simulating_foetopathia_diabetica	SO:0001583\|missense_variant	SO:0001583\|missense_variant
AKT2	chr19	40747533	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
AKT2	chr19	40747717	T	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
AKT2	chr19	40747820	C	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
AKT2	chr19	40747836	G	A	single_nucleotide_variant	Benign/Likely_benign	Type_2_diabetes_mellitus\|Hypoglycemia,_neonatal,_simulating_foetopathia_diabetica\|not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
AKT2	chr19	40747837	G	A	single_nucleotide_variant	Likely_benign	Type_2_diabetes_mellitus\|Hypoglycemia,_neonatal,_simulating_foetopathia_diabetica\|not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
AKT2	chr19	40747868	G	A	single_nucleotide_variant	Uncertain_significance	Type_2_diabetes_mellitus\|Hypoglycemia,_neonatal,_simulating_foetopathia_diabetica	SO:0001583\|missense_variant	SO:0001583\|missense_variant
AKT2	chr19	40747902	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
AKT2	chr19	40747984	G	A	single_nucleotide_variant	Likely_benign	Type_2_diabetes_mellitus\|Hypoglycemia,_neonatal,_simulating_foetopathia_diabetica\|not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
AKT2	chr19	40748483	A	C	single_nucleotide_variant	Likely_benign	Type_2_diabetes_mellitus\|Hypoglycemia,_neonatal,_simulating_foetopathia_diabetica\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
AKT2	chr19	40748486	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
AKT2	chr19	40748513	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
AKT2	chr19	40748535	C	G	single_nucleotide_variant	Uncertain_significance	Type_2_diabetes_mellitus\|Hypoglycemia,_neonatal,_simulating_foetopathia_diabetica	SO:0001583\|missense_variant	SO:0001583\|missense_variant
AKT2	chr19	40748564	G	A	single_nucleotide_variant	Likely_benign	Type_2_diabetes_mellitus\|Hypoglycemia,_neonatal,_simulating_foetopathia_diabetica	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
AKT2	chr19	40748602	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
AKT2	chr19	40748639	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
AKT2	chr19	40748743	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
AKT2	chr19	40760745	GA	G	Deletion	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
AKT2	chr19	40761070	G	A	single_nucleotide_variant	Likely_benign	Type_2_diabetes_mellitus\|Hypoglycemia,_neonatal,_simulating_foetopathia_diabetica	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
AKT2	chr19	40761070	G	C	single_nucleotide_variant	Uncertain_significance	Type_2_diabetes_mellitus\|Hypoglycemia,_neonatal,_simulating_foetopathia_diabetica	SO:0001583\|missense_variant	SO:0001583\|missense_variant
AKT2	chr19	40761140	T	C	single_nucleotide_variant	Likely_benign	Type_2_diabetes_mellitus\|Hypoglycemia,_neonatal,_simulating_foetopathia_diabetica	SO:0001583\|missense_variant	SO:0001583\|missense_variant
AKT2	chr19	40761144	G	C	single_nucleotide_variant	Uncertain_significance	Type_2_diabetes_mellitus\|Hypoglycemia,_neonatal,_simulating_foetopathia_diabetica	SO:0001583\|missense_variant	SO:0001583\|missense_variant
AKT2	chr19	40761148	C	T	single_nucleotide_variant	Benign	Type_2_diabetes_mellitus\|Hypoglycemia,_neonatal,_simulating_foetopathia_diabetica\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
AKT2	chr19	40761212	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
AKT2	chr19	40761345	A	AGT	Microsatellite	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
AKT2	chr19	40762872	C	T	single_nucleotide_variant	Uncertain_significance	Type_2_diabetes_mellitus\|Hypoglycemia,_neonatal,_simulating_foetopathia_diabetica	SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant	SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant
AKT2	chr19	40762876	G	A	single_nucleotide_variant	Likely_benign	Type_2_diabetes_mellitus\|Hypoglycemia,_neonatal,_simulating_foetopathia_diabetica	SO:0001819\|synonymous_variant,SO:0001623\|5_prime_UTR_variant	SO:0001819\|synonymous_variant,SO:0001623\|5_prime_UTR_variant
AKT2	chr19	40762915	G	A	single_nucleotide_variant	Benign	Type_2_diabetes_mellitus\|Hypoglycemia,_neonatal,_simulating_foetopathia_diabetica\|not_specified\|not_provided	SO:0001819\|synonymous_variant,SO:0001623\|5_prime_UTR_variant	SO:0001819\|synonymous_variant,SO:0001623\|5_prime_UTR_variant
AKT2	chr19	40762959	C	T	single_nucleotide_variant	Pathogenic	Hypoglycemia,_neonatal,_simulating_foetopathia_diabetica	SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant	SO:0001583\|missense_variant,SO:0001623\|5_prime_UTR_variant
AKT2	chr19	40770860	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
AKT2	chr19	40770982	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
AKT2	chr19	40771131	C	T	single_nucleotide_variant	Uncertain_significance	Type_2_diabetes_mellitus	SO:0001583\|missense_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001627\|intron_variant
AKT2	chr19	40771136	G	A	single_nucleotide_variant	Likely_benign	Type_2_diabetes_mellitus\|Hypoglycemia,_neonatal,_simulating_foetopathia_diabetica	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
AKT2	KIRC	chr19	40742001	40742001	T	C	Missense_Mutation	p.D324G	5
AKT2	STAD	chr19	40747910	40747910	G	A	Missense_Mutation	p.R170W	4
AKT2	LIHC	chr19	40746009	40746009	G	T	Silent	p.V194V	4
AKT2	STAD	chr19	40743902	40743902	G	A	Missense_Mutation	p.R269W	3
AKT2	BRCA	chr19	40741906	40741906	C	T	Missense_Mutation	p.E356K	3
AKT2	KIRP	chr19	40741033	40741033	G	C	Missense_Mutation	p.Q429E	3
AKT2	ESCA	chr19	40742171	40742171	G	A	Missense_Mutation	p.A318V	3
AKT2	HNSC	chr19	40739814	40739814	G	A	Missense_Mutation	p.P471S	3
AKT2	LIHC	chr19	40742001	40742001	T	C	Missense_Mutation		3
AKT2	LIHC	chr19	40746009	40746009	G	T	Silent		2
AKT2	UCEC	chr19	40762851	40762851	T	G	Missense_Mutation	p.N53H	2
AKT2	BRCA	chr19	40761100	40761100	G	A	Silent	p.I84	2
AKT2	SKCM	chr19	40747936	40747936	C	A	Missense_Mutation	p.G161V	2
AKT2	STAD	chr19	40745960	40745960	A	G	Missense_Mutation	p.F211L	2
AKT2	SKCM	chr19	40743886	40743886	C	G	Missense_Mutation	p.R274P	2
AKT2	SARC	chr19	40740957	40740957	T	C	Missense_Mutation		2
AKT2	THCA	chr19	40762959	40762959	C	T	Missense_Mutation	p.E17K	2
AKT2	LUAD	chr19	40745995	40745995	G	C	Missense_Mutation	p.T199S	2
AKT2	CESC	chr19	40762875	40762875	G	C	Missense_Mutation		2
AKT2	STAD	chr19	40762934	40762934	C	T	Missense_Mutation	p.R25Q	2
AKT2	HNSC	chr19	40741920	40741920	T	C	Missense_Mutation	p.Y351C	2
AKT2	SARC	chr19	40740986	40740986	G	A	Silent		2
AKT2	STAD	chr19	40747850	40747850	C	T	Missense_Mutation	p.A190T	2
AKT2	LIHC	chr19	40740960	40740960	G	-	Frame_Shift_Del	p.P453fs	2
AKT2	HNSC	chr19	40740869	40740869	C	A	Missense_Mutation	p.E421D	2
AKT2	UCEC	chr19	40741869	40741869	C	T	Missense_Mutation	p.R368H	2
AKT2	LUAD	chr19	40761077	40761077	G	A	Missense_Mutation	p.S92F	2
AKT2	CESC	chr19	40741040	40741040	G	C	Missense_Mutation		2
AKT2	LIHC	chr19	40748525	40748525	G	-	Frame_Shift_Del	p.P119fs	2
AKT2	UCEC	chr19	40741942	40741942	T	C	Missense_Mutation	p.M344V	2
AKT2	LUAD	chr19	40748459	40748459	G	A	Silent	p.S141S	2
AKT2	STAD	chr19	40741932	40741932	C	T	Missense_Mutation	p.R347H	2
AKT2	LIHC	chr19	40762855	40762855	G	-	Frame_Shift_Del	p.P51fs	2
AKT2	HNSC	chr19	40741810	40741810	C	T	Missense_Mutation	p.D388N	2
AKT2	SKCM	chr19	40740978	40740978	G	A	Missense_Mutation	p.S447F	2
AKT2	UCEC	chr19	40748452	40748452	G	A	Missense_Mutation	p.R144W	2
AKT2	STAD	chr19	40747883	40747883	C	T	Missense_Mutation	p.A179T	2
AKT2	ESCA	chr19	40761157	40761157	G	A	Silent		2
AKT2	HNSC	chr19	40762855	40762855	G	A	Silent	p.P51P	2
AKT2	UCEC	chr19	40748465	40748465	C	T	Silent	p.A139	2
AKT2	ESCA	chr19	40742171	40742171	G	A	Missense_Mutation		2
AKT2	STAD	chr19	40743902	40743902	G	A	Missense_Mutation		2
AKT2	STAD	chr19	40762839	40762839	C	T	Missense_Mutation	p.V57I	2
AKT2	UCEC	chr19	40748486	40748486	C	T	Silent	p.T132	2
AKT2	BRCA	chr19	40741973	40741973	C	T	Nonsense_Mutation	p.W333*	2
AKT2	KIRC	chr19	40742002	40742002	C	G	Missense_Mutation	p.D324H	2
AKT2	SKCM	chr19	40741909	40741909	G	A	Missense_Mutation	p.H355Y	2
AKT2	STAD	chr19	40745960	40745960	A	G	Missense_Mutation		2
AKT2	LIHC	chr19	40741863	40741863	G	T	Missense_Mutation		2
AKT2	UCEC	chr19	40761146	40761146	C	T	Missense_Mutation	p.R69Q	2
AKT2	BRCA	chr19	40742257	40742257	G	C	Missense_Mutation	p.I289M	2
AKT2	SKCM	chr19	40747872	40747872	G	A	Silent	p.I182I	2
AKT2	LUAD	chr19	40745964	40745964	G	A	Silent	p.H209H	1
AKT2	COAD	chr19	40761148	40761148	C	T	Silent	p.P68P	1
AKT2	HNSC	chr19	40739814	40739814	G	A	Missense_Mutation		1
AKT2	SARC	chr19	40739826	40739826	G	T	Silent		1
AKT2	THCA	chr19	40762959	40762959	C	T	Missense_Mutation		1
AKT2	KIRP	chr19	40743897	40743897	G	T	Missense_Mutation	p.D270E	1
AKT2	LIHC	chr19	40741974	40741974	C	T	Nonsense_Mutation		1
AKT2	LUAD	chr19	40745969	40745969	T	C	Missense_Mutation	p.R208G	1
AKT2	COAD	chr19	40739823	40739823	T	A	Missense_Mutation	p.T468S	1
AKT2	LIHC	chr19	40743931	40743931	A	G	Missense_Mutation	p.I259T	1
AKT2	BLCA	chr19	40739846	40739846	C	T	Missense_Mutation		1
AKT2	HNSC	chr19	40762855	40762855	G	A	Silent		1
AKT2	SARC	chr19	40762923	40762923	G	T	Missense_Mutation		1
AKT2	THCA	chr19	40741814	40741814	C	A	Missense_Mutation		1
AKT2	LIHC	chr19	40741948	40741948	C	A	Nonsense_Mutation		1
AKT2	LUSC	chr19	40761067	40761067	C	T	Silent	p.E95E	1
AKT2	DLBC	chr19	40741861	40741861	G	A	Missense_Mutation	p.R371C	1
AKT2	BLCA	chr19	40742005	40742005	C	T	Missense_Mutation		1
AKT2	HNSC	chr19	40741810	40741810	C	T	Missense_Mutation		1
AKT2	SKCM	chr19	40739804	40739804	G	A	Missense_Mutation	p.S474F	1
AKT2	KIRP	chr19	40743950	40743950	G	A	Missense_Mutation	p.R253W	1
AKT2	LUSC	chr19	40747908	40747908	C	A	Silent	p.R170R	1
AKT2	ESCA	chr19	40740796	40740796	G	A	Missense_Mutation	p.P446S	1
AKT2	LIHC	chr19	40761108	40761108	T	C	Missense_Mutation	p.T82A	1
AKT2	BLCA	chr19	40741238	40741238	C	T	Missense_Mutation		1
AKT2	THCA	chr19	40741814	40741814	C	A	Missense_Mutation	p.K386N	1
AKT2	LUAD	chr19	40745982	40745982	G	A	Silent	p.V203V	1
AKT2	SKCM	chr19	40747871	40747871	G	A	Silent	p.L183L	1
AKT2	CESC	chr19	40762918	40762918	C	G	Missense_Mutation		1
AKT2	KIRP	chr19	40741033	40741033	G	C	Missense_Mutation		1
AKT2	PAAD	chr19	40743876	40743876	C	A	Missense_Mutation		1
AKT2	BLCA	chr19	40740861	40740861	C	T	Missense_Mutation	p.R424Q	1
AKT2	SARC	chr19	40740986	40740986	G	A	Silent	p.T444T	1
AKT2	SKCM	chr19	40741983	40741983	G	A	Missense_Mutation	p.A330V	1
AKT2	LGG	chr19	40744860	40744860	C	T	Silent	p.Q220Q	1
AKT2	PAAD	chr19	40743876	40743876	C	A	Splice_Site	p.K277_splice	1
AKT2	STAD	chr19	40741022	40741022	G	A	Silent	p.S432S	1
AKT2	ESCA	chr19	40746174	40746174	G	A	RNA	NULL	1
AKT2	BLCA	chr19	40739846	40739846	C	T	Missense_Mutation	p.G460D	1
AKT2	SARC	chr19	40740957	40740957	T	C	Missense_Mutation	p.D454G	1
AKT2	SKCM	chr19	40762841	40762841	G	A	Missense_Mutation	p.S56F	1
AKT2	CESC	chr19	40771139	40771139	G	A	Silent	p.L12L	1
AKT2	LGG	chr19	40744860	40744860	C	T	Silent		1
AKT2	PAAD	chr19	40762881	40762881	C	T	Missense_Mutation	p.E43K	1
AKT2	ESCA	chr19	40761157	40761157	G	A	Nonsense_Mutation	p.R7*	1
AKT2	BLCA	chr19	40747875	40747875	C	A	Missense_Mutation	p.K181N	1
AKT2	LUAD	chr19	40741249	40741249	C	A	Missense_Mutation	p.G395V	1
AKT2	SKCM	chr19	40762863	40762863	G	A	Silent	p.L49L	1
AKT2	CESC	chr19	40741040	40741040	G	C	Missense_Mutation	p.F426L	1
AKT2	LIHC	chr19	40761066	40761066	T	C	Missense_Mutation		1
AKT2	PAAD	chr19	40743876	40743876	C	A	Splice_Site	p.K277N	1
AKT2	LIHC	chr19	40762874	40762874	G	-	Frame_Shift_Del	p.P45fs	1
AKT2	BLCA	chr19	40742005	40742005	C	T	Missense_Mutation	p.E323K	1
AKT2	SKCM	chr19	40741983	40741983	G	A	Missense_Mutation	p.A268V	1
AKT2	LUAD	chr19	40740980	40740980	C	A	Missense_Mutation	p.Q446H	1
AKT2	SKCM	chr19	40741920	40741920	T	-	Frame_Shift_Del	p.Y351fs	1
AKT2	CESC	chr19	40771139	40771139	G	A	Silent	p.L12	1
AKT2	PRAD	chr19	40762906	40762906	G	T	Silent	p.S34S	1
AKT2	STAD	chr19	40762855	40762855	G	-	Frame_Shift_Del	p.L52X	1
AKT2	LIHC	chr19	40741984	40741984	C	-	Frame_Shift_Del	p.A330fs	1
AKT2	BLCA	chr19	40741238	40741238	C	T	Missense_Mutation	p.D399N	1
AKT2	HNSC	chr19	40741253	40741254	-	A	Frame_Shift_Ins	p.W394fs	1
AKT2	SKCM	chr19	40741920	40741920	T	-	Frame_Shift_Del	p.Y351X	1
AKT2	LUAD	chr19	40739787	40739787	G	A	Missense_Mutation	p.R480C	1
AKT2	COAD	chr19	40743924	40743924	C	T	Silent	p.S261S	1
AKT2	LIHC	chr19	40761108	40761108	T	C	Missense_Mutation		1
AKT2	ESCA	chr19	40761157	40761157	G	A	Silent	p.T65T	1
AKT2	LIHC	chr19	40748501	40748501	G	-	Frame_Shift_Del	p.P127fs	1
AKT2	PRAD	chr19	40745988	40745988	G	A	Silent	p.S201S	1
AKT2	LIHC	chr19	40744816	40744816	C	-	Frame_Shift_Del	p.G235fs	1
AKT2	LUAD	chr19	40741976	40741976	G	T	Missense_Mutation	p.D332E	1
AKT2	COAD	chr19	40744851	40744851	G	A	Silent	p.D223D	1
AKT2	HNSC	chr19	40741920	40741920	T	C	Missense_Mutation		1
AKT2	READ	chr19	40746008	40746008	C	T	Missense_Mutation	p.A195T	1
AKT2	STAD	chr19	40762855	40762855	G	-	Frame_Shift_Del	p.L52fs	1
AKT2	LIHC	chr19	40748449	40748449	C	-	Frame_Shift_Del	p.A145fs	1

Copy number variation (CNV) of AKT2
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across AKT2
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
101647	N/A	BF739868	AKT2	chr19	40740983	-	AKT2	chr19	40791210	-
101314	GBM	TCGA-19-A6J5-01A	AKT2	chr19	40791088	-	BTBD2	chr19	1997462	-
103334	OV	TCGA-25-1635-01A	AKT2	chr19	40791088	-	CXCL11	chr4	76957217	-
99324	N/A	BF996610	AKT2	chr19	40771152	-	DNAJC3	chr13	96445542	-
102715	SKCM	TCGA-EE-A2GL-06A	AKT2	chr19	40736224	-	ELK3	chr12	96588323	+
69728	LUSC	TCGA-85-A510	AKT2	chr19	40791087	-	MAP3K10	chr19	40711817	+
69728	LUSC	TCGA-85-A510	AKT2	chr19	40791087	-	MAP3K10	chr19	40715009	+
69728	LUSC	TCGA-85-A510	AKT2	chr19	40791088	-	MAP3K10	chr19	40711818	+
69728	LUSC	TCGA-85-A510	AKT2	chr19	40791088	-	MAP3K10	chr19	40715010	+
69728	LUSC	TCGA-85-A510-01A	AKT2	chr19	40789258	-	MAP3K10	chr19	40711535	+
87210	PAAD	TCGA-RB-AA9M-01A	AKT2	chr19	40741797	-	NSMAF	chr8	59508218	-
3489	STAD	TCGA-RD-A8MW-01A	AKT2	chr19	40740851	-	PIM1	chr6	37137992	+
95815	SARC	TCGA-K1-A6RU-01A	AKT2	chr19	40762833	-	SMIM17	chr19	57156936	+
65929	LGG	TCGA-E1-A7Z2	AKT2	chr19	40771129	-	SRRM5	chr19	44101249	+
65929	LGG	TCGA-E1-A7Z2-01A	AKT2	chr19	40771129	-	SRRM5	chr19	44101246	+
95758	N/A	BI021056	AKT2	chr19	40739823	-	U2AF2	chr19	56170673	+
102220	LGG	TCGA-P5-A5EU-01A	AKT2	chr19	40791088	-	UPF1	chr19	18956789	+
101031	BRCA	TCGA-D8-A1XZ-01A	AKT2	chr19	40761065	-	YIF1B	chr19	38800283	-
101031	UCEC	TCGA-BG-A3PP-01A	AKT2	chr19	40791088	-	YIF1B	chr19	38800283	-
65932	LGG	TCGA-E1-A7Z2	AKT2	chr19	40771129	-	ZNF576	chr19	44101249	+
65932	LGG	TCGA-E1-A7Z2-01A	AKT2	chr19	40771129	-	ZNF576	chr19	44101246	+
101647	.	.	BCAM	chr19	45322838	+	AKT2	chr19	45322838	-
101647	OV	TCGA-25-2404-01A	BCAT1	chr12	25047209	-	AKT2	chr19	40771258	-
101647	N/A	BF950673	CES4A	chr16	67043557	+	AKT2	chr19	40773373	+
101647	ESCA	TCGA-VR-A8EO	MRPL35	chr2	86437736	+	AKT2	chr19	40761176	-
101647	STAD	TCGA-RD-A8MW-01A	NFYA	chr6	41040823	+	AKT2	chr19	40739858	-
101647	N/A	DA657610	RPS8	chr1	45244127	+	AKT2	chr19	40761110	-
101647	GBM	TCGA-19-A6J5-01A	SPTBN4	chr19	40973212	+	AKT2	chr19	40771258	-
101647	N/A	DA742787	ZIC1	chr3	147132326	-	AKT2	chr19	40771260	-
101650	CESC	TCGA-IR-A3LH-01A	ZNF226	chr19	44669960	+	AKT2	chr19	40748594	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LIHC	AKT2	0.0495342163124928	1
KIRC	AKT2	2.98593521125964e-05	0.00084

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LIHC	AKT2	0.0134648569657938	0.43
STAD	AKT2	0.00306993937948348	0.1
PRAD	AKT2	0.0343596510939267	1

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
P31751	DB07812	N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide		Small molecule	Experimental
P31751	DB07859	4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE		Small molecule	Experimental
P31751	DB07947	ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE		Small molecule	Experimental
P31751	DB08073	(2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE		Small molecule	Experimental
P31751	DB07812	N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide
P31751	DB07859	4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE
P31751	DB07947	ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE
P31751	DB08073	(2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C3278384	HYPOINSULINEMIC HYPOGLYCEMIA WITH HEMIHYPERTROPHY	5	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
C0011860	Diabetes Mellitus, Non-Insulin-Dependent	4	CTD_human;GENOMICS_ENGLAND;UNIPROT
C0005586	Bipolar Disorder	1	PSYGENET
C0006142	Malignant neoplasm of breast	1	CGI;CTD_human
C0271694	Familial partial lipodystrophy	1	CTD_human
C0678222	Breast Carcinoma	1	CGI;CTD_human
C1257931	Mammary Neoplasms, Human	1	CTD_human
C1720859	Familial Partial Lipodystrophy, Type 1	1	CTD_human
C1720860	Familial Partial Lipodystrophy, Type 2	1	CTD_human
C1720861	Familial Partial Lipodystrophy, Type 3	1	CTD_human
C2931822	Nasopharyngeal carcinoma	1	CTD_human
C4316789	Partial lipodystrophy	1	GENOMICS_ENGLAND
C4704874	Mammary Carcinoma, Human	1	CTD_human