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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: ETF1 (NCBI Gene ID:2107)

Gene Summary

Gene Summary

Gene Information	Gene Name: ETF1
	Gene ID: 2107
	Gene Symbol	ETF1
	Gene ID	2107
	Gene Name	eukaryotic translation termination factor 1
	Synonyms	D5S1995\|ERF\|ERF1\|RF1\|SUP45L1\|TB3-1
	Cytomap	5q31.2
	Type of Gene	protein-coding
	Description	eukaryotic peptide chain release factor subunit 1polypeptide chain release factor 1protein Cl1sup45 (yeast omnipotent suppressor 45) homolog-like 1
	Modification date	20200329
	UniProtAcc	P62495

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0006415	Translational termination
GO:0008135	Translation factor activity, RNA binding
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ETF1	GO:0006415	translational termination	7990965
Hgene	ETF1	GO:0006479	protein methylation	18539146

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
ETF1	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'ETF1[title] AND translation [title] AND human.'

Gene	Title	PMID
ETF1	Eukaryotic translation termination factor gene (ETF1/eRF1) maps at D5S500 in a commonly deleted region of chromosome 5q31 in malignant myeloid diseases	10773672

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000360541	137844357	137844505	Frame-shift
ENST00000360541	137846253	137846318	Frame-shift
ENST00000360541	137846733	137846889	In-frame
ENST00000360541	137848452	137848643	Frame-shift
ENST00000360541	137849256	137849395	Frame-shift
ENST00000360541	137853249	137853389	Frame-shift
ENST00000360541	137878521	137878625	3UTR-3CDS

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000360541	137846733	137846889	3759	1085	1240	437	287	339

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
P62495	287	339	2	437	Chain	ID=PRO_0000143138;Note=Eukaryotic peptide chain release factor subunit 1
P62495	287	339	278	295	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1DT9
P62495	287	339	296	298	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1DT9
P62495	287	339	301	304	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1DT9
P62495	287	339	305	313	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1DT9
P62495	287	339	318	324	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1DT9
P62495	287	339	329	333	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2KTU
P62495	287	339	336	339	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2KTU

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
BLCA	ETF1	-5.5294928877253	0.000125885009765625
LUSC	ETF1	-1.14997231039675	0.000173983823784929
KIRC	ETF1	-2.84641542192603	0.00644033795389533
LUAD	ETF1	-2.01649649887837	2.27155024792558e-09

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
LIHC	ETF1	1	2	0.0117320808684995	0.181238095238095	0.275629648101967	-0.409318609609665	-0.605635023931154

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
THYM	ETF1	0.200658961	0.038047322

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with ETF1 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
DLBC	Cell metabolism gene	ETF1	HSPA9	0.815429019	1.70E-12
LAML	Cell metabolism gene	ETF1	PPP2CA	0.852826057	4.00E-50
LAML	Epifactor	ETF1	PPP2CA	0.852826057	4.00E-50
LAML	TSG	ETF1	PPP2CA	0.852826057	4.00E-50
TGCT	Cell metabolism gene	ETF1	PGAM4	0.809502314	1.91E-37
TGCT	Cell metabolism gene	ETF1	HSPA9	0.841548959	4.92E-43
TGCT	Cell metabolism gene	ETF1	PHAX	0.861857157	2.90E-47
THYM	Cell metabolism gene	ETF1	HSPA9	0.828879492	4.68E-32
UCS	Cell metabolism gene	ETF1	HSPA9	0.828879492	4.68E-32
UVM	Cell metabolism gene	ETF1	DLD	0.803575356	2.95E-19
UVM	Cell metabolism gene	ETF1	PPP2CA	0.803953545	2.76E-19
UVM	Cell metabolism gene	ETF1	PIK3C3	0.808140665	1.30E-19
UVM	Cell metabolism gene	ETF1	CLOCK	0.809831885	9.50E-20
UVM	Cell metabolism gene	ETF1	CNOT8	0.811747466	6.65E-20
UVM	Cell metabolism gene	ETF1	XRN2	0.818545704	1.82E-20
UVM	Cell metabolism gene	ETF1	TNPO1	0.825106247	4.94E-21
UVM	Cell metabolism gene	ETF1	COL4A3BP	0.844875538	6.84E-23
UVM	Cell metabolism gene	ETF1	HSPA9	0.871410007	7.70E-26
UVM	Cell metabolism gene	ETF1	PHAX	0.889445534	3.02E-28
UVM	CGC	ETF1	ATF1	0.80676423	1.67E-19
UVM	CGC	ETF1	AFF4	0.828684157	2.37E-21
UVM	Epifactor	ETF1	PPP2CA	0.803953545	2.76E-19
UVM	Epifactor	ETF1	ZRANB3	0.808688682	1.17E-19
UVM	Epifactor	ETF1	CLOCK	0.809831885	9.50E-20
UVM	Epifactor	ETF1	BRD8	0.8161121	2.91E-20
UVM	Epifactor	ETF1	WAC	0.824831125	5.23E-21
UVM	Epifactor	ETF1	TAF7	0.830125577	1.76E-21
UVM	Epifactor	ETF1	SKP1	0.859197636	2.08E-24
UVM	IUPHAR	ETF1	SCYL2	0.803188552	3.16E-19
UVM	IUPHAR	ETF1	PIK3C3	0.808140665	1.30E-19
UVM	IUPHAR	ETF1	CLOCK	0.809831885	9.50E-20
UVM	IUPHAR	ETF1	BRD8	0.8161121	2.91E-20
UVM	IUPHAR	ETF1	RIOK2	0.820011708	1.37E-20
UVM	IUPHAR	ETF1	USP14	0.835032965	6.18E-22
UVM	IUPHAR	ETF1	CSNK1A1	0.856487557	4.14E-24
UVM	IUPHAR	ETF1	SLC30A5	0.861424422	1.17E-24
UVM	Kinase	ETF1	SCYL2	0.803188552	3.16E-19
UVM	Kinase	ETF1	RIOK2	0.820011708	1.37E-20
UVM	Kinase	ETF1	COL4A3BP	0.844875538	6.84E-23
UVM	Kinase	ETF1	CSNK1A1	0.856487557	4.14E-24
UVM	TF	ETF1	ATF1	0.80676423	1.67E-19
UVM	TF	ETF1	CLOCK	0.809831885	9.50E-20
UVM	TF	ETF1	ZNF45	0.813732149	4.58E-20
UVM	TF	ETF1	GPBP1	0.813865376	4.47E-20
UVM	TSG	ETF1	PPP2CA	0.803953545	2.76E-19
UVM	TSG	ETF1	CSNK1A1	0.856487557	4.14E-24

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
THCA	ETF1	TRMT112	1.99321014253589	0.000102991650070565
BRCA	ETF1	UPF1	-1.33899089151335	0.000117696606626909
THCA	ETF1	GSPT1	1.07187187610031	0.000163107625527599
THCA	ETF1	N6AMT1	-1.16947119209261	0.000278681868396263
PRAD	ETF1	PA2G4	-1.39525821465227	0.000305145157975212
LUAD	ETF1	GSPT2	-2.14626058601833	0.000586888531715471
BRCA	ETF1	PA2G4	-1.29091766707702	0.000664421590817696
BRCA	ETF1	ABCE1	1.3740626146648	0.000669229587514616
COAD	ETF1	RPS20	-3.55214827660447	0.0010443925857544
LIHC	ETF1	ABCE1	1.33775121002715	0.0033398145023608
LIHC	ETF1	UPF1	-1.92491321082533	0.00427166918402987
KICH	ETF1	RPS20	-2.30757233561727	0.00612920522689819
HNSC	ETF1	GSPT2	1.05919071999191	0.00965754519575058
HNSC	ETF1	ABCE1	1.20332081233659	0.0124875666290336
BLCA	ETF1	ABCE1	-4.08863120087471	0.0229873657226562
LUAD	ETF1	SMG1	-1.40175658670625	0.0301695351050489
BLCA	ETF1	RPS20	-3.2869410015055	0.0360679626464844
LUSC	ETF1	GSPT2	-1.07022135846535	0.0407076861351475
LUAD	ETF1	EIF3B	-5.80435587546762	1.0542655358657e-09
PRAD	ETF1	ABCE1	-2.9089513514626	1.31460603050763e-05
LIHC	ETF1	PA2G4	-2.11966355213965	1.52957264107439e-06
KIRP	ETF1	RPS20	-1.44580921357944	1.60322524607182e-05
LUAD	ETF1	PA2G4	-1.77916485674617	2.04592776341023e-07
KIRC	ETF1	PA2G4	-1.18793742823904	2.15831756070263e-10
KIRC	ETF1	EIF3B	-1.56313263784517	2.35252849767166e-12
KIRP	ETF1	PA2G4	-1.71581840025124	2.49594449996948e-07
BRCA	ETF1	GSPT1	2.24014219081575	2.76767634190133e-17
STAD	ETF1	EIF3B	-4.7724660972007	3.25962901115418e-08
PRAD	ETF1	UPF1	1.18312136515194	3.77428293642232e-05
HNSC	ETF1	EIF3B	2.6202554263604	4.48234413852334e-06
KIRP	ETF1	EIF3B	-2.7592297042974	4.6566128730774e-09
KIRC	ETF1	TRMT112	-3.51311360529312	4.91010444643966e-09
KIRC	ETF1	GSPT2	-2.00602131161654	4.95376546353503e-10
STAD	ETF1	PA2G4	-2.25448780422398	6.68526627123356e-05
KIRC	ETF1	RPS20	-2.62380824779569	7.86590430905899e-10
KIRP	ETF1	GSPT2	-6.94360025987246	9.0546440333128e-05
BRCA	ETF1	TRMT112	-1.60214441868754	9.36519472684852e-13

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with ETF1

KEAP1, PABPC1, PPP2CA, GSPT2, GSPT1, UPF1, LIG4, ALB, HECW2, CORO1B, CORO1C, NUDC, RTF1, VPS26A, TSN, EGFR, ABCE1, MBD5, FSD1, ACTL6A, RNF26, CYP1A1, EIF2S1, EIF2S2, BZW1, DNAJB1, DNAJB4, HYOU1, LARS, NCKAP1, PDCD4, PSMA1, RPS7, SYAP1, ZPR1, XPO1, KPNB1, FGFR1OP, GEMIN5, SGTB, BAG6, Gspt1, Tube1, Mphosph9, SNRNP27, GTF2E2, FGB, USP47, MRPS11, SLC38A7, DLD, G3BP1, CCND2, HDAC4, EFTUD2, ARIH1, ESR2, UBE3A, AGR2, NR2C2, DCAF15, ZDHHC18, ZDHHC23, KRAS, ITFG1, BIRC3, PLEKHA4, PRKCB, RAB34, PGAM5, NDN, BRD4, Apc2, COPS5, RNF5, OGT, CD274, ATG7, ATG3, NAA40, RPL35A, HOXC5, DNAJB6, nsp1,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
ETF1	BLCA	chr5	137846256	137846256	C	G	Missense_Mutation	p.E361Q	5
ETF1	MESO	chr5	137853386	137853386	G	T	Missense_Mutation		3
ETF1	BRCA	chr5	137844062	137844062	G	A	Nonsense_Mutation	p.R416*	3
ETF1	UCEC	chr5	137853315	137853315	C	A	Missense_Mutation	p.D113Y	2
ETF1	LIHC	chr5	137844022	137844022	T	A	Missense_Mutation		2
ETF1	UCEC	chr5	137854380	137854380	C	T	Splice_Site	e2+1	2
ETF1	LIHC	chr5	137844000	137844000	G	A	Silent		2
ETF1	STAD	chr5	137848611	137848611	G	A	Missense_Mutation	p.R192C	2
ETF1	UCEC	chr5	137854413	137854413	G	A	Missense_Mutation	p.S77F	2
ETF1	STAD	chr5	137844015	137844015	A	C	Missense_Mutation	p.F431L	2
ETF1	UCEC	chr5	137878589	137878589	C	T	Missense_Mutation	p.A7T	2
ETF1	COAD	chr5	137846839	137846839	C	T	Missense_Mutation	p.V305I	2
ETF1	STAD	chr5	137844504	137844504	G	A	Missense_Mutation		2
ETF1	UCEC	chr5	137844068	137844068	G	A	Missense_Mutation	p.R414W	2
ETF1	LAML	chr5	137881160	137881160	A	C	Missense_Mutation	p.F131V	2
ETF1	CESC	chr5	137846755	137846755	G	A	Missense_Mutation		2
ETF1	UCEC	chr5	137844488	137844488	C	T	Silent	p.E367	2
ETF1	CESC	chr5	137847214	137847214	G	C	Missense_Mutation		2
ETF1	UCEC	chr5	137846286	137846286	C	A	Nonsense_Mutation	p.E351*	2
ETF1	CESC	chr5	137846286	137846286	C	T	Missense_Mutation		2
ETF1	UCEC	chr5	137853287	137853287	G	A	Missense_Mutation	p.T122M	2
ETF1	STAD	chr5	137844018	137844018	T	C	Silent	p.E430E	2
ETF1	SKCM	chr5	137853259	137853259	G	A	Silent	p.F98F	1
ETF1	BLCA	chr5	137846293	137846293	T	A	Silent		1
ETF1	STAD	chr5	137854386	137854386	T	C	Missense_Mutation	p.N86S	1
ETF1	CESC	chr5	137846755	137846755	G	A	Missense_Mutation	p.L333F	1
ETF1	LUSC	chr5	137878583	137878583	C	T	Missense_Mutation	p.D9N	1
ETF1	HNSC	chr5	137848560	137848560	C	T	Missense_Mutation	p.A176T	1
ETF1	SKCM	chr5	137844008	137844008	G	A	Missense_Mutation	p.L434F	1
ETF1	THCA	chr5	137878559	137878559	T	A	Missense_Mutation		1
ETF1	SKCM	chr5	137853289	137853289	A	G	Silent	p.N88N	1
ETF1	BLCA	chr5	137849377	137849377	A	C	Missense_Mutation	p.S108A	1
ETF1	CESC	chr5	137847214	137847214	G	C	Missense_Mutation	p.S271C	1
ETF1	THCA	chr5	137878559	137878559	T	A	Missense_Mutation	p.I17F	1
ETF1	HNSC	chr5	137847221	137847221	C	G	Missense_Mutation	p.E236Q	1
ETF1	SKCM	chr5	137853289	137853289	A	G	Silent	p.N121N	1
ETF1	SKCM	chr5	137853258	137853258	G	A	Missense_Mutation	p.H99Y	1
ETF1	BLCA	chr5	137846256	137846256	C	G	Missense_Mutation	p.E328Q	1
ETF1	LIHC	chr5	137844000	137844000	G	A	Silent	p.D436D	1
ETF1	COAD	chr5	137844392	137844392	C	T	Silent	p.G399G	1
ETF1	MESO	chr5	137878621	137878621	C	A	Missense_Mutation		1
ETF1	THCA	chr5	137844496	137844496	C	G	Missense_Mutation	p.E332Q	1
ETF1	HNSC	chr5	137847221	137847221	C	G	Missense_Mutation	p.E269Q	1
ETF1	SKCM	chr5	137849282	137849282	G	A	Silent	p.F172F	1
ETF1	SKCM	chr5	137846839	137846839	C	T	Missense_Mutation	p.V272I	1
ETF1	BLCA	chr5	137846293	137846293	T	A	Silent	p.P315P	1
ETF1	LIHC	chr5	137844022	137844022	T	A	Missense_Mutation	p.D429V	1
ETF1	COAD	chr5	137846306	137846306	A	G	Missense_Mutation	p.L344P	1
ETF1	OV	chr5	137854397	137854397	G	T	Silent	p.L82L	1
ETF1	STAD	chr5	137848517	137848517	C	T	Missense_Mutation	p.G190D	1
ETF1	THYM	chr5	137849392	137849392	G	T	Missense_Mutation		1
ETF1	KIRC	chr5	137848455	137848455	G	A	Nonsense_Mutation	p.Q244X	1
ETF1	SKCM	chr5	137844008	137844008	G	A	Missense_Mutation	p.L401F	1
ETF1	SKCM	chr5	137843997	137843997	G	C	Nonsense_Mutation	p.Y404*	1
ETF1	BLCA	chr5	137849377	137849377	A	C	Missense_Mutation	p.S141A	1
ETF1	LIHC	chr5	137844500	137844500	T	C	Silent	p.G363G	1
ETF1	OV	chr5	137853274	137853274	C	G	Missense_Mutation	p.L126F	1
ETF1	STAD	chr5	137854440	137854440	C	T	Missense_Mutation	p.R35H	1
ETF1	THYM	chr5	137849392	137849392	G	T	Missense_Mutation	p.L136I	1
ETF1	KIRC	chr5	137846859	137846862	GTGT	-	Frame_Shift_Del	p.297_298del	1
ETF1	SKCM	chr5	137849282	137849282	G	A	Silent	p.F139F	1
ETF1	STAD	chr5	137846299	137846302	TAGA	-	Frame_Shift_Del		1
ETF1	LIHC	chr5	137844022	137844022	T	A	Missense_Mutation	p.D396V	1
ETF1	GBM	chr5	137848498	137848498	G	T	Silent	p.S229S	1
ETF1	PAAD	chr5	137844426	137844426	G	A	Missense_Mutation	p.T388M	1
ETF1	STAD	chr5	137853386	137853386	G	A	Missense_Mutation	p.P56L	1
ETF1	UCEC	chr5	137848491	137848491	A	C	Missense_Mutation	p.F232V	1
ETF1	KIRC	chr5	137846859	137846862	GTGT	-	Frame_Shift_Del	p.DT264fs	1
ETF1	SKCM	chr5	137848536	137848536	C	T	Missense_Mutation	p.D184N	1
ETF1	LIHC	chr5	137844000	137844000	G	A	Silent	p.D403D	1
ETF1	GBM	chr5	137846888	137846888	T	C	Silent	p.G288_splice	1
ETF1	PRAD	chr5	137848593	137848593	G	A	Nonsense_Mutation	p.R165*	1
ETF1	STAD	chr5	137844504	137844504	G	A	Splice_Site	p.T329_splice	1
ETF1	STAD	chr5	137846299	137846302	TAGA	-	Frame_Shift_Del	p.346_347del	1
ETF1	LIHC	chr5	137853380	137853380	T	-	Frame_Shift_Del	p.N58fs	1
ETF1	GBM	chr5	137846307	137846307	G	A	Missense_Mutation		1
ETF1	PRAD	chr5	137853306	137853306	G	T	Missense_Mutation	p.P83T	1
ETF1	STAD	chr5	137846299	137846302	TAGA	-	Frame_Shift_Del	p.YL312fs	1
ETF1	LGG	chr5	137878583	137878583	C	A	Missense_Mutation		1
ETF1	STAD	chr5	137853386	137853386	G	A	Missense_Mutation	p.P89L	1
ETF1	LIHC	chr5	137844392	137844392	C	-	Frame_Shift_Del	p.G366fs	1
ETF1	GBM	chr5	137846888	137846888	T	C	Silent		1
ETF1	PRAD	chr5	137844470	137844470	G	T	Silent	p.P340P	1
ETF1	STAD	chr5	137844390	137844390	G	A	Missense_Mutation	p.S400F	1
ETF1	BLCA	chr5	137849377	137849377	A	C	Missense_Mutation		1
ETF1	LIHC	chr5	137853325	137853325	T	C	Silent		1
ETF1	STAD	chr5	137844504	137844504	G	A	Missense_Mutation	p.T362I	1
ETF1	LIHC	chr5	137849265	137849265	T	-	Frame_Shift_Del	p.K146fs	1
ETF1	HNSC	chr5	137847221	137847221	C	G	Missense_Mutation		1
ETF1	READ	chr5	137847174	137847174	C	A	Missense_Mutation	p.K284N	1
ETF1	STAD	chr5	137854434	137854434	G	A	Missense_Mutation	p.S70L	1
ETF1	BLCA	chr5	137846256	137846256	C	G	Missense_Mutation		1
ETF1	LIHC	chr5	137853285	137853285	A	G	Missense_Mutation		1
ETF1	CESC	chr5	137846286	137846286	C	T	Missense_Mutation	p.E351K	1
ETF1	LUSC	chr5	137878559	137878559	T	C	Missense_Mutation	p.I17V	1
ETF1	HNSC	chr5	137848560	137848560	C	T	Missense_Mutation		1
ETF1	SARC	chr5	137849282	137849282	G	T	Missense_Mutation		1
ETF1	THCA	chr5	137844496	137844496	C	G	Missense_Mutation		1

Copy number variation (CNV) of ETF1
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across ETF1
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
99153	BRCA	TCGA-A2-A0EP	ARHGEF37	chr5	148961187	+	ETF1	chr5	137854556	-
99153	STAD	TCGA-BR-8372-01A	CHPT1	chr12	102091912	+	ETF1	chr5	137854556	-
98691	N/A	X80916	ETF1	chr5	137843130	-	ASIC2	chr17	32232191	-
99153	N/A	AA654773	ETF1	chr5	137842199	-	ETF1	chr5	137842156	+
103197	PAAD	TCGA-LB-A9Q5	ETF1	chr5	137878522	-	HSPA9	chr5	137897478	-
76627	N/A	BM987663	ETF1	chr5	137853891	-	MFSD12	chr19	3538273	+
38226	PRAD	TCGA-HC-8259-01A	ETF1	chr5	137878522	-	TRAPPC13	chr5	64954195	+
99153	N/A	BG534374	HLA-E	chr6	30457673	+	ETF1	chr5	137848637	-
99153	N/A	BE836686	LOXL4	chr10	100008202	-	ETF1	chr5	137843350	-
99153	SKCM	TCGA-EE-A2M7	MGAT4B	chr5	179233486	-	ETF1	chr5	137854556	-
99153	SKCM	TCGA-EE-A2M7-06A	MGAT4B	chr5	179233487	-	ETF1	chr5	137854556	-
99153	N/A	CB050250	RP11-405A12.2	chr12	19951868	-	ETF1	chr5	137841784	+
99153	N/A	AB037752	SENP2	chr3	185348999	+	ETF1	chr5	137564604	+
99154	STAD	TCGA-CD-8531-01A	WDYHV1	chr8	124449574	+	ETF1	chr5	137849395	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
READ	ETF1	0.00107926546586835	0.03
HNSC	ETF1	0.0250886757765738	0.68
KIRP	ETF1	0.0325015905783928	0.85
TGCT	ETF1	0.0392398512040779	0.98

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUAD	ETF1	0.0321547745414193	1
KIRC	ETF1	0.00692207182660415	0.23
OV	ETF1	0.0377335653514237	1
THYM	ETF1	0.0236451359994409	0.76

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source