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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: PTK2B (NCBI Gene ID:2185)

Gene Summary

Gene Summary

Gene Information	Gene Name: PTK2B
	Gene ID: 2185
	Gene Symbol	PTK2B
	Gene ID	2185
	Gene Name	protein tyrosine kinase 2 beta
	Synonyms	CADTK\|CAKB\|FADK2\|FAK2\|PKB\|PTK\|PYK2\|RAFTK
	Cytomap	8p21.2
	Type of Gene	protein-coding
	Description	protein-tyrosine kinase 2-betaCAK-betaFADK 2PTK2B protein tyrosine kinase 2 betacalcium-dependent tyrosine kinasecalcium-regulated non-receptor proline-rich tyrosine kinasecell adhesion kinase betafocal adhesion kinase 2proline-rich tyrosine kinas
	Modification date	20200313
	UniProtAcc	Q14289

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0045727	Positive regulation of translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PTK2B	GO:0010595	positive regulation of endothelial cell migration	21245381
Hgene	PTK2B	GO:0018108	peptidyl-tyrosine phosphorylation	7544443
Hgene	PTK2B	GO:0038083	peptidyl-tyrosine autophosphorylation	9545257\|10518561
Hgene	PTK2B	GO:0043267	negative regulation of potassium ion transport	7544443
Hgene	PTK2B	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	10022914\|10518561\|21245381
Hgene	PTK2B	GO:2000058	regulation of ubiquitin-dependent protein catabolic process	19880522

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
PTK2B	(733 - 1119.25]

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Translation Studies in PubMed

We searched PubMed using 'PTK2B[title] AND translation [title] AND human.'

Gene	Title	PMID
PTK2B	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000397501	27180783	27180943	5UTR-5UTR
ENST00000346049	27255064	27255305	5CDS-5UTR
ENST00000397501	27255064	27255305	5CDS-5UTR
ENST00000346049	27279820	27279900	Frame-shift
ENST00000397501	27279820	27279900	Frame-shift
ENST00000346049	27289776	27289878	In-frame
ENST00000397501	27289776	27289878	In-frame
ENST00000346049	27290951	27291069	Frame-shift
ENST00000397501	27290951	27291069	Frame-shift
ENST00000346049	27293767	27293865	Frame-shift
ENST00000397501	27293767	27293865	Frame-shift
ENST00000346049	27294638	27294723	Frame-shift
ENST00000397501	27294638	27294723	Frame-shift
ENST00000346049	27297753	27297958	Frame-shift
ENST00000397501	27297753	27297958	Frame-shift
ENST00000346049	27303310	27303436	In-frame
ENST00000397501	27303310	27303436	In-frame
ENST00000346049	27308559	27308595	In-frame
ENST00000397501	27308559	27308595	In-frame
ENST00000346049	27312047	27312128	In-frame
ENST00000397501	27312047	27312128	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000346049	27289776	27289878	4164	1126	1227	1009	295	329
ENST00000397501	27289776	27289878	4732	1694	1795	1009	295	329
ENST00000346049	27303310	27303436	4164	2455	2580	1009	738	780
ENST00000397501	27303310	27303436	4732	3023	3148	1009	738	780
ENST00000346049	27308559	27308595	4164	2728	2763	1009	829	841
ENST00000397501	27308559	27308595	4732	3296	3331	1009	829	841
ENST00000346049	27312047	27312128	4164	2974	3054	1009	911	938
ENST00000397501	27312047	27312128	4732	3542	3622	1009	911	938

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
Q14289	738	780	1	1009	Chain	ID=PRO_0000088081;Note=Protein-tyrosine kinase 2-beta
Q14289	911	938	1	1009	Chain	ID=PRO_0000088081;Note=Protein-tyrosine kinase 2-beta
Q14289	829	841	1	1009	Chain	ID=PRO_0000088081;Note=Protein-tyrosine kinase 2-beta
Q14289	295	329	1	1009	Chain	ID=PRO_0000088081;Note=Protein-tyrosine kinase 2-beta
Q14289	738	780	1	1009	Chain	ID=PRO_0000088081;Note=Protein-tyrosine kinase 2-beta
Q14289	911	938	1	1009	Chain	ID=PRO_0000088081;Note=Protein-tyrosine kinase 2-beta
Q14289	829	841	1	1009	Chain	ID=PRO_0000088081;Note=Protein-tyrosine kinase 2-beta
Q14289	295	329	1	1009	Chain	ID=PRO_0000088081;Note=Protein-tyrosine kinase 2-beta
Q14289	295	329	39	359	Domain	Note=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00084
Q14289	295	329	39	359	Domain	Note=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00084
Q14289	911	938	801	1009	Region	Note=Interaction with TGFB1I1;Ontology_term=ECO:0000250;evidence=ECO:0000250
Q14289	829	841	801	1009	Region	Note=Interaction with TGFB1I1;Ontology_term=ECO:0000250;evidence=ECO:0000250
Q14289	911	938	801	1009	Region	Note=Interaction with TGFB1I1;Ontology_term=ECO:0000250;evidence=ECO:0000250
Q14289	829	841	801	1009	Region	Note=Interaction with TGFB1I1;Ontology_term=ECO:0000250;evidence=ECO:0000250
Q14289	911	938	868	1009	Region	Note=Focal adhesion targeting (FAT)
Q14289	911	938	868	1009	Region	Note=Focal adhesion targeting (FAT)
Q14289	738	780	702	767	Compositional bias	Note=Pro-rich
Q14289	738	780	702	767	Compositional bias	Note=Pro-rich
Q14289	829	841	831	869	Compositional bias	Note=Pro-rich
Q14289	829	841	831	869	Compositional bias	Note=Pro-rich
Q14289	738	780	762	762	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:19369195;Dbxref=PMID:19369195
Q14289	738	780	762	762	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:19369195;Dbxref=PMID:19369195
Q14289	738	780	765	765	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:18691976;Dbxref=PMID:18691976
Q14289	738	780	765	765	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:18691976;Dbxref=PMID:18691976
Q14289	829	841	834	834	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:19369195;Dbxref=PMID:19369195
Q14289	829	841	834	834	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:19369195;Dbxref=PMID:19369195
Q14289	829	841	839	839	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18691976,ECO:0000244\|PubMed:19369195;Dbxref=PMID:18691976,PMID:19369195
Q14289	829	841	839	839	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18691976,ECO:0000244\|PubMed:19369195;Dbxref=PMID:18691976,PMID:19369195
Q14289	738	780	739	780	Alternative sequence	ID=VSP_004981;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:9545257;Dbxref=PMID:9545257
Q14289	738	780	739	780	Alternative sequence	ID=VSP_004981;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:9545257;Dbxref=PMID:9545257
Q14289	829	841	838	838	Natural variant	ID=VAR_020284;Note=K->T;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244\|PubMed:19369195,ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs751019,PMID:19369195,PMID:17344846
Q14289	829	841	838	838	Natural variant	ID=VAR_020284;Note=K->T;Ontology_term=ECO:0000244,ECO:0000269;evidence=ECO:0000244\|PubMed:19369195,ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs751019,PMID:19369195,PMID:17344846
Q14289	738	780	780	780	Sequence conflict	Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q14289	738	780	780	780	Sequence conflict	Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q14289	295	329	297	300	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4EKU
Q14289	295	329	297	300	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4EKU
Q14289	295	329	302	304	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4EKU
Q14289	295	329	302	304	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4EKU
Q14289	295	329	310	313	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4EKU
Q14289	295	329	310	313	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4EKU
Q14289	295	329	314	316	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4EKU
Q14289	295	329	314	316	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4EKU
Q14289	295	329	317	322	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4EKU
Q14289	295	329	317	322	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4EKU
Q14289	911	938	906	927	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4XEK
Q14289	911	938	906	927	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4XEK
Q14289	911	938	928	930	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4XEK
Q14289	911	938	928	930	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4XEK
Q14289	911	938	933	962	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4XEK
Q14289	911	938	933	962	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4XEK

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
LIHC	PTK2B	1.04756360486933	0.0019437011899127
CHOL	PTK2B	1.58722942330802	0.0078125
HNSC	PTK2B	2.1180426350347	0.01079356217042
LUAD	PTK2B	-5.18037131106719	2.27155024792558e-09
COAD	PTK2B	-1.99774932339641	4.08291816711426e-06
LUSC	PTK2B	-2.70948390338998	6.29312025683038e-07
THCA	PTK2B	2.37255492093485	6.92798300625088e-08

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
MESO	PTK2B	hsa-miR-23a-3p	77	0.31039435248296	0.00554802190297727

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
SARC	PTK2B	-0.200881011	0.037070699

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with PTK2B (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
LGG	IUPHAR	PTK2B	HIPK4	0.800394484	1.99E-119
LGG	IUPHAR	PTK2B	HTR3B	0.803663806	4.09E-121
LGG	IUPHAR	PTK2B	ITPR1	0.806009578	2.41E-122
LGG	IUPHAR	PTK2B	PAK6	0.807864568	2.49E-123
LGG	IUPHAR	PTK2B	CAMKK1	0.813676637	1.74E-126
LGG	IUPHAR	PTK2B	PAK1	0.816706565	3.55E-128
LGG	IUPHAR	PTK2B	NPTN	0.822012493	3.26E-131
LGG	Kinase	PTK2B	HIPK4	0.800394484	1.99E-119
LGG	Kinase	PTK2B	PAK6	0.807864568	2.49E-123
LGG	Kinase	PTK2B	CAMKK1	0.813676637	1.74E-126
LGG	Kinase	PTK2B	PAK1	0.816706565	3.55E-128
LGG	TF	PTK2B	STAT4	0.815206675	2.46E-127
SKCM	CGC	PTK2B	PTPN6	0.804146505	1.08E-108
SKCM	CGC	PTK2B	IKZF1	0.805555139	2.37E-109
SKCM	CGC	PTK2B	CARD11	0.819812363	2.33E-116
SKCM	Epifactor	PTK2B	IKZF1	0.805555139	2.37E-109
SKCM	IUPHAR	PTK2B	NCR3	0.801143985	2.66E-107
SKCM	IUPHAR	PTK2B	S1PR4	0.814332291	1.36E-113
SKCM	IUPHAR	PTK2B	INPP5D	0.814408177	1.24E-113
SKCM	IUPHAR	PTK2B	CD37	0.816714678	8.75E-115
SKCM	TF	PTK2B	IKZF1	0.805555139	2.37E-109
SKCM	TSG	PTK2B	PTPN6	0.804146505	1.08E-108
SKCM	TSG	PTK2B	IKZF1	0.805555139	2.37E-109
TGCT	Cell metabolism gene	PTK2B	PLCG2	0.815283163	2.26E-38
TGCT	CGC	PTK2B	TNFRSF14	0.80699697	4.71E-37
TGCT	IUPHAR	PTK2B	CD37	0.801177515	3.65E-36
TGCT	IUPHAR	PTK2B	TNFRSF14	0.80699697	4.71E-37
TGCT	IUPHAR	PTK2B	PLCG2	0.815283163	2.26E-38
TGCT	IUPHAR	PTK2B	RIPK3	0.836059947	5.42E-42
TGCT	Kinase	PTK2B	RIPK3	0.836059947	5.42E-42
THYM	Cell metabolism gene	PTK2B	PDE7A	0.803151521	9.22E-29
THYM	Cell metabolism gene	PTK2B	NUP50	0.81392461	4.44E-30
THYM	Cell metabolism gene	PTK2B	PAFAH2	0.827119197	8.19E-32
THYM	Cell metabolism gene	PTK2B	CD38	0.83725503	3.00E-33
THYM	Cell metabolism gene	PTK2B	PIP4K2A	0.84071171	9.24E-34
THYM	Cell metabolism gene	PTK2B	GNG2	0.861484958	4.04E-37
THYM	Cell metabolism gene	PTK2B	DGKA	0.899539061	5.56E-45
THYM	CGC	PTK2B	CCND3	0.806251962	3.93E-29
THYM	CGC	PTK2B	EZH2	0.808284373	2.23E-29
THYM	CGC	PTK2B	LEF1	0.813948072	4.41E-30
THYM	CGC	PTK2B	CDKN2C	0.815201002	3.06E-30
THYM	CGC	PTK2B	LCP1	0.819619527	8.25E-31
THYM	CGC	PTK2B	RAP1GDS1	0.821337272	4.91E-31
THYM	CGC	PTK2B	BCL11B	0.827522966	7.21E-32
THYM	CGC	PTK2B	ITK	0.828056902	6.08E-32
THYM	CGC	PTK2B	LEPROTL1	0.828164357	5.88E-32
THYM	CGC	PTK2B	RHOH	0.83669766	3.62E-33
THYM	CGC	PTK2B	VAV1	0.837302203	2.96E-33
THYM	CGC	PTK2B	LCK	0.843856028	3.08E-34
THYM	CGC	PTK2B	PRKCB	0.845347393	1.82E-34
THYM	CGC	PTK2B	P2RY8	0.856834074	2.54E-36
THYM	CGC	PTK2B	FNBP1	0.860867885	5.17E-37
THYM	CGC	PTK2B	WAS	0.86622335	5.80E-38
THYM	CGC	PTK2B	CXCR4	0.876321127	7.14E-40
THYM	CGC	PTK2B	IKZF1	0.884545193	1.48E-41
THYM	Epifactor	PTK2B	EZH2	0.808284373	2.23E-29
THYM	Epifactor	PTK2B	PHF19	0.811507336	8.92E-30
THYM	Epifactor	PTK2B	GFI1	0.821702962	4.39E-31
THYM	Epifactor	PTK2B	MSL3	0.821762481	4.31E-31
THYM	Epifactor	PTK2B	PRKCB	0.845347393	1.82E-34
THYM	Epifactor	PTK2B	IKZF1	0.884545193	1.48E-41
THYM	IUPHAR	PTK2B	RGS10	0.803065233	9.44E-29
THYM	IUPHAR	PTK2B	PDE7A	0.803151521	9.22E-29
THYM	IUPHAR	PTK2B	EZH2	0.808284373	2.23E-29
THYM	IUPHAR	PTK2B	ADORA2A	0.810673718	1.13E-29
THYM	IUPHAR	PTK2B	KCNA3	0.811929999	7.90E-30
THYM	IUPHAR	PTK2B	CAMK4	0.813551493	4.95E-30
THYM	IUPHAR	PTK2B	CHRNA2	0.814492333	3.77E-30
THYM	IUPHAR	PTK2B	RORC	0.815530323	2.78E-30
THYM	IUPHAR	PTK2B	STK38	0.815805734	2.56E-30
THYM	IUPHAR	PTK2B	SLC46A3	0.815951145	2.46E-30
THYM	IUPHAR	PTK2B	CYP2U1	0.822306188	3.65E-31
THYM	IUPHAR	PTK2B	ICOS	0.823233051	2.75E-31
THYM	IUPHAR	PTK2B	IRAK4	0.825721092	1.27E-31
THYM	IUPHAR	PTK2B	PAFAH2	0.827119197	8.19E-32
THYM	IUPHAR	PTK2B	ITK	0.828056902	6.08E-32
THYM	IUPHAR	PTK2B	PRKCQ	0.831588809	1.96E-32
THYM	IUPHAR	PTK2B	ATP8B3	0.836864822	3.43E-33
THYM	IUPHAR	PTK2B	CD38	0.83725503	3.00E-33
THYM	IUPHAR	PTK2B	CD52	0.840695017	9.29E-34
THYM	IUPHAR	PTK2B	PIP4K2A	0.84071171	9.24E-34
THYM	IUPHAR	PTK2B	CD2	0.842688677	4.65E-34
THYM	IUPHAR	PTK2B	LCK	0.843856028	3.08E-34
THYM	IUPHAR	PTK2B	LAIR1	0.844075926	2.85E-34
THYM	IUPHAR	PTK2B	PRKCB	0.845347393	1.82E-34
THYM	IUPHAR	PTK2B	ITGAL	0.845493054	1.72E-34
THYM	IUPHAR	PTK2B	CD37	0.845918938	1.48E-34
THYM	IUPHAR	PTK2B	FYN	0.848214403	6.46E-35
THYM	IUPHAR	PTK2B	MAP2K6	0.849017019	4.82E-35
THYM	IUPHAR	PTK2B	IL2RG	0.851006972	2.32E-35
THYM	IUPHAR	PTK2B	MAP4K1	0.854513692	6.19E-36
THYM	IUPHAR	PTK2B	RASGRP1	0.85567476	3.97E-36
THYM	IUPHAR	PTK2B	P2RY8	0.856834074	2.54E-36
THYM	IUPHAR	PTK2B	NLRC3	0.858413929	1.37E-36
THYM	IUPHAR	PTK2B	CD6	0.859464926	9.04E-37
THYM	IUPHAR	PTK2B	CD3E	0.864493175	1.19E-37
THYM	IUPHAR	PTK2B	CD4	0.865666534	7.31E-38
THYM	IUPHAR	PTK2B	CD247	0.872716868	3.58E-39
THYM	IUPHAR	PTK2B	SEMA4D	0.875466297	1.05E-39
THYM	IUPHAR	PTK2B	CXCR4	0.876321127	7.14E-40
THYM	IUPHAR	PTK2B	PVRIG	0.877300338	4.57E-40
THYM	IUPHAR	PTK2B	GRK6	0.899661864	5.19E-45
THYM	Kinase	PTK2B	CAMK4	0.813551493	4.95E-30
THYM	Kinase	PTK2B	STK38	0.815805734	2.56E-30
THYM	Kinase	PTK2B	ADRBK1	0.82111856	5.24E-31
THYM	Kinase	PTK2B	IRAK4	0.825721092	1.27E-31
THYM	Kinase	PTK2B	ITK	0.828056902	6.08E-32
THYM	Kinase	PTK2B	PRKCQ	0.831588809	1.96E-32
THYM	Kinase	PTK2B	LCK	0.843856028	3.08E-34
THYM	Kinase	PTK2B	PRKCB	0.845347393	1.82E-34
THYM	Kinase	PTK2B	FYN	0.848214403	6.46E-35
THYM	Kinase	PTK2B	MAP2K6	0.849017019	4.82E-35
THYM	Kinase	PTK2B	MAP4K1	0.854513692	6.19E-36
THYM	Kinase	PTK2B	GRK6	0.899661864	5.19E-45
THYM	TF	PTK2B	TCF7	0.804251211	6.82E-29
THYM	TF	PTK2B	LEF1	0.813948072	4.41E-30
THYM	TF	PTK2B	RORC	0.815530323	2.78E-30
THYM	TF	PTK2B	NFATC3	0.8162414	2.25E-30
THYM	TF	PTK2B	GFI1	0.821702962	4.39E-31
THYM	TF	PTK2B	BCL11B	0.827522966	7.21E-32
THYM	TF	PTK2B	HSF5	0.830901399	2.45E-32
THYM	TF	PTK2B	ZNF101	0.847763492	7.62E-35
THYM	TF	PTK2B	IKZF1	0.884545193	1.48E-41
THYM	TF	PTK2B	AKNA	0.899700379	5.08E-45
THYM	TSG	PTK2B	EZH2	0.808284373	2.23E-29
THYM	TSG	PTK2B	CDKN2C	0.815201002	3.06E-30
THYM	TSG	PTK2B	RASSF5	0.816236911	2.26E-30
THYM	TSG	PTK2B	PRKCB	0.845347393	1.82E-34
THYM	TSG	PTK2B	MAP4K1	0.854513692	6.19E-36
THYM	TSG	PTK2B	CD4	0.865666534	7.31E-38
THYM	TSG	PTK2B	IKZF1	0.884545193	1.48E-41
UCS	Cell metabolism gene	PTK2B	PDE7A	0.803151521	9.22E-29
UCS	Cell metabolism gene	PTK2B	NUP50	0.81392461	4.44E-30
UCS	Cell metabolism gene	PTK2B	PAFAH2	0.827119197	8.19E-32
UCS	Cell metabolism gene	PTK2B	CD38	0.83725503	3.00E-33
UCS	Cell metabolism gene	PTK2B	PIP4K2A	0.84071171	9.24E-34
UCS	Cell metabolism gene	PTK2B	GNG2	0.861484958	4.04E-37
UCS	Cell metabolism gene	PTK2B	DGKA	0.899539061	5.56E-45
UCS	CGC	PTK2B	CCND3	0.806251962	3.93E-29
UCS	CGC	PTK2B	EZH2	0.808284373	2.23E-29
UCS	CGC	PTK2B	LEF1	0.813948072	4.41E-30
UCS	CGC	PTK2B	CDKN2C	0.815201002	3.06E-30
UCS	CGC	PTK2B	LCP1	0.819619527	8.25E-31
UCS	CGC	PTK2B	RAP1GDS1	0.821337272	4.91E-31
UCS	CGC	PTK2B	BCL11B	0.827522966	7.21E-32
UCS	CGC	PTK2B	ITK	0.828056902	6.08E-32
UCS	CGC	PTK2B	LEPROTL1	0.828164357	5.88E-32
UCS	CGC	PTK2B	RHOH	0.83669766	3.62E-33
UCS	CGC	PTK2B	VAV1	0.837302203	2.96E-33
UCS	CGC	PTK2B	LCK	0.843856028	3.08E-34
UCS	CGC	PTK2B	PRKCB	0.845347393	1.82E-34
UCS	CGC	PTK2B	P2RY8	0.856834074	2.54E-36
UCS	CGC	PTK2B	FNBP1	0.860867885	5.17E-37
UCS	CGC	PTK2B	WAS	0.86622335	5.80E-38
UCS	CGC	PTK2B	CXCR4	0.876321127	7.14E-40
UCS	CGC	PTK2B	IKZF1	0.884545193	1.48E-41
UCS	Epifactor	PTK2B	EZH2	0.808284373	2.23E-29
UCS	Epifactor	PTK2B	PHF19	0.811507336	8.92E-30
UCS	Epifactor	PTK2B	GFI1	0.821702962	4.39E-31
UCS	Epifactor	PTK2B	MSL3	0.821762481	4.31E-31
UCS	Epifactor	PTK2B	PRKCB	0.845347393	1.82E-34
UCS	Epifactor	PTK2B	IKZF1	0.884545193	1.48E-41
UCS	IUPHAR	PTK2B	RGS10	0.803065233	9.44E-29
UCS	IUPHAR	PTK2B	PDE7A	0.803151521	9.22E-29
UCS	IUPHAR	PTK2B	EZH2	0.808284373	2.23E-29
UCS	IUPHAR	PTK2B	ADORA2A	0.810673718	1.13E-29
UCS	IUPHAR	PTK2B	KCNA3	0.811929999	7.90E-30
UCS	IUPHAR	PTK2B	CAMK4	0.813551493	4.95E-30
UCS	IUPHAR	PTK2B	CHRNA2	0.814492333	3.77E-30
UCS	IUPHAR	PTK2B	RORC	0.815530323	2.78E-30
UCS	IUPHAR	PTK2B	STK38	0.815805734	2.56E-30
UCS	IUPHAR	PTK2B	SLC46A3	0.815951145	2.46E-30
UCS	IUPHAR	PTK2B	CYP2U1	0.822306188	3.65E-31
UCS	IUPHAR	PTK2B	ICOS	0.823233051	2.75E-31
UCS	IUPHAR	PTK2B	IRAK4	0.825721092	1.27E-31
UCS	IUPHAR	PTK2B	PAFAH2	0.827119197	8.19E-32
UCS	IUPHAR	PTK2B	ITK	0.828056902	6.08E-32
UCS	IUPHAR	PTK2B	PRKCQ	0.831588809	1.96E-32
UCS	IUPHAR	PTK2B	ATP8B3	0.836864822	3.43E-33
UCS	IUPHAR	PTK2B	CD38	0.83725503	3.00E-33
UCS	IUPHAR	PTK2B	CD52	0.840695017	9.29E-34
UCS	IUPHAR	PTK2B	PIP4K2A	0.84071171	9.24E-34
UCS	IUPHAR	PTK2B	CD2	0.842688677	4.65E-34
UCS	IUPHAR	PTK2B	LCK	0.843856028	3.08E-34
UCS	IUPHAR	PTK2B	LAIR1	0.844075926	2.85E-34
UCS	IUPHAR	PTK2B	PRKCB	0.845347393	1.82E-34
UCS	IUPHAR	PTK2B	ITGAL	0.845493054	1.72E-34
UCS	IUPHAR	PTK2B	CD37	0.845918938	1.48E-34
UCS	IUPHAR	PTK2B	FYN	0.848214403	6.46E-35
UCS	IUPHAR	PTK2B	MAP2K6	0.849017019	4.82E-35
UCS	IUPHAR	PTK2B	IL2RG	0.851006972	2.32E-35
UCS	IUPHAR	PTK2B	MAP4K1	0.854513692	6.19E-36
UCS	IUPHAR	PTK2B	RASGRP1	0.85567476	3.97E-36
UCS	IUPHAR	PTK2B	P2RY8	0.856834074	2.54E-36
UCS	IUPHAR	PTK2B	NLRC3	0.858413929	1.37E-36
UCS	IUPHAR	PTK2B	CD6	0.859464926	9.04E-37
UCS	IUPHAR	PTK2B	CD3E	0.864493175	1.19E-37
UCS	IUPHAR	PTK2B	CD4	0.865666534	7.31E-38
UCS	IUPHAR	PTK2B	CD247	0.872716868	3.58E-39
UCS	IUPHAR	PTK2B	SEMA4D	0.875466297	1.05E-39
UCS	IUPHAR	PTK2B	CXCR4	0.876321127	7.14E-40
UCS	IUPHAR	PTK2B	PVRIG	0.877300338	4.57E-40
UCS	IUPHAR	PTK2B	GRK6	0.899661864	5.19E-45
UCS	Kinase	PTK2B	CAMK4	0.813551493	4.95E-30
UCS	Kinase	PTK2B	STK38	0.815805734	2.56E-30
UCS	Kinase	PTK2B	ADRBK1	0.82111856	5.24E-31
UCS	Kinase	PTK2B	IRAK4	0.825721092	1.27E-31
UCS	Kinase	PTK2B	ITK	0.828056902	6.08E-32
UCS	Kinase	PTK2B	PRKCQ	0.831588809	1.96E-32
UCS	Kinase	PTK2B	LCK	0.843856028	3.08E-34
UCS	Kinase	PTK2B	PRKCB	0.845347393	1.82E-34
UCS	Kinase	PTK2B	FYN	0.848214403	6.46E-35
UCS	Kinase	PTK2B	MAP2K6	0.849017019	4.82E-35
UCS	Kinase	PTK2B	MAP4K1	0.854513692	6.19E-36
UCS	Kinase	PTK2B	GRK6	0.899661864	5.19E-45
UCS	TF	PTK2B	TCF7	0.804251211	6.82E-29
UCS	TF	PTK2B	LEF1	0.813948072	4.41E-30
UCS	TF	PTK2B	RORC	0.815530323	2.78E-30
UCS	TF	PTK2B	NFATC3	0.8162414	2.25E-30
UCS	TF	PTK2B	GFI1	0.821702962	4.39E-31
UCS	TF	PTK2B	BCL11B	0.827522966	7.21E-32
UCS	TF	PTK2B	HSF5	0.830901399	2.45E-32
UCS	TF	PTK2B	ZNF101	0.847763492	7.62E-35
UCS	TF	PTK2B	IKZF1	0.884545193	1.48E-41
UCS	TF	PTK2B	AKNA	0.899700379	5.08E-45
UCS	TSG	PTK2B	EZH2	0.808284373	2.23E-29
UCS	TSG	PTK2B	CDKN2C	0.815201002	3.06E-30
UCS	TSG	PTK2B	RASSF5	0.816236911	2.26E-30
UCS	TSG	PTK2B	PRKCB	0.845347393	1.82E-34
UCS	TSG	PTK2B	MAP4K1	0.854513692	6.19E-36
UCS	TSG	PTK2B	CD4	0.865666534	7.31E-38
UCS	TSG	PTK2B	IKZF1	0.884545193	1.48E-41

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRC	PTK2B	GRB2	-3.50962289529079	0.000210123708729258
LIHC	PTK2B	GRB2	-2.6070669266439	0.000329386776931513
KICH	PTK2B	PXN	1.38464540346535	0.000489473342895508
LIHC	PTK2B	LPXN	1.50949708391646	0.000510510057211325
KIRP	PTK2B	SHC1	-1.28530866485745	0.000906126573681831
STAD	PTK2B	TGFB1I1	-1.25408571292859	0.000906126573681831
COAD	PTK2B	TGFB1I1	-2.11779857229408	0.000934779644012452
LUSC	PTK2B	GRB2	-1.60175668402919	0.00116257561090457
KIRP	PTK2B	PXN	-2.47353416582096	0.00133262807503343
ESCA	PTK2B	SRC	1.0077300524118	0.001953125
KIRP	PTK2B	FYN	1.44983853213539	0.00239070039242506
KIRC	PTK2B	PTPN11	-1.04569475255792	0.00255892408754689
LUAD	PTK2B	ITGB3	2.28163338327198	0.00378388437875256
CHOL	PTK2B	PXN	-3.15724493726714	0.0078125
COAD	PTK2B	PTPN11	-2.73881439079228	0.00938254594802858
CHOL	PTK2B	GRB2	-1.28858368343854	0.01171875
UCEC	PTK2B	LPXN	1.21168148158441	0.046875
HNSC	PTK2B	GRB2	-2.71037834855917	1.00141839993739e-05
THCA	PTK2B	SHC1	-1.92572983257134	1.13787415943499e-05
BRCA	PTK2B	TGFB1I1	-4.32175984811843	1.4167244661077e-17
THCA	PTK2B	BCAR1	-2.97625548467167	1.80517335668098e-06
KICH	PTK2B	GRB2	1.69470901099239	2.5629997253418e-06
KICH	PTK2B	ITGB3	-1.27836900939953	3.19480895996094e-05
LUAD	PTK2B	LPXN	-1.56448834155668	3.31565482735716e-09
THCA	PTK2B	FYN	1.53834998421964	4.21231598094427e-10
BLCA	PTK2B	TGFB1I1	-6.67169407753472	5.340576171875e-05
LUSC	PTK2B	TGFB1I1	-4.00345327898812	5.34377151276906e-06
STAD	PTK2B	SRC	1.29268590267835	6.0301274061203e-05
KICH	PTK2B	BCAR1	1.02588741679847	6.36577606201172e-05
BRCA	PTK2B	SRC	-1.01389608845799	7.35163663752073e-11
BRCA	PTK2B	PTPN11	-1.55172115438468	7.41985411816593e-10
BRCA	PTK2B	ITGB3	-2.31786489296506	7.43369260396519e-12
HNSC	PTK2B	TGFB1I1	-5.86127749320457	8.09852713246075e-05
LUAD	PTK2B	TGFB1I1	-4.04574794296636	8.47350536268894e-07
PRAD	PTK2B	TGFB1I1	-1.55365105794322	9.70835898507786e-08

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with PTK2B

TGFB1I1, CBL, SORBS2, GIT1, GSN, GRIN2A, DLG3, DLG4, PTPN6, SYK, LCK, FYN, PTK2B, JAK3, JAK1, IL7R, PXN, KCNA2, LYN, BCAR1, NEDD9, JAK2, EGFR, SRC, PITPNM3, PITPNM1, PITPNM2, SLC2A1, PRKCD, ASAP2, GNA13, LPXN, ITGB2, TLN1, NPHP1, PTPN12, ITGB3, PTPN11, GRB2, RB1CC1, EWSR1, VAV1, RASA1, ERBB2, SOCS3, MBD2, PTEN, SOCS2, SH3KBP1, PDCD6IP, ALG2, DNM1, GP6, GP1BB, TRAF4, SKAP2, UL49, MAPT, HSP90AA1, CBLB, ERBB3, NEDD4L, NEDD4, KIAA1429, PIK3R1, ITGB1, NCF1, GRM1,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
PTK2B	chr8	27277564	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PTK2B	chr8	27279881	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PTK2B	chr8	27279883	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PTK2B	chr8	27288514	C	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PTK2B	chr8	27291039	C	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PTK2B	chr8	27293306	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PTK2B	chr8	27297745	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
PTK2B	BLCA	chr8	27293865	27293865	C	T	Silent		9
PTK2B	LUAD	chr8	27312084	27312084	G	T	Missense_Mutation	p.V924L	7
PTK2B	BLCA	chr8	27255263	27255263	A	G	Silent		6
PTK2B	PAAD	chr8	27315813	27315813	C	T	Silent	p.I939I	6
PTK2B	STAD	chr8	27308338	27308338	C	T	Missense_Mutation	p.R805W	5
PTK2B	PAAD	chr8	27288476	27288476	C	T	Silent	p.F251F	5
PTK2B	CESC	chr8	27277537	27277537	G	A	Silent		5
PTK2B	KIRC	chr8	27301762	27301762	C	T	Missense_Mutation	p.L730F	5
PTK2B	BLCA	chr8	27255080	27255080	A	G	Missense_Mutation		5
PTK2B	BRCA	chr8	27293815	27293815	C	A	Missense_Mutation	p.L431I	5
PTK2B	HNSC	chr8	27310644	27310644	G	A	Silent	p.G854G	4
PTK2B	SKCM	chr8	27278190	27278190	C	T	Missense_Mutation	p.R134C	4
PTK2B	HNSC	chr8	27255128	27255128	T	C	Silent		4
PTK2B	CESC	chr8	27255146	27255146	G	A	Silent		4
PTK2B	HNSC	chr8	27310644	27310644	G	A	Silent		3
PTK2B	ESCA	chr8	27308400	27308400	G	T	Missense_Mutation		3
PTK2B	HNSC	chr8	27308585	27308585	A	C	Missense_Mutation		3
PTK2B	STAD	chr8	27301752	27301752	G	A	Silent	p.P726P	3
PTK2B	THYM	chr8	27312066	27312066	C	T	Missense_Mutation	p.R918W	3
PTK2B	SKCM	chr8	27289779	27289779	C	T	Silent	p.P296P	3
PTK2B	BRCA	chr8	27288485	27288485	C	T	Silent	p.L254	3
PTK2B	HNSC	chr8	27289833	27289833	G	A	Silent	p.E314E	3
PTK2B	UCEC	chr8	27308288	27308288	G	A	Missense_Mutation	p.S788N	3
PTK2B	BRCA	chr8	27296585	27296585	G	C	Missense_Mutation	p.E561Q	3
PTK2B	UCEC	chr8	27295365	27295365	G	A	Missense_Mutation	p.M537I	3
PTK2B	BRCA	chr8	27315867	27315867	G	A	Missense_Mutation	p.M957I	3
PTK2B	ESCA	chr8	27308400	27308400	G	T	Missense_Mutation	p.E825D	3
PTK2B	ESCA	chr8	27294938	27294938	G	A	Silent	p.P484P	2
PTK2B	SARC	chr8	27288893	27288893	G	T	Missense_Mutation	p.Q9H	2
PTK2B	UCEC	chr8	27277442	27277442	C	T	Missense_Mutation	p.R79W	2
PTK2B	LUAD	chr8	27289812	27289812	C	T	Silent	p.S307S	2
PTK2B	SKCM	chr8	27290975	27290975	C	T	Silent	p.S337S	2
PTK2B	BLCA	chr8	27301724	27301724	C	T	Splice_Site	p.P717L	2
PTK2B	SKCM	chr8	27297854	27297854	C	T	Silent	p.P645P	2
PTK2B	STAD	chr8	27279842	27279842	C	T	Missense_Mutation	p.R165C	2
PTK2B	UCEC	chr8	27296597	27296597	C	A	Missense_Mutation	p.L565M	2
PTK2B	LIHC	chr8	27277556	27277556	A	-	Frame_Shift_Del	p.K117fs	2
PTK2B	SKCM	chr8	27309058	27309058	C	T	Silent	p.F564F	2
PTK2B	STAD	chr8	27277438	27277438	C	T	Silent	p.S77S	2
PTK2B	UCEC	chr8	27277461	27277461	G	A	Missense_Mutation	p.R85Q	2
PTK2B	SKCM	chr8	27308398	27308398	G	A	Missense_Mutation	p.E825K	2
PTK2B	HNSC	chr8	27312077	27312077	C	T	Silent	p.I921I	2
PTK2B	PRAD	chr8	27310662	27310662	G	A	Silent	p.P860P	2
PTK2B	SKCM	chr8	27311673	27311673	C	T	Silent	p.S866S	2
PTK2B	ESCA	chr8	27294938	27294938	G	A	Silent		2
PTK2B	STAD	chr8	27300491	27300491	C	T	Silent	p.P713P	2
PTK2B	UCEC	chr8	27296913	27296913	T	C	Missense_Mutation	p.F611S	2
PTK2B	SKCM	chr8	27296616	27296616	C	T	Missense_Mutation	p.S571F	2
PTK2B	STAD	chr8	27297930	27297930	C	T	Missense_Mutation	p.R671C	2
PTK2B	UCEC	chr8	27277504	27277504	C	A	Silent	p.S99	2
PTK2B	LIHC	chr8	27315905	27315905	A	T	Missense_Mutation		2
PTK2B	SKCM	chr8	27279826	27279826	G	A	Silent	p.R159R	2
PTK2B	CESC	chr8	27277474	27277474	C	T	Silent		2
PTK2B	ESCA	chr8	27296648	27296648	G	T	Missense_Mutation		2
PTK2B	STAD	chr8	27278199	27278199	C	A	Missense_Mutation	p.P137T	2
PTK2B	UCEC	chr8	27297824	27297824	C	T	Silent	p.I635	2
PTK2B	LUAD	chr8	27255117	27255117	G	A	Missense_Mutation	p.E6K	2
PTK2B	BLCA	chr8	27297834	27297834	G	C	Missense_Mutation	p.E639Q	2
PTK2B	COAD	chr8	27310672	27310672	G	A	Missense_Mutation	p.A864T	2
PTK2B	SKCM	chr8	27296617	27296617	C	T	Silent	p.S571S	2
PTK2B	STAD	chr8	27289871	27289871	C	-	Frame_Shift_Del	p.A327fs	2
PTK2B	UCEC	chr8	27279872	27279872	G	A	Missense_Mutation	p.A175T	2
PTK2B	SKCM	chr8	27255255	27255255	C	T	Missense_Mutation	p.P52S	2
PTK2B	CESC	chr8	27296838	27296838	G	A	Missense_Mutation		2
PTK2B	STAD	chr8	27297913	27297913	A	G	Missense_Mutation	p.D665G	2
PTK2B	UCEC	chr8	27297846	27297846	C	T	Missense_Mutation	p.R643W	2
PTK2B	SKCM	chr8	27301771	27301771	C	T	Missense_Mutation	p.P733S	2
PTK2B	COAD	chr8	27311779	27311779	C	-	Frame_Shift_Del	p.L901fs	2
PTK2B	UCEC	chr8	27287616	27287616	C	T	Silent	p.F186	2
PTK2B	UCEC	chr8	27300451	27300451	G	A	Missense_Mutation	p.R700Q	2
PTK2B	LUAD	chr8	27287917	27287917	G	A	Silent	p.Q217Q	2
PTK2B	STAD	chr8	27293788	27293788	C	T	Missense_Mutation	p.R422C	2
PTK2B	STAD	chr8	27311752	27311752	G	A	Missense_Mutation		2
PTK2B	LIHC	chr8	27288457	27288457	A	G	Missense_Mutation		2
PTK2B	BLCA	chr8	27277583	27277583	G	A	Missense_Mutation	p.E126K	2
PTK2B	STAD	chr8	27296915	27296915	G	A	Missense_Mutation	p.A612T	2
PTK2B	UCEC	chr8	27288437	27288437	C	T	Silent	p.Y238	2
PTK2B	UCEC	chr8	27308361	27308361	G	A	Silent	p.Q812	2
PTK2B	LUAD	chr8	27295394	27295394	A	C	Missense_Mutation	p.H547P	2
PTK2B	CESC	chr8	27279825	27279825	G	A	Missense_Mutation		2
PTK2B	ESCA	chr8	27290985	27290985	G	T	Missense_Mutation		2
PTK2B	THCA	chr8	27294958	27294958	G	A	Missense_Mutation	p.G491D	2
PTK2B	SKCM	chr8	27311744	27311744	C	T	Missense_Mutation	p.A890V	2
PTK2B	SKCM	chr8	27288406	27288406	G	A	Missense_Mutation	p.R228Q	2
PTK2B	STAD	chr8	27303434	27303434	C	T	Missense_Mutation	p.R780W	2
PTK2B	UCEC	chr8	27288924	27288924	A	G	Missense_Mutation	p.N274D	2
PTK2B	LIHC	chr8	27315905	27315905	A	T	Missense_Mutation	p.E970V	2
PTK2B	UCEC	chr8	27309038	27309038	C	T	Missense_Mutation	p.R558C	2
PTK2B	CESC	chr8	27294966	27294966	G	A	Missense_Mutation		2
PTK2B	THCA	chr8	27291612	27291612	G	A	Missense_Mutation	p.G370S	2
PTK2B	LIHC	chr8	27293843	27293843	A	G	Missense_Mutation		2
PTK2B	SKCM	chr8	27278210	27278210	C	T	Silent	p.F140F	2
PTK2B	SKCM	chr8	27296843	27296843	C	T	Missense_Mutation	p.P588S	2
PTK2B	ESCA	chr8	27290985	27290985	G	T	Missense_Mutation	p.A341S	2
PTK2B	STAD	chr8	27293800	27293800	G	A	Missense_Mutation	p.V426I	2
PTK2B	UCEC	chr8	27289827	27289827	G	A	Silent	p.P312	2
PTK2B	LIHC	chr8	27293843	27293843	A	G	Missense_Mutation	p.Y440C	2
PTK2B	UCEC	chr8	27311788	27311788	G	A	Missense_Mutation	p.G905S	2
PTK2B	STAD	chr8	27308338	27308338	C	T	Missense_Mutation		2
PTK2B	SKCM	chr8	27290974	27290974	C	T	Missense_Mutation	p.S337F	2
PTK2B	COAD	chr8	27297910	27297910	A	G	Missense_Mutation	p.Y664C	2
PTK2B	PAAD	chr8	27315813	27315813	C	T	Silent		2
PTK2B	SKCM	chr8	27287662	27287662	G	A	Missense_Mutation	p.E202K	2
PTK2B	UCEC	chr8	27291044	27291044	C	A	Silent	p.G360	2
PTK2B	LUAD	chr8	27277480	27277480	G	T	Silent	p.G91G	2
PTK2B	STAD	chr8	27303311	27303311	G	A	Missense_Mutation		2
PTK2B	THYM	chr8	27297833	27297833	G	T	Silent		2
PTK2B	PAAD	chr8	27288476	27288476	C	T	Silent		2
PTK2B	SKCM	chr8	27296605	27296605	C	T	Silent	p.D567D	2
PTK2B	ESCA	chr8	27296648	27296648	G	T	Missense_Mutation	p.A582S	2
PTK2B	STAD	chr8	27287640	27287640	A	G	Silent	p.A194A	2
PTK2B	UCEC	chr8	27293270	27293270	C	T	Silent	p.I401	2
PTK2B	HNSC	chr8	27295006	27295006	A	G	Missense_Mutation	p.Y507C	2
PTK2B	LUAD	chr8	27277505	27277505	G	T	Missense_Mutation	p.D100Y	2
PTK2B	UCEC	chr8	27255303	27255303	C	T	Missense_Mutation	p.R68W	2
PTK2B	SKCM	chr8	27288404	27288404	C	T	Silent	p.F227F	2
PTK2B	SKCM	chr8	27295002	27295002	C	T	Missense_Mutation	p.P506S	2
PTK2B	STAD	chr8	27288462	27288462	G	A	Missense_Mutation	p.V247I	2
PTK2B	UCEC	chr8	27296578	27296578	C	A	Silent	p.A558	2
PTK2B	HNSC	chr8	27311740	27311740	C	T	Missense_Mutation	p.R889W	2
PTK2B	LGG	chr8	27288419	27288419	G	A	Silent	p.Q232Q	1
PTK2B	LUAD	chr8	27294637	27294637	A	C	Splice_Site		1
PTK2B	CESC	chr8	27296867	27296868	-	C	Frame_Shift_Ins	p.I597fs	1
PTK2B	SKCM	chr8	27294653	27294653	C	T	Silent	p.I452I	1
PTK2B	TGCT	chr8	27308264	27308266	AGG	-	Splice_Site		1
PTK2B	THYM	chr8	27297768	27297768	G	T	Nonsense_Mutation	p.E617X	1
PTK2B	LIHC	chr8	27300454	27300454	C	-	Frame_Shift_Del		1
PTK2B	COAD	chr8	27303389	27303389	A	G	Missense_Mutation	p.T765A	1
PTK2B	SKCM	chr8	27300482	27300482	C	T	Silent	p.F710F	1
PTK2B	HNSC	chr8	27291621	27291621	C	T	Missense_Mutation	p.R373W	1
PTK2B	ESCA	chr8	27296648	27296648	G	T	Splice_Site	p.A582_splice	1
PTK2B	LGG	chr8	27287914	27287914	G	A	Silent		1
PTK2B	LUAD	chr8	27295350	27295350	G	C	Missense_Mutation	p.Q532H	1
PTK2B	SARC	chr8	27296914	27296914	C	T	Splice_Site	p.F611_splice	1
PTK2B	BLCA	chr8	27301724	27301724	C	T	Missense_Mutation		1
PTK2B	COAD	chr8	27277537	27277537	G	A	Silent	p.T110T	1
PTK2B	TGCT	chr8	27301725	27301725	C	G	Silent		1
PTK2B	BLCA	chr8	27294682	27294682	A	G	Missense_Mutation	p.D462G	1
PTK2B	COAD	chr8	27308399	27308399	A	G	Missense_Mutation	p.E825G	1
PTK2B	LIHC	chr8	27309111	27309111	A	G	Missense_Mutation		1
PTK2B	LUSC	chr8	27315846	27315846	G	T	Silent	p.L950L	1
PTK2B	LIHC	chr8	27279892	27279892	G	-	Frame_Shift_Del	p.L181fs	1
PTK2B	CESC	chr8	27309052	27309052	G	T	Silent		1
PTK2B	SKCM	chr8	27301764	27301764	C	T	Silent	p.L730L	1
PTK2B	THYM	chr8	27310632	27310632	G	A	Silent	p.L850L	1
PTK2B	ESCA	chr8	27277410	27277412	AGG	-	Splice_Site	p.R68_splice	1
PTK2B	LGG	chr8	27288419	27288419	G	A	Silent		1
PTK2B	LUAD	chr8	27308291	27308291	G	T	Missense_Mutation	p.S789I	1
PTK2B	SARC	chr8	27309048	27309048	C	T	Missense_Mutation	p.S561L	1
PTK2B	BLCA	chr8	27294682	27294682	A	G	Missense_Mutation		1
PTK2B	COAD	chr8	27288442	27288442	C	T	Missense_Mutation	p.S240L	1
PTK2B	TGCT	chr8	27308264	27308266	AGG	-	Splice_Site	p.R780_splice	1
PTK2B	BLCA	chr8	27255210	27255210	G	T	Missense_Mutation	p.D37Y	1
PTK2B	COAD	chr8	27310638	27310638	C	A	Missense_Mutation	p.F852L	1
PTK2B	HNSC	chr8	27311740	27311740	C	T	Missense_Mutation		1
PTK2B	MESO	chr8	27289784	27289784	G	T	Missense_Mutation		1
PTK2B	HNSC	chr8	27278228	27278228	G	A	Silent	p.E146E	1
PTK2B	LIHC	chr8	27294975	27294975	C	-	Frame_Shift_Del	p.P497fs	1
PTK2B	READ	chr8	27277503	27277503	C	T	Missense_Mutation	p.S99F	1
PTK2B	SKCM	chr8	27289797	27289797	C	T	Silent	p.F302F	1
PTK2B	THYM	chr8	27297833	27297833	G	T	Silent	p.L638L	1
PTK2B	GBM	chr8	27301729	27301729	C	T	Nonsense_Mutation	p.R719*	1
PTK2B	LGG	chr8	27308398	27308398	G	T	Nonsense_Mutation		1
PTK2B	SARC	chr8	27296914	27296914	C	T	Silent		1
PTK2B	BLCA	chr8	27255210	27255210	G	T	Missense_Mutation		1
PTK2B	COAD	chr8	27288488	27288488	C	T	Silent	p.A255A	1
PTK2B	SKCM	chr8	27293863	27293863	C	T	Missense_Mutation	p.H447Y	1
PTK2B	THCA	chr8	27294958	27294958	G	A	Missense_Mutation		1
PTK2B	HNSC	chr8	27289833	27289833	G	A	Silent		1
PTK2B	LIHC	chr8	27315938	27315938	A	G	Missense_Mutation	p.H981R	1
PTK2B	MESO	chr8	27295383	27295383	C	A	Silent		1
PTK2B	LIHC	chr8	27311779	27311779	C	-	Frame_Shift_Del	p.P903fs	1
PTK2B	SARC	chr8	27309048	27309048	C	T	Missense_Mutation		1
PTK2B	ESCA	chr8	27277410	27277412	AGG	-	Splice_Site		1
PTK2B	SKCM	chr8	27255116	27255116	C	T	Silent	p.S5S	1
PTK2B	THCA	chr8	27291612	27291612	G	A	Missense_Mutation		1
PTK2B	THYM	chr8	27287619	27287619	C	T	Silent	p.F187F	1
PTK2B	GBM	chr8	27296903	27296903	G	A	Missense_Mutation	p.V608I	1
PTK2B	LGG	chr8	27292057	27292057	C	A	Silent		1
PTK2B	LUAD	chr8	27288392	27288392	G	T	Splice_Site		1
PTK2B	SARC	chr8	27296914	27296914	C	T	Silent	p.F611	1
PTK2B	COAD	chr8	27288527	27288527	A	T	Missense_Mutation	p.E268D	1
PTK2B	SKCM	chr8	27297773	27297773	C	T	Silent	p.I618I	1
PTK2B	OV	chr8	27349753	27349753	G	C	Missense_Mutation		1
PTK2B	BLCA	chr8	27303425	27303425	C	A	Missense_Mutation	p.H777N	1
PTK2B	SKCM	chr8	27297912	27297912	G	A	Missense_Mutation	p.D665N	1
PTK2B	HNSC	chr8	27278228	27278228	G	A	Silent		1
PTK2B	LIHC	chr8	27294711	27294711	A	G	Missense_Mutation	p.M472V	1
PTK2B	KIRC	chr8	27296898	27296898	G	A	Missense_Mutation	p.S606N	1
PTK2B	LIHC	chr8	27309049	27309049	G	-	Frame_Shift_Del	p.S561fs	1
PTK2B	SARC	chr8	27288490	27288490	G	T	Missense_Mutation		1
PTK2B	CESC	chr8	27291063	27291070	AGGAAAGG	-	Splice_Site		1
PTK2B	ESCA	chr8	27288779	27288779	G	T	Missense_Mutation		1
PTK2B	SKCM	chr8	27303314	27303314	C	T	Missense_Mutation	p.P740S	1
PTK2B	THCA	chr8	27309049	27309049	G	T	Silent		1
PTK2B	GBM	chr8	27308400	27308400	G	A	Silent	p.E825E	1
PTK2B	LUAD	chr8	27288520	27288520	G	A	Translation_Start_Site		1
PTK2B	SARC	chr8	27297937	27297937	C	T	Missense_Mutation	p.T673I	1
PTK2B	COAD	chr8	27292073	27292073	A	T	Missense_Mutation	p.I397L	1
PTK2B	OV	chr8	27303406	27303406	G	T	Silent	p.R770R	1
PTK2B	COAD	chr8	27296585	27296585	G	T	Nonsense_Mutation	p.E561X	1
PTK2B	SKCM	chr8	27296837	27296837	C	T	Missense_Mutation	p.R586C	1
PTK2B	HNSC	chr8	27312077	27312077	C	T	Silent		1
PTK2B	LIHC	chr8	27255270	27255270	A	T	Nonsense_Mutation	p.K57X	1
PTK2B	KIRP	chr8	27315863	27315863	A	T	Missense_Mutation	p.K956M	1
PTK2B	LIHC	chr8	27279873	27279873	C	-	Frame_Shift_Del	p.A175fs	1
PTK2B	SARC	chr8	27288968	27288968	G	T	Missense_Mutation		1
PTK2B	SKCM	chr8	27255260	27255260	G	A	Silent	p.G53G	1
PTK2B	STAD	chr8	27311752	27311752	G	A	Missense_Mutation	p.E893K	1
PTK2B	STAD	chr8	27291017	27291023	CTGCCGG	-	Frame_Shift_Del		1
PTK2B	THYM	chr8	27309027	27309027	G	T	Missense_Mutation	p.R554L	1
PTK2B	GBM	chr8	27310672	27310672	G	A	Missense_Mutation		1
PTK2B	LIHC	chr8	27292036	27292036	G	-	Frame_Shift_Del		1
PTK2B	LUAD	chr8	27311715	27311715	G	T	Silent	p.V880V	1
PTK2B	BLCA	chr8	27297834	27297834	G	C	Missense_Mutation		1
PTK2B	COAD	chr8	27293827	27293827	T	-	Frame_Shift_Del	p.G434fs	1
PTK2B	OV	chr8	27333386	27333386	G	C	Missense_Mutation	p.E88Q	1
PTK2B	ESCA	chr8	27277410	27277412	AGG	-	Splice_Site	e2-1	1
PTK2B	SKCM	chr8	27295003	27295003	C	T	Missense_Mutation	p.P506L	1
PTK2B	KIRP	chr8	27289836	27289836	G	T	Missense_Mutation		1
PTK2B	LIHC	chr8	27287903	27287903	T	-	Frame_Shift_Del	p.F214fs	1
PTK2B	LUAD	chr8	27296831	27296831	G	T	Missense_Mutation	p.V584L	1
PTK2B	SARC	chr8	27297857	27297857	G	T	Missense_Mutation		1
PTK2B	SKCM	chr8	27289790	27289790	C	T	Missense_Mutation	p.A300V	1
PTK2B	STAD	chr8	27303311	27303311	G	A	Splice_Site	p.V739_splice	1
PTK2B	STAD	chr8	27277438	27277438	C	T	Silent		1
PTK2B	UCEC	chr8	27308361	27308361	G	A	Silent	p.Q812Q	1
PTK2B	GBM	chr8	27296903	27296903	G	A	Missense_Mutation		1
PTK2B	LUAD	chr8	27296911	27296911	G	T	Missense_Mutation	p.M610I	1
PTK2B	BLCA	chr8	27303425	27303425	C	A	Missense_Mutation		1
PTK2B	COAD	chr8	27297899	27297899	C	T	Silent	p.R660R	1
PTK2B	OV	chr8	27311036	27311036	G	T	Missense_Mutation	p.E6D	1
PTK2B	SKCM	chr8	27288464	27288464	C	T	Silent	p.V247V	1
PTK2B	LGG	chr8	27279865	27279865	G	A	Silent	p.E172E	1
PTK2B	LIHC	chr8	27255270	27255270	A	T	Nonsense_Mutation		1
PTK2B	SARC	chr8	27288893	27288893	G	T	Missense_Mutation		1
PTK2B	CESC	chr8	27310671	27310671	C	T	Silent		1
PTK2B	SKCM	chr8	27294993	27294993	G	A	Missense_Mutation	p.E503K	1
PTK2B	STAD	chr8	27297938	27297938	C	T	Silent	p.T673T	1
PTK2B	THYM	chr8	27301752	27301752	G	T	Silent		1
PTK2B	HNSC	chr8	27291621	27291621	C	T	Missense_Mutation		1
PTK2B	LIHC	chr8	27311779	27311779	C	-	Frame_Shift_Del		1
PTK2B	LUAD	chr8	27296909	27296909	A	T	Missense_Mutation	p.M610L	1
PTK2B	BLCA	chr8	27277583	27277583	G	A	Missense_Mutation		1
PTK2B	ESCA	chr8	27294938	27294938	G	A	Silent	p.P484	1
PTK2B	SKCM	chr8	27308328	27308328	G	A	Silent	p.K801K	1
PTK2B	STAD	chr8	27308396	27308398	AGG	-	In_Frame_Del	p.824_824del	1
PTK2B	HNSC	chr8	27277505	27277505	G	A	Missense_Mutation	p.D100N	1
PTK2B	LIHC	chr8	27255270	27255270	A	T	Nonsense_Mutation	p.K57*	1
PTK2B	LGG	chr8	27279873	27279873	C	T	Missense_Mutation	p.A175V	1
PTK2B	SARC	chr8	27297937	27297937	C	T	Missense_Mutation		1
PTK2B	BLCA	chr8	27255125	27255125	G	A	Silent		1
PTK2B	CESC	chr8	27279825	27279825	G	A	Missense_Mutation	p.R159Q	1
PTK2B	SKCM	chr8	27312122	27312122	G	A	Silent	p.R936R	1
PTK2B	STAD	chr8	27255114	27255114	T	A	Missense_Mutation	p.S5T	1
PTK2B	HNSC	chr8	27277505	27277505	G	A	Missense_Mutation		1
PTK2B	LIHC	chr8	27288935	27288935	G	A	Silent		1
PTK2B	LUAD	chr8	27303405	27303405	G	T	Missense_Mutation	p.R770L	1
PTK2B	BLCA	chr8	27255125	27255125	G	A	Silent	p.L8L	1
PTK2B	COAD	chr8	27300395	27300395	C	T	Silent	p.D681D	1
PTK2B	SKCM	chr8	27309061	27309061	C	T	Silent	p.L565L	1
PTK2B	LIHC	chr8	27287902	27287903	-	T	Frame_Shift_Ins	p.FF212fs	1
PTK2B	LGG	chr8	27287914	27287914	G	A	Silent	p.K216K	1
PTK2B	SARC	chr8	27255173	27255173	G	T	Missense_Mutation		1
PTK2B	BLCA	chr8	27294953	27294953	G	A	Silent		1
PTK2B	CESC	chr8	27294966	27294966	G	A	Missense_Mutation	p.E494K	1
PTK2B	SKCM	chr8	27295362	27295362	C	T	Silent	p.A536A	1
PTK2B	STAD	chr8	27308396	27308398	AGG	-	In_Frame_Del	p.E826del	1
PTK2B	STAD	chr8	27303311	27303311	G	A	Missense_Mutation	p.V739I	1
PTK2B	THYM	chr8	27287619	27287619	C	T	Silent		1
PTK2B	LIHC	chr8	27293867	27293867	T	A	Splice_Site		1
PTK2B	LUAD	chr8	27291057	27291057	C	T	Missense_Mutation	p.H365Y	1
PTK2B	BLCA	chr8	27294953	27294953	G	A	Silent	p.L489L	1
PTK2B	COAD	chr8	27301725	27301725	C	G	Silent	p.P717P	1
PTK2B	SKCM	chr8	27301785	27301785	C	T	Silent	p.F737F	1
PTK2B	LIHC	chr8	27310644	27310645	-	C	Frame_Shift_Ins	p.GP854fs	1

Copy number variation (CNV) of PTK2B
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across PTK2B
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
70025	N/A	BM151262	CASC3	chr17	38305566	+	PTK2B	chr8	27316903	-
70025	N/A	AW859660	CDCA4	chr14	105482575	+	PTK2B	chr8	27202136	+
70025	PRAD	TCGA-HC-7818-01A	DCAF5	chr14	69619482	-	PTK2B	chr8	27169821	+
70025	BLCA	TCGA-HQ-A2OE	EPHX2	chr8	27375589	+	PTK2B	chr8	27308265	+
70025	BLCA	TCGA-HQ-A2OE-01A	EPHX2	chr8	27375589	+	PTK2B	chr8	27308266	+
70025	COAD	TCGA-A6-2677-01A	ESCO2	chr8	27641574	+	PTK2B	chr8	27255065	+
70025	N/A	EC543446	FAM177A1	chr14	35533412	+	PTK2B	chr8	27305161	+
70025	N/A	BF854692	MALAT1	chr11	65266788	+	PTK2B	chr8	27202389	+
70025	N/A	AA713524	PKM	chr15	72491784	+	PTK2B	chr8	27293799	-
96847	N/A	M87916	PTK2B	chr8	27276299	+	ETFA	chr15	76522855	-
103056	BRCA	TCGA-A7-A26I-01B	PTK2B	chr8	27183198	+	GNAS	chr20	57470667	+
80857	SKCM	TCGA-EE-A3JI-06A	PTK2B	chr8	27277590	+	ICA1L	chr2	203693739	-
70026	N/A	AA559336	PTK2B	chr8	27169987	-	PTK2B	chr8	27170050	+
103181	TGCT	TCGA-YU-A94I-01A	PTK2B	chr8	27183198	+	SLC5A1	chr22	32462922	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRC	PTK2B	0.0146289353880399	0.41
LUAD	PTK2B	0.0190048706440869	0.51
BLCA	PTK2B	0.0196894158710378	0.51
COAD	PTK2B	0.0238434359035393	0.6
LAML	PTK2B	0.0412109897601007	0.99
THCA	PTK2B	0.0419894203272092	0.99

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	PTK2B	0.00823708401340737	0.26
KICH	PTK2B	0.0142051279261038	0.43
LGG	PTK2B	0.0238290614027881	0.67
OV	PTK2B	0.0283979946299439	0.77
ESCA	PTK2B	0.0105273808052784	0.33
THYM	PTK2B	0.000165737197323174	0.0055
CHOL	PTK2B	0.0225396696449111	0.65

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
Q14289	DB01097	Leflunomide	Antagonist	Small molecule	Approved\|Investigational
Q14289	DB08341	4-{[4-{[(1R,2R)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-N-methylbenzenesulfonamide		Small molecule	Experimental
Q14289	DB11817	Baricitinib	Inhibitor	Small molecule	Approved\|Investigational
Q14289	DB01097	Leflunomide	Antagonist
Q14289	DB08341	4-{[4-{[(1R,2R)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-N-methylbenzenesulfonamide
Q14289	DB11817	Baricitinib	Inhibitor

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0001973	Alcoholic Intoxication, Chronic	1	PSYGENET
C0007114	Malignant neoplasm of skin	1	CTD_human
C0025202	melanoma	1	CTD_human
C0038220	Status Epilepticus	1	CTD_human
C0270823	Petit mal status	1	CTD_human
C0311335	Grand Mal Status Epilepticus	1	CTD_human
C0393734	Complex Partial Status Epilepticus	1	CTD_human
C0751522	Status Epilepticus, Subclinical	1	CTD_human
C0751523	Non-Convulsive Status Epilepticus	1	CTD_human