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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: MTIF3 (NCBI Gene ID:219402)

Gene Summary

Gene Summary

Gene Information	Gene Name: MTIF3
	Gene ID: 219402
	Gene Symbol	MTIF3
	Gene ID	219402
	Gene Name	mitochondrial translational initiation factor 3
	Synonyms	IF3mt
	Cytomap	13q12.2
	Type of Gene	protein-coding
	Description	translation initiation factor IF-3, mitochondrialIF-3(Mt)
	Modification date	20200320
	UniProtAcc	Q9H2K0

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0032543	Mitochondrial translation
GO:0008135	Translation factor activity, RNA binding
GO:0006413	Translational initiation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MTIF3	GO:0032790	ribosome disassembly	12095986
Hgene	MTIF3	GO:0070124	mitochondrial translational initiation	12095986

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
MTIF3	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'MTIF3[title] AND translation [title] AND human.'

Gene	Title	PMID
MTIF3	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000381116	28011252	28011410	Frame-shift
ENST00000381120	28011252	28011410	Frame-shift
ENST00000405591	28011252	28011410	Frame-shift
ENST00000381116	28014125	28014586	3UTR-3CDS
ENST00000381120	28014125	28014586	3UTR-3CDS
ENST00000405591	28014125	28014586	3UTR-3CDS
ENST00000381116	28015153	28015214	3UTR-3UTR
ENST00000381120	28019224	28019293	3UTR-3UTR
ENST00000405591	28019224	28019293	3UTR-3UTR
ENST00000381116	28023988	28024055	3UTR-3UTR

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
COAD	MTIF3	1.61088953830673	0.00561287999153138
STAD	MTIF3	-1.25397254610668	0.0093395933508873
BRCA	MTIF3	-1.57382804516009	4.69602801583771e-07
LUSC	MTIF3	1.14980970601281	5.67568378344708e-05

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
THYM	MTIF3	3	2	0.0379320092467806	0.617803773584906	0.559109931506849	0.725890998166755	0.627944086820266

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
DLBC	MTIF3	0.049395742	0.01245078

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with MTIF3 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	Epifactor	MTIF3	SAP18	0.83597062	8.92E-13
DLBC	Cell metabolism gene	MTIF3	PFDN5	0.840599397	7.79E-14
DLBC	Cell metabolism gene	MTIF3	TOMM7	0.854857786	1.06E-14
PRAD	TF	MTIF3	GTF3A	0.804007608	8.12E-126
READ	Cell metabolism gene	MTIF3	POLR1D	0.808598588	1.81E-25
TGCT	TF	MTIF3	GTF3A	0.824591455	6.19E-40
THYM	Cell metabolism gene	MTIF3	SNRPB	0.800554608	1.86E-28
THYM	Cell metabolism gene	MTIF3	GALK1	0.801480242	1.45E-28
THYM	Cell metabolism gene	MTIF3	TAZ	0.802700827	1.04E-28
THYM	Cell metabolism gene	MTIF3	ACTB	0.805395887	4.98E-29
THYM	Cell metabolism gene	MTIF3	GUK1	0.805584329	4.72E-29
THYM	Cell metabolism gene	MTIF3	TIMM17B	0.808760655	1.95E-29
THYM	Cell metabolism gene	MTIF3	SNRPD1	0.809860954	1.43E-29
THYM	Cell metabolism gene	MTIF3	PSMA6	0.811722813	8.39E-30
THYM	Cell metabolism gene	MTIF3	PGP	0.814344388	3.93E-30
THYM	Cell metabolism gene	MTIF3	TIMM8B	0.814830656	3.41E-30
THYM	Cell metabolism gene	MTIF3	APRT	0.816777893	1.92E-30
THYM	Cell metabolism gene	MTIF3	ACOT8	0.817255334	1.67E-30
THYM	Cell metabolism gene	MTIF3	PSMC3	0.818265563	1.24E-30
THYM	Cell metabolism gene	MTIF3	LSM2	0.820488513	6.35E-31
THYM	Cell metabolism gene	MTIF3	ZNRD1	0.820588264	6.16E-31
THYM	Cell metabolism gene	MTIF3	NT5M	0.821355746	4.88E-31
THYM	Cell metabolism gene	MTIF3	POLR2J	0.825571333	1.33E-31
THYM	Cell metabolism gene	MTIF3	PFDN6	0.834385748	7.83E-33
THYM	Cell metabolism gene	MTIF3	PAFAH1B3	0.83580327	4.89E-33
THYM	Cell metabolism gene	MTIF3	EXOSC1	0.836169873	4.33E-33
THYM	Cell metabolism gene	MTIF3	PSMB7	0.839248566	1.53E-33
THYM	Cell metabolism gene	MTIF3	APOA1	0.840214176	1.10E-33
THYM	Cell metabolism gene	MTIF3	EBP	0.840696196	9.29E-34
THYM	Cell metabolism gene	MTIF3	SEC61G	0.841785901	6.37E-34
THYM	Cell metabolism gene	MTIF3	PSMB3	0.844288878	2.65E-34
THYM	Cell metabolism gene	MTIF3	SNRPD2	0.846700473	1.12E-34
THYM	Cell metabolism gene	MTIF3	PSMB10	0.850199667	3.12E-35
THYM	Cell metabolism gene	MTIF3	LSM3	0.852412567	1.37E-35
THYM	Cell metabolism gene	MTIF3	PSMD13	0.854255313	6.83E-36
THYM	Cell metabolism gene	MTIF3	SNRPF	0.859282041	9.72E-37
THYM	Cell metabolism gene	MTIF3	MTMR14	0.86134635	4.27E-37
THYM	Cell metabolism gene	MTIF3	PHKG2	0.86299563	2.19E-37
THYM	Cell metabolism gene	MTIF3	PSMA4	0.863409896	1.85E-37
THYM	Cell metabolism gene	MTIF3	DGUOK	0.868685568	2.05E-38
THYM	Cell metabolism gene	MTIF3	LSM4	0.871490274	6.13E-39
THYM	Cell metabolism gene	MTIF3	SEC61B	0.873127075	2.99E-39
THYM	Cell metabolism gene	MTIF3	LSM5	0.879164221	1.93E-40
THYM	Cell metabolism gene	MTIF3	TXN	0.882035073	4.99E-41
THYM	CGC	MTIF3	TFPT	0.817024517	1.79E-30
THYM	CGC	MTIF3	COX6C	0.820334531	6.65E-31
THYM	CGC	MTIF3	H3F3A	0.841437694	7.18E-34
THYM	Epifactor	MTIF3	SIRT6	0.801997983	1.26E-28
THYM	Epifactor	MTIF3	SIRT7	0.802178567	1.20E-28
THYM	Epifactor	MTIF3	PPM1G	0.805291593	5.12E-29
THYM	Epifactor	MTIF3	ACTB	0.805395887	4.98E-29
THYM	Epifactor	MTIF3	H2AFX	0.812899367	5.98E-30
THYM	Epifactor	MTIF3	RUVBL2	0.81559533	2.73E-30
THYM	Epifactor	MTIF3	TFPT	0.817024517	1.79E-30
THYM	Epifactor	MTIF3	HIST1H2BH	0.828066615	6.07E-32
THYM	Epifactor	MTIF3	PPP4C	0.8281036	6.00E-32
THYM	Epifactor	MTIF3	INO80E	0.828663294	5.02E-32
THYM	Epifactor	MTIF3	BRMS1	0.832946309	1.26E-32
THYM	Epifactor	MTIF3	PRMT7	0.83472205	7.01E-33
THYM	Epifactor	MTIF3	EXOSC1	0.836169873	4.33E-33
THYM	Epifactor	MTIF3	HIST1H2AJ	0.839225182	1.54E-33
THYM	Epifactor	MTIF3	H3F3A	0.841437694	7.18E-34
THYM	Epifactor	MTIF3	ZNHIT1	0.84249906	4.96E-34
THYM	Epifactor	MTIF3	RBX1	0.851321608	2.06E-35
THYM	Epifactor	MTIF3	HIST2H2AC	0.852139968	1.52E-35
THYM	Epifactor	MTIF3	TAF10	0.852360656	1.40E-35
THYM	Epifactor	MTIF3	CDK9	0.863761933	1.60E-37
THYM	Epifactor	MTIF3	SS18L2	0.870841019	8.13E-39
THYM	IUPHAR	MTIF3	CSNK2B	0.800771642	1.76E-28
THYM	IUPHAR	MTIF3	SIRT6	0.801997983	1.26E-28
THYM	IUPHAR	MTIF3	SIRT7	0.802178567	1.20E-28
THYM	IUPHAR	MTIF3	DYRK4	0.803290548	8.87E-29
THYM	IUPHAR	MTIF3	TOP1MT	0.8072661	2.96E-29
THYM	IUPHAR	MTIF3	NT5M	0.821355746	4.88E-31
THYM	IUPHAR	MTIF3	PRMT7	0.83472205	7.01E-33
THYM	IUPHAR	MTIF3	CTRL	0.847302506	9.00E-35
THYM	IUPHAR	MTIF3	PPIA	0.860468585	6.07E-37
THYM	IUPHAR	MTIF3	PHKG2	0.86299563	2.19E-37
THYM	IUPHAR	MTIF3	CDK9	0.863761933	1.60E-37
THYM	Kinase	MTIF3	DYRK4	0.803290548	8.87E-29
THYM	Kinase	MTIF3	PHKG2	0.86299563	2.19E-37
THYM	Kinase	MTIF3	CDK9	0.863761933	1.60E-37
THYM	TF	MTIF3	IRF3	0.802519611	1.09E-28
THYM	TF	MTIF3	ZNF653	0.806375078	3.79E-29
THYM	TF	MTIF3	MYPOP	0.810040488	1.36E-29
THYM	TF	MTIF3	ZNF688	0.811040376	1.02E-29
THYM	TF	MTIF3	PIN1	0.81461154	3.64E-30
THYM	TF	MTIF3	ETV2	0.823044311	2.91E-31
THYM	TF	MTIF3	RBCK1	0.831681095	1.90E-32
THYM	TF	MTIF3	ZNF394	0.835742815	4.99E-33
THYM	TF	MTIF3	DRAP1	0.85152757	1.91E-35
THYM	TF	MTIF3	MXD3	0.851870509	1.68E-35
THYM	TF	MTIF3	THYN1	0.87095852	7.73E-39
THYM	TF	MTIF3	ZNF444	0.883565003	2.39E-41
THYM	TF	MTIF3	GTF3A	0.912283325	2.39E-48
THYM	TSG	MTIF3	SIRT6	0.801997983	1.26E-28
THYM	TSG	MTIF3	IRF3	0.802519611	1.09E-28
THYM	TSG	MTIF3	GNB2L1	0.803090871	9.37E-29
THYM	TSG	MTIF3	AIF1	0.804625848	6.15E-29
THYM	TSG	MTIF3	H2AFX	0.812899367	5.98E-30
THYM	TSG	MTIF3	PIN1	0.81461154	3.64E-30
THYM	TSG	MTIF3	NPRL2	0.81564958	2.68E-30
THYM	TSG	MTIF3	PFN1	0.831120381	2.28E-32
THYM	TSG	MTIF3	BRMS1	0.832946309	1.26E-32
THYM	TSG	MTIF3	PLEKHO1	0.833122087	1.19E-32
THYM	TSG	MTIF3	AIP	0.844427313	2.52E-34
THYM	TSG	MTIF3	HTRA2	0.847698431	7.80E-35
UCS	Cell metabolism gene	MTIF3	SNRPB	0.800554608	1.86E-28
UCS	Cell metabolism gene	MTIF3	GALK1	0.801480242	1.45E-28
UCS	Cell metabolism gene	MTIF3	TAZ	0.802700827	1.04E-28
UCS	Cell metabolism gene	MTIF3	ACTB	0.805395887	4.98E-29
UCS	Cell metabolism gene	MTIF3	GUK1	0.805584329	4.72E-29
UCS	Cell metabolism gene	MTIF3	TIMM17B	0.808760655	1.95E-29
UCS	Cell metabolism gene	MTIF3	SNRPD1	0.809860954	1.43E-29
UCS	Cell metabolism gene	MTIF3	PSMA6	0.811722813	8.39E-30
UCS	Cell metabolism gene	MTIF3	PGP	0.814344388	3.93E-30
UCS	Cell metabolism gene	MTIF3	TIMM8B	0.814830656	3.41E-30
UCS	Cell metabolism gene	MTIF3	APRT	0.816777893	1.92E-30
UCS	Cell metabolism gene	MTIF3	ACOT8	0.817255334	1.67E-30
UCS	Cell metabolism gene	MTIF3	PSMC3	0.818265563	1.24E-30
UCS	Cell metabolism gene	MTIF3	LSM2	0.820488513	6.35E-31
UCS	Cell metabolism gene	MTIF3	ZNRD1	0.820588264	6.16E-31
UCS	Cell metabolism gene	MTIF3	NT5M	0.821355746	4.88E-31
UCS	Cell metabolism gene	MTIF3	POLR2J	0.825571333	1.33E-31
UCS	Cell metabolism gene	MTIF3	PFDN6	0.834385748	7.83E-33
UCS	Cell metabolism gene	MTIF3	PAFAH1B3	0.83580327	4.89E-33
UCS	Cell metabolism gene	MTIF3	EXOSC1	0.836169873	4.33E-33
UCS	Cell metabolism gene	MTIF3	PSMB7	0.839248566	1.53E-33
UCS	Cell metabolism gene	MTIF3	APOA1	0.840214176	1.10E-33
UCS	Cell metabolism gene	MTIF3	EBP	0.840696196	9.29E-34
UCS	Cell metabolism gene	MTIF3	SEC61G	0.841785901	6.37E-34
UCS	Cell metabolism gene	MTIF3	PSMB3	0.844288878	2.65E-34
UCS	Cell metabolism gene	MTIF3	SNRPD2	0.846700473	1.12E-34
UCS	Cell metabolism gene	MTIF3	PSMB10	0.850199667	3.12E-35
UCS	Cell metabolism gene	MTIF3	LSM3	0.852412567	1.37E-35
UCS	Cell metabolism gene	MTIF3	PSMD13	0.854255313	6.83E-36
UCS	Cell metabolism gene	MTIF3	SNRPF	0.859282041	9.72E-37
UCS	Cell metabolism gene	MTIF3	MTMR14	0.86134635	4.27E-37
UCS	Cell metabolism gene	MTIF3	PHKG2	0.86299563	2.19E-37
UCS	Cell metabolism gene	MTIF3	PSMA4	0.863409896	1.85E-37
UCS	Cell metabolism gene	MTIF3	DGUOK	0.868685568	2.05E-38
UCS	Cell metabolism gene	MTIF3	LSM4	0.871490274	6.13E-39
UCS	Cell metabolism gene	MTIF3	SEC61B	0.873127075	2.99E-39
UCS	Cell metabolism gene	MTIF3	LSM5	0.879164221	1.93E-40
UCS	Cell metabolism gene	MTIF3	TXN	0.882035073	4.99E-41
UCS	CGC	MTIF3	TFPT	0.817024517	1.79E-30
UCS	CGC	MTIF3	COX6C	0.820334531	6.65E-31
UCS	CGC	MTIF3	H3F3A	0.841437694	7.18E-34
UCS	Epifactor	MTIF3	SIRT6	0.801997983	1.26E-28
UCS	Epifactor	MTIF3	SIRT7	0.802178567	1.20E-28
UCS	Epifactor	MTIF3	PPM1G	0.805291593	5.12E-29
UCS	Epifactor	MTIF3	ACTB	0.805395887	4.98E-29
UCS	Epifactor	MTIF3	H2AFX	0.812899367	5.98E-30
UCS	Epifactor	MTIF3	RUVBL2	0.81559533	2.73E-30
UCS	Epifactor	MTIF3	TFPT	0.817024517	1.79E-30
UCS	Epifactor	MTIF3	HIST1H2BH	0.828066615	6.07E-32
UCS	Epifactor	MTIF3	PPP4C	0.8281036	6.00E-32
UCS	Epifactor	MTIF3	INO80E	0.828663294	5.02E-32
UCS	Epifactor	MTIF3	BRMS1	0.832946309	1.26E-32
UCS	Epifactor	MTIF3	PRMT7	0.83472205	7.01E-33
UCS	Epifactor	MTIF3	EXOSC1	0.836169873	4.33E-33
UCS	Epifactor	MTIF3	HIST1H2AJ	0.839225182	1.54E-33
UCS	Epifactor	MTIF3	H3F3A	0.841437694	7.18E-34
UCS	Epifactor	MTIF3	ZNHIT1	0.84249906	4.96E-34
UCS	Epifactor	MTIF3	RBX1	0.851321608	2.06E-35
UCS	Epifactor	MTIF3	HIST2H2AC	0.852139968	1.52E-35
UCS	Epifactor	MTIF3	TAF10	0.852360656	1.40E-35
UCS	Epifactor	MTIF3	CDK9	0.863761933	1.60E-37
UCS	Epifactor	MTIF3	SS18L2	0.870841019	8.13E-39
UCS	IUPHAR	MTIF3	CSNK2B	0.800771642	1.76E-28
UCS	IUPHAR	MTIF3	SIRT6	0.801997983	1.26E-28
UCS	IUPHAR	MTIF3	SIRT7	0.802178567	1.20E-28
UCS	IUPHAR	MTIF3	DYRK4	0.803290548	8.87E-29
UCS	IUPHAR	MTIF3	TOP1MT	0.8072661	2.96E-29
UCS	IUPHAR	MTIF3	NT5M	0.821355746	4.88E-31
UCS	IUPHAR	MTIF3	PRMT7	0.83472205	7.01E-33
UCS	IUPHAR	MTIF3	CTRL	0.847302506	9.00E-35
UCS	IUPHAR	MTIF3	PPIA	0.860468585	6.07E-37
UCS	IUPHAR	MTIF3	PHKG2	0.86299563	2.19E-37
UCS	IUPHAR	MTIF3	CDK9	0.863761933	1.60E-37
UCS	Kinase	MTIF3	DYRK4	0.803290548	8.87E-29
UCS	Kinase	MTIF3	PHKG2	0.86299563	2.19E-37
UCS	Kinase	MTIF3	CDK9	0.863761933	1.60E-37
UCS	TF	MTIF3	IRF3	0.802519611	1.09E-28
UCS	TF	MTIF3	ZNF653	0.806375078	3.79E-29
UCS	TF	MTIF3	MYPOP	0.810040488	1.36E-29
UCS	TF	MTIF3	ZNF688	0.811040376	1.02E-29
UCS	TF	MTIF3	PIN1	0.81461154	3.64E-30
UCS	TF	MTIF3	ETV2	0.823044311	2.91E-31
UCS	TF	MTIF3	RBCK1	0.831681095	1.90E-32
UCS	TF	MTIF3	ZNF394	0.835742815	4.99E-33
UCS	TF	MTIF3	DRAP1	0.85152757	1.91E-35
UCS	TF	MTIF3	MXD3	0.851870509	1.68E-35
UCS	TF	MTIF3	THYN1	0.87095852	7.73E-39
UCS	TF	MTIF3	ZNF444	0.883565003	2.39E-41
UCS	TF	MTIF3	GTF3A	0.912283325	2.39E-48
UCS	TSG	MTIF3	SIRT6	0.801997983	1.26E-28
UCS	TSG	MTIF3	IRF3	0.802519611	1.09E-28
UCS	TSG	MTIF3	GNB2L1	0.803090871	9.37E-29
UCS	TSG	MTIF3	AIF1	0.804625848	6.15E-29
UCS	TSG	MTIF3	H2AFX	0.812899367	5.98E-30
UCS	TSG	MTIF3	PIN1	0.81461154	3.64E-30
UCS	TSG	MTIF3	NPRL2	0.81564958	2.68E-30
UCS	TSG	MTIF3	PFN1	0.831120381	2.28E-32
UCS	TSG	MTIF3	BRMS1	0.832946309	1.26E-32
UCS	TSG	MTIF3	PLEKHO1	0.833122087	1.19E-32
UCS	TSG	MTIF3	AIP	0.844427313	2.52E-34
UCS	TSG	MTIF3	HTRA2	0.847698431	7.80E-35
UVM	Cell metabolism gene	MTIF3	NUPL2	0.825087444	4.96E-21
UVM	Cell metabolism gene	MTIF3	MED4	0.828955425	2.24E-21
UVM	Epifactor	MTIF3	HMGB1	0.821417916	1.04E-20
UVM	IUPHAR	MTIF3	MARK3	0.801880732	3.99E-19
UVM	IUPHAR	MTIF3	CYP2R1	0.805871249	1.96E-19
UVM	IUPHAR	MTIF3	CSNK1G3	0.818014722	2.02E-20
UVM	Kinase	MTIF3	MARK3	0.801880732	3.99E-19
UVM	Kinase	MTIF3	CSNK1G3	0.818014722	2.02E-20
UVM	TF	MTIF3	ZNF480	0.802929057	3.31E-19
UVM	TF	MTIF3	ZNF700	0.803487359	3.00E-19
UVM	TF	MTIF3	ZNF302	0.804471959	2.52E-19
UVM	TF	MTIF3	ZNF564	0.805484799	2.10E-19
UVM	TF	MTIF3	ZNF10	0.806302562	1.81E-19
UVM	TF	MTIF3	ZNF181	0.808906456	1.13E-19
UVM	TF	MTIF3	ZNF182	0.818255013	1.93E-20
UVM	TF	MTIF3	ZNF195	0.818449259	1.85E-20
UVM	TF	MTIF3	ZNF26	0.818510143	1.83E-20
UVM	TF	MTIF3	ZNF226	0.820545757	1.23E-20
UVM	TF	MTIF3	GPBP1	0.823112555	7.39E-21
UVM	TF	MTIF3	ZNF140	0.842292199	1.24E-22
UVM	TSG	MTIF3	PDCD5	0.808819785	1.14E-19

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
STAD	MTIF3	MTIF2	-1.91099017365555	0.000110303983092308
PRAD	MTIF3	MTIF2	-2.91163945232732	0.000148819683073472
BRCA	MTIF3	MRPS15	-2.19567551682318	0.000188684660674703
KICH	MTIF3	MRPS5	1.25108287838437	0.000249803066253662
THCA	MTIF3	MTIF2	1.01909960064239	0.00052377205169468
LIHC	MTIF3	MRPS7	1.27029395477208	0.00182077236082954
STAD	MTIF3	MRPS16	-1.64208084987431	0.00239070039242506
STAD	MTIF3	PTCD3	-1.34538483750672	0.00256496202200651
KIRC	MTIF3	MRPS15	1.11572283836012	0.00361818577801855
PRAD	MTIF3	MRPS9	1.04379115553269	0.00496210155254694
HNSC	MTIF3	MRPS16	-2.01564621821803	0.00518989327406416
CHOL	MTIF3	MRPS6	2.57097392409939	0.0078125
LUSC	MTIF3	MRPS6	-1.26158810839259	0.013873001943322
THCA	MTIF3	MRPS15	-1.19960602422995	0.0140154883942907
KIRC	MTIF3	MTIF2	-1.30575511475086	0.0182888755834972
ESCA	MTIF3	MRPS5	-2.15440118747854	0.0185546875
THCA	MTIF3	MRPS11	-3.10694728540962	0.0252226935182201
READ	MTIF3	PTCD3	2.94667594287193	0.03125
HNSC	MTIF3	PTCD3	1.11617967730562	0.0372559385364731
BLCA	MTIF3	MRPS11	-2.30276998968219	0.040130615234375
THCA	MTIF3	MRPS10	1.33413691764991	1.55171507174296e-05
LUAD	MTIF3	MRPS5	-2.20881945885927	1.77904381378076e-06
LUSC	MTIF3	MRPS9	-3.60637641031661	1.82498668910368e-07
LUAD	MTIF3	MRPS9	-1.32894454884901	1.98978698949574e-05
BRCA	MTIF3	MRPS11	-1.24304977976804	2.31302509538916e-07
LUSC	MTIF3	PTCD3	-2.41729475275087	3.25673250216465e-06
PRAD	MTIF3	MRPS6	1.00673230965164	3.48152859299693e-07
LUAD	MTIF3	MTIF2	-5.14356588709714	3.996080695583e-11
LUSC	MTIF3	MRPS5	-7.65956389962319	4.27210217182982e-06
THCA	MTIF3	PTCD3	1.09980719703362	4.34082003868401e-07
KIRC	MTIF3	MRPS6	-3.12621933743663	4.95376546353503e-10
LUSC	MTIF3	MRPS11	-2.9004097541444	5.43966600483641e-07
KICH	MTIF3	MRPS6	-1.34376231922276	7.49826431274414e-05
BRCA	MTIF3	MRPS7	-2.12787460270434	9.33194208595055e-10

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with MTIF3

PAXIP1, MAPK1, SIAH1, PEA15, FBXO7, TMEM176A, VEZT, FXYD3, FETUB, SCD, CABP7, CGRRF1, TMED8, CDS2, ZDHHC15, NDRG4, CDIPT, LAPTM4B, TMEM147, TMEM97, HTATIP2, TMEM109, SELK, UNC50, VAMP4, SERP1, PLP1, STATH, LDLR, TMEM128, TMEM254, TMEM243, STX6, CXCL9, MGST3, NAT8, THSD7B, TMEM218, SERP2, MS4A1, TSPAN33, ITGB2, CLDND2, ADCK3, BMP10, STARD4, CMTM5, ZNF202, STX3, TMEM42, HSFX1, JAGN1, BCL2L1, ORMDL3, CLEC7A, RPRM, TMEM11, THBD, C17orf62, TUFM, MRFAP1, SERTM1, YIPF6, EPGN, BRICD5, TUSC5, CYP4F2, COL4A5, APOD, VKORC1L1, CD47, LHFPL5, BPIFA1, TMEM239, PLN, CTXN3, SNX2, LAT, TMEM242, PRH1, LOC100507537, FXYD6-FXYD2, HSFX2, SPANXN2, ACAD9, ACAT1, ACOT1, ACOT2, AFG3L2, AK4, ALAS1, ANGEL2, ATP5B, ATP5D, ATPIF1, ATP5J2-PTCD1, ATP5F1, ATP5H, ATP5J, ATPAF1, BCS1L, C17orf80, CARS2, CLPX, COX4I1, CRYZ, CS, DAP3, DBT, DHX30, DLAT, DLST, ECHS1, ELAC2, ERAL1, ETFA, ETFB, FASTKD2, FASTKD5, FLAD1, GADD45GIP1, GATB, GATC, GLS, GLUD1, GRSF1, GTPBP10, GUF1, HADHA, HARS2, HINT2, HNRNPA3, HNRNPAB, HNRNPDL, HNRNPK, HNRNPL, HNRNPR, HNRNPUL1, HSDL2, IARS2, IBA57, KIAA0391, LARS2, LETM1, LRPPRC, MDH2, MGME1, MMAB, RNMTL1, MRPL1, MRPL10, MRPL12, MRPL13, MRPL14, MRPL15, MRPL16, MRPL17, MRPL18, MRPL19, MRPL2, MRPL20, MRPL21, MRPL22, MRPL23, MRPL24, MRPL27, MRPL28, MRPL3, MRPL30, MRPL37, MRPL38, MRPL39, MRPL4, MRPL40, MRPL41, MRPL42, MRPL43, MRPL44, MRPL45, MRPL46, MRPL47, MRPL48, MRPL49, MRPL50, MRPL51, MRPL52, MRPL53, MRPL55, ICT1, MRPL9, MRPS10, MRPS11, MRPS14, MRPS16, MRPS17, MRPS18A, MRPS18B, MRPS18C, MRPS2, MRPS21, MRPS22, MRPS23, MRPS24, MRPS25, MRPS26, MRPS27, MRPS28, MRPS30, MRPS31, MRPS33, MRPS34, MRPS35, MRPS36, MRPS5, MRPS6, MRPS7, MRPS9, MTERF3, MTIF2, MTPAP, NDUFA12, NDUFA2, NDUFA5, NDUFA6, NDUFA7, NDUFA9, NDUFAB1, NDUFAF2, NDUFAF4, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, NFS1, NIPSNAP1, NME4, NNT, OGDH, OXA1L, PAM16, PDE12, PDHA1, PDHB, PDK1, PDK3, PNPLA8, PNPT1, POLG, POLRMT, PPA2, PPIF, PTCD3, PYCR1, PYCR2, QRSL1, RBFA, RBMX, SHMT2, SLC30A9, SLIRP, STOML2, SUCLA2, SUPV3L1, SYNCRIP, TACO1, TEFM, TFAM, THEM4, THG1L, TIMM44, TRMT10C, TRMT5, TRMT61B, TRUB2, TSFM, C10orf2, VARS2, VWA8, WARS2, MRRF, SEMG2, SEMG1,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
MTIF3	chr13	28014173	T	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
MTIF3	KIRP	chr13	28014392	28014392	C	T	Missense_Mutation		4
MTIF3	PRAD	chr13	28014243	28014243	G	A	Nonsense_Mutation	p.R115*	4
MTIF3	HNSC	chr13	28014281	28014281	C	T	Missense_Mutation	p.R102Q	3
MTIF3	UCEC	chr13	28014332	28014332	C	T	Missense_Mutation	p.R85Q	3
MTIF3	TGCT	chr13	28014201	28014201	G	T	Missense_Mutation	p.Q129K	2
MTIF3	UCEC	chr13	28009825	28009825	A	G	Missense_Mutation	p.V275A	2
MTIF3	UCEC	chr13	28011374	28011374	T	G	Missense_Mutation	p.N166T	2
MTIF3	UCEC	chr13	28011398	28011398	C	A	Missense_Mutation	p.R158I	2
MTIF3	STAD	chr13	28014243	28014243	G	A	Nonsense_Mutation	p.R115X	2
MTIF3	UCEC	chr13	28014221	28014221	C	T	Missense_Mutation	p.S122N	2
MTIF3	LIHC	chr13	28011260	28011260	T	-	Frame_Shift_Del	p.N204fs	2
MTIF3	UCEC	chr13	28014344	28014344	T	G	Missense_Mutation	p.K81T	2
MTIF3	STAD	chr13	28014141	28014141	C	A	Missense_Mutation	p.A149S	2
MTIF3	LIHC	chr13	28011278	28011278	T	-	Frame_Shift_Del	p.N198fs	2
MTIF3	LIHC	chr13	28014305	28014305	C	-	Frame_Shift_Del	p.G94fs	2
MTIF3	SKCM	chr13	28011316	28011316	T	C	Silent	p.K185K	2
MTIF3	HNSC	chr13	28011271	28011271	G	A	Silent	p.D200D	2
MTIF3	LIHC	chr13	28014377	28014377	T	-	Frame_Shift_Del	p.K70fs	2
MTIF3	HNSC	chr13	28009980	28009980	G	C	Missense_Mutation	p.F223L	2
MTIF3	TGCT	chr13	28014201	28014201	G	T	Missense_Mutation		2
MTIF3	BLCA	chr13	28009853	28009853	C	G	Missense_Mutation	p.D266H	1
MTIF3	SKCM	chr13	28011285	28011288	CTTT	-	Frame_Shift_Del	p.195_196del	1
MTIF3	LIHC	chr13	28014316	28014316	A	-	Frame_Shift_Del	p.F90fs	1
MTIF3	COAD	chr13	28010023	28010025	ATC	-	In_Frame_Del	p.209_209del	1
MTIF3	SKCM	chr13	28014305	28014305	C	T	Missense_Mutation	p.G94D	1
MTIF3	LIHC	chr13	28014296	28014296	A	-	Frame_Shift_Del	p.L97fs	1
MTIF3	COAD	chr13	28014415	28014415	G	A	Silent	p.T57T	1
MTIF3	SKCM	chr13	28014306	28014306	C	T	Missense_Mutation	p.G94S	1
MTIF3	LGG	chr13	28009965	28009965	T	C	Silent	p.Q228Q	1
MTIF3	LUAD	chr13	28014490	28014490	T	A	Silent	p.T32T	1
MTIF3	COAD	chr13	28014493	28014493	C	A	Missense_Mutation	p.K31N	1
MTIF3	SKCM	chr13	28014234	28014234	G	A	Nonsense_Mutation	p.Q118*	1
MTIF3	LGG	chr13	28009965	28009965	T	C	Silent		1
MTIF3	LUAD	chr13	28014556	28014556	T	C	Silent	p.T10T	1
MTIF3	GBM	chr13	28011394	28011394	C	A	Missense_Mutation		1
MTIF3	SKCM	chr13	28011285	28011288	CTTT	-	Frame_Shift_Del	p.KG195fs	1
MTIF3	LIHC	chr13	28009851	28009851	G	A	Silent		1
MTIF3	LUSC	chr13	28011400	28011400	C	G	Silent	p.L157L	1
MTIF3	HNSC	chr13	28011271	28011271	G	A	Silent		1
MTIF3	LIHC	chr13	28014368	28014369	-	T	Frame_Shift_Ins	p.S73fs	1
MTIF3	LUSC	chr13	28014513	28014513	C	A	Missense_Mutation	p.G25C	1
MTIF3	HNSC	chr13	28009980	28009980	G	C	Missense_Mutation		1
MTIF3	STAD	chr13	28014376	28014377	-	T	Frame_Shift_Ins	p.K70fs	1
MTIF3	BLCA	chr13	28010009	28010009	G	A	Missense_Mutation		1
MTIF3	OV	chr13	28011388	28011388	C	A	Silent	p.L161L	1
MTIF3	HNSC	chr13	28014281	28014281	C	T	Missense_Mutation		1
MTIF3	BLCA	chr13	28009853	28009853	C	G	Missense_Mutation		1
MTIF3	HNSC	chr13	28014163	28014163	C	G	Missense_Mutation	p.Q141H	1
MTIF3	STAD	chr13	28014139	28014139	C	T	Silent	p.A149A	1
MTIF3	BLCA	chr13	28014539	28014539	G	A	Missense_Mutation	p.S16F	1
MTIF3	STAD	chr13	28014243	28014243	G	A	Nonsense_Mutation		1
MTIF3	BLCA	chr13	28010009	28010009	G	A	Missense_Mutation	p.L214F	1
MTIF3	SKCM	chr13	28014234	28014234	G	A	Nonsense_Mutation	p.Q118X	1
MTIF3	LIHC	chr13	28011313	28011313	T	-	Frame_Shift_Del	p.K186fs	1

Copy number variation (CNV) of MTIF3
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across MTIF3
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
101347	STAD	TCGA-D7-8576-01A	ELF1	chr13	41634974	-	MTIF3	chr13	28019274	-
101347	STAD	TCGA-D7-8576-01A	ELF1	chr13	41634974	-	MTIF3	chr13	28019293	-
101347	N/A	AI088920	GTF3A	chr13	28010030	+	MTIF3	chr13	28011253	+
89931	STAD	TCGA-BR-6566	MTIF3	chr13	28019224	-	ESD	chr13	47367579	-
101403	LUSC	TCGA-22-5481	MTIF3	chr13	28019224	-	GNAI3	chr1	110116358	+
81566	N/A	AI418700	MTIF3	chr13	28009570	-	GTF3A	chr13	28009329	-
93440	N/A	BC012756	MTIF3	chr13	28014244	+	MCM2	chr3	127318322	+
91238	N/A	DA280527	MTIF3	chr13	28019224	-	SSBP1	chr7	141438922	+
101347	BRCA	TCGA-A7-A0CE	UBL3	chr13	30423648	-	MTIF3	chr13	28019293	-
101347	BRCA	TCGA-A7-A0CE-01A	UBL3	chr13	30423649	-	MTIF3	chr13	28019293	-
101353	ESCA	TCGA-LN-A49K	ZMYM2	chr13	20580726	+	MTIF3	chr13	28010030	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LAML	MTIF3	0.00411081299507549	0.12
KIRP	MTIF3	0.00725685220920265	0.2
MESO	MTIF3	0.0193276916872378	0.5

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
TGCT	MTIF3	0.0102978939750418	0.31
LGG	MTIF3	0.00277675152739668	0.092
BRCA	MTIF3	0.0464829523912415	1
PAAD	MTIF3	0.0293961759064613	0.85
ESCA	MTIF3	0.00755441342755876	0.23
THYM	MTIF3	0.00388282936231287	0.12

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source