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Center for Computational Systems Medicine
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Gene Summary

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Translation studies in PubMed

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Exon Skipping Events

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Expression

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Expression Regulation

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Associated Genes

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Protein 3D Structure

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Protein-Protein Interaction

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Mutations

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Prognostic Analysis

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Gender Association

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Age Association

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Related Drugs

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Related Diseases

Translation Factor: MRPS27 (NCBI Gene ID:23107)


Gene Summary

check button Gene Summary
Gene InformationGene Name: MRPS27
Gene ID: 23107
Gene Symbol

MRPS27

Gene ID

23107

Gene Namemitochondrial ribosomal protein S27
SynonymsMRP-S27|S27mt
Cytomap

5q13.2

Type of Geneprotein-coding
Description28S ribosomal protein S27, mitochondrialmitochondrial 28S ribosomal protein S27mitochondrial small ribosomal subunit protein mS27
Modification date20200313
UniProtAcc

Q92552


check button Child GO biological process term(s) under GO:0006412
GO IDGO term
GO:0006417Regulation of translation
GO:0032543Mitochondrial translation
GO:0005840Ribosome
GO:0045727Positive regulation of translation
GO:0006412Translation


check button Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Inferred gene age of translation factor.
GeneInferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
MRPS27(733 - 1119.25]


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Translation Studies in PubMed

check button We searched PubMed using 'MRPS27[title] AND translation [title] AND human.'
GeneTitlePMID
MRPS27MRPS27 is a pentatricopeptide repeat domain protein required for the translation of mitochondrially encoded proteins22841715


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Exon Skipping Events

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.
all structure

check button Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ENSTExon skip start (DNA)Exon Skip end (DNA)ORF
ENST000002614137151950971519677In-frame
ENST000002614137152409271524195Frame-shift

check button Exon skipping position in the amino acid sequence.
ENSTExon skip start (DNA)Exon Skip end (DNA)Len(transcript seq)Exon skip start (mRNA)Exon Skip end (mRNA)Len(amino acid seq)Exon skip start (AA)Exon Skip end (AA)
ENST00000261413715195097151967728028781045414279335

check button Potentially (partially) lost protein functional features of UniProt.
UniProtAccExon skip start (AA)Exon Skip end (AA)Function feature start (AA)Function feature end (AA)Functional feature typeFunctional feature desc.
Q9255227933537414ChainID=PRO_0000087712;Note=28S ribosomal protein S27%2C mitochondrial
Q92552279335284284Natural variantID=VAR_047026;Note=Polymorphism%3B confirmed at protein level. G->D;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17488105,ECO:0000269|PubMed:9039502;Dbxref=dbSNP:rs3209157,PMID:17488105,PMID:9039502


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Expression


check buttonGene expression level across TCGA pancancer
all structure

check buttonGene expression level across GTEx pantissue
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check buttonExpression level of gene isoforms across TCGA pancancer
all structure

check buttonExpression level of gene isoforms across GTEx pantissue
all structure

check buttonCancer(tissue) type-specific expression level of Translation factor using z-score distriution
all structure

check buttonDifferential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)
all structure
Cancer typeTranslation factorFCadj.pval
BRCAMRPS27-2.13313928627760.000127527962379903
LUADMRPS27-2.464611208735992.13247131179291e-05


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Expression Regulation


check buttonTranslation factor expression regulation through miRNA binding
Cancer typeGenemiRNATargetScan binding score (Context++ score percentile)CoefficientPvalue


check buttonTranslation factor expression regulation through methylation in the promoter of Translation factor
all structure
Cancer typeGenemethyl group bmethyl group aDEG pvalavg methyl in bavg methyl in aavg exp in bavg exp in a

check buttonTranslation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)
all structure
Cancer typeGenemethyl group bmethyl group aDEG pvalavg methyl in bavg methyl in aavg exp in bavg exp in a

check buttonTranslation factor expression regulation through copy number variation of Translation factor
all structure
Cancer typeGeneCoefficientPvalue
SARCMRPS270.5622056330.002064582

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Associated Genes


check button Strongly correlated genes belong to cellular important gene groups with MRPS27 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)
Cancer typeGene groupTranslation factorCorrelated geneCoefficientPvalue


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Protein structure


check button Protein 3D structure
Visit iCn3D.


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Protein-Protein Interaction


check button Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))
all structure

check buttonOverlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))
all structure
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* Edge colors based on TCGA cancer types.

check button* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))
all structure
Cancer typeTranslation factorInteracting protein coding geneFCadj.pval
LIHCMRPS27MRPS31-1.075652322561630.000180054839259286
BRCAMRPS27MRPS15-2.195675516823180.000188684660674703
KICHMRPS27MRPS51.251082878384370.000249803066253662
LUSCMRPS27MRPS28-1.739460888645320.000778331171335384
KIRCMRPS27MRPS18B-1.089993480106740.00208385211535325
STADMRPS27MRPS16-1.642080849874310.00239070039242506
LUSCMRPS27MRPS21-1.067382108984510.00291962754379891
LUADMRPS27MRPS311.581409157004420.00351308111790755
KIRCMRPS27MRPS151.115722838360120.00361818577801855
HNSCMRPS27MRPS16-2.015646218218030.00518989327406416
LUADMRPS27MRPS28-1.305512073606840.00627490756378455
CHOLMRPS27MRPS18B-1.343419614730830.0078125
THCAMRPS27MRPS15-1.199606024229950.0140154883942907
KICHMRPS27MRPS31-1.441716135774950.0173123478889465
BLCAMRPS27MRPS18B-2.793162037050830.0180816650390625
ESCAMRPS27MRPS5-2.154401187478540.0185546875
LUADMRPS27MRPS18B-2.591326042841760.0228310323601027
COADMRPS27MRPS311.259306100836780.0253507494926453
STADMRPS27MRPS18B-2.187838450614950.0341199110262096
KIRPMRPS27MRPS21-1.889331025219320.0413399673998356
BLCAMRPS27MRPS31-1.749897165816380.0445594787597656
KICHMRPS27MRPS221.593457798849860.0451226830482483
BRCAMRPS27MRPS21-1.819757862910871.52500483244108e-06
THCAMRPS27MRPS101.334136917649911.55171507174296e-05
LUADMRPS27MRPS5-2.208819458859271.77904381378076e-06
LUADMRPS27MRPS21-2.128285416554244.20890892730867e-05
LUSCMRPS27MRPS5-7.659563899623194.27210217182982e-06
PRADMRPS27MRPS311.428780089783386.76861513404814e-05
THCAMRPS27MRPS31-1.557598099332116.91106419786075e-09
KIRCMRPS27MRPS31-4.325410042408659.31897250092369e-08


check button Protein-protein interactors with this translation factor (BIOGRID-3.4.160)
PPI interactors with MRPS27
HNRNPA1, KHDRBS2, CDK9, ICT1, HDGF, ELAVL1, CUL3, CUL1, COPS5, CAND1, GRK5, MRPS23, DAP3, ILF3, SMURF1, ESR2, C1QBP, YWHAQ, MRPL3, MRPL12, TARDBP, PARK2, RIOK2, GRSF1, AURKB, HAUS2, CEP76, TP53, NECAB2, MOV10, NXF1, BTRC, FBXW11, NOL12, RPL13, TRA2A, RPL6, RPS8, DNAJC1, LRRC15, TRMT10B, ZNF707, LUC7L, MRPS31, MRPS5, MRPS22, MRPS28, NTRK1, CENPA, HNRNPU, RPL10, TSNAX, THOC5, PHF8, THOC2, MYH7B, FBXO31, FERMT3, ZSCAN26, Cep131, Smc1a, Samhd1, Tmed2, Mis12, Ufl1, Tnpo1, ERBB3, ZNF746, C8orf82, NOA1, MRPS34, MRPS9, MRPS33, MRPS7, MRPS11, MRPS26, PTCD3, MRPS35, MRPS24, MRPS21, STRBP, MRPS15, MRPS10, MRPS14, MRPS18C, MRPS2, MRPS25, MRPS16, MRPS18B, METTL17, AURKAIP1, MAPKAP1, PPP2R2B, PRPF8, EFTUD2, RPTOR, LARP7, HEXIM1, MEPCE, SNAI1, RECQL4, HABP4, SERBP1, MB21D1, FBL, HIST1H3A, RPS6, MRM1, HSPD1, PDK1, TRMT61B, KIAA1429, RC3H1, RC3H2, PHB, NR2C2, TCF7L2, ALYREF, SNRNP70, PTPN3, ITFG1, nsp8, BIRC3, STAU1, NFX1, BRD7, TRIM28, PLEKHA4, PTEN, ZC3H18, GRB7, PTPRR, ESR1, IMMP2L, CELF1, IGF2BP2, XRN2, ZC3HAV1, MEX3B, PRRC2A, IGF2BP1, RBMS1, CIT, ANLN, CHMP4C, ECT2, KIF14, KIF23, ACAD9, AUH, C12orf65, C17orf80, C21orf33, C6orf203, MCUR1, CCDC90B, CHCHD1, CLPB, COX15, CRYZ, CS, DDX28, DHX30, EXD2, FASTKD2, FASTKD3, FASTKD5, GFM1, GFM2, HINT2, LONP1, LRPPRC, MCU, CCDC109B, MDH2, METTL15, MRPL11, MRPS12, MRRF, MTERF3, MTFMT, MTG1, MTG2, MTIF2, MTIF3, MTRF1, MTRF1L, NGRN, OTC, PMPCA, PMPCB, RMND1, RPUSD3, RPUSD4, SLC25A51, SLIRP, SSBP1, SURF1, TACO1, TBRG4, TEFM, TFAM, C19orf52, TMEM70, TRUB2, TSFM, TUFM, VWA8, MKI67, ORF4a, MAFB, NINL, Apc2, RBM39, NR3C1, DNAJC21, DNAJA3, DNAJC15, DNAJC19, DNAJC28, DNAJC4, HSCB, UFL1, DDRGK1, AARS2, COX4I1, COX8A, PDHA1, TRAP1, FZR1, WDR5, MRPS6, S100A2, PDGFB, RPL17, MRPL2, MRPS17, PRR3, H1FNT, SRSF3, YBX1, SUPV3L1, ZFR, CTCF, MRPL18, YBX3, SRSF6, HIST1H2AG, SRP14, LIN28A, RPS15, IGF2BP3, PRKRIR, APOBEC3D, EPDR1, SRSF7, NEIL1, KBTBD7, RBMS2, ERAL1, NOP16, ABT1, RPL4, MCAT, GNL2, RPL35, ZNF574, GAR1, GLTSCR2, FAM120A, HIST1H2AM, GADD45GIP1, ZC3H3, SNRNP48, RCHY1, KLF12, SOX15, SOX2, TLX2, TLX3, KLF15, KLF16, KLF4, TLX1, ZEB1,


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Mutations


check button Clinically associated variants from ClinVar.
GeneChrPositionRefSeqVarSeqRefSeeqVarTypePathogenicDiseaseVarInfo
MRPS27chr571519644TCsingle_nucleotide_variantBenignnot_providedSO:0001583|missense_variantSO:0001583|missense_variant
MRPS27chr571519675GAsingle_nucleotide_variantBenignnot_providedSO:0001819|synonymous_variantSO:0001819|synonymous_variant


check button nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.
all structure


check button SNVs and Indels
GeneCancer typeChromosomeStartEndRefSeeqMutSeqMutation typeAAchange# samples
MRPS27UCECchr57159347571593475GTMissense_Mutationp.S69Y5
MRPS27CHOLchr57151960571519605CTMissense_Mutation3
MRPS27CHOLchr57151960571519605CTMissense_Mutationp.D304N3
MRPS27LGGchr57151678271516782GAMissense_Mutationp.A400V3
MRPS27STADchr57152410671524106GASilent2
MRPS27BRCAchr57161601971616019CTMissense_Mutationp.M10I2
MRPS27LIHCchr57151959271519592TAMissense_Mutation2
MRPS27LUADchr57161601371616013CASilentp.L12L2
MRPS27STADchr57152414571524145TGMissense_Mutationp.K214N2
MRPS27CESCchr57152191071521910CGMissense_Mutation2
MRPS27LIHCchr57151959271519592TAMissense_Mutationp.Q308L2
MRPS27SKCMchr57152829471528294GASilentp.C189C2
MRPS27LIHCchr57159139271591392C-Frame_Shift_Delp.E84fs2
MRPS27SKCMchr57152835071528350CTMissense_Mutationp.E171K2
MRPS27SKCMchr57151674071516740GCMissense_Mutationp.A414G2
MRPS27SKCMchr57153393771533937GASilentp.N100N2
MRPS27UCECchr57151697671516976CASplice_Sitee11-12
MRPS27SKCMchr57153392571533925CTSilentp.L104L2
MRPS27UCECchr57152835471528354CTMissense_Mutationp.M169I2
MRPS27LGGchr57159352071593520GCMissense_Mutation2
MRPS27UCECchr57152997271529972GTMissense_Mutationp.S150Y2
MRPS27COADchr57159346371593463GAMissense_Mutationp.S73L1
MRPS27SARCchr57151954571519545GTMissense_Mutation1
MRPS27LGGchr57151678271516782GAMissense_Mutation1
MRPS27LUADchr57153389371533893TAMissense_Mutationp.Q115L1
MRPS27ESCAchr57152829371528293GTMissense_Mutationp.L204M1
MRPS27SARCchr57151966871519668GTMissense_Mutationp.L283M1
MRPS27STADchr57152410671524106GASilentp.G227G1
MRPS27CESCchr57152416371524163ATSilent1
MRPS27ESCAchr57161620871616208GTRNANULL1
MRPS27SARCchr57151954571519545GTMissense_Mutationp.Q324K1
MRPS27LIHCchr57152834471528344AGMissense_Mutation1
MRPS27LUADchr57159346071593460CTMissense_Mutationp.R74Q1
MRPS27ESCAchr57152829371528293GTMissense_Mutation1
MRPS27SARCchr57151966871519668GTMissense_Mutation1
MRPS27LIHCchr57151966571519665CTMissense_Mutationp.G284S1
MRPS27STADchr57152189371521893AGSilentp.C276C1
MRPS27CESCchr57159346971593469GTMissense_Mutation1
MRPS27LUSCchr57152196871521968CTNonsense_Mutationp.W265*1
MRPS27GBMchr57161625271616252CGMissense_Mutation1
MRPS27SARCchr57161609671616096GARNANULL1
MRPS27STADchr57153395071533950CTMissense_Mutationp.R96Q1
MRPS27CESCchr57151965471519654CCSilent1
MRPS27PAADchr57153392671533926AGMissense_Mutationp.L104P1
MRPS27GBMchr57151691571516915TCMissense_Mutation1
MRPS27CESCchr57152191071521910CGMissense_Mutationp.E285Q1
MRPS27PRADchr57152402871524028TCSilentp.S197S1
MRPS27THCAchr57151966471519664CTMissense_Mutation1
MRPS27HNSCchr57151951271519512TCMissense_Mutation1
MRPS27LIHCchr57152202571522025C-Splice_Sitep.G232_splice1
MRPS27READchr57151689471516894TGMissense_Mutationp.K363Q1
MRPS27LGGchr57159352071593520GCMissense_Mutationp.A54G1
MRPS27BLCAchr57151687371516873CGMissense_Mutation1
MRPS27LIHCchr57152414571524145T-Frame_Shift_Delp.K214fs1
MRPS27READchr57152995671529956TGMissense_Mutationp.E155D1
MRPS27BLCAchr57153000671530006GCMissense_Mutation1
MRPS27LIHCchr57152836671528366A-Frame_Shift_Delp.F165fs1
MRPS27COADchr57151966471519664CTMissense_Mutationp.G284D1
MRPS27SARCchr57161607271616072GTMissense_Mutation1
MRPS27LGGchr57152829371528293GTMissense_Mutationp.L190M1
MRPS27BLCAchr57151687371516873CGMissense_Mutationp.E370Q1
MRPS27LIHCchr57152995471529954T-Frame_Shift_Delp.N156fs1
MRPS27COADchr57152416371524163ATSilentp.L208L1
MRPS27SARCchr57152994671529946CAMissense_Mutation1
MRPS27SKCMchr57151953371519533GAMissense_Mutationp.P328S1
MRPS27BLCAchr57153000671530006GCMissense_Mutationp.P139A1
MRPS27LUADchr57151959071519590CAMissense_Mutationp.G309W1

check buttonCopy number variation (CNV) of MRPS27
* Click on the image to open the original image in a new window.
all structure

check buttonFusion gene breakpoints (product of the structural variants (SVs)) across MRPS27
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


check button Fusion genes with this translation factor from FusionGDB2.0.
FusionGDB2 IDDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
84220Non-CancerTCGA-BR-6453-11AERGIC1chr5172261436+MRPS27chr571533955-
84220LUADTCGA-49-4514-01AMAST4chr566396420-MRPS27chr571516975-
102281STADTCGA-HU-8244-01AMRPS27chr571516880-CALM2chr247389700-
80273OVTCGA-20-1684MRPS27chr571609907-GNAI2chr350289531+
55184PRADTCGA-EJ-5516-01AMRPS27chr571609908-HIST1H2BNchr627809342+
84220N/ABI763814MRPS27chr571528331+MRPS27chr571528292-
55184N/ABE773233MRPS27chr571265804-PPP1R26-AS1chr9138356462-
84220N/AAK310474RNF217chr6125330430+MRPS27chr571533957-
84226N/AEC566261SMOC2chr6168981233+MRPS27chr571519566-


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Prognostic Analysis


check button Kaplan-Meier plots with logrank tests of overall survival (OS)
all structure
Cancer typeTranslation factorCoefficentHazard ratioWald test pvalLikelihool ratio pvalLogrank test pval# samples


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Translation factor and Gender


check button Differential gene expression between female and male. (Wilcoxon test, pval<0.05)
all structure
Cancer typeTranslation factorpvaladj.p
KIRCMRPS270.003452854589688960.097
SARCMRPS270.01836811573547950.5
LIHCMRPS270.0226777090698180.59
READMRPS270.02798325442821390.7

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Translation factor and Age


check button Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)
all structure
Cancer typeTranslation factorpvaladj.p
THCAMRPS270.001382806245253930.044
KIRCMRPS270.0001196662960463750.0039
LAMLMRPS270.02483671101399670.73
BRCAMRPS270.02176399941833190.67
PAADMRPS270.02430779035768670.73

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Related Drugs


check button Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)
UniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases


check button Diseases associated with this translation factor.
(DisGeNet 4.0)
Disease IDDisease Name# PubMedsDisease source