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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: LARP4B (NCBI Gene ID:23185)

Gene Summary

Gene Summary

Gene Information	Gene Name: LARP4B
	Gene ID: 23185
	Gene Symbol	LARP4B
	Gene ID	23185
	Gene Name	La ribonucleoprotein 4B
	Synonyms	KIAA0217\|LARP5
	Cytomap	10p15.3
	Type of Gene	protein-coding
	Description	la-related protein 4BLa ribonucleoprotein domain family member 4BLa ribonucleoprotein domain family, member 5la-related protein 5
	Modification date	20200313
	UniProtAcc	Q92615

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0005840	Ribosome
GO:0045727	Positive regulation of translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene

Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25

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Translation Studies in PubMed

We searched PubMed using 'LARP4B[title] AND translation [title] AND human.'

Gene	Title	PMID
LARP4B	LARP4B is an AU-rich sequence associated factor that promotes mRNA accumulation and translation	26001795

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000316157	860681	860790	Frame-shift
ENST00000316157	863664	863829	In-frame
ENST00000316157	871004	871256	In-frame
ENST00000316157	876806	876917	In-frame
ENST00000316157	890916	890995	Frame-shift
ENST00000316157	909682	909823	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000316157	863664	863829	5657	1572	1736	738	510	565
ENST00000316157	871004	871256	5657	1274	1525	738	411	494
ENST00000316157	876806	876917	5657	792	902	738	250	287
ENST00000316157	909682	909823	5657	331	471	738	96	143

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
Q92615	96	143	1	738	Chain	ID=PRO_0000281139;Note=La-related protein 4B
Q92615	250	287	1	738	Chain	ID=PRO_0000281139;Note=La-related protein 4B
Q92615	510	565	1	738	Chain	ID=PRO_0000281139;Note=La-related protein 4B
Q92615	411	494	1	738	Chain	ID=PRO_0000281139;Note=La-related protein 4B
Q92615	250	287	240	307	Domain	Note=RRM
Q92615	411	494	419	419	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:24129315;Dbxref=PMID:24129315
Q92615	411	494	424	424	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:19690332;Dbxref=PMID:18669648,PMID:19690332
Q92615	411	494	434	434	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:16964243,ECO:0000244\|PubMed:18669648;Dbxref=PMID:16964243,PMID:18669648
Q92615	411	494	451	451	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
Q92615	411	494	488	488	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
Q92615	411	494	493	493	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q6A0A2
Q92615	510	565	518	518	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:19690332;Dbxref=PMID:19690332
Q92615	510	565	524	524	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:19690332,ECO:0000244\|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:23186163
Q92615	510	565	556	556	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
LUAD	LARP4B	-1.4276334914994	0.000895454784300369
HNSC	LARP4B	-2.06292171686389	0.00459462782941955
COAD	LARP4B	1.2962162174147	0.00561287999153138
THCA	LARP4B	-3.20436871472883	2.19889745410215e-07
KIRC	LARP4B	1.26026213830679	3.74686018928209e-07
PRAD	LARP4B	1.85942326214296	5.63081519642993e-06

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
KICH	LARP4B	hsa-miR-145-5p	84	0.326801363193768	0.00342968732476397
LIHC	LARP4B	hsa-miR-29c-3p	92	-0.351201430148799	0.00184235000580501
OV	LARP4B	hsa-miR-145-5p	84	0.304362673952019	0.0286554304740348

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type

Gene

Coefficient

Pvalue

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with LARP4B (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	CGC	LARP4B	TPM3	0.815927667	8.59E-12
CHOL	TSG	LARP4B	GTPBP4	0.862080668	2.82E-14
OV	TSG	LARP4B	GTPBP4	0.81526702	1.40E-74
UVM	Cell metabolism gene	LARP4B	SEH1L	0.803716747	2.88E-19
UVM	Cell metabolism gene	LARP4B	PSMA4	0.803816385	2.83E-19
UVM	Cell metabolism gene	LARP4B	UPF2	0.805845357	1.97E-19
UVM	Cell metabolism gene	LARP4B	DIS3	0.810613888	8.22E-20
UVM	Cell metabolism gene	LARP4B	ALG13	0.817746142	2.13E-20
UVM	Cell metabolism gene	LARP4B	GPD2	0.818595447	1.80E-20
UVM	Cell metabolism gene	LARP4B	AUH	0.818897792	1.70E-20
UVM	Cell metabolism gene	LARP4B	XPO1	0.823477618	6.86E-21
UVM	Cell metabolism gene	LARP4B	PITPNB	0.824301702	5.82E-21
UVM	Cell metabolism gene	LARP4B	PIK3C3	0.830032357	1.79E-21
UVM	Cell metabolism gene	LARP4B	NUP50	0.830610293	1.59E-21
UVM	Cell metabolism gene	LARP4B	PSME4	0.83753468	3.58E-22
UVM	Cell metabolism gene	LARP4B	PIK3C2A	0.840478056	1.86E-22
UVM	Cell metabolism gene	LARP4B	TGS1	0.8424322	1.20E-22
UVM	Cell metabolism gene	LARP4B	VAPA	0.848516988	2.91E-23
UVM	CGC	LARP4B	ZMYM2	0.801917171	3.96E-19
UVM	CGC	LARP4B	BCLAF1	0.80236816	3.66E-19
UVM	CGC	LARP4B	FIP1L1	0.802644833	3.49E-19
UVM	CGC	LARP4B	CUL3	0.808725419	1.16E-19
UVM	CGC	LARP4B	RAD21	0.810181661	8.90E-20
UVM	CGC	LARP4B	PMS1	0.810720106	8.06E-20
UVM	CGC	LARP4B	BAZ1A	0.817836597	2.09E-20
UVM	CGC	LARP4B	UBR5	0.820464052	1.25E-20
UVM	CGC	LARP4B	USP8	0.820617001	1.21E-20
UVM	CGC	LARP4B	XPO1	0.823477618	6.86E-21
UVM	CGC	LARP4B	PWWP2A	0.823556087	6.76E-21
UVM	CGC	LARP4B	FBXO11	0.825846513	4.25E-21
UVM	CGC	LARP4B	TRIM24	0.827752364	2.88E-21
UVM	CGC	LARP4B	ATM	0.83768746	3.46E-22
UVM	CGC	LARP4B	BMPR1A	0.839563122	2.29E-22
UVM	CGC	LARP4B	ARID2	0.861378649	1.18E-24
UVM	CGC	LARP4B	TCF12	0.868871161	1.57E-25
UVM	Epifactor	LARP4B	ZMYM2	0.801917171	3.96E-19
UVM	Epifactor	LARP4B	SUDS3	0.802681121	3.46E-19
UVM	Epifactor	LARP4B	ACTR6	0.80438819	2.56E-19
UVM	Epifactor	LARP4B	WAC	0.805674643	2.03E-19
UVM	Epifactor	LARP4B	TDG	0.805841312	1.97E-19
UVM	Epifactor	LARP4B	TLK2	0.80691651	1.62E-19
UVM	Epifactor	LARP4B	CUL2	0.807052238	1.58E-19
UVM	Epifactor	LARP4B	ATAD2B	0.807131238	1.56E-19
UVM	Epifactor	LARP4B	CUL3	0.808725419	1.16E-19
UVM	Epifactor	LARP4B	NIPBL	0.810115357	9.01E-20
UVM	Epifactor	LARP4B	BRCC3	0.814325974	4.09E-20
UVM	Epifactor	LARP4B	TLK1	0.81444945	4.00E-20
UVM	Epifactor	LARP4B	SMEK1	0.816523124	2.69E-20
UVM	Epifactor	LARP4B	BAZ1A	0.817836597	2.09E-20
UVM	Epifactor	LARP4B	SMEK2	0.818087692	1.99E-20
UVM	Epifactor	LARP4B	UBR5	0.820464052	1.25E-20
UVM	Epifactor	LARP4B	TAF7	0.821297065	1.06E-20
UVM	Epifactor	LARP4B	CIR1	0.821298035	1.06E-20
UVM	Epifactor	LARP4B	CDK17	0.82131252	1.06E-20
UVM	Epifactor	LARP4B	TRIM24	0.827752364	2.88E-21
UVM	Epifactor	LARP4B	TAF5	0.831886307	1.21E-21
UVM	Epifactor	LARP4B	TAF2	0.832124409	1.15E-21
UVM	Epifactor	LARP4B	PHF20L1	0.837082507	3.96E-22
UVM	Epifactor	LARP4B	ATM	0.83768746	3.46E-22
UVM	Epifactor	LARP4B	MSL1	0.84624311	4.97E-23
UVM	Epifactor	LARP4B	JMJD1C	0.84884925	2.69E-23
UVM	Epifactor	LARP4B	AEBP2	0.857281399	3.39E-24
UVM	Epifactor	LARP4B	MASTL	0.857629817	3.10E-24
UVM	Epifactor	LARP4B	ARID2	0.861378649	1.18E-24
UVM	Epifactor	LARP4B	SMARCA5	0.862244554	9.41E-25
UVM	Epifactor	LARP4B	LEO1	0.867606126	2.23E-25
UVM	IUPHAR	LARP4B	MAP4K3	0.804921603	2.32E-19
UVM	IUPHAR	LARP4B	PLK4	0.805330557	2.16E-19
UVM	IUPHAR	LARP4B	TLK2	0.80691651	1.62E-19
UVM	IUPHAR	LARP4B	ATAD2B	0.807131238	1.56E-19
UVM	IUPHAR	LARP4B	TLK1	0.81444945	4.00E-20
UVM	IUPHAR	LARP4B	CDK13	0.815036505	3.58E-20
UVM	IUPHAR	LARP4B	BAZ1A	0.817836597	2.09E-20
UVM	IUPHAR	LARP4B	IDE	0.81913499	1.62E-20
UVM	IUPHAR	LARP4B	USP14	0.8196614	1.46E-20
UVM	IUPHAR	LARP4B	MARK3	0.820456304	1.25E-20
UVM	IUPHAR	LARP4B	CDK17	0.82131252	1.06E-20
UVM	IUPHAR	LARP4B	XPO1	0.823477618	6.86E-21
UVM	IUPHAR	LARP4B	FBXO11	0.825846513	4.25E-21
UVM	IUPHAR	LARP4B	ATP6V0A2	0.826893	3.43E-21
UVM	IUPHAR	LARP4B	TRIM24	0.827752364	2.88E-21
UVM	IUPHAR	LARP4B	PIK3C3	0.830032357	1.79E-21
UVM	IUPHAR	LARP4B	ADAM17	0.832703842	1.02E-21
UVM	IUPHAR	LARP4B	XIAP	0.834776868	6.53E-22
UVM	IUPHAR	LARP4B	STK3	0.835142865	6.04E-22
UVM	IUPHAR	LARP4B	ATP2B1	0.836735661	4.27E-22
UVM	IUPHAR	LARP4B	ATM	0.83768746	3.46E-22
UVM	IUPHAR	LARP4B	BMPR1A	0.839563122	2.29E-22
UVM	IUPHAR	LARP4B	PIK3C2A	0.840478056	1.86E-22
UVM	IUPHAR	LARP4B	VRK2	0.848837321	2.70E-23
UVM	IUPHAR	LARP4B	JMJD1C	0.84884925	2.69E-23
UVM	IUPHAR	LARP4B	ABCB10	0.855900067	4.80E-24
UVM	IUPHAR	LARP4B	TAOK3	0.856242421	4.41E-24
UVM	IUPHAR	LARP4B	MASTL	0.857629817	3.10E-24
UVM	Kinase	LARP4B	MAP4K3	0.804921603	2.32E-19
UVM	Kinase	LARP4B	PLK4	0.805330557	2.16E-19
UVM	Kinase	LARP4B	TLK2	0.80691651	1.62E-19
UVM	Kinase	LARP4B	TLK1	0.81444945	4.00E-20
UVM	Kinase	LARP4B	CDK13	0.815036505	3.58E-20
UVM	Kinase	LARP4B	BAZ1A	0.817836597	2.09E-20
UVM	Kinase	LARP4B	MARK3	0.820456304	1.25E-20
UVM	Kinase	LARP4B	CDK17	0.82131252	1.06E-20
UVM	Kinase	LARP4B	TRIM24	0.827752364	2.88E-21
UVM	Kinase	LARP4B	STK3	0.835142865	6.04E-22
UVM	Kinase	LARP4B	ATM	0.83768746	3.46E-22
UVM	Kinase	LARP4B	BMPR1A	0.839563122	2.29E-22
UVM	Kinase	LARP4B	VRK2	0.848837321	2.70E-23
UVM	Kinase	LARP4B	TAOK3	0.856242421	4.41E-24
UVM	Kinase	LARP4B	MASTL	0.857629817	3.10E-24
UVM	TF	LARP4B	ZNF397	0.800834439	4.80E-19
UVM	TF	LARP4B	ZNF181	0.801815757	4.04E-19
UVM	TF	LARP4B	IKZF5	0.803373931	3.06E-19
UVM	TF	LARP4B	ZNF800	0.803753835	2.86E-19
UVM	TF	LARP4B	ZNF572	0.803776253	2.85E-19
UVM	TF	LARP4B	ZBTB1	0.804604754	2.46E-19
UVM	TF	LARP4B	ZNF546	0.805296911	2.17E-19
UVM	TF	LARP4B	ZBTB6	0.805864905	1.96E-19
UVM	TF	LARP4B	ELF2	0.80708284	1.57E-19
UVM	TF	LARP4B	ZNF430	0.807792335	1.38E-19
UVM	TF	LARP4B	ZNF43	0.809713543	9.71E-20
UVM	TF	LARP4B	CEBPZ	0.810753746	8.01E-20
UVM	TF	LARP4B	MEF2A	0.813395778	4.88E-20
UVM	TF	LARP4B	CREBZF	0.81558186	3.22E-20
UVM	TF	LARP4B	AHCTF1	0.817865231	2.08E-20
UVM	TF	LARP4B	ZNF236	0.825942469	4.17E-21
UVM	TF	LARP4B	ADNP2	0.826578742	3.66E-21
UVM	TF	LARP4B	PURB	0.836702882	4.30E-22
UVM	TF	LARP4B	ZNF33A	0.839626442	2.25E-22
UVM	TF	LARP4B	PRDM10	0.84353093	9.32E-23
UVM	TF	LARP4B	TERF1	0.849947895	2.07E-23
UVM	TF	LARP4B	AEBP2	0.857281399	3.39E-24
UVM	TF	LARP4B	ARID2	0.861378649	1.18E-24
UVM	TF	LARP4B	ZNF75D	0.866783499	2.79E-25
UVM	TF	LARP4B	TCF12	0.868871161	1.57E-25
UVM	TSG	LARP4B	APAF1	0.803037372	3.25E-19
UVM	TSG	LARP4B	CUL2	0.807052238	1.58E-19
UVM	TSG	LARP4B	MLH3	0.808197034	1.28E-19
UVM	TSG	LARP4B	PPP2R5C	0.812671353	5.60E-20
UVM	TSG	LARP4B	GTPBP4	0.813898471	4.44E-20
UVM	TSG	LARP4B	RINT1	0.825655	4.42E-21
UVM	TSG	LARP4B	INTS6	0.826843204	3.47E-21
UVM	TSG	LARP4B	TRIM24	0.827752364	2.88E-21
UVM	TSG	LARP4B	CCAR1	0.834351901	7.16E-22
UVM	TSG	LARP4B	ATM	0.83768746	3.46E-22
UVM	TSG	LARP4B	BMPR1A	0.839563122	2.29E-22
UVM	TSG	LARP4B	SMCHD1	0.841365892	1.52E-22
UVM	TSG	LARP4B	GGNBP2	0.847592342	3.62E-23
UVM	TSG	LARP4B	PDS5B	0.860029995	1.68E-24
UVM	TSG	LARP4B	ARID2	0.861378649	1.18E-24

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
STAD	LARP4B	DHX9	-1.35515869279777	0.00016188295558095
HNSC	LARP4B	ABCF1	1.65276366009707	0.000163285275220915
BLCA	LARP4B	DHX9	2.25372387794619	0.00026702880859375
LIHC	LARP4B	RPL8	-4.84588284974558	0.00110314154326131
LUAD	LARP4B	GNB2L1	-2.23706676970836	0.00121089428940613
COAD	LARP4B	RPL32	2.10930675863764	0.00322914123535157
CHOL	LARP4B	PABPC1	-4.56272528815353	0.00390625
STAD	LARP4B	RPL32	2.08355685326952	0.00879816571250558
THCA	LARP4B	RPL31	1.09436372419291	0.0152379297688856
BLCA	LARP4B	PABPC1	1.31485302792746	0.0180816650390625
PRAD	LARP4B	RPL32	1.36027364301933	0.0190254949499432
PRAD	LARP4B	RPL31	1.37417394483053	0.0209655998648434
LIHC	LARP4B	PABPC1	-1.72076961362188	2.98009622125841e-06
KIRC	LARP4B	ABCF1	1.45583052554166	3.45880777969452e-10
KIRP	LARP4B	RPL32	-1.10565812377306	4.39747236669064e-05
KICH	LARP4B	ABCF1	1.057677872938	5.38825988769531e-05
KIRC	LARP4B	RPL8	-1.18252459971773	5.64962994208288e-07
KIRP	LARP4B	RPL8	-1.53003692350119	6.0301274061203e-05
KIRC	LARP4B	RPL11	-5.47536848868151	6.13619476098216e-10
BRCA	LARP4B	ABCF1	-1.96271473208125	6.43196487985321e-12
PRAD	LARP4B	GNB2L1	2.22079570419983	6.51372327512043e-05
PRAD	LARP4B	PABPC1	-2.10200318363476	8.55379952759014e-07

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with LARP4B

GNB2L1, ELAVL1, SIRT7, CUL3, COPS5, CDV3, HSP90AA1, MMS19, CDK18, HECW2, LIN28A, FHL3, RBFOX2, NTRK1, IFI16, XPO1, NPM1, RPL10, STRAP, Eif3a, Gspt1, Pabpc1, Rpl35, Hnrnpf, Cenpe, FAM136A, ASB3, IL13RA2, TRIM25, HBP1, ESR2, EZH2, RECQL4, RC3H1, RC3H2, PHB, ZC3H7A, HDAC2, IRF2, OASL, SNRNP70, nsp12, LMBR1L, NFX1, BRD7, MAGED1, ATXN1L, PLEKHA4, nsp9, nsp1, ESR1, C1QTNF9, CAPRIN1, CELF1, CPEB4, CSDE1, DAZL, DDX3X, FAM120C, FUBP3, FXR1, FXR2, G3BP1, IGF2BP1, IGF2BP2, ALG13, ANKHD1, ANKRD17, ATXN2, DDX1, DEPDC1B, FAM98A, G3BP2, HELZ, LARP1B, LARP4, MOV10, MTDH, OTUD4, PABPC1, PABPC4, PRRC2C, RPS3A, SECISBP2, SERBP1, SND1, SYNCRIP, TDRD3, TOP3B, UBAP2, UBAP2L, UPF1, USP10, YTHDF2, MEX3B, MKRN2, PAIP1, PAIP2, PUM1, RBM47, RBMS1, SMAP2, UNK, YTHDF1, YTHDF3, ZC3HAV1, DHX57, IBTK, PRMT1, R3HDM1, RTCB, TNPO2, ZCCHC3, PRRC2A, FMR1, LSM14A, ZFP36, AGO2, EIF4ENIF1, GKAP1, DHX36, SECISBP2L, TRIP4, CIT, ECT2, KIF14, KIF20A, PHIP, MNDA, AKAP1, BCAR1, nsp12ab, LRRC59, INS, HULC, MKRN1, MKRN3, OGT, FBL, MAPRE3, RPS20, RPS24, FZR1, SRRM2, SRSF12, RALY, YTHDC1, UBE2Q1, YBX1, ZNF326, ZFR, BCLAF1, DKC1, C17orf85, PLXDC2, STRBP, CASC3, FHL2, PABPC4L, WHSC1, C14orf80, GLYR1, ELAVL2, SUGP2, U2SURP, HNRNPCL1, PABPC5, APOBEC3B, PAIP2B, RBMXL1, CLK3, CLK2, CHERP, FASTK, SRSF8, RBMS2, RBBP6, STAU2, LARP7, ZNF777, SRSF1, IGF2BP3, ZC3H11A, PPIG, ICE2, HIST1H1T, FAM120A, SCAF1, GUSBP5, CCL3, TRO, LARP1, PUM2, NCOA5, APOBEC3F, NPAS1, HNRNPC, TRA2A, PNN, SRSF10, APOBEC3D, SHARPIN, METTL21B, C12orf74, DMRTB1, RBPMS, Dynll1, Gnb2l1, Nono, Bbs5, SIRT6, CPEB1, RB1CC1,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
LARP4B	chr10	859076	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
LARP4B	chr10	860990	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
LARP4B	chr10	871816	T	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
LARP4B	chr10	876865	TCA	T	Microsatellite	association	Autism_spectrum_disorder	SO:0001587\|nonsense	SO:0001587\|nonsense

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
LARP4B	COAD	chr10	890939	890939	T	-	Frame_Shift_Del	p.T163fs	37
LARP4B	KIRP	chr10	858887	858887	A	G	Silent	p.T732T	5
LARP4B	LUAD	chr10	860901	860901	G	A	Missense_Mutation	p.P602L	4
LARP4B	LUAD	chr10	910104	910104	C	A	Missense_Mutation	p.W83L	4
LARP4B	LUAD	chr10	910105	910105	A	T	Missense_Mutation	p.W83R	4
LARP4B	COAD	chr10	876909	876909	T	A	Missense_Mutation	p.E253D	4
LARP4B	HNSC	chr10	931622	931622	G	A	Nonsense_Mutation	p.Q14*	3
LARP4B	STAD	chr10	890939	890939	T	-	Frame_Shift_Del		3
LARP4B	COAD	chr10	909765	909765	C	T	Silent	p.P116P	3
LARP4B	UCS	chr10	876893	876893	C	A	Missense_Mutation	p.D259Y	3
LARP4B	BLCA	chr10	860896	860896	G	A	Missense_Mutation	p.H604Y	3
LARP4B	BRCA	chr10	871788	871788	C	A	Missense_Mutation	p.G383V	3
LARP4B	UCS	chr10	909780	909780	G	A	Silent	p.A111A	3
LARP4B	SKCM	chr10	861007	861007	G	A	Missense_Mutation	p.L567F	3
LARP4B	BRCA	chr10	876875	876875	T	-	Frame_Shift_Del	p.I265fs	3
LARP4B	READ	chr10	875487	875487	C	A	Missense_Mutation	p.K321N	3
LARP4B	BRCA	chr10	876876	876876	A	C	Missense_Mutation	p.F264L	3
LARP4B	LGG	chr10	859132	859132	C	T	Missense_Mutation	p.A651T	3
LARP4B	ESCA	chr10	871242	871242	G	A	Missense_Mutation	p.S416F	3
LARP4B	BLCA	chr10	875436	875436	C	T	Silent	p.A338A	3
LARP4B	ESCA	chr10	875405	875405	G	T	Missense_Mutation	p.P349T	3
LARP4B	PRAD	chr10	888969	888969	C	A	Missense_Mutation	p.M183I	3
LARP4B	ESCA	chr10	909779	909779	C	T	Missense_Mutation	p.A112T	3
LARP4B	UCEC	chr10	871078	871078	C	T	Missense_Mutation	p.A471T	3
LARP4B	SKCM	chr10	888923	888923	G	A	Missense_Mutation	p.H199Y	2
LARP4B	BLCA	chr10	888915	888915	C	A	Missense_Mutation	p.K201N	2
LARP4B	ESCA	chr10	871242	871242	G	A	Missense_Mutation		2
LARP4B	LAML	chr10	861204	861204	G	A	Missense_Mutation	p.P429S	2
LARP4B	BRCA	chr10	882385	882385	G	T	Nonsense_Mutation	p.C236*	2
LARP4B	STAD	chr10	871710	871710	C	T	Missense_Mutation	p.R409Q	2
LARP4B	SKCM	chr10	875404	875404	G	A	Missense_Mutation	p.P349L	2
LARP4B	UCEC	chr10	859147	859147	G	A	Nonsense_Mutation	p.R646*	2
LARP4B	STAD	chr10	860754	860754	G	C	Missense_Mutation		2
LARP4B	STAD	chr10	910209	910209	A	G	Missense_Mutation	p.V48A	2
LARP4B	LUAD	chr10	875438	875438	C	T	Missense_Mutation	p.A338T	2
LARP4B	LUAD	chr10	871104	871104	G	A	Missense_Mutation	p.T462I	2
LARP4B	UCEC	chr10	860670	860670	C	T	Silent	p.V213M	2
LARP4B	ESCA	chr10	875405	875405	G	T	Missense_Mutation		2
LARP4B	STAD	chr10	888940	888940	G	A	Missense_Mutation	p.T193M	2
LARP4B	HNSC	chr10	863817	863817	G	A	Nonsense_Mutation	p.Q515*	2
LARP4B	SKCM	chr10	931637	931637	C	T	Missense_Mutation	p.V9I	2
LARP4B	STAD	chr10	860754	860754	G	C	Missense_Mutation	p.H619Q	2
LARP4B	UCEC	chr10	860687	860687	C	T	Missense_Mutation	p.A642T	2
LARP4B	ESCA	chr10	909779	909779	C	T	Missense_Mutation		2
LARP4B	TGCT	chr10	859126	859126	T	A	Missense_Mutation		2
LARP4B	SKCM	chr10	931638	931638	C	T	Silent	p.K8K	2
LARP4B	UCEC	chr10	860918	860918	G	A	Silent	p.R162*	2
LARP4B	ESCA	chr10	858947	858947	C	T	Silent	p.P712P	2
LARP4B	SARC	chr10	860914	860914	G	T	Silent		2
LARP4B	CESC	chr10	890928	890928	G	A	Silent		2
LARP4B	TGCT	chr10	859126	859126	T	A	Missense_Mutation	p.I653F	2
LARP4B	SKCM	chr10	863676	863676	A	T	Missense_Mutation	p.S562T	2
LARP4B	STAD	chr10	930435	930435	A	G	Silent	p.P31P	2
LARP4B	UCEC	chr10	875384	875384	A	G	Missense_Mutation	p.Y356H	2
LARP4B	SKCM	chr10	863796	863796	G	A	Missense_Mutation	p.P522S	2
LARP4B	PCPG	chr10	890943	890943	T	G	Missense_Mutation		2
LARP4B	UCEC	chr10	875433	875433	C	T	Silent	p.T339	2
LARP4B	CESC	chr10	876851	876851	C	T	Missense_Mutation		2
LARP4B	SKCM	chr10	859098	859098	G	A	Missense_Mutation	p.P662L	2
LARP4B	BLCA	chr10	930416	930416	G	A	Nonsense_Mutation	p.Q38*	2
LARP4B	COAD	chr10	858938	858939	-	C	Frame_Shift_Ins	p.G715fs	2
LARP4B	PCPG	chr10	890943	890943	T	G	Missense_Mutation	p.K161N	2
LARP4B	SKCM	chr10	871741	871741	G	A	Missense_Mutation	p.P399S	2
LARP4B	UCEC	chr10	875510	875510	C	T	Missense_Mutation	p.A314T	2
LARP4B	CESC	chr10	875463	875463	C	A	Silent		2
LARP4B	UCEC	chr10	909814	909814	G	T	Missense_Mutation	p.A100D	2
LARP4B	CESC	chr10	930428	930428	G	T	Missense_Mutation		2
LARP4B	SKCM	chr10	871159	871159	G	A	Nonsense_Mutation	p.R444*	2
LARP4B	BRCA	chr10	871204	871204	G	C	Missense_Mutation	p.P429A	2
LARP4B	STAD	chr10	890939	890940	TT	-	Frame_Shift_Del	p.T163fs	2
LARP4B	HNSC	chr10	875449	875449	T	A	Missense_Mutation	p.Q334L	2
LARP4B	LUAD	chr10	863720	863720	T	A	Missense_Mutation	p.E547V	2
LARP4B	ESCA	chr10	860788	860788	T	A	Missense_Mutation	p.D608V	2
LARP4B	KIRP	chr10	888885	888885	C	A	Silent		2
LARP4B	STAD	chr10	930435	930435	A	G	Silent		2
LARP4B	BRCA	chr10	875659	875659	G	A	Nonsense_Mutation	p.R293*	2
LARP4B	COAD	chr10	890957	890957	G	A	Nonsense_Mutation	p.R157X	2
LARP4B	STAD	chr10	875374	875374	A	G	Missense_Mutation	p.I359T	2
LARP4B	STAD	chr10	875656	875656	C	A	Nonsense_Mutation		1
LARP4B	LUAD	chr10	858900	858900	C	T	Missense_Mutation	p.R728Q	1
LARP4B	BLCA	chr10	931589	931589	C	A	Missense_Mutation		1
LARP4B	CESC	chr10	871711	871711	G	A	Nonsense_Mutation		1
LARP4B	LUSC	chr10	863800	863800	T	C	Silent	p.P520P	1
LARP4B	SKCM	chr10	863757	863757	G	A	Missense_Mutation	p.P535S	1
LARP4B	COAD	chr10	860683	860683	G	A	Missense_Mutation	p.T643M	1
LARP4B	UCEC	chr10	858939	858939	C	-	Frame_Shift_Del	p.G715fs	1
LARP4B	HNSC	chr10	909751	909751	G	T	Missense_Mutation		1
LARP4B	LIHC	chr10	859073	859073	T	-	Frame_Shift_Del		1
LARP4B	READ	chr10	871033	871033	C	T	Missense_Mutation	p.E486K	1
LARP4B	STAD	chr10	875402	875402	G	A	Nonsense_Mutation		1
LARP4B	HNSC	chr10	882344	882344	T	A	Splice_Site	p.E250_splice	1
LARP4B	LUAD	chr10	858924	858924	G	A	Missense_Mutation	p.S720L	1
LARP4B	LUAD	chr10	909761	909761	C	A	Nonsense_Mutation	p.E118*	1
LARP4B	BLCA	chr10	888915	888915	C	A	Missense_Mutation		1
LARP4B	CESC	chr10	909788	909788	C	A	Nonsense_Mutation		1
LARP4B	OV	chr10	871158	871158	C	T	Missense_Mutation	p.R444Q	1
LARP4B	SKCM	chr10	890920	890920	G	T	Missense_Mutation	p.S169Y	1
LARP4B	COAD	chr10	861003	861003	C	T	Missense_Mutation	p.S568N	1
LARP4B	ESCA	chr10	858947	858947	C	T	Silent		1
LARP4B	LGG	chr10	882433	882433	G	A	Silent	p.V220V	1
LARP4B	HNSC	chr10	882344	882344	T	A	Missense_Mutation		1
LARP4B	LIHC	chr10	875345	875345	T	A	Missense_Mutation	p.S369C	1
LARP4B	READ	chr10	860951	860951	C	T	Silent	p.S585S	1
LARP4B	COAD	chr10	910082	910082	G	A	Silent	p.H90H	1
LARP4B	TGCT	chr10	871022	871031	AGGAGAGGAT	-	Frame_Shift_Del		1
LARP4B	HNSC	chr10	863665	863665	C	A	Splice_Site	p.R565_splice	1
LARP4B	BLCA	chr10	860896	860896	G	A	Missense_Mutation		1
LARP4B	CESC	chr10	871711	871711	G	A	Nonsense_Mutation	p.R409*	1
LARP4B	OV	chr10	875530	875530	C	T	Missense_Mutation	p.R307Q	1
LARP4B	SKCM	chr10	860738	860738	G	A	Missense_Mutation	p.P625S	1
LARP4B	BLCA	chr10	871052	871052	A	G	Silent	p.R479R	1
LARP4B	COAD	chr10	863810	863810	G	T	Missense_Mutation	p.P517Q	1
LARP4B	LGG	chr10	875496	875496	A	G	Silent	p.F318F	1
LARP4B	HNSC	chr10	863665	863665	C	A	Missense_Mutation		1
LARP4B	LIHC	chr10	876909	876909	T	C	Silent	p.E253E	1
LARP4B	READ	chr10	863670	863670	C	A	Nonsense_Mutation	p.E564X	1
LARP4B	COAD	chr10	910159	910159	C	-	Frame_Shift_Del	p.A65fs	1
LARP4B	BLCA	chr10	866764	866764	C	G	Silent		1
LARP4B	CESC	chr10	876851	876851	C	T	Missense_Mutation	p.D273N	1
LARP4B	TGCT	chr10	871042	871045	CTGG	-	Frame_Shift_Del		1
LARP4B	LUAD	chr10	875333	875333	G	A	Missense_Mutation	p.P373S	1
LARP4B	LUAD	chr10	858953	858961	CCTCTGGTC	-	In_Frame_Del	p.DQR708del	1
LARP4B	PAAD	chr10	871234	871234	G	A	Missense_Mutation		1
LARP4B	SKCM	chr10	930398	930398	G	A	Missense_Mutation	p.P44S	1
LARP4B	BLCA	chr10	866764	866764	C	G	Silent	p.R502R	1
LARP4B	COAD	chr10	871111	871111	T	C	Missense_Mutation	p.T460A	1
LARP4B	LGG	chr10	910103	910103	C	A	Missense_Mutation	p.W83C	1
LARP4B	HNSC	chr10	875361	875361	C	A	Silent		1
LARP4B	LIHC	chr10	860959	860959	C	T	Missense_Mutation	p.E583K	1
LARP4B	COAD	chr10	931589	931589	C	T	Missense_Mutation	p.A25T	1
LARP4B	STAD	chr10	860693	860693	C	T	Missense_Mutation	p.G640R	1
LARP4B	BLCA	chr10	859021	859021	C	G	Missense_Mutation		1
LARP4B	CESC	chr10	909788	909788	C	A	Nonsense_Mutation	p.E109*	1
LARP4B	HNSC	chr10	882344	882344	T	A	Missense_Mutation	p.E250V	1
LARP4B	LUAD	chr10	910104	910105	CA	AT	Missense_Mutation	p.W83M	1
LARP4B	PAAD	chr10	882390	882390	G	T	Missense_Mutation		1
LARP4B	SKCM	chr10	909704	909704	G	T	Missense_Mutation	p.L137M	1
LARP4B	BLCA	chr10	859021	859021	C	G	Missense_Mutation	p.E688Q	1
LARP4B	COAD	chr10	871227	871227	G	A	Missense_Mutation	p.A421V	1
LARP4B	STAD	chr10	875656	875656	C	A	Nonsense_Mutation	p.E294X	1
LARP4B	HNSC	chr10	860989	860989	C	T	Missense_Mutation		1
LARP4B	LIHC	chr10	875366	875366	G	-	Frame_Shift_Del	p.Q362fs	1
LARP4B	COAD	chr10	931610	931611	CT	-	Frame_Shift_Del	p.18_18del	1
LARP4B	STAD	chr10	875402	875402	G	A	Nonsense_Mutation	p.Q350*	1
LARP4B	BLCA	chr10	909737	909737	C	T	Missense_Mutation		1
LARP4B	CESC	chr10	875463	875463	C	A	Silent	p.V329	1
LARP4B	KIRC	chr10	871057	871060	CAGG	-	Frame_Shift_Del	p.477_478del	1
LARP4B	LUAD	chr10	871703	871704	CC	AA	Splice_Site	p.R411_splice	1
LARP4B	PAAD	chr10	871234	871234	G	A	Missense_Mutation	p.R419W	1
LARP4B	SKCM	chr10	871713	871713	G	A	Missense_Mutation	p.P408L	1
LARP4B	BLCA	chr10	860928	860928	G	T	Nonsense_Mutation	p.S593*	1
LARP4B	COAD	chr10	871770	871770	G	A	Missense_Mutation	p.T389M	1
LARP4B	ESCA	chr10	860788	860788	T	A	Missense_Mutation		1
LARP4B	LGG	chr10	859132	859132	C	T	Missense_Mutation		1
LARP4B	HNSC	chr10	863782	863782	G	T	Missense_Mutation		1
LARP4B	LIHC	chr10	882409	882409	T	-	Frame_Shift_Del	p.K228fs	1
LARP4B	SARC	chr10	875521	875521	G	T	Missense_Mutation		1
LARP4B	CESC	chr10	882350	882350	G	T	Missense_Mutation		1
LARP4B	COAD	chr10	890939	890939	T	G	Missense_Mutation	p.T163P	1
LARP4B	STAD	chr10	875656	875656	C	A	Nonsense_Mutation	p.E294*	1
LARP4B	BLCA	chr10	861005	861005	G	A	Silent		1
LARP4B	CESC	chr10	890928	890928	G	A	Silent	p.F166	1
LARP4B	TGCT	chr10	871042	871045	CTGG	-	Frame_Shift_Del	p.482_483del	1
LARP4B	DLBC	chr10	909711	909711	A	G	Silent	p.Y134Y	1
LARP4B	KIRC	chr10	888926	888926	C	T	Missense_Mutation	p.D198N	1
LARP4B	LUAD	chr10	860887	860887	C	A	Missense_Mutation	p.D607Y	1
LARP4B	LGG	chr10	875496	875496	A	G	Silent		1
LARP4B	SKCM	chr10	930436	930436	G	A	Missense_Mutation	p.P31L	1
LARP4B	BLCA	chr10	909737	909737	C	T	Missense_Mutation	p.A126T	1
LARP4B	COAD	chr10	875407	875407	C	T	Missense_Mutation	p.S348N	1
LARP4B	STAD	chr10	875402	875402	G	A	Nonsense_Mutation	p.Q350X	1
LARP4B	GBM	chr10	882389	882389	C	T	Missense_Mutation	p.R235H	1
LARP4B	STAD	chr10	888953	888953	C	T	Missense_Mutation	p.V189M	1
LARP4B	HNSC	chr10	860989	860989	C	T	Missense_Mutation	p.V573M	1
LARP4B	LIHC	chr10	890957	890957	G	-	Frame_Shift_Del	p.R157fs	1
LARP4B	LUAD	chr10	875465	875465	C	A	Missense_Mutation	p.V329L	1
LARP4B	SARC	chr10	863681	863681	C	-	Frame_Shift_Del	p.G560fs	1
LARP4B	LUSC	chr10	890987	890987	C	T	Missense_Mutation	p.E147K	1
LARP4B	TGCT	chr10	871022	871031	AGGAGAGGAT	-	Frame_Shift_Del	p.ESSP486fs	1
LARP4B	GBM	chr10	863788	863788	C	T	Silent		1
LARP4B	LGG	chr10	910103	910103	C	A	Missense_Mutation		1
LARP4B	BLCA	chr10	861005	861005	G	A	Silent	p.L567L	1
LARP4B	STAD	chr10	860914	860914	G	A	Nonsense_Mutation	p.R598X	1
LARP4B	STAD	chr10	860914	860914	G	A	Nonsense_Mutation	p.R598*	1
LARP4B	HNSC	chr10	863782	863782	G	T	Missense_Mutation	p.S526R	1
LARP4B	LIHC	chr10	875387	875387	G	-	Frame_Shift_Del	p.L355fs	1
LARP4B	LUAD	chr10	860887	860887	C	A	Splice_Site	p.D607_splice	1
LARP4B	SKCM	chr10	871159	871159	G	A	Nonsense_Mutation	p.R444X	1
LARP4B	LUSC	chr10	871190	871190	T	C	Silent	p.E433E	1
LARP4B	SKCM	chr10	863758	863758	G	A	Silent	p.F534F	1
LARP4B	COAD	chr10	859016	859016	G	A	Silent	p.P689P	1
LARP4B	THCA	chr10	863763	863763	T	C	Missense_Mutation		1
LARP4B	KIRP	chr10	858887	858887	A	G	Silent		1
LARP4B	GBM	chr10	909749	909749	C	T	Missense_Mutation		1
LARP4B	LIHC	chr10	888918	888918	G	T	Silent		1
LARP4B	SKCM	chr10	890981	890981	G	A	Nonsense_Mutation	p.Q149*	1
LARP4B	BLCA	chr10	860754	860754	G	A	Silent	p.H619H	1
LARP4B	COAD	chr10	882372	882372	G	A	Missense_Mutation	p.R241C	1
LARP4B	STAD	chr10	890938	890939	-	T	Frame_Shift_Ins	p.T163fs	1
LARP4B	STAD	chr10	858975	858975	G	C	Missense_Mutation	p.P703R	1
LARP4B	HNSC	chr10	875361	875361	C	A	Silent	p.T363T	1
LARP4B	LIHC	chr10	882419	882419	T	-	Frame_Shift_Del	p.K225fs	1
LARP4B	LUAD	chr10	910208	910208	T	A	Silent	p.V48V	1
LARP4B	SKCM	chr10	871151	871151	A	-	Frame_Shift_Del	p.N447fs	1
LARP4B	BLCA	chr10	875436	875436	C	T	Silent		1
LARP4B	LUSC	chr10	909706	909706	G	C	Missense_Mutation	p.S136C	1
LARP4B	BLCA	chr10	859104	859104	T	C	Missense_Mutation	p.E660G	1
LARP4B	COAD	chr10	859072	859073	-	T	Frame_Shift_Ins	p.E671fs	1
LARP4B	THCA	chr10	863763	863763	T	C	Missense_Mutation	p.S533G	1
LARP4B	KIRP	chr10	910099	910099	C	A	Nonsense_Mutation		1
LARP4B	GBM	chr10	909820	909820	G	A	Missense_Mutation		1
LARP4B	LIHC	chr10	866757	866757	T	C	Missense_Mutation		1
LARP4B	PRAD	chr10	871233	871233	C	A	Missense_Mutation	p.R419L	1
LARP4B	SKCM	chr10	871151	871151	A	-	Frame_Shift_Del	p.I446fs	1
LARP4B	STAD	chr10	890939	890940	TT	-	Frame_Shift_Del	p.163_163del	1
LARP4B	UCS	chr10	909780	909780	G	A	Silent		1
LARP4B	LUAD	chr10	909732	909732	G	A	Silent	p.L127L	1
LARP4B	SKCM	chr10	890981	890981	G	A	Nonsense_Mutation	p.Q149X	1
LARP4B	BLCA	chr10	859104	859104	T	C	Missense_Mutation		1
LARP4B	CESC	chr10	930428	930428	G	C	Missense_Mutation	p.Q34E	1
LARP4B	LUSC	chr10	871222	871222	G	C	Missense_Mutation	p.P423A	1
LARP4B	SKCM	chr10	859090	859090	G	A	Missense_Mutation	p.P665S	1
LARP4B	BLCA	chr10	931589	931589	C	A	Missense_Mutation	p.A25S	1
LARP4B	COAD	chr10	860592	860593	-	A	Intron	.	1
LARP4B	HNSC	chr10	875449	875449	T	A	Missense_Mutation		1
LARP4B	LIHC	chr10	882435	882435	C	A	Missense_Mutation		1
LARP4B	PRAD	chr10	871034	871034	G	-	Frame_Shift_Del	p.L485fs	1
LARP4B	UCS	chr10	876893	876893	C	A	Missense_Mutation		1

Copy number variation (CNV) of LARP4B
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across LARP4B
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
78488	N/A	CB048810	CCDC144NL	chr17	20790378	-	LARP4B	chr10	855482	+
78488	N/A	AK292946	CCND3	chr6	42016239	-	LARP4B	chr10	931702	-
78488	STAD	TCGA-B7-5818-01A	CEPT1	chr1	111682929	+	LARP4B	chr10	931700	-
78488	SKCM	TCGA-BF-AAP2-01A	DIP2C	chr10	735434	-	LARP4B	chr10	910210	-
78488	N/A	BM991652	JUN	chr1	59248382	+	LARP4B	chr10	856187	+
94696	BRCA	TCGA-BH-A1FD-01A	LARP4B	chr10	888872	-	ADARB2	chr10	1263059	-
94696	STAD	TCGA-CD-A486-01A	LARP4B	chr10	930387	-	ADARB2	chr10	1421355	-
101474	N/A	FN088177	LARP4B	chr10	897111	-	BMPR2	chr2	203432195	+
94131	PRAD	TCGA-HC-A6AN	LARP4B	chr10	909683	-	FAM21C	chr10	46280013	+
44147	LUAD	TCGA-49-4488-01A	LARP4B	chr10	882345	-	IDI2	chr10	1071799	-
78488	N/A	BF328296	LARP4B	chr10	881526	-	LARP4B	chr10	881445	+
44147	SKCM	TCGA-EB-A4IQ-01A	LARP4B	chr10	875325	-	LINC00866	chr10	99589478	-
69186	SKCM	TCGA-FS-A4F4-06A	LARP4B	chr10	909683	-	PAMR1	chr11	35515820	-
89346	BRCA	TCGA-E9-A1R7-01A	LARP4B	chr10	909683	-	PFKFB3	chr10	6255586	+
67661	STAD	TCGA-BR-8058-01A	LARP4B	chr10	930387	-	POLH	chr6	43565433	+
81370	ESCA	TCGA-LN-A4A2	LARP4B	chr10	930386	-	PSMF1	chr20	1143773	+
44147	LUSC	TCGA-22-1012-01A	LARP4B	chr10	882343	-	SMCO3	chr12	14959630	-
86176	N/A	T05378	LARP4B	chr10	876967	+	STAM2	chr2	152986620	+
101886	ESCA	TCGA-LN-A4A8	LARP4B	chr10	875324	-	WDR37	chr10	1170157	+
78498	CHOL	TCGA-W5-AA2U-01A	RSU1	chr10	16858972	-	LARP4B	chr10	863829	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
TGCT	LARP4B	0.000339638192466736	0.0092
THCA	LARP4B	0.0118377451764256	0.31
KIRP	LARP4B	0.0216759101377341	0.54
SKCM	LARP4B	0.0329212314939758	0.79
LAML	LARP4B	0.0492049123041092	1
LUAD	LARP4B	5.95167176245684e-05	0.0017

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
TGCT	LARP4B	0.0318589401066829	0.92
LIHC	LARP4B	0.00097733002340503	0.031
KIRP	LARP4B	0.0451169687013696	1
LGG	LARP4B	3.60518094726392e-07	1.2e-05
PRAD	LARP4B	0.0011845871680819	0.037
UCEC	LARP4B	0.024577478870312	0.74

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C2931456	Prostate cancer, familial	1	CTD_human
C4722327	PROSTATE CANCER, HEREDITARY, 1	1	CTD_human