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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: FMR1 (NCBI Gene ID:2332)

Gene Summary

Gene Summary

Gene Information	Gene Name: FMR1
	Gene ID: 2332
	Gene Symbol	FMR1
	Gene ID	2332
	Gene Name	FMRP translational regulator 1
	Synonyms	FMRP\|FRAXA\|POF\|POF1
	Cytomap	Xq27.3
	Type of Gene	protein-coding
	Description	synaptic functional regulator FMR1fragile X mental retardation 1fragile X mental retardation protein 1truncated FMRP
	Modification date	20200313
	UniProtAcc	Q06787

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0017148	Negative regulation of translation
GO:0006417	Regulation of translation
GO:0045727	Positive regulation of translation
GO:0002181	Cytoplasmic translation
GO:0006413	Translational initiation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	FMR1	GO:0000381	regulation of alternative mRNA splicing, via spliceosome	18653529
Hgene	FMR1	GO:0002092	positive regulation of receptor internalization	25561520
Hgene	FMR1	GO:0006974	cellular response to DNA damage stimulus	24813610
Hgene	FMR1	GO:0033129	positive regulation of histone phosphorylation	24813610
Hgene	FMR1	GO:0045727	positive regulation of translation	19097999\|19166269
Hgene	FMR1	GO:0051489	regulation of filopodium assembly	16631377
Hgene	FMR1	GO:0060998	regulation of dendritic spine development	16631377
Hgene	FMR1	GO:0098586	cellular response to virus	24514761
Hgene	FMR1	GO:0098908	regulation of neuronal action potential	25561520
Hgene	FMR1	GO:1902416	positive regulation of mRNA binding	25464849
Hgene	FMR1	GO:2000637	positive regulation of gene silencing by miRNA	17057366
Hgene	FMR1	GO:2001022	positive regulation of response to DNA damage stimulus	24813610

Inferred gene age of translation factor.

Gene

Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25

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Translation Studies in PubMed

We searched PubMed using 'FMR1[title] AND translation [title] AND human.'

Gene	Title	PMID
FMR1	DDX3X and specific initiation factors modulate FMR1 repeat-associated non-AUG-initiated translation	31347257

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000370475	147007057	147007151	Frame-shift
ENST00000370475	147009839	147009911	In-frame
ENST00000370475	147019617	147019680	In-frame
ENST00000370475	147024650	147024846	Frame-shift

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000370475	147009839	147009911	4325	327	398	632	66	90
ENST00000370475	147019617	147019680	4325	1254	1316	632	375	396

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
KICH	FMR1	1.78310178813069	0.00102710723876953
KIRP	FMR1	-1.94284822624948	0.0099095250479877
BRCA	FMR1	-2.74053611255086	0.0481383834499222
KIRC	FMR1	-2.35406916543664	1.12145348829767e-07
HNSC	FMR1	-2.72606987034586	1.37760207508109e-06

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
HNSC	FMR1	hsa-miR-429	84	0.350649350649351	0.00174748444741186
KIRP	FMR1	hsa-miR-874-3p	90	-0.374320681121106	0.000677688022534202
LUAD	FMR1	hsa-miR-9-5p	85	-0.339345661450925	0.00303951866543256
UCS	FMR1	hsa-miR-429	84	-0.31038961038961	0.0202760007950078

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
CESC	FMR1	1	2	0.00251019511797683	0.147935	0.377743150684932	0.98880115294818	0.322376495413132
READ	FMR1	1	2	0.0316976838332534	0.0617691666666667	0.355142934782609	0.25959115294631	0.463095718164065

Translation factor expression regulation through copy number variation of Translation factor

Cancer type

Gene

Coefficient

Pvalue

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with FMR1 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	Cell metabolism gene	FMR1	MANEA	0.801161339	3.85E-11
CHOL	Cell metabolism gene	FMR1	MTM1	0.807601897	2.03E-11
DLBC	Cell metabolism gene	FMR1	MTM1	0.802896235	6.67E-12
DLBC	Cell metabolism gene	FMR1	MED12	0.81115142	2.74E-12
DLBC	Cell metabolism gene	FMR1	MED14	0.812876733	2.26E-12
DLBC	Cell metabolism gene	FMR1	SMG1	0.825326917	5.36E-13
DLBC	CGC	FMR1	ATM	0.810993628	2.79E-12
DLBC	CGC	FMR1	CBL	0.81114082	2.75E-12
DLBC	CGC	FMR1	MED12	0.81115142	2.74E-12
DLBC	Epifactor	FMR1	SIRT1	0.801290959	7.89E-12
DLBC	Epifactor	FMR1	STK4	0.804151363	5.84E-12
DLBC	Epifactor	FMR1	C11orf30	0.804815167	5.44E-12
DLBC	Epifactor	FMR1	ATM	0.810993628	2.79E-12
DLBC	Epifactor	FMR1	KDM3B	0.81743852	1.35E-12
DLBC	Epifactor	FMR1	TAF4	0.817949451	1.28E-12
DLBC	Epifactor	FMR1	PHF8	0.836150876	1.39E-13
DLBC	IUPHAR	FMR1	SIRT1	0.801290959	7.89E-12
DLBC	IUPHAR	FMR1	STK4	0.804151363	5.84E-12
DLBC	IUPHAR	FMR1	ATM	0.810993628	2.79E-12
DLBC	IUPHAR	FMR1	PDPK1	0.814516498	1.89E-12
DLBC	IUPHAR	FMR1	KDM3B	0.81743852	1.35E-12
DLBC	IUPHAR	FMR1	SMG1	0.825326917	5.36E-13
DLBC	IUPHAR	FMR1	PHF8	0.836150876	1.39E-13
DLBC	Kinase	FMR1	STK4	0.804151363	5.84E-12
DLBC	Kinase	FMR1	ATM	0.810993628	2.79E-12
DLBC	Kinase	FMR1	PDPK1	0.814516498	1.89E-12
DLBC	Kinase	FMR1	SMG1	0.825326917	5.36E-13
DLBC	TF	FMR1	ZFX	0.804061629	5.90E-12
DLBC	TF	FMR1	ZBTB39	0.804165916	5.83E-12
DLBC	TF	FMR1	ATF7	0.80710576	4.26E-12
DLBC	TF	FMR1	ZNF75D	0.820136226	9.91E-13
DLBC	TF	FMR1	TSHZ1	0.822350863	7.65E-13
DLBC	TSG	FMR1	SIRT1	0.801290959	7.89E-12
DLBC	TSG	FMR1	ATM	0.810993628	2.79E-12
DLBC	TSG	FMR1	CBL	0.81114082	2.75E-12
DLBC	TSG	FMR1	KDM3B	0.81743852	1.35E-12
THYM	Cell metabolism gene	FMR1	ALG13	0.835754724	4.97E-33
THYM	CGC	FMR1	STAG2	0.825623209	1.31E-31
THYM	CGC	FMR1	PHF6	0.835332491	5.72E-33
THYM	IUPHAR	FMR1	SLC9A6	0.823068292	2.89E-31
THYM	TF	FMR1	ZNF548	0.804952393	5.63E-29
THYM	TF	FMR1	DMTF1	0.830974155	2.39E-32
THYM	TF	FMR1	ZBTB1	0.837833607	2.47E-33
THYM	TF	FMR1	ZNF280C	0.851189539	2.16E-35
THYM	TF	FMR1	ZNF75D	0.852931092	1.13E-35
THYM	TSG	FMR1	DMTF1	0.830974155	2.39E-32
THYM	TSG	FMR1	PHF6	0.835332491	5.72E-33
UCS	Cell metabolism gene	FMR1	ALG13	0.835754724	4.97E-33
UCS	CGC	FMR1	STAG2	0.825623209	1.31E-31
UCS	CGC	FMR1	PHF6	0.835332491	5.72E-33
UCS	IUPHAR	FMR1	SLC9A6	0.823068292	2.89E-31
UCS	TF	FMR1	ZNF548	0.804952393	5.63E-29
UCS	TF	FMR1	DMTF1	0.830974155	2.39E-32
UCS	TF	FMR1	ZBTB1	0.837833607	2.47E-33
UCS	TF	FMR1	ZNF280C	0.851189539	2.16E-35
UCS	TF	FMR1	ZNF75D	0.852931092	1.13E-35
UCS	TSG	FMR1	DMTF1	0.830974155	2.39E-32
UCS	TSG	FMR1	PHF6	0.835332491	5.72E-33
UVM	Cell metabolism gene	FMR1	AGL	0.800105871	5.45E-19
UVM	Cell metabolism gene	FMR1	DCP2	0.800278155	5.29E-19
UVM	Cell metabolism gene	FMR1	PSMD10	0.802789135	3.40E-19
UVM	Cell metabolism gene	FMR1	PSMC6	0.802977392	3.29E-19
UVM	Cell metabolism gene	FMR1	NUP43	0.805140741	2.23E-19
UVM	Cell metabolism gene	FMR1	ACADM	0.805166095	2.22E-19
UVM	Cell metabolism gene	FMR1	EDEM3	0.808422332	1.23E-19
UVM	Cell metabolism gene	FMR1	IPMK	0.80923125	1.06E-19
UVM	Cell metabolism gene	FMR1	UGGT2	0.810108947	9.02E-20
UVM	Cell metabolism gene	FMR1	GPAM	0.811416519	7.08E-20
UVM	Cell metabolism gene	FMR1	IDI1	0.812070144	6.26E-20
UVM	Cell metabolism gene	FMR1	PDE8A	0.812385388	5.90E-20
UVM	Cell metabolism gene	FMR1	MTMR1	0.813140588	5.12E-20
UVM	Cell metabolism gene	FMR1	SUCLA2	0.814656798	3.84E-20
UVM	Cell metabolism gene	FMR1	TRDMT1	0.814877237	3.69E-20
UVM	Cell metabolism gene	FMR1	UGCG	0.81493331	3.65E-20
UVM	Cell metabolism gene	FMR1	NUDT12	0.814938815	3.64E-20
UVM	Cell metabolism gene	FMR1	GLS	0.815424165	3.32E-20
UVM	Cell metabolism gene	FMR1	TRMT11	0.815676016	3.17E-20
UVM	Cell metabolism gene	FMR1	NUPL2	0.818471692	1.85E-20
UVM	Cell metabolism gene	FMR1	FBXW7	0.818803913	1.73E-20
UVM	Cell metabolism gene	FMR1	GNPDA2	0.819408091	1.54E-20
UVM	Cell metabolism gene	FMR1	AASDHPPT	0.819467673	1.52E-20
UVM	Cell metabolism gene	FMR1	PHAX	0.821140253	1.09E-20
UVM	Cell metabolism gene	FMR1	RORA	0.822781121	7.89E-21
UVM	Cell metabolism gene	FMR1	DBT	0.823566683	6.74E-21
UVM	Cell metabolism gene	FMR1	GNAQ	0.825030146	5.02E-21
UVM	Cell metabolism gene	FMR1	AGPS	0.825520195	4.54E-21
UVM	Cell metabolism gene	FMR1	FAR1	0.826033998	4.09E-21
UVM	Cell metabolism gene	FMR1	UGP2	0.828053318	2.70E-21
UVM	Cell metabolism gene	FMR1	MTR	0.828334089	2.55E-21
UVM	Cell metabolism gene	FMR1	ALG10B	0.830214691	1.72E-21
UVM	Cell metabolism gene	FMR1	PIGA	0.830351268	1.68E-21
UVM	Cell metabolism gene	FMR1	MTMR6	0.830484521	1.63E-21
UVM	Cell metabolism gene	FMR1	C1GALT1	0.8310078	1.46E-21
UVM	Cell metabolism gene	FMR1	MED17	0.833632074	8.36E-22
UVM	Cell metabolism gene	FMR1	ENOPH1	0.833807823	8.05E-22
UVM	Cell metabolism gene	FMR1	VBP1	0.836561905	4.43E-22
UVM	Cell metabolism gene	FMR1	CLOCK	0.83691954	4.10E-22
UVM	Cell metabolism gene	FMR1	NUPL1	0.839596835	2.27E-22
UVM	Cell metabolism gene	FMR1	PPP1CB	0.845287303	6.21E-23
UVM	Cell metabolism gene	FMR1	LPGAT1	0.847363046	3.82E-23
UVM	Cell metabolism gene	FMR1	COL4A3BP	0.848667654	2.81E-23
UVM	Cell metabolism gene	FMR1	NUP54	0.850631821	1.75E-23
UVM	Cell metabolism gene	FMR1	SMG1	0.850760438	1.70E-23
UVM	Cell metabolism gene	FMR1	RFK	0.851084473	1.57E-23
UVM	Cell metabolism gene	FMR1	ETNK1	0.851202318	1.53E-23
UVM	Cell metabolism gene	FMR1	SACM1L	0.851628201	1.38E-23
UVM	Cell metabolism gene	FMR1	PRKAA1	0.854706033	6.47E-24
UVM	Cell metabolism gene	FMR1	ACADSB	0.85739806	3.29E-24
UVM	Cell metabolism gene	FMR1	DCK	0.858240889	2.66E-24
UVM	Cell metabolism gene	FMR1	PIK3CA	0.860081452	1.66E-24
UVM	Cell metabolism gene	FMR1	NAMPT	0.864129901	5.71E-25
UVM	Cell metabolism gene	FMR1	MANEA	0.8647931	4.78E-25
UVM	Cell metabolism gene	FMR1	FBXL3	0.866122046	3.34E-25
UVM	Cell metabolism gene	FMR1	RANBP2	0.866150948	3.31E-25
UVM	Cell metabolism gene	FMR1	PIKFYVE	0.869846627	1.20E-25
UVM	Cell metabolism gene	FMR1	ACSL4	0.872015436	6.48E-26
UVM	Cell metabolism gene	FMR1	MTM1	0.880018791	6.11E-27
UVM	Cell metabolism gene	FMR1	PNPLA8	0.883308123	2.20E-27
UVM	Cell metabolism gene	FMR1	CSGALNACT2	0.884589831	1.47E-27
UVM	Cell metabolism gene	FMR1	GXYLT1	0.88516089	1.22E-27
UVM	CGC	FMR1	RAD17	0.800107144	5.45E-19
UVM	CGC	FMR1	ARID2	0.802868452	3.35E-19
UVM	CGC	FMR1	ARHGAP5	0.804546811	2.48E-19
UVM	CGC	FMR1	ABI1	0.804716777	2.41E-19
UVM	CGC	FMR1	JAK2	0.807825097	1.37E-19
UVM	CGC	FMR1	CUL3	0.807941755	1.34E-19
UVM	CGC	FMR1	STAG1	0.809066003	1.09E-19
UVM	CGC	FMR1	APC	0.809246498	1.06E-19
UVM	CGC	FMR1	MSH2	0.809399582	1.03E-19
UVM	CGC	FMR1	TRIM33	0.809466929	1.02E-19
UVM	CGC	FMR1	KTN1	0.809878344	9.42E-20
UVM	CGC	FMR1	ITGAV	0.810726205	8.05E-20
UVM	CGC	FMR1	N4BP2	0.811647337	6.78E-20
UVM	CGC	FMR1	DDX10	0.812541655	5.73E-20
UVM	CGC	FMR1	FBXO11	0.81277187	5.49E-20
UVM	CGC	FMR1	ATRX	0.815439109	3.31E-20
UVM	CGC	FMR1	PMS1	0.815794663	3.09E-20
UVM	CGC	FMR1	USP8	0.817219455	2.35E-20
UVM	CGC	FMR1	ERCC4	0.817795082	2.11E-20
UVM	CGC	FMR1	CREB1	0.818385393	1.88E-20
UVM	CGC	FMR1	FBXW7	0.818803913	1.73E-20
UVM	CGC	FMR1	CDKN1B	0.82098937	1.13E-20
UVM	CGC	FMR1	MAP3K1	0.823181738	7.28E-21
UVM	CGC	FMR1	GNAQ	0.825030146	5.02E-21
UVM	CGC	FMR1	SMAD4	0.827310497	3.15E-21
UVM	CGC	FMR1	ATF1	0.831353849	1.36E-21
UVM	CGC	FMR1	CDC73	0.833809839	8.04E-22
UVM	CGC	FMR1	KIF5B	0.840742033	1.76E-22
UVM	CGC	FMR1	DEK	0.842336772	1.22E-22
UVM	CGC	FMR1	ETNK1	0.851202318	1.53E-23
UVM	CGC	FMR1	DDX5	0.851736277	1.34E-23
UVM	CGC	FMR1	MLLT10	0.853465853	8.80E-24
UVM	CGC	FMR1	SF3B1	0.858106562	2.75E-24
UVM	CGC	FMR1	DICER1	0.858156957	2.71E-24
UVM	CGC	FMR1	PIK3CA	0.860081452	1.66E-24
UVM	CGC	FMR1	GOPC	0.860440207	1.51E-24
UVM	CGC	FMR1	SUZ12	0.863463679	6.82E-25
UVM	CGC	FMR1	RANBP2	0.866150948	3.31E-25
UVM	CGC	FMR1	STAG2	0.871919333	6.66E-26
UVM	CGC	FMR1	BCLAF1	0.872770445	5.22E-26
UVM	CGC	FMR1	RGPD3	0.874589441	3.09E-26
UVM	CGC	FMR1	PHF6	0.881302468	4.12E-27
UVM	CGC	FMR1	MALT1	0.912187683	5.91E-32
UVM	Epifactor	FMR1	ERCC6	0.802068469	3.86E-19
UVM	Epifactor	FMR1	UCHL5	0.802643778	3.49E-19
UVM	Epifactor	FMR1	ARID2	0.802868452	3.35E-19
UVM	Epifactor	FMR1	USP46	0.802968812	3.29E-19
UVM	Epifactor	FMR1	HAT1	0.804154603	2.66E-19
UVM	Epifactor	FMR1	YY1	0.804979672	2.30E-19
UVM	Epifactor	FMR1	MYSM1	0.80633932	1.80E-19
UVM	Epifactor	FMR1	ZRANB3	0.806378194	1.79E-19
UVM	Epifactor	FMR1	ATAD2B	0.807060961	1.58E-19
UVM	Epifactor	FMR1	JAK2	0.807825097	1.37E-19
UVM	Epifactor	FMR1	CUL3	0.807941755	1.34E-19
UVM	Epifactor	FMR1	SIRT1	0.808880351	1.13E-19
UVM	Epifactor	FMR1	TRIM33	0.809466929	1.02E-19
UVM	Epifactor	FMR1	TAF1	0.812333561	5.96E-20
UVM	Epifactor	FMR1	USP15	0.813850085	4.48E-20
UVM	Epifactor	FMR1	ATF2	0.814273398	4.14E-20
UVM	Epifactor	FMR1	ATRX	0.815439109	3.31E-20
UVM	Epifactor	FMR1	PCGF6	0.815445282	3.31E-20
UVM	Epifactor	FMR1	ARID4A	0.815564143	3.23E-20
UVM	Epifactor	FMR1	TAF7	0.816561011	2.67E-20
UVM	Epifactor	FMR1	PHC3	0.817059212	2.43E-20
UVM	Epifactor	FMR1	SENP1	0.818052097	2.00E-20
UVM	Epifactor	FMR1	BRMS1L	0.818923638	1.69E-20
UVM	Epifactor	FMR1	CHD1	0.819841111	1.41E-20
UVM	Epifactor	FMR1	CHUK	0.81987232	1.40E-20
UVM	Epifactor	FMR1	HCFC2	0.821879656	9.45E-21
UVM	Epifactor	FMR1	BRWD3	0.823631202	6.66E-21
UVM	Epifactor	FMR1	RCOR3	0.826399846	3.80E-21
UVM	Epifactor	FMR1	WAC	0.827293285	3.16E-21
UVM	Epifactor	FMR1	RSF1	0.827425879	3.08E-21
UVM	Epifactor	FMR1	SMEK1	0.827816871	2.84E-21
UVM	Epifactor	FMR1	OGT	0.829229636	2.12E-21
UVM	Epifactor	FMR1	DNTTIP2	0.829272248	2.10E-21
UVM	Epifactor	FMR1	CTBP2	0.829421844	2.03E-21
UVM	Epifactor	FMR1	MSL3	0.832423055	1.08E-21
UVM	Epifactor	FMR1	FAM175B	0.832569808	1.05E-21
UVM	Epifactor	FMR1	CDC73	0.833809839	8.04E-22
UVM	Epifactor	FMR1	CLOCK	0.83691954	4.10E-22
UVM	Epifactor	FMR1	ARID4B	0.837016528	4.01E-22
UVM	Epifactor	FMR1	MPHOSPH8	0.83768204	3.47E-22
UVM	Epifactor	FMR1	RLIM	0.841359513	1.53E-22
UVM	Epifactor	FMR1	DEK	0.842336772	1.22E-22
UVM	Epifactor	FMR1	JMJD1C	0.842530049	1.17E-22
UVM	Epifactor	FMR1	EPC1	0.844421416	7.59E-23
UVM	Epifactor	FMR1	PHIP	0.845878806	5.42E-23
UVM	Epifactor	FMR1	BAZ2B	0.846516812	4.67E-23
UVM	Epifactor	FMR1	TAF9B	0.847302695	3.88E-23
UVM	Epifactor	FMR1	CUL4B	0.847403083	3.79E-23
UVM	Epifactor	FMR1	TLK1	0.848416231	2.98E-23
UVM	Epifactor	FMR1	MGEA5	0.848535989	2.90E-23
UVM	Epifactor	FMR1	MLLT10	0.853465853	8.80E-24
UVM	Epifactor	FMR1	PRKAA1	0.854706033	6.47E-24
UVM	Epifactor	FMR1	SHPRH	0.85810535	2.75E-24
UVM	Epifactor	FMR1	SF3B1	0.858106562	2.75E-24
UVM	Epifactor	FMR1	YEATS4	0.858251601	2.65E-24
UVM	Epifactor	FMR1	UHRF2	0.859956307	1.71E-24
UVM	Epifactor	FMR1	SMEK2	0.86001877	1.68E-24
UVM	Epifactor	FMR1	CUL5	0.861635901	1.10E-24
UVM	Epifactor	FMR1	NIPBL	0.861677544	1.09E-24
UVM	Epifactor	FMR1	CHD9	0.861927018	1.02E-24
UVM	Epifactor	FMR1	SUZ12	0.863463679	6.82E-25
UVM	Epifactor	FMR1	EPC2	0.865100813	4.40E-25
UVM	Epifactor	FMR1	UBE2D1	0.869208092	1.43E-25
UVM	Epifactor	FMR1	CUL2	0.878618096	9.35E-27
UVM	Epifactor	FMR1	RMI1	0.885008481	1.29E-27
UVM	Epifactor	FMR1	BRCC3	0.895702956	3.52E-29
UVM	Epifactor	FMR1	ZMYND11	0.910374635	1.27E-31
UVM	IUPHAR	FMR1	MAPK8	0.80199986	3.91E-19
UVM	IUPHAR	FMR1	HAT1	0.804154603	2.66E-19
UVM	IUPHAR	FMR1	VRK2	0.805046309	2.27E-19
UVM	IUPHAR	FMR1	ATAD2B	0.807060961	1.58E-19
UVM	IUPHAR	FMR1	JAK2	0.807825097	1.37E-19
UVM	IUPHAR	FMR1	SIRT1	0.808880351	1.13E-19
UVM	IUPHAR	FMR1	TBK1	0.809317001	1.04E-19
UVM	IUPHAR	FMR1	TRIM33	0.809466929	1.02E-19
UVM	IUPHAR	FMR1	ITGAV	0.810726205	8.05E-20
UVM	IUPHAR	FMR1	HIPK3	0.811372975	7.13E-20
UVM	IUPHAR	FMR1	NIPA1	0.811518035	6.94E-20
UVM	IUPHAR	FMR1	SLC25A46	0.811588321	6.85E-20
UVM	IUPHAR	FMR1	IDI1	0.812070144	6.26E-20
UVM	IUPHAR	FMR1	TAF1	0.812333561	5.96E-20
UVM	IUPHAR	FMR1	PDE8A	0.812385388	5.90E-20
UVM	IUPHAR	FMR1	FBXO11	0.81277187	5.49E-20
UVM	IUPHAR	FMR1	PKN2	0.813060715	5.20E-20
UVM	IUPHAR	FMR1	CLK4	0.8147217	3.80E-20
UVM	IUPHAR	FMR1	UGCG	0.81493331	3.65E-20
UVM	IUPHAR	FMR1	GLS	0.815424165	3.32E-20
UVM	IUPHAR	FMR1	SENP1	0.818052097	2.00E-20
UVM	IUPHAR	FMR1	NR2C1	0.819062589	1.65E-20
UVM	IUPHAR	FMR1	CHUK	0.81987232	1.40E-20
UVM	IUPHAR	FMR1	SLC30A5	0.820658167	1.20E-20
UVM	IUPHAR	FMR1	RORA	0.822781121	7.89E-21
UVM	IUPHAR	FMR1	MAP3K1	0.823181738	7.28E-21
UVM	IUPHAR	FMR1	BRWD3	0.823631202	6.66E-21
UVM	IUPHAR	FMR1	SENP6	0.824953003	5.10E-21
UVM	IUPHAR	FMR1	GNAQ	0.825030146	5.02E-21
UVM	IUPHAR	FMR1	USP14	0.826008149	4.11E-21
UVM	IUPHAR	FMR1	NR3C1	0.827904828	2.79E-21
UVM	IUPHAR	FMR1	MTR	0.828334089	2.55E-21
UVM	IUPHAR	FMR1	SENP7	0.829634951	1.95E-21
UVM	IUPHAR	FMR1	PRPF4B	0.829811483	1.88E-21
UVM	IUPHAR	FMR1	RIOK3	0.833408329	8.77E-22
UVM	IUPHAR	FMR1	NEK1	0.836167946	4.83E-22
UVM	IUPHAR	FMR1	USP1	0.836584814	4.41E-22
UVM	IUPHAR	FMR1	SLC25A24	0.836585457	4.41E-22
UVM	IUPHAR	FMR1	CLOCK	0.83691954	4.10E-22
UVM	IUPHAR	FMR1	ABCA10	0.837511499	3.60E-22
UVM	IUPHAR	FMR1	ATP11B	0.840520674	1.84E-22
UVM	IUPHAR	FMR1	JMJD1C	0.842530049	1.17E-22
UVM	IUPHAR	FMR1	NEK7	0.843460864	9.47E-23
UVM	IUPHAR	FMR1	PHIP	0.845878806	5.42E-23
UVM	IUPHAR	FMR1	BAZ2B	0.846516812	4.67E-23
UVM	IUPHAR	FMR1	MAP3K2	0.846891017	4.27E-23
UVM	IUPHAR	FMR1	TLK1	0.848416231	2.98E-23
UVM	IUPHAR	FMR1	TNKS2	0.849990515	2.05E-23
UVM	IUPHAR	FMR1	SMG1	0.850760438	1.70E-23
UVM	IUPHAR	FMR1	SCYL2	0.851975481	1.27E-23
UVM	IUPHAR	FMR1	TGFBR1	0.853256107	9.26E-24
UVM	IUPHAR	FMR1	TRPM7	0.853560753	8.59E-24
UVM	IUPHAR	FMR1	STK38L	0.853769952	8.16E-24
UVM	IUPHAR	FMR1	PRKAA1	0.854706033	6.47E-24
UVM	IUPHAR	FMR1	ABCA5	0.855112868	5.85E-24
UVM	IUPHAR	FMR1	MFN1	0.856976747	3.66E-24
UVM	IUPHAR	FMR1	YES1	0.86005402	1.67E-24
UVM	IUPHAR	FMR1	PIK3CA	0.860081452	1.66E-24
UVM	IUPHAR	FMR1	CSNK1G3	0.869587843	1.29E-25
UVM	IUPHAR	FMR1	PIKFYVE	0.869846627	1.20E-25
UVM	IUPHAR	FMR1	CASK	0.874643845	3.04E-26
UVM	IUPHAR	FMR1	XIAP	0.875773497	2.18E-26
UVM	IUPHAR	FMR1	BIRC2	0.877887705	1.16E-26
UVM	IUPHAR	FMR1	SLC2A13	0.879490032	7.18E-27
UVM	IUPHAR	FMR1	SLK	0.885158808	1.23E-27
UVM	IUPHAR	FMR1	ZMYND11	0.910374635	1.27E-31
UVM	IUPHAR	FMR1	MALT1	0.912187683	5.91E-32
UVM	Kinase	FMR1	MAPK8	0.80199986	3.91E-19
UVM	Kinase	FMR1	VRK2	0.805046309	2.27E-19
UVM	Kinase	FMR1	JAK2	0.807825097	1.37E-19
UVM	Kinase	FMR1	TBK1	0.809317001	1.04E-19
UVM	Kinase	FMR1	TRIM33	0.809466929	1.02E-19
UVM	Kinase	FMR1	HIPK3	0.811372975	7.13E-20
UVM	Kinase	FMR1	TAF1	0.812333561	5.96E-20
UVM	Kinase	FMR1	PKN2	0.813060715	5.20E-20
UVM	Kinase	FMR1	CLK4	0.8147217	3.80E-20
UVM	Kinase	FMR1	CHUK	0.81987232	1.40E-20
UVM	Kinase	FMR1	MAP3K1	0.823181738	7.28E-21
UVM	Kinase	FMR1	PAN3	0.828875496	2.28E-21
UVM	Kinase	FMR1	PRPF4B	0.829811483	1.88E-21
UVM	Kinase	FMR1	RIOK3	0.833408329	8.77E-22
UVM	Kinase	FMR1	NEK1	0.836167946	4.83E-22
UVM	Kinase	FMR1	NEK7	0.843460864	9.47E-23
UVM	Kinase	FMR1	MAP3K2	0.846891017	4.27E-23
UVM	Kinase	FMR1	TLK1	0.848416231	2.98E-23
UVM	Kinase	FMR1	COL4A3BP	0.848667654	2.81E-23
UVM	Kinase	FMR1	SMG1	0.850760438	1.70E-23
UVM	Kinase	FMR1	SCYL2	0.851975481	1.27E-23
UVM	Kinase	FMR1	TGFBR1	0.853256107	9.26E-24
UVM	Kinase	FMR1	TRPM7	0.853560753	8.59E-24
UVM	Kinase	FMR1	STK38L	0.853769952	8.16E-24
UVM	Kinase	FMR1	PRKAA1	0.854706033	6.47E-24
UVM	Kinase	FMR1	YES1	0.86005402	1.67E-24
UVM	Kinase	FMR1	CSNK1G3	0.869587843	1.29E-25
UVM	Kinase	FMR1	CASK	0.874643845	3.04E-26
UVM	Kinase	FMR1	SLK	0.885158808	1.23E-27
UVM	TF	FMR1	ZNF780A	0.800317241	5.25E-19
UVM	TF	FMR1	ZNF529	0.800678391	4.93E-19
UVM	TF	FMR1	ZNF44	0.801236766	4.47E-19
UVM	TF	FMR1	JRKL	0.801738997	4.09E-19
UVM	TF	FMR1	ZNF799	0.802435183	3.62E-19
UVM	TF	FMR1	ZNF708	0.802490554	3.58E-19
UVM	TF	FMR1	THAP2	0.802624242	3.50E-19
UVM	TF	FMR1	ARID2	0.802868452	3.35E-19
UVM	TF	FMR1	ZNF10	0.802872811	3.35E-19
UVM	TF	FMR1	RLF	0.802997883	3.27E-19
UVM	TF	FMR1	ZNF808	0.803729895	2.87E-19
UVM	TF	FMR1	THAP1	0.804965898	2.30E-19
UVM	TF	FMR1	YY1	0.804979672	2.30E-19
UVM	TF	FMR1	TTF1	0.806136912	1.87E-19
UVM	TF	FMR1	MYSM1	0.80633932	1.80E-19
UVM	TF	FMR1	VEZF1	0.806698417	1.69E-19
UVM	TF	FMR1	ZNF383	0.806748226	1.67E-19
UVM	TF	FMR1	ZNF518A	0.807411552	1.48E-19
UVM	TF	FMR1	ZNF587	0.807582266	1.43E-19
UVM	TF	FMR1	ZNF721	0.807849119	1.37E-19
UVM	TF	FMR1	ZNF443	0.80795382	1.34E-19
UVM	TF	FMR1	ZBTB6	0.808209814	1.28E-19
UVM	TF	FMR1	CEBPZ	0.808253529	1.27E-19
UVM	TF	FMR1	GABPA	0.809256379	1.06E-19
UVM	TF	FMR1	ZNF83	0.81008179	9.07E-20
UVM	TF	FMR1	ZNF81	0.811542468	6.91E-20
UVM	TF	FMR1	ZNF280D	0.811796097	6.59E-20
UVM	TF	FMR1	ZNF627	0.813265447	5.00E-20
UVM	TF	FMR1	SKIL	0.813692629	4.62E-20
UVM	TF	FMR1	ZBED5	0.813935794	4.41E-20
UVM	TF	FMR1	ZNF268	0.814175749	4.21E-20
UVM	TF	FMR1	ZNF235	0.814196065	4.20E-20
UVM	TF	FMR1	ZNF302	0.814238596	4.16E-20
UVM	TF	FMR1	ATF2	0.814273398	4.14E-20
UVM	TF	FMR1	ZUFSP	0.814535631	3.93E-20
UVM	TF	FMR1	ZNF267	0.815209673	3.46E-20
UVM	TF	FMR1	PCGF6	0.815445282	3.31E-20
UVM	TF	FMR1	ZFP30	0.815447156	3.31E-20
UVM	TF	FMR1	PRDM10	0.816084158	2.93E-20
UVM	TF	FMR1	NKRF	0.81610883	2.91E-20
UVM	TF	FMR1	ZNF600	0.816275826	2.82E-20
UVM	TF	FMR1	ZNF195	0.81691149	2.50E-20
UVM	TF	FMR1	ZNF776	0.817086204	2.41E-20
UVM	TF	FMR1	CREBZF	0.817979337	2.03E-20
UVM	TF	FMR1	CREB1	0.818385393	1.88E-20
UVM	TF	FMR1	ZNF26	0.818498942	1.84E-20
UVM	TF	FMR1	ZNF658	0.818773561	1.74E-20
UVM	TF	FMR1	ZNF525	0.818866945	1.71E-20
UVM	TF	FMR1	NR2C1	0.819062589	1.65E-20
UVM	TF	FMR1	ZNF23	0.819457517	1.52E-20
UVM	TF	FMR1	ZNF326	0.819728762	1.44E-20
UVM	TF	FMR1	ZNF320	0.819949079	1.38E-20
UVM	TF	FMR1	ZNF493	0.820451592	1.25E-20
UVM	TF	FMR1	MYNN	0.820907603	1.15E-20
UVM	TF	FMR1	ZNF674	0.821163244	1.09E-20
UVM	TF	FMR1	ZNF625	0.821502369	1.02E-20
UVM	TF	FMR1	RORA	0.822781121	7.89E-21
UVM	TF	FMR1	ZBTB41	0.824924544	5.13E-21
UVM	TF	FMR1	ZNF148	0.8263342	3.85E-21
UVM	TF	FMR1	LCOR	0.826485478	3.73E-21
UVM	TF	FMR1	SMAD4	0.827310497	3.15E-21
UVM	TF	FMR1	ZNF654	0.827857226	2.82E-21
UVM	TF	FMR1	NR3C1	0.827904828	2.79E-21
UVM	TF	FMR1	ZNF227	0.828447205	2.49E-21
UVM	TF	FMR1	ZNF558	0.82847486	2.48E-21
UVM	TF	FMR1	ZNF585A	0.829254794	2.11E-21
UVM	TF	FMR1	ZNF800	0.83030357	1.69E-21
UVM	TF	FMR1	ZNF420	0.830942068	1.48E-21
UVM	TF	FMR1	ZNF354B	0.830978865	1.47E-21
UVM	TF	FMR1	ATF1	0.831353849	1.36E-21
UVM	TF	FMR1	ZNF470	0.831448055	1.33E-21
UVM	TF	FMR1	ZNF91	0.83417869	7.43E-22
UVM	TF	FMR1	ZNF701	0.834218667	7.37E-22
UVM	TF	FMR1	ZNF527	0.834882396	6.39E-22
UVM	TF	FMR1	ZNF254	0.835035499	6.18E-22
UVM	TF	FMR1	ZNF585B	0.835100916	6.09E-22
UVM	TF	FMR1	ZNF484	0.835390257	5.72E-22
UVM	TF	FMR1	AHCTF1	0.835902702	5.12E-22
UVM	TF	FMR1	ZNF606	0.836181892	4.82E-22
UVM	TF	FMR1	ZNF461	0.836688702	4.31E-22
UVM	TF	FMR1	CLOCK	0.83691954	4.10E-22
UVM	TF	FMR1	ZNF569	0.837247149	3.82E-22
UVM	TF	FMR1	ZBTB1	0.837559674	3.56E-22
UVM	TF	FMR1	ZNF25	0.837947267	3.27E-22
UVM	TF	FMR1	ZNF248	0.838126301	3.14E-22
UVM	TF	FMR1	ZBTB49	0.838237491	3.07E-22
UVM	TF	FMR1	ZNF184	0.838361919	2.98E-22
UVM	TF	FMR1	ZNF644	0.838368739	2.98E-22
UVM	TF	FMR1	ZNF440	0.838466202	2.92E-22
UVM	TF	FMR1	ZNF431	0.838870431	2.67E-22
UVM	TF	FMR1	TOPORS	0.839968701	2.09E-22
UVM	TF	FMR1	ZNF468	0.840147132	2.01E-22
UVM	TF	FMR1	ZNF770	0.841124745	1.61E-22
UVM	TF	FMR1	ZNF75D	0.84113392	1.61E-22
UVM	TF	FMR1	ZNF700	0.841454287	1.49E-22
UVM	TF	FMR1	MEF2A	0.842823446	1.10E-22
UVM	TF	FMR1	ZNF780B	0.843348583	9.72E-23
UVM	TF	FMR1	ZFP14	0.843402168	9.60E-23
UVM	TF	FMR1	ZNF14	0.843787256	8.79E-23
UVM	TF	FMR1	DMTF1	0.843915031	8.53E-23
UVM	TF	FMR1	HDX	0.844074993	8.22E-23
UVM	TF	FMR1	ZNF181	0.845209446	6.33E-23
UVM	TF	FMR1	ZNF37A	0.845972609	5.30E-23
UVM	TF	FMR1	BAZ2B	0.846516812	4.67E-23
UVM	TF	FMR1	ZNF280C	0.846769696	4.40E-23
UVM	TF	FMR1	ZNF845	0.848330854	3.04E-23
UVM	TF	FMR1	ZNF765	0.848958923	2.62E-23
UVM	TF	FMR1	THAP9	0.850814815	1.68E-23
UVM	TF	FMR1	ZNF567	0.851005016	1.60E-23
UVM	TF	FMR1	ZNF234	0.851294086	1.50E-23
UVM	TF	FMR1	ZNF441	0.851849777	1.31E-23
UVM	TF	FMR1	ZNF782	0.851935268	1.28E-23
UVM	TF	FMR1	ZFX	0.852443598	1.13E-23
UVM	TF	FMR1	IKZF5	0.853395352	8.95E-24
UVM	TF	FMR1	LIN54	0.853926453	7.85E-24
UVM	TF	FMR1	ZBTB11	0.855171794	5.76E-24
UVM	TF	FMR1	ELF2	0.855765655	4.97E-24
UVM	TF	FMR1	ZNF397	0.855796598	4.93E-24
UVM	TF	FMR1	SMAD5	0.856212934	4.44E-24
UVM	TF	FMR1	ZNF131	0.856243528	4.41E-24
UVM	TF	FMR1	THAP5	0.858017039	2.81E-24
UVM	TF	FMR1	ZNF510	0.859150297	2.11E-24
UVM	TF	FMR1	ZNF347	0.860406401	1.52E-24
UVM	TF	FMR1	ZNF33A	0.860430043	1.51E-24
UVM	TF	FMR1	ZNF160	0.86053769	1.47E-24
UVM	TF	FMR1	TMF1	0.864087153	5.77E-25
UVM	TF	FMR1	ZNF430	0.864688158	4.92E-25
UVM	TF	FMR1	ZNF292	0.864771724	4.81E-25
UVM	TF	FMR1	ZNF611	0.86491841	4.62E-25
UVM	TF	FMR1	THAP6	0.865756568	3.69E-25
UVM	TF	FMR1	ZNF761	0.866283523	3.19E-25
UVM	TF	FMR1	ZNF41	0.866852411	2.74E-25
UVM	TF	FMR1	ZNF180	0.867013722	2.62E-25
UVM	TF	FMR1	ZNF432	0.870561989	9.78E-26
UVM	TF	FMR1	GPBP1	0.870609638	9.65E-26
UVM	TF	FMR1	ZNF28	0.873503739	4.23E-26
UVM	TF	FMR1	NFXL1	0.878890903	8.61E-27
UVM	TF	FMR1	ZNF136	0.880785432	4.83E-27
UVM	TF	FMR1	ZNF791	0.882922374	2.49E-27
UVM	TF	FMR1	SP3	0.88714459	6.45E-28
UVM	TSG	FMR1	ARID2	0.802868452	3.35E-19
UVM	TSG	FMR1	TTF1	0.806136912	1.87E-19
UVM	TSG	FMR1	LIN9	0.806604351	1.71E-19
UVM	TSG	FMR1	RBL2	0.807680137	1.41E-19
UVM	TSG	FMR1	SIRT1	0.808880351	1.13E-19
UVM	TSG	FMR1	APC	0.809246498	1.06E-19
UVM	TSG	FMR1	MSH2	0.809399582	1.03E-19
UVM	TSG	FMR1	ITGAV	0.810726205	8.05E-20
UVM	TSG	FMR1	GGNBP2	0.81080951	7.92E-20
UVM	TSG	FMR1	SKIL	0.813692629	4.62E-20
UVM	TSG	FMR1	PHC3	0.817059212	2.43E-20
UVM	TSG	FMR1	NEDD4	0.818675371	1.77E-20
UVM	TSG	FMR1	FBXW7	0.818803913	1.73E-20
UVM	TSG	FMR1	CHD1	0.819841111	1.41E-20
UVM	TSG	FMR1	CHUK	0.81987232	1.40E-20
UVM	TSG	FMR1	CDKN1B	0.82098937	1.13E-20
UVM	TSG	FMR1	SMCHD1	0.823651685	6.63E-21
UVM	TSG	FMR1	SMAD4	0.827310497	3.15E-21
UVM	TSG	FMR1	USP33	0.832723613	1.01E-21
UVM	TSG	FMR1	GORAB	0.833040212	9.49E-22
UVM	TSG	FMR1	CDC73	0.833809839	8.04E-22
UVM	TSG	FMR1	FAM188A	0.836466385	4.53E-22
UVM	TSG	FMR1	RB1CC1	0.837607461	3.52E-22
UVM	TSG	FMR1	KRIT1	0.839583139	2.28E-22
UVM	TSG	FMR1	TOPORS	0.839968701	2.09E-22
UVM	TSG	FMR1	RCHY1	0.840345348	1.92E-22
UVM	TSG	FMR1	WDR11	0.842808706	1.10E-22
UVM	TSG	FMR1	DMTF1	0.843915031	8.53E-23
UVM	TSG	FMR1	INTS6	0.844411333	7.61E-23
UVM	TSG	FMR1	CCAR1	0.854230432	7.28E-24
UVM	TSG	FMR1	PRKAA1	0.854706033	6.47E-24
UVM	TSG	FMR1	RBBP8	0.85692762	3.71E-24
UVM	TSG	FMR1	SHPRH	0.85810535	2.75E-24
UVM	TSG	FMR1	DICER1	0.858156957	2.71E-24
UVM	TSG	FMR1	UHRF2	0.859956307	1.71E-24
UVM	TSG	FMR1	VEZT	0.860243399	1.59E-24
UVM	TSG	FMR1	CUL5	0.861635901	1.10E-24
UVM	TSG	FMR1	SUZ12	0.863463679	6.82E-25
UVM	TSG	FMR1	ZNF292	0.864771724	4.81E-25
UVM	TSG	FMR1	DCLRE1A	0.867925842	2.04E-25
UVM	TSG	FMR1	CUL2	0.878618096	9.35E-27
UVM	TSG	FMR1	PHF6	0.881302468	4.12E-27
UVM	TSG	FMR1	PPM1A	0.882898238	2.51E-27
UVM	TSG	FMR1	TANK	0.891085031	1.74E-28
UVM	TSG	FMR1	ZMYND11	0.910374635	1.27E-31

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
COAD	FMR1	NUFIP2	-2.74904714095693	0.0012979805469513
LIHC	FMR1	FXR1	-1.34222849900153	0.00221270975997039
CHOL	FMR1	CAPRIN1	-1.92523643204408	0.00390625
THCA	FMR1	NUFIP2	1.21346414930112	0.00745605759178186
CHOL	FMR1	CYFIP1	-2.7780697871673	0.0078125
KICH	FMR1	CAPRIN1	1.804235261744	0.00882232189178467
BLCA	FMR1	NUFIP2	-2.33563530587936	0.0108261108398438
PRAD	FMR1	DICER1	1.54768558737379	0.0130781232419534
THCA	FMR1	CYFIP2	1.90181293917412	0.0176042512051157
BLCA	FMR1	CAPRIN1	-3.69281210398604	0.0180816650390625
HNSC	FMR1	FXR1	1.42033860536739	0.03633773249976
COAD	FMR1	FXR2	1.01105544222868	0.0407472252845765
BRCA	FMR1	CYFIP2	-1.47325685264116	1.38509705928293e-11
PRAD	FMR1	CYFIP1	-1.10818424355985	1.48880035272649e-05
KIRP	FMR1	CYFIP2	-1.46566210299983	4.6566128730774e-10
BRCA	FMR1	NUFIP2	1.59677387818332	4.86249064999326e-06
BRCA	FMR1	CAPRIN1	1.61631170705267	5.15475086615707e-17
BRCA	FMR1	CYFIP1	-1.13433942711589	5.44928403979541e-07
KIRC	FMR1	TDRD3	1.02423146098262	6.53197063696712e-05
KICH	FMR1	EIF4E	1.61675210562671	6.55651092529297e-06
KIRC	FMR1	FXR1	-1.91678508891597	7.23860956542035e-06
LUAD	FMR1	FXR1	-1.55340065062105	7.61068774930263e-05

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with FMR1

UBE2I, FXR1, NUFIP1, NUFIP2, CYFIP2, FXR2, CYFIP1, FMR1, NCL, PRKAA1, STAU1, CALCOCO2, ZBP1, TBKBP1, TBK1, SIRT7, TDRD3, gag, ESR1, MAGOH, EIF4A3, BAG3, POTEE, RANBP9, INCA1, MEOX1, SPAG5, FSD2, STUB1, SUZ12, BCL7B, KBTBD2, WBP2NL, NTRK1, NCK1, IFI16, FZR1, SSX2IP, GBA, RPL10, SNCA, BCLAF1, THOC1, UBA6, MZT1, Kif5b, Stmn1, Mtx1, Sart3, Tubg1, Dennd6a, Bag2, Ccdc9, FBXW7, WWP2, LGALS3BP, CYLD, DLD, DLST, PDHA1, G3BP1, FBXO4, CLEC14A, HIF1AN, WDR77, TRIP4, GSK3A, AKAP9, RBM14, CASK, SF3B2, TNIP2, CHD3, CHD4, EZH2, HABP4, MB21D1, RNF41, C1orf106, PHF1, ATG16L1, USP14, KRAS, HIST1H4A, SNRNP70, BRD7, CTNNB1, EIF4E, ATG5, EFHC1, SUOX, POLR1C, ZBTB42, CWC25, PLEKHA4, FANCD2, HCVgp1, TCOF1, N, nsp9, nsp3, LIMS1, CAPRIN1, CSDE1, DAZL, DDX3X, AHNAK, ALG13, ANKHD1-EIF4EBP3, ANKRD17, ATXN2, DHX57, EIF4ENIF1, FAM120A, FUBP3, G3BP2, IGF2BP2, LSM12, LSM14A, MOV10, OTUD4, PRMT1, PRRC2A, PRRC2B, PRRC2C, R3HDM1, RC3H1, RC3H2, SMG1, STRAP, TNRC6B, TOP3B, UBAP2, UBAP2L, UPF1, USP10, YTHDF1, YTHDF2, ZC3H7A, AGO2, ATXN2L, C1QBP, CASC3, CPEB4, ERH, LARP4, LUZP1, MIA3, PUM1, PUM2, SMG7, YTHDF3, ZNF598, TRIM56, UNK, ZC3HAV1, TUBB3, CHTOP, GLE1, MEX3A, SECISBP2, MEX3B, ZC3H7B, LARP4B, RBMS1, RNF214, SYNCRIP, SMG8, MKRN2, ANLN, AURKB, ECT2, KIF14, KIF20A, KIF23, PRC1, CECR2, GRSF1, MKI67, BRD4, NUPR1, RBM39, TAF9B, CUX1, DKC1, VANGL2, IGF2BP3, HMBOX1, ACOT7, TUBB6, WNT5A, CWC15, IGF2BP1, DHX9, PLRG1, WTAP, MAGED1, PNN, PSMD3, EEF1A2, VANGL1, EIF4G1, TAF8, ADAR, NR3C1, TPD52L2, RBBP6, UFL1, DDRGK1, FBL, RPS20, SERBP1, TLE4, ALDOC, BEX4, CAMK2B, DCTPP1, DGKD, GRIP2, HOMER3, CCAR2, MAGI3, MVP, NECAB2, PICK1, PPP1R12C, PSME3, SFPQ, SHARPIN, TACC2, ZFPM2, ZMYND8, ZBTB2, CDX1, CD6, MAP7, ZBTB3, C1orf35, USP11, BTF3, TMPRSS2, IFITM1, DPP4, IFITM3, CLEC4D, CLEC4E, nsp1, nsp12, nsp15, nsp5, ORF10, nsp14, ORF3a, AGO1, HECTD1, SIRT6,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
FMR1	chrX	146993405	T	C	single_nucleotide_variant	Uncertain_significance	not_provided
FMR1	chrX	146993567	C	CGCG	Microsatellite	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
FMR1	chrX	146993567	C	CGCGGCG	Microsatellite	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
FMR1	chrX	146993567	C	CGCGGCGGCG	Microsatellite	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
FMR1	chrX	146993567	C	CGCGGCGGCGGCG	Microsatellite	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
FMR1	chrX	146993567	C	CGCGGCGGCGGCGGCG	Microsatellite	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
FMR1	chrX	146993567	C	CGCGGCGGCGGCGGCGGCG	Microsatellite	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
FMR1	chrX	146993567	C	CGCGGCGGCGGCGGCGGCGGCG	Microsatellite	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
FMR1	chrX	146993567	C	CGCGGCGGCGGCGGCGGCGGCGGCG	Microsatellite	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
FMR1	chrX	146993567	C	CGCGGCGGCGGCGGCGGCGGCGGCGGCG	Microsatellite	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
FMR1	chrX	146993567	C	CGCGGCGGCGGCGGCGGCGGCGGCGGCGGCG	Microsatellite	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
FMR1	chrX	146993567	C	CGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCG	Microsatellite	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
FMR1	chrX	146993567	C	CGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCG	Microsatellite	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
FMR1	chrX	146993567	C	CGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCG	Microsatellite	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
FMR1	chrX	146993567	C	CGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCG	Microsatellite	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
FMR1	chrX	146993567	C	CGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCG	Microsatellite	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
FMR1	chrX	146993567	C	CGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCG	Microsatellite	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
FMR1	chrX	146993567	C	CGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCG	Microsatellite	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
FMR1	chrX	146993567	C	CGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCG	Microsatellite	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
FMR1	chrX	146993567	C	CGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCG	Microsatellite	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
FMR1	chrX	146993567	C	CGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCG	Microsatellite	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
FMR1	chrX	146993567	C	CGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCG	Microsatellite	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
FMR1	chrX	146993567	C	CGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCG	Microsatellite	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
FMR1	chrX	146993567	C	CGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCG	Microsatellite	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
FMR1	chrX	146993567	C	CGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCG	Microsatellite	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
FMR1	chrX	146993567	C	CGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCG	Microsatellite	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
FMR1	chrX	146993567	C	CGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCG	Microsatellite	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
FMR1	chrX	146993567	C	CGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCG	Microsatellite	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
FMR1	chrX	146993567	C	CGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCG	Microsatellite	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
FMR1	chrX	146993567	C	CGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCG	Microsatellite	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
FMR1	chrX	146993567	C	CGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCG	Microsatellite	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
FMR1	chrX	146993567	C	CGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCG	Microsatellite	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
FMR1	chrX	146993567	C	CGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCG	Microsatellite	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
FMR1	chrX	146993567	C	CGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCG	Microsatellite	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
FMR1	chrX	146993567	C	CGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCG	Microsatellite	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
FMR1	chrX	146993567	CGCG	C	Microsatellite	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
FMR1	chrX	146993567	CGCGGCG	C	Microsatellite	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
FMR1	chrX	146993567	CGCGGCGGCG	C	Microsatellite	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
FMR1	chrX	146993567	CGCGGCGGCGGCG	C	Microsatellite	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
FMR1	chrX	146993567	CGCGGCGGCGGCGGCG	C	Microsatellite	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
FMR1	chrX	146993569	CGGCGGCGGCGGCGGCGGCGGCGGCGGCGG	.	Microsatellite	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0002073\|no_sequence_alteration	SO:0001619\|non-coding_transcript_variant,SO:0002073\|no_sequence_alteration
FMR1	chrX	146993599	A	AGGC	Microsatellite	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001623\|5_prime_UTR_variant
FMR1	chrX	146993715	G	T	single_nucleotide_variant	Benign	History_of_neurodevelopmental_disorder\|not_specified	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
FMR1	chrX	147003339	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
FMR1	chrX	147003450	GG	TA	Indel	Pathogenic	Fragile_X_syndrome	SO:0001574\|splice_acceptor_variant	SO:0001574\|splice_acceptor_variant
FMR1	chrX	147003470	A	G	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
FMR1	chrX	147003479	C	A	single_nucleotide_variant	Pathogenic	Fragile_X_syndrome	SO:0001587\|nonsense,SO:0001619\|non-coding_transcript_variant	SO:0001587\|nonsense,SO:0001619\|non-coding_transcript_variant
FMR1	chrX	147003500	A	G	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
FMR1	chrX	147003501	CAAGT	C	Microsatellite	Likely_pathogenic	not_provided	SO:0001575\|splice_donor_variant	SO:0001575\|splice_donor_variant
FMR1	chrX	147003508	G	C	single_nucleotide_variant	Likely_pathogenic	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
FMR1	chrX	147003545	A	G	single_nucleotide_variant	Benign	not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
FMR1	chrX	147003564	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
FMR1	chrX	147003794	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
FMR1	chrX	147007220	T	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
FMR1	chrX	147009838	A	G	single_nucleotide_variant	Likely_pathogenic	Autistic_behavior\|Intellectual_disability	SO:0001574\|splice_acceptor_variant	SO:0001574\|splice_acceptor_variant
FMR1	chrX	147009866	G	A	single_nucleotide_variant	Likely_benign	not_specified	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
FMR1	chrX	147010158	A	G	single_nucleotide_variant	Benign	not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
FMR1	chrX	147010210	A	G	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
FMR1	chrX	147010254	T	C	single_nucleotide_variant	Benign	not_specified	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
FMR1	chrX	147010263	A	C	single_nucleotide_variant	Likely_benign	Fragile_X_syndrome	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
FMR1	chrX	147010278	TA	T	Deletion	Pathogenic	Fragile_X_syndrome	SO:0001589\|frameshift_variant,SO:0001619\|non-coding_transcript_variant	SO:0001589\|frameshift_variant,SO:0001619\|non-coding_transcript_variant
FMR1	chrX	147010280	C	T	single_nucleotide_variant	Uncertain_significance	not_specified	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
FMR1	chrX	147010281	T	C	single_nucleotide_variant	Likely_benign	not_specified\|not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
FMR1	chrX	147010320	G	A	single_nucleotide_variant	Benign	Fragile_X_syndrome\|History_of_neurodevelopmental_disorder\|not_specified\|not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
FMR1	chrX	147010368	T	C	single_nucleotide_variant	Benign	not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
FMR1	chrX	147010529	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
FMR1	chrX	147011181	CC	.	Deletion	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
FMR1	chrX	147011445	A	AT	Duplication	Benign	not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
FMR1	chrX	147011457	A	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
FMR1	chrX	147011459	A	G	single_nucleotide_variant	Pathogenic	Intellectual_disability	SO:0001627\|intron_variant	SO:0001627\|intron_variant
FMR1	chrX	147011480	G	T	single_nucleotide_variant	Benign	Fragile_X_syndrome\|History_of_neurodevelopmental_disorder\|not_specified	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
FMR1	chrX	147011487	A	G	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
FMR1	chrX	147011526	C	T	single_nucleotide_variant	Likely_benign	Intellectual_disability	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
FMR1	chrX	147011655	T	A	single_nucleotide_variant	Likely_benign	not_specified	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
FMR1	chrX	147011687	T	C	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
FMR1	chrX	147011735	G	C	single_nucleotide_variant	Uncertain_significance	Inborn_genetic_diseases	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
FMR1	chrX	147011739	TGAA	T	Microsatellite	Uncertain_significance	Neurodevelopmental_abnormality	SO:0001619\|non-coding_transcript_variant,SO:0001822\|inframe_deletion	SO:0001619\|non-coding_transcript_variant,SO:0001822\|inframe_deletion
FMR1	chrX	147013964	G	A	single_nucleotide_variant	Likely_benign	History_of_neurodevelopmental_disorder	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
FMR1	chrX	147014110	G	A	single_nucleotide_variant	Likely_pathogenic	History_of_neurodevelopmental_disorder	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
FMR1	chrX	147014145	C	T	single_nucleotide_variant	Benign	not_specified\|not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
FMR1	chrX	147014220	A	G	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	Fragile_X_syndrome\|not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
FMR1	chrX	147014268	C	T	single_nucleotide_variant	Likely_pathogenic	See_cases	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
FMR1	chrX	147014521	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
FMR1	chrX	147017929	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
FMR1	chrX	147018053	T	A	single_nucleotide_variant	Pathogenic	Fragile_X_syndrome	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
FMR1	chrX	147018133	G	A	single_nucleotide_variant	Pathogenic	Intellectual_disability	SO:0001575\|splice_donor_variant	SO:0001575\|splice_donor_variant
FMR1	chrX	147018146	C	T	single_nucleotide_variant	Benign	not_specified\|not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
FMR1	chrX	147018273	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
FMR1	chrX	147019049	A	G	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
FMR1	chrX	147019192	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
FMR1	chrX	147019676	G	A	single_nucleotide_variant	Likely_pathogenic	Fragile_X_syndrome	SO:0001587\|nonsense,SO:0001619\|non-coding_transcript_variant,SO:0001627\|intron_variant	SO:0001587\|nonsense,SO:0001619\|non-coding_transcript_variant,SO:0001627\|intron_variant
FMR1	chrX	147019774	G	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
FMR1	chrX	147022162	A	G	single_nucleotide_variant	Likely_pathogenic	not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
FMR1	chrX	147022284	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
FMR1	chrX	147024558	A	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
FMR1	chrX	147024657	G	C	single_nucleotide_variant	Uncertain_significance	Fragile_X_syndrome	SO:0001583\|missense_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001627\|intron_variant
FMR1	chrX	147024707	T	A	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant
FMR1	chrX	147024746	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant
FMR1	chrX	147024783	G	A	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001627\|intron_variant
FMR1	chrX	147024838	A	G	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001627\|intron_variant
FMR1	chrX	147025868	C	G	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
FMR1	chrX	147026266	G	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
FMR1	chrX	147026489	C	T	single_nucleotide_variant	Benign/Likely_benign	Fragile_X_syndrome\|History_of_neurodevelopmental_disorder\|not_specified\|not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
FMR1	chrX	147026497	G	A	single_nucleotide_variant	Uncertain_significance	Inborn_genetic_diseases	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
FMR1	chrX	147026581	T	A	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
FMR1	chrX	147027062	G	A	single_nucleotide_variant	Uncertain_significance	History_of_neurodevelopmental_disorder	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
FMR1	chrX	147027125	G	A	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
FMR1	chrX	147027144	C	A	single_nucleotide_variant	Likely_benign	not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
FMR1	chrX	147030216	G	A	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
FMR1	chrX	147030322	C	T	single_nucleotide_variant	Benign/Likely_benign	History_of_neurodevelopmental_disorder\|not_specified\|not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
FMR1	chrX	147031110	T	C	single_nucleotide_variant	Benign	Fragile_X_syndrome	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
FMR1	BRCA	chrX	147026442	147026442	G	A	Missense_Mutation	p.E509K	4
FMR1	LGG	chrX	147014240	147014240	G	A	Missense_Mutation	p.E280K	3
FMR1	ESCA	chrX	147011714	147011714	C	G	Missense_Mutation	p.T194S	3
FMR1	UCEC	chrX	147018097	147018097	G	A	Missense_Mutation	p.E319K	3
FMR1	UCEC	chrX	147026502	147026502	G	T	Nonsense_Mutation	p.G529*	3
FMR1	UCEC	chrX	147030285	147030285	C	T	Missense_Mutation	p.T607M	3
FMR1	BRCA	chrX	147014261	147014261	C	G	Missense_Mutation	p.Q287E	3
FMR1	BRCA	chrX	147024827	147024827	C	T	Silent	p.R484	3
FMR1	LGG	chrX	147014219	147014219	A	-	Frame_Shift_Del	p.K274fs	3
FMR1	BRCA	chrX	147026507	147026507	C	T	Silent	p.D530	3
FMR1	UCEC	chrX	147024819	147024819	G	A	Missense_Mutation	p.G482S	3
FMR1	KIRP	chrX	147013951	147013951	G	T	Missense_Mutation		2
FMR1	SARC	chrX	147018109	147018109	G	A	Missense_Mutation	p.E323K	2
FMR1	STAD	chrX	147009864	147009864	G	C	Missense_Mutation		2
FMR1	UCEC	chrX	147014094	147014094	A	G	Missense_Mutation	p.T261A	2
FMR1	DLBC	chrX	146993715	146993715	G	T	Silent	p.V6V	2
FMR1	LIHC	chrX	147018112	147018112	A	-	Frame_Shift_Del	p.K324fs	2
FMR1	UCEC	chrX	147030296	147030296	C	T	Missense_Mutation	p.R611C	2
FMR1	BLCA	chrX	147014278	147014278	A	G	Silent	p.L292L	2
FMR1	LUAD	chrX	147009854	147009854	A	T	Silent	p.A71A	2
FMR1	LGG	chrX	147010283	147010283	T	C	Missense_Mutation	p.F126S	2
FMR1	STAD	chrX	147009864	147009864	G	C	Missense_Mutation	p.E75Q	2
FMR1	UCEC	chrX	147014233	147014233	C	A	Missense_Mutation	p.S277R	2
FMR1	ESCA	chrX	147010265	147010265	C	A	Missense_Mutation	p.P120H	2
FMR1	LIHC	chrX	147030221	147030221	A	-	Frame_Shift_Del	p.N565fs	2
FMR1	UCEC	chrX	147030348	147030348	T	C	Missense_Mutation	p.V628A	2
FMR1	UCEC	chrX	147024699	147024699	C	T	Nonsense_Mutation	p.R442*	2
FMR1	SKCM	chrX	147019005	147019005	C	T	Silent	p.S337S	2
FMR1	STAD	chrX	147010200	147010200	A	G	Silent	p.A98A	2
FMR1	UCEC	chrX	147014238	147014238	T	C	Missense_Mutation	p.L279P	2
FMR1	BRCA	chrX	147007128	147007128	A	C	Missense_Mutation	p.I59L	2
FMR1	HNSC	chrX	147014272	147014272	G	T	Missense_Mutation	p.R290S	2
FMR1	SKCM	chrX	147022103	147022103	A	G	Silent	p.V378V	2
FMR1	UCEC	chrX	147018105	147018105	A	C	Missense_Mutation	p.E321D	2
FMR1	UCS	chrX	147030228	147030228	G	T	Nonsense_Mutation	p.G498*	2
FMR1	BRCA	chrX	147027089	147027089	C	G	Missense_Mutation	p.R564G	2
FMR1	LUAD	chrX	147024827	147024827	C	A	Silent	p.R463R	2
FMR1	STAD	chrX	147007065	147007065	C	G	Missense_Mutation	p.P38A	2
FMR1	UCEC	chrX	147022171	147022171	A	C	Missense_Mutation	p.N422T	2
FMR1	ESCA	chrX	147011714	147011714	C	G	Missense_Mutation		2
FMR1	SKCM	chrX	147019652	147019652	C	T	Missense_Mutation	p.S387F	2
FMR1	UCEC	chrX	147024667	147024667	G	A	Missense_Mutation	p.R431H	2
FMR1	KICH	chrX	147011711	147011711	G	A	Missense_Mutation	p.R193H	2
FMR1	STAD	chrX	147011748	147011748	T	G	Silent	p.A205A	2
FMR1	UCEC	chrX	147024799	147024799	C	T	Missense_Mutation	p.P475L	2
FMR1	STAD	chrX	147024689	147024689	T	C	Silent	p.D438D	2
FMR1	UCEC	chrX	147026511	147026511	C	T	Missense_Mutation	p.R532W	2
FMR1	LUAD	chrX	147011469	147011469	G	T	Missense_Mutation	p.C141F	2
FMR1	SARC	chrX	147018109	147018109	G	A	Missense_Mutation		2
FMR1	UCEC	chrX	147010244	147010244	G	A	Missense_Mutation	p.R113K	2
FMR1	KIRP	chrX	147011651	147011651	T	A	Missense_Mutation	p.I173N	2
FMR1	LGG	chrX	147010283	147010283	T	C	Missense_Mutation		2
FMR1	STAD	chrX	147009866	147009866	G	A	Silent	p.E75E	2
FMR1	UCEC	chrX	147026530	147026530	G	A	Missense_Mutation	p.G538E	2
FMR1	UCEC	chrX	147014005	147014005	G	A	Missense_Mutation	p.G231D	2
FMR1	CESC	chrX	147014007	147014007	C	G	Missense_Mutation		2
FMR1	LIHC	chrX	147003459	147003459	A	-	Frame_Shift_Del	p.V20fs	2
FMR1	STAD	chrX	147011719	147011719	T	G	Missense_Mutation	p.L196V	2
FMR1	UCEC	chrX	147027072	147027072	G	A	Missense_Mutation	p.R558Q	2
FMR1	PAAD	chrX	147024736	147024736	G	A	Missense_Mutation		2
FMR1	CESC	chrX	147027065	147027065	C	T	Missense_Mutation		2
FMR1	LUAD	chrX	147011491	147011491	G	T	Missense_Mutation	p.K148N	2
FMR1	SKCM	chrX	147026416	147026416	C	T	Missense_Mutation	p.S479F	2
FMR1	UCEC	chrX	147014062	147014062	T	C	Missense_Mutation	p.V250A	2
FMR1	LIHC	chrX	147009859	147009859	A	-	Frame_Shift_Del	p.E73fs	2
FMR1	STAD	chrX	147019098	147019098	T	C	Silent	p.P368P	2
FMR1	UCEC	chrX	147027130	147027130	C	T	Silent	p.S577	2
FMR1	LUAD	chrX	147011477	147011477	G	T	Nonsense_Mutation	p.E144*	2
FMR1	PAAD	chrX	147026464	147026464	C	A	Missense_Mutation		2
FMR1	CESC	chrX	147011666	147011666	C	G	Missense_Mutation		1
FMR1	LUAD	chrX	147026524	147026524	G	T	Missense_Mutation	p.G515V	1
FMR1	LIHC	chrX	147018098	147018098	A	G	Missense_Mutation		1
FMR1	LUSC	chrX	147018994	147018994	C	T	Missense_Mutation	p.P334S	1
FMR1	STAD	chrX	147027084	147027084	G	A	Missense_Mutation	p.R562H	1
FMR1	UCEC	chrX	147019078	147019078	A	G	Missense_Mutation	p.S362G	1
FMR1	HNSC	chrX	147018994	147018994	C	T	Missense_Mutation		1
FMR1	PAAD	chrX	147024736	147024736	G	A	Missense_Mutation	p.R433H	1
FMR1	CESC	chrX	147027065	147027065	C	T	Missense_Mutation	p.H556Y	1
FMR1	LUAD	chrX	147011749	147011749	A	T	Missense_Mutation	p.S206C	1
FMR1	SARC	chrX	147007125	147007125	G	T	Missense_Mutation	p.D58Y	1
FMR1	LIHC	chrX	147024653	147024653	A	G	Silent		1
FMR1	LUSC	chrX	147024736	147024736	G	C	Missense_Mutation	p.R454P	1
FMR1	STAD	chrX	147026475	147026475	G	A	Missense_Mutation	p.E520K	1
FMR1	BLCA	chrX	147024795	147024795	A	T	Nonsense_Mutation	p.R453*	1
FMR1	HNSC	chrX	147026445	147026445	C	T	Missense_Mutation	p.L489F	1
FMR1	LUAD	chrX	147030276	147030276	G	T	Missense_Mutation	p.R583L	1
FMR1	PAAD	chrX	147026464	147026464	C	A	Missense_Mutation	p.A495D	1
FMR1	CESC	chrX	147011666	147011666	C	G	Nonsense_Mutation	p.S178*	1
FMR1	LUAD	chrX	147007065	147007065	C	A	Missense_Mutation	p.P38T	1
FMR1	LIHC	chrX	147018119	147018119	T	C	Missense_Mutation		1
FMR1	LIHC	chrX	147026523	147026523	G	-	Frame_Shift_Del	p.G517fs	1
FMR1	LUSC	chrX	147030327	147030327	T	A	Missense_Mutation	p.V621E	1
FMR1	STAD	chrX	147010315	147010315	T	C	Silent	p.L137L	1
FMR1	UCS	chrX	147030228	147030228	G	T	Nonsense_Mutation	p.G498X	1
FMR1	LUAD	chrX	147027066	147027066	A	T	Missense_Mutation	p.H535L	1
FMR1	PAAD	chrX	147024736	147024736	G	A	Missense_Mutation	p.R454H	1
FMR1	COAD	chrX	147010268	147010268	C	T	Missense_Mutation	p.A121V	1
FMR1	LGG	chrX	147026457	147026457	T	C	Missense_Mutation	p.S493P	1
FMR1	LUAD	chrX	147014252	147014252	G	A	Translation_Start_Site		1
FMR1	STAD	chrX	147007109	147007115	TGTAGGT	-	Frame_Shift_Del	p.52_54del	1
FMR1	ESCA	chrX	147010265	147010265	C	A	Missense_Mutation		1
FMR1	LIHC	chrX	147014260	147014260	A	-	Frame_Shift_Del		1
FMR1	LIHC	chrX	147018099	147018099	G	-	Frame_Shift_Del	p.E319fs	1
FMR1	LUSC	chrX	147011672	147011672	G	T	Missense_Mutation	p.R180L	1
FMR1	STAD	chrX	147030286	147030286	G	A	Silent	p.T607T	1
FMR1	HNSC	chrX	147026445	147026445	C	T	Missense_Mutation	p.L510F	1
FMR1	PAAD	chrX	147026464	147026464	C	A	Missense_Mutation	p.A516D	1
FMR1	COAD	chrX	147010320	147010320	G	A	Silent	p.R138R	1
FMR1	LGG	chrX	147013976	147013976	A	G	Silent	p.E221E	1
FMR1	LUAD	chrX	147011726	147011728	TGA	-	In_Frame_Del	p.LI198del	1
FMR1	STAD	chrX	147010206	147010206	T	C	Silent	p.D100D	1
FMR1	LIHC	chrX	147011692	147011692	A	T	Missense_Mutation	p.M187L	1
FMR1	LIHC	chrX	147018104	147018104	A	-	Frame_Shift_Del	p.E321fs	1
FMR1	MESO	chrX	147027061	147027061	C	A	Missense_Mutation		1
FMR1	LUAD	chrX	147019024	147019024	A	G	Missense_Mutation	p.R344G	1
FMR1	PRAD	chrX	147024667	147024667	G	A	Missense_Mutation	p.R410H	1
FMR1	KICH	chrX	147011711	147011711	G	A	Missense_Mutation		1
FMR1	COAD	chrX	147014110	147014110	G	A	Missense_Mutation	p.G266E	1
FMR1	LGG	chrX	147014218	147014219	-	A	Frame_Shift_Ins	p.VK272fs	1
FMR1	LUAD	chrX	147027066	147027066	A	T	Missense_Mutation	p.H556L	1
FMR1	STAD	chrX	147030286	147030286	G	A	Missense_Mutation	p.R517Q	1
FMR1	STAD	chrX	147007109	147007115	TGTAGGT	-	Frame_Shift_Del	p.P52fs	1
FMR1	ESCA	chrX	146993710	146993710	G	T	Missense_Mutation	p.V5L	1
FMR1	LIHC	chrX	147014058	147014058	G	-	Frame_Shift_Del	p.G249fs	1
FMR1	MESO	chrX	147011702	147011702	G	T	Missense_Mutation		1
FMR1	LUAD	chrX	147014083	147014083	A	T	Translation_Start_Site		1
FMR1	READ	chrX	147011728	147011728	A	G	Missense_Mutation	p.I199V	1
FMR1	SKCM	chrX	147013963	147013963	C	T	Missense_Mutation	p.S217L	1
FMR1	UCEC	chrX	147018035	147018036	-	A	Frame_Shift_Ins	p.G298fs	1
FMR1	COAD	chrX	147018134	147018134	T	C	Splice_Site	.	1
FMR1	LGG	chrX	147026489	147026489	C	-	Frame_Shift_Del	p.S503fs	1
FMR1	LIHC	chrX	147014109	147014109	G	A	Missense_Mutation	p.G266R	1
FMR1	LUAD	chrX	147014083	147014083	A	T	Missense_Mutation	p.E257V	1
FMR1	THCA	chrX	147026458	147026458	C	T	Missense_Mutation		1
FMR1	ESCA	chrX	147030224	147030224	G	T	Nonsense_Mutation	p.E587X	1
FMR1	LIHC	chrX	147010230	147010230	A	-	Frame_Shift_Del	p.T108fs	1
FMR1	OV	chrX	147024700	147024700	G	A	Missense_Mutation	p.R442Q	1
FMR1	LUAD	chrX	147018985	147018985	G	C	Splice_Site	p.E331_splice	1
FMR1	SARC	chrX	147019079	147019079	G	T	Missense_Mutation		1
FMR1	SKCM	chrX	147011492	147011492	G	A	Missense_Mutation	p.D149N	1
FMR1	UCEC	chrX	147019049	147019049	A	-	Frame_Shift_Del	p.E352fs	1
FMR1	KIRC	chrX	147014114	147014114	G	T	Missense_Mutation	p.E267D	1
FMR1	COAD	chrX	147024749	147024749	A	G	Silent	p.E437E	1
FMR1	LIHC	chrX	147014260	147014260	A	-	Frame_Shift_Del	p.I286fs	1
FMR1	LUAD	chrX	147018985	147018985	G	C	Missense_Mutation	p.E331Q	1
FMR1	THCA	chrX	147026458	147026458	C	T	Missense_Mutation	p.S514L	1
FMR1	ACC	chrX	147030346	147030346	C	A	Nonsense_Mutation	p.S537X	1
FMR1	ESCA	chrX	147011476	147011476	A	G	Silent	p.K143K	1
FMR1	LIHC	chrX	147022111	147022111	T	-	Frame_Shift_Del	p.V381fs	1
FMR1	OV	chrX	146837974	146837974	G	A	Missense_Mutation	p.R606H	1
FMR1	SKCM	chrX	147010284	147010284	C	T	Silent	p.F126F	1
FMR1	COAD	chrX	147030282	147030282	G	A	Missense_Mutation	p.A495T	1
FMR1	LIHC	chrX	147019644	147019645	-	G	Frame_Shift_Ins	p.AG384fs	1
FMR1	LUAD	chrX	147026523	147026524	GG	AT	Missense_Mutation	p.G536M	1
FMR1	THCA	chrX	147026458	147026458	C	T	Missense_Mutation	p.S493L	1
FMR1	ACC	chrX	147030346	147030346	C	A	Nonsense_Mutation	p.S516X	1
FMR1	GBM	chrX	147003463	147003463	G	T	Missense_Mutation		1
FMR1	LUAD	chrX	147024765	147024765	G	T	Missense_Mutation	p.D443Y	1
FMR1	OV	chrX	147009912	147009912	G	T	Splice_Site	e4+1	1
FMR1	LUAD	chrX	147026523	147026523	G	A	Missense_Mutation	p.G515R	1
FMR1	SARC	chrX	147007125	147007125	G	T	Missense_Mutation		1
FMR1	SKCM	chrX	147024747	147024747	G	A	Missense_Mutation	p.E437K	1
FMR1	KIRP	chrX	147014033	147014033	T	C	Silent	p.N240N	1
FMR1	COAD	chrX	147024825	147024825	C	T	Missense_Mutation	p.R463C	1
FMR1	LGG	chrX	147013976	147013976	A	G	Missense_Mutation		1
FMR1	LUSC	chrX	147024824	147024824	A	G	Silent	p.R483R	1
FMR1	THYM	chrX	147007068	147007068	G	T	Missense_Mutation	p.D39Y	1
FMR1	ACC	chrX	147030346	147030346	C	A	Nonsense_Mutation	p.S537*	1
FMR1	HNSC	chrX	147022094	147022094	G	T	Splice_Site		1
FMR1	LUAD	chrX	147010237	147010237	C	T	Missense_Mutation	p.R111C	1
FMR1	KIRP	chrX	147030261	147030261	C	A	Missense_Mutation		1
FMR1	SARC	chrX	146993706	146993706	G	T	Missense_Mutation		1
FMR1	COAD	chrX	147030281	147030281	C	T	Missense_Mutation	p.R560C	1
FMR1	LGG	chrX	147026457	147026457	T	C	Missense_Mutation		1
FMR1	LUSC	chrX	147009842	147009842	G	T	Silent	p.V67V	1
FMR1	BLCA	chrX	147014278	147014278	A	G	Silent		1
FMR1	HNSC	chrX	147014059	147014059	G	T	Missense_Mutation		1

Copy number variation (CNV) of FMR1
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across FMR1
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
82717	N/A	CV404864	ECHDC2	chr1	53380619	+	FMR1	chrX	147002462	-
30785	LGG	TCGA-CS-4942-01A	FMR1	chrX	147003503	+	AFF2	chrX	147733520	+
77429	OV	TCGA-23-2081	FMR1	chrX	146993748	+	ATRX	chrX	76829823	-
102918	HNSC	TCGA-CV-A45U	FMR1	chrX	146993748	+	FIP1L1	chr4	54265896	+
92750	LUSC	TCGA-37-4133	FMR1	chrX	146993748	+	GPC3	chrX	132730627	-
63369	STAD	TCGA-VQ-AA6G	FMR1	chrX	146993748	+	MTM1	chrX	149826293	+
69503	STAD	TCGA-CG-5721	FMR1	chrX	146993748	+	NDUFS6	chr5	1814452	+
85668	N/A	EC574309	FMR1	chrX	146998088	+	SPECC1L-ADORA2A	chr22	24811977	-
82717	N/A	BF083070	HN1L	chr16	1749663	+	FMR1	chrX	147027136	-
82717	N/A	AW801819	NAA25	chr12	112488811	-	FMR1	chrX	147030915	+
82717	N/A	BE813282	SLC25A46	chr5	110100559	-	FMR1	chrX	147006742	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
SARC	FMR1	0.00297817046955348	0.08
LIHC	FMR1	0.0154640137618757	0.4
LGG	FMR1	0.0285614710890263	0.71
KIRC	FMR1	8.44537518932935e-06	0.00024

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRC	FMR1	0.0253038017359209	0.76
GBM	FMR1	0.0254863612540669	0.76
LGG	FMR1	0.0488725801175056	1
BRCA	FMR1	0.0232566564507372	0.74
ESCA	FMR1	0.0416917774945447	1
ACC	FMR1	0.023843536961698	0.74
SARC	FMR1	0.0217665434563008	0.72

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0016667	Fragile X Syndrome	37	CLINGEN;CTD_human;GENOMICS_ENGLAND;UNIPROT
C0751156	FRAXA Syndrome	8	CTD_human
C0751157	FRAXE Syndrome	8	CTD_human
C0004352	Autistic Disorder	5	CTD_human
C0020796	Profound Mental Retardation	2	CTD_human
C0036341	Schizophrenia	2	PSYGENET
C0041696	Unipolar Depression	2	PSYGENET
C0917816	Mental deficiency	2	CTD_human
C1269683	Major Depressive Disorder	2	PSYGENET
C1839780	FRAGILE X TREMOR/ATAXIA SYNDROME	2	CTD_human;GENOMICS_ENGLAND;ORPHANET
C0018051	Gonadal Dysgenesis	1	CTD_human
C0085215	Ovarian Failure, Premature	1	CTD_human
C0086367	Gonadotropin-Resistant Ovary Syndrome	1	CTD_human
C0338908	Mixed anxiety and depressive disorder	1	PSYGENET
C0376280	Anxiety States, Neurotic	1	CTD_human
C0949331	Gonadal Agenesis	1	CTD_human
C1279420	Anxiety neurosis (finding)	1	CTD_human
C3275521	CHROMOSOME Xq27.3-q28 DUPLICATION SYNDROME	1	ORPHANET
C3494522	Hypergonadotropic Ovarian Failure, X-Linked	1	CTD_human
C4552079	Premature Ovarian Failure 1	1	CTD_human;GENOMICS_ENGLAND