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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPL13A (NCBI Gene ID:23521)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPL13A
	Gene ID: 23521
	Gene Symbol	RPL13A
	Gene ID	23521
	Gene Name	ribosomal protein L13a
	Synonyms	L13A\|TSTA1
	Cytomap	19q13.33
	Type of Gene	protein-coding
	Description	60S ribosomal protein L13a23 kDa highly basic proteinepididymis secretory sperm binding proteinlarge ribosomal subunit protein uL13tissue specific transplantation antigen 1
	Modification date	20200313
	UniProtAcc	P40429

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0017148	Negative regulation of translation
GO:0006417	Regulation of translation
GO:0005840	Ribosome
GO:0002181	Cytoplasmic translation
GO:0006413	Translational initiation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RPL13A	GO:0017148	negative regulation of translation	14567916\|23071094
Hgene	RPL13A	GO:0071346	cellular response to interferon-gamma	15479637
Hgene	RPL13A	GO:1901194	negative regulation of formation of translation preinitiation complex	17218275

Inferred gene age of translation factor.

Gene

Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25

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Translation Studies in PubMed

We searched PubMed using 'RPL13A[title] AND translation [title] AND human.'

Gene	Title	PMID
RPL13A	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000391857	49993488	49993554	In-frame
ENST00000391857	49993731	49993833	In-frame
ENST00000391857	49994035	49994121	Frame-shift
ENST00000391857	49994296	49994356	In-frame
ENST00000391857	49994681	49994804	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000391857	49993488	49993554	1198	165	230	203	29	51
ENST00000391857	49993731	49993833	1198	231	332	203	51	85
ENST00000391857	49994296	49994356	1198	419	478	203	114	134
ENST00000391857	49994681	49994804	1198	479	601	203	134	175

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
P40429	51	85	2	203	Chain	ID=PRO_0000133769;Note=60S ribosomal protein L13a
P40429	134	175	2	203	Chain	ID=PRO_0000133769;Note=60S ribosomal protein L13a
P40429	114	134	2	203	Chain	ID=PRO_0000133769;Note=60S ribosomal protein L13a
P40429	29	51	2	203	Chain	ID=PRO_0000133769;Note=60S ribosomal protein L13a
P40429	51	85	59	59	Modified residue	Note=Citrulline;Ontology_term=ECO:0000250;evidence=ECO:0000250
P40429	51	85	77	77	Modified residue	Note=Phosphoserine%3B by ZIPK/DAPK3;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:18995835;Dbxref=PMID:18995835
P40429	134	175	140	140	Modified residue	Note=Citrulline;Ontology_term=ECO:0000250;evidence=ECO:0000250
P40429	51	85	77	77	Mutagenesis	Note=Loss of interferon-gamma induced phosphorylation. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:18995835;Dbxref=PMID:18995835

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
THCA	RPL13A	1.00055529557489	0.00121938003080576
KIRC	RPL13A	-2.22570045477256	1.02382991067149e-08

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
KIRC	RPL13A	-0.057409716	0.015432496

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPL13A (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
ACC	Epifactor	RPL13A	TRIM28	0.801001003	7.83E-19
ACC	IUPHAR	RPL13A	TRIM28	0.801001003	7.83E-19
ACC	Kinase	RPL13A	TRIM28	0.801001003	7.83E-19
ACC	TF	RPL13A	ZNF581	0.856195085	8.69E-24
ACC	TSG	RPL13A	GLTSCR2	0.876309338	3.89E-26
BLCA	TSG	RPL13A	GLTSCR2	0.835444497	2.74E-112
BRCA	TSG	RPL13A	GLTSCR2	0.806289426	1.47E-279
CESC	TSG	RPL13A	GLTSCR2	0.845678867	1.91E-85
CHOL	Epifactor	RPL13A	FBL	0.807774741	2.00E-11
CHOL	TF	RPL13A	ZNF581	0.835168687	9.82E-13
CHOL	TSG	RPL13A	GNB2L1	0.82997737	1.81E-12
CHOL	TSG	RPL13A	GLTSCR2	0.879846414	1.75E-15
DLBC	Cell metabolism gene	RPL13A	SNRPD2	0.81887381	1.15E-12
DLBC	CGC	RPL13A	NACA	0.812209354	2.44E-12
DLBC	Epifactor	RPL13A	FBL	0.821999438	7.97E-13
DLBC	TF	RPL13A	ZNF581	0.816716551	1.47E-12
DLBC	TSG	RPL13A	GNB2L1	0.894095348	1.17E-17
DLBC	TSG	RPL13A	GLTSCR2	0.916991042	5.55E-20
ESCA	TSG	RPL13A	GLTSCR2	0.838769814	4.11E-53
GBM	Cell metabolism gene	RPL13A	PFDN5	0.804494135	2.62E-40
HNSC	TSG	RPL13A	GLTSCR2	0.803247923	5.17E-129
KICH	Cell metabolism gene	RPL13A	SNRPD2	0.810350303	2.26E-22
KIRP	TF	RPL13A	ZNF581	0.828276415	9.49E-83
LAML	TSG	RPL13A	GNB2L1	0.802293906	3.65E-40
LAML	TSG	RPL13A	GLTSCR2	0.822457748	9.33E-44
LGG	Epifactor	RPL13A	FBL	0.847838198	1.38E-147
LGG	TSG	RPL13A	GLTSCR2	0.844842881	1.55E-145
LIHC	TSG	RPL13A	GLTSCR2	0.819840672	5.35E-104
MESO	TSG	RPL13A	GLTSCR2	0.856389692	3.98E-26
PCPG	Epifactor	RPL13A	FBL	0.826625004	4.55E-48
PCPG	TSG	RPL13A	GNB2L1	0.817049323	4.09E-46
PCPG	TSG	RPL13A	GLTSCR2	0.884191945	4.63E-63
PRAD	Cell metabolism gene	RPL13A	SNRPD2	0.801637628	1.53E-124
PRAD	Cell metabolism gene	RPL13A	NME2	0.802212587	7.53E-125
PRAD	Cell metabolism gene	RPL13A	TIMM9	0.808579375	2.51E-128
PRAD	CGC	RPL13A	NACA	0.827414683	1.98E-139
PRAD	Epifactor	RPL13A	FBL	0.862865266	1.60E-164
PRAD	TF	RPL13A	ZNF524	0.80080898	4.23E-124
PRAD	TF	RPL13A	NME2	0.802212587	7.53E-125
PRAD	TF	RPL13A	ZNF581	0.829642517	7.84E-141
PRAD	TSG	RPL13A	GNB2L1	0.906495717	2.33E-207
SKCM	TSG	RPL13A	GLTSCR2	0.827100361	3.48E-120
THCA	Cell metabolism gene	RPL13A	FAU	0.800679931	6.19E-129
THCA	Cell metabolism gene	RPL13A	SNRPD2	0.803082592	2.84E-130
THCA	Epifactor	RPL13A	FBL	0.815973524	8.89E-138
THCA	TSG	RPL13A	GNB2L1	0.843358886	6.99E-156
THYM	Cell metabolism gene	RPL13A	SLC27A5	0.806312657	3.86E-29
THYM	Cell metabolism gene	RPL13A	TIMM13	0.819707395	8.03E-31
THYM	Cell metabolism gene	RPL13A	PFDN5	0.822107337	3.88E-31
THYM	Cell metabolism gene	RPL13A	PGLS	0.823834967	2.28E-31
THYM	Cell metabolism gene	RPL13A	SNRPD2	0.82419389	2.04E-31
THYM	Cell metabolism gene	RPL13A	SSR2	0.832015816	1.70E-32
THYM	Cell metabolism gene	RPL13A	FAU	0.859711085	8.20E-37
THYM	Epifactor	RPL13A	C17orf49	0.804855196	5.78E-29
THYM	Epifactor	RPL13A	PRMT1	0.807839303	2.52E-29
THYM	Epifactor	RPL13A	NOC2L	0.810079492	1.34E-29
THYM	Epifactor	RPL13A	MBD3	0.815586328	2.73E-30
THYM	Epifactor	RPL13A	FBL	0.882838224	3.39E-41
THYM	IUPHAR	RPL13A	SLC27A5	0.806312657	3.86E-29
THYM	IUPHAR	RPL13A	PRMT1	0.807839303	2.52E-29
THYM	TF	RPL13A	THAP3	0.805008491	5.54E-29
THYM	TF	RPL13A	REXO4	0.810774875	1.10E-29
THYM	TF	RPL13A	MBD3	0.815586328	2.73E-30
THYM	TF	RPL13A	ZNF581	0.833128641	1.18E-32
THYM	TSG	RPL13A	TSSC4	0.830282488	2.99E-32
THYM	TSG	RPL13A	GNB2L1	0.835427504	5.54E-33
THYM	TSG	RPL13A	GLTSCR2	0.858674368	1.24E-36
UCS	Cell metabolism gene	RPL13A	SLC27A5	0.806312657	3.86E-29
UCS	Cell metabolism gene	RPL13A	TIMM13	0.819707395	8.03E-31
UCS	Cell metabolism gene	RPL13A	PFDN5	0.822107337	3.88E-31
UCS	Cell metabolism gene	RPL13A	PGLS	0.823834967	2.28E-31
UCS	Cell metabolism gene	RPL13A	SNRPD2	0.82419389	2.04E-31
UCS	Cell metabolism gene	RPL13A	SSR2	0.832015816	1.70E-32
UCS	Cell metabolism gene	RPL13A	FAU	0.859711085	8.20E-37
UCS	Epifactor	RPL13A	C17orf49	0.804855196	5.78E-29
UCS	Epifactor	RPL13A	PRMT1	0.807839303	2.52E-29
UCS	Epifactor	RPL13A	NOC2L	0.810079492	1.34E-29
UCS	Epifactor	RPL13A	MBD3	0.815586328	2.73E-30
UCS	Epifactor	RPL13A	FBL	0.882838224	3.39E-41
UCS	IUPHAR	RPL13A	SLC27A5	0.806312657	3.86E-29
UCS	IUPHAR	RPL13A	PRMT1	0.807839303	2.52E-29
UCS	TF	RPL13A	THAP3	0.805008491	5.54E-29
UCS	TF	RPL13A	REXO4	0.810774875	1.10E-29
UCS	TF	RPL13A	MBD3	0.815586328	2.73E-30
UCS	TF	RPL13A	ZNF581	0.833128641	1.18E-32
UCS	TSG	RPL13A	TSSC4	0.830282488	2.99E-32
UCS	TSG	RPL13A	GNB2L1	0.835427504	5.54E-33
UCS	TSG	RPL13A	GLTSCR2	0.858674368	1.24E-36
UVM	CGC	RPL13A	NACA	0.846420838	4.77E-23
UVM	Epifactor	RPL13A	FBL	0.821191819	1.08E-20
UVM	TSG	RPL13A	GNB2L1	0.819733588	1.44E-20
UVM	TSG	RPL13A	GLTSCR2	0.867059415	2.59E-25

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRP	RPL13A	RPL18A	-1.51651392808885	0.00016188295558095
KICH	RPL13A	RPS27A	1.75396693785956	0.000187873840332031
KIRP	RPL13A	RPS16	-1.35957043617517	0.00019507110118866
KIRP	RPL13A	RPS11	-1.01861570565103	0.00105937570333481
LIHC	RPL13A	RPL8	-4.84588284974558	0.00110314154326131
PRAD	RPL13A	RPL18A	1.40600175748499	0.00205137828390396
KICH	RPL13A	RPL19	1.36901182894089	0.00250792503356934
KICH	RPL13A	RPS12	1.26997381758431	0.00308787822723389
LUAD	RPL13A	RPL19	-1.31398026615725	0.00993159558412698
THCA	RPL13A	RPS16	-6.16322798156577	0.0115764821363307
BLCA	RPL13A	RPS12	-1.47804673440421	0.0204124450683594
BLCA	RPL13A	RPS27A	-1.04747470069188	0.0258216857910156
CHOL	RPL13A	GAPDH	-3.07354785261475	0.02734375
COAD	RPL13A	RPS11	1.35307548998204	0.0312207043170929
LUSC	RPL13A	RPL19	-2.14669889516666	0.044366810398747
BRCA	RPL13A	GAPDH	-1.37642902567885	1.15182974050406e-18
KIRC	RPL13A	RPL19	-2.73485271276676	1.33980982873695e-10
BRCA	RPL13A	RPS12	-4.91239327478244	1.85340619742495e-09
KIRP	RPL13A	RPL37	-1.17421621947139	2.26888805627823e-05
KIRC	RPL13A	RPL35	-1.06475238059392	2.72286325678163e-08
KIRC	RPL13A	RPL8	-1.18252459971773	5.64962994208288e-07
KIRP	RPL13A	RPL8	-1.53003692350119	6.0301274061203e-05
LUAD	RPL13A	GAPDH	-2.39625242862964	7.0750762948169e-11
KIRC	RPL13A	RPS16	-1.66149869889384	7.8509870430991e-09
BRCA	RPL13A	RPS27A	-4.28512148200424	7.8788217967112e-14
KIRC	RPL13A	RPL37	-2.87198822058464	8.03913394748564e-12
KIRP	RPL13A	RPL35	-1.52981101975496	9.0546440333128e-05
KIRC	RPL13A	RPL18A	-4.43079304960843	9.2516163152192e-11

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPL13A

GOLM1, NOP56, CALM1, NFX1, CUL3, CUL5, CUL1, CAND1, ESR1, MAGOH, EIF4A3, FN1, VCAM1, TP63, UBL4A, ITGA4, PAN2, IGSF8, ICAM1, CRP, ALG12, STOM, ALDH2, CYP2E1, FNTA, ND1, RPL30, VTN, ETS1, TARDBP, Erbb3, RPA3, RPA2, RPA1, ZBTB1, CEP250, TUBG1, HUWE1, CCDC8, EED, RNF2, RPL14, RPL8, NIFK, THAP7, ZC3H3, PRR11, NTRK1, EIF6, FBL, PABPC1, PABPC4, POLR1C, RPL10, RPL10A, RPL11, RPL12, HSPA8, RPL13, RPL18, RPL18A, RPL19, RPL21, RPL22, RPL23, RPL23A, RPL24, RPL27, RPL3, RPL31, RPL34, RPL35, RPL36, RPL38, RPL7, RPLP0, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS19, RPS2, RPS20, RPS23, RPS25, RPS3, RPS3A, RPS5, RPS8, RPS9, RPSA, SEC61A1, RPL15, RPL17, RPL27A, RPL32, RPL35A, RPL37A, RPL4, RPL5, RPL6, RPL7A, RPL9, RPLP2, RPS14, RPS18, LOC101929876, RPS26, RPS27, RPS4X, RPS6, RPS7, PTEN, HNRNPU, NPM1, Eif3a, Eif3e, Ktn1, Rpl35, Srp72, Rrbp1, MCM2, NF2, ZNF746, RRS1, CNBP, SART3, RBM34, KIAA0020, NCL, CYLD, PDHA1, FOXA1, TRIM25, YAP1, PPP1CC, API5, WDR77, PCBP1, PRPF8, EFTUD2, AAR2, PIH1D1, TNIP2, TNF, FAM188B, RIOK1, NOD2, MEPCE, LARP7, SNAI1, AGR2, RECQL4, REST, MYC, HIST1H3A, GRWD1, RC3H1, RC3H2, PHB, RBX1, USP14, NR2C2, CTCF, VRK1, HIST1H4A, SNRNP70, Dppa3, ITFG1, HMGB1, BIRC3, STAU1, WWP2, MATR3, Dnajc17, CMTR1, ARIH2, FANCD2, NGB, HCVgp1, ZC3H18, GRB7, MAP3K14, PTPN6, RAB5A, GPR116, TOMM70A, TET3, E, M, nsp13, nsp4, nsp5, nsp6, ORF3a, ORF7a, ORF7b, CIT, ANLN, AURKB, CHMP4C, ECT2, KIF14, MAD2L2, KIF20A, KIF23, PRC1, GRSF1, MCU, MKI67, NDN, Rnf183, BRD4, E5, E5b, Apc2, RBM39, LGALS9, BKRF1, USP15, RIN3, DNAJC15, DNAJC16, DNAJC1, DNAJC25, DNAJC2, REPIN1, RPL7L1, DDX58, CD274, ISG15, PARK2, UFL1, DDRGK1, TRIM37, FZR1, WDR5, PAGE4, NUDCD2, NAA40, GZF1, WDR36, CDK12, ZFP62, TAF1C, TAF1A, MRPL9, MRPL11, MRPL1, ZFC3H1, PPAN-P2RY11, NGDN, YBX1, MRPS18C, MRPL24, TAF1D, CHD3, LENG8, ZNF770, MRPL51, BRIX1, MRPS30, ZNF771, MRPL18, DDX27, SREK1, ILF3, RPL26, MRPS26, TAF1B, CCDC140, NKTR, RBM28, SDAD1, RBAK, MRPL21, RRP1B, MRPL15, ZNF574, KMT2A, RPS15, NVL, TRIM41, KRR1, DDX24, NOL8, SRSF6, CCDC106, RPL36AL, MRPL13, ZC3H10, DDX54, GADD45GIP1, MRPL30, ZCCHC17, RBMX2, BMS1, ZNF777, CEBPZ, RRP8, RPF1, SPATS2L, STAU2, EME1, MRPS25, NAT10, MRPL32, PRPF4B, POP1, SRRM1, UTP23, VPRBP, ZCCHC6, MINA, DDX56, LYAR, PDCD11, ZC3H4, DDX51, PRKRA, DDX55, IMP4, NLE1, REXO4, ZNF629, ZCRB1, URB1, YTHDC2, SRPK1, SRPK2, SRP68, AURKAIP1, MRPL45, C7orf50, SRSF5, DDX18, EBNA1BP2, AATF, MPHOSPH10, ZNF92, ZNF107, PRDM15, ZNF184, URB2, RPS27A, NOC3L, TRMT1L, ZNF48, BBX, MALSU1, DGCR8, TTF1, RSBN1L, ZNF431, NOC2L, CDK13, SRPK3, SPTY2D1, RPP40, ADARB1, DDX31, RPL26L1, ZBTB11, RBM19, DNTTIP2, ZNF791, MRPL19, MRPL2, MRPL55, DHX8, RSBN1, GTPBP10, WDR89, MRPL17, HIST1H2AG, RSL1D1, MRPL16, CENPC, SURF6, MRPL47, KNOP1, BUD13, FTSJ3, HP1BP3, DDX21, PATZ1, ZC3HAV1, H1FOO, MYBBP1A, MRPL40, MRPL28, TARBP2, PWP2, GLYR1, HERC5, MAK16, DDX10, DICER1, MRPL44, DHX30, CCDC137, ABT1, BOP1, PAK1IP1, RPF2, MRPS18A, MRPL52, GLTSCR2, PRPF40A, MRPL57, ZNF22, DDA1, MRPL20, TRIM56, MRPL48, MRPL27, KRI1, FAM111A, EPB41L5, ZNF668, H2AFY, GTPBP4, RPLP1, MRPS5, HIST1H1E, ZNF768, NPM3, MRPL37, PAPD5, KBTBD6, RSL24D1, PRKRIR, WDR74, XRN1, PURA, NKRF, MRPS14, DKC1, NSA2, NOL12, ZNF512, DDX50, NOL10, GNL2, HIST2H2AB, MRPL3, BTF3, FBXW7, Fip1l1, nsp1, RCHY1, TAX1BP1, N, KLF12, LHX2, SOX2, RB1CC1, KLF16, TAL1,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
RPL13A	chr19	49993482	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL13A	chr19	49994033	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL13A	chr19	49994070	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
RPL13A	chr19	49994677	C	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL13A	chr19	49994678	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL13A	chr19	49995000	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPL13A	ESCA	chr19	49994080	49994080	C	T	Missense_Mutation	p.R101C	6
RPL13A	BRCA	chr19	49993509	49993509	C	G	Missense_Mutation	p.R37G	3
RPL13A	BRCA	chr19	49995067	49995067	G	C	Missense_Mutation	p.V203L	3
RPL13A	SKCM	chr19	49993505	49993505	C	T	Silent	p.V35V	3
RPL13A	STAD	chr19	49994304	49994304	G	A	Missense_Mutation	p.R117Q	3
RPL13A	ESCA	chr19	49994080	49994080	C	T	Missense_Mutation		3
RPL13A	ACC	chr19	49994074	49994074	C	G	Missense_Mutation	p.L99V	3
RPL13A	SKCM	chr19	49994111	49994111	C	T	Missense_Mutation	p.P111L	2
RPL13A	UCEC	chr19	49993501	49993501	T	C	Missense_Mutation	p.V34A	2
RPL13A	HNSC	chr19	49993179	49993179	G	A	Splice_Site	p.G30_splice	2
RPL13A	UCEC	chr19	49993541	49993541	C	T	Silent	p.F47	2
RPL13A	LUAD	chr19	49993753	49993753	G	T	Missense_Mutation	p.R59L	2
RPL13A	SKCM	chr19	49994103	49994103	C	T	Silent	p.I108I	2
RPL13A	UCEC	chr19	49994115	49994115	C	T	Silent	p.Y112	2
RPL13A	CESC	chr19	49993803	49993803	C	T	Missense_Mutation	p.P76S	2
RPL13A	UCEC	chr19	49994339	49994339	C	T	Silent	p.L129	2
RPL13A	CESC	chr19	49993523	49993523	C	G	Missense_Mutation	p.I41M	2
RPL13A	STAD	chr19	49993780	49993780	G	A	Missense_Mutation	p.R68Q	2
RPL13A	KIRP	chr19	49993751	49993751	C	A	Silent		2
RPL13A	SKCM	chr19	49993749	49993749	C	T	Missense_Mutation	p.L58F	2
RPL13A	SKCM	chr19	49995048	49995048	C	T	Silent	p.L196L	2
RPL13A	LIHC	chr19	49990895	49990895	G	-	Frame_Shift_Del	p.E3fs	2
RPL13A	SKCM	chr19	49993751	49993751	C	T	Silent	p.L58L	2
RPL13A	BRCA	chr19	49993772	49993772	C	A	Missense_Mutation	p.N65K	2
RPL13A	SKCM	chr19	49993752	49993752	C	T	Missense_Mutation	p.R59C	2
RPL13A	UCEC	chr19	49993146	49993146	C	T	Silent	p.L19	2
RPL13A	HNSC	chr19	49993179	49993179	G	A	Missense_Mutation		1
RPL13A	LUAD	chr19	49993733	49993733	G	A	Splice_Site	p.L52_splice	1
RPL13A	CESC	chr19	49993523	49993523	C	G	Missense_Mutation		1
RPL13A	HNSC	chr19	49994709	49994709	G	A	Missense_Mutation	p.E144K	1
RPL13A	LUAD	chr19	49993733	49993733	G	A	Silent	p.L52L	1
RPL13A	SKCM	chr19	49993748	49993748	C	T	Silent	p.F57F	1
RPL13A	HNSC	chr19	49993179	49993179	G	A	Missense_Mutation	p.G30S	1
RPL13A	SARC	chr19	49993152	49993152	G	T	Missense_Mutation		1
RPL13A	SARC	chr19	49993810	49993810	G	A	Missense_Mutation		1
RPL13A	COAD	chr19	49994985	49994985	G	A	Splice_Site	.	1
RPL13A	LGG	chr19	49993743	49993743	G	A	Missense_Mutation	p.A56T	1
RPL13A	SARC	chr19	49993810	49993810	G	A	Missense_Mutation	p.R78H	1
RPL13A	STAD	chr19	49993126	49993126	G	A	Missense_Mutation	p.R12Q	1
RPL13A	LGG	chr19	49993743	49993743	G	A	Missense_Mutation		1
RPL13A	STAD	chr19	49993758	49993758	C	T	Missense_Mutation	p.R61W	1
RPL13A	LIHC	chr19	49994320	49994320	T	C	Silent	p.A122A	1
RPL13A	ESCA	chr19	49993742	49993742	G	T	Silent	p.L55L	1
RPL13A	THYM	chr19	49993167	49993167	C	A	Missense_Mutation	p.Q26K	1
RPL13A	GBM	chr19	49994303	49994303	C	T	Missense_Mutation	p.R117W	1
RPL13A	UCEC	chr19	49993146	49993146	C	T	Silent	p.L19L	1
RPL13A	LIHC	chr19	49994110	49994110	C	-	Frame_Shift_Del	p.P111fs	1
RPL13A	GBM	chr19	49994303	49994303	C	T	Missense_Mutation		1
RPL13A	LIHC	chr19	49993801	49993801	C	-	Frame_Shift_Del	p.A75fs	1

Copy number variation (CNV) of RPL13A
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RPL13A
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
102199	BRCA	TCGA-A2-A04P-01A	DUS1L	chr17	80016657	-	RPL13A	chr19	49994297	+
102199	BLCA	TCGA-GC-A3RD-01A	FCGRT	chr19	50017743	+	RPL13A	chr19	49994036	+
102199	STAD	TCGA-BR-A4J9-01A	GLRB	chr4	158091782	+	RPL13A	chr19	49994295	+
102199	READ	TCGA-AG-3728	KIAA1107	chr1	92633440	+	RPL13A	chr19	49995374	+
102199	PRAD	TCGA-EJ-A65D	KLK2	chr19	51378136	+	RPL13A	chr19	49994682	+
102199	N/A	AA530966	LINC01033	chr5	53702612	-	RPL13A	chr19	49995096	-
102199	LAML	TCGA-AB-2986_700GJAAXX_1	MALAT1	chr11	65267237	+	RPL13A	chr19	49994993	+
102199	N/A	AX340402	MFN2	chr1	12071755	-	RPL13A	chr19	49995397	+
102199	N/A	AA535836	PLCB1	chr20	8714780	-	RPL13A	chr19	49995098	-
102199	ESCA	TCGA-L5-A88V	PRRG2	chr19	50091889	+	RPL13A	chr19	49994985	+
102199	ESCA	TCGA-L5-A88V	PRRG2	chr19	50091889	+	RPL13A	chr19	49994986	+
102199	STAD	TCGA-IN-7808-01A	RFTN1	chr3	16535232	-	RPL13A	chr19	49993489	+
101271	N/A	BM677070	RPL13A	chr19	49995427	-	ACTG1	chr17	79478723	+
82046	N/A	CF124871	RPL13A	chr19	49995565	+	ARID2	chr12	46270339	+
75906	N/A	BM723492	RPL13A	chr19	49993526	+	ARL6IP5	chr3	69153989	+
75906	N/A	EC540000	RPL13A	chr19	49994038	-	ATP5A1	chr18	43667405	+
75906	COAD	TCGA-AA-3549-01A	RPL13A	chr19	49993176	+	CERS5	chr12	50561199	-
75906	READ	TCGA-AG-3894	RPL13A	chr19	49993177	+	CERS5	chr12	50561198	-
98964	N/A	AA522752	RPL13A	chr19	49995565	+	FAM65B	chr6	24811907	-
75906	N/A	BU683473	RPL13A	chr19	49995512	-	FZD7	chr2	202902537	+
102613	N/A	BP333446	RPL13A	chr19	49995386	+	KAZN	chr1	15306034	+
75906	N/A	X06537	RPL13A	chr19	49995147	-	LCAT	chr16	67977957	-
96740	STAD	TCGA-BR-8682-01A	RPL13A	chr19	49995049	+	MALAT1	chr11	65271238	+
98609	N/A	AA888577	RPL13A	chr19	49995563	+	MFHAS1	chr8	8643266	-
101134	N/A	BG505035	RPL13A	chr19	49994778	+	RPL3	chr22	39709232	-
75906	N/A	BI493355	RPL13A	chr19	49995098	+	SCAI	chr9	127877645	+
75906	GBM	TCGA-32-4213-01A	RPL13A	chr19	49993963	+	SNORD33	chr19	49993876	+
102199	ESCA	TCGA-LN-A9FP	RPS17L	chr15	83208731	-	RPL13A	chr19	49994035	+
102199	N/A	AF176781	SMC1A	chrX	53439951	-	RPL13A	chr19	49995002	+
102199	N/A	AA552588	TTLL5	chr14	76143622	+	RPL13A	chr19	49995565	-
102200	PAAD	TCGA-US-A776-01A	ZNF493	chr19	21580069	+	RPL13A	chr19	49993107	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRC	RPL13A	0.010980255201828	0.31
SARC	RPL13A	0.0298453358447102	0.81

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LGG	RPL13A	0.0255419245395422	0.79
BRCA	RPL13A	0.0022505891024378	0.074
PAAD	RPL13A	0.0244849510696273	0.78
THYM	RPL13A	0.0410996026636243	1

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0152013	Adenocarcinoma of lung (disorder)	1	CTD_human