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Translation Factor: EIF2S3B (NCBI Gene ID:255308) |
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 Gene Summary |
| Gene Information | Gene Name: EIF2S3B | Gene ID: 255308 | Gene Symbol | EIF2S3B | Gene ID | 255308 |
| Gene Name | eukaryotic translation initiation factor 2 subunit gamma B | |
| Synonyms | EIF2S3L|eIF-2gA|eIF2gA | |
| Cytomap | 12p13.2 | |
| Type of Gene | protein-coding | |
| Description | eukaryotic translation initiation factor 2 subunit 3BeIF-2-gamma2eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDaputative eukaryotic translation initiation factor 2 subunit 3-like protein | |
| Modification date | 20200313 | |
| UniProtAcc | Q2VIR3 | |
| Child GO biological process term(s) under GO:0006412 |
| GO ID | GO term |
| GO:0006417 | Regulation of translation |
| GO:0008135 | Translation factor activity, RNA binding |
| GO:0045727 | Positive regulation of translation |
| GO:0002181 | Cytoplasmic translation |
| GO:0006413 | Translational initiation |
| GO:0006412 | Translation |
| Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Inferred gene age of translation factor. |
| Gene | Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25 |
| EIF2S3B | >1119.25 |
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| We searched PubMed using 'EIF2S3B[title] AND translation [title] AND human.' |
| Gene | Title | PMID |
| EIF2S3B | . | . |
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| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. For more annotations, please visit our ExonSkipDB. |
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| Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ENST | Exon skip start (DNA) | Exon Skip end (DNA) | ORF |
| Exon skipping position in the amino acid sequence. |
| ENST | Exon skip start (DNA) | Exon Skip end (DNA) | Len(transcript seq) | Exon skip start (mRNA) | Exon Skip end (mRNA) | Len(amino acid seq) | Exon skip start (AA) | Exon Skip end (AA) |
| Potentially (partially) lost protein functional features of UniProt. |
| UniProtAcc | Exon skip start (AA) | Exon Skip end (AA) | Function feature start (AA) | Function feature end (AA) | Functional feature type | Functional feature desc. |
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| Gene expression level across TCGA pancancer |
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| Gene expression level across GTEx pantissue |
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| Expression level of gene isoforms across TCGA pancancer |
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| Expression level of gene isoforms across GTEx pantissue |
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| Cancer(tissue) type-specific expression level of Translation factor using z-score distriution |
| Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples) |
| Cancer type | Translation factor | FC | adj.pval |
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| Translation factor expression regulation through miRNA binding |
| Cancer type | Gene | miRNA | TargetScan binding score (Context++ score percentile) | Coefficient | Pvalue |
| Translation factor expression regulation through methylation in the promoter of Translation factor |
| Cancer type | Gene | methyl group b | methyl group a | DEG pval | avg methyl in b | avg methyl in a | avg exp in b | avg exp in a |
| Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation) |
| Cancer type | Gene | methyl group b | methyl group a | DEG pval | avg methyl in b | avg methyl in a | avg exp in b | avg exp in a |
| Translation factor expression regulation through copy number variation of Translation factor |
| Cancer type | Gene | Coefficient | Pvalue |
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| Strongly correlated genes belong to cellular important gene groups with EIF2S3B (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green) |
| Cancer type | Gene group | Translation factor | Correlated gene | Coefficient | Pvalue |
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| Protein 3D structure Visit iCn3D. |
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| Protein-protein interaction networks * Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P)) |
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| Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P)) |
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 * Edge colors based on TCGA cancer types. |
| * Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P)) |
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| Cancer type | Translation factor | Interacting protein coding gene | FC | adj.pval |
| LIHC | EIF2S3B | EIF2B5 | -2.17335102876885 | 0.000112780019881286 |
| KICH | EIF2S3B | EIF2B3 | 2.17795043401278 | 0.000216901302337646 |
| PRAD | EIF2S3B | EIF2A | -1.38148128794382 | 0.000229812408986035 |
| PRAD | EIF2S3B | EIF3A | 1.13680328391952 | 0.000363360004697762 |
| THCA | EIF2S3B | EIF2B3 | -2.27193247701228 | 0.000372452864704637 |
| COAD | EIF2S3B | RPS3 | 1.48730375143014 | 0.000411599874496461 |
| STAD | EIF2S3B | EPRS | -1.48171581324647 | 0.000789262883452143 |
| KICH | EIF2S3B | EIF2S2 | -1.06278646532411 | 0.00308787822723389 |
| HNSC | EIF2S3B | EIF2B3 | -1.66956934127194 | 0.00459462782941955 |
| BLCA | EIF2S3B | EIF3A | -4.45104058307747 | 0.00532913208007812 |
| LUAD | EIF2S3B | EIF2A | -2.46315879527016 | 0.00598625106474388 |
| COAD | EIF2S3B | EIF2B3 | -1.60183733464354 | 0.00938254594802858 |
| COAD | EIF2S3B | EIF2B5 | -3.82949281161428 | 0.011966735124588 |
| LIHC | EIF2S3B | EIF2A | -2.84732374178848 | 0.0257535927654766 |
| CHOL | EIF2S3B | EIF2B2 | -1.61211785827489 | 0.02734375 |
| HNSC | EIF2S3B | RPS3 | -4.73505819095135 | 0.0273726439852453 |
| LUAD | EIF2S3B | EIF3B | -5.80435587546762 | 1.0542655358657e-09 |
| BRCA | EIF2S3B | EIF2S2 | -2.57303037687825 | 1.70212120584918e-09 |
| LIHC | EIF2S3B | EPRS | -7.10731017811505 | 2.28054594243154e-08 |
| KIRC | EIF2S3B | EIF3B | -1.56313263784517 | 2.35252849767166e-12 |
| STAD | EIF2S3B | EIF2S2 | -2.13186277769467 | 3.17529775202275e-05 |
| STAD | EIF2S3B | EIF3B | -4.7724660972007 | 3.25962901115418e-08 |
| BRCA | EIF2S3B | EIF2A | -1.00246114087146 | 3.54290594354354e-05 |
| LIHC | EIF2S3B | EIF2B2 | -1.75683032348821 | 4.08414278982391e-05 |
| LUAD | EIF2S3B | EIF2B2 | -3.96081365689084 | 4.19177862905507e-09 |
| HNSC | EIF2S3B | EIF3B | 2.6202554263604 | 4.48234413852334e-06 |
| KIRP | EIF2S3B | EIF3B | -2.7592297042974 | 4.6566128730774e-09 |
| BRCA | EIF2S3B | EIF2B3 | -1.42398409637427 | 6.27134207487183e-10 |
| BRCA | EIF2S3B | EIF3A | -1.218215573148 | 7.39403582934137e-06 |
| KIRC | EIF2S3B | RPS3 | -1.29560847926387 | 9.05905681935088e-10 |
| PRAD | EIF2S3B | EPRS | -1.76339127457265 | 9.52775218277559e-05 |
| Protein-protein interactors with this translation factor (BIOGRID-3.4.160) |
| PPI interactors with EIF2S3B |
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| Clinically associated variants from ClinVar. |
| Gene | Chr | Position | RefSeq | VarSeq | RefSeeq | VarType | Pathogenic | Disease | VarInfo |
| nsSNVs with sample frequency (size of circle) from TCGA 33 cancers. |
| SNVs and Indels |
| Gene | Cancer type | Chromosome | Start | End | RefSeeq | MutSeq | Mutation type | AAchange | # samples |
| Copy number variation (CNV) of EIF2S3B * Click on the image to open the original image in a new window. |
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| Fusion gene breakpoints (product of the structural variants (SVs)) across EIF2S3B * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion genes with this translation factor from FusionGDB2.0. |
| FusionGDB2 ID | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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| Kaplan-Meier plots with logrank tests of overall survival (OS) |
| Cancer type | Translation factor | Coefficent | Hazard ratio | Wald test pval | Likelihool ratio pval | Logrank test pval | # samples |
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| Differential gene expression between female and male. (Wilcoxon test, pval<0.05) |
| Cancer type | Translation factor | pval | adj.p |
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| Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05) |
| Cancer type | Translation factor | pval | adj.p |
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| Drugs targeting genes involved in this translation factor. (DrugBank Version 5.1.8 2021-05-08) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| Diseases associated with this translation factor. (DisGeNet 4.0) |
| Disease ID | Disease Name | # PubMeds | Disease source |
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