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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: ZNF385A (NCBI Gene ID:25946)

Gene Summary

Gene Summary

Gene Information	Gene Name: ZNF385A
	Gene ID: 25946
	Gene Symbol	ZNF385A
	Gene ID	25946
	Gene Name	zinc finger protein 385A
	Synonyms	HZF\|RZF\|ZFP385\|ZNF385
	Cytomap	12q13.13
	Type of Gene	protein-coding
	Description	zinc finger protein 385Ahematopoietic zinc finger proteinretinal zinc finger proteinzinc finger protein 385
	Modification date	20200313
	UniProtAcc	Q96PM9

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene

Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25

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Translation Studies in PubMed

We searched PubMed using 'ZNF385A[title] AND translation [title] AND human.'

Gene	Title	PMID
ZNF385A	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000394313	54764409	54764505	In-frame
ENST00000546970	54764409	54764505	In-frame
ENST00000551109	54764409	54764505	In-frame
ENST00000394313	54765256	54765499	In-frame
ENST00000546970	54765256	54765499	In-frame
ENST00000551109	54765256	54765499	In-frame
ENST00000394313	54767756	54767919	Frame-shift
ENST00000546970	54767756	54767919	Frame-shift
ENST00000551109	54767756	54767919	Frame-shift
ENST00000394313	54769627	54769738	In-frame
ENST00000546970	54769627	54769738	In-frame
ENST00000551109	54769627	54769738	In-frame
ENST00000546970	54778642	54778786	3UTR-3UTR

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000551109	54764409	54764505	2386	920	1015	386	258	290
ENST00000394313	54764409	54764505	2447	984	1079	386	258	290
ENST00000546970	54764409	54764505	2511	1065	1160	386	258	290
ENST00000551109	54765256	54765499	2386	507	749	386	120	201
ENST00000394313	54765256	54765499	2447	571	813	386	120	201
ENST00000546970	54765256	54765499	2511	652	894	386	120	201
ENST00000551109	54769627	54769738	2386	233	343	386	29	66
ENST00000394313	54769627	54769738	2447	297	407	386	29	66
ENST00000546970	54769627	54769738	2511	378	488	386	29	66

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
Q96PM9	120	201	1	386	Chain	ID=PRO_0000047554;Note=Zinc finger protein 385A
Q96PM9	258	290	1	386	Chain	ID=PRO_0000047554;Note=Zinc finger protein 385A
Q96PM9	29	66	1	386	Chain	ID=PRO_0000047554;Note=Zinc finger protein 385A
Q96PM9	120	201	1	386	Chain	ID=PRO_0000047554;Note=Zinc finger protein 385A
Q96PM9	258	290	1	386	Chain	ID=PRO_0000047554;Note=Zinc finger protein 385A
Q96PM9	29	66	1	386	Chain	ID=PRO_0000047554;Note=Zinc finger protein 385A
Q96PM9	120	201	1	386	Chain	ID=PRO_0000047554;Note=Zinc finger protein 385A
Q96PM9	258	290	1	386	Chain	ID=PRO_0000047554;Note=Zinc finger protein 385A
Q96PM9	29	66	1	386	Chain	ID=PRO_0000047554;Note=Zinc finger protein 385A
Q96PM9	120	201	201	225	Zinc finger	Note=Matrin-type 2
Q96PM9	120	201	201	225	Zinc finger	Note=Matrin-type 2
Q96PM9	120	201	201	225	Zinc finger	Note=Matrin-type 2
Q96PM9	258	290	261	285	Zinc finger	Note=Matrin-type 3
Q96PM9	258	290	261	285	Zinc finger	Note=Matrin-type 3
Q96PM9	258	290	261	285	Zinc finger	Note=Matrin-type 3
Q96PM9	120	201	145	351	Region	Note=Necessary for binding to ITPR1%2C CEBPA and p53/TP53 mRNAs;Ontology_term=ECO:0000250;evidence=ECO:0000250
Q96PM9	258	290	145	351	Region	Note=Necessary for binding to ITPR1%2C CEBPA and p53/TP53 mRNAs;Ontology_term=ECO:0000250;evidence=ECO:0000250
Q96PM9	120	201	145	351	Region	Note=Necessary for binding to ITPR1%2C CEBPA and p53/TP53 mRNAs;Ontology_term=ECO:0000250;evidence=ECO:0000250
Q96PM9	258	290	145	351	Region	Note=Necessary for binding to ITPR1%2C CEBPA and p53/TP53 mRNAs;Ontology_term=ECO:0000250;evidence=ECO:0000250
Q96PM9	120	201	145	351	Region	Note=Necessary for binding to ITPR1%2C CEBPA and p53/TP53 mRNAs;Ontology_term=ECO:0000250;evidence=ECO:0000250
Q96PM9	258	290	145	351	Region	Note=Necessary for binding to ITPR1%2C CEBPA and p53/TP53 mRNAs;Ontology_term=ECO:0000250;evidence=ECO:0000250
Q96PM9	120	201	185	185	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
Q96PM9	120	201	185	185	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
Q96PM9	120	201	185	185	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
Q96PM9	120	201	141	221	Alternative sequence	ID=VSP_047449;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:14702039,ECO:0000303\|Ref.4;Dbxref=PMID:14702039
Q96PM9	120	201	141	221	Alternative sequence	ID=VSP_047449;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:14702039,ECO:0000303\|Ref.4;Dbxref=PMID:14702039
Q96PM9	120	201	141	221	Alternative sequence	ID=VSP_047449;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:14702039,ECO:0000303\|Ref.4;Dbxref=PMID:14702039

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
KICH	ZNF385A	-1.23732069845073	0.00507164001464844

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
MESO	ZNF385A	hsa-miR-125b-5p	97	-0.300316455696203	0.00736443032726624
UCEC	ZNF385A	hsa-miR-185-5p	90	0.357983193277311	0.0383058530561773

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
LUAD	ZNF385A	0.060660283	0.045686662

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with ZNF385A (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	Epifactor	ZNF385A	NAP1L1	0.820468554	5.27E-12
CHOL	IUPHAR	ZNF385A	ORAI2	0.818380759	6.61E-12
DLBC	Cell metabolism gene	ZNF385A	CDA	0.806110518	4.74E-12
DLBC	Cell metabolism gene	ZNF385A	GAA	0.806207128	4.69E-12
DLBC	Cell metabolism gene	ZNF385A	PLD3	0.821709968	8.24E-13
DLBC	Cell metabolism gene	ZNF385A	PI4K2A	0.833601729	1.93E-13
DLBC	CGC	ZNF385A	ARHGEF10L	0.803257077	6.42E-12
DLBC	IUPHAR	ZNF385A	CDA	0.806110518	4.74E-12
DLBC	IUPHAR	ZNF385A	GAA	0.806207128	4.69E-12
DLBC	IUPHAR	ZNF385A	SLC31A2	0.808118163	3.82E-12
DLBC	IUPHAR	ZNF385A	ATP6V1B2	0.830478314	2.86E-13
DLBC	IUPHAR	ZNF385A	PI4K2A	0.833601729	1.93E-13
ESCA	Cell metabolism gene	ZNF385A	GM2A	0.821996045	2.55E-49
ESCA	CGC	ZNF385A	TP63	0.855089851	3.04E-57
ESCA	IUPHAR	ZNF385A	GPR87	0.828187275	1.13E-50
ESCA	IUPHAR	ZNF385A	S1PR5	0.84494014	1.28E-54
ESCA	TF	ZNF385A	FOXE1	0.812384417	2.53E-47
ESCA	TF	ZNF385A	BNC1	0.84734026	3.20E-55
ESCA	TF	ZNF385A	SOX15	0.855017971	3.18E-57
ESCA	TF	ZNF385A	TP63	0.855089851	3.04E-57
ESCA	TSG	ZNF385A	PHLDA3	0.800058157	6.36E-45
ESCA	TSG	ZNF385A	SOX15	0.855017971	3.18E-57
ESCA	TSG	ZNF385A	TP63	0.855089851	3.04E-57
KIRP	CGC	ZNF385A	PTPN6	0.816319309	1.65E-78
KIRP	TSG	ZNF385A	PTPN6	0.816319309	1.65E-78
TGCT	IUPHAR	ZNF385A	SLC38A6	0.810537753	1.31E-37

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KICH	ZNF385A	CA8	-2.27231740537809	0.000376403331756592
PRAD	ZNF385A	ERP44	1.12699963506714	0.00074054058184854
KIRP	ZNF385A	SFN	-1.5586826403751	0.00275033386424184
CHOL	ZNF385A	CCDC86	-7.30090402016384	0.00390625
PRAD	ZNF385A	CCDC86	1.33561975489739	0.00430343371125972
LUAD	ZNF385A	CA8	-2.17843315203572	0.00557540274754635
PRAD	ZNF385A	APTX	1.13854182587478	0.0114986029310557
UCEC	ZNF385A	CA8	1.38351413540213	0.015625
UCEC	ZNF385A	TP53	2.03295038376694	0.015625
KICH	ZNF385A	CCDC86	-2.43367611183207	1.0073184967041e-05
KICH	ZNF385A	UFSP2	-2.18793451579628	1.19209289550781e-07
PRAD	ZNF385A	UFSP2	-1.52361672035078	1.36149289150376e-08
LIHC	ZNF385A	PCBP4	-4.92698773444098	1.43245297778818e-07
HNSC	ZNF385A	CCDC86	2.04651811162535	2.06497293220309e-06
HNSC	ZNF385A	CA8	2.01804434104404	2.23590586756473e-06
COAD	ZNF385A	PCBP4	-1.42064425918031	3.18586826324463e-05
THCA	ZNF385A	PCBP4	-1.98875110272785	3.42070355819392e-07
KIRP	ZNF385A	ITPR1	-9.9058450232399	4.20957803726197e-07
KIRC	ZNF385A	TP53	-1.43050981150632	4.58942580328929e-09
LIHC	ZNF385A	CCDC86	-1.520687251177	4.74734387705512e-06
KIRP	ZNF385A	CCDC86	-1.4064769691495	5.97489997744561e-06
BRCA	ZNF385A	UFSP2	-1.90790827044653	6.05109462978858e-22
THCA	ZNF385A	TP53	-1.81960143635647	6.18215597921662e-07
THCA	ZNF385A	SFN	-2.25844781279925	6.60703547982167e-09
LUSC	ZNF385A	SFN	1.31744327237347	6.73150912313732e-09
LUAD	ZNF385A	CCDC86	-2.11214025060402	6.80092398173796e-10
THCA	ZNF385A	ITPR1	-2.90829572705718	7.50861561019654e-11
LUSC	ZNF385A	PCBP4	1.32682041673836	7.61148795377e-06
KIRP	ZNF385A	UFSP2	-1.36386354690062	7.71600753068924e-06
KICH	ZNF385A	SFN	1.27792297441414	8.16583633422851e-06
LIHC	ZNF385A	SFN	-1.8398176796087	8.97466888721789e-06
LUAD	ZNF385A	ITPR1	-1.26496103413596	9.53955602455483e-07
KIRC	ZNF385A	CCDC86	-1.05188511068327	9.72008324442528e-10

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with ZNF385A

CEP57, HNRNPL, DCAF15, PLEKHA4, MIR1-1, MIR9-1, MIR9-2, MIR9-3, MIR19A, MIR19B1, MIR19B2, MIR34C, MIR155, ESR1, DDX58, OGT,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
ZNF385A	chr12	54764512	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
ZNF385A	chr12	54765486	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
ZNF385A	LUAD	chr12	54767848	54767848	G	C	Silent	p.T90T	7
ZNF385A	UCEC	chr12	54769642	54769642	G	A	Missense_Mutation	p.R82C	5
ZNF385A	BLCA	chr12	54765456	54765456	C	T	Silent	p.E135E	3
ZNF385A	CHOL	chr12	54778336	54778336	C	T	Missense_Mutation		3
ZNF385A	KIRP	chr12	54764720	54764720	T	C	Silent	p.Q275Q	3
ZNF385A	CHOL	chr12	54778336	54778336	C	T	Missense_Mutation	p.R8Q	3
ZNF385A	CESC	chr12	54767826	54767826	G	T	Silent		3
ZNF385A	ACC	chr12	54778302	54778302	C	T	Silent	p.P19P	3
ZNF385A	ESCA	chr12	54767829	54767829	C	T	Missense_Mutation	p.V117I	2
ZNF385A	UCEC	chr12	54764494	54764494	G	A	Silent	p.S282	2
ZNF385A	CESC	chr12	54764831	54764831	G	C	Missense_Mutation	p.I238M	2
ZNF385A	ESCA	chr12	54767829	54767829	C	T	Missense_Mutation		2
ZNF385A	SARC	chr12	54764842	54764842	G	T	Missense_Mutation		2
ZNF385A	BLCA	chr12	54765302	54765302	T	C	Missense_Mutation	p.K187E	2
ZNF385A	STAD	chr12	54765373	54765373	G	A	Missense_Mutation	p.P163L	2
ZNF385A	UCEC	chr12	54765316	54765316	T	C	Missense_Mutation	p.Y202C	2
ZNF385A	BRCA	chr12	54778269	54778269	G	A	Silent	p.I30	2
ZNF385A	UCEC	chr12	54778302	54778302	C	T	Silent	p.P19	2
ZNF385A	LIHC	chr12	54764799	54764799	G	-	Frame_Shift_Del	p.P229fs	2
ZNF385A	SKCM	chr12	54767881	54767881	G	A	Silent	p.A79A	2
ZNF385A	STAD	chr12	54765331	54765331	G	A	Missense_Mutation		2
ZNF385A	SKCM	chr12	54764795	54764795	C	T	Silent	p.G230G	2
ZNF385A	CESC	chr12	54764853	54764853	G	A	Missense_Mutation		2
ZNF385A	STAD	chr12	54765373	54765373	G	A	Missense_Mutation	p.P183L	2
ZNF385A	CESC	chr12	54764831	54764831	G	C	Missense_Mutation		2
ZNF385A	LIHC	chr12	54769700	54769700	A	-	Frame_Shift_Del	p.F42fs	2
ZNF385A	SKCM	chr12	54764812	54764812	C	T	Missense_Mutation	p.G225R	2
ZNF385A	ESCA	chr12	54764155	54764155	C	A	Missense_Mutation	p.R349L	2
ZNF385A	SARC	chr12	54778274	54778274	G	T	Missense_Mutation		1
ZNF385A	SKCM	chr12	54765286	54765286	G	A	Missense_Mutation	p.S192F	1
ZNF385A	HNSC	chr12	54764735	54764735	G	A	Silent	p.V250V	1
ZNF385A	STAD	chr12	54765331	54765331	G	A	Missense_Mutation	p.A177V	1
ZNF385A	LIHC	chr12	54764851	54764851	G	-	Frame_Shift_Del	p.R212fs	1
ZNF385A	SKCM	chr12	54764811	54764811	C	T	Missense_Mutation	p.G225E	1
ZNF385A	HNSC	chr12	54767763	54767763	G	A	Missense_Mutation	p.R119C	1
ZNF385A	CESC	chr12	54764853	54764853	G	A	Missense_Mutation	p.A231V	1
ZNF385A	LIHC	chr12	54767798	54767798	C	-	Frame_Shift_Del	p.G107fs	1
ZNF385A	ESCA	chr12	54764422	54764422	G	A	Silent		1
ZNF385A	SARC	chr12	54763922	54763922	G	-	RNA	NULL	1
ZNF385A	SKCM	chr12	54767880	54767880	G	A	Nonsense_Mutation	p.R80*	1
ZNF385A	KIRC	chr12	54764794	54764794	C	-	Frame_Shift_Del	p.E251fs	1
ZNF385A	STAD	chr12	54764440	54764440	G	C	Missense_Mutation	p.H280Q	1
ZNF385A	ESCA	chr12	54764155	54764155	C	A	Missense_Mutation		1
ZNF385A	SKCM	chr12	54764789	54764789	T	-	Frame_Shift_Del	p.P232fs	1
ZNF385A	CESC	chr12	54767812	54767812	G	A	Silent		1
ZNF385A	STAD	chr12	54764723	54764723	G	C	Silent	p.V254V	1
ZNF385A	LIHC	chr12	54769695	54769695	C	-	Frame_Shift_Del	p.G44fs	1
ZNF385A	ESCA	chr12	54764422	54764422	G	A	Silent	p.A306A	1
ZNF385A	SKCM	chr12	54764789	54764789	T	-	Frame_Shift_Del	p.E253fs	1
ZNF385A	CESC	chr12	54778212	54778212	G	A	Silent		1
ZNF385A	KIRP	chr12	54764720	54764720	T	C	Silent	p.Q255Q	1
ZNF385A	STAD	chr12	54764782	54764782	G	A	Missense_Mutation	p.P235S	1
ZNF385A	COAD	chr12	54765265	54765265	T	C	Missense_Mutation	p.H199R	1
ZNF385A	LIHC	chr12	54764776	54764776	G	-	Frame_Shift_Del	p.Q237fs	1
ZNF385A	ESCA	chr12	54767819	54767819	G	T	Missense_Mutation	p.P120H	1
ZNF385A	STAD	chr12	54765331	54765331	G	A	Missense_Mutation	p.A197V	1
ZNF385A	KIRP	chr12	54764720	54764720	T	C	Silent		1
ZNF385A	STAD	chr12	54764831	54764831	G	C	Missense_Mutation	p.I218M	1
ZNF385A	COAD	chr12	54767812	54767812	G	A	Silent	p.D102D	1
ZNF385A	ESCA	chr12	54767829	54767829	C	T	Missense_Mutation	p.V97I	1
ZNF385A	LGG	chr12	54765377	54765377	C	T	Missense_Mutation	p.A162T	1
ZNF385A	STAD	chr12	54765308	54765308	G	C	Missense_Mutation	p.L185V	1
ZNF385A	SKCM	chr12	54769709	54769709	G	A	Silent	p.S39S	1
ZNF385A	COAD	chr12	54769666	54769666	T	C	Missense_Mutation	p.I54V	1
ZNF385A	LUSC	chr12	54767862	54767862	C	G	Missense_Mutation	p.E106Q	1
ZNF385A	ESCA	chr12	54764422	54764422	G	A	Silent	p.A286A	1
ZNF385A	STAD	chr12	54765308	54765308	G	C	Missense_Mutation	p.L205V	1
ZNF385A	LGG	chr12	54765377	54765377	C	T	Missense_Mutation		1
ZNF385A	THYM	chr12	54763757	54763757	G	-	RNA	NULL	1
ZNF385A	SKCM	chr12	54764813	54764813	C	T	Silent	p.L224L	1
ZNF385A	COAD	chr12	54769670	54769670	G	A	Silent	p.P52P	1
ZNF385A	OV	chr12	54765326	54765326	G	A	Missense_Mutation	p.R199W	1
ZNF385A	ESCA	chr12	54764155	54764155	C	A	Missense_Mutation	p.R329L	1
ZNF385A	STAD	chr12	54764782	54764782	G	A	Missense_Mutation	p.P255S	1
ZNF385A	CESC	chr12	54764431	54764431	A	T	Silent	p.S283S	1
ZNF385A	UCEC	chr12	54769670	54769670	G	A	Silent	p.P72P	1
ZNF385A	PRAD	chr12	54764451	54764451	G	A	Silent	p.L277L	1
ZNF385A	BLCA	chr12	54765456	54765456	C	T	Silent		1
ZNF385A	HNSC	chr12	54767763	54767763	G	A	Missense_Mutation		1
ZNF385A	STAD	chr12	54764440	54764440	G	C	Missense_Mutation	p.H300Q	1
ZNF385A	CESC	chr12	54764453	54764453	A	T	Missense_Mutation	p.L276Q	1
ZNF385A	LIHC	chr12	54764418	54764418	C	-	Frame_Shift_Del	p.E288fs	1
ZNF385A	SKCM	chr12	54765485	54765485	C	T	Missense_Mutation	p.G126R	1
ZNF385A	ESCA	chr12	54764422	54764422	G	A	Silent	p.A306	1
ZNF385A	READ	chr12	54769632	54769632	G	T	Missense_Mutation	p.S85Y	1
ZNF385A	BLCA	chr12	54765302	54765302	T	C	Missense_Mutation		1
ZNF385A	HNSC	chr12	54764735	54764735	G	A	Silent		1
ZNF385A	STAD	chr12	54764723	54764723	G	C	Silent	p.V274V	1
ZNF385A	UCEC	chr12	54764494	54764494	G	A	Silent	p.S282S	1
ZNF385A	CESC	chr12	54764853	54764853	G	A	Missense_Mutation	p.A211V	1
ZNF385A	LIHC	chr12	54764426	54764426	C	-	Frame_Shift_Del	p.G285fs	1

Copy number variation (CNV) of ZNF385A
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across ZNF385A
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
73581	N/A	AW291910	MRE11A	chr11	94151783	+	ZNF385A	chr12	54763048	-
73581	BLCA	TCGA-XF-AAMY	R3HDM2	chr12	57704046	-	ZNF385A	chr12	54769738	-
73581	BLCA	TCGA-XF-AAMY-01A	R3HDM2	chr12	57704047	-	ZNF385A	chr12	54769738	-
73581	N/A	DA465008	REV1	chr2	100093851	-	ZNF385A	chr12	54778479	-
101957	LIHC	TCGA-DD-A1EF-01A	ZNF385A	chr12	54767757	-	CBX5	chr12	54651476	-
101957	SARC	TCGA-DX-A23R-01A	ZNF385A	chr12	54778212	-	NAV3	chr12	78552983	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
SKCM	ZNF385A	0.0171933259798579	0.48
SARC	ZNF385A	0.0365439613206284	0.99

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
STAD	ZNF385A	0.00822964499339568	0.25
THCA	ZNF385A	0.0372785575385782	0.97
KICH	ZNF385A	0.0148404695515452	0.42
BRCA	ZNF385A	0.00103006731036978	0.032
ESCA	ZNF385A	4.41719230010139e-05	0.0015
THYM	ZNF385A	0.000227918977250934	0.0073
SARC	ZNF385A	0.0119861543582251	0.35
HNSC	ZNF385A	0.0298291358441772	0.81

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source