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Center for Computational Systems Medicine
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Gene Summary

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Translation studies in PubMed

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Exon Skipping Events

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Expression

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Expression Regulation

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Associated Genes

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Protein 3D Structure

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Protein-Protein Interaction

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Mutations

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Prognostic Analysis

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Gender Association

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Age Association

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Related Drugs

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Related Diseases

Translation Factor: MTG2 (NCBI Gene ID:26164)


Gene Summary

check button Gene Summary
Gene InformationGene Name: MTG2
Gene ID: 26164
Gene Symbol

MTG2

Gene ID

26164

Gene Namemitochondrial ribosome associated GTPase 2
SynonymsGTPBP5|ObgH1|dJ1005F21.2
Cytomap

20q13.33

Type of Geneprotein-coding
Descriptionmitochondrial ribosome-associated GTPase 2GTP binding protein 5 (putative)GTP-binding protein 5protein obg homolog 1
Modification date20200313
UniProtAcc

Q9H4K7


check button Child GO biological process term(s) under GO:0006412
GO IDGO term
GO:0006417Regulation of translation
GO:0032543Mitochondrial translation
GO:0005840Ribosome
GO:0006412Translation


check button Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Inferred gene age of translation factor.
GeneInferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
MTG2>1119.25


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Translation Studies in PubMed

check button We searched PubMed using 'MTG2[title] AND translation [title] AND human.'
GeneTitlePMID
MTG2..


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Exon Skipping Events

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.
all structure

check button Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ENSTExon skip start (DNA)Exon Skip end (DNA)ORF
ENST0000037082360768471607686805CDS-5UTR
ENST000003708236077290760773023Frame-shift
ENST000003708236077368960773908In-frame
ENST000003708236077417460774313Frame-shift

check button Exon skipping position in the amino acid sequence.
ENSTExon skip start (DNA)Exon Skip end (DNA)Len(transcript seq)Exon skip start (mRNA)Exon Skip end (mRNA)Len(amino acid seq)Exon skip start (AA)Exon Skip end (AA)
ENST0000037082360773689607739082946487705406156229

check button Potentially (partially) lost protein functional features of UniProt.
UniProtAccExon skip start (AA)Exon Skip end (AA)Function feature start (AA)Function feature end (AA)Functional feature typeFunctional feature desc.
Q9H4K71562291406ChainID=PRO_0000205429;Note=Mitochondrial ribosome-associated GTPase 2
Q9H4K7156229225390DomainNote=OBG-type G
Q9H4K715622915406RegionNote=Localized in the mitochondria
Q9H4K715622930406RegionNote=Not localized in the mitochondria
Q9H4K71562291228Alternative sequenceID=VSP_056672;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039


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Expression


check buttonGene expression level across TCGA pancancer
all structure

check buttonGene expression level across GTEx pantissue
all structure

check buttonExpression level of gene isoforms across TCGA pancancer
all structure

check buttonExpression level of gene isoforms across GTEx pantissue
all structure

check buttonCancer(tissue) type-specific expression level of Translation factor using z-score distriution

check buttonDifferential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)
Cancer typeTranslation factorFCadj.pval


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Expression Regulation


check buttonTranslation factor expression regulation through miRNA binding
Cancer typeGenemiRNATargetScan binding score (Context++ score percentile)CoefficientPvalue


check buttonTranslation factor expression regulation through methylation in the promoter of Translation factor
Cancer typeGenemethyl group bmethyl group aDEG pvalavg methyl in bavg methyl in aavg exp in bavg exp in a

check buttonTranslation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)
Cancer typeGenemethyl group bmethyl group aDEG pvalavg methyl in bavg methyl in aavg exp in bavg exp in a

check buttonTranslation factor expression regulation through copy number variation of Translation factor
Cancer typeGeneCoefficientPvalue

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Associated Genes


check button Strongly correlated genes belong to cellular important gene groups with MTG2 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)
Cancer typeGene groupTranslation factorCorrelated geneCoefficientPvalue


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Protein structure


check button Protein 3D structure
Visit iCn3D.


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Protein-Protein Interaction


check button Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))
all structure

check buttonOverlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))
all structure
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* Edge colors based on TCGA cancer types.

check button* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))
all structure
Cancer typeTranslation factorInteracting protein coding geneFCadj.pval
STADMTG2MTIF2-1.910990173655550.000110303983092308
PRADMTG2MTIF2-2.911639452327320.000148819683073472
THCAMTG2MTIF21.019099600642390.00052377205169468
ESCAMTG2FTSJ2-1.613898390117010.001953125
COADMTG2ERAL1-5.449381497899950.00197160243988037
STADMTG2NSUN4-1.471621930956990.00256496202200651
COADMTG2NSUN4-1.807365284520280.00322914123535157
STADMTG2GUF11.782198091773190.0044123362749815
LIHCMTG2ERAL11.126771345941740.00611535631403997
PRADMTG2ICT1-1.548484449093520.00907723161841939
KICHMTG2FTSJ2-1.385354491378160.00963503122329712
BRCAMTG2GUF11.164630298105380.0111057964084058
THCAMTG2FTSJ2-1.072569531721160.0137237433303792
KIRCMTG2MTIF2-1.305755114750860.0182888755834972
STADMTG2MTG1-1.431603681806650.018431528005749
READMTG2ERAL1-2.059564591255710.03125
READMTG2NSUN4-3.483209807646720.03125
HNSCMTG2ERAL1-3.609320519498860.0374699628314374
BLCAMTG2NSUN41.357371266361450.040130615234375
LUSCMTG2MTG1-9.25332058471581.09583750788394e-07
LUADMTG2GUF1-2.123047461087551.70635806144212e-09
BRCAMTG2ERAL1-3.27528693947052.01669698147401e-14
THCAMTG2GUF12.190976534568552.3500379803691e-10
LIHCMTG2FTSJ2-1.737399667428822.45951750356437e-05
BRCAMTG2ICT1-4.174882204496642.73719348917167e-14
LUADMTG2MTIF2-5.143565887097143.996080695583e-11
KICHMTG2ERAL12.209143006209184.54187393188476e-05
KICHMTG2GUF11.923572681265274.54187393188476e-05
STADMTG2FTSJ2-1.905456580097085.12227416038514e-08
KIRCMTG2FTSJ2-1.378109092289575.70454543514536e-06
LUADMTG2ERAL1-1.93681767966555.86928774688463e-10
LUSCMTG2ICT1-3.230933760494566.60526357089358e-07
LUSCMTG2GUF1-2.10758322180767.28442422628201e-06
LUADMTG2MTG1-1.455022619533759.14904976982756e-06


check button Protein-protein interactors with this translation factor (BIOGRID-3.4.160)
PPI interactors with MTG2
MAPK6, TAB1, OXLD1, MRPL12, WDYHV1, PREP, LAMP2, C1orf85, ATP5D, BPNT1, TOMM22, CD79A, LRP1, HSPD1, CLPP, MTIF2, PMPCA, SIRT3, NPM2, KRAS, PLEKHA4, AUH, CRYZ, HINT2, AARS2, ABCB7, ACAD9, ACADM, ACAT1, ACOT1, ACOT2, AFG3L2, AK4, ALAS1, ALDH1B1, ALDH2, ALYREF, ATAD3B, ATP5B, ATP5C1, ATPIF1, ATP5I, ATP5F1, ATP5H, ATP5J, ATP5O, ATPAF1, BCS1L, C17orf80, CARS2, CDK5RAP1, CLPX, COQ5, ADCK4, COX5A, CPD, CS, DAP3, DARS2, DBT, DDX28, DHTKD1, DHX30, DLAT, DLST, DNAJA3, ECHS1, ECSIT, ELAC2, ERAL1, ETFA, ETFB, FASTKD2, FKBP8, GARS, GCDH, GFM1, GLS, GLUD1, GRPEL1, GRSF1, GTPBP10, GTPBP3, GTPBP6, GUF1, HADH, HADHA, HARS2, CECR5, HNRNPAB, HNRNPDL, HNRNPL, HSD17B10, HSPA9, HSPE1, IARS2, IDH3A, IVD, LARS2, LEMD3, LETM1, LMNB1, LONP1, LRPPRC, LUC7L, MALSU1, MDH2, ME2, METTL15, MMAB, MUT, FTSJ2, RNMTL1, MRPL1, MRPL10, MRPL11, MRPL13, MRPL14, MRPL15, MRPL16, MRPL17, MRPL2, MRPL20, MRPL21, MRPL22, MRPL23, MRPL24, MRPL27, MRPL28, MRPL3, MRPL37, MRPL38, MRPL39, MRPL4, MRPL40, MRPL41, MRPL43, MRPL44, MRPL45, MRPL46, MRPL47, MRPL48, MRPL49, MRPL50, MRPL52, MRPL54, MRPL55, ICT1, MRPL9, MRPS10, MRPS11, MRPS14, MRPS16, MRPS17, MRPS18B, MRPS2, MRPS22, MRPS23, MRPS24, MRPS25, MRPS26, MRPS27, MRPS28, MRPS30, MRPS31, MRPS33, MRPS34, MRPS35, MRPS36, MRPS5, MRPS6, MRPS7, MRPS9, MTHFD2, NDUFA12, NDUFA2, NDUFA5, NDUFA6, NDUFA7, NDUFA9, NDUFAF1, NDUFAF2, NDUFAF3, NDUFAF4, NDUFAF5, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, NFS1, NFU1, NME4, NNT, NT5DC2, NUBPL, NUDT19, OAT, OGDH, PDE12, PDHA1, PDHB, PDHX, PDK3, PDPR, PHB, PNPT1, POLDIP2, POLG, POLRMT, PPA2, PPIF, PREPL, PTCD3, PUS1, PYCR1, PYCR2, QRSL1, RAB10, RBM28, SHMT2, SLC30A9, SLIRP, STOML2, SUCLA2, TACO1, TARS2, TEFM, TIMM44, TRMT10C, TSFM, TUFM, C10orf2, USP30, VARS2, VWA8, YARS2, ATG7, MGARP, BCL2L12, UQCRFS1, ADAM11, RUFY3, SFTPA2, SCGB2A2, PFDN5, NPM1, CD14, HLA-DRA, FAHD1, TOMM40, MCCC1, ACSM5, ALPI, AMACR, PPOX, ARMC8, FAM207A, CPS1, SHC2, INPP5K, PCCB, NDUFB9, NIPSNAP3A, BCKDK, ACSF2, CBR4, PCCA, UBR1,


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Mutations


check button Clinically associated variants from ClinVar.
GeneChrPositionRefSeqVarSeqRefSeeqVarTypePathogenicDiseaseVarInfo


check button nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.
all structure


check button SNVs and Indels
GeneCancer typeChromosomeStartEndRefSeeqMutSeqMutation typeAAchange# samples
MTG2PRADchr206077300560773005CTSilentp.G150G3
MTG2KIRCchr206077384960773849CTNonsense_Mutationp.Q210*2
MTG2SARCchr206077428760774287AGMissense_Mutationp.H267R2
MTG2CESCchr206076857360768573CTMissense_Mutation2
MTG2HNSCchr206077585860775858GCMissense_Mutationp.E316Q2
MTG2LUADchr206077575060775750CTMissense_Mutationp.P280S2
MTG2LUADchr206077575160775751CTMissense_Mutationp.P280L2
MTG2PRADchr206077581360775813GAMissense_Mutationp.E301K2
MTG2HNSCchr206077603160776031GASilentp.L373L1
MTG2SKCMchr206077599260775992GASilentp.R360R1
MTG2BLCAchr206077583660775836CAMissense_Mutation1
MTG2LUADchr206077576860775768GAMissense_Mutationp.A286T1
MTG2STADchr206077576260775762CTNonsense_Mutationp.R284*1
MTG2HNSCchr206077578460775784GAMissense_Mutation1
MTG2SARCchr206077428760774287AGMissense_Mutation1
MTG2SKCMchr206076848360768483CTMissense_Mutationp.P3S1
MTG2BLCAchr206077604760776047GCMissense_Mutation1
MTG2LUADchr206077374560773745G-Frame_Shift_Delp.C175fs1
MTG2STADchr206077097460770974CTSilentp.D107D1
MTG2HNSCchr206077611460776114GCMissense_Mutation1
MTG2SARCchr206077369860773698GTSilent1
MTG2LGGchr206077578960775789GAMissense_Mutationp.G293R1
MTG2SKCMchr206076852260768522CTNonsense_Mutationp.Q16*1
MTG2BLCAchr206076859960768599CTSilentp.P41P1
MTG2PAADchr206077423560774235GAMissense_Mutation1
MTG2THCAchr206076849760768497CTSilent1
MTG2HNSCchr206077585860775858GCMissense_Mutation1
MTG2LIHCchr206077591160775911G-Frame_Shift_Delp.K333fs1
MTG2SKCMchr206077390260773902CTSilentp.A227A1
MTG2BLCAchr206077594160775941CTSilentp.V343V1
MTG2PAADchr206077296560772965GAMissense_Mutation1
MTG2THCAchr206076861560768615GAMissense_Mutation1
MTG2HNSCchr206077294760772947GTMissense_Mutation1
MTG2SARCchr206077275260772752TARNANULL1
MTG2SKCMchr206077384760773847GAMissense_Mutationp.G209E1
MTG2LUADchr206077611760776117ATMissense_Mutationp.Q402L1
MTG2BLCAchr206077604760776047GCMissense_Mutationp.E379Q1
MTG2PAADchr206076866060768660CTSilent1
MTG2HNSCchr206077425260774252GASilent1
MTG2SARCchr206077286460772864GCRNANULL1
MTG2LUADchr206077296760772967GAMissense_Mutationp.E138K1
MTG2STADchr206077609160776091GASilent1
MTG2PAADchr206077423560774235GAMissense_Mutationp.A250T1
MTG2HNSCchr206077578460775784GAMissense_Mutationp.G291D1
MTG2SKCMchr206077576660775766GCMissense_Mutationp.G285A1
MTG2LUADchr206077388760773887GASilentp.K222K1
MTG2CHOLchr206076851660768516GAMissense_Mutation1
MTG2PAADchr206076866060768660CTSilentp.L62L1
MTG2HNSCchr206077419560774195GASilentp.G236G1
MTG2SKCMchr206077389960773899CTSilentp.H226H1
MTG2LUADchr206077091860770918GTMissense_Mutationp.A89S1
MTG2CHOLchr206076851660768516GAMissense_Mutationp.V14M1
MTG2PAADchr206077296560772965GAMissense_Mutationp.G137E1
MTG2SKCMchr206077098760770987GAMissense_Mutationp.G112R1
MTG2BLCAchr206076859960768599CTSilent1
MTG2LUADchr206076850560768505GTMissense_Mutationp.R10I1
MTG2ESCAchr206077576760775767CASilentp.G2851
MTG2HNSCchr206077425260774252GASilentp.P255P1
MTG2SKCMchr206077574960775749CTSilentp.I279I1
MTG2BLCAchr206077594160775941CTSilent1
MTG2ESCAchr206077576760775767CASilent1
MTG2PRADchr206077376960773769CTMissense_Mutationp.A183V1
MTG2HNSCchr206076865060768650GASilentp.P58P1
MTG2SKCMchr206077292760772927CTSilentp.S124S1
MTG2BLCAchr206077380360773803CGMissense_Mutation1
MTG2STADchr206077609160776091GASilentp.A393A1
MTG2ESCAchr206077576760775767CASilentp.G285G1

check buttonCopy number variation (CNV) of MTG2
* Click on the image to open the original image in a new window.
all structure

check buttonFusion gene breakpoints (product of the structural variants (SVs)) across MTG2
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


check button Fusion genes with this translation factor from FusionGDB2.0.
FusionGDB2 IDDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
61808N/AAV695800CYP2C8chr1096827516+MTG2chr2060778200+
102522STADTCGA-BR-A4J5-01AMTG2chr2060776043+AGR2chr716841341-
99632N/AAV696720MTG2chr2060778624+RCOR1chr14103073771-
101394N/AAA528443MTG2chr2060774700-ZNF222chr1944537256-
61813UCECTCGA-K6-A3WQ-01AOSBPL2chr2060813653+MTG2chr2060768472+


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Prognostic Analysis


check button Kaplan-Meier plots with logrank tests of overall survival (OS)
Cancer typeTranslation factorCoefficentHazard ratioWald test pvalLikelihool ratio pvalLogrank test pval# samples


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Translation factor and Gender


check button Differential gene expression between female and male. (Wilcoxon test, pval<0.05)
Cancer typeTranslation factorpvaladj.p

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Translation factor and Age


check button Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)
Cancer typeTranslation factorpvaladj.p

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Related Drugs


check button Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)
UniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases


check button Diseases associated with this translation factor.
(DisGeNet 4.0)
Disease IDDisease Name# PubMedsDisease source