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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: PABPC1 (NCBI Gene ID:26986)

Gene Summary

Gene Summary

Gene Information	Gene Name: PABPC1
	Gene ID: 26986
	Gene Symbol	PABPC1
	Gene ID	26986
	Gene Name	poly(A) binding protein cytoplasmic 1
	Synonyms	PAB1\|PABP\|PABP1\|PABPC2\|PABPL1
	Cytomap	8q22.3
	Type of Gene	protein-coding
	Description	polyadenylate-binding protein 1poly(A) binding protein, cytoplasmic 2
	Modification date	20200313
	UniProtAcc	P11940

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0017148	Negative regulation of translation
GO:0006417	Regulation of translation
GO:0045727	Positive regulation of translation
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PABPC1	GO:2000623	negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	18447585

Inferred gene age of translation factor.

Gene

Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25

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Translation Studies in PubMed

We searched PubMed using 'PABPC1[title] AND translation [title] AND human.'

Gene	Title	PMID
PABPC1	Domain-functional analyses of PIWIL1 and PABPC1 indicate their synergistic roles in protein translation via 3'-UTRs of meiotic mRNAs	29701755

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000318607	101717153	101717284	Frame-shift
ENST00000318607	101719114	101719225	In-frame
ENST00000318607	101721686	101721959	In-frame
ENST00000318607	101724879	101725017	In-frame
ENST00000318607	101725314	101725409	Frame-shift
ENST00000318607	101727689	101727829	Frame-shift
ENST00000318607	101730314	101730508	Frame-shift

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000318607	101719114	101719225	3502	2466	2576	636	445	482
ENST00000318607	101721686	101721959	3502	2102	2374	636	324	415
ENST00000318607	101724879	101725017	3502	1868	2005	636	246	292

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
P11940	324	415	1	636	Chain	ID=PRO_0000081698;Note=Polyadenylate-binding protein 1
P11940	445	482	1	636	Chain	ID=PRO_0000081698;Note=Polyadenylate-binding protein 1
P11940	246	292	1	636	Chain	ID=PRO_0000081698;Note=Polyadenylate-binding protein 1
P11940	246	292	191	268	Domain	Note=RRM 3;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00176
P11940	324	415	294	370	Domain	Note=RRM 4;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00176
P11940	246	292	166	289	Region	Note=CSDE1-binding
P11940	324	415	385	385	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:24129315;Dbxref=PMID:24129315
P11940	445	482	455	455	Modified residue	Note=Omega-N-methylated arginine%3B by CARM1%3B partial;Ontology_term=ECO:0000305;evidence=ECO:0000305\|PubMed:11850402;Dbxref=PMID:11850402
P11940	445	482	460	460	Modified residue	Note=Omega-N-methylated arginine%3B by CARM1%3B partial;Ontology_term=ECO:0000305;evidence=ECO:0000305\|PubMed:11850402;Dbxref=PMID:11850402
P11940	445	482	475	475	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P29341
P11940	445	482	481	481	Modified residue	Note=Omega-N-methylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:24129315;Dbxref=PMID:24129315
P11940	445	482	447	535	Alternative sequence	ID=VSP_009846;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.5
P11940	445	482	455	455	Mutagenesis	Note=Greatly reduces methylation by CARM1 (in vitro)%3B when associated with A-460. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:11850402;Dbxref=PMID:11850402
P11940	445	482	460	460	Mutagenesis	Note=Greatly reduces methylation by CARM1 (in vitro)%3B when associated with A-455. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:11850402;Dbxref=PMID:11850402
P11940	324	415	410	410	Sequence conflict	Note=M->I;Ontology_term=ECO:0000305;evidence=ECO:0000305

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
CHOL	PABPC1	-4.56272528815353	0.00390625
BLCA	PABPC1	1.31485302792746	0.0180816650390625
LIHC	PABPC1	-1.72076961362188	2.98009622125841e-06
PRAD	PABPC1	-2.10200318363476	8.55379952759014e-07

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
GBM	PABPC1	hsa-miR-129-5p	80	-1	0.0166666666666667

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
LUAD	PABPC1	3	2	0.0261496958201642	0.607756220043573	0.575845753512133	0.101999235959998	0.205900797825902
MESO	PABPC1	3	2	0.00592467327120719	0.609791756272401	0.579193650793651	-0.0982997583474645	0.237052891422168
OV	PABPC1	3	2	0.00158020936178883	0.616159380692168	0.546232748538012	-0.406339790076561	-0.197116729746288

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
MESO	PABPC1	0.082225111	0.012885909
UCEC	PABPC1	0.103939679	0.030221746

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with PABPC1 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
TGCT	Cell metabolism gene	PABPC1	AZIN1	0.83817801	2.17E-42

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
THCA	PABPC1	GSPT1	1.07187187610031	0.000163107625527599
LIHC	PABPC1	ATXN2	-1.06935742657813	0.000995596959071839
KIRC	PABPC1	PAIP1	-5.71279064132007	0.00220467399393826
KICH	PABPC1	EIF4G1	-1.46656081150743	0.00612920522689819
PRAD	PABPC1	PAIP2	-1.03296562711068	0.00620723523605432
THCA	PABPC1	ATXN2	-1.20023510959268	0.0179673415067429
COAD	PABPC1	ATXN2	-1.2576263132979	0.0334101617336274
ESCA	PABPC1	EIF4A1	-1.24538073199285	0.0419921875
BRCA	PABPC1	PAIP1	1.33783668607252	1.59729685534959e-08
PRAD	PABPC1	ATXN2	-1.04209995181407	1.98483018175684e-05
BRCA	PABPC1	EIF4B	-2.16032742029696	2.35556737304054e-22
BRCA	PABPC1	GSPT1	2.24014219081575	2.76767634190133e-17
BRCA	PABPC1	TNRC6A	-1.24656754002514	3.76762765813611e-06
KICH	PABPC1	EIF4E	1.61675210562671	6.55651092529297e-06
KIRC	PABPC1	TNRC6C	1.3512001263532	7.52485613123653e-05
KIRC	PABPC1	EIF4B	1.14997140510474	7.59366366705366e-09
KICH	PABPC1	EIF4A1	1.14485583309571	8.16583633422851e-06

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with PABPC1

ANAPC5, EIF4A2, IKBKE, PINX1, DYNLL1, PUF60, BCAR3, PAN2, UPF1, ETF1, PAN3, CNOT7, TOB1, EIF4B, PXN, PAIP1, GNB2L1, PAIP2, EIF4A1, GSPT2, GSPT1, EIF4G1, EIF4G3, HNRNPA1, AIRE, GIGYF2, H2AFX, PRMT6, tat, HNRNPD, Mapk13, HDAC5, STAU1, HNRNPK, YWHAG, Nhp2l1, Ybx1, AI837181, PCBP1, PCBP2, SREK1, NDRG1, ELAVL1, ARRB2, SIRT7, ZFP36, NCL, SH3KBP1, TSG101, TNRC6A, TNRC6B, TNRC6C, ATXN2, IGBP1, PPP2CA, NFX1, PABPC1, UBR5, CUL3, CUL4A, CUL4B, CUL5, CUL2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, NEDD8, CHAF1A, CNOT6, TOB2, MEX3B, MEX3A, MEX3C, BRCA1, SMAD3, PAIP2B, FBXO6, SYNCRIP, HNRNPU, HNRNPR, SNRNP200, DHX15, SNW1, ILF3, EEF1A1, RPS21, RPS4X, RPSA, RPS28, RPL4, RPL7, RPL7A, RPL13, RALY, SNRPD3, SART1, PRPF3, SNRPA, RPL5, EEF2, ATP6V1B2, ATP5A1, ESR1, HBB, USP10, G3BP1, Usp10, FN1, VCAM1, U2AF1, RBM4, IFIT1, IFIT2, IFIT3, AGO1, AGO2, IL7R, UBL4A, ITGA4, MAPKAPK2, SMG1, RBM8A, CD81, IGSF8, ICAM1, RUVBL1, TERT, BAG3, CSF2, TARDBP, CLK3, SRPK2, SRPK1, CLK2, ITCH, WBP4, APBB1, PIN1, WWOX, APEX1, P4HB, GNPDA1, SGTA, UBA1, PSMD9, TMOD3, rev, RPA1, RPA2, RPA3, HAUS1, CEP250, TP53, WWP2, SMG6, R3HCC1L, TDRD3, CUL7, OBSL1, CCDC8, ZMYND11, FBXW11, MAEL, ACAT2, CSTF2, DDX19A, EEF1G, FDPS, G3BP2, HSPA8, KIN, LUC7L2, MIF, MSI2, NHP2L1, ORC4, ALYREF, ATXN2L, BRIX1, CSTF3, DDX39A, DDX39B, EEF1A2, EIF4E, PFAS, PHGDH, POLE, RAE1, RPL13A, RPL18, RPL35, SFN, SKIV2L2, UAP1, PAPOLA, PAPOLB, PDCD6, PLRG1, PREP, PRPF8, RPL10A, RPL11, RPL14, RPL15, RPL17, RPL18A, RPL27, RPL27A, RPL3, RPL37A, RPL39, RPL6, RPLP0, RPLP2, RPS16, RPS3A, RPS6, RPS8, SERBP1, SF3A1, SUMO1, NTRK1, XPO1, HIST1H3E, RPL10, Gspt1, GAN, SKI, CRY1, MKRN1, MCM2, U2AF2, Zfp36, ELAVL2, TRA2A, SNRNP70, CYLD, COX15, DLD, DLST, DNM1L, HSD17B10, PARK7, PDHA1, VDAC1, TRIM25, PRNP, DCAF4L2, CFTR, ASCC3, FBXO7, IQGAP1, TMPO, ACO2, API5, BMP4, CTNNB1, PPIE, YAP1, GSK3A, KRAS, UBE2L6, EFTUD2, AAR2, PIH1D1, RPTOR, LARP1, TNIP2, CHD3, CHD4, RNF31, TNF, RIOK1, HEXIM1, MEPCE, LARP7, RUNX1, PPT1, HERC2, SNAI1, AGR2, RECQL4, REST, ZFP36L2, MYC, CDK9, Prkaa1, Prkab1, RPS6KB2, CDK5RAP2, USP5, USP13, KIAA1429, SRSF3, ATG16L1, ACTC1, PHB, FAF1, RBX1, ORF1, TET2, MAPT, NR2C2, UBQLN2, PPP1CC, ZBTB10, HDAC2, ZFYVE21, AGRN, BMH2, BMH1, FUS, TAF15, MATR3, ITFG1, GSK3B, ARAF, PPP1CA, N, BIRC3, UBAP2L, BRD7, HTT, CMTR1, ARIH2, PLEKHA4, PINK1, TFCP2, FANCD2, HCVgp1, LINC01554, ORF50, AXL, DUSP1, GAB1, MTA2, SRC, ERBB2, LHX1, KMT2C, NSD1, CDCA5, CELF1, CPEB4, DAZL, FAM120A, FUBP3, HELZ, IGF2BP1, IGF2BP2, LARP4B, LSM12, MKRN2, MOV10, NUFIP2, AGO3, AKAP1, ALG13, CASC3, CNOT1, DDX6, HNRNPA2B1, HNRNPA3, HNRNPL, LARP1B, LARP4, FAM195A, OTUD4, PABPC4, PRRC2A, PRRC2B, PRRC2C, PUM1, PUM2, R3HDM1, R3HDM2, RBMS1, RBMS2, RBMX, RC3H1, RC3H2, SECISBP2, SMAP2, SMG7, SRRM2, SRSF1, SRSF9, TDRD7, TOP3B, TRA2B, TYMS, YTHDF1, YTHDF2, YTHDF3, ZCCHC3, UNK, ZC3HAV1, BCL2L2-PABPN1, HNRNPAB, HNRNPDL, FAM195B, NCBP1, CAPRIN1, PRMT1, RTCB, STAU2, UBAP2, RBM47, YBX3, CNOT3, RQCD1, TIAL1, DUX4, CIT, ANLN, AURKB, CHMP4B, CHMP4C, ECT2, KIF14, KIF20A, KIF23, PRC1, IFI16, MNDA, LRRC59, NDN, BRD4, NUPR1, RBM45, Apc2, RBM39, FBP1, LGALS9, BKRF1, LIN28A, SETD8, RPL36, DCP1B, DCP1A, EDC3, HNRNPC, HIST1H2AI, YBX1, CBX6, H1FX, PRKACA, MKRN3, UNKL, GLE1, OGT, BAG5, DDRGK1, SPOP, AR, ISG15, PARK2, UFL1, NR4A1, MAPRE1, RPS20, FZR1, UBC, WDR5, NUDCD2, NAA40, ZC3H11A, PRR3, PABPC5, APOBEC3D, BTF3, EP300, FGD5, RCHY1, SQSTM1, CPEB1, RB1CC1, KLF4, ZEB1,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
PABPC1	chr8	101715587	T	TTTTAAACAGTTGGAACACCAGTGG	Insertion	not_provided	CIC-DUX_Sarcoma	SO:0001574\|splice_acceptor_variant	SO:0001574\|splice_acceptor_variant
PABPC1	chr8	101717292	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
PABPC1	chr8	101721407	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PABPC1	chr8	101725026	C	CA	Duplication	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
PABPC1	chr8	101730120	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
PABPC1	ACC	chr8	101724606	101724606	G	A	Missense_Mutation	p.T319I	24
PABPC1	LGG	chr8	101721933	101721933	T	-	Frame_Shift_Del	p.K333fs	11
PABPC1	LGG	chr8	101725000	101725000	G	A	Silent	p.N252N	10
PABPC1	CESC	chr8	101719121	101719121	G	A	Missense_Mutation		8
PABPC1	BLCA	chr8	101730110	101730110	A	C	Missense_Mutation		6
PABPC1	ESCA	chr8	101719226	101719226	C	G	Splice_Site	.	6
PABPC1	BLCA	chr8	101730036	101730037	-	C	Frame_Shift_Ins	p.E156fs	6
PABPC1	SKCM	chr8	101718929	101718929	G	A	Missense_Mutation	p.R518C	6
PABPC1	KIRC	chr8	101724994	101724995	-	A	Frame_Shift_Ins	p.R254fs	4
PABPC1	BRCA	chr8	101716544	101716544	G	A	Silent	p.T631	4
PABPC1	SKCM	chr8	101730087	101730087	G	A	Silent	p.G139G	4
PABPC1	BRCA	chr8	101717869	101717869	C	G	Missense_Mutation	p.L545F	4
PABPC1	LIHC	chr8	101733713	101733713	C	G	Silent	p.P33P	3
PABPC1	LUAD	chr8	101719186	101719186	G	A	Missense_Mutation	p.P459L	3
PABPC1	UCS	chr8	101727709	101727709	C	A	Missense_Mutation	p.K208N	3
PABPC1	BLCA	chr8	101717220	101717220	C	T	Missense_Mutation		3
PABPC1	LUAD	chr8	101718960	101718960	G	A	Silent	p.T507T	3
PABPC1	PAAD	chr8	101721953	101721953	T	A	Missense_Mutation	p.M327L	3
PABPC1	ESCA	chr8	101730362	101730362	C	T	Missense_Mutation	p.A114T	3
PABPC1	BRCA	chr8	101719153	101719153	G	A	Missense_Mutation	p.S470F	3
PABPC1	PAAD	chr8	101730110	101730110	A	C	Missense_Mutation	p.C132G	3
PABPC1	BRCA	chr8	101733617	101733617	A	T	Splice_Site	e1+2	3
PABPC1	HNSC	chr8	101733737	101733737	C	G	Silent	p.A25A	2
PABPC1	LIHC	chr8	101718907	101718907	T	C	Missense_Mutation		2
PABPC1	SKCM	chr8	101733795	101733795	G	A	Missense_Mutation	p.P6L	2
PABPC1	UCEC	chr8	101730486	101730486	C	A	Missense_Mutation	p.M72I	2
PABPC1	ESCA	chr8	101725016	101725016	G	T	Missense_Mutation	p.A247D	2
PABPC1	SKCM	chr8	101717162	101717162	G	A	Missense_Mutation	p.R604C	2
PABPC1	STAD	chr8	101719160	101719160	G	A	Missense_Mutation		2
PABPC1	KIRC	chr8	101719135	101719135	A	T	Missense_Mutation	p.V476D	2
PABPC1	LIHC	chr8	101730010	101730010	T	C	Missense_Mutation		2
PABPC1	PCPG	chr8	101719201	101719201	A	G	Missense_Mutation		2
PABPC1	BRCA	chr8	101730420	101730420	G	C	Silent	p.R94	2
PABPC1	SKCM	chr8	101717163	101717163	G	A	Silent	p.L603L	2
PABPC1	HNSC	chr8	101717819	101717819	A	G	Missense_Mutation		2
PABPC1	UCEC	chr8	101717249	101717249	G	T	Missense_Mutation	p.P575T	2
PABPC1	STAD	chr8	101719160	101719160	G	A	Missense_Mutation	p.P468S	2
PABPC1	BLCA	chr8	101721413	101721413	A	G	Silent	p.I428I	2
PABPC1	UCEC	chr8	101721360	101721360	C	T	Splice_Site	e9+1	2
PABPC1	STAD	chr8	101719036	101719036	A	-	Splice_Site	.	2
PABPC1	LUAD	chr8	101733732	101733732	A	G	Missense_Mutation	p.L27P	2
PABPC1	SARC	chr8	101721931	101721931	C	T	Missense_Mutation		2
PABPC1	BLCA	chr8	101719200	101719200	G	A	Silent	p.I454I	2
PABPC1	LIHC	chr8	101717231	101717231	T	-	Frame_Shift_Del	p.I581fs	2
PABPC1	UCEC	chr8	101721709	101721709	T	C	Missense_Mutation	p.Y408C	2
PABPC1	STAD	chr8	101721808	101721808	T	C	Missense_Mutation	p.Q375R	2
PABPC1	LIHC	chr8	101718987	101718987	G	A	Silent		2
PABPC1	SARC	chr8	101721932	101721932	C	T	Missense_Mutation		2
PABPC1	BLCA	chr8	101717853	101717853	C	T	Missense_Mutation	p.A551T	2
PABPC1	ESCA	chr8	101725016	101725016	G	T	Missense_Mutation		2
PABPC1	UCEC	chr8	101724661	101724661	G	T	Missense_Mutation	p.L301I	2
PABPC1	PAAD	chr8	101727716	101727716	C	T	Missense_Mutation	p.R206H	2
PABPC1	LUAD	chr8	101721762	101721762	T	A	Silent	p.R390R	2
PABPC1	LIHC	chr8	101719004	101719004	G	A	Missense_Mutation		2
PABPC1	ESCA	chr8	101721918	101721918	T	C	Silent		2
PABPC1	CESC	chr8	101719024	101719024	G	A	Missense_Mutation		2
PABPC1	UCEC	chr8	101727717	101727717	G	A	Missense_Mutation	p.R206C	2
PABPC1	LIHC	chr8	101730043	101730043	G	C	Missense_Mutation		2
PABPC1	UCEC	chr8	101727818	101727818	C	T	Missense_Mutation	p.R172Q	2
PABPC1	LIHC	chr8	101730064	101730064	G	A	Missense_Mutation		2
PABPC1	UCEC	chr8	101730064	101730064	G	T	Missense_Mutation	p.T147K	2
PABPC1	PCPG	chr8	101730064	101730064	G	A	Missense_Mutation	p.T147M	2
PABPC1	ESCA	chr8	101733692	101733692	G	T	Silent	p.I40I	2
PABPC1	UCEC	chr8	101730421	101730421	C	T	Missense_Mutation	p.R94H	2
PABPC1	KIRC	chr8	101724674	101724674	A	G	Silent	p.L296L	2
PABPC1	BLCA	chr8	101733634	101733634	G	-	Frame_Shift_Del	p.Q61fs	1
PABPC1	ESCA	chr8	101725016	101725016	G	T	Splice_Site	p.A247_splice	1
PABPC1	UCEC	chr8	101718963	101718963	G	A	Silent	p.R506R	1
PABPC1	SKCM	chr8	101717274	101717274	C	G	Silent	p.L566L	1
PABPC1	BLCA	chr8	101721413	101721413	A	G	Silent		1
PABPC1	COAD	chr8	101724923	101724923	C	T	Missense_Mutation	p.R278H	1
PABPC1	KIRC	chr8	101718897	101718897	T	C	Silent	p.P528P	1
PABPC1	LUAD	chr8	101717279	101717279	G	A	Missense_Mutation	p.R565W	1
PABPC1	LGG	chr8	101717843	101717843	G	T	Missense_Mutation		1
PABPC1	MESO	chr8	101727773	101727773	G	T	Missense_Mutation		1
PABPC1	PCPG	chr8	101717279	101717279	G	A	Missense_Mutation		1
PABPC1	STAD	chr8	101733798	101733798	G	A	Missense_Mutation	p.A5V	1
PABPC1	BLCA	chr8	101724668	101724668	C	T	Silent		1
PABPC1	BLCA	chr8	101721698	101721712	CTGCCATGAAGTAAC	-	In_Frame_Del	p.GYFMA407del	1
PABPC1	ESCA	chr8	101721918	101721918	T	C	Silent	p.V338V	1
PABPC1	HNSC	chr8	101717845	101717845	G	A	Silent	p.A553A	1
PABPC1	UCEC	chr8	101724929	101724930	AG	-	Frame_Shift_Del	p.L276fs	1
PABPC1	UCS	chr8	101727709	101727709	C	A	Missense_Mutation		1
PABPC1	BLCA	chr8	101717195	101717195	G	C	Missense_Mutation		1
PABPC1	COAD	chr8	101724933	101724933	C	T	Missense_Mutation	p.E275K	1
PABPC1	OV	chr8	101790928	101790928	T	G	Missense_Mutation	p.N394H	1
PABPC1	STAD	chr8	101717277	101717277	C	T	Silent	p.R565R	1
PABPC1	BLCA	chr8	101721698	101721712	CTGCCATGAAGTAAC	-	In_Frame_Del		1
PABPC1	ESCA	chr8	101719226	101719226	C	G	Splice_Site	e10-1	1
PABPC1	GBM	chr8	101730507	101730507	C	T	Silent	p.A65_splice	1
PABPC1	KICH	chr8	101727801	101727801	C	T	Missense_Mutation	p.E178K	1
PABPC1	LIHC	chr8	101721828	101721828	A	C	Silent	p.A368A	1
PABPC1	UCEC	chr8	101724932	101724941	TCCGTCTGCC	-	Frame_Shift_Del	p.R272fs	1
PABPC1	STAD	chr8	101716620	101716621	-	A	Splice_Site	.	1
PABPC1	COAD	chr8	101725412	101725412	A	-	Splice_Site	.	1
PABPC1	LIHC	chr8	101717259	101717259	T	C	Splice_Site		1
PABPC1	READ	chr8	101721870	101721870	G	A	Silent	p.N354N	1
PABPC1	STAD	chr8	101733683	101733683	G	A	Silent	p.C43C	1
PABPC1	BLCA	chr8	101721811	101721811	C	T	Missense_Mutation		1
PABPC1	KICH	chr8	101733701	101733702	-	A	Frame_Shift_Ins	p.I37fs	1
PABPC1	LIHC	chr8	101718907	101718907	T	C	Missense_Mutation	p.N525S	1
PABPC1	BLCA	chr8	101717237	101717237	C	T	Missense_Mutation		1
PABPC1	COAD	chr8	101727768	101727768	C	A	Nonsense_Mutation	p.E189X	1
PABPC1	KIRP	chr8	101717893	101717893	A	G	Silent	p.V537V	1
PABPC1	LUAD	chr8	101721767	101721767	C	T	Missense_Mutation	p.V389I	1
PABPC1	LIHC	chr8	101727702	101727702	A	G	Missense_Mutation		1
PABPC1	PAAD	chr8	101725003	101725003	C	A	Missense_Mutation	p.M251I	1
PABPC1	SARC	chr8	101733775	101733775	G	T	Missense_Mutation		1
PABPC1	THCA	chr8	101721407	101721407	T	C	Silent		1
PABPC1	ESCA	chr8	101734271	101734271	G	C	Missense_Mutation		1
PABPC1	HNSC	chr8	101721705	101721705	G	T	Missense_Mutation		1
PABPC1	KICH	chr8	101733702	101733703	-	G	Frame_Shift_Ins	p.I37fs	1
PABPC1	LIHC	chr8	101724687	101724688	-	A	Splice_Site		1
PABPC1	SKCM	chr8	101721690	101721690	T	A	Silent	p.P414P	1
PABPC1	BLCA	chr8	101719200	101719200	G	A	Silent		1
PABPC1	COAD	chr8	101730455	101730455	G	A	Missense_Mutation	p.R83C	1
PABPC1	LGG	chr8	101733783	101733784	-	T	Frame_Shift_Ins	p.M10fs	1
PABPC1	LIHC	chr8	101730315	101730315	C	T	Silent		1
PABPC1	THCA	chr8	101730010	101730010	T	C	Missense_Mutation	p.D165G	1
PABPC1	ESCA	chr8	101733692	101733692	G	T	Silent		1
PABPC1	HNSC	chr8	101721709	101721709	T	A	Missense_Mutation		1
PABPC1	KICH	chr8	101733723	101733723	T	-	Frame_Shift_Del	p.K30fs	1
PABPC1	SKCM	chr8	101727727	101727727	C	T	Missense_Mutation	p.M202I	1
PABPC1	COAD	chr8	101733746	101733746	C	T	Silent	p.V22V	1
PABPC1	LUAD	chr8	101721902	101721902	C	T	Missense_Mutation	p.E344K	1
PABPC1	THCA	chr8	101725401	101725401	A	C	Missense_Mutation	p.L218V	1
PABPC1	KICH	chr8	101724623	101724624	-	A	Frame_Shift_Ins	p.E313fs	1
PABPC1	LIHC	chr8	101721904	101721904	G	-	Frame_Shift_Del	p.P343fs	1
PABPC1	SKCM	chr8	101730327	101730327	G	A	Silent	p.I125I	1
PABPC1	STAD	chr8	101730336	101730336	A	C	Missense_Mutation	p.F122L	1
PABPC1	BLCA	chr8	101717853	101717853	C	T	Missense_Mutation		1
PABPC1	DLBC	chr8	101721705	101721705	G	T	Missense_Mutation	p.F409L	1
PABPC1	LGG	chr8	101724636	101724636	C	T	Missense_Mutation	p.R309H	1
PABPC1	HNSC	chr8	101725401	101725401	A	C	Missense_Mutation		1
PABPC1	SARC	chr8	101721727	101721727	G	A	Missense_Mutation		1
PABPC1	THCA	chr8	101719214	101719214	T	C	Missense_Mutation	p.M450V	1
PABPC1	BLCA	chr8	101733709	101733709	C	A	Missense_Mutation	p.G35W	1
PABPC1	KICH	chr8	101724626	101724627	TT	-	Frame_Shift_Del	p.K312fs	1
PABPC1	LIHC	chr8	101724979	101724979	T	-	Frame_Shift_Del	p.K259fs	1
PABPC1	SKCM	chr8	101721865	101721865	C	T	Missense_Mutation	p.R356K	1
PABPC1	PAAD	chr8	101727750	101727750	T	C	Missense_Mutation	p.I195V	1
PABPC1	STAD	chr8	101730329	101730329	T	G	Missense_Mutation	p.I125L	1
PABPC1	BLCA	chr8	101721409	101721409	G	T	Missense_Mutation		1
PABPC1	DLBC	chr8	101721785	101721785	T	A	Missense_Mutation	p.M383L	1
PABPC1	LGG	chr8	101733783	101733784	-	T	Frame_Shift_Ins	p.G10fs	1
PABPC1	LUSC	chr8	101719181	101719181	G	C	Missense_Mutation	p.P461A	1
PABPC1	HNSC	chr8	101733737	101733737	C	G	Silent		1
PABPC1	SARC	chr8	101733775	101733775	G	T	Missense_Mutation	p.L13I	1
PABPC1	THYM	chr8	101721721	101721721	G	T	Missense_Mutation	p.P404H	1
PABPC1	BLCA	chr8	101716565	101716565	C	G	Missense_Mutation	p.Q624H	1
PABPC1	ESCA	chr8	101724923	101724923	C	A	Missense_Mutation	p.R278L	1
PABPC1	ACC	chr8	101725319	101725319	T	G	Missense_Mutation	p.Q245P	1
PABPC1	KIRC	chr8	101725345	101725345	T	G	Silent	p.V236V	1
PABPC1	LIHC	chr8	101727739	101727739	A	-	Frame_Shift_Del	p.F198fs	1
PABPC1	SKCM	chr8	101725341	101725341	A	G	Missense_Mutation	p.F238L	1
PABPC1	PAAD	chr8	101730449	101730449	T	A	Missense_Mutation	p.M85L	1
PABPC1	STAD	chr8	101730341	101730341	C	G	Missense_Mutation	p.A121P	1
PABPC1	BLCA	chr8	101721424	101721424	G	C	Missense_Mutation		1
PABPC1	DLBC	chr8	101721960	101721960	C	A	Splice_Site	.	1
PABPC1	LUSC	chr8	101721391	101721391	G	A	Missense_Mutation	p.R436C	1
PABPC1	HNSC	chr8	101718959	101718959	C	A	Missense_Mutation		1
PABPC1	SARC	chr8	101721931	101721931	C	T	Missense_Mutation	p.G334E	1
PABPC1	UCEC	chr8	101721825	101721825	C	T	Silent	p.Q369Q	1
PABPC1	BLCA	chr8	101721811	101721811	C	T	Missense_Mutation	p.R374H	1
PABPC1	CESC	chr8	101733731	101733731	G	C	Silent		1
PABPC1	KIRC	chr8	101725366	101725366	T	A	Missense_Mutation	p.K229N	1
PABPC1	LIHC	chr8	101724975	101724975	T	-	Frame_Shift_Del	p.I261fs	1
PABPC1	SKCM	chr8	101721719	101721719	G	A	Missense_Mutation	p.P405S	1
PABPC1	STAD	chr8	101717899	101717899	A	T	Silent	p.P535P	1
PABPC1	BLCA	chr8	101733634	101733634	G	-	Frame_Shift_Del		1
PABPC1	DLBC	chr8	101730000	101730000	C	A	Splice_Site	.	1
PABPC1	LGG	chr8	101733783	101733784	-	T	Frame_Shift_Ins		1
PABPC1	LUSC	chr8	101717188	101717188	T	G	Missense_Mutation	p.H595P	1
PABPC1	HNSC	chr8	101718959	101718959	C	A	Missense_Mutation	p.V508F	1
PABPC1	LIHC	chr8	101730073	101730073	T	C	Missense_Mutation		1
PABPC1	SARC	chr8	101721932	101721932	C	T	Missense_Mutation	p.G334R	1
PABPC1	UCEC	chr8	101718919	101718919	T	C	Missense_Mutation	p.Q521R	1
PABPC1	BLCA	chr8	101718911	101718911	G	C	Missense_Mutation		1
PABPC1	COAD	chr8	101718995	101718995	C	T	Missense_Mutation	p.A496T	1
PABPC1	LUAD	chr8	101719131	101719131	C	G	Missense_Mutation	p.M477I	1
PABPC1	LGG	chr8	101724636	101724636	C	T	Missense_Mutation		1
PABPC1	LUSC	chr8	101724590	101724590	C	A	Missense_Mutation	p.K324_splice	1
PABPC1	PCPG	chr8	101721709	101721709	T	A	Missense_Mutation	p.Y408F	1
PABPC1	STAD	chr8	101716620	101716621	-	A	Splice_Site		1
PABPC1	BLCA	chr8	101716565	101716565	C	G	Missense_Mutation		1
PABPC1	DLBC	chr8	101730422	101730422	G	C	Missense_Mutation	p.R94G	1

Copy number variation (CNV) of PABPC1
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across PABPC1
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
90662	N/A	FN070067	ACVR2A	chr2	148616478	-	PABPC1	chr8	101698782	-
90662	N/A	ES315828	ANXA2	chr15	60641301	-	PABPC1	chr8	101715466	+
90662	N/A	T12081	CCT6A	chr7	56122112	-	PABPC1	chr8	101719225	-
90662	HNSC	TCGA-BA-A4IG	CLCC1	chr1	109505982	-	PABPC1	chr8	101717901	-
90662	N/A	BI496718	CLPTM1	chr19	45470608	-	PABPC1	chr8	101715144	+
90662	N/A	CV324685	CTNND1	chr11	57533552	+	PABPC1	chr8	101725766	-
90662	UVM	TCGA-V4-A9E7-01A	EEF2	chr19	3972316	-	PABPC1	chr8	101734220	-
90662	N/A	BI492138	EPC1	chr10	32573517	+	PABPC1	chr8	101715145	+
90662	N/A	EC575644	ERBB4	chr2	212352426	-	PABPC1	chr8	101719007	-
90662	STAD	TCGA-CD-A486-01A	FARP1	chr13	99030172	+	PABPC1	chr8	101725409	-
90662	STAD	TCGA-HU-A4GY-01A	FKBP15	chr9	115969492	-	PABPC1	chr8	101715587	-
90662	N/A	DA592957	HLA-DQB1	chr6	32629873	-	PABPC1	chr8	101733671	-
90662	COAD	TCGA-AA-A03J-01A	INSM1	chr20	20349019	+	PABPC1	chr8	101719188	-
90662	N/A	T12082	KIF26B	chr1	245788245	+	PABPC1	chr8	101715487	+
90662	N/A	AW629981	MFGE8	chr15	89445796	-	PABPC1	chr8	101733960	-
90662	STAD	TCGA-CD-8525-01A	NUP210	chr3	13393379	-	PABPC1	chr8	101715587	-
91830	N/A	BG034038	PABPC1	chr8	101733895	-	BAIAP2L2	chr22	38485289	-
77797	N/A	AW020442	PABPC1	chr8	101715144	-	C8orf44-SGK3	chr8	67618281	-
92652	N/A	AW021563	PABPC1	chr8	101715144	-	CLPTM1	chr19	45470608	+
80053	BRCA	TCGA-A2-A0CU-01A	PABPC1	chr8	101716525	-	CNGB3	chr8	87623899	-
68181	N/A	BQ348968	PABPC1	chr8	101721898	-	DPP4	chr2	162862283	-
97966	N/A	N75867	PABPC1	chr8	101715144	-	EDIL3	chr5	83279585	-
83038	N/A	BI495683	PABPC1	chr8	101715144	-	FBN3	chr19	8169046	+
96833	STAD	TCGA-SW-A7EA	PABPC1	chr8	101730000	-	GRSF1	chr4	71691148	-
68118	N/A	EC570213	PABPC1	chr8	101706349	+	HMGXB3	chr5	149432283	-
101849	KIRC	TCGA-CZ-4858-01A	PABPC1	chr8	101727690	-	HNRNPH3	chr10	70098897	+
99611	LGG	TCGA-DH-A66G-01A	PABPC1	chr8	101724880	-	KHDRBS3	chr8	136554897	+
62228	N/A	AW021194	PABPC1	chr8	101715144	-	LINC00589	chr8	29533088	-
62228	N/A	BI496719	PABPC1	chr8	101715144	-	LUZP2	chr11	24876212	+
82449	N/A	AA731281	PABPC1	chr8	101733727	-	MGEA5	chr10	103578141	-
62228	N/A	DB265528	PABPC1	chr8	101734039	-	MTMR14	chr3	9691293	+
95595	N/A	BG928171	PABPC1	chr8	101733914	-	NR4A1	chr12	52451247	+
99231	N/A	BG030633	PABPC1	chr8	101715148	-	NUP210L	chr1	153989446	+
90662	N/A	AA639905	PABPC1	chr8	101717165	-	PABPC1	chr8	101715557	+
90662	N/A	AW880952	PABPC1	chr8	101721812	-	PABPC1	chr8	101725017	-
90662	N/A	EC505458	PABPC1	chr8	101715248	+	PABPC1	chr8	101715234	-
96630	N/A	BE838573	PABPC1	chr8	101718879	-	PDS5A	chr4	39975062	-
96630	N/A	BI860864	PABPC1	chr8	101715472	-	PDS5A	chr4	39975062	-
97409	SARC	TCGA-FX-A2QS	PABPC1	chr8	101716524	-	PEX13	chr2	61258553	+
91493	BRCA	TCGA-A8-A07O-01A	PABPC1	chr8	101717154	-	RLIM	chrX	73803072	-
91493	GBM	TCGA-06-5858-01A	PABPC1	chr8	101718993	-	RLIM	chrX	73803327	-
91493	N/A	AX341383	PABPC1	chr8	101718879	-	RLIM	chrX	73803377	-
103283	COAD	TCGA-AA-A03F-01A	PABPC1	chr8	101733796	-	RPLP0	chr12	120636800	-
95311	Non-Cancer	ERR315465	PABPC1	chr8	101730411	-	RPS23	chr5	81573671	-
96178	N/A	AA535481	PABPC1	chr8	101715145	-	SETD2	chr3	47087009	+
88070	N/A	EC561860	PABPC1	chr8	101715485	+	SUMF1	chr3	4435326	+
101717	N/A	AW020548	PABPC1	chr8	101715144	-	TPM4	chr19	16207782	-
98002	N/A	BE612624	PABPC1	chr8	101715249	+	VCP	chr9	35060402	-
89829	STAD	TCGA-CG-5724-01A	PABPC1	chr8	101734128	-	VDAC1	chr5	133340379	-
96479	BLCA	TCGA-4Z-AA7S-01A	PABPC1	chr8	101716525	-	VPS13B	chr8	100779002	+
101126	UCEC	TCGA-AX-A3FV	PABPC1	chr8	101733618	-	ZFPM2	chr8	106431371	+
101126	UCEC	TCGA-AX-A3FV-01A	PABPC1	chr8	101733619	-	ZFPM2	chr8	106431372	+
102775	UCEC	TCGA-EY-A4KR-01A	PABPC1	chr8	101716525	-	ZNF706	chr8	102190615	-
90662	N/A	AW579672	PDS5A	chr4	39974484	-	PABPC1	chr8	101715585	-
90662	BRCA	TCGA-A2-A04Y-01A	RBM38	chr20	55968389	+	PABPC1	chr8	101721959	-
90662	N/A	DW419798	RFX3	chr9	3524905	-	PABPC1	chr8	101719175	-
90662	LUAD	TCGA-97-7937-01A	RLIM	chrX	73802937	-	PABPC1	chr8	101717224	-
90662	N/A	AW602061	RLIM	chrX	73803377	+	PABPC1	chr8	101716525	+
90662	N/A	AX351410	RLIM	chrX	73803377	+	PABPC1	chr8	101718879	+
90662	N/A	FN167024	RLIM	chrX	73803170	+	PABPC1	chr8	101719187	+
90662	N/A	HO004772	RLIM	chrX	73803377	+	PABPC1	chr8	101717152	+
90662	BLCA	TCGA-GV-A3JW-01A	RNF19A	chr8	101287181	-	PABPC1	chr8	101730508	-
90662	N/A	BD311423	SAP130	chr2	128785195	-	PABPC1	chr8	101733593	-
90662	N/A	AA894515	SLC9B1	chr4	103819661	-	PABPC1	chr8	101715144	+
90662	BLCA	TCGA-E7-A5KE-01A	SNX31	chr8	101608867	-	PABPC1	chr8	101724685	-
90662	BLCA	TCGA-E7-A5KE-01A	SNX31	chr8	101608867	-	PABPC1	chr8	101725017	-
90662	BLCA	TCGA-G2-A3VY-01A	SNX31	chr8	101642555	-	PABPC1	chr8	101698522	-
90662	N/A	EC496448	SSTR2	chr17	71171040	-	PABPC1	chr8	101715159	+
90662	READ	TCGA-AG-3882	TCF25	chr16	89958664	+	PABPC1	chr8	101717900	-
90665	STAD	TCGA-HU-A4G6	THOC2	chrX	122761543	-	PABPC1	chr8	101734315	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
TGCT	PABPC1	0.000567843903435975	0.016
KIRC	PABPC1	0.00173655335651324	0.047
LIHC	PABPC1	0.00312472186764723	0.081
KIRP	PABPC1	0.0254246600596576	0.64
ESCA	PABPC1	0.0299591973001949	0.72
LGG	PABPC1	0.0396906092791329	0.91

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LIHC	PABPC1	0.0127310413713713	0.37
LGG	PABPC1	0.000377199514682194	0.012
BRCA	PABPC1	2.68965810641073e-05	0.00089
PRAD	PABPC1	0.000621434910014083	0.019
SKCM	PABPC1	0.00510656313130331	0.15
OV	PABPC1	0.049859291788142	1
HNSC	PABPC1	0.0258385953130929	0.72

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0005684	Malignant neoplasm of urinary bladder	1	CTD_human
C0005695	Bladder Neoplasm	1	CTD_human
C0006142	Malignant neoplasm of breast	1	CTD_human
C0007138	Carcinoma, Transitional Cell	1	CTD_human
C0678222	Breast Carcinoma	1	CTD_human
C1257931	Mammary Neoplasms, Human	1	CTD_human
C4704874	Mammary Carcinoma, Human	1	CTD_human