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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: EIF2AK1 (NCBI Gene ID:27102)

Gene Summary

Gene Summary

Gene Information	Gene Name: EIF2AK1
	Gene ID: 27102
	Gene Symbol	EIF2AK1
	Gene ID	27102
	Gene Name	eukaryotic translation initiation factor 2 alpha kinase 1
	Synonyms	HCR\|HRI
	Cytomap	7p22.1
	Type of Gene	protein-coding
	Description	eukaryotic translation initiation factor 2-alpha kinase 1heme regulated initiation factor 2 alpha kinaseheme sensitive initiation factor 2a kinaseheme-controlled repressorheme-regulated eukaryotic initiation factor eIF-2-alpha kinaseheme-regulated in
	Modification date	20200313
	UniProtAcc	Q9BQI3

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0017148	Negative regulation of translation
GO:0006417	Regulation of translation
GO:0006413	Translational initiation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	EIF2AK1	GO:1990641	response to iron ion starvation	11036079

Inferred gene age of translation factor.

Gene

Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25

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Translation Studies in PubMed

We searched PubMed using 'EIF2AK1[title] AND translation [title] AND human.'

Gene	Title	PMID
EIF2AK1	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000199389	6068245	6068328	Frame-shift
ENST00000199389	6078190	6078302	Frame-shift
ENST00000199389	6080522	6080850	Frame-shift
ENST00000199389	6082563	6082624	Frame-shift
ENST00000199389	6084192	6084292	Frame-shift
ENST00000199389	6085701	6085782	In-frame
ENST00000199389	6089542	6089676	Frame-shift

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000199389	6085701	6085782	4480	697	777	630	183	210

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
LIHC	EIF2AK1	1.02895057766903	0.0117519726237409
HNSC	EIF2AK1	-1.50777865012306	8.09852713246075e-05

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
HNSC	EIF2AK1	1	2	0.0414189091470379	0.190374298540965	0.215079822129822	-0.994443167297018	-0.839442413395985

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
OV	EIF2AK1	-0.126240884	0.007583573

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with EIF2AK1 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type

Gene group

Translation factor

Correlated gene

Coefficient

Pvalue

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
THCA	EIF2AK1	ATF5	-3.6483772168245	0.000131811128007167
BLCA	EIF2AK1	NFE2L2	-1.76345192356642	0.000209808349609375
THCA	EIF2AK1	PPP1R15A	-2.18258608800368	0.000220116892613013
BLCA	EIF2AK1	PPP1R15A	-1.63289958656909	0.00026702880859375
LUSC	EIF2AK1	NFE2L2	1.20049933352781	0.000270957388175425
HNSC	EIF2AK1	ATF5	-2.87567105089705	0.000412285219226761
STAD	EIF2AK1	EPRS	-1.48171581324647	0.000789262883452143
LIHC	EIF2AK1	EIF2S3	-4.62530933210412	0.00154404530385922
KICH	EIF2AK1	EIF2S2	-1.06278646532411	0.00308787822723389
ESCA	EIF2AK1	NFE2L2	-1.51632950498811	0.0048828125
KICH	EIF2AK1	NFE2L2	-2.53310552704317	0.00507164001464844
KIRP	EIF2AK1	ATF5	-1.1895420041077	0.0093395933508873
PRAD	EIF2AK1	PPP1R15A	-2.47060915817754	0.0305494319135424
ESCA	EIF2AK1	EIF2S3	-1.31322237574718	0.0419921875
THCA	EIF2AK1	NFE2L2	-1.38043426729209	1.52415528924356e-07
BRCA	EIF2AK1	EIF2S2	-2.57303037687825	1.70212120584918e-09
BRCA	EIF2AK1	ATF5	-2.17324379867527	2.18160930117687e-12
LIHC	EIF2AK1	EPRS	-7.10731017811505	2.28054594243154e-08
STAD	EIF2AK1	NFE2L2	-2.32414070750512	2.31293961405754e-06
KIRC	EIF2AK1	ATF4	-2.05004013451381	2.37769366427877e-11
STAD	EIF2AK1	EIF2S2	-2.13186277769467	3.17529775202275e-05
LUSC	EIF2AK1	PPP1R15A	-3.6323939418678	4.80668566889666e-09
KIRC	EIF2AK1	NFE2L2	-2.23182480822215	7.34454893535006e-09
KIRC	EIF2AK1	ATF5	-2.37036362336938	8.228320553924e-07
LUAD	EIF2AK1	PPP1R15A	-6.07433219627145	8.25635334796511e-11
LIHC	EIF2AK1	ATF5	-1.0441589381352	9.39688124429159e-07
PRAD	EIF2AK1	EPRS	-1.76339127457265	9.52775218277559e-05

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with EIF2AK1

CDC37, HSP90AA1, LIG4, MDM2, FASLG, KIAA0141, CDK6, EAF1, DDX20, NAF1, ATRX, AP3B1, POLD1, RBM14, MFAP1, HSPA8, HIST1H1B, C12orf49, KDM1A,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
EIF2AK1	chr7	6068654	T	C	single_nucleotide_variant	Uncertain_significance	EIF2AK1-related_condition\|Leukoencephalopathy,_motor_delay,_spasticity,_and_dysarthria_syndrome	SO:0001583\|missense_variant	SO:0001583\|missense_variant
EIF2AK1	chr7	6078231	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
EIF2AK1	chr7	6078248	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
EIF2AK1	chr7	6089553	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
EIF2AK1	HNSC	chr7	6066461	6066461	T	C	Silent		5
EIF2AK1	HNSC	chr7	6089666	6089666	C	G	Missense_Mutation	p.Q96H	4
EIF2AK1	KIRP	chr7	6084205	6084205	T	G	Missense_Mutation	p.I240L	4
EIF2AK1	BRCA	chr7	6085747	6085747	T	A	Silent	p.I195	3
EIF2AK1	HNSC	chr7	6077129	6077129	T	C	Missense_Mutation	p.T420A	3
EIF2AK1	SKCM	chr7	6094294	6094294	G	A	Silent	p.L54L	3
EIF2AK1	HNSC	chr7	6085734	6085734	T	A	Missense_Mutation	p.I200F	3
EIF2AK1	UCEC	chr7	6080612	6080612	G	A	Missense_Mutation	p.P344S	3
EIF2AK1	STAD	chr7	6080770	6080770	C	T	Missense_Mutation	p.R291H	3
EIF2AK1	BLCA	chr7	6080762	6080762	C	T	Missense_Mutation	p.E294K	3
EIF2AK1	BRCA	chr7	6077156	6077156	C	T	Splice_Site	e11-1	3
EIF2AK1	SKCM	chr7	6084289	6084289	G	A	Silent	p.L212L	2
EIF2AK1	UCEC	chr7	6077114	6077114	C	A	Nonsense_Mutation	p.E425*	2
EIF2AK1	KIRP	chr7	6078295	6078296	-	A	Frame_Shift_Ins	p.Y376fs	2
EIF2AK1	STAD	chr7	6066556	6066556	G	A	Missense_Mutation	p.L523F	2
EIF2AK1	HNSC	chr7	6086667	6086667	C	G	Missense_Mutation	p.E169Q	2
EIF2AK1	UCEC	chr7	6082581	6082581	G	A	Silent	p.S258	2
EIF2AK1	KIRP	chr7	6078298	6078299	-	A	Frame_Shift_Ins	p.Q375fs	2
EIF2AK1	STAD	chr7	6066563	6066563	C	T	Silent	p.L520L	2
EIF2AK1	HNSC	chr7	6077066	6077066	G	A	Nonsense_Mutation	p.R441*	2
EIF2AK1	LUAD	chr7	6078292	6078292	T	C	Missense_Mutation	p.H377R	2
EIF2AK1	UCEC	chr7	6094179	6094179	T	G	Missense_Mutation	p.K92T	2
EIF2AK1	CESC	chr7	6068293	6068293	G	C	Missense_Mutation		2
EIF2AK1	STAD	chr7	6064312	6064312	C	T	Missense_Mutation	p.V629M	2
EIF2AK1	SKCM	chr7	6089631	6089631	G	A	Missense_Mutation	p.T108I	2
EIF2AK1	STAD	chr7	6066525	6066525	C	T	Missense_Mutation	p.R533Q	2
EIF2AK1	ESCA	chr7	6066405	6066406	-	AT	Frame_Shift_Ins	p.S573fs	2
EIF2AK1	LUAD	chr7	6094328	6094328	A	T	Missense_Mutation	p.D42E	2
EIF2AK1	KIRP	chr7	6084205	6084205	T	G	Missense_Mutation		2
EIF2AK1	ESCA	chr7	6066493	6066493	G	T	Missense_Mutation	p.Q544K	2
EIF2AK1	KIRC	chr7	6094303	6094303	T	C	Missense_Mutation	p.K51E	2
EIF2AK1	LUAD	chr7	6080534	6080534	C	A	Missense_Mutation	p.G370C	2
EIF2AK1	CESC	chr7	6068648	6068648	G	A	Missense_Mutation		2
EIF2AK1	SARC	chr7	6068553	6068553	C	T	Silent		2
EIF2AK1	BLCA	chr7	6086641	6086641	T	C	Silent	p.G177G	2
EIF2AK1	CESC	chr7	6068307	6068307	C	G	Missense_Mutation		2
EIF2AK1	UCEC	chr7	6066420	6066420	G	T	Nonsense_Mutation	p.S568*	2
EIF2AK1	BLCA	chr7	6084228	6084228	G	T	Missense_Mutation		2
EIF2AK1	UCEC	chr7	6068659	6068659	C	A	Missense_Mutation	p.R446I	2
EIF2AK1	UCEC	chr7	6077078	6077078	C	T	Missense_Mutation	p.G437R	2
EIF2AK1	BLCA	chr7	6098634	6098634	G	C	Missense_Mutation		2
EIF2AK1	STAD	chr7	6094220	6094220	G	A	Silent		2
EIF2AK1	HNSC	chr7	6066485	6066485	C	A	Silent	p.P546P	2
EIF2AK1	UCEC	chr7	6077087	6077087	G	A	Missense_Mutation	p.H434Y	2
EIF2AK1	GBM	chr7	6063079	6063079	G	A	Silent		1
EIF2AK1	KIRP	chr7	6078297	6078297	C	G	Missense_Mutation	p.Q375H	1
EIF2AK1	MESO	chr7	6063726	6063726	G	T	Missense_Mutation		1
EIF2AK1	STAD	chr7	6094220	6094220	G	A	Silent	p.H78H	1
EIF2AK1	THYM	chr7	6084265	6084265	C	T	Missense_Mutation	p.G220S	1
EIF2AK1	CESC	chr7	6066550	6066550	G	A	Nonsense_Mutation	p.Q525*	1
EIF2AK1	HNSC	chr7	6089554	6089554	T	A	Nonsense_Mutation	p.R134*	1
EIF2AK1	LIHC	chr7	6068567	6068567	T	C	Missense_Mutation		1
EIF2AK1	LUAD	chr7	6085729	6085729	C	T	Silent	p.K201K	1
EIF2AK1	BLCA	chr7	6086641	6086641	T	C	Silent		1
EIF2AK1	COAD	chr7	6089588	6089588	T	C	Silent	p.R122R	1
EIF2AK1	CESC	chr7	6066450	6066450	T	C	Missense_Mutation		1
EIF2AK1	GBM	chr7	6063151	6063151	G	A	Silent		1
EIF2AK1	MESO	chr7	6066416	6066416	C	A	Silent		1
EIF2AK1	LIHC	chr7	6080784	6080784	T	A	Silent	p.P286P	1
EIF2AK1	SKCM	chr7	6080834	6080834	T	C	Missense_Mutation	p.K269E	1
EIF2AK1	THYM	chr7	6068599	6068599	C	T	Missense_Mutation	p.C466Y	1
EIF2AK1	CESC	chr7	6068307	6068307	C	G	Missense_Mutation	p.R490T	1
EIF2AK1	HNSC	chr7	6080816	6080816	T	A	Missense_Mutation	p.S276C	1
EIF2AK1	LUAD	chr7	6089620	6089620	C	A	Nonsense_Mutation	p.E112*	1
EIF2AK1	BLCA	chr7	6080762	6080762	C	T	Missense_Mutation		1
EIF2AK1	COAD	chr7	6098685	6098685	C	T	Silent	p.K10K	1
EIF2AK1	CESC	chr7	6084230	6084230	G	T	Silent		1
EIF2AK1	HNSC	chr7	6066485	6066485	C	A	Silent		1
EIF2AK1	PCPG	chr7	6085711	6085711	A	C	Silent	p.V207V	1
EIF2AK1	LIHC	chr7	6064424	6064424	G	T	Silent	p.L591L	1
EIF2AK1	SKCM	chr7	6080809	6080809	G	A	Missense_Mutation	p.S277F	1
EIF2AK1	THYM	chr7	6098650	6098650	G	T	Missense_Mutation	p.A22D	1
EIF2AK1	CESC	chr7	6068648	6068648	G	A	Missense_Mutation	p.L450F	1
EIF2AK1	HNSC	chr7	6085709	6085709	C	T	Missense_Mutation	p.C208Y	1
EIF2AK1	SKCM	chr7	6098690	6098690	G	A	Missense_Mutation	p.R9C	1
EIF2AK1	BLCA	chr7	6078220	6078220	C	A	Missense_Mutation		1
EIF2AK1	COAD	chr7	6068293	6068293	G	T	Missense_Mutation	p.L494M	1
EIF2AK1	HNSC	chr7	6080616	6080616	C	G	Missense_Mutation		1
EIF2AK1	KIRP	chr7	6078297	6078298	CT	-	Frame_Shift_Del	p.375_376del	1
EIF2AK1	PRAD	chr7	6080676	6080676	G	T	Silent	p.T322T	1
EIF2AK1	LIHC	chr7	6078226	6078226	T	C	Missense_Mutation	p.N399S	1
EIF2AK1	THYM	chr7	6062967	6062967	C	T	Missense_Mutation		1
EIF2AK1	CESC	chr7	6084230	6084230	G	T	Silent	p.T231	1
EIF2AK1	DLBC	chr7	6080686	6080686	A	T	Missense_Mutation	p.L319H	1
EIF2AK1	LUAD	chr7	6098709	6098709	C	A	Missense_Mutation	p.Q2H	1
EIF2AK1	SKCM	chr7	6064348	6064348	C	T	Missense_Mutation	p.D617N	1
EIF2AK1	BLCA	chr7	6084235	6084235	G	A	Missense_Mutation	p.H230Y	1
EIF2AK1	CESC	chr7	6064351	6064351	G	C	Missense_Mutation		1
EIF2AK1	KIRP	chr7	6078297	6078297	C	G	Missense_Mutation	p.Q374H	1
EIF2AK1	READ	chr7	6077065	6077065	C	T	Missense_Mutation	p.R440Q	1
EIF2AK1	LIHC	chr7	6098639	6098639	C	T	Missense_Mutation	p.A26T	1
EIF2AK1	UCEC	chr7	6066366	6066366	G	T	Missense_Mutation	p.S586Y	1
EIF2AK1	COAD	chr7	6064398	6064398	T	G	Missense_Mutation	p.Q599P	1
EIF2AK1	BLCA	chr7	6080552	6080552	C	T	Missense_Mutation	p.E364K	1
EIF2AK1	SKCM	chr7	6077153	6077153	G	A	Missense_Mutation	p.P412S	1
EIF2AK1	CESC	chr7	6094176	6094176	C	T	Splice_Site		1
EIF2AK1	HNSC	chr7	6086667	6086667	C	G	Missense_Mutation		1
EIF2AK1	SARC	chr7	6080650	6080650	G	T	Missense_Mutation		1
EIF2AK1	STAD	chr7	6082613	6082613	C	T	Missense_Mutation	p.A248T	1
EIF2AK1	LIHC	chr7	6080772	6080772	T	-	Frame_Shift_Del	p.K290fs	1
EIF2AK1	SKCM	chr7	6078276	6078276	G	A	Silent	p.I381I	1
EIF2AK1	ACC	chr7	6078221	6078221	G	A	Missense_Mutation	p.R401W	1
EIF2AK1	COAD	chr7	6066469	6066469	T	A	Missense_Mutation	p.R551W	1
EIF2AK1	BLCA	chr7	6094332	6094332	G	C	Translation_Start_Site		1
EIF2AK1	SKCM	chr7	6080809	6080809	G	A	Missense_Mutation	p.S278F	1
EIF2AK1	HNSC	chr7	6077129	6077129	T	C	Missense_Mutation		1
EIF2AK1	LGG	chr7	6094277	6094277	G	T	Missense_Mutation	p.F59L	1
EIF2AK1	LIHC	chr7	6068649	6068649	A	-	Frame_Shift_Del	p.F449fs	1
EIF2AK1	SKCM	chr7	6077153	6077153	G	A	Missense_Mutation	p.P411S	1
EIF2AK1	UCEC	chr7	6082581	6082581	G	A	Silent	p.S258S	1
EIF2AK1	BLCA	chr7	6084235	6084235	G	A	Missense_Mutation		1
EIF2AK1	COAD	chr7	6066526	6066526	G	A	Nonsense_Mutation	p.R532X	1
EIF2AK1	ESCA	chr7	6066405	6066406	-	-	Frame_Shift_Ins		1
EIF2AK1	KIRC	chr7	6080672	6080672	C	T	Missense_Mutation	p.E324K	1
EIF2AK1	LUAD	chr7	6082607	6082607	C	A	Nonsense_Mutation	p.E250*	1
EIF2AK1	SKCM	chr7	6080834	6080834	T	C	Missense_Mutation	p.K270E	1
EIF2AK1	HNSC	chr7	6085734	6085734	T	A	Missense_Mutation		1
EIF2AK1	LGG	chr7	6078266	6078266	G	A	Silent	p.L386L	1
EIF2AK1	SARC	chr7	6064366	6064366	G	T	Missense_Mutation		1
EIF2AK1	THYM	chr7	6098650	6098650	G	T	Missense_Mutation		1
EIF2AK1	LUAD	chr7	6084286	6084286	G	A	Missense_Mutation	p.R213W	1
EIF2AK1	SKCM	chr7	6088449	6088449	G	A	Silent	p.I146I	1
EIF2AK1	COAD	chr7	6082571	6082571	C	A	Nonsense_Mutation	p.E261X	1
EIF2AK1	ESCA	chr7	6066493	6066493	G	T	Missense_Mutation		1
EIF2AK1	KIRC	chr7	6080728	6080728	A	T	Missense_Mutation	p.V305E	1
EIF2AK1	LUAD	chr7	6068591	6068591	T	C	Missense_Mutation	p.I469V	1
EIF2AK1	SKCM	chr7	6078216	6078216	G	A	Silent	p.G402G	1
EIF2AK1	CESC	chr7	6068293	6068293	G	C	Missense_Mutation	p.L495V	1
EIF2AK1	HNSC	chr7	6089666	6089666	C	G	Missense_Mutation		1
EIF2AK1	LGG	chr7	6078266	6078266	G	A	Silent		1
EIF2AK1	SARC	chr7	6068553	6068553	C	T	Silent	p.G481G	1
EIF2AK1	THYM	chr7	6068599	6068599	C	T	Missense_Mutation		1
EIF2AK1	LUAD	chr7	6068579	6068579	T	C	Missense_Mutation	p.N473D	1
EIF2AK1	SKCM	chr7	6085778	6085778	C	T	Missense_Mutation	p.R185K	1
EIF2AK1	BLCA	chr7	6077079	6077079	C	A	Missense_Mutation		1
EIF2AK1	COAD	chr7	6085740	6085740	T	-	Frame_Shift_Del	p.I198fs	1
EIF2AK1	BLCA	chr7	6098634	6098634	G	C	Missense_Mutation	p.I27M	1
EIF2AK1	ESCA	chr7	6066405	6066406	-	AT	Frame_Shift_Ins	p.C573fs	1
EIF2AK1	KIRP	chr7	6068606	6068606	G	C	Missense_Mutation	p.L464V	1
EIF2AK1	LUSC	chr7	6077058	6077058	C	G	Silent	p.L443L	1
EIF2AK1	SKCM	chr7	6078276	6078276	G	A	Silent	p.I382I	1
EIF2AK1	CESC	chr7	6066550	6066550	G	A	Nonsense_Mutation		1
EIF2AK1	HNSC	chr7	6080816	6080816	T	A	Missense_Mutation		1
EIF2AK1	LGG	chr7	6094277	6094277	G	T	Missense_Mutation		1
EIF2AK1	SARC	chr7	6080646	6080646	A	C	Silent		1
EIF2AK1	THYM	chr7	6084265	6084265	C	T	Missense_Mutation		1
EIF2AK1	LUAD	chr7	6078246	6078246	C	A	Missense_Mutation	p.W392C	1
EIF2AK1	COAD	chr7	6085761	6085761	G	A	Nonsense_Mutation	p.Q191X	1
EIF2AK1	ESCA	chr7	6066142	6066142	G	A	Missense_Mutation		1
EIF2AK1	LUSC	chr7	6089541	6089541	A	T	Splice_Site	p.Q137_splice	1
EIF2AK1	THYM	chr7	6068627	6068627	C	T	Missense_Mutation		1
EIF2AK1	CESC	chr7	6094176	6094176	C	T	Splice_Site	e2+1	1
EIF2AK1	LIHC	chr7	6089566	6089566	A	G	Missense_Mutation		1
EIF2AK1	SARC	chr7	6068553	6068553	C	T	Silent	p.G481	1
EIF2AK1	LUAD	chr7	6080771	6080771	G	A	Missense_Mutation	p.R291C	1
EIF2AK1	BLCA	chr7	6080552	6080552	C	T	Missense_Mutation		1
EIF2AK1	COAD	chr7	6086660	6086660	G	A	Missense_Mutation	p.A171V	1

Copy number variation (CNV) of EIF2AK1
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across EIF2AK1
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
96831	BRCA	TCGA-AQ-A04L-01B	AIMP2	chr7	6063282	-	EIF2AK1	chr7	6064405	-
96831	BRCA	TCGA-BH-A1FE-01A	AIMP2	chr7	6063022	+	EIF2AK1	chr7	6063468	-
96831	LUAD	TCGA-64-5774-01A	AIMP2	chr7	6063290	-	EIF2AK1	chr7	6064368	-
96831	LUSC	TCGA-43-3394-11A	AIMP2	chr7	6063440	-	EIF2AK1	chr7	6063978	-
96831	OV	TCGA-09-1667-01C	AIMP2	chr7	6062773	+	EIF2AK1	chr7	6063699	-
96831	OV	TCGA-09-1667-01C	AIMP2	chr7	6063287	+	EIF2AK1	chr7	6064162	-
96831	OV	TCGA-13-1481-01A	AIMP2	chr7	6063233	-	EIF2AK1	chr7	6064142	-
96831	OV	TCGA-13-1492-01A	AIMP2	chr7	6062863	+	EIF2AK1	chr7	6063606	-
96831	OV	TCGA-23-1024-01A	AIMP2	chr7	6063267	-	EIF2AK1	chr7	6063974	-
96831	OV	TCGA-24-1549-01A	AIMP2	chr7	6062821	-	EIF2AK1	chr7	6064320	-
96831	OV	TCGA-59-2352-01A	AIMP2	chr7	6057587	-	EIF2AK1	chr7	6063849	-
96831	OV	TCGA-61-1743-01A	AIMP2	chr7	6063222	-	EIF2AK1	chr7	6063698	-
96831	PRAD	TCGA-EJ-7123-01A	AIMP2	chr7	6057675	+	EIF2AK1	chr7	6064431	-
96831	STAD	TCGA-2H-A9GK-01A2	AIMP2	chr7	6063101	-	EIF2AK1	chr7	6064147	-
96831	STAD	TCGA-JY-A6FH-01A6	AIMP2	chr7	6062392	+	EIF2AK1	chr7	6063655	-
96831	STAD	TCGA-JY-A6FH-01A6	AIMP2	chr7	6063282	+	EIF2AK1	chr7	6064169	-
96831	STAD	TCGA-JY-A6FH-01A6	AIMP2	chr7	6063376	+	EIF2AK1	chr7	6064098	-
96831	STAD	TCGA-L5-A8NH-01A8	AIMP2	chr7	6063465	-	EIF2AK1	chr7	6064000	-
96831	STAD	TCGA-LN-A5U5-01A3	AIMP2	chr7	6063342	-	EIF2AK1	chr7	6064102	-
96831	STAD	TCGA-R6-A8WC-01A6	AIMP2	chr7	6062843	+	EIF2AK1	chr7	6063794	-
96831	STAD	TCGA-R6-A8WC-01A6	AIMP2	chr7	6063015	+	EIF2AK1	chr7	6063594	-
96831	STAD	TCGA-R6-A8WC-01A6	AIMP2	chr7	6063019	+	EIF2AK1	chr7	6063525	-
96831	STAD	TCGA-V5-AASX-11A8	AIMP2	chr7	6062777	+	EIF2AK1	chr7	6064078	-
96831	STAD	TCGA-VR-A8EX-01A1	AIMP2	chr7	6063167	-	EIF2AK1	chr7	6063690	-
96831	STAD	TCGA-VR-A8EX-01A1	AIMP2	chr7	6063382	+	EIF2AK1	chr7	6064216	-
96831	N/A	W25934	AIMP2	chr7	6063141	+	EIF2AK1	chr7	6062541	-
99304	N/A	AA641039	EIF2AK1	chr7	6062934	-	AIMP2	chr7	6063143	-
97715	UCEC	TCGA-PG-A914-01A	EIF2AK1	chr7	6077055	-	ANKS1B	chr12	99640642	-
94657	N/A	BP431008	EIF2AK1	chr7	6063402	-	CA2	chr8	86387587	+
58499	N/A	BF895041	EIF2AK1	chr7	6063719	-	DBNL	chr7	44085880	+
96784	LIHC	TCGA-ZS-A9CF-01A	EIF2AK1	chr7	6094177	-	GCK	chr7	44189458	-
96784	LIHC	TCGA-ZS-A9CF-01A	EIF2AK1	chr7	6094177	-	GCK	chr7	44189663	-
97483	LGG	TCGA-E1-A7Z2-01A	EIF2AK1	chr7	6064340	-	GLCCI1	chr7	8124527	+
89831	BRCA	TCGA-AR-A24V-01A	EIF2AK1	chr7	6094177	-	KDM3B	chr5	137717205	+
100576	PRAD	TCGA-V1-A8WV-01A	EIF2AK1	chr7	6077055	-	MAP2K5	chr15	68098984	+
61577	N/A	DA730893	EIF2AK1	chr7	6077124	-	MROH7-TTC4	chr1	55181545	+
100892	SARC	TCGA-JV-A75J-01A	EIF2AK1	chr7	6094177	-	PHF14	chr7	11091239	+
96177	STAD	TCGA-CD-A48C-01A	EIF2AK1	chr7	6063471	-	POU2F1	chr1	167385314	+
96831	BLCA	TCGA-DK-A6B5-01A	FSCN1	chr7	5633399	+	EIF2AK1	chr7	6066592	-
96831	STAD	TCGA-BR-A4J9-01A	PTCHD3P1	chr10	29704341	+	EIF2AK1	chr7	6089676	-
96831	STAD	TCGA-BR-8687	RAC1	chr7	6431672	+	EIF2AK1	chr7	6068663	-
96831	KIRC	TCGA-DV-5576	RNF216	chr7	5756346	-	EIF2AK1	chr7	6064432	-
96831	KIRC	TCGA-DV-5576-01A	RNF216	chr7	5756346	-	EIF2AK1	chr7	6064431	-
96831	KIRC	TCGA-DV-5576-01A	RNF216	chr7	5756347	-	EIF2AK1	chr7	6064432	-
96831	N/A	CB243839	TSNAXIP1	chr16	67848797	-	EIF2AK1	chr7	6063675	-
96831	N/A	Z17841	UNC45B	chr17	33495104	+	EIF2AK1	chr7	6064091	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
ESCA	EIF2AK1	0.000884304174853291	0.025
BRCA	EIF2AK1	0.00457987519774834	0.12
SKCM	EIF2AK1	0.0289790015044928	0.75
HNSC	EIF2AK1	0.0308980515607516	0.77

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUAD	EIF2AK1	0.0148373457384976	0.46
THCA	EIF2AK1	4.18373941270484e-06	0.00014
LGG	EIF2AK1	0.000521893932618594	0.017
PRAD	EIF2AK1	0.029822199307676	0.86
SARC	EIF2AK1	0.0225137170130526	0.68

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0002878	Anemia, Hemolytic	1	CTD_human
C0002879	Anemia, Hemolytic, Acquired	1	CTD_human
C0002889	Anemia, Microangiopathic	1	CTD_human
C0019193	Hepatitis, Toxic	1	CTD_human
C0035222	Respiratory Distress Syndrome, Adult	1	CTD_human
C0221021	Microangiopathic hemolytic anemia	1	CTD_human
C0400966	Non-alcoholic Fatty Liver Disease	1	CTD_human
C1262760	Hepatitis, Drug-Induced	1	CTD_human
C3241937	Nonalcoholic Steatohepatitis	1	CTD_human
C3658290	Drug-Induced Acute Liver Injury	1	CTD_human
C4277682	Chemical and Drug Induced Liver Injury	1	CTD_human
C4279912	Chemically-Induced Liver Toxicity	1	CTD_human