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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: GATC (NCBI Gene ID:283459)

Gene Summary

Gene Summary

Gene Information	Gene Name: GATC
	Gene ID: 283459
	Gene Symbol	GATC
	Gene ID	283459
	Gene Name	glutamyl-tRNA amidotransferase subunit C
	Synonyms	15E1.2
	Cytomap	12q24.31
	Type of Gene	protein-coding
	Description	glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrialglu-AdT subunit Cglutamyl-tRNA(Gln) amidotransferase, subunit C homolog
	Modification date	20200313
	UniProtAcc	O43716

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0032543	Mitochondrial translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	GATC	GO:0070681	glutaminyl-tRNAGln biosynthesis via transamidation	19805282

Inferred gene age of translation factor.

Gene

Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25

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Translation Studies in PubMed

We searched PubMed using 'GATC[title] AND translation [title] AND human.'

Gene	Title	PMID
GATC	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

ORF

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
LUAD	GATC	-3.31212457667297	0.000202139908061226
THCA	GATC	1.7309635515299	0.00553919070100212
COAD	GATC	2.11115021298901	4.08291816711426e-06

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
LUAD	GATC	-0.150417905	2.74E-05

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with GATC (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
DLBC	Cell metabolism gene	GATC	HMMR	0.838781632	9.90E-14
DLBC	CGC	GATC	STIL	0.805904954	4.85E-12
DLBC	CGC	GATC	BRCA2	0.821347298	8.60E-13
DLBC	Epifactor	GATC	TADA2A	0.803593348	6.20E-12
DLBC	Epifactor	GATC	BRCA2	0.821347298	8.60E-13
DLBC	Epifactor	GATC	TOP2A	0.843590165	5.21E-14
DLBC	IUPHAR	GATC	TOP2A	0.843590165	5.21E-14
DLBC	TF	GATC	ZNF689	0.839806856	8.65E-14
DLBC	TF	GATC	FOXM1	0.862076545	3.56E-15
DLBC	TSG	GATC	BRCA2	0.821347298	8.60E-13
KICH	Epifactor	GATC	REST	0.810673097	2.11E-22
KICH	IUPHAR	GATC	DPP8	0.807007655	4.55E-22
KICH	TF	GATC	REST	0.810673097	2.11E-22
KIRP	Cell metabolism gene	GATC	MGAT5	0.808543245	6.51E-76
KIRP	Cell metabolism gene	GATC	NCOA2	0.821101553	3.63E-80
KIRP	Cell metabolism gene	GATC	MAN2A1	0.824198502	2.88E-81
KIRP	Cell metabolism gene	GATC	PRKAR2A	0.834779905	3.39E-85
KIRP	Cell metabolism gene	GATC	PAFAH1B2	0.835362856	2.02E-85
KIRP	CGC	GATC	STRN	0.800094808	3.17E-73
KIRP	CGC	GATC	NCOA2	0.821101553	3.63E-80
KIRP	CGC	GATC	ASXL2	0.834847985	3.19E-85
KIRP	CGC	GATC	PAFAH1B2	0.835362856	2.02E-85
KIRP	Epifactor	GATC	REST	0.804167286	1.67E-74
KIRP	Epifactor	GATC	ATF2	0.81115457	9.03E-77
KIRP	Epifactor	GATC	NCOA2	0.821101553	3.63E-80
KIRP	Epifactor	GATC	ASXL2	0.834847985	3.19E-85
KIRP	IUPHAR	GATC	SLC30A6	0.810111814	1.99E-76
KIRP	IUPHAR	GATC	DPP8	0.813828733	1.16E-77
KIRP	IUPHAR	GATC	IDE	0.820641594	5.27E-80
KIRP	IUPHAR	GATC	NCOA2	0.821101553	3.63E-80
KIRP	IUPHAR	GATC	PRKAR2A	0.834779905	3.39E-85
KIRP	IUPHAR	GATC	SCYL2	0.848136802	1.42E-90
KIRP	Kinase	GATC	SCYL2	0.848136802	1.42E-90
KIRP	TF	GATC	REST	0.804167286	1.67E-74
KIRP	TF	GATC	ETV3	0.805120919	8.29E-75
KIRP	TF	GATC	ATF2	0.81115457	9.03E-77
KIRP	TF	GATC	NCOA2	0.821101553	3.63E-80
PCPG	Cell metabolism gene	GATC	LONP2	0.805290765	7.23E-44
PCPG	Cell metabolism gene	GATC	GNA11	0.806831129	3.75E-44
PCPG	Cell metabolism gene	GATC	GSR	0.810240599	8.56E-45
PCPG	Cell metabolism gene	GATC	NUP155	0.817741559	2.98E-46
PCPG	Cell metabolism gene	GATC	GLUD2	0.828004092	2.33E-48
PCPG	Cell metabolism gene	GATC	NCOA2	0.829333027	1.21E-48
PCPG	Cell metabolism gene	GATC	MGAT5	0.83827856	1.30E-50
PCPG	Cell metabolism gene	GATC	CLOCK	0.842471036	1.40E-51
PCPG	Cell metabolism gene	GATC	PAFAH1B2	0.853722458	2.56E-54
PCPG	Cell metabolism gene	GATC	PRKAR2A	0.863005934	9.35E-57
PCPG	CGC	GATC	LATS1	0.801572037	3.46E-43
PCPG	CGC	GATC	GNA11	0.806831129	3.75E-44
PCPG	CGC	GATC	TRIP11	0.809409692	1.23E-44
PCPG	CGC	GATC	BRAF	0.815826578	7.13E-46
PCPG	CGC	GATC	NCOA2	0.829333027	1.21E-48
PCPG	CGC	GATC	ASXL2	0.834046346	1.15E-49
PCPG	CGC	GATC	IL6ST	0.852223075	6.12E-54
PCPG	CGC	GATC	PAFAH1B2	0.853722458	2.56E-54
PCPG	CGC	GATC	STRN	0.860602464	4.16E-56
PCPG	Epifactor	GATC	ATF2	0.800461281	5.48E-43
PCPG	Epifactor	GATC	SMARCA5	0.810233862	8.58E-45
PCPG	Epifactor	GATC	EYA3	0.810906631	6.39E-45
PCPG	Epifactor	GATC	GTF3C4	0.813426252	2.10E-45
PCPG	Epifactor	GATC	NCOA2	0.829333027	1.21E-48
PCPG	Epifactor	GATC	ASXL2	0.834046346	1.15E-49
PCPG	Epifactor	GATC	DDX21	0.839814792	5.78E-51
PCPG	Epifactor	GATC	CLOCK	0.842471036	1.40E-51
PCPG	IUPHAR	GATC	LATS1	0.801572037	3.46E-43
PCPG	IUPHAR	GATC	CDKL5	0.803523998	1.53E-43
PCPG	IUPHAR	GATC	SLC30A4	0.804463289	1.03E-43
PCPG	IUPHAR	GATC	GSR	0.810240599	8.56E-45
PCPG	IUPHAR	GATC	SLC30A6	0.813071233	2.45E-45
PCPG	IUPHAR	GATC	GTF3C4	0.813426252	2.10E-45
PCPG	IUPHAR	GATC	IDE	0.814561802	1.26E-45
PCPG	IUPHAR	GATC	BRAF	0.815826578	7.13E-46
PCPG	IUPHAR	GATC	HIPK3	0.819952633	1.08E-46
PCPG	IUPHAR	GATC	ERN1	0.822971683	2.61E-47
PCPG	IUPHAR	GATC	SLC25A40	0.826096928	5.88E-48
PCPG	IUPHAR	GATC	SAMD8	0.829137273	1.34E-48
PCPG	IUPHAR	GATC	NCOA2	0.829333027	1.21E-48
PCPG	IUPHAR	GATC	ADAM10	0.829949299	8.95E-49
PCPG	IUPHAR	GATC	CLOCK	0.842471036	1.40E-51
PCPG	IUPHAR	GATC	DPP8	0.843529886	7.91E-52
PCPG	IUPHAR	GATC	IL6ST	0.852223075	6.12E-54
PCPG	IUPHAR	GATC	PRKAR2A	0.863005934	9.35E-57
PCPG	IUPHAR	GATC	LMTK2	0.872026173	2.66E-59
PCPG	Kinase	GATC	LATS1	0.801572037	3.46E-43
PCPG	Kinase	GATC	CDKL5	0.803523998	1.53E-43
PCPG	Kinase	GATC	BRAF	0.815826578	7.13E-46
PCPG	Kinase	GATC	HIPK3	0.819952633	1.08E-46
PCPG	Kinase	GATC	ERN1	0.822971683	2.61E-47
PCPG	Kinase	GATC	LMTK2	0.872026173	2.66E-59
PCPG	TF	GATC	ATF2	0.800461281	5.48E-43
PCPG	TF	GATC	ZNF827	0.801840956	3.09E-43
PCPG	TF	GATC	ETV3	0.815132487	9.75E-46
PCPG	TF	GATC	ZNF426	0.821524639	5.17E-47
PCPG	TF	GATC	NCOA2	0.829333027	1.21E-48
PCPG	TF	GATC	ZKSCAN1	0.83190429	3.38E-49
PCPG	TF	GATC	ZNF641	0.840372344	4.30E-51
PCPG	TF	GATC	CLOCK	0.842471036	1.40E-51
PCPG	TSG	GATC	LATS1	0.801572037	3.46E-43
THCA	Cell metabolism gene	GATC	MAN2A1	0.801729421	1.62E-129
THCA	Cell metabolism gene	GATC	MGAT5	0.804357538	5.46E-131
THCA	Cell metabolism gene	GATC	IPMK	0.804464502	4.75E-131
THCA	Cell metabolism gene	GATC	NEU3	0.816501173	4.26E-138
THCA	Cell metabolism gene	GATC	NCOA2	0.817342257	1.31E-138
THCA	Cell metabolism gene	GATC	CLOCK	0.819866541	3.68E-140
THCA	Cell metabolism gene	GATC	PAFAH1B2	0.824465148	4.73E-143
THCA	Cell metabolism gene	GATC	GNA11	0.826370015	2.83E-144
THCA	Cell metabolism gene	GATC	PRKAR2A	0.858863148	9.39E-168
THCA	CGC	GATC	STRN	0.814782532	4.64E-137
THCA	CGC	GATC	IL6ST	0.816432968	4.68E-138
THCA	CGC	GATC	NCOA2	0.817342257	1.31E-138
THCA	CGC	GATC	LATS1	0.817573951	9.46E-139
THCA	CGC	GATC	PAFAH1B2	0.824465148	4.73E-143
THCA	CGC	GATC	GNA11	0.826370015	2.83E-144
THCA	CGC	GATC	ASXL2	0.842327927	3.87E-155
THCA	Epifactor	GATC	GTF3C4	0.800534786	7.44E-129
THCA	Epifactor	GATC	RNF168	0.803066394	2.90E-130
THCA	Epifactor	GATC	EYA3	0.805061092	2.18E-131
THCA	Epifactor	GATC	DDX21	0.808060069	4.20E-133
THCA	Epifactor	GATC	ATF2	0.812799193	7.09E-136
THCA	Epifactor	GATC	PPP4R2	0.816784661	2.86E-138
THCA	Epifactor	GATC	NCOA2	0.817342257	1.31E-138
THCA	Epifactor	GATC	USP12	0.81826811	3.56E-139
THCA	Epifactor	GATC	CLOCK	0.819866541	3.68E-140
THCA	Epifactor	GATC	REST	0.822746448	5.82E-142
THCA	Epifactor	GATC	RBBP5	0.824848309	2.69E-143
THCA	Epifactor	GATC	ASXL2	0.842327927	3.87E-155
THCA	IUPHAR	GATC	TTBK2	0.800063175	1.35E-128
THCA	IUPHAR	GATC	GTF3C4	0.800534786	7.44E-129
THCA	IUPHAR	GATC	ERN1	0.80285603	3.81E-130
THCA	IUPHAR	GATC	SLK	0.803189468	2.48E-130
THCA	IUPHAR	GATC	SLC30A4	0.804123121	7.40E-131
THCA	IUPHAR	GATC	HIPK3	0.80571018	9.34E-132
THCA	IUPHAR	GATC	MAP3K2	0.81127259	5.66E-135
THCA	IUPHAR	GATC	IL6ST	0.816432968	4.68E-138
THCA	IUPHAR	GATC	NCOA2	0.817342257	1.31E-138
THCA	IUPHAR	GATC	LATS1	0.817573951	9.46E-139
THCA	IUPHAR	GATC	CLOCK	0.819866541	3.68E-140
THCA	IUPHAR	GATC	TAOK1	0.821303273	4.69E-141
THCA	IUPHAR	GATC	SLC25A40	0.826118841	4.11E-144
THCA	IUPHAR	GATC	PDPK1	0.827740118	3.66E-145
THCA	IUPHAR	GATC	DPP8	0.839115806	7.41E-153
THCA	IUPHAR	GATC	CLCN3	0.845904125	9.69E-158
THCA	IUPHAR	GATC	LMTK2	0.856607659	6.11E-166
THCA	IUPHAR	GATC	PRKAR2A	0.858863148	9.39E-168
THCA	Kinase	GATC	TTBK2	0.800063175	1.35E-128
THCA	Kinase	GATC	ERN1	0.80285603	3.81E-130
THCA	Kinase	GATC	SLK	0.803189468	2.48E-130
THCA	Kinase	GATC	HIPK3	0.80571018	9.34E-132
THCA	Kinase	GATC	MAP3K2	0.81127259	5.66E-135
THCA	Kinase	GATC	LATS1	0.817573951	9.46E-139
THCA	Kinase	GATC	TAOK1	0.821303273	4.69E-141
THCA	Kinase	GATC	PDPK1	0.827740118	3.66E-145
THCA	Kinase	GATC	LMTK2	0.856607659	6.11E-166
THCA	TF	GATC	ZBTB26	0.804353149	5.49E-131
THCA	TF	GATC	NFIC	0.806818781	2.17E-132
THCA	TF	GATC	ATF2	0.812799193	7.09E-136
THCA	TF	GATC	NCOA2	0.817342257	1.31E-138
THCA	TF	GATC	ETV3	0.818173843	4.06E-139
THCA	TF	GATC	CLOCK	0.819866541	3.68E-140
THCA	TF	GATC	REST	0.822746448	5.82E-142
THCA	TSG	GATC	LATS1	0.817573951	9.46E-139
THCA	TSG	GATC	USP12	0.81826811	3.56E-139

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KICH	GATC	NARS	1.07442061729154	0.000249803066253662
LUAD	GATC	QRSL1	-1.44147893876616	0.000391133065002894
BRCA	GATC	QARS	-4.19270554058168	0.00045278023754438
BRCA	GATC	POLG	1.31425220344681	0.000554216282437056
LUAD	GATC	NARS	-1.22666458579243	0.00134906742748461
THCA	GATC	QARS	-1.4601543520666	0.00171161769998529
LUSC	GATC	QRSL1	-1.56841516878295	0.00339826502432084
ESCA	GATC	TOP1MT	-2.34773242598418	0.0068359375
KIRP	GATC	POLG	-3.69586560276095	0.0240015927702189
HNSC	GATC	POLG	1.2995181637593	0.0331107665263062
CHOL	GATC	NARS	-7.86696864946951	0.0390625
THCA	GATC	QRSL1	-3.10847540716222	1.02220761620756e-06
KIRC	GATC	NARS	-2.40040204492647	2.49674919862186e-10
PRAD	GATC	QARS	1.84374784424986	3.33417295851411e-06
LUAD	GATC	TOP1MT	-2.29356708928726	3.8615985200212e-08
LIHC	GATC	NARS	-3.55177423456569	7.34047974405276e-07
STAD	GATC	TOP1MT	-2.15557084288535	7.71600753068924e-06
STAD	GATC	NARS2	-1.47625969382721	9.99853946268559e-05

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with GATC

PNPT1, SARS, SRSF11, KDR, Hnrnpa3, Wash, QRSL1, GATB, HIBCH, MRPL42, CYP4V2, PDPR, NARS2, D2HGDH, PUS1, POLG, FDXR, ALDH5A1, DHTKD1, NME4, THUMPD3, NIPSNAP3A, MRM1, HSPD1, PDK1, TRMT61B, APEX1, ALOX5, CTAG1B, HGS, TOMM20L, CTAG1A, IMMP2L, HSCB, ACAD9, AUH, C12orf65, C1QBP, C21orf33, C6orf203, FASTKD5, GFM1, LRPPRC, MDH2, METTL17, MRRF, MTIF2, MTIF3, PMPCA, PMPCB, SSBP1, TACO1, TBRG4, TSFM, TUFM, CLPP, S100P, SAR1B, BBS1,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
GATC	chr12	120884291	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
GATC	chr12	120884328	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
GATC	chr12	120884611	T	G	single_nucleotide_variant	Pathogenic	Combined_oxidative_phosphorylation_deficiency_42\|Cardiomyopathy,_mitochondrial	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
GATC	chr12	120894685	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GATC	chr12	120894934	C	G	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
GATC	chr12	120897559	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GATC	chr12	120897652	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GATC	chr12	120897772	T	G	single_nucleotide_variant	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant	SO:0001619\|non-coding_transcript_variant,SO:0001624\|3_prime_UTR_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
GATC	KIRP	chr12	120884511	120884511	C	T	Missense_Mutation	p.L45F	4
GATC	CESC	chr12	120884328	120884328	C	T	Silent		3
GATC	KIRC	chr12	120894973	120894974	-	C	Frame_Shift_Ins	p.P117fs	3
GATC	CESC	chr12	120894893	120894893	G	C	Missense_Mutation		2
GATC	SARC	chr12	120884322	120884331	TCTGGGCGGG	-	Frame_Shift_Del	p.PLGG13fs	2
GATC	CESC	chr12	120894916	120894916	A	G	Missense_Mutation		2
GATC	UCEC	chr12	120894897	120894897	C	T	Silent	p.S91	2
GATC	LIHC	chr12	120884359	120884359	C	T	Missense_Mutation	p.P26S	2
GATC	HNSC	chr12	120884532	120884532	G	A	Missense_Mutation	p.E52K	2
GATC	STAD	chr12	120894923	120894923	C	T	Missense_Mutation		2
GATC	STAD	chr12	120894923	120894923	C	T	Missense_Mutation	p.A100V	2
GATC	STAD	chr12	120894950	120894950	G	A	Missense_Mutation	p.R109H	2
GATC	SARC	chr12	120884352	120884352	G	A	Silent		2
GATC	THCA	chr12	120884291	120884291	C	T	Missense_Mutation		1
GATC	LGG	chr12	120894958	120894958	G	T	Nonsense_Mutation		1
GATC	SARC	chr12	120884352	120884352	G	A	Silent	p.K23K	1
GATC	THCA	chr12	120897756	120897756	C	T	Silent	p.H135H	1
GATC	LGG	chr12	120894951	120894951	C	T	Silent		1
GATC	LIHC	chr12	120884359	120884359	C	T	Missense_Mutation		1
GATC	SARC	chr12	120884319	120884319	C	G	Silent	p.A12	1
GATC	CESC	chr12	120894893	120894893	G	C	Missense_Mutation	p.R90T	1
GATC	SARC	chr12	120884322	120884331	TCTGGGCGGG	-	Frame_Shift_Del	p.L14fs	1
GATC	COAD	chr12	120884291	120884291	C	T	Missense_Mutation	p.S3L	1
GATC	LIHC	chr12	120884306	120884307	-	G	Frame_Shift_Ins	p.R8fs	1
GATC	SARC	chr12	120884352	120884352	G	A	Silent	p.K23	1
GATC	HNSC	chr12	120884532	120884532	G	A	Missense_Mutation		1
GATC	LUAD	chr12	120884581	120884581	G	T	Missense_Mutation	p.R68L	1
GATC	SKCM	chr12	120884561	120884561	C	T	Silent	p.I61I	1
GATC	OV	chr12	119368865	119368865	C	T	Missense_Mutation	p.A35V	1
GATC	BLCA	chr12	120894928	120894928	G	A	Missense_Mutation		1
GATC	PRAD	chr12	120897761	120897761	G	C	Nonstop_Mutation	p.*137S	1
GATC	BLCA	chr12	120884567	120884567	C	T	Silent		1
GATC	SARC	chr12	120884322	120884331	TCTGGGCGGG	-	Frame_Shift_Del		1
GATC	BLCA	chr12	120894928	120894928	G	A	Missense_Mutation	p.E102K	1
GATC	KIRP	chr12	120884511	120884511	C	T	Missense_Mutation		1
GATC	SARC	chr12	120884319	120884319	C	G	Silent		1
GATC	BLCA	chr12	120884567	120884567	C	T	Silent	p.F63F	1
GATC	THCA	chr12	120897756	120897756	C	T	Silent		1
GATC	LGG	chr12	120894951	120894951	C	T	Silent	p.R109R	1

Copy number variation (CNV) of GATC
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across GATC
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
94173	UCEC	TCGA-A5-A2K2	GATC	chr12	120894982	+	CCDC64	chr12	120499513	+
94173	UCEC	TCGA-A5-A2K2-01A	GATC	chr12	120894982	+	CCDC64	chr12	120499514	+
103111	Non-Cancer	TCGA-EL-A3ZL-11A	GATC	chr12	120884632	+	COX6A1	chr12	120876181	+
71320	STAD	TCGA-D7-A4Z0-01A	GATC	chr12	120884632	+	GCN1L1	chr12	120565778	-
101268	N/A	BI494736	GATC	chr12	120901550	+	MYT1L	chr2	1991109	-
91183	LUAD	TCGA-69-8253-01A	GATC	chr12	120898961	+	SFTPB	chr2	85885668	-
91183	LUAD	TCGA-69-8253-01A	GATC	chr12	120898970	+	SFTPB	chr2	85885659	-
85655	N/A	BI494483	GATC	chr12	120901552	+	SPDYA	chr2	29047240	+
86654	UCEC	TCGA-A5-A2K2-01A	PXN	chr12	120703420	-	GATC	chr12	120894879	+
86656	OV	TCGA-25-1324-01A	SRSF9	chr12	120900036	-	GATC	chr12	120899192	+
86656	STAD	TCGA-L5-A8NH-01A8	SRSF9	chr12	120899830	-	GATC	chr12	120899371	+
86656	STAD	TCGA-L5-A8NH-01A8	SRSF9	chr12	120900796	-	GATC	chr12	120899205	+
86656	STAD	TCGA-R6-A8WC-01A6	SRSF9	chr12	120899973	-	GATC	chr12	120899075	+
86656	STAD	TCGA-R6-A8WC-01A6	SRSF9	chr12	120900849	-	GATC	chr12	120899194	+
86656	N/A	BG750277	SRSF9	chr12	120907225	-	GATC	chr12	120899968	+
86656	N/A	CF139973	SRSF9	chr12	120899474	-	GATC	chr12	120899713	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
SARC	GATC	0.00942009079960508	0.26
LUAD	GATC	0.0122824233986079	0.33
KIRP	GATC	0.0204771752843331	0.53
COAD	GATC	0.0224030430637235	0.56

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
THCA	GATC	0.0436016246155548	1
UVM	GATC	0.0367345413673106	1
UCS	GATC	0.0463123814132182	1

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source