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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: MKNK2 (NCBI Gene ID:2872)

Gene Summary

Gene Summary

Gene Information	Gene Name: MKNK2
	Gene ID: 2872
	Gene Symbol	MKNK2
	Gene ID	2872
	Gene Name	MAPK interacting serine/threonine kinase 2
	Synonyms	GPRK7\|MNK2
	Cytomap	19p13.3
	Type of Gene	protein-coding
	Description	MAP kinase-interacting serine/threonine-protein kinase 2G protein-coupled receptor kinase 7MAP kinase interacting serine/threonine kinase 2MAP kinase signal-integrating kinase 2MAPK signal-integrating kinase 2
	Modification date	20200313
	UniProtAcc	Q9HBH9

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MKNK2	GO:0006468	protein phosphorylation	11463832
Hgene	MKNK2	GO:0030097	hemopoiesis	21149447
Hgene	MKNK2	GO:0035556	intracellular signal transduction	11463832
Hgene	MKNK2	GO:0071243	cellular response to arsenic-containing substance	18299328

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
MKNK2	(67.6 - 355.7]

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Translation Studies in PubMed

We searched PubMed using 'MKNK2[title] AND translation [title] AND human.'

Gene	Title	PMID
MKNK2	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000250896	2041838	2042033	In-frame
ENST00000591601	2041838	2042033	In-frame
ENST00000250896	2046184	2046282	Frame-shift
ENST00000591601	2046184	2046282	Frame-shift
ENST00000250896	2046602	2046690	Frame-shift
ENST00000591601	2046602	2046690	Frame-shift

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000591601	2041838	2042033	3593	787	981	465	250	315
ENST00000250896	2041838	2042033	3791	996	1190	465	250	315

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
Q9HBH9	250	315	1	465	Chain	ID=PRO_0000086336;Note=MAP kinase-interacting serine/threonine-protein kinase 2
Q9HBH9	250	315	1	465	Chain	ID=PRO_0000086336;Note=MAP kinase-interacting serine/threonine-protein kinase 2
Q9HBH9	250	315	84	388	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9HBH9	250	315	84	388	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9HBH9	250	315	299	299	Metal binding	Note=Zinc;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:16216586,ECO:0000269\|PubMed:16917500;Dbxref=PMID:16216586,PMID:16917500
Q9HBH9	250	315	299	299	Metal binding	Note=Zinc;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:16216586,ECO:0000269\|PubMed:16917500;Dbxref=PMID:16216586,PMID:16917500
Q9HBH9	250	315	311	311	Metal binding	Note=Zinc;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:16216586,ECO:0000269\|PubMed:16917500;Dbxref=PMID:16216586,PMID:16917500
Q9HBH9	250	315	311	311	Metal binding	Note=Zinc;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:16216586,ECO:0000269\|PubMed:16917500;Dbxref=PMID:16216586,PMID:16917500
Q9HBH9	250	315	314	314	Metal binding	Note=Zinc;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:16216586,ECO:0000269\|PubMed:16917500;Dbxref=PMID:16216586,PMID:16917500
Q9HBH9	250	315	314	314	Metal binding	Note=Zinc;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:16216586,ECO:0000269\|PubMed:16917500;Dbxref=PMID:16216586,PMID:16917500
Q9HBH9	250	315	261	261	Sequence conflict	Note=V->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9HBH9	250	315	261	261	Sequence conflict	Note=V->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9HBH9	250	315	254	256	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2AC3
Q9HBH9	250	315	254	256	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2AC3
Q9HBH9	250	315	259	264	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2AC3
Q9HBH9	250	315	259	264	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2AC3
Q9HBH9	250	315	267	272	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2AC3
Q9HBH9	250	315	267	272	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2AC3
Q9HBH9	250	315	273	275	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2AC3
Q9HBH9	250	315	273	275	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2AC3
Q9HBH9	250	315	276	290	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2AC3
Q9HBH9	250	315	276	290	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2AC3
Q9HBH9	250	315	312	324	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2AC3
Q9HBH9	250	315	312	324	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2AC3

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
LUSC	MKNK2	-1.00435001691645	0.00471185133936548
ESCA	MKNK2	-2.10810888803662	0.0068359375
HNSC	MKNK2	-1.43064910062775	1.00401621239144e-07
LUAD	MKNK2	-3.27370421058807	1.05528520885174e-08
COAD	MKNK2	-2.35247669824009	1.59740447998047e-05
STAD	MKNK2	-1.43850603759457	6.68526627123356e-05

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
GBM	MKNK2	hsa-miR-6766-3p	85	1	0.0166666666666667
OV	MKNK2	hsa-miR-125b-5p	72	-0.447622300008537	0.000983975674341324
UCEC	MKNK2	hsa-miR-125a-5p	64	-0.394652406417112	0.0215963403964006
UCEC	MKNK2	hsa-miR-125b-5p	72	-0.380595874713522	0.0270830484891797

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
SKCM	MKNK2	3	2	0.0248849255485273	0.662332159624413	0.389517343485618	0.301695883455292	0.451261937648395

Translation factor expression regulation through copy number variation of Translation factor

Cancer type

Gene

Coefficient

Pvalue

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with MKNK2 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
KICH	Cell metabolism gene	MKNK2	INPPL1	0.801885516	1.29E-21
KICH	Cell metabolism gene	MKNK2	PYGB	0.832758781	1.41E-24
KICH	CGC	MKNK2	POLG	0.818840392	3.59E-23
KICH	IUPHAR	MKNK2	INPPL1	0.801885516	1.29E-21
KICH	IUPHAR	MKNK2	STK35	0.821352061	2.04E-23
KICH	Kinase	MKNK2	STK35	0.821352061	2.04E-23

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
LUSC	MKNK2	MKNK1	-1.7724058315911	0.000119179323433261
COAD	MKNK2	EIF4E2	-1.6767866186069	0.000144809484481812
LUAD	MKNK2	MKNK1	-1.64881335054025	0.000184346986492713
BRCA	MKNK2	EIF4E2	-1.81299600715269	0.000370278590179521
STAD	MKNK2	ATP7A	-3.27464799491988	0.000657554250210524
LUSC	MKNK2	ATP7A	-1.33000555127291	0.000679097693381554
LUAD	MKNK2	EIF4E2	-1.75169025615215	0.000823732994424591
KICH	MKNK2	MAPK1	1.27319002595358	0.000911891460418701
BRCA	MKNK2	MAPK3	-1.61909976139263	0.00193136402459222
CHOL	MKNK2	ATP7A	-1.94531270875576	0.00390625
CHOL	MKNK2	MAPK3	-1.54068193424676	0.00390625
KIRP	MKNK2	MKNK1	-1.83550648151309	0.00608485564589501
KICH	MKNK2	EIF4G1	-1.46656081150743	0.00612920522689819
HNSC	MKNK2	ATP7A	-3.96693658731539	0.00965754519575058
ESCA	MKNK2	MAPK1	-1.17755474324053	0.0185546875
BRCA	MKNK2	MAPK1	-1.67954875219151	0.0427276834041307
KICH	MKNK2	ATP7A	2.04280252549023	1.0073184967041e-05
KIRC	MKNK2	EIF4E2	-4.19473040895577	1.04336657477644e-05
BRCA	MKNK2	MAPK14	-1.6928131480761	1.08867679255958e-06
PRAD	MKNK2	MAPK14	1.20273850965986	2.06740855708439e-05
KIRC	MKNK2	ATF4	-2.05004013451381	2.37769366427877e-11
KIRC	MKNK2	MKNK1	-1.36155431828684	4.53899662243056e-11
COAD	MKNK2	MAPK3	-1.17173283146352	5.66244125366212e-07
KICH	MKNK2	EIF4E	1.61675210562671	6.55651092529297e-06

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with MKNK2

EIF4G1, MAPK1, ESR2, MAPK14, RPL7A, ELAVL1, RBX1, VHL, CUL2, VBP1, MAPK8, CSTF2, MIF, RBM4, VCL, BAG6, SYMPK, KHSRP, NOLC1, WDR46, USP15, TRAP1, CELF1, NUDT21, WWP2, EXOC3, RAB11FIP2, PLXNA3, HAUS7, ADCK1, RBM26, BHLHE41, ZCCHC6, ZMYM1, CD99L2, MRRF, TICAM1, RICTOR, TRIM25, CUL4B, MESDC2, PSMA1, DDX58,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
MKNK2	chr19	2042040	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene

Cancer type

Chromosome

Start

End

RefSeeq

MutSeq

Mutation type

AAchange

# samples

Copy number variation (CNV) of MKNK2
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across MKNK2
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
77950	Non-Cancer	ERR188200	BTBD2	chr19	2013546	-	MKNK2	chr19	2043581	-
77950	Non-Cancer	ERR188200	BTBD2	chr19	2015296	-	MKNK2	chr19	2043581	-
77950	N/A	BM145378	CACNA2D3	chr3	54576003	+	MKNK2	chr19	2037470	+
77950	ESCA	TCGA-L5-A891	ELL	chr19	18569014	-	MKNK2	chr19	2046690	-
77950	ESCA	TCGA-L5-A891	ELL	chr19	18569015	-	MKNK2	chr19	2046690	-
77950	Non-Cancer	ERR315460	HEATR1	chr1	236713872	-	MKNK2	chr19	2037806	-
77950	N/A	BE720244	KCNK1	chr1	233802576	+	MKNK2	chr19	2046405	+
102739	OV	TCGA-09-1666	MKNK2	chr19	2050799	-	AP3D1	chr19	2102267	-
102739	OV	TCGA-09-1666-01A	MKNK2	chr19	2050800	-	AP3D1	chr19	2102267	-
78778	STAD	TCGA-BR-A4IY-01A	MKNK2	chr19	2037605	-	CNDP2	chr18	72180929	+
100130	N/A	BQ027252	MKNK2	chr19	2037658	+	CRK	chr17	1335764	+
86725	BRCA	TCGA-EW-A1PA-01A	MKNK2	chr19	2046185	-	FAM151A	chr1	55076228	-
77950	N/A	BU674802	MKNK2	chr19	2037548	+	MKNK2	chr19	2037605	-
101825	N/A	AI096463	MKNK2	chr19	2037862	+	ORC3	chr6	88306179	-
54111	N/A	BM148315	MKNK2	chr19	2037659	+	PANK4	chr1	2439977	+
81649	LAML	TCGA-AB-2897-03A	MKNK2	chr19	2041839	-	RNF126	chr19	652884	-
89828	N/A	BF765876	MKNK2	chr19	2038867	+	TOR1AIP2	chr1	179846934	-
98677	N/A	BM765288	MKNK2	chr19	2038030	-	UBAC2	chr13	100037910	+
102392	ESCA	TCGA-L5-A8NR	MKNK2	chr19	2050799	-	WIZ	chr19	15538344	-
100444	BRCA	TCGA-BH-A1FD-01A	MKNK2	chr19	2046366	-	ZFR2	chr19	3852612	-
77950	Non-Cancer	ERR315404	OAZ1	chr19	2269743	+	MKNK2	chr19	2043581	-
77951	N/A	BQ351516	RPS4Y1	chrY	2733263	+	MKNK2	chr19	2037878	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
SARC	MKNK2	0.0110322777542027	0.31
BLCA	MKNK2	0.0116132016229315	0.31
READ	MKNK2	0.0183777549138365	0.48
LIHC	MKNK2	0.0421897392659084	1

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
GBM	MKNK2	0.0171176601652299	0.53
LAML	MKNK2	0.0468833752476663	1
OV	MKNK2	0.00425661809340315	0.14
SARC	MKNK2	0.0114521140530583	0.37

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source