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Center for Computational Systems Medicine
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Gene Summary

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Translation studies in PubMed

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Exon Skipping Events

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Expression

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Expression Regulation

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Associated Genes

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Protein 3D Structure

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Protein-Protein Interaction

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Mutations

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Prognostic Analysis

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Gender Association

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Age Association

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Related Drugs

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Related Diseases

Translation Factor: MRPS18B (NCBI Gene ID:28973)


Gene Summary

check button Gene Summary
Gene InformationGene Name: MRPS18B
Gene ID: 28973
Gene Symbol

MRPS18B

Gene ID

28973

Gene Namemitochondrial ribosomal protein S18B
SynonymsC6orf14|HSPC183|HumanS18a|MRP-S18-2|MRPS18-2|PTD017|S18amt
Cytomap

6p21.33

Type of Geneprotein-coding
Description28S ribosomal protein S18b, mitochondrial28S ribosomal protein S18-2, mitochondrialMRP-S18-bS18mt-bmitochondrial ribosomal protein S18-2mitochondrial small ribosomal subunit protein bS18bmitochondrial small ribosomal subunit protein bS18m-Bmitochon
Modification date20200320
UniProtAcc

Q9Y676


check button Child GO biological process term(s) under GO:0006412
GO IDGO term
GO:0032543Mitochondrial translation
GO:0005840Ribosome
GO:0006412Translation


check button Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Inferred gene age of translation factor.
GeneInferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
MRPS18B(733 - 1119.25]


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Translation Studies in PubMed

check button We searched PubMed using 'MRPS18B[title] AND translation [title] AND human.'
GeneTitlePMID
MRPS18B..


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Exon Skipping Events

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.
all structure

check button Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ENSTExon skip start (DNA)Exon Skip end (DNA)ORF

check button Exon skipping position in the amino acid sequence.
ENSTExon skip start (DNA)Exon Skip end (DNA)Len(transcript seq)Exon skip start (mRNA)Exon Skip end (mRNA)Len(amino acid seq)Exon skip start (AA)Exon Skip end (AA)

check button Potentially (partially) lost protein functional features of UniProt.
UniProtAccExon skip start (AA)Exon Skip end (AA)Function feature start (AA)Function feature end (AA)Functional feature typeFunctional feature desc.


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Expression


check buttonGene expression level across TCGA pancancer
all structure

check buttonGene expression level across GTEx pantissue
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check buttonExpression level of gene isoforms across TCGA pancancer
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check buttonExpression level of gene isoforms across GTEx pantissue
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check buttonCancer(tissue) type-specific expression level of Translation factor using z-score distriution
all structure

check buttonDifferential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)
all structure
Cancer typeTranslation factorFCadj.pval
KIRCMRPS18B-1.089993480106740.00208385211535325
CHOLMRPS18B-1.343419614730830.0078125
BLCAMRPS18B-2.793162037050830.0180816650390625
LUADMRPS18B-2.591326042841760.0228310323601027
STADMRPS18B-2.187838450614950.0341199110262096


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Expression Regulation


check buttonTranslation factor expression regulation through miRNA binding
Cancer typeGenemiRNATargetScan binding score (Context++ score percentile)CoefficientPvalue


check buttonTranslation factor expression regulation through methylation in the promoter of Translation factor
all structure
Cancer typeGenemethyl group bmethyl group aDEG pvalavg methyl in bavg methyl in aavg exp in bavg exp in a

check buttonTranslation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)
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Cancer typeGenemethyl group bmethyl group aDEG pvalavg methyl in bavg methyl in aavg exp in bavg exp in a

check buttonTranslation factor expression regulation through copy number variation of Translation factor
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Cancer typeGeneCoefficientPvalue

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Associated Genes


check button Strongly correlated genes belong to cellular important gene groups with MRPS18B (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)
all structure
Cancer typeGene groupTranslation factorCorrelated geneCoefficientPvalue
DLBCCell metabolism geneMRPS18BEXOSC50.8081088973.82E-12
DLBCCell metabolism geneMRPS18BMDH20.8288546783.49E-13
DLBCCell metabolism geneMRPS18BGSTZ10.8337015741.91E-13
DLBCEpifactorMRPS18BEXOSC50.8081088973.82E-12
DLBCTFMRPS18BZNF6530.8177945381.30E-12
KICHCell metabolism geneMRPS18BMLX0.8396018032.58E-25
KICHTFMRPS18BMLX0.8396018032.58E-25
KICHTSGMRPS18BAPITD10.8195388183.07E-23
UVMCell metabolism geneMRPS18BLSM20.81307215.19E-20
UVMCell metabolism geneMRPS18BPPP2R5D0.8491072472.53E-23
UVMIUPHARMRPS18BTUBB0.8128180495.44E-20
UVMIUPHARMRPS18BCSNK2B0.8147146223.80E-20
UVMTFMRPS18BZBTB90.8533981238.94E-24


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Protein structure


check button Protein 3D structure
Visit iCn3D.


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Protein-Protein Interaction


check button Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))
all structure

check buttonOverlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))
all structure
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* Edge colors based on TCGA cancer types.

check button* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))
all structure
Cancer typeTranslation factorInteracting protein coding geneFCadj.pval
BRCAMRPS18BMRPS27-2.13313928627760.000127527962379903
BRCAMRPS18BMRPS33-2.503674235762720.000154377851145473
LIHCMRPS18BMRPS31-1.075652322561630.000180054839259286
LUADMRPS18BMRPS18A-1.541238640420490.000452706327224566
LIHCMRPS18BMRPS71.270293954772080.00182077236082954
LUADMRPS18BMRPS311.581409157004420.00351308111790755
KICHMRPS18BMRPS21.265439895550150.0114533305168152
PRADMRPS18BMRPS18A-1.892511955532890.0168224419088856
KICHMRPS18BMRPS31-1.441716135774950.0173123478889465
ESCAMRPS18BMRPS2-3.205567880846750.0244140625
COADMRPS18BMRPS311.259306100836780.0253507494926453
BLCAMRPS18BMRPS31-1.749897165816380.0445594787597656
KICHMRPS18BMRPS221.593457798849860.0451226830482483
THCAMRPS18BMRPS101.334136917649911.55171507174296e-05
LUSCMRPS18BMRPS18A-4.261818030181251.79996309233889e-05
LUSCMRPS18BMRPS2-2.709308464885081.92864354932136e-09
LUADMRPS18BMRPS27-2.464611208735992.13247131179291e-05
LUADMRPS18BMRPL42-6.346102496024912.48255276366547e-08
LIHCMRPS18BMRPS2-1.147710553588284.2584580238307e-05
KIRCMRPS18BMRPL42-4.3820953362485.26630854166927e-06
LUSCMRPS18BMRPS33-3.327026699718655.71093314566242e-07
HNSCMRPS18BMRPS18A-2.45201201684755.97184352955084e-05
PRADMRPS18BMRPS311.428780089783386.76861513404814e-05
THCAMRPS18BMRPS31-1.557598099332116.91106419786075e-09
KIRCMRPS18BMRPS31-4.325410042408659.31897250092369e-08
BRCAMRPS18BMRPS7-2.127874602704349.33194208595055e-10


check button Protein-protein interactors with this translation factor (BIOGRID-3.4.160)
PPI interactors with MRPS18B
EWSR1, NFKBIL1, UBC, ICT1, Ybx1, CUL3, CAND1, MRPS22, MRPS25, MRPS9, MRPS26, MRPS35, MRPS28, HNRNPAB, KARS, QARS, FUS, UBR5, MYH9, EBNA3B, RB1, pth4, EXOSC6, PARK2, CEP250, NEDD1, TP53, TUBGCP3, TUBGCP4, VCP, MOV10, TRA2A, TRMT10B, MRPS31, HNRNPA1, DAP3, MRPS2, PTCD3, MRPS6, ENTHD2, Pabpc1, Prkci, Wdr5, Ksr1, ERBB3, MRPS34, MRPS11, MRPS27, AURKAIP1, RBM3, DLD, PARK7, RNF157, EIF3H, GTPBP4, MRPS18B, PYHIN1, EFTUD2, HEXIM1, MEPCE, LARP7, RECQL4, MB21D1, BET1, FBL, RPS6, MRM1, HSPD1, PDK1, TRMT61B, RC3H1, RC3H2, PPP1CC, ALYREF, SNRNP70, Dppa3, DUSP14, ITFG1, HMGB1, TRIM28, SQSTM1, TMED8, CD81, IGFBP5, TMEM128, MIP, CLEC1A, ZFPL1, BMP10, SLC35A1, TNFRSF10C, TUSC5, TMEM120B, LRP10, SYS1, LAT, SEC22B, CUL7, PLEKHA4, ENG, HIST1H2BD, ESR1, ERCC6, CELF1, ELAVL1, GRSF1, ZC3HAV1, IGF2BP1, IGF2BP2, XRN2, KIF20A, DEPDC1B, ACAD9, AUH, C12orf65, C17orf80, C1QBP, C21orf33, C6orf203, C8orf82, MCUR1, CCDC90B, CHCHD1, COX15, CRYZ, CS, DDX28, DHX30, EXD2, FASTKD2, FASTKD3, FASTKD5, GFM1, GFM2, HINT2, LONP1, LRPPRC, MCU, CCDC109B, MDH2, METTL15, METTL17, MRPL11, MRPS12, MRRF, MTERF3, MTFMT, MTG1, MTG2, MTIF2, MTIF3, MTRF1, MTRF1L, NGRN, OTC, PMPCA, PMPCB, RMND1, RPUSD3, RPUSD4, SLIRP, SSBP1, SURF1, TACO1, TBRG4, TEFM, TFAM, C19orf52, TMEM70, TRUB2, TSFM, TUFM, VWA8, MAFB, NINL, RBM39, DNAJC21, DNAJA3, DNAJC15, DNAJC19, DNAJC28, DNAJC30, DNAJC4, HSCB, PHB2, Rnf2, TULP3, DDRGK1, COX4I1, PDHA1, NBR1, FZR1, MAP4K3, ZBTB2, IGF2BP3, MRPS10, MRPS24, PTCD1, GLI4, MCAT, SRP14, E4F1, ABT1, MRPS33, YBX1, RPS9, MRPS7, MRPS21, FAM120A, SRSF5, ZNF460, ZNF17, MRPS23, HNRNPU, MRPS17, SRSF3, POLG, KIAA0391, MRPS15, MRPS5, H1FNT, ZNF133, DDX55, SUPV3L1, MRPS16, RPL17, ZNF263, LEPREL2, TOP3A, RBMS2, FGF13, NOA1, NDUFAF7, STRBP, CBX6, YBX2, MRPS18C, MRPS14, ZBTB48, LIN28A, RPL10, PRR3, PCK1, GAPDHS, HIST1H2AM, ZNF770, ERAL1, NEIL1, SRSF7, ZC3H3, SIRT3, BHLHA15, RPL35, KLF5, KLF8, SOX15, SOX2, TLX2, TLX3, KLF12, KLF15, KLF16, KLF4, TLX1,


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Mutations


check button Clinically associated variants from ClinVar.
GeneChrPositionRefSeqVarSeqRefSeeqVarTypePathogenicDiseaseVarInfo


check button nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.
all structure


check button SNVs and Indels
GeneCancer typeChromosomeStartEndRefSeeqMutSeqMutation typeAAchange# samples
MRPS18BESCAchr63059331530593315GTMissense_Mutationp.R173L5
MRPS18BBRCAchr63058756330587563CTMissense_Mutationp.R89W3
MRPS18BUCECchr63058775830587758GCMissense_Mutationp.D116H3
MRPS18BPRADchr63059348430593484CTSilentp.G229G3
MRPS18BLIHCchr63058770730587707A-Frame_Shift_Delp.K99fs2
MRPS18BSTADchr63058735630587356CASilent2
MRPS18BSTADchr63058735630587356CASilentp.P55P2
MRPS18BBRCAchr63058756830587568TASilentp.T902
MRPS18BSTADchr63058752330587523TCSilentp.A75A2
MRPS18BBRCAchr63058773330587733CTSilentp.I1072
MRPS18BLUADchr63059348330593483GTMissense_Mutationp.G229V2
MRPS18BCESCchr63058727830587278CGSilent2
MRPS18BKIRCchr63059343530593435TCMissense_Mutationp.L213P2
MRPS18BCESCchr63058571530585715GAMissense_Mutation2
MRPS18BCESCchr63059338630593386GCMissense_Mutation2
MRPS18BUCECchr63058731630587316CAMissense_Mutationp.S42Y2
MRPS18BCESCchr63058727830587278CGSilentp.L291
MRPS18BBLCAchr63059344130593441GAMissense_Mutationp.R215H1
MRPS18BSKCMchr63059062030590620CTSilentp.L122L1
MRPS18BCESCchr63059338630593386GCMissense_Mutationp.D197H1
MRPS18BLIHCchr63058736030587360A-Frame_Shift_Delp.K57fs1
MRPS18BBLCAchr63058736930587369GAMissense_Mutationp.E60K1
MRPS18BCOADchr63059331430593314CTMissense_Mutationp.R173W1
MRPS18BLIHCchr63058771630587716G-Frame_Shift_Delp.G102fs1
MRPS18BBLCAchr63059065930590659CGMissense_Mutationp.F135L1
MRPS18BESCAchr63058567930585679CGMissense_Mutationp.L13V1
MRPS18BLIHCchr63059355630593556C-Frame_Shift_Delp.G253fs1
MRPS18BLUADchr63058565730585657AGSilentp.V5V1
MRPS18BSTADchr63058771030587712GTT-In_Frame_Delp.99_100del1
MRPS18BHNSCchr63058564730585647CTMissense_Mutation1
MRPS18BSTADchr63059065630590656CASilentp.I134I1
MRPS18BHNSCchr63058564730585647CTMissense_Mutationp.A2V1
MRPS18BLUADchr63058758530587585TGSplice_Site1
MRPS18BSTADchr63058771030587712GTT-In_Frame_Delp.V101del1
MRPS18BBLCAchr63058571330585713GAMissense_Mutation1
MRPS18BLUADchr63058751430587514CTSilentp.P72P1
MRPS18BLGGchr63058728630587287TT-Frame_Shift_Delp.L32fs1
MRPS18BBLCAchr63059344130593441GAMissense_Mutation1
MRPS18BLUSCchr63059354730593547GASilentp.G250G1
MRPS18BLIHCchr63058727530587275CTSilentp.P28P1
MRPS18BBLCAchr63058736930587369GAMissense_Mutation1
MRPS18BOVchr63059064830590648GTMissense_Mutationp.G132C1
MRPS18BCESCchr63058571530585715GAMissense_Mutationp.V25I1
MRPS18BLIHCchr63058736030587360A-Frame_Shift_Delp.W56X1
MRPS18BBLCAchr63059065930590659CGMissense_Mutation1

check buttonCopy number variation (CNV) of MRPS18B
* Click on the image to open the original image in a new window.
all structure

check buttonFusion gene breakpoints (product of the structural variants (SVs)) across MRPS18B
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


check button Fusion genes with this translation factor from FusionGDB2.0.
FusionGDB2 IDDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
92974BRCATCGA-A8-A092-01ADDR1chr630859965+MRPS18Bchr630587270+
92974BLCATCGA-K4-A3WVGMDSchr61726649-MRPS18Bchr630590608+
92974BLCATCGA-K4-A3WV-01AGMDSchr61726650-MRPS18Bchr630590609+
92974BLCATCGA-K4-A3WV-01AGMDSchr61726650-MRPS18Bchr630592660+
92974BLCATCGA-K4-A3WV-01AGMDSchr61726650-MRPS18Bchr6_dbb_hap31884247+
92974BLCATCGA-K4-A3WV-01AGMDSchr61726650-MRPS18Bchr6_ssto_hap71922888+
100213N/AAI420562MRPS18Bchr630593886-EIF3Achr10120808602+
90020N/ABP432280MRPS18Bchr630587766+MAN1A1chr6119505243+
96599N/AAI655595MRPS18Bchr630594057-NFATC2IPchr1628975450+
99377STADTCGA-HU-A4HD-01AMRPS18Bchr630587766+PPP1R10chr630586405-
92974N/AEC547104RTN3chr1163455931-MRPS18Bchr630593593+
92974N/AAW269879TMEM176Bchr7150488514+MRPS18Bchr630594032+
92975PRADTCGA-2A-A8W1TOB2chr2241842382-MRPS18Bchr630592659+
92975PRADTCGA-2A-A8W1-01ATOB2chr2241840115-MRPS18Bchr630592659+
92975PRADTCGA-2A-A8W1-01ATOB2chr2241842378-MRPS18Bchr630592659+
92975PRADTCGA-2A-A8W1-01ATOB2chr2241842383-MRPS18Bchr630592660+


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Prognostic Analysis


check button Kaplan-Meier plots with logrank tests of overall survival (OS)
all structure
Cancer typeTranslation factorCoefficentHazard ratioWald test pvalLikelihool ratio pvalLogrank test pval# samples


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Translation factor and Gender


check button Differential gene expression between female and male. (Wilcoxon test, pval<0.05)
all structure
Cancer typeTranslation factorpvaladj.p
KIRPMRPS18B0.001420308421487910.04
HNSCMRPS18B0.01486750073600110.4
LIHCMRPS18B0.02610857205427250.68

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Translation factor and Age


check button Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)
all structure
Cancer typeTranslation factorpvaladj.p
LIHCMRPS18B0.00235871448300930.075
THCAMRPS18B0.0001534229464821470.0051
BRCAMRPS18B0.03376306833622351
UVMMRPS18B0.006292988683902060.2
UCECMRPS18B0.04125956038738961

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Related Drugs


check button Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)
UniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases


check button Diseases associated with this translation factor.
(DisGeNet 4.0)
Disease IDDisease Name# PubMedsDisease source
C0024623Malignant neoplasm of stomach1CTD_human
C1708349Hereditary Diffuse Gastric Cancer1CTD_human