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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: GRM5 (NCBI Gene ID:2915)

Gene Summary

Gene Summary

Gene Information	Gene Name: GRM5
	Gene ID: 2915
	Gene Symbol	GRM5
	Gene ID	2915
	Gene Name	glutamate metabotropic receptor 5
	Synonyms	GPRC1E\|MGLUR5\|PPP1R86\|mGlu5
	Cytomap	11q14.2-q14.3
	Type of Gene	protein-coding
	Description	metabotropic glutamate receptor 5glutamate receptor, metabotropic 5protein phosphatase 1, regulatory subunit 86
	Modification date	20200329
	UniProtAcc	P41594

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0006414	Translational elongation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene

Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25

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Translation Studies in PubMed

We searched PubMed using 'GRM5[title] AND translation [title] AND human.'

Gene	Title	PMID
GRM5	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000305447	88258476	88258572	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000305447	88258476	88258572	4588	2781	2876	1212	877	908

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
P41594	877	908	21	1212	Chain	ID=PRO_0000012932;Note=Metabotropic glutamate receptor 5
P41594	877	908	821	1212	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:25042998;Dbxref=PMID:25042998
P41594	877	908	877	908	Alternative sequence	ID=VSP_002030;Note=In isoform 1. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:7908515;Dbxref=PMID:7908515
P41594	877	908	896	1165	Alternative sequence	ID=VSP_047710;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.3

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
KIRP	GRM5	1.02815103076215	0.0111397774890065
THCA	GRM5	-1.65104554430915	2.53556205720315e-08

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
CHOL	GRM5	hsa-miR-30a-5p	85	-0.329235396484415	0.0272161958933755
CHOL	GRM5	hsa-miR-30d-5p	85	-0.335452376651055	0.0242797586018197
UVM	GRM5	hsa-miR-30d-5p	85	0.408562518985333	0.000185469423418463

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
PAAD	GRM5	3	2	0.0179723398353835	0.662207291666667	0.472935	-0.0983610575988453	0.00946019240115439

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
THCA	GRM5	0.025355785	0.024056144
ESCA	GRM5	0.008500782	0.04653305

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with GRM5 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	IUPHAR	GRM5	CTSC	0.831499829	1.52E-12
DLBC	IUPHAR	GRM5	SLC17A6	0.811167161	2.74E-12
LGG	CGC	GRM5	RGS7	0.82344908	4.72E-132
LGG	IUPHAR	GRM5	RGS7	0.82344908	4.72E-132
UVM	Cell metabolism gene	GRM5	PDE6C	0.800268115	5.30E-19
UVM	Cell metabolism gene	GRM5	PDE6H	0.806589531	1.72E-19
UVM	Cell metabolism gene	GRM5	GNG13	0.810094654	9.05E-20
UVM	Cell metabolism gene	GRM5	KCNC2	0.818343707	1.89E-20
UVM	Cell metabolism gene	GRM5	ST8SIA3	0.819864439	1.41E-20
UVM	Cell metabolism gene	GRM5	ISL1	0.857218425	3.45E-24
UVM	Cell metabolism gene	GRM5	DDC	0.860366112	1.54E-24
UVM	CGC	GRM5	CNTNAP2	0.818783324	1.74E-20
UVM	CGC	GRM5	CSMD3	0.854669605	6.53E-24
UVM	Epifactor	GRM5	PRMT8	0.846969766	4.20E-23
UVM	Epifactor	GRM5	ACTL6B	0.863042274	7.62E-25
UVM	IUPHAR	GRM5	PDE6C	0.800268115	5.30E-19
UVM	IUPHAR	GRM5	KCNJ16	0.802461665	3.60E-19
UVM	IUPHAR	GRM5	ESRRB	0.802611345	3.51E-19
UVM	IUPHAR	GRM5	KCNA1	0.803650452	2.91E-19
UVM	IUPHAR	GRM5	GRIA4	0.804795143	2.38E-19
UVM	IUPHAR	GRM5	SLC17A6	0.805474899	2.10E-19
UVM	IUPHAR	GRM5	PDE6H	0.806589531	1.72E-19
UVM	IUPHAR	GRM5	GPR179	0.807500489	1.46E-19
UVM	IUPHAR	GRM5	GRIN1	0.809009901	1.10E-19
UVM	IUPHAR	GRM5	CNGB1	0.81273246	5.53E-20
UVM	IUPHAR	GRM5	KCNH6	0.814102208	4.27E-20
UVM	IUPHAR	GRM5	SCN1A	0.817176305	2.37E-20
UVM	IUPHAR	GRM5	KCNC2	0.818343707	1.89E-20
UVM	IUPHAR	GRM5	GRK1	0.819649239	1.47E-20
UVM	IUPHAR	GRM5	TRPC7	0.823544303	6.77E-21
UVM	IUPHAR	GRM5	GABRA2	0.825902838	4.20E-21
UVM	IUPHAR	GRM5	SLC8A3	0.825932943	4.18E-21
UVM	IUPHAR	GRM5	CNGA3	0.826423403	3.78E-21
UVM	IUPHAR	GRM5	GRIK1	0.828150065	2.65E-21
UVM	IUPHAR	GRM5	GRM7	0.828357153	2.54E-21
UVM	IUPHAR	GRM5	SLC7A14	0.834165794	7.45E-22
UVM	IUPHAR	GRM5	GPR12	0.836177633	4.82E-22
UVM	IUPHAR	GRM5	GJA10	0.842091462	1.29E-22
UVM	IUPHAR	GRM5	SLC32A1	0.842093799	1.29E-22
UVM	IUPHAR	GRM5	CHRM2	0.845853177	5.45E-23
UVM	IUPHAR	GRM5	PRMT8	0.846969766	4.20E-23
UVM	IUPHAR	GRM5	KCNB2	0.847938051	3.34E-23
UVM	IUPHAR	GRM5	GLRA1	0.850652343	1.75E-23
UVM	IUPHAR	GRM5	GRID2	0.852857861	1.02E-23
UVM	IUPHAR	GRM5	GABRG2	0.856278424	4.37E-24
UVM	IUPHAR	GRM5	KCNA4	0.858657597	2.39E-24
UVM	IUPHAR	GRM5	HTR5A	0.860073278	1.66E-24
UVM	IUPHAR	GRM5	DDC	0.860366112	1.54E-24
UVM	IUPHAR	GRM5	DRD1	0.86127374	1.21E-24
UVM	IUPHAR	GRM5	GABRG1	0.861874313	1.04E-24
UVM	IUPHAR	GRM5	GRIA2	0.8619517	1.02E-24
UVM	IUPHAR	GRM5	SCN2A	0.862606264	8.56E-25
UVM	IUPHAR	GRM5	GRIA3	0.863315303	7.09E-25
UVM	IUPHAR	GRM5	GABRA1	0.867237949	2.46E-25
UVM	IUPHAR	GRM5	KCNJ9	0.8691399	1.46E-25
UVM	IUPHAR	GRM5	KCNG4	0.872711515	5.31E-26
UVM	IUPHAR	GRM5	GABRR3	0.874719766	2.97E-26
UVM	IUPHAR	GRM5	SLC17A8	0.876353849	1.84E-26
UVM	IUPHAR	GRM5	RGS8	0.877346361	1.37E-26
UVM	IUPHAR	GRM5	SLC4A10	0.888469173	4.18E-28
UVM	Kinase	GRM5	GRK1	0.819649239	1.47E-20
UVM	TF	GRM5	ESRRB	0.802611345	3.51E-19
UVM	TF	GRM5	NEUROD4	0.8037956	2.84E-19
UVM	TF	GRM5	SCRT2	0.804387002	2.56E-19
UVM	TF	GRM5	BHLHE23	0.808864634	1.13E-19
UVM	TF	GRM5	NEUROD1	0.819131447	1.62E-20
UVM	TF	GRM5	TFAP2B	0.819979814	1.37E-20
UVM	TF	GRM5	FEZF2	0.833085334	9.39E-22
UVM	TF	GRM5	LHX3	0.844370173	7.68E-23
UVM	TF	GRM5	ISL1	0.857218425	3.45E-24
UVM	TF	GRM5	ST18	0.863407637	6.92E-25
UVM	TF	GRM5	NEUROG1	0.86463421	4.99E-25
UVM	TF	GRM5	MYT1L	0.878280416	1.04E-26
UVM	TSG	GRM5	ESRRB	0.802611345	3.51E-19
UVM	TSG	GRM5	CNTNAP2	0.818783324	1.74E-20

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
BRCA	GRM5	SHANK1	-1.41613598821954	0.000130105765210244
PRAD	GRM5	HOMER1	-1.32416171629391	0.000403113349114023
LUSC	GRM5	HOMER2	2.89215520538463	0.000552086454522047
STAD	GRM5	ESR1	1.30910781013895	0.000980085227638483
LUSC	GRM5	PRNP	1.38631059034879	0.00155860218028531
STAD	GRM5	GNAQ	-1.7182645709596	0.00166679499670863
ESCA	GRM5	ESR1	1.72956558278024	0.0029296875
ESCA	GRM5	GNAQ	-1.30042285116727	0.0048828125
COAD	GRM5	DLG4	1.09493696624995	0.012952595949173
BLCA	GRM5	HOMER2	-2.3554701769558	0.014068603515625
KIRP	GRM5	HOMER1	-1.30765361822675	0.0148032568395138
UCEC	GRM5	HOMER2	2.82058723883396	0.015625
READ	GRM5	AQP4	1.73505256762916	0.03125
LUAD	GRM5	GRM1	2.17888851748763	0.035889573917085
CHOL	GRM5	HOMER1	-1.44048529349013	0.0390625
HNSC	GRM5	GNAQ	1.39363399916288	0.0448960527075997
UCEC	GRM5	DLG4	-3.32382974727639	0.046875
BRCA	GRM5	GNAQ	-1.42809180012775	1.24221841523555e-11
KIRC	GRM5	HOMER2	3.09951112948455	1.55738143877187e-11
KIRC	GRM5	AQP4	-1.69227285231197	1.878054794032e-05
LIHC	GRM5	PRNP	2.39304282016208	1.95973184466089e-07
HNSC	GRM5	PRNP	1.41881900945864	2.30083969654516e-08
LUAD	GRM5	HOMER1	-1.52997256338984	2.50960797565542e-06
KIRC	GRM5	ESR1	-3.33122650532863	2.72286325678163e-08
LIHC	GRM5	ESR1	-5.5493944971495	3.0830663046718e-09
KICH	GRM5	DLG4	3.55424390455388	3.19480895996094e-05
LUAD	GRM5	AQP4	-1.05373298698322	3.79251210274868e-11
LUAD	GRM5	GNAQ	-3.47177253915815	4.43580332236554e-11
THCA	GRM5	AQP4	-1.23964251491824	5.51584862383177e-09
LUSC	GRM5	AQP4	-2.29757269023598	5.62667765456517e-10
PRAD	GRM5	AQP4	1.32525786217407	6.68841890472086e-06
HNSC	GRM5	SHANK1	-2.83042121097191	6.75183794101032e-05

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with GRM5

SIAH1, CALM1, PRKCA, HOMER1, CEP104, EVC2, PRKCD, PRKCZ, ADORA2A, ACTN1, PRNP, GOPC, RGS4, NCDN, FRMPD4, GRASP, CDK5, APP, GRIN1, GRIN2A,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
GRM5	chr11	88241963	C	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
GRM5	chr11	88242027	C	G	single_nucleotide_variant	Benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
GRM5	chr11	88242045	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
GRM5	chr11	88242066	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant	SO:0001619\|non-coding_transcript_variant,SO:0001819\|synonymous_variant
GRM5	chr11	88242153	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
GRM5	chr11	88242199	C	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
GRM5	chr11	88242249	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
GRM5	chr11	88242271	T	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
GRM5	chr11	88242429	G	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
GRM5	chr11	88242441	G	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
GRM5	chr11	88242467	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
GRM5	chr11	88242468	C	A	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
GRM5	chr11	88242606	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
GRM5	chr11	88242621	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
GRM5	chr11	88242624	C	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
GRM5	chr11	88300241	G	T	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
GRM5	chr11	88300277	T	A	single_nucleotide_variant	Uncertain_significance	not_specified	SO:0001583\|missense_variant	SO:0001583\|missense_variant
GRM5	chr11	88300346	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
GRM5	chr11	88300391	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
GRM5	chr11	88300436	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
GRM5	chr11	88300511	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
GRM5	chr11	88300631	A	C	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
GRM5	chr11	88300724	A	T	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
GRM5	chr11	88300805	G	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
GRM5	chr11	88300817	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
GRM5	chr11	88300963	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
GRM5	chr11	88301164	C	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GRM5	chr11	88323773	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
GRM5	chr11	88330418	T	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
GRM5	chr11	88337876	AAC	A	Microsatellite	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GRM5	chr11	88337922	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
GRM5	chr11	88338014	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
GRM5	chr11	88338074	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
GRM5	chr11	88338092	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
GRM5	chr11	88372707	GCCATTTTCCCATACATCATCATATGTAAGCCTCATGATAATCTGCAAGTTCATTTTTTTTTTTTTTGAGATGGAGTCTCGCACTGTCACCCAGGCTGGAGTGCAGTGGCACAATCTCTCCTCACTGCAAGCTCCACCTCCCAGGTTCATGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGTGCCTGCCACCACGCCCAGCTAATTTTTTGTATTCTTCAACAAGCTTATCAGGTCTCAATTT	G	Deletion	not_provided	Normal_pregnancy	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GRM5	chr11	88386361	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
GRM5	chr11	88386578	G	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
GRM5	chr11	88583139	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
GRM5	chr11	88583188	C	G	single_nucleotide_variant	not_provided	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
GRM5	chr11	88780384	T	G	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
GRM5	chr11	88780432	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
GRM5	chr11	88780518	T	C	single_nucleotide_variant	association	Autism_spectrum_disorder	SO:0001583\|missense_variant	SO:0001583\|missense_variant
GRM5	chr11	88780852	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
GRM5	chr11	88780954	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
GRM5	chr11	88780957	C	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
GRM5	LUAD	chr11	88337916	88337916	A	G	Missense_Mutation	p.L455P	7
GRM5	LUAD	chr11	88780774	88780774	G	T	Silent	p.I89I	6
GRM5	SKCM	chr11	88780987	88780987	C	T	Silent	p.G18G	5
GRM5	LUSC	chr11	88300351	88300351	G	A	Missense_Mutation	p.R834C	5
GRM5	STAD	chr11	88583111	88583111	G	A	Missense_Mutation	p.R292C	4
GRM5	BRCA	chr11	88780577	88780577	G	A	Missense_Mutation	p.A155V	4
GRM5	UCEC	chr11	88301131	88301131	G	A	Nonsense_Mutation	p.R574*	4
GRM5	STAD	chr11	88258487	88258487	T	G	Missense_Mutation	p.T906P	4
GRM5	SKCM	chr11	88300558	88300558	G	A	Missense_Mutation	p.P765S	3
GRM5	ESCA	chr11	88337964	88337964	T	C	Missense_Mutation	p.E439G	3
GRM5	ACC	chr11	88386562	88386562	C	G	Missense_Mutation	p.W307C	3
GRM5	LUAD	chr11	88780796	88780796	T	C	Missense_Mutation	p.D82G	3
GRM5	BLCA	chr11	88337977	88337977	G	A	Missense_Mutation	p.R435W	3
GRM5	SKCM	chr11	88583166	88583166	C	T	Silent	p.V273V	3
GRM5	ESCA	chr11	88583156	88583156	A	C	Missense_Mutation	p.F277V	3
GRM5	HNSC	chr11	88583210	88583210	T	C	Missense_Mutation	p.K259E	3
GRM5	LUAD	chr11	88300971	88300971	A	T	Missense_Mutation	p.L627Q	3
GRM5	PRAD	chr11	88780467	88780467	C	A	Missense_Mutation	p.V192L	3
GRM5	SKCM	chr11	88780705	88780705	G	A	Silent	p.F112F	3
GRM5	LUAD	chr11	88338066	88338066	T	C	Missense_Mutation	p.Y405C	3
GRM5	LUAD	chr11	88300512	88300512	G	A	Missense_Mutation	p.T780M	3
GRM5	PAAD	chr11	88386453	88386453	G	A	Missense_Mutation	p.L344F	3
GRM5	PAAD	chr11	88780583	88780583	G	T	Missense_Mutation	p.S153Y	3
GRM5	CHOL	chr11	88323786	88323786	G	C	Missense_Mutation		3
GRM5	PAAD	chr11	88242512	88242512	C	T	Missense_Mutation	p.A963T	3
GRM5	UCEC	chr11	88780442	88780442	C	A	Missense_Mutation	p.R200M	3
GRM5	PAAD	chr11	88300355	88300355	G	A	Silent	p.N832N	3
GRM5	UCEC	chr11	88780913	88780913	A	G	Missense_Mutation	p.V43A	3
GRM5	UCS	chr11	88386450	88386450	G	A	Missense_Mutation	p.R345W	3
GRM5	CHOL	chr11	88323786	88323786	G	C	Missense_Mutation	p.P558R	3
GRM5	PAAD	chr11	88301064	88301064	A	G	Missense_Mutation	p.F596S	3
GRM5	UCEC	chr11	88781038	88781038	C	G	Missense_Mutation	p.M1I	3
GRM5	HNSC	chr11	88583097	88583097	C	A	Silent		3
GRM5	PAAD	chr11	88300442	88300442	A	C	Missense_Mutation	p.C803W	3
GRM5	SKCM	chr11	88258513	88258513	C	T	Missense_Mutation	p.G897E	3
GRM5	ESCA	chr11	88242134	88242134	C	T	Missense_Mutation	p.V1089I	3
GRM5	ACC	chr11	88242036	88242036	G	A	Silent	p.I1121I	2
GRM5	PAAD	chr11	88300355	88300355	G	A	Silent		2
GRM5	SKCM	chr11	88301112	88301112	G	A	Missense_Mutation	p.P580L	2
GRM5	SKCM	chr11	88241775	88241775	G	A	Silent	p.S1208S	2
GRM5	STAD	chr11	88337911	88337911	C	T	Missense_Mutation	p.D457N	2
GRM5	STAD	chr11	88781002	88781002	T	C	Silent	p.K13K	2
GRM5	UCEC	chr11	88301141	88301141	T	C	Silent	p.V570	2
GRM5	TGCT	chr11	88338026	88338026	G	A	Silent	p.L418L	2
GRM5	UCEC	chr11	88780513	88780513	G	T	Missense_Mutation	p.S176R	2
GRM5	BLCA	chr11	88780576	88780576	G	T	Silent	p.A155A	2
GRM5	HNSC	chr11	88386464	88386464	T	C	Missense_Mutation	p.Y340C	2
GRM5	HNSC	chr11	88386529	88386529	C	A	Missense_Mutation	p.Q318H	2
GRM5	STAD	chr11	88780736	88780736	G	A	Missense_Mutation	p.S102L	2
GRM5	LUAD	chr11	88583117	88583117	T	C	Missense_Mutation	p.M290V	2
GRM5	CESC	chr11	88780671	88780671	C	T	Missense_Mutation		2
GRM5	UCEC	chr11	88330482	88330482	T	C	Missense_Mutation	p.Y478C	2
GRM5	PAAD	chr11	88300442	88300442	A	C	Missense_Mutation		2
GRM5	SKCM	chr11	88781001	88781001	C	T	Missense_Mutation	p.E14K	2
GRM5	KIRP	chr11	88242044	88242044	G	A	Missense_Mutation	p.P1119S	2
GRM5	SKCM	chr11	88300912	88300912	G	A	Nonsense_Mutation	p.Q647*	2
GRM5	STAD	chr11	88386441	88386441	T	G	Missense_Mutation	p.T348P	2
GRM5	STAD	chr11	88386483	88386483	C	T	Missense_Mutation	p.V334I	2
GRM5	THYM	chr11	88301075	88301075	C	T	Silent		2
GRM5	UCEC	chr11	88780534	88780534	C	A	Missense_Mutation	p.Q169H	2
GRM5	PRAD	chr11	88583140	88583140	G	A	Missense_Mutation	p.T282M	2
GRM5	HNSC	chr11	88300894	88300894	G	C	Missense_Mutation	p.L653V	2
GRM5	SARC	chr11	88300954	88300954	A	C	Missense_Mutation		2
GRM5	SKCM	chr11	88780804	88780804	G	A	Silent	p.I79I	2
GRM5	LIHC	chr11	88583097	88583097	C	T	Silent	p.A296A	2
GRM5	LUAD	chr11	88780748	88780748	G	T	Missense_Mutation	p.S98Y	2
GRM5	UCEC	chr11	88242657	88242657	G	A	Silent	p.S914	2
GRM5	CESC	chr11	88300848	88300848	C	T	Missense_Mutation		2
GRM5	UCEC	chr11	88337960	88337960	G	T	Silent	p.S440	2
GRM5	BLCA	chr11	88583193	88583193	G	A	Silent	p.L264L	2
GRM5	SKCM	chr11	88583119	88583119	G	A	Missense_Mutation	p.A289V	2
GRM5	LGG	chr11	88780946	88780946	G	A	Missense_Mutation	p.P32L	2
GRM5	STAD	chr11	88338063	88338063	G	A	Missense_Mutation	p.S406L	2
GRM5	UCEC	chr11	88780544	88780544	T	C	Missense_Mutation	p.N166S	2
GRM5	ESCA	chr11	88300621	88300621	G	T	Missense_Mutation	p.L744I	2
GRM5	LIHC	chr11	88338049	88338049	G	T	Missense_Mutation	p.L411I	2
GRM5	STAD	chr11	88583181	88583181	C	A	Missense_Mutation	p.L268F	2
GRM5	STAD	chr11	88780628	88780628	C	T	Missense_Mutation	p.R138H	2
GRM5	UCEC	chr11	88258556	88258556	G	A	Silent	p.L883	2
GRM5	LUAD	chr11	88386449	88386449	C	T	Missense_Mutation	p.R345Q	2
GRM5	UCEC	chr11	88338068	88338068	G	T	Silent	p.I404	2
GRM5	PAAD	chr11	88386453	88386453	G	A	Missense_Mutation		2
GRM5	STAD	chr11	88780446	88780446	C	A	Missense_Mutation	p.A199S	2
GRM5	UCEC	chr11	88780715	88780715	C	T	Missense_Mutation	p.S109N	2
GRM5	ESCA	chr11	88300675	88300675	T	A	Missense_Mutation	p.I726F	2
GRM5	SARC	chr11	88780694	88780694	G	A	Missense_Mutation		2
GRM5	STAD	chr11	88323855	88323855	G	A	Missense_Mutation	p.T535I	2
GRM5	STAD	chr11	88386447	88386447	G	A	Missense_Mutation	p.P346S	2
GRM5	UCEC	chr11	88300439	88300439	G	T	Missense_Mutation	p.F804L	2
GRM5	CESC	chr11	88300278	88300278	C	G	Missense_Mutation		2
GRM5	UCEC	chr11	88338129	88338129	G	T	Missense_Mutation	p.S384Y	2
GRM5	SKCM	chr11	88386377	88386377	C	T	Missense_Mutation	p.G369E	2
GRM5	LUAD	chr11	88330421	88330421	T	C	Silent	p.E498E	2
GRM5	UCEC	chr11	88780778	88780778	T	C	Missense_Mutation	p.N88S	2
GRM5	ESCA	chr11	88583156	88583156	A	C	Missense_Mutation		2
GRM5	KIRC	chr11	88300984	88300984	C	A	Missense_Mutation	p.A623S	2
GRM5	STAD	chr11	88258490	88258490	C	G	Missense_Mutation	p.A905P	2
GRM5	STAD	chr11	88300299	88300299	T	G	Missense_Mutation	p.K851T	2
GRM5	LUAD	chr11	88338052	88338052	C	A	Missense_Mutation	p.G410W	2
GRM5	UCEC	chr11	88300757	88300757	G	T	Missense_Mutation	p.F698L	2
GRM5	LUAD	chr11	88300589	88300589	G	T	Nonsense_Mutation	p.C754*	2
GRM5	UCEC	chr11	88386410	88386410	A	C	Missense_Mutation	p.F358C	2
GRM5	BLCA	chr11	88301116	88301116	C	T	Missense_Mutation	p.E579K	2
GRM5	SKCM	chr11	88780869	88780869	C	T	Missense_Mutation	p.G58R	2
GRM5	COAD	chr11	88780430	88780430	T	C	Missense_Mutation	p.D204G	2
GRM5	SKCM	chr11	88323880	88323880	C	T	Missense_Mutation	p.E527K	2
GRM5	STAD	chr11	88300371	88300371	G	T	Missense_Mutation	p.A827D	2
GRM5	UCEC	chr11	88780838	88780838	C	A	Missense_Mutation	p.R68I	2
GRM5	SARC	chr11	88780694	88780694	G	A	Missense_Mutation	p.S116F	2
GRM5	STAD	chr11	88780945	88780945	C	T	Silent	p.P32P	2
GRM5	LUAD	chr11	88337921	88337921	C	A	Silent	p.T453T	2
GRM5	UCEC	chr11	88300781	88300781	G	T	Silent	p.A690	2
GRM5	BLCA	chr11	88386506	88386506	G	C	Missense_Mutation	p.T326R	2
GRM5	LUAD	chr11	88780709	88780709	T	A	Missense_Mutation	p.E111V	2
GRM5	LUAD	chr11	88300451	88300451	G	T	Silent	p.I800I	2
GRM5	UCEC	chr11	88386432	88386432	G	A	Nonsense_Mutation	p.R351*	2
GRM5	BLCA	chr11	88583124	88583124	C	T	Silent	p.L287L	2
GRM5	SKCM	chr11	88300258	88300258	G	A	Silent	p.L865L	2
GRM5	SKCM	chr11	88780633	88780633	G	A	Silent	p.S136S	2
GRM5	STAD	chr11	88780446	88780446	C	A	Missense_Mutation		2
GRM5	LIHC	chr11	88338049	88338049	G	T	Missense_Mutation		2
GRM5	STAD	chr11	88301037	88301037	C	T	Missense_Mutation	p.R605H	2
GRM5	UCEC	chr11	88781019	88781019	A	G	Missense_Mutation	p.S8P	2
GRM5	SARC	chr11	88300954	88300954	A	C	Missense_Mutation	p.F633V	2
GRM5	STAD	chr11	88300530	88300530	A	T	Missense_Mutation	p.I774N	2
GRM5	STAD	chr11	88300827	88300827	C	A	Missense_Mutation	p.G675V	2
GRM5	LUAD	chr11	88300288	88300288	C	T	Missense_Mutation	p.A855T	2
GRM5	UCEC	chr11	88300813	88300815	TCT	-	In_Frame_Del	p.K679in_frame_del	2
GRM5	LUAD	chr11	88323889	88323889	G	T	Silent	p.R524R	2
GRM5	UCEC	chr11	88583092	88583092	T	G	Missense_Mutation	p.E298A	2
GRM5	SKCM	chr11	88780397	88780397	G	A	Missense_Mutation	p.S215L	2
GRM5	SKCM	chr11	88300543	88300543	C	T	Missense_Mutation	p.E770K	2
GRM5	STAD	chr11	88338063	88338063	G	A	Missense_Mutation		2
GRM5	HNSC	chr11	88781022	88781022	G	A	Silent	p.L7L	2
GRM5	LIHC	chr11	88330465	88330465	C	T	Missense_Mutation		2
GRM5	STAD	chr11	88338027	88338027	A	G	Missense_Mutation	p.L418P	2
GRM5	BLCA	chr11	88780659	88780659	G	A	Missense_Mutation		2
GRM5	BRCA	chr11	88583174	88583174	C	T	Missense_Mutation	p.A271T	2
GRM5	READ	chr11	88300672	88300672	G	A	Nonsense_Mutation	p.R727X	2
GRM5	CESC	chr11	88386447	88386447	G	T	Missense_Mutation	p.P346T	2
GRM5	KIRC	chr11	88780709	88780709	T	G	Missense_Mutation	p.E111A	2
GRM5	LIHC	chr11	88241851	88241851	G	-	Frame_Shift_Del	p.P1183fs	2
GRM5	STAD	chr11	88242557	88242557	C	T	Missense_Mutation	p.V948I	2
GRM5	LUAD	chr11	88386426	88386426	G	T	Missense_Mutation	p.P353T	2
GRM5	STAD	chr11	88780392	88780392	C	T	Missense_Mutation	p.V217M	2
GRM5	UCEC	chr11	88301097	88301097	A	G	Missense_Mutation	p.V585A	2
GRM5	UCEC	chr11	88742212	88742212	G	T	Missense_Mutation	p.S239Y	2
GRM5	SKCM	chr11	88300437	88300437	G	A	Missense_Mutation	p.S805L	2
GRM5	SKCM	chr11	88323882	88323882	C	T	Missense_Mutation	p.G526E	2
GRM5	STAD	chr11	88386483	88386483	C	T	Missense_Mutation		2
GRM5	LIHC	chr11	88742219	88742219	T	A	Missense_Mutation		2
GRM5	BLCA	chr11	88780766	88780766	C	T	Missense_Mutation	p.G92D	2
GRM5	KIRC	chr11	88330476	88330476	T	G	Missense_Mutation	p.D480A	2
GRM5	LIHC	chr11	88242621	88242621	C	-	Frame_Shift_Del	p.G926fs	2
GRM5	STAD	chr11	88241767	88241767	G	A	Missense_Mutation	p.S1211L	2
GRM5	STAD	chr11	88780735	88780735	C	T	Silent	p.S102S	2
GRM5	LUAD	chr11	88300349	88300349	G	T	Silent	p.R834R	2
GRM5	LUAD	chr11	88780521	88780521	C	T	Missense_Mutation	p.A174T	2
GRM5	UCEC	chr11	88780437	88780437	T	C	Missense_Mutation	p.M202V	2
GRM5	BLCA	chr11	88241803	88241803	G	A	Missense_Mutation	p.T1199I	2
GRM5	HNSC	chr11	88386464	88386464	T	C	Missense_Mutation		2
GRM5	SKCM	chr11	88781023	88781023	G	A	Silent	p.I6I	2
GRM5	LGG	chr11	88780946	88780946	G	A	Missense_Mutation		2
GRM5	STAD	chr11	88300345	88300345	C	T	Missense_Mutation		2
GRM5	HNSC	chr11	88780752	88780752	C	T	Missense_Mutation	p.D97N	2
GRM5	LIHC	chr11	88330465	88330465	C	T	Missense_Mutation	p.V484I	2
GRM5	STAD	chr11	88780590	88780590	A	G	Missense_Mutation	p.S151P	2
GRM5	STAD	chr11	88780385	88780385	G	A	Missense_Mutation	p.T219I	2
GRM5	LUAD	chr11	88780897	88780897	A	C	Silent	p.T48T	2
GRM5	UCEC	chr11	88301134	88301134	G	T	Missense_Mutation	p.L573I	2
GRM5	LUAD	chr11	88330451	88330451	G	C	Missense_Mutation	p.D488E	2
GRM5	TGCT	chr11	88338026	88338026	G	A	Silent		2
GRM5	UCEC	chr11	88780469	88780469	A	G	Missense_Mutation	p.V191A	2
GRM5	BLCA	chr11	88323888	88323888	C	T	Missense_Mutation	p.R524Q	2
GRM5	STAD	chr11	88300345	88300345	C	T	Missense_Mutation	p.A836T	2
GRM5	LIHC	chr11	88241917	88241917	A	T	Missense_Mutation	p.V1161E	2
GRM5	STAD	chr11	88780887	88780887	C	T	Missense_Mutation	p.V52I	2
GRM5	LUAD	chr11	88780894	88780894	C	G	Silent	p.V49V	2
GRM5	CESC	chr11	88386447	88386447	G	T	Missense_Mutation		2
GRM5	SARC	chr11	88300371	88300371	G	T	Missense_Mutation		2
GRM5	BLCA	chr11	88300776	88300776	G	A	Missense_Mutation	p.A692V	1
GRM5	COAD	chr11	88323884	88323884	C	A	Missense_Mutation	p.K525N	1
GRM5	HNSC	chr11	88780943	88780943	C	A	Missense_Mutation		1
GRM5	KIRP	chr11	88300498	88300498	A	T	Missense_Mutation	p.W785R	1
GRM5	LIHC	chr11	88780483	88780483	T	-	Frame_Shift_Del	p.K186fs	1
GRM5	LUAD	chr11	88300969	88300969	C	A	Missense_Mutation	p.G628C	1
GRM5	LUAD	chr11	88241831	88241831	A	T	Missense_Mutation	p.C1190S	1
GRM5	LUAD	chr11	88301038	88301038	G	T	Missense_Mutation	p.R605S	1
GRM5	BLCA	chr11	88583193	88583193	G	A	Silent		1
GRM5	PCPG	chr11	88241981	88241981	C	T	Missense_Mutation	p.A1140T	1
GRM5	SKCM	chr11	88300718	88300718	G	A	Silent	p.L711L	1
GRM5	LGG	chr11	88242657	88242657	G	A	Silent		1
GRM5	STAD	chr11	88300595	88300596	-	A	Frame_Shift_Ins	p.L752fs	1
GRM5	COAD	chr11	88242118	88242118	C	A	Missense_Mutation	p.C1062F	1
GRM5	GBM	chr11	88780659	88780659	G	A	Missense_Mutation	p.R128C	1
GRM5	HNSC	chr11	88258477	88258477	C	A	Splice_Site	p.S909_splice	1
GRM5	SKCM	chr11	88323792	88323792	G	A	Missense_Mutation	p.S556F	1
GRM5	LIHC	chr11	88780420	88780420	C	A	Missense_Mutation	p.K207N	1
GRM5	UCEC	chr11	88300813	88300815	TCT	-	In_Frame_Del	p.K679del	1
GRM5	LUSC	chr11	88780767	88780767	C	A	Missense_Mutation	p.G92C	1
GRM5	BLCA	chr11	88300391	88300391	C	T	Silent		1
GRM5	LUSC	chr11	88338018	88338018	C	A	Missense_Mutation	p.G421V	1
GRM5	SARC	chr11	88337989	88337989	G	T	Missense_Mutation		1
GRM5	BLCA	chr11	88337912	88337912	G	A	Silent	p.F456F	1
GRM5	COAD	chr11	88330490	88330490	T	C	Silent	p.G475G	1
GRM5	HNSC	chr11	88386432	88386432	G	T	Silent		1
GRM5	LIHC	chr11	88241871	88241871	C	-	Frame_Shift_Del	p.G1176fs	1
GRM5	STAD	chr11	88300437	88300437	G	T	Nonsense_Mutation	p.S805X	1
GRM5	LUAD	chr11	88300621	88300621	G	C	Missense_Mutation	p.L744V	1
GRM5	LGG	chr11	88300406	88300406	G	T	Silent		1
GRM5	LUAD	chr11	88780700	88780700	C	A	Missense_Mutation	p.R114I	1
GRM5	LUAD	chr11	88300586	88300586	G	A	Silent	p.T755T	1
GRM5	BLCA	chr11	88301116	88301116	C	T	Missense_Mutation		1
GRM5	SKCM	chr11	88780812	88780812	C	T	Missense_Mutation	p.E77K	1
GRM5	LUSC	chr11	88300875	88300875	T	-	Frame_Shift_Del	p.Y659fs	1
GRM5	COAD	chr11	88242129	88242129	G	A	Silent	p.G1058G	1
GRM5	GBM	chr11	88338071	88338071	G	A	Silent		1
GRM5	STAD	chr11	88242192	88242192	C	T	Silent	p.T1069T	1
GRM5	LUSC	chr11	88780992	88780992	G	A	Missense_Mutation	p.R17C	1
GRM5	BLCA	chr11	88300723	88300723	C	A	Missense_Mutation		1
GRM5	STAD	chr11	88242070	88242070	G	A	Missense_Mutation	p.T1110M	1
GRM5	LUAD	chr11	88583183	88583183	A	T	Missense_Mutation	p.L268M	1
GRM5	ACC	chr11	88242036	88242036	G	A	Silent	p.I1089I	1
GRM5	PAAD	chr11	88301064	88301064	A	G	Missense_Mutation		1
GRM5	COAD	chr11	88337911	88337911	C	A	Missense_Mutation	p.D457Y	1
GRM5	HNSC	chr11	88583210	88583210	T	C	Missense_Mutation		1
GRM5	SKCM	chr11	88300511	88300511	C	T	Silent	p.T780T	1
GRM5	LIHC	chr11	88330435	88330435	T	-	Frame_Shift_Del	p.M494fs	1
GRM5	HNSC	chr11	88780494	88780494	T	C	Missense_Mutation	p.T183A	1
GRM5	SKCM	chr11	88330446	88330446	C	T	Missense_Mutation	p.G490E	1
GRM5	LGG	chr11	88323889	88323889	G	A	Nonsense_Mutation		1
GRM5	LUAD	chr11	88323836	88323836	C	A	Missense_Mutation	p.E541D	1
GRM5	THYM	chr11	88780441	88780441	C	T	Silent	p.R200R	1
GRM5	LUAD	chr11	88338109	88338109	G	T	Missense_Mutation	p.H391N	1
GRM5	BLCA	chr11	88583124	88583124	C	T	Silent		1
GRM5	BLCA	chr11	88780504	88780504	C	G	Silent	p.L179L	1
GRM5	MESO	chr11	88300544	88300544	G	A	Silent		1
GRM5	SARC	chr11	88330491	88330491	C	T	Missense_Mutation		1
GRM5	COAD	chr11	88242532	88242532	G	A	Missense_Mutation	p.T924M	1
GRM5	HNSC	chr11	88300894	88300894	G	C	Missense_Mutation		1
GRM5	HNSC	chr11	88258477	88258477	C	A	Missense_Mutation	p.S909I	1
GRM5	SKCM	chr11	88780813	88780813	C	T	Silent	p.L76L	1
GRM5	LUAD	chr11	88583080	88583080	A	G	Missense_Mutation	p.L302P	1
GRM5	LUSC	chr11	88780993	88780993	G	T	Silent	p.V16V	1
GRM5	BLCA	chr11	88300897	88300897	C	A	Missense_Mutation		1
GRM5	CESC	chr11	88241884	88241884	G	A	Missense_Mutation		1
GRM5	STAD	chr11	88780527	88780527	A	G	Missense_Mutation	p.Y172H	1
GRM5	LUAD	chr11	88780591	88780591	G	A	Silent	p.G150G	1
GRM5	BLCA	chr11	88780486	88780486	G	T	Missense_Mutation		1
GRM5	BLCA	chr11	88717888	88717888	G	T	Missense_Mutation	p.R294S	1
GRM5	COAD	chr11	88386386	88386386	C	T	Missense_Mutation	p.R366Q	1
GRM5	HNSC	chr11	88330368	88330368	T	C	Missense_Mutation		1
GRM5	LGG	chr11	88386475	88386475	C	G	Missense_Mutation	p.W336C	1
GRM5	SKCM	chr11	88242144	88242144	G	-	Frame_Shift_Del	p.P1085fs	1
GRM5	LIHC	chr11	88386381	88386381	C	-	Frame_Shift_Del	p.E368fs	1
GRM5	HNSC	chr11	88323788	88323788	C	A	Missense_Mutation	p.W557C	1
GRM5	SKCM	chr11	88300274	88300274	G	A	Silent	p.S859S	1
GRM5	LGG	chr11	88338068	88338068	G	T	Silent		1
GRM5	LUAD	chr11	88301113	88301113	G	T	Missense_Mutation	p.P580T	1
GRM5	THYM	chr11	88337977	88337977	G	T	Silent	p.R435R	1
GRM5	LUAD	chr11	88300320	88300320	C	A	Missense_Mutation	p.R844L	1
GRM5	BLCA	chr11	88242642	88242642	C	G	Missense_Mutation		1
GRM5	BLCA	chr11	88258484	88258484	T	C	Missense_Mutation	p.M907V	1
GRM5	PRAD	chr11	88300528	88300528	C	T	Missense_Mutation	p.A775T	1
GRM5	CESC	chr11	88780671	88780671	C	T	Missense_Mutation	p.E124K	1
GRM5	MESO	chr11	88330390	88330390	A	G	Missense_Mutation		1
GRM5	COAD	chr11	88242621	88242621	C	-	Frame_Shift_Del	p.Q927fs	1
GRM5	HNSC	chr11	88781022	88781022	G	A	Silent		1
GRM5	HNSC	chr11	88386571	88386571	A	T	Missense_Mutation	p.S304R	1
GRM5	SKCM	chr11	88300709	88300709	C	T	Missense_Mutation	p.M714I	1
GRM5	LIHC	chr11	88386445	88386445	T	C	Silent	p.P346P	1
GRM5	LUAD	chr11	88583213	88583213	C	T	Missense_Mutation	p.D258N	1
GRM5	BLCA	chr11	88780572	88780572	G	A	Nonsense_Mutation	p.Q157*	1
GRM5	STAD	chr11	88300672	88300672	G	A	Nonsense_Mutation	p.R727*	1
GRM5	BLCA	chr11	88386506	88386506	G	C	Missense_Mutation		1
GRM5	BLCA	chr11	88583170	88583170	C	T	Missense_Mutation	p.R272Q	1
GRM5	PAAD	chr11	88780583	88780583	G	T	Missense_Mutation		1
GRM5	COAD	chr11	88386487	88386487	G	T	Silent	p.P332P	1
GRM5	HNSC	chr11	88300970	88300970	C	A	Silent		1
GRM5	SKCM	chr11	88241888	88241888	C	T	Missense_Mutation	p.D1139N	1
GRM5	LGG	chr11	88242605	88242605	G	A	Missense_Mutation	p.R932C	1
GRM5	STAD	chr11	88300595	88300596	-	-	Frame_Shift_Ins		1
GRM5	HNSC	chr11	88338041	88338041	G	A	Silent	p.N413N	1
GRM5	SKCM	chr11	88780589	88780589	G	A	Missense_Mutation	p.S151F	1
GRM5	LGG	chr11	88386475	88386475	C	G	Missense_Mutation		1
GRM5	STAD	chr11	88781018	88781018	G	C	Nonsense_Mutation	p.S8X	1
GRM5	LUAD	chr11	88717902	88717902	A	G	Missense_Mutation	p.I289T	1
GRM5	THYM	chr11	88780549	88780549	A	G	Silent	p.L164L	1
GRM5	LUAD	chr11	88258517	88258518	-	G	Frame_Shift_Ins	p.P895fs	1
GRM5	BLCA	chr11	88241803	88241803	G	A	Missense_Mutation		1
GRM5	BLCA	chr11	88300391	88300391	C	T	Silent	p.P820P	1
GRM5	PRAD	chr11	88300321	88300321	G	A	Missense_Mutation	p.R844C	1
GRM5	CESC	chr11	88300278	88300278	C	G	Missense_Mutation	p.R858T	1
GRM5	MESO	chr11	88386549	88386549	C	A	Missense_Mutation		1
GRM5	SARC	chr11	88300983	88300983	G	T	Missense_Mutation		1
GRM5	COAD	chr11	88258524	88258524	G	T	Missense_Mutation	p.F893L	1
GRM5	HNSC	chr11	88258477	88258477	C	A	Missense_Mutation		1
GRM5	SKCM	chr11	88780477	88780477	G	A	Silent	p.F188F	1
GRM5	LIHC	chr11	88242143	88242143	T	A	Missense_Mutation	p.S1086C	1
GRM5	BLCA	chr11	88780486	88780486	G	T	Missense_Mutation	p.F185L	1
GRM5	CESC	chr11	88718030	88718030	C	A	Missense_Mutation		1
GRM5	STAD	chr11	88300595	88300596	-	A	Frame_Shift_Ins	p.*752fs	1
GRM5	LUAD	chr11	88386527	88386527	C	A	Missense_Mutation	p.R319L	1
GRM5	BLCA	chr11	88780634	88780634	G	T	Missense_Mutation		1
GRM5	HNSC	chr11	88780494	88780494	T	C	Missense_Mutation		1
GRM5	LGG	chr11	88300406	88300406	G	T	Silent	p.G815G	1
GRM5	STAD	chr11	88780527	88780527	A	G	Missense_Mutation		1
GRM5	LUAD	chr11	88742218	88742218	A	T	Missense_Mutation	p.M237K	1
GRM5	HNSC	chr11	88242175	88242175	A	T	Missense_Mutation	p.L1075H	1
GRM5	SKCM	chr11	88300331	88300331	A	G	Silent	p.S840S	1
GRM5	LIHC	chr11	88338070	88338070	T	C	Missense_Mutation		1
GRM5	LUAD	chr11	88583079	88583079	C	G	Silent	p.L302L	1
GRM5	THYM	chr11	88300842	88300842	G	A	Missense_Mutation	p.A670V	1
GRM5	LUSC	chr11	88780463	88780463	G	A	Missense_Mutation	p.P193L	1
GRM5	BLCA	chr11	88323888	88323888	C	T	Missense_Mutation		1
GRM5	BLCA	chr11	88300723	88300723	C	A	Missense_Mutation	p.A710S	1
GRM5	LUSC	chr11	88300267	88300267	G	T	Missense_Mutation	p.L862I	1
GRM5	PRAD	chr11	88781128	88781128	G	A	Translation_Start_Site		1
GRM5	CHOL	chr11	88323785	88323785	G	T	Silent		1
GRM5	ESCA	chr11	88242134	88242134	C	T	Missense_Mutation		1
GRM5	MESO	chr11	88300544	88300544	G	A	Silent	p.N769N	1
GRM5	COAD	chr11	88300332	88300332	G	T	Missense_Mutation	p.S840Y	1
GRM5	HNSC	chr11	88338041	88338041	G	A	Silent		1
GRM5	KIRC	chr11	88780817	88780817	G	T	Missense_Mutation	p.T75N	1
GRM5	SKCM	chr11	88241879	88241879	C	T	Missense_Mutation	p.D1174N	1
GRM5	LIHC	chr11	88742219	88742219	T	A	Missense_Mutation	p.M237L	1
GRM5	CESC	chr11	88241873	88241873	C	A	Missense_Mutation		1
GRM5	STAD	chr11	88242507	88242507	G	A	Silent	p.G964G	1
GRM5	BLCA	chr11	88323882	88323882	C	G	Missense_Mutation		1
GRM5	COAD	chr11	88780859	88780859	C	T	Missense_Mutation	p.R61H	1
GRM5	HNSC	chr11	88241840	88241840	A	G	Missense_Mutation		1
GRM5	LGG	chr11	88338068	88338068	G	T	Silent	p.I404I	1
GRM5	HNSC	chr11	88717906	88717906	G	T	Missense_Mutation	p.P288T	1
GRM5	SKCM	chr11	88300332	88300332	G	A	Missense_Mutation	p.S840F	1
GRM5	LUAD	chr11	88780623	88780623	T	A	Nonsense_Mutation	p.K140*	1
GRM5	THYM	chr11	88780390	88780390	C	T	Silent	p.V217V	1
GRM5	LUSC	chr11	88583186	88583186	G	C	Missense_Mutation	p.H267D	1
GRM5	BLCA	chr11	88780576	88780576	G	T	Silent		1
GRM5	BLCA	chr11	88300897	88300897	C	A	Missense_Mutation	p.G652C	1
GRM5	LUSC	chr11	88780474	88780474	C	T	Missense_Mutation	p.M189I	1
GRM5	READ	chr11	88242010	88242010	G	A	Missense_Mutation	p.A1098V	1
GRM5	ESCA	chr11	88337964	88337964	T	C	Missense_Mutation		1
GRM5	BLCA	chr11	88780634	88780634	G	T	Missense_Mutation	p.S136Y	1
GRM5	CESC	chr11	88300848	88300848	C	T	Missense_Mutation	p.R668H	1
GRM5	MESO	chr11	88330390	88330390	A	G	Missense_Mutation	p.S509P	1
GRM5	COAD	chr11	88300452	88300452	A	G	Missense_Mutation	p.I800T	1
GRM5	HNSC	chr11	88386571	88386571	A	T	Missense_Mutation		1
GRM5	KIRC	chr11	88780658	88780658	C	A	Missense_Mutation	p.R128L	1
GRM5	SKCM	chr11	88241878	88241878	T	G	Missense_Mutation	p.D1174A	1
GRM5	LIHC	chr11	88242480	88242481	-	C	Frame_Shift_Ins	p.G973fs	1
GRM5	LUAD	chr11	88780650	88780650	C	T	Missense_Mutation	p.D131N	1
GRM5	LUAD	chr11	88301015	88301015	G	A	Silent	p.S612S	1
GRM5	STAD	chr11	88241901	88241901	C	T	Silent	p.P1166P	1
GRM5	BLCA	chr11	88780766	88780766	C	T	Missense_Mutation		1
GRM5	BLCA	chr11	88780523	88780523	G	C	Nonsense_Mutation	p.S173*	1
GRM5	COAD	chr11	88386398	88386398	C	T	Missense_Mutation	p.R362H	1
GRM5	HNSC	chr11	88780452	88780452	G	T	Missense_Mutation		1
GRM5	LGG	chr11	88323889	88323889	G	A	Nonsense_Mutation	p.R524*	1
GRM5	SKCM	chr11	88300835	88300835	G	A	Silent	p.I672I	1
GRM5	LUAD	chr11	88300463	88300463	G	T	Missense_Mutation	p.N796K	1
GRM5	LUSC	chr11	88386499	88386499	C	T	Silent	p.K328K	1
GRM5	UCS	chr11	88386450	88386450	G	A	Missense_Mutation		1
GRM5	LUSC	chr11	88300889	88300889	G	C	Silent	p.S654S	1
GRM5	CHOL	chr11	88323785	88323785	G	T	Silent	p.P558P	1
GRM5	ESCA	chr11	88583139	88583139	C	T	Silent	p.T282T	1
GRM5	BLCA	chr11	88323882	88323882	C	G	Missense_Mutation	p.G526A	1
GRM5	OV	chr11	87939936	87939936	C	T	Missense_Mutation		1
GRM5	SARC	chr11	88300983	88300983	G	T	Missense_Mutation	p.A623D	1
GRM5	COAD	chr11	88300813	88300815	TCT	-	In_Frame_Del	p.679_680del	1
GRM5	HNSC	chr11	88386529	88386529	C	A	Missense_Mutation		1
GRM5	SKCM	chr11	88241888	88241888	C	T	Missense_Mutation	p.D1171N	1
GRM5	LUAD	chr11	88386483	88386483	C	A	Missense_Mutation	p.V334F	1
GRM5	LUAD	chr11	88323860	88323860	G	T	Silent	p.T533T	1
GRM5	STAD	chr11	88781018	88781018	G	C	Nonsense_Mutation	p.S8*	1
GRM5	LUAD	chr11	88338056	88338056	G	C	Silent	p.A408A	1
GRM5	BLCA	chr11	88300776	88300776	G	A	Missense_Mutation		1
GRM5	BLCA	chr11	88242642	88242642	C	G	Missense_Mutation	p.Q919H	1
GRM5	DLBC	chr11	88338074	88338074	G	A	Silent	p.N402N	1
GRM5	HNSC	chr11	88780752	88780752	C	T	Missense_Mutation		1
GRM5	HNSC	chr11	88780522	88780522	T	A	Silent	p.S173S	1
GRM5	LGG	chr11	88242657	88242657	G	A	Silent	p.S914S	1
GRM5	HNSC	chr11	88386571	88386571	A	T	Splice_Site	p.S304_splice	1
GRM5	SKCM	chr11	88780634	88780634	G	A	Missense_Mutation	p.S136F	1
GRM5	STAD	chr11	88583222	88583222	G	T	Missense_Mutation	p.Q255K	1
GRM5	LUAD	chr11	88780926	88780926	C	A	Missense_Mutation	p.A39S	1
GRM5	LUSC	chr11	88337890	88337890	C	A	Nonsense_Mutation	p.G464*	1
GRM5	BLCA	chr11	88300616	88300616	T	A	Silent		1
GRM5	LUSC	chr11	88242498	88242498	T	C	Silent	p.A967A	1
GRM5	READ	chr11	88338110	88338110	A	C	Missense_Mutation	p.H390Q	1
GRM5	ESCA	chr11	88583110	88583110	C	A	Missense_Mutation	p.R292L	1
GRM5	OV	chr11	88780767	88780767	C	G	Missense_Mutation	p.G92R	1
GRM5	SARC	chr11	88583213	88583213	C	G	Missense_Mutation	p.D258H	1
GRM5	COAD	chr11	88300840	88300840	T	C	Missense_Mutation	p.R671G	1
GRM5	HNSC	chr11	88323788	88323788	C	A	Missense_Mutation		1
GRM5	SKCM	chr11	88780834	88780834	C	T	Silent	p.V69V	1
GRM5	LUAD	chr11	88330367	88330367	C	G	Missense_Mutation	p.E516D	1
GRM5	STAD	chr11	88300672	88300672	G	A	Nonsense_Mutation		1
GRM5	LUAD	chr11	88338057	88338057	G	C	Missense_Mutation	p.A408G	1
GRM5	BLCA	chr11	88337912	88337912	G	A	Silent		1
GRM5	SKCM	chr11	88241775	88241775	G	A	Silent	p.S1176S	1
GRM5	DLBC	chr11	88337922	88337922	G	A	Missense_Mutation	p.T453M	1
GRM5	HNSC	chr11	88780452	88780452	G	T	Missense_Mutation	p.Q197K	1
GRM5	GBM	chr11	88338071	88338071	G	A	Silent	p.A403A	1
GRM5	SKCM	chr11	88301126	88301126	C	T	Nonsense_Mutation	p.W575*	1
GRM5	LUSC	chr11	88780906	88780906	G	T	Missense_Mutation	p.H45Q	1
GRM5	BLCA	chr11	88780504	88780504	C	G	Silent		1
GRM5	CESC	chr11	88780994	88780994	A	G	Missense_Mutation		1
GRM5	LUSC	chr11	88780921	88780921	G	C	Silent	p.L40L	1
GRM5	READ	chr11	88337993	88337993	C	A	Missense_Mutation	p.M429I	1
GRM5	COAD	chr11	88242020	88242020	C	T	Missense_Mutation	p.A1095T	1
GRM5	BLCA	chr11	88583186	88583186	G	T	Missense_Mutation	p.H267N	1
GRM5	PAAD	chr11	88242512	88242512	C	T	Missense_Mutation		1
GRM5	SARC	chr11	88330491	88330491	C	T	Missense_Mutation	p.G475E	1
GRM5	COAD	chr11	88301038	88301038	G	A	Missense_Mutation	p.R605C	1
GRM5	KIRC	chr11	88242235	88242235	C	-	Frame_Shift_Del	p.G1055fs	1
GRM5	SKCM	chr11	88337902	88337902	C	T	Missense_Mutation	p.G460R	1
GRM5	LIHC	chr11	88242200	88242200	G	-	Frame_Shift_Del	p.R1067fs	1
GRM5	LUAD	chr11	88301013	88301013	G	C	Nonsense_Mutation	p.S613*	1
GRM5	LUAD	chr11	88300380	88300380	A	T	Missense_Mutation	p.I824N	1
GRM5	BLCA	chr11	88583186	88583186	G	T	Missense_Mutation		1
GRM5	HNSC	chr11	88780522	88780522	T	A	Silent		1
GRM5	HNSC	chr11	88241840	88241840	A	G	Missense_Mutation	p.S1187P	1
GRM5	SKCM	chr11	88780707	88780707	A	G	Missense_Mutation	p.F112L	1
GRM5	LGG	chr11	88242605	88242605	G	A	Missense_Mutation		1
GRM5	COAD	chr11	88242043	88242043	G	A	Missense_Mutation	p.P1087L	1
GRM5	GBM	chr11	88242179	88242179	C	G	Missense_Mutation	p.E1074Q	1
GRM5	HNSC	chr11	88300970	88300970	C	A	Silent	p.L627L	1
GRM5	SKCM	chr11	88338100	88338100	C	T	Missense_Mutation	p.D394N	1
GRM5	UCEC	chr11	88242206	88242206	C	T	Missense_Mutation	p.V1065I	1
GRM5	LUSC	chr11	88300727	88300727	G	T	Silent	p.I708I	1
GRM5	BLCA	chr11	88258484	88258484	T	C	Missense_Mutation		1
GRM5	LUSC	chr11	88780705	88780705	G	C	Missense_Mutation	p.F112L	1

Copy number variation (CNV) of GRM5
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across GRM5
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
99104	LUAD	TCGA-44-7660-01A	CTSC	chr11	88068105	-	GRM5	chr11	88242672	-
92679	N/A	AX185434	GRM5	chr11	88730435	-	EXT1	chr8	119101276	+
95614	.	.	GRM5	chr11	88630320	-	FAT3	chr11	92273213	+
95196	N/A	EC524987	GRM5	chr11	88422470	+	RCBTB1	chr13	50106403	+
96594	N/A	CB050374	GRM5	chr11	88349576	+	RET	chr10	43625799	-
72698	N/A	EC575283	GRM5	chr11	88300013	-	RPL41	chr12	56511345	+
92637	N/A	DB175186	GRM5	chr11	88766472	-	SF3A3	chr1	38455694	-
97235	N/A	FN121357	GRM5	chr11	88501385	+	TPH2	chr12	72430534	+
94720	N/A	DL059954	GRM5	chr11	88653574	-	TSPAN16	chr19	11435098	+
100717	N/A	AA308002	GRM5	chr11	88244579	-	VAPA	chr18	9936982	+
99104	N/A	FN090508	NALCN	chr13	101960103	+	GRM5	chr11	88279241	+
99104	N/A	CA454718	PROCR	chr20	33764777	+	GRM5	chr11	88510229	-
99104	PRAD	TCGA-EJ-7115-01A	TMEM135	chr11	87006865	-	GRM5	chr11	88242672	-
99104	BRCA	TCGA-A7-A2KD-01A	TMEM98	chr17	31263465	+	GRM5	chr11	88301160	-
99104	LUAD	TCGA-91-6831-01A	TTC33	chr5	40755926	-	GRM5	chr11	88242672	-
99110	N/A	FN053635	WDR7	chr18	54487310	+	GRM5	chr11	88775688	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
PAAD	GRM5	0.00209097834249418	0.059
LUSC	GRM5	0.00346976210720838	0.094
TGCT	GRM5	0.00714157939443247	0.19
ESCA	GRM5	0.0194597480354275	0.49
BRCA	GRM5	0.0474336862078996	1

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
PRAD	GRM5	0.0111566804584783	0.36
PAAD	GRM5	0.0325484541909865	1
ESCA	GRM5	0.00862694086528113	0.28

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
P41594	DB00659	Acamprosate	Antagonist	Small molecule	Approved\|Investigational
P41594	DB05070	ADX10059		Small molecule	Investigational
P41594	DB06201	Rufinamide	Inhibitor	Small molecule	Approved
P41594	DB12733	Dipraglurant		Small molecule	Investigational
P41594	DB00659	Acamprosate	Antagonist
P41594	DB05070	ADX10059
P41594	DB06201	Rufinamide	Inhibitor
P41594	DB12733	Dipraglurant

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0036341	Schizophrenia	3	PSYGENET
C0041696	Unipolar Depression	3	PSYGENET
C1269683	Major Depressive Disorder	3	PSYGENET
C0038220	Status Epilepticus	2	CTD_human
C0041671	Attention Deficit Disorder	2	CTD_human
C0270823	Petit mal status	2	CTD_human
C0311335	Grand Mal Status Epilepticus	2	CTD_human
C0393734	Complex Partial Status Epilepticus	2	CTD_human
C0751522	Status Epilepticus, Subclinical	2	CTD_human
C0751523	Non-Convulsive Status Epilepticus	2	CTD_human
C1263846	Attention deficit hyperactivity disorder	2	CTD_human
C1321905	Minimal Brain Dysfunction	2	CTD_human
C0005586	Bipolar Disorder	1	PSYGENET
C0009171	Cocaine Abuse	1	CTD_human
C0014556	Epilepsy, Temporal Lobe	1	CTD_human
C0014558	Uncinate Epilepsy	1	CTD_human
C0029231	Organic Mental Disorders, Substance-Induced	1	CTD_human
C0038580	Substance Dependence	1	CTD_human
C0271673	Symmetric Diabetic Proximal Motor Neuropathy	1	CTD_human
C0271674	Asymmetric Diabetic Proximal Motor Neuropathy	1	CTD_human
C0271678	Diabetic Mononeuropathy	1	CTD_human
C0271685	Diabetic Amyotrophy	1	CTD_human
C0271686	Diabetic Autonomic Neuropathy	1	CTD_human
C0393672	Epilepsy, Benign Psychomotor, Childhood	1	CTD_human
C0393682	Epilepsy, Lateral Temporal	1	CTD_human
C0393835	Diabetic Asymmetric Polyneuropathy	1	CTD_human
C0600427	Cocaine Dependence	1	CTD_human
C0740858	Substance abuse problem	1	CTD_human
C0751074	Diabetic Neuralgia	1	CTD_human