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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: EEF2K (NCBI Gene ID:29904)

Gene Summary

Gene Summary

Gene Information	Gene Name: EEF2K
	Gene ID: 29904
	Gene Symbol	EEF2K
	Gene ID	29904
	Gene Name	eukaryotic elongation factor 2 kinase
	Synonyms	CaMKIII\|HSU93850\|eEF-2K
	Cytomap	16p12.2
	Type of Gene	protein-coding
	Description	eukaryotic elongation factor 2 kinasealternative protein EEF2Kcalcium/calmodulin-dependent eukaryotic elongation factor-2 kinasecalmodulin-dependent protein kinase IIIeEF-2 kinaseelongation factor-2 kinaseeukaroytic elongation factor 2 kinase
	Modification date	20200313
	UniProtAcc	O00418

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0008135	Translation factor activity, RNA binding
GO:0006414	Translational elongation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	EEF2K	GO:0046777	protein autophosphorylation	9144159\|23184662

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
EEF2K	(733 - 1119.25]

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Translation Studies in PubMed

We searched PubMed using 'EEF2K[title] AND translation [title] AND human.'

Gene	Title	PMID
EEF2K	eEF2K enhances expression of PD-L1 by promoting the translation of its mRNA	33094805

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

ORF

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
LUAD	EEF2K	-1.7131135520626	0.00809975492282352
CHOL	EEF2K	-1.2949964268881	0.01171875
KIRC	EEF2K	-2.65698628873261	1.28330819964462e-11
KIRP	EEF2K	-3.22284286753124	1.73319131135941e-06
BRCA	EEF2K	-1.03929872081212	2.25870478012991e-13

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
CESC	EEF2K	hsa-miR-196a-5p	94	0.315344878829245	0.00492006915959941
DLBC	EEF2K	hsa-let-7i-5p	94	0.374537465309898	0.00988790199497715

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
UCEC	EEF2K	-0.139076817	0.0211814
COAD	EEF2K	0.024904282	0.021794014
THYM	EEF2K	0.10775651	0.034577627
LGG	EEF2K	-0.045419266	0.043248593

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with EEF2K (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type

Gene group

Translation factor

Correlated gene

Coefficient

Pvalue

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
COAD	EEF2K	CALM2	-2.73822414406398	0.000109195709228516
LUAD	EEF2K	PRKCG	-1.32216588872022	0.00015397121496344
PRAD	EEF2K	RPS6KB1	1.25047501981198	0.000199084406212897
HNSC	EEF2K	EEF2	-1.90805330069302	0.000299885096865183
HNSC	EEF2K	PRKCA	-1.05859058726713	0.000333792391984389
PRAD	EEF2K	CALM2	-1.36008937047426	0.000529873135893225
THCA	EEF2K	EEF2	1.35574858496176	0.000711089919756285
COAD	EEF2K	RPS6KB1	-1.1133069567678	0.00144392251968384
COAD	EEF2K	EEF2	1.67025113686866	0.00197160243988037
STAD	EEF2K	PRKCB	-1.21619184184651	0.00361521635204554
CHOL	EEF2K	PRKAA1	-3.44971492103355	0.00390625
COAD	EEF2K	PRKCA	-1.15779532669608	0.00729089975357057
STAD	EEF2K	EEF2	-1.87846190344448	0.00733334058895707
CHOL	EEF2K	PRKAA2	3.72411602782518	0.0078125
ESCA	EEF2K	EEF2	-3.4598326417414	0.0185546875
BLCA	EEF2K	CALM2	-2.15295781334787	0.0229873657226562
BRCA	EEF2K	PRKCB	1.17086440813567	0.0277615901628753
HNSC	EEF2K	RPS6KB1	-1.27996809705029	0.0301271170746986
READ	EEF2K	CALM2	-4.27349751272941	0.03125
CHOL	EEF2K	PRKCG	-3.11715915357116	0.0346105575157073
PRAD	EEF2K	PRKCA	-3.47666621249232	1.35699423901536e-06
LIHC	EEF2K	PRKAA1	-2.48366285605802	1.81873379105532e-05
KIRC	EEF2K	PRKCA	-2.05183038862479	1.84821705533328e-12
KIRP	EEF2K	RPS6KB1	-1.46465474284348	2.00420618057251e-06
LUSC	EEF2K	PRKCB	-9.9038295783078	2.42825252900713e-09
PRAD	EEF2K	EEF2	1.63926479894191	2.70126293247147e-08
THCA	EEF2K	PRKCA	1.9298021549374	5.35914250842086e-10
KICH	EEF2K	PRKCB	3.5450947253756	5.96046447753906e-07
KIRC	EEF2K	CALM2	1.44317896510924	6.02390727604811e-08
BRCA	EEF2K	PRKCA	1.95237423033604	7.45942677942127e-26
PRAD	EEF2K	PRKCB	-5.09437270679127	9.832185977576e-07

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with EEF2K

RPS6KA1, RPS6KB1, ELAVL1, BTRC, FBXW11, SKP1, EEF2, CDK1, DENR, ALB, ACADVL, METAP2, PA2G4, EIF4A3, ACTR2, CALR, DPP9, DUS3L, AARS, CALU, OSGEP, THG1L, PANK4, PRKAR1B, RANGAP1, TP53RK, UBE3C, SRP14, SRP9, RAE1, ACACA, WDFY3, FKBP6, XPO1, EZR, AGO2, nsp2, HSPA12B, TULP3, PFN1, EPB41L3, CLTCL1, RBP1, EPB41L1, EPB41, SPRR1B, SLFN11, N,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
EEF2K	BLCA	chr16	22291646	22291646	G	A	Missense_Mutation	p.E673K	7
EEF2K	ESCA	chr16	22295238	22295238	C	T	Missense_Mutation	p.A700V	6
EEF2K	COAD	chr16	22262606	22262606	G	-	Frame_Shift_Del	p.W194fs	5
EEF2K	BLCA	chr16	22262514	22262514	C	A	Silent		5
EEF2K	BRCA	chr16	22291592	22291592	G	T	Nonsense_Mutation	p.E655*	5
EEF2K	STAD	chr16	22268122	22268122	C	G	Silent		4
EEF2K	STAD	chr16	22268122	22268122	C	G	Silent	p.P224P	4
EEF2K	COAD	chr16	22256035	22256035	C	T	Missense_Mutation	p.R111C	4
EEF2K	KIRP	chr16	22237117	22237117	C	T	Missense_Mutation	p.H23Y	4
EEF2K	LUAD	chr16	22268069	22268069	G	T	Splice_Site	p.V207_splice	4
EEF2K	BRCA	chr16	22268146	22268146	C	T	Silent	p.I232	4
EEF2K	LIHC	chr16	22269862	22269862	C	-	Frame_Shift_Del	p.S359fs	3
EEF2K	UCS	chr16	22278135	22278135	G	A	Missense_Mutation	p.V568M	3
EEF2K	COAD	chr16	22268599	22268599	G	A	Missense_Mutation	p.R265H	3
EEF2K	UCEC	chr16	22277718	22277718	T	C	Missense_Mutation	p.V483A	3
EEF2K	LUAD	chr16	22256000	22256000	G	T	Missense_Mutation	p.W99L	3
EEF2K	BRCA	chr16	22260122	22260122	A	C	Missense_Mutation	p.K132Q	3
EEF2K	HNSC	chr16	22260121	22260121	C	G	Missense_Mutation	p.I131M	3
EEF2K	UCEC	chr16	22291547	22291547	T	C	Missense_Mutation	p.W640R	3
EEF2K	READ	chr16	22268969	22268969	C	T	Missense_Mutation	p.R303C	3
EEF2K	UCEC	chr16	22277813	22277813	G	A	Missense_Mutation	p.E515K	2
EEF2K	CHOL	chr16	22237252	22237252	C	T	Missense_Mutation		2
EEF2K	SKCM	chr16	22262479	22262479	C	T	Missense_Mutation	p.L152F	2
EEF2K	UCEC	chr16	22291669	22291669	C	T	Silent	p.Y680	2
EEF2K	CESC	chr16	22260107	22260107	G	C	Missense_Mutation		2
EEF2K	CHOL	chr16	22237252	22237252	C	T	Missense_Mutation	p.R68W	2
EEF2K	SKCM	chr16	22268607	22268607	C	T	Missense_Mutation	p.H268Y	2
EEF2K	UCEC	chr16	22237147	22237147	G	A	Missense_Mutation	p.D33N	2
EEF2K	BLCA	chr16	22269882	22269882	C	T	Missense_Mutation	p.S366F	2
EEF2K	HNSC	chr16	22271842	22271842	A	T	Missense_Mutation	p.N431Y	2
EEF2K	PRAD	chr16	22260091	22260091	C	T	Silent	p.T121T	2
EEF2K	CESC	chr16	22268579	22268579	C	T	Silent		2
EEF2K	SKCM	chr16	22268095	22268095	C	T	Silent	p.I215I	2
EEF2K	BLCA	chr16	22291646	22291646	G	A	Missense_Mutation		2
EEF2K	UCEC	chr16	22237173	22237173	C	A	Silent	p.P41	2
EEF2K	STAD	chr16	22291579	22291579	T	C	Silent	p.C650C	2
EEF2K	SKCM	chr16	22269973	22269973	C	T	Silent	p.S396S	2
EEF2K	UCEC	chr16	22237179	22237179	G	A	Silent	p.T43	2
EEF2K	PRAD	chr16	22278045	22278045	C	T	Missense_Mutation	p.R538C	2
EEF2K	STAD	chr16	22237143	22237143	C	T	Silent	p.S31S	2
EEF2K	CESC	chr16	22237288	22237288	C	T	Missense_Mutation		2
EEF2K	SKCM	chr16	22262007	22262007	C	T	Silent	p.F147F	2
EEF2K	LUAD	chr16	22237269	22237269	G	T	Silent	p.G73G	2
EEF2K	UCEC	chr16	22256034	22256034	A	G	Silent	p.E110	2
EEF2K	ESCA	chr16	22262558	22262558	G	T	Missense_Mutation	p.R178L	2
EEF2K	STAD	chr16	22271788	22271788	C	T	Missense_Mutation	p.P413S	2
EEF2K	SKCM	chr16	22269896	22269896	C	T	Missense_Mutation	p.P371S	2
EEF2K	UCEC	chr16	22256045	22256045	G	A	Missense_Mutation	p.R114Q	2
EEF2K	BRCA	chr16	22262009	22262009	G	A	Missense_Mutation	p.R148Q	2
EEF2K	LIHC	chr16	22291635	22291635	C	T	Missense_Mutation		2
EEF2K	CESC	chr16	22268648	22268648	C	G	Silent		2
EEF2K	SKCM	chr16	22237185	22237185	C	T	Silent	p.D45D	2
EEF2K	SKCM	chr16	22278176	22278176	C	T	Silent	p.I581I	2
EEF2K	UCEC	chr16	22260105	22260105	A	G	Missense_Mutation	p.D126G	2
EEF2K	BRCA	chr16	22295264	22295264	G	A	Missense_Mutation	p.A709T	2
EEF2K	ESCA	chr16	22295238	22295238	C	T	Missense_Mutation		2
EEF2K	STAD	chr16	22278169	22278169	A	T	Missense_Mutation	p.H579L	2
EEF2K	HNSC	chr16	22271782	22271782	G	C	Splice_Site		2
EEF2K	SKCM	chr16	22237194	22237194	G	A	Silent	p.S48S	2
EEF2K	COAD	chr16	22269821	22269821	G	T	Missense_Mutation	p.A346S	2
EEF2K	KIRP	chr16	22291562	22291562	C	A	Missense_Mutation		2
EEF2K	UCEC	chr16	22268994	22268994	C	A	Missense_Mutation	p.S311Y	2
EEF2K	UCEC	chr16	22276176	22276176	A	G	Missense_Mutation	p.E472G	2
EEF2K	LIHC	chr16	22262548	22262548	C	-	Frame_Shift_Del	p.P175fs	2
EEF2K	SKCM	chr16	22269960	22269960	C	T	Missense_Mutation	p.S392F	2
EEF2K	LUAD	chr16	22262545	22262545	G	T	Nonsense_Mutation	p.E174*	2
EEF2K	UCEC	chr16	22277722	22277722	G	T	Missense_Mutation	p.E484D	2
EEF2K	GBM	chr16	22274454	22274454	C	T	Silent		2
EEF2K	LIHC	chr16	22295308	22295308	G	-	Frame_Shift_Del	p.M723fs	2
EEF2K	SKCM	chr16	22278015	22278015	C	T	Silent	p.L528L	2
EEF2K	BLCA	chr16	22237249	22237249	G	A	Missense_Mutation	p.E67K	2
EEF2K	HNSC	chr16	22271832	22271832	T	G	Missense_Mutation	p.D427E	2
EEF2K	LGG	chr16	22262474	22262474	A	C	Missense_Mutation	p.K150T	1
EEF2K	PAAD	chr16	22295283	22295283	A	C	Missense_Mutation	p.K715T	1
EEF2K	BRCA	chr16	22237273	22237273	C	G	Missense_Mutation	p.P75A	1
EEF2K	GBM	chr16	22285035	22285035	G	A	Missense_Mutation		1
EEF2K	SARC	chr16	22276140	22276140	G	T	Missense_Mutation		1
EEF2K	TGCT	chr16	22291564	22291564	G	T	Silent	p.L645L	1
EEF2K	SKCM	chr16	22268129	22268129	C	T	Missense_Mutation	p.H227Y	1
EEF2K	UCEC	chr16	22291582	22291582	T	C	Silent	p.D651D	1
EEF2K	COAD	chr16	22285033	22285033	G	A	Silent	p.A617A	1
EEF2K	HNSC	chr16	22268675	22268675	G	A	Silent	p.E290E	1
EEF2K	LUAD	chr16	22269882	22269882	C	G	Missense_Mutation	p.S366C	1
EEF2K	LGG	chr16	22269826	22269826	G	T	Missense_Mutation	p.K347N	1
EEF2K	PAAD	chr16	22268113	22268113	G	A	Silent	p.P221P	1
EEF2K	HNSC	chr16	22271842	22271842	A	T	Missense_Mutation		1
EEF2K	THCA	chr16	22268620	22268620	T	A	Missense_Mutation		1
EEF2K	BLCA	chr16	22237249	22237249	G	A	Missense_Mutation		1
EEF2K	LIHC	chr16	22269972	22269972	C	-	Frame_Shift_Del	p.S396fs	1
EEF2K	SARC	chr16	22276191	22276191	G	T	Missense_Mutation		1
EEF2K	LUAD	chr16	22277709	22277709	A	C	Splice_Site		1
EEF2K	SKCM	chr16	22295301	22295301	C	T	Missense_Mutation	p.A721V	1
EEF2K	COAD	chr16	22291688	22291688	C	T	Nonsense_Mutation	p.Q687X	1
EEF2K	LGG	chr16	22291686	22291686	C	A	Missense_Mutation		1
EEF2K	STAD	chr16	22268610	22268610	C	T	Nonsense_Mutation	p.Q269X	1
EEF2K	UCS	chr16	22278135	22278135	G	A	Missense_Mutation		1
EEF2K	HNSC	chr16	22291535	22291535	G	C	Missense_Mutation		1
EEF2K	THYM	chr16	22277817	22277817	A	G	Missense_Mutation		1
EEF2K	LIHC	chr16	22291616	22291616	C	-	Frame_Shift_Del	p.P663fs	1
EEF2K	SARC	chr16	22256002	22256002	G	T	Missense_Mutation		1
EEF2K	HNSC	chr16	22271782	22271782	G	C	Splice_Site	p.H411_splice	1
EEF2K	LUAD	chr16	22269092	22269092	G	A	Splice_Site		1
EEF2K	SKCM	chr16	22262483	22262483	C	T	Missense_Mutation	p.S153F	1
EEF2K	BLCA	chr16	22285043	22285043	G	A	Missense_Mutation	p.D621N	1
EEF2K	ESCA	chr16	22262606	22262606	G	-	Frame_Shift_Del	p.E196fs	1
EEF2K	LIHC	chr16	22284965	22284965	A	G	Missense_Mutation		1
EEF2K	PRAD	chr16	22260135	22260135	A	G	Missense_Mutation	p.Q136R	1
EEF2K	CESC	chr16	22276157	22276157	C	A	Silent		1
EEF2K	HNSC	chr16	22271832	22271832	T	G	Missense_Mutation		1
EEF2K	THYM	chr16	22237211	22237211	C	T	Missense_Mutation		1
EEF2K	BLCA	chr16	22269882	22269882	C	T	Missense_Mutation		1
EEF2K	COAD	chr16	22262557	22262557	C	T	Missense_Mutation	p.R178W	1
EEF2K	LIHC	chr16	22237278	22237278	A	-	Frame_Shift_Del	p.A76fs	1
EEF2K	SARC	chr16	22274469	22274469	G	A	Silent		1
EEF2K	LUAD	chr16	22268069	22268069	G	T	Missense_Mutation	p.V207L	1
EEF2K	SKCM	chr16	22278092	22278092	C	T	Silent	p.F553F	1
EEF2K	BLCA	chr16	22262572	22262572	G	C	Missense_Mutation	p.E183Q	1
EEF2K	LIHC	chr16	22277733	22277733	T	C	Missense_Mutation		1
EEF2K	HNSC	chr16	22262550	22262550	C	A	Silent		1
EEF2K	UCEC	chr16	22256021	22256021	A	T	Missense_Mutation	p.D106V	1
EEF2K	BLCA	chr16	22285043	22285043	G	A	Missense_Mutation		1
EEF2K	SARC	chr16	22274469	22274469	G	A	Silent	p.E446	1
EEF2K	KIRP	chr16	22274500	22274500	C	T	Nonsense_Mutation		1
EEF2K	LUAD	chr16	22277709	22277709	A	C	Splice_Site	p.V481_splice	1
EEF2K	SKCM	chr16	22255972	22255972	C	T	Nonsense_Mutation	p.Q90*	1
EEF2K	BLCA	chr16	22291571	22291571	A	T	Missense_Mutation	p.T648S	1
EEF2K	LIHC	chr16	22276179	22276179	A	G	Missense_Mutation		1
EEF2K	PRAD	chr16	22268671	22268671	C	T	Missense_Mutation	p.T289M	1
EEF2K	CESC	chr16	22268678	22268678	G	T	Silent		1
EEF2K	HNSC	chr16	22269984	22269984	C	T	Missense_Mutation		1
EEF2K	UCEC	chr16	22255966	22255966	G	A	Missense_Mutation	p.A88T	1
EEF2K	BLCA	chr16	22271812	22271812	A	G	Missense_Mutation		1
EEF2K	LUAD	chr16	22269910	22269910	C	T	Silent	p.P375P	1
EEF2K	SKCM	chr16	22269866	22269866	C	T	Nonsense_Mutation	p.Q361X	1
EEF2K	KIRP	chr16	22291588	22291588	C	T	Silent		1
EEF2K	LUSC	chr16	22269837	22269837	G	A	Missense_Mutation	p.R351K	1
EEF2K	SKCM	chr16	22269866	22269866	C	T	Nonsense_Mutation	p.Q361*	1
EEF2K	ESCA	chr16	22261980	22261980	C	T	Silent		1
EEF2K	PRAD	chr16	22260137	22260137	G	T	Splice_Site		1
EEF2K	STAD	chr16	22269981	22269981	C	T	Missense_Mutation	p.S399L	1
EEF2K	HNSC	chr16	22268675	22268675	G	A	Silent		1
EEF2K	COAD	chr16	22268698	22268698	G	A	Missense_Mutation	p.G298D	1
EEF2K	KIRP	chr16	22237117	22237117	C	T	Missense_Mutation		1
EEF2K	LUSC	chr16	22262526	22262526	C	T	Silent	p.Y167Y	1
EEF2K	SKCM	chr16	22269865	22269865	C	T	Silent	p.P360P	1
EEF2K	LIHC	chr16	22291589	22291589	G	A	Missense_Mutation	p.G654S	1
EEF2K	PRAD	chr16	22268604	22268604	G	A	Missense_Mutation	p.G267S	1
EEF2K	CESC	chr16	22237288	22237288	C	T	Missense_Mutation	p.H80Y	1
EEF2K	UCEC	chr16	22237173	22237173	C	A	Silent	p.P41P	1
EEF2K	BLCA	chr16	22262572	22262572	G	C	Missense_Mutation		1
EEF2K	LUSC	chr16	22261999	22261999	G	T	Nonsense_Mutation	p.E145*	1
EEF2K	SKCM	chr16	22269972	22269972	C	T	Missense_Mutation	p.S396F	1
EEF2K	ESCA	chr16	22261980	22261980	C	T	Silent	p.F138F	1
EEF2K	LIHC	chr16	22269906	22269906	G	A	Missense_Mutation	p.R374H	1
EEF2K	READ	chr16	22255965	22255965	C	T	Silent	p.H87H	1
EEF2K	SKCM	chr16	22255972	22255972	C	T	Nonsense_Mutation	p.Q90X	1
EEF2K	STAD	chr16	22268982	22268984	TCT	-	In_Frame_Del	p.LF307del	1
EEF2K	CESC	chr16	22260107	22260107	G	C	Missense_Mutation	p.D127H	1
EEF2K	SKCM	chr16	22285017	22285017	C	T	Missense_Mutation	p.S612F	1
EEF2K	BLCA	chr16	22261995	22261995	G	A	Missense_Mutation		1
EEF2K	COAD	chr16	22269946	22269946	C	T	Silent	p.D387D	1
EEF2K	LUAD	chr16	22268994	22268994	C	G	Missense_Mutation	p.S311C	1
EEF2K	KIRP	chr16	22295229	22295229	C	T	Missense_Mutation		1
EEF2K	LUSC	chr16	22237271	22237271	C	G	Missense_Mutation	p.S74C	1
EEF2K	SKCM	chr16	22262623	22262623	C	T	Missense_Mutation	p.R200W	1
EEF2K	GBM	chr16	22269944	22269944	G	A	Missense_Mutation		1
EEF2K	CESC	chr16	22268579	22268579	C	T	Silent	p.F258	1
EEF2K	HNSC	chr16	22268648	22268648	C	G	Silent	p.L281L	1
EEF2K	STAD	chr16	22260086	22260086	G	A	Missense_Mutation	p.V120I	1
EEF2K	SKCM	chr16	22268203	22268203	C	T	Silent	p.I251I	1
EEF2K	UCEC	chr16	22268655	22268655	G	A	Missense_Mutation	p.D284N	1
EEF2K	BLCA	chr16	22291571	22291571	A	T	Missense_Mutation		1
EEF2K	COAD	chr16	22274439	22274439	G	T	Missense_Mutation	p.E436D	1
EEF2K	HNSC	chr16	22269984	22269984	C	T	Missense_Mutation	p.A400V	1
EEF2K	LGG	chr16	22291526	22291526	G	A	Missense_Mutation	p.D633N	1
EEF2K	OV	chr16	22185533	22185533	C	G	Nonsense_Mutation		1
EEF2K	STAD	chr16	22268982	22268984	TCT	-	In_Frame_Del		1
EEF2K	CESC	chr16	22268678	22268678	G	T	Silent	p.T291	1
EEF2K	SARC	chr16	22237118	22237118	A	G	Missense_Mutation		1
EEF2K	STAD	chr16	22268610	22268610	C	T	Nonsense_Mutation	p.Q269*	1
EEF2K	SKCM	chr16	22269008	22269008	C	T	Missense_Mutation	p.R316W	1
EEF2K	UCEC	chr16	22237179	22237179	G	A	Silent	p.T43T	1
EEF2K	COAD	chr16	22278105	22278105	G	A	Missense_Mutation	p.A558T	1
EEF2K	LUAD	chr16	22274454	22274454	C	T	Silent	p.S441S	1

Copy number variation (CNV) of EEF2K
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across EEF2K
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
58628	KIRP	TCGA-BQ-5887	EEF2K	chr16	22262643	+	ACSM3	chr16	20781305	+
58628	KIRP	TCGA-BQ-5887-01A	EEF2K	chr16	22262643	+	ACSM3	chr16	20781306	+
87795	N/A	BM153244	EEF2K	chr16	22253698	+	BIRC5	chr17	76221106	-
94710	LUSC	TCGA-77-6845	EEF2K	chr16	22218000	+	C10orf35	chr10	71391235	+
94710	LUSC	TCGA-77-6845-01A	EEF2K	chr16	22218000	+	C10orf35	chr10	71391236	+
95770	LUAD	TCGA-78-7150-01A	EEF2K	chr16	22268706	+	KCTD1	chr18	24081214	-
90360	KIRC	TCGA-CJ-4888-01A	EEF2K	chr16	22237296	+	N4BP2L2	chr13	33095586	-
103257	N/A	BG151697	EEF2K	chr16	22252780	-	PTPRT	chr20	41792305	-
71257	STAD	TCGA-VQ-A92D-01A	EEF2K	chr16	22218000	+	SDR42E2	chr16	22192840	+
100801	BRCA	TCGA-BH-A0B9-01A	EEF2K	chr16	22276201	+	UQCRC2	chr16	21982846	+
100801	BRCA	TCGA-E2-A14N	EEF2K	chr16	22218000	+	UQCRC2	chr16	21991867	+
96241	BRCA	TCGA-C8-A12Q-01A	EEF2K	chr16	22285071	+	VWA3A	chr16	22155568	+
96241	BRCA	TCGA-OL-A66P-01A	EEF2K	chr16	22256051	+	VWA3A	chr16	22149681	+
96241	LIHC	TCGA-G3-AAV1-01A	EEF2K	chr16	22237296	+	VWA3A	chr16	22157557	+
90030	STAD	TCGA-CD-8531-01A	HNRNPM	chr19	8532468	+	EEF2K	chr16	22284947	+
90030	BLCA	TCGA-GC-A4ZW-01A	KIAA0430	chr16	15694285	-	EEF2K	chr16	22291519	+
90031	N/A	CB050994	TEKT5	chr16	10767300	+	EEF2K	chr16	22297947	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRC	EEF2K	0.00737489988163272	0.21
TGCT	EEF2K	0.0161395964788697	0.44
ACC	EEF2K	0.0306902531461452	0.8
BLCA	EEF2K	0.0489279800225428	1

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LGG	EEF2K	0.00572141402069615	0.18
LAML	EEF2K	0.00533729974190398	0.17
BRCA	EEF2K	0.0251070507200243	0.72
SKCM	EEF2K	0.0241660976202135	0.72
OV	EEF2K	0.00162248885788475	0.054
PCPG	EEF2K	0.0245732945191418	0.72

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source