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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPSA (NCBI Gene ID:3921)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPSA
	Gene ID: 3921
	Gene Symbol	RPSA
	Gene ID	3921
	Gene Name	ribosomal protein SA
	Synonyms	37LRP\|67LR\|ICAS\|LAMBR\|LAMR1\|LBP\|LBP/p40\|LRP\|LRP/LR\|NEM/1CHD4\|SA\|lamR\|p40
	Cytomap	3p22.1
	Type of Gene	protein-coding
	Description	40S ribosomal protein SA37 kDa laminin receptor37/67 kDa laminin receptor67 kDa laminin receptorcolon carcinoma laminin-binding proteinlaminin receptor 1 (67kD, ribosomal protein SA)laminin-binding protein precursor p40multidrug resistance-associat
	Modification date	20200313
	UniProtAcc	P08865

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
RPSA	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'RPSA[title] AND translation [title] AND human.'

Gene	Title	PMID
RPSA	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000301821	39450096	39450215	Frame-shift
ENST00000301821	39452244	39452490	In-frame
ENST00000301821	39453139	39453268	In-frame
ENST00000301821	39453386	39453552	Frame-shift

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000301821	39452244	39452490	1188	362	607	295	84	166
ENST00000301821	39453139	39453268	1188	608	736	295	166	209

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
LIHC	RPSA	-2.66181804625988	0.00010013220697745
CHOL	RPSA	-1.88501253711962	0.0078125
PRAD	RPSA	1.15183588990872	0.0476188245531179

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
BLCA	RPSA	1	2	0.0348580598349416	0.135113875205254	0.252517857142857	-0.048830947242786	0.139522747338557

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
STAD	RPSA	2	1	0.0194108741833113	0.250082898550725	0.151735308641975	0.167365966589048	0.268608532343272

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
THCA	RPSA	0.181089249	0.007635067
KIRP	RPSA	-0.029756745	0.016038395
SARC	RPSA	-0.124122356	0.019227322

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPSA (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
DLBC	Cell metabolism gene	RPSA	FAU	0.802543775	6.92E-12
DLBC	Cell metabolism gene	RPSA	SNRPD2	0.834992809	1.62E-13
DLBC	Cell metabolism gene	RPSA	TIMM13	0.850035774	2.13E-14
DLBC	Epifactor	RPSA	FBL	0.866486652	1.77E-15
DLBC	IUPHAR	RPSA	SLC25A26	0.851853048	1.64E-14
DLBC	TSG	RPSA	GLTSCR2	0.840281243	8.12E-14
GBM	Cell metabolism gene	RPSA	SEC13	0.801453726	8.45E-40
GBM	Cell metabolism gene	RPSA	LSM3	0.818594949	8.60E-43
HNSC	Cell metabolism gene	RPSA	IMPDH2	0.812152889	4.36E-134
HNSC	IUPHAR	RPSA	IMPDH2	0.812152889	4.36E-134
KICH	Cell metabolism gene	RPSA	SNRPD2	0.806252783	5.32E-22
KICH	Cell metabolism gene	RPSA	IMPDH2	0.827391221	5.09E-24
KICH	IUPHAR	RPSA	IMPDH2	0.827391221	5.09E-24
LGG	Cell metabolism gene	RPSA	IMPDH2	0.81519156	2.51E-127
LGG	IUPHAR	RPSA	IMPDH2	0.81519156	2.51E-127
LIHC	Cell metabolism gene	RPSA	IMPDH2	0.800742727	9.65E-96
LIHC	Epifactor	RPSA	FBL	0.806489289	3.96E-98
LIHC	IUPHAR	RPSA	IMPDH2	0.800742727	9.65E-96
PRAD	Cell metabolism gene	RPSA	NME2	0.800351515	7.40E-124
PRAD	Cell metabolism gene	RPSA	FAU	0.815733937	2.15E-132
PRAD	Cell metabolism gene	RPSA	SNRPD2	0.816731281	5.65E-133
PRAD	Cell metabolism gene	RPSA	TIMM9	0.819371237	1.57E-134
PRAD	CGC	RPSA	NACA	0.805929059	7.29E-127
PRAD	Epifactor	RPSA	FBL	0.842402848	2.82E-149
PRAD	TF	RPSA	NME2	0.800351515	7.40E-124
PRAD	TF	RPSA	ZNF581	0.819784064	8.93E-135
PRAD	TSG	RPSA	GNB2L1	0.862434464	3.55E-164
THCA	Cell metabolism gene	RPSA	FAU	0.816221103	6.29E-138
THYM	Cell metabolism gene	RPSA	APRT	0.800014314	2.15E-28
THYM	Cell metabolism gene	RPSA	IMPDH2	0.803927744	7.45E-29
THYM	Cell metabolism gene	RPSA	PSMB3	0.8086633	2.00E-29
THYM	Cell metabolism gene	RPSA	PGLS	0.812190088	7.33E-30
THYM	Cell metabolism gene	RPSA	PFDN5	0.815511181	2.79E-30
THYM	Cell metabolism gene	RPSA	MTMR14	0.817637271	1.49E-30
THYM	Cell metabolism gene	RPSA	POLA2	0.8227409	3.20E-31
THYM	Cell metabolism gene	RPSA	PSMB7	0.824387906	1.92E-31
THYM	Cell metabolism gene	RPSA	SSR2	0.827086364	8.27E-32
THYM	Cell metabolism gene	RPSA	TALDO1	0.834535051	7.45E-33
THYM	Cell metabolism gene	RPSA	TIMM13	0.835672273	5.11E-33
THYM	Cell metabolism gene	RPSA	MVD	0.838575191	1.92E-33
THYM	Cell metabolism gene	RPSA	LSM2	0.839098309	1.61E-33
THYM	Cell metabolism gene	RPSA	POLD2	0.840022742	1.17E-33
THYM	Cell metabolism gene	RPSA	ACOT8	0.843207902	3.87E-34
THYM	Cell metabolism gene	RPSA	TIMM8B	0.845818659	1.53E-34
THYM	Cell metabolism gene	RPSA	FPGS	0.846082822	1.40E-34
THYM	Cell metabolism gene	RPSA	SLC27A5	0.849011	4.83E-35
THYM	Cell metabolism gene	RPSA	PSMD13	0.850759107	2.54E-35
THYM	Cell metabolism gene	RPSA	SNRPD2	0.864013392	1.45E-37
THYM	Cell metabolism gene	RPSA	PSMC3	0.870082842	1.13E-38
THYM	Cell metabolism gene	RPSA	FAU	0.901429227	1.89E-45
THYM	CGC	RPSA	BAP1	0.808049818	2.38E-29
THYM	CGC	RPSA	TFPT	0.833300557	1.12E-32
THYM	CGC	RPSA	SDHAF2	0.847453822	8.52E-35
THYM	CGC	RPSA	RBM10	0.864823507	1.04E-37
THYM	Epifactor	RPSA	RRP8	0.800191828	2.05E-28
THYM	Epifactor	RPSA	CCDC101	0.800728277	1.78E-28
THYM	Epifactor	RPSA	BAP1	0.808049818	2.38E-29
THYM	Epifactor	RPSA	C17orf49	0.809842682	1.43E-29
THYM	Epifactor	RPSA	PRPF31	0.817932621	1.37E-30
THYM	Epifactor	RPSA	CXXC1	0.818815915	1.05E-30
THYM	Epifactor	RPSA	NOC2L	0.822332774	3.62E-31
THYM	Epifactor	RPSA	TRIM28	0.824193438	2.04E-31
THYM	Epifactor	RPSA	PPP4C	0.829629548	3.68E-32
THYM	Epifactor	RPSA	TFPT	0.833300557	1.12E-32
THYM	Epifactor	RPSA	MBD3	0.83331482	1.11E-32
THYM	Epifactor	RPSA	RUVBL2	0.834355106	7.91E-33
THYM	Epifactor	RPSA	SS18L2	0.83802429	2.32E-33
THYM	Epifactor	RPSA	DMAP1	0.838663462	1.86E-33
THYM	Epifactor	RPSA	TAF10	0.844569646	2.39E-34
THYM	Epifactor	RPSA	FBL	0.848449831	5.93E-35
THYM	Epifactor	RPSA	BRMS1	0.84853088	5.76E-35
THYM	IUPHAR	RPSA	IMPDH2	0.803927744	7.45E-29
THYM	IUPHAR	RPSA	MFSD2B	0.805365617	5.02E-29
THYM	IUPHAR	RPSA	BAP1	0.808049818	2.38E-29
THYM	IUPHAR	RPSA	TRIM28	0.824193438	2.04E-31
THYM	IUPHAR	RPSA	MVD	0.838575191	1.92E-33
THYM	IUPHAR	RPSA	TWF2	0.839367581	1.47E-33
THYM	IUPHAR	RPSA	SLC27A5	0.849011	4.83E-35
THYM	IUPHAR	RPSA	SLC25A38	0.852672739	1.24E-35
THYM	Kinase	RPSA	TRIM28	0.824193438	2.04E-31
THYM	TF	RPSA	THAP3	0.811377339	9.26E-30
THYM	TF	RPSA	ZNF428	0.812199533	7.31E-30
THYM	TF	RPSA	CXXC1	0.818815915	1.05E-30
THYM	TF	RPSA	ZNF444	0.823294644	2.70E-31
THYM	TF	RPSA	THYN1	0.827984007	6.23E-32
THYM	TF	RPSA	MBD3	0.83331482	1.11E-32
THYM	TSG	RPSA	PFN1	0.8012736	1.53E-28
THYM	TSG	RPSA	BAP1	0.808049818	2.38E-29
THYM	TSG	RPSA	NPRL2	0.817459573	1.57E-30
THYM	TSG	RPSA	BRMS1	0.84853088	5.76E-35
THYM	TSG	RPSA	TSSC4	0.859711903	8.20E-37
THYM	TSG	RPSA	AIP	0.869548323	1.42E-38
THYM	TSG	RPSA	GNB2L1	0.870716369	8.58E-39
THYM	TSG	RPSA	GLTSCR2	0.878239878	2.97E-40
UCS	Cell metabolism gene	RPSA	APRT	0.800014314	2.15E-28
UCS	Cell metabolism gene	RPSA	IMPDH2	0.803927744	7.45E-29
UCS	Cell metabolism gene	RPSA	PSMB3	0.8086633	2.00E-29
UCS	Cell metabolism gene	RPSA	PGLS	0.812190088	7.33E-30
UCS	Cell metabolism gene	RPSA	PFDN5	0.815511181	2.79E-30
UCS	Cell metabolism gene	RPSA	MTMR14	0.817637271	1.49E-30
UCS	Cell metabolism gene	RPSA	POLA2	0.8227409	3.20E-31
UCS	Cell metabolism gene	RPSA	PSMB7	0.824387906	1.92E-31
UCS	Cell metabolism gene	RPSA	SSR2	0.827086364	8.27E-32
UCS	Cell metabolism gene	RPSA	TALDO1	0.834535051	7.45E-33
UCS	Cell metabolism gene	RPSA	TIMM13	0.835672273	5.11E-33
UCS	Cell metabolism gene	RPSA	MVD	0.838575191	1.92E-33
UCS	Cell metabolism gene	RPSA	LSM2	0.839098309	1.61E-33
UCS	Cell metabolism gene	RPSA	POLD2	0.840022742	1.17E-33
UCS	Cell metabolism gene	RPSA	ACOT8	0.843207902	3.87E-34
UCS	Cell metabolism gene	RPSA	TIMM8B	0.845818659	1.53E-34
UCS	Cell metabolism gene	RPSA	FPGS	0.846082822	1.40E-34
UCS	Cell metabolism gene	RPSA	SLC27A5	0.849011	4.83E-35
UCS	Cell metabolism gene	RPSA	PSMD13	0.850759107	2.54E-35
UCS	Cell metabolism gene	RPSA	SNRPD2	0.864013392	1.45E-37
UCS	Cell metabolism gene	RPSA	PSMC3	0.870082842	1.13E-38
UCS	Cell metabolism gene	RPSA	FAU	0.901429227	1.89E-45
UCS	CGC	RPSA	BAP1	0.808049818	2.38E-29
UCS	CGC	RPSA	TFPT	0.833300557	1.12E-32
UCS	CGC	RPSA	SDHAF2	0.847453822	8.52E-35
UCS	CGC	RPSA	RBM10	0.864823507	1.04E-37
UCS	Epifactor	RPSA	RRP8	0.800191828	2.05E-28
UCS	Epifactor	RPSA	CCDC101	0.800728277	1.78E-28
UCS	Epifactor	RPSA	BAP1	0.808049818	2.38E-29
UCS	Epifactor	RPSA	C17orf49	0.809842682	1.43E-29
UCS	Epifactor	RPSA	PRPF31	0.817932621	1.37E-30
UCS	Epifactor	RPSA	CXXC1	0.818815915	1.05E-30
UCS	Epifactor	RPSA	NOC2L	0.822332774	3.62E-31
UCS	Epifactor	RPSA	TRIM28	0.824193438	2.04E-31
UCS	Epifactor	RPSA	PPP4C	0.829629548	3.68E-32
UCS	Epifactor	RPSA	TFPT	0.833300557	1.12E-32
UCS	Epifactor	RPSA	MBD3	0.83331482	1.11E-32
UCS	Epifactor	RPSA	RUVBL2	0.834355106	7.91E-33
UCS	Epifactor	RPSA	SS18L2	0.83802429	2.32E-33
UCS	Epifactor	RPSA	DMAP1	0.838663462	1.86E-33
UCS	Epifactor	RPSA	TAF10	0.844569646	2.39E-34
UCS	Epifactor	RPSA	FBL	0.848449831	5.93E-35
UCS	Epifactor	RPSA	BRMS1	0.84853088	5.76E-35
UCS	IUPHAR	RPSA	IMPDH2	0.803927744	7.45E-29
UCS	IUPHAR	RPSA	MFSD2B	0.805365617	5.02E-29
UCS	IUPHAR	RPSA	BAP1	0.808049818	2.38E-29
UCS	IUPHAR	RPSA	TRIM28	0.824193438	2.04E-31
UCS	IUPHAR	RPSA	MVD	0.838575191	1.92E-33
UCS	IUPHAR	RPSA	TWF2	0.839367581	1.47E-33
UCS	IUPHAR	RPSA	SLC27A5	0.849011	4.83E-35
UCS	IUPHAR	RPSA	SLC25A38	0.852672739	1.24E-35
UCS	Kinase	RPSA	TRIM28	0.824193438	2.04E-31
UCS	TF	RPSA	THAP3	0.811377339	9.26E-30
UCS	TF	RPSA	ZNF428	0.812199533	7.31E-30
UCS	TF	RPSA	CXXC1	0.818815915	1.05E-30
UCS	TF	RPSA	ZNF444	0.823294644	2.70E-31
UCS	TF	RPSA	THYN1	0.827984007	6.23E-32
UCS	TF	RPSA	MBD3	0.83331482	1.11E-32
UCS	TSG	RPSA	PFN1	0.8012736	1.53E-28
UCS	TSG	RPSA	BAP1	0.808049818	2.38E-29
UCS	TSG	RPSA	NPRL2	0.817459573	1.57E-30
UCS	TSG	RPSA	BRMS1	0.84853088	5.76E-35
UCS	TSG	RPSA	TSSC4	0.859711903	8.20E-37
UCS	TSG	RPSA	AIP	0.869548323	1.42E-38
UCS	TSG	RPSA	GNB2L1	0.870716369	8.58E-39
UCS	TSG	RPSA	GLTSCR2	0.878239878	2.97E-40
UVM	Cell metabolism gene	RPSA	LTA4H	0.842368762	1.21E-22
UVM	IUPHAR	RPSA	LTA4H	0.842368762	1.21E-22
UVM	TSG	RPSA	ST13	0.824437169	5.66E-21

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRP	RPSA	RPL18A	-1.51651392808885	0.00016188295558095
KICH	RPSA	RPS27A	1.75396693785956	0.000187873840332031
KIRP	RPSA	RPS16	-1.35957043617517	0.00019507110118866
STAD	RPSA	RPS23	1.85076760664576	0.000364991836249828
COAD	RPSA	RPS3	1.48730375143014	0.000411599874496461
KIRP	RPSA	RPS11	-1.01861570565103	0.00105937570333481
LIHC	RPSA	RPL8	-4.84588284974558	0.00110314154326131
PRAD	RPSA	RPL18A	1.40600175748499	0.00205137828390396
KICH	RPSA	RPL19	1.36901182894089	0.00250792503356934
KICH	RPSA	RPS12	1.26997381758431	0.00308787822723389
LUAD	RPSA	RPL19	-1.31398026615725	0.00993159558412698
THCA	RPSA	RPS16	-6.16322798156577	0.0115764821363307
LUSC	RPSA	RPS23	1.46751169891047	0.0174932185880974
BLCA	RPSA	RPS12	-1.47804673440421	0.0204124450683594
BLCA	RPSA	RPS27A	-1.04747470069188	0.0258216857910156
HNSC	RPSA	RPS3	-4.73505819095135	0.0273726439852453
COAD	RPSA	RPS11	1.35307548998204	0.0312207043170929
LUSC	RPSA	RPL19	-2.14669889516666	0.044366810398747
UCEC	RPSA	RPS23	-2.03658159814007	0.046875
KIRC	RPSA	RPL19	-2.73485271276676	1.33980982873695e-10
BRCA	RPSA	RPS12	-4.91239327478244	1.85340619742495e-09
KIRC	RPSA	RPL35	-1.06475238059392	2.72286325678163e-08
KIRC	RPSA	RPL8	-1.18252459971773	5.64962994208288e-07
KIRP	RPSA	RPL8	-1.53003692350119	6.0301274061203e-05
KIRC	RPSA	RPS16	-1.66149869889384	7.8509870430991e-09
BRCA	RPSA	RPS27A	-4.28512148200424	7.8788217967112e-14
KIRP	RPSA	RPL35	-1.52981101975496	9.0546440333128e-05
KIRC	RPSA	RPS3	-1.29560847926387	9.05905681935088e-10
KIRC	RPSA	RPL18A	-4.43079304960843	9.2516163152192e-11

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPSA

CBX5, RPS21, TRIB3, CD4, HDAC5, PCNA, CLEC4G, VHL, SIRT7, KARS, NEDD4, TINF2, ACD, POT1, CUL1, COPS5, CAND1, PPP2R1A, APEX1, RPL5, RPL7, RPS3A, RPS6, RPS4X, RPLP0, RPL10A, RPL10, RPL11, RPL12, RPL13, RPL14, RPL18A, RPL18, RPL19, RPL23, RPL24, RPL27, RPL30, RPL31, RPL37A, RPL3, RPL4, RPL6, RPL7A, RPL8, RPS15A, RPS15, RPS16, RPS17, RPS23, RPS24, RPS25, RPS28, RPS3, RPS5, RPS8, RPL21, RPS2, RPLP1, RPL9, RPS26, RPL15, RPS20, RPL23A, RPLP2, RPL22, RPS14, RPS13, RPS7, RPS10, RPS19, RPS9, RPL35, RPL17, RPL29, RPL32, RPS27A, RPS29, EEF1A1, HNRNPA1, EIF4A1, PABPC1, HNRNPM, NHP2L1, SLC25A5, DHX9, HSPA5, SSR4, SLC25A4, RPN1, VDAC2, RBM8A, DKC1, PDHB, TCP1, RPLP0P6, CCT4, RPS27L, NENF, CLTC, CCT6A, ECE1, HSPA4, RPL10L, HIST1H2AA, RBMX, CCDC68, HNRNPA0, ESR1, CTNNB1, HSP90AA1, HSP90AB1, FN1, VCAM1, TP63, IL7R, RNF8, BRCA1, UBL4A, ITGA4, NKX3-1, BAG3, ANKH, C6orf106, SLC2A5, ACADVL, ABCD1, CALM2, HBG2, PROS1, DCTN6, GNMT, RNF114, HNRNPD, TARDBP, DYNC1LI2, DYNLL1, FAU, GNB2L1, PRUNE2, PTBP1, RPS12, RPS18, SYNCRIP, TSR1, XRCC6, rev, SUP35, ZBTB1, CUL7, OBSL1, RNF2, LUZP4, WDR76, FBXW11, HIST1H1A, LARP7, RPL26L1, RPSAP58, U2SURP, SF3B1, SF3B2, ZNF768, ZNF574, ZNF121, ZNF358, ZNF146, ZNF629, KRI1, LTV1, UTP23, DHX57, BMS1, ZNF777, CDR2L, CHERP, KRR1, ZBTB11, ZCRB1, CDR2, IMP3, GZF1, SRSF10, PURB, ZNF335, HSPB1, EIF4A2, LAGE3, RPL13A, RPL35A, RPL38, LOC101929876, RPS27, EEF1A2, PNO1, RPL27A, RPL34, RPL36, RPS11, UQCRC2, SFN, NTRK1, EWSR1, XPO1, HNRNPU, NPM1, LIMA1, Eif3a, Eif3e, Dctn3, Osgep, Rpl35, Rrbp1, Sesn2, GAN, MCM2, CDC73, CRBN, ZNF746, RRS1, YBX1, SLC9A1, CYLD, SPTA1, TRIM25, CCND2, PRNP, HDAC6, EIF4G2, PSMD1, SNAPC1, FBXO7, WDR77, HDAC4, YAF2, UBE2M, PRPF8, EFTUD2, AAR2, PIH1D1, TNIP2, CHD3, CHD4, RIOK1, ESR2, HEXIM1, MEPCE, SNAI1, RECQL4, GPC1, REST, MYC, Prkaa1, KRT17, METTL14, KIAA1429, RC3H1, RC3H2, ATG16L1, PSMA3, ACTC1, PHB, FAF1, NR2C2, PPP1CC, ZDHHC18, ZDHHC23, ATXN3, SNRNP70, ITFG1, HMGB1, PPP1CA, BIRC3, WWP2, LRRK2, CCDC13, ARIH2, PINK1, YAP1, TFCP2, FANCD2, NGB, E6, PEA15, LINC01554, ZC3H18, MAP2K3, RIPK1, MAU2, NEK4, LRRC31, DUX4, CIT, ANLN, CHMP4B, ECT2, KIF14, KIF20A, PRC1, MKI67, LRRC59, INS, NDN, AIMP2, MAFB, BRD4, NUPR1, CIC, Apc2, RBM39, LGALS9, IFI16, RIN3, DDX42, CTTN, CPSF7, NSRP1, PSPC1, YY1, PPP1R10, PPIL4, CCNT1, CDK9, LRPAP1, NUDT21, NUFIP2, PDIA6, EIF5A, GLUD1, TOP1, PIP4K2A, SART1, RCL1, RBM25, CSNK1D, C1orf35, OGT, SPOP, PARK2, UFL1, DDRGK1, FZR1, TSC2, WDR5, MAP4K3, NAA40, BGLT3, NGDN, WDR74, FTSJ3, CTCF, NAT10, SURF6, EPB41L5, UTP3, MPHOSPH10, SMURF2, AATF, GLYR1, STAU2, HIST1H2AG, PAK1IP1, DHX36, RRP12, NOP10, SREK1, PAPD5, DDX27, SSB, SRSF5, LIN28A, TTF1, ZNF16, PPAN-P2RY11, DDX31, DDX10, ZC3H8, LARP1B, FAM111B, NKRF, METTL17, YTHDF1, LARP1, PURA, GAR1, NOP16, SF3B5, RPL26, ZNF512, OASL, MAK16, GLTSCR2, RPL7L1, NOL10, PRDM15, POP1, RPS4Y2, GTPBP4, RSBN1, RSL1D1, CCDC137, HTRA4, ZC3HAV1, DHX30, NOL12, PRKRIR, NIFK, BTF3, EIF3E, Htatsf1, Pard6g, NLRP7, E, nsp1, nsp10, nsp4, ORF10, ORF7b, ORF8, nsp6, S, FGD5, RCHY1, CCNF, NBR1, TAX1BP1, CALCOCO2, PDE4B, SP1, TLX1,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
RPSA	chr3	39449137	T	C	single_nucleotide_variant	Benign	Asplenia,_isolated_congenital\|not_specified	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
RPSA	chr3	39449169	C	T	single_nucleotide_variant	Pathogenic	Asplenia,_isolated_congenital	SO:0001587\|nonsense	SO:0001587\|nonsense
RPSA	chr3	39449244	A	G	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPSA	chr3	39450065	C	T	single_nucleotide_variant	Benign	Asplenia,_isolated_congenital	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPSA	chr3	39450124	C	A	single_nucleotide_variant	Pathogenic	Asplenia,_isolated_congenital	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPSA	chr3	39450124	C	G	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPSA	chr3	39450135	C	T	single_nucleotide_variant	Pathogenic	Asplenia,_isolated_congenital	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPSA	chr3	39450232	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001575\|splice_donor_variant,SO:0001627\|intron_variant	SO:0001575\|splice_donor_variant,SO:0001627\|intron_variant
RPSA	chr3	39452307	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPSA	chr3	39452493	A	C	single_nucleotide_variant	Uncertain_significance	not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPSA	chr3	39452498	T	A	single_nucleotide_variant	Uncertain_significance	Asplenia,_isolated_congenital	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPSA	chr3	39453160	G	A	single_nucleotide_variant	Benign	Asplenia,_isolated_congenital\|not_specified\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPSA	chr3	39453179	C	G	single_nucleotide_variant	Pathogenic	Asplenia,_isolated_congenital	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPSA	chr3	39453179	C	T	single_nucleotide_variant	Pathogenic	Asplenia,_isolated_congenital	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPSA	chr3	39453197	C	T	single_nucleotide_variant	Pathogenic	Asplenia,_isolated_congenital	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPSA	chr3	39453229	G	GGTCAT	Duplication	Pathogenic	Asplenia,_isolated_congenital	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
RPSA	chr3	39453278	T	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPSA	chr3	39453367	C	CT	Duplication	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPSA	GBM	chr19	24010294	24010294	C	G	Missense_Mutation	p.Q111E	8
RPSA	PCPG	chr3	39453515	39453515	A	G	Silent		4
RPSA	PAAD	chr3	39450202	39450202	G	T	Missense_Mutation	p.R80M	3
RPSA	BRCA	chr3	39452384	39452384	A	C	Missense_Mutation	p.H131P	3
RPSA	UCS	chr3	39449160	39449160	G	A	Missense_Mutation	p.D6N	3
RPSA	STAD	chr3	39453198	39453198	G	A	Missense_Mutation	p.R186H	2
RPSA	KIRP	chr3	39453553	39453556	GTAT	-	Frame_Shift_Del	p.265_265del	2
RPSA	PAAD	chr3	39453425	39453425	G	A	Silent	p.V222V	2
RPSA	PRAD	chr3	39450137	39450137	T	G	Silent	p.L58L	2
RPSA	UCEC	chr3	39453434	39453434	G	T	Missense_Mutation	p.E225D	2
RPSA	UCEC	chr3	39453847	39453847	T	C	Silent	p.T292	2
RPSA	SKCM	chr3	39449165	39449165	C	T	Silent	p.V7V	2
RPSA	SKCM	chr3	39449166	39449166	C	T	Silent	p.L8L	2
RPSA	SKCM	chr3	39449176	39449176	A	G	Missense_Mutation	p.K11R	2
RPSA	PAAD	chr3	39453425	39453425	G	A	Silent		1
RPSA	BLCA	chr3	39453486	39453486	C	T	Missense_Mutation		1
RPSA	SKCM	chr3	39452312	39452312	C	G	Missense_Mutation	p.T107S	1
RPSA	GBM	chr19	24010412	24010412	C	A	Missense_Mutation	p.T150K	1
RPSA	PAAD	chr3	39450202	39450202	G	T	Missense_Mutation		1
RPSA	BLCA	chr3	39453526	39453526	C	T	Missense_Mutation		1
RPSA	GBM	chr3	39450122	39450122	G	A	Silent		1
RPSA	BLCA	chr3	39450193	39450193	T	C	Missense_Mutation	p.I77T	1
RPSA	STAD	chr3	39453212	39453212	C	T	Missense_Mutation	p.R191C	1
RPSA	BLCA	chr3	39453486	39453486	C	T	Missense_Mutation	p.P243S	1
RPSA	STAD	chr3	39452430	39452430	G	A	Silent	p.A146A	1
RPSA	KIRP	chr3	39453553	39453556	GTAT	-	Splice_Site	p.E270_splice	1
RPSA	BLCA	chr3	39453498	39453498	G	T	Missense_Mutation	p.D247Y	1
RPSA	STAD	chr3	39449253	39449253	T	C	Missense_Mutation	p.Y37H	1
RPSA	LGG	chr3	39448204	39448204	C	T	Splice_Site	.	1
RPSA	BLCA	chr3	39453526	39453526	C	T	Missense_Mutation	p.S256F	1
RPSA	UCEC	chr3	39453847	39453847	T	C	Silent	p.T297T	1
RPSA	LIHC	chr3	39453157	39453157	T	C	Silent	p.G172G	1
RPSA	SARC	chr3	39453160	39453160	G	A	Silent		1
RPSA	LIHC	chr3	39452291	39452291	C	-	Frame_Shift_Del	p.A100fs	1
RPSA	SARC	chr3	39449826	39449826	G	A	RNA	NULL	1
RPSA	CESC	chr3	39449223	39449223	G	A	Missense_Mutation		1
RPSA	LUAD	chr3	39449255	39449255	C	T	Silent	p.Y37Y	1
RPSA	ESCA	chr3	39452477	39452477	C	A	Missense_Mutation	p.P162Q	1
RPSA	UCS	chr3	39449160	39449160	G	A	Missense_Mutation		1
RPSA	LUAD	chr3	39453811	39453811	C	T	Silent	p.P280P	1
RPSA	LUAD	chr3	39452305	39452305	C	A	Missense_Mutation	p.P105T	1
RPSA	BLCA	chr3	39450193	39450193	T	C	Missense_Mutation		1
RPSA	GBM	chr19	24010322	24010322	G	A	Missense_Mutation	p.R120Q	1

Copy number variation (CNV) of RPSA
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RPSA
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
78208	ESCA	TCGA-VR-A8EQ	GTF2IRD1	chr7	73868506	+	RPSA	chr3	39450096	+
78208	N/A	EC570254	RBFOX2	chr22	36404899	-	RPSA	chr3	39453429	+
98309	N/A	BG033899	RPSA	chr3	39453803	+	LINC00593	chr15	69993751	-
96707	N/A	BP281426	RPSA	chr3	39452315	+	PXK	chr3	58376366	+
79205	UCEC	TCGA-AP-A05H-01A	RPSA	chr3	39450215	+	WIBG	chr12	56308150	-
78213	N/A	BM014604	RPSAP58	chr19	24010795	+	RPSA	chr3	39449111	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
TGCT	RPSA	0.000760166067408325	0.021
KIRC	RPSA	9.97359134933862e-07	2.8e-05

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
BRCA	RPSA	0.00613186418593539	0.2
PAAD	RPSA	0.011621126493801	0.37
THYM	RPSA	0.0133090946884874	0.41

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
P08865	DB04985	Tigapotide		Biotech	Investigational
P08865	DB04985	Tigapotide

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0152013	Adenocarcinoma of lung (disorder)	1	CTD_human
C0685889	Splenic Hypoplasia	1	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT