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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: MTIF2 (NCBI Gene ID:4528)

Gene Summary

Gene Summary

Gene Information	Gene Name: MTIF2
	Gene ID: 4528
	Gene Symbol	MTIF2
	Gene ID	4528
	Gene Name	mitochondrial translational initiation factor 2
	Synonyms	-
	Cytomap	2p16.1
	Type of Gene	protein-coding
	Description	translation initiation factor IF-2, mitochondrialIF-2mt
	Modification date	20200313
	UniProtAcc	P46199

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0032543	Mitochondrial translation
GO:0008135	Translation factor activity, RNA binding
GO:0006413	Translational initiation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
MTIF2	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'MTIF2[title] AND translation [title] AND human.'

Gene	Title	PMID
MTIF2	The human mitochondrial translation initiation factor 2 gene (MTIF2): transcriptional analysis and identification of a pseudogene	12932832

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000263629	55464423	55464564	In-frame
ENST00000394600	55464423	55464564	In-frame
ENST00000403721	55464423	55464564	In-frame
ENST00000263629	55470075	55470216	In-frame
ENST00000394600	55470075	55470216	In-frame
ENST00000403721	55470075	55470216	In-frame
ENST00000263629	55473472	55473597	Frame-shift
ENST00000394600	55473472	55473597	Frame-shift
ENST00000403721	55473472	55473597	Frame-shift
ENST00000263629	55479612	55479789	In-frame
ENST00000394600	55479612	55479789	In-frame
ENST00000403721	55479612	55479789	In-frame
ENST00000263629	55481176	55481337	Frame-shift
ENST00000394600	55481176	55481337	Frame-shift
ENST00000403721	55481176	55481337	Frame-shift
ENST00000263629	55481789	55481961	Frame-shift
ENST00000394600	55481789	55481961	Frame-shift
ENST00000403721	55481789	55481961	Frame-shift
ENST00000263629	55490775	55491001	3UTR-3CDS
ENST00000403721	55490775	55491001	3UTR-3CDS
ENST00000394600	55493516	55493654	3UTR-3UTR
ENST00000263629	55494704	55494771	3UTR-3UTR
ENST00000394600	55494704	55494771	3UTR-3UTR
ENST00000263629	55495713	55495875	3UTR-3UTR
ENST00000394600	55495713	55495875	3UTR-3UTR

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000403721	55464423	55464564	2403	2020	2160	727	623	670
ENST00000263629	55464423	55464564	2545	2187	2327	727	623	670
ENST00000394600	55464423	55464564	2964	2608	2748	727	623	670
ENST00000403721	55470075	55470216	2403	1714	1854	727	521	568
ENST00000263629	55470075	55470216	2545	1881	2021	727	521	568
ENST00000394600	55470075	55470216	2964	2302	2442	727	521	568
ENST00000403721	55479612	55479789	2403	814	990	727	221	280
ENST00000263629	55479612	55479789	2545	981	1157	727	221	280
ENST00000394600	55479612	55479789	2964	1402	1578	727	221	280

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
P46199	623	670	30	727	Chain	ID=PRO_0000014480;Note=Translation initiation factor IF-2%2C mitochondrial
P46199	521	568	30	727	Chain	ID=PRO_0000014480;Note=Translation initiation factor IF-2%2C mitochondrial
P46199	221	280	30	727	Chain	ID=PRO_0000014480;Note=Translation initiation factor IF-2%2C mitochondrial
P46199	623	670	30	727	Chain	ID=PRO_0000014480;Note=Translation initiation factor IF-2%2C mitochondrial
P46199	521	568	30	727	Chain	ID=PRO_0000014480;Note=Translation initiation factor IF-2%2C mitochondrial
P46199	221	280	30	727	Chain	ID=PRO_0000014480;Note=Translation initiation factor IF-2%2C mitochondrial
P46199	623	670	30	727	Chain	ID=PRO_0000014480;Note=Translation initiation factor IF-2%2C mitochondrial
P46199	521	568	30	727	Chain	ID=PRO_0000014480;Note=Translation initiation factor IF-2%2C mitochondrial
P46199	221	280	30	727	Chain	ID=PRO_0000014480;Note=Translation initiation factor IF-2%2C mitochondrial
P46199	221	280	178	348	Domain	Note=tr-type G
P46199	221	280	178	348	Domain	Note=tr-type G
P46199	221	280	178	348	Domain	Note=tr-type G
P46199	221	280	234	237	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000250;evidence=ECO:0000250
P46199	221	280	234	237	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000250;evidence=ECO:0000250
P46199	221	280	234	237	Nucleotide binding	Note=GTP;Ontology_term=ECO:0000250;evidence=ECO:0000250
P46199	221	280	234	237	Region	Note=G3;Ontology_term=ECO:0000250;evidence=ECO:0000250
P46199	221	280	234	237	Region	Note=G3;Ontology_term=ECO:0000250;evidence=ECO:0000250
P46199	221	280	234	237	Region	Note=G3;Ontology_term=ECO:0000250;evidence=ECO:0000250
P46199	521	568	556	556	Natural variant	ID=VAR_014883;Note=V->I;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:12932832,ECO:0000269\|PubMed:7829522;Dbxref=dbSNP:rs11357,PMID:12932832,PMID:7829522
P46199	521	568	556	556	Natural variant	ID=VAR_014883;Note=V->I;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:12932832,ECO:0000269\|PubMed:7829522;Dbxref=dbSNP:rs11357,PMID:12932832,PMID:7829522
P46199	521	568	556	556	Natural variant	ID=VAR_014883;Note=V->I;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:12932832,ECO:0000269\|PubMed:7829522;Dbxref=dbSNP:rs11357,PMID:12932832,PMID:7829522

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
STAD	MTIF2	-1.91099017365555	0.000110303983092308
PRAD	MTIF2	-2.91163945232732	0.000148819683073472
THCA	MTIF2	1.01909960064239	0.00052377205169468
KIRC	MTIF2	-1.30575511475086	0.0182888755834972
LUAD	MTIF2	-5.14356588709714	3.996080695583e-11

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
LGG	MTIF2	-0.069477883	0.007305531

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with MTIF2 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
UVM	Cell metabolism gene	MTIF2	HSPD1	0.801908189	3.97E-19
UVM	Cell metabolism gene	MTIF2	GNPNAT1	0.812100866	6.23E-20
UVM	Cell metabolism gene	MTIF2	PMPCB	0.826902513	3.43E-21
UVM	CGC	MTIF2	DDX10	0.80029522	5.27E-19
UVM	CGC	MTIF2	CUL3	0.800395887	5.18E-19
UVM	CGC	MTIF2	RAD17	0.806001649	1.91E-19
UVM	CGC	MTIF2	PALB2	0.826292267	3.88E-21
UVM	CGC	MTIF2	MSH2	0.82829427	2.57E-21
UVM	CGC	MTIF2	CCDC6	0.835349855	5.77E-22
UVM	Epifactor	MTIF2	PHF14	0.800173624	5.38E-19
UVM	Epifactor	MTIF2	CUL3	0.800395887	5.18E-19
UVM	Epifactor	MTIF2	BRCC3	0.801321755	4.40E-19
UVM	Epifactor	MTIF2	ZRANB3	0.816255007	2.83E-20
UVM	Epifactor	MTIF2	TLK1	0.825802975	4.29E-21
UVM	Epifactor	MTIF2	CUL2	0.835314871	5.82E-22
UVM	Epifactor	MTIF2	DDX50	0.838240257	3.07E-22
UVM	Epifactor	MTIF2	FAM175B	0.854526485	6.77E-24
UVM	IUPHAR	MTIF2	SLC30A5	0.806251138	1.83E-19
UVM	IUPHAR	MTIF2	CSNK1G3	0.812605521	5.67E-20
UVM	IUPHAR	MTIF2	RIOK2	0.812676385	5.59E-20
UVM	IUPHAR	MTIF2	METAP2	0.820383067	1.27E-20
UVM	IUPHAR	MTIF2	TLK1	0.825802975	4.29E-21
UVM	Kinase	MTIF2	CSNK1G3	0.812605521	5.67E-20
UVM	Kinase	MTIF2	RIOK2	0.812676385	5.59E-20
UVM	Kinase	MTIF2	TLK1	0.825802975	4.29E-21
UVM	TF	MTIF2	ZNF320	0.801878141	3.99E-19
UVM	TF	MTIF2	ZNF37A	0.80406243	2.71E-19
UVM	TF	MTIF2	ZNF131	0.825978291	4.14E-21
UVM	TF	MTIF2	ZNF277	0.828139442	2.66E-21
UVM	TF	MTIF2	CEBPZ	0.829247113	2.11E-21
UVM	TF	MTIF2	GPBP1	0.83203837	1.17E-21
UVM	TF	MTIF2	ZNF146	0.834369136	7.13E-22
UVM	TF	MTIF2	ZC3H8	0.847637642	3.58E-23
UVM	TSG	MTIF2	HSPD1	0.801908189	3.97E-19
UVM	TSG	MTIF2	DCLRE1A	0.802410239	3.63E-19
UVM	TSG	MTIF2	COPS2	0.802558564	3.54E-19
UVM	TSG	MTIF2	PALB2	0.826292267	3.88E-21
UVM	TSG	MTIF2	MSH2	0.82829427	2.57E-21
UVM	TSG	MTIF2	CUL2	0.835314871	5.82E-22

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
COAD	MTIF2	MRPS12	2.11566333114824	0.000125885009765625
BRCA	MTIF2	MRPS15	-2.19567551682318	0.000188684660674703
KICH	MTIF2	MRPS5	1.25108287838437	0.000249803066253662
LIHC	MTIF2	MRPS7	1.27029395477208	0.00182077236082954
STAD	MTIF2	MRPS16	-1.64208084987431	0.00239070039242506
KIRC	MTIF2	MRPS15	1.11572283836012	0.00361818577801855
ESCA	MTIF2	MRPS12	-1.86248549814506	0.0048828125
PRAD	MTIF2	MRPS9	1.04379115553269	0.00496210155254694
HNSC	MTIF2	MRPS16	-2.01564621821803	0.00518989327406416
COAD	MTIF2	MTIF3	1.61088953830673	0.00561287999153138
CHOL	MTIF2	MRPS6	2.57097392409939	0.0078125
STAD	MTIF2	MTIF3	-1.25397254610668	0.0093395933508873
LUSC	MTIF2	MRPS6	-1.26158810839259	0.013873001943322
THCA	MTIF2	MRPS15	-1.19960602422995	0.0140154883942907
ESCA	MTIF2	MRPS5	-2.15440118747854	0.0185546875
HNSC	MTIF2	MRPS12	1.33677139927136	0.0248336488591576
THCA	MTIF2	MRPS11	-3.10694728540962	0.0252226935182201
BLCA	MTIF2	MRPS11	-2.30276998968219	0.040130615234375
LUAD	MTIF2	MRPS12	-5.3399185683719	1.00823612619819e-08
THCA	MTIF2	MRPS10	1.33413691764991	1.55171507174296e-05
BRCA	MTIF2	MRPS12	-1.59537235222597	1.66215672512325e-20
LUAD	MTIF2	MRPS5	-2.20881945885927	1.77904381378076e-06
LUSC	MTIF2	MRPS9	-3.60637641031661	1.82498668910368e-07
LUAD	MTIF2	MRPS9	-1.32894454884901	1.98978698949574e-05
BRCA	MTIF2	MRPS11	-1.24304977976804	2.31302509538916e-07
LIHC	MTIF2	MRPS12	2.67189430810317	2.56696988045444e-05
KICH	MTIF2	MRPS12	1.48941080926405	3.19480895996094e-05
PRAD	MTIF2	MRPS6	1.00673230965164	3.48152859299693e-07
LUSC	MTIF2	MRPS5	-7.65956389962319	4.27210217182982e-06
BRCA	MTIF2	MTIF3	-1.57382804516009	4.69602801583771e-07
KIRC	MTIF2	MRPS6	-3.12621933743663	4.95376546353503e-10
LUSC	MTIF2	MRPS11	-2.9004097541444	5.43966600483641e-07
LUSC	MTIF2	MTIF3	1.14980970601281	5.67568378344708e-05
KICH	MTIF2	MRPS6	-1.34376231922276	7.49826431274414e-05
BRCA	MTIF2	MRPS7	-2.12787460270434	9.33194208595055e-10

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with MTIF2

ALK, ICT1, DIRAS3, HSD17B8, ARHGEF26, DHRS4L2, NUDT6, PPA2, MRM1, NDUFA10, LDHAL6B, ACAA2, ECSIT, TTC39B, DAP3, MRPS11, OXLD1, HSPB1, TSC22D2, MRPL12, MRPL21, TSFM, NDUFS7, CLPB, TUFM, SUCLA2, YBEY, METTL2A, ATP5D, PDHX, FOXRED1, BPNT1, MTG2, TMEM70, RNMTL1, TRIM43, TRMT61B, AIFM1, HSPD1, PDK1, CHTOP, IMMP2L, HSCB, GRSF1, BRD1, ACAD9, AUH, C1QBP, C21orf33, C6orf203, MCUR1, CCDC90B, CRYZ, CS, DDX28, FASTKD3, FASTKD5, GFM1, HINT2, LRPPRC, CCDC109B, MDH2, METTL15, METTL17, MRPL11, MRPS12, MRPS26, MRRF, MTERF3, MTG1, AARS2, ABCB7, ACAT1, ACOT1, ACOT2, AFG3L2, AK4, ALAS1, ATP5B, ATP5J2-PTCD1, ATP5L, ATP5F1, ATP5H, ATP5J, ATP5O, ATPAF1, BCKDK, BCS1L, C17orf80, C7orf55-LUC7L2, CARS2, CDK5RAP1, CLPP, CLPX, CNP, COQ5, COX4I1, COX5A, DARS2, DBT, DHX30, DLAT, DLST, DNAJA3, ECHS1, ECI2, ELAC2, ERAL1, ETFA, ETFB, FASTKD2, FGA, GADD45GIP1, GARS, GATB, GATC, GCDH, GLS, GLUD1, GRPEL1, GTPBP10, GTPBP3, GTPBP6, GUF1, HADH, HADHA, HADHB, HARS2, HNRNPDL, HNRNPL, HSD17B10, HSDL2, HSPA9, IARS2, IBA57, KIAA0391, LARS2, LETM1, LONP1, LYPLAL1, LYRM4, ME2, MMAB, MUT, MRPL1, MRPL10, MRPL13, MRPL14, MRPL15, MRPL16, MRPL17, MRPL19, MRPL20, MRPL22, MRPL23, MRPL24, MRPL27, MRPL28, MRPL3, MRPL32, MRPL37, MRPL38, MRPL39, MRPL4, MRPL40, MRPL41, MRPL42, MRPL43, MRPL44, MRPL45, MRPL46, MRPL47, MRPL48, MRPL49, MRPL50, MRPL53, MRPL55, MRPL57, MRPL9, MRPS10, MRPS14, MRPS15, MRPS16, MRPS17, MRPS18A, MRPS18B, MRPS18C, MRPS2, MRPS21, MRPS22, MRPS23, MRPS24, MRPS25, MRPS27, MRPS28, MRPS30, MRPS31, MRPS33, MRPS34, MRPS35, MRPS36, MRPS5, MRPS6, MRPS7, MRPS9, MTHFD1L, MTHFD2, MTO1, MTPAP, MTRF1L, NDUFA12, NDUFA2, NDUFA5, NDUFA6, NDUFA7, NDUFA9, NDUFAB1, NDUFAF1, NDUFAF2, NDUFAF4, NDUFAF5, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS6, NDUFS8, NDUFV1, NDUFV2, NDUFV3, NFS1, NIPSNAP1, NME4, NNT, NOA1, NT5DC2, NUBPL, NUDT19, OAT, OGDH, OXA1L, PAM16, PDE12, PDHA1, PDHB, PDK3, PDPR, PNPLA8, PNPT1, POLDIP2, POLG, POLRMT, PPIF, PRDX3, PREPL, PTCD3, PUS1, PYCR1, PYCR2, QRSL1, RTN4IP1, SARS2, SDHA, SHMT2, SLC2A1, SLC30A9, SLIRP, STOML2, SUPV3L1, TACO1, TARS2, TEFM, TFAM, THEM4, TIMM44, TOP3A, TRMT10C, TRUB2, C10orf2, UQCC1, VARS2, VWA8, WARS2, YARS2, MTIF3, MTRF1, NGRN, OTC, PMPCA, PMPCB, RPUSD3, RPUSD4, SSBP1, SURF1, TBRG4, EXD2, ORF8b, DNAJC28, DDX58, COX8A, TRAP1, SMAD4, NIPSNAP3A, UQCRFS1, C22orf15, AGO2, PRKAA1, PTCD1, MALSU1, NUDT16, PFDN5, FTSJ2, NIPSNAP3B, SHC2, AMACR, FAHD1, CBR4, ZC3H3, DHRS2, RASL10B,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
MTIF2	chr2	55476602	GCTCTTTTTTCA	G	Deletion	Pathogenic	Inborn_genetic_diseases	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
MTIF2	chr2	55481268	G	C	single_nucleotide_variant	Pathogenic	Inborn_genetic_diseases	SO:0001583\|missense_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001627\|intron_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
MTIF2	CESC	chr2	55470638	55470638	C	T	Missense_Mutation	p.R493Q	6
MTIF2	LIHC	chr2	55489457	55489457	T	-	Frame_Shift_Del	p.N109fs	6
MTIF2	ESCA	chr2	55490859	55490859	C	T	Missense_Mutation	p.A46T	4
MTIF2	KIRP	chr2	55470636	55470636	A	G	Missense_Mutation	p.F494L	4
MTIF2	LIHC	chr2	55467250	55467250	T	-	Frame_Shift_Del	p.K589fs	4
MTIF2	LIHC	chr2	55481808	55481808	T	-	Frame_Shift_Del	p.N162fs	4
MTIF2	BRCA	chr2	55463924	55463924	C	T	Missense_Mutation	p.D682N	3
MTIF2	LIHC	chr2	55489517	55489517	T	-	Frame_Shift_Del	p.K89fs	3
MTIF2	LIHC	chr2	55467172	55467172	G	-	Frame_Shift_Del	p.P615fs	3
MTIF2	COAD	chr2	55467250	55467250	T	-	Frame_Shift_Del	p.G590fs	3
MTIF2	LIHC	chr2	55473534	55473534	C	T	Missense_Mutation		3
MTIF2	BLCA	chr2	55471167	55471167	C	G	Missense_Mutation	p.E437Q	3
MTIF2	UCEC	chr2	55481207	55481207	C	A	Missense_Mutation	p.G212C	3
MTIF2	BLCA	chr2	55476578	55476578	C	T	Missense_Mutation	p.E312K	3
MTIF2	LIHC	chr2	55473534	55473534	C	T	Missense_Mutation	p.A349T	3
MTIF2	UCEC	chr2	55470694	55470694	A	C	Missense_Mutation	p.H474Q	3
MTIF2	ESCA	chr2	55471307	55471307	C	G	Missense_Mutation	p.G390A	3
MTIF2	BRCA	chr2	55463838	55463840	AAC	-	In_Frame_Del	p.V710in_frame_del	3
MTIF2	STAD	chr2	55490777	55490777	T	-	Splice_Site	p.K73_splice	2
MTIF2	ESCA	chr2	55476622	55476622	G	T	Missense_Mutation	p.P297H	2
MTIF2	UCEC	chr2	55481925	55481925	T	C	Missense_Mutation	p.D123G	2
MTIF2	STAD	chr2	55491004	55491004	G	-	Splice_Site		2
MTIF2	LGG	chr2	55479696	55479696	T	C	Missense_Mutation	p.D253G	2
MTIF2	ESCA	chr2	55476628	55476628	G	A	Missense_Mutation	p.A295V	2
MTIF2	LIHC	chr2	55470647	55470647	G	-	Frame_Shift_Del	p.S490fs	2
MTIF2	UCEC	chr2	55490925	55490925	G	A	Silent	p.L24	2
MTIF2	ESCA	chr2	55489519	55489519	T	C	Silent		2
MTIF2	TGCT	chr2	55467244	55467244	T	A	Silent		2
MTIF2	UCEC	chr2	55464459	55464459	A	C	Missense_Mutation	p.F659C	2
MTIF2	BLCA	chr2	55479634	55479634	G	C	Missense_Mutation	p.Q274E	2
MTIF2	CESC	chr2	55481864	55481864	C	T	Silent		2
MTIF2	LIHC	chr2	55479663	55479663	C	A	Missense_Mutation	p.G264V	2
MTIF2	LGG	chr2	55479696	55479696	T	C	Missense_Mutation		2
MTIF2	UCEC	chr2	55467222	55467222	T	C	Missense_Mutation	p.I599V	2
MTIF2	BLCA	chr2	55464514	55464514	C	A	Missense_Mutation	p.V641F	2
MTIF2	CESC	chr2	55470693	55470693	G	T	Missense_Mutation		2
MTIF2	ESCA	chr2	55489519	55489519	T	C	Silent	p.K88K	2
MTIF2	STAD	chr2	55470795	55470795	G	A	Missense_Mutation	p.R441C	2
MTIF2	LUAD	chr2	55463886	55463886	G	A	Silent	p.L694L	2
MTIF2	TGCT	chr2	55479643	55479643	C	T	Missense_Mutation		2
MTIF2	SARC	chr2	55490819	55490819	G	T	Missense_Mutation		2
MTIF2	UCEC	chr2	55470612	55470612	G	A	Missense_Mutation	p.P502S	2
MTIF2	ESCA	chr2	55490950	55490950	G	T	Missense_Mutation	p.H15Q	2
MTIF2	CESC	chr2	55481288	55481288	T	C	Missense_Mutation		2
MTIF2	LIHC	chr2	55471327	55471327	T	-	Frame_Shift_Del	p.K383fs	2
MTIF2	STAD	chr2	55464532	55464532	T	G	Missense_Mutation	p.T635P	2
MTIF2	STAD	chr2	55476655	55476655	G	A	Missense_Mutation	p.A286V	2
MTIF2	KIRC	chr2	55464461	55464461	T	-	Frame_Shift_Del	p.F659fs	2
MTIF2	LUAD	chr2	55481241	55481241	A	C	Missense_Mutation	p.F200L	2
MTIF2	TGCT	chr2	55479643	55479643	C	T	Missense_Mutation	p.E271K	2
MTIF2	UCEC	chr2	55471182	55471182	G	T	Missense_Mutation	p.L432I	2
MTIF2	ESCA	chr2	55464537	55464537	G	T	Missense_Mutation	p.S633Y	2
MTIF2	CESC	chr2	55470638	55470638	C	T	Missense_Mutation		2
MTIF2	STAD	chr2	55476576	55476576	T	G	Missense_Mutation	p.E312D	2
MTIF2	STAD	chr2	55470699	55470699	C	T	Missense_Mutation	p.A473T	2
MTIF2	LUAD	chr2	55471275	55471275	C	G	Missense_Mutation	p.D401H	2
MTIF2	SKCM	chr2	55481241	55481241	A	G	Silent	p.F200F	2
MTIF2	UCEC	chr2	55471199	55471199	G	T	Missense_Mutation	p.S426Y	2
MTIF2	ESCA	chr2	55471307	55471307	C	G	Missense_Mutation		2
MTIF2	STAD	chr2	55467153	55467153	G	T	Missense_Mutation	p.P622T	2
MTIF2	LIHC	chr2	55467240	55467240	T	-	Frame_Shift_Del	p.I593fs	2
MTIF2	BLCA	chr2	55471167	55471167	C	G	Missense_Mutation		2
MTIF2	SKCM	chr2	55473528	55473528	G	A	Missense_Mutation	p.P351S	2
MTIF2	UCEC	chr2	55471286	55471286	C	T	Missense_Mutation	p.R397H	2
MTIF2	STAD	chr2	55464533	55464533	T	C	Silent	p.V634V	2
MTIF2	BLCA	chr2	55476578	55476578	C	T	Missense_Mutation		2
MTIF2	KIRP	chr2	55473595	55473595	G	A	Silent	p.G328G	2
MTIF2	LIHC	chr2	55479663	55479663	C	A	Missense_Mutation		2
MTIF2	UCEC	chr2	55471287	55471287	G	A	Missense_Mutation	p.R397C	2
MTIF2	ESCA	chr2	55476628	55476628	G	A	Missense_Mutation		2
MTIF2	ESCA	chr2	55470218	55470218	T	C	Splice_Site		2
MTIF2	SKCM	chr2	55467224	55467224	A	G	Missense_Mutation	p.I598T	2
MTIF2	UCEC	chr2	55479759	55479759	A	T	Missense_Mutation	p.F232Y	2
MTIF2	BRCA	chr2	55470655	55470655	C	T	Silent	p.K487	2
MTIF2	BLCA	chr2	55471226	55471226	C	T	Missense_Mutation	p.G417E	2
MTIF2	LIHC	chr2	55473549	55473549	T	-	Frame_Shift_Del	p.M344fs	2
MTIF2	UCEC	chr2	55479763	55479763	T	C	Missense_Mutation	p.T231A	2
MTIF2	BLCA	chr2	55473552	55473552	C	G	Missense_Mutation		1
MTIF2	CESC	chr2	55479767	55479767	C	C	Missense_Mutation		1
MTIF2	HNSC	chr2	55470800	55470800	C	A	Missense_Mutation		1
MTIF2	LIHC	chr2	55471260	55471260	T	-	Frame_Shift_Del	p.T406fs	1
MTIF2	KIRP	chr2	55473595	55473595	G	A	Silent		1
MTIF2	PRAD	chr2	55481258	55481258	T	C	Missense_Mutation	p.T195A	1
MTIF2	UCEC	chr2	55471287	55471287	G	T	Missense_Mutation	p.R397S	1
MTIF2	BLCA	chr2	55473543	55473543	C	T	Missense_Mutation	p.E346K	1
MTIF2	LIHC	chr2	55470681	55470681	C	A	Nonsense_Mutation	p.E479X	1
MTIF2	SKCM	chr2	55481309	55481309	G	A	Missense_Mutation	p.P178S	1
MTIF2	ESCA	chr2	55467284	55467284	G	A	Missense_Mutation		1
MTIF2	BLCA	chr2	55479634	55479634	G	C	Missense_Mutation		1
MTIF2	HNSC	chr2	55464538	55464538	A	T	Missense_Mutation		1
MTIF2	LIHC	chr2	55479772	55479772	C	-	Frame_Shift_Del	p.E228fs	1
MTIF2	PRAD	chr2	55489556	55489556	C	T	Missense_Mutation	p.G76E	1
MTIF2	UCEC	chr2	55467277	55467278	AT	-	Frame_Shift_Del	p.N580fs	1
MTIF2	BLCA	chr2	55473552	55473552	C	G	Missense_Mutation	p.E343Q	1
MTIF2	SKCM	chr2	55489532	55489532	G	T	Nonsense_Mutation	p.S84*	1
MTIF2	CESC	chr2	55481852	55481852	C	T	Missense_Mutation		1
MTIF2	BLCA	chr2	55464514	55464514	C	A	Missense_Mutation		1
MTIF2	COAD	chr2	55463835	55463835	A	C	Missense_Mutation	p.C711W	1
MTIF2	HNSC	chr2	55471317	55471317	G	A	Silent		1
MTIF2	LGG	chr2	55489563	55489563	C	T	Splice_Site	p.E74_splice	1
MTIF2	READ	chr2	55470626	55470626	C	A	Missense_Mutation	p.R497I	1
MTIF2	ESCA	chr2	55489519	55489519	T	C	Silent	p.K88	1
MTIF2	ESCA	chr2	55470218	55470218	T	C	Splice_Site	.	1
MTIF2	STAD	chr2	55464532	55464532	T	G	Missense_Mutation		1
MTIF2	STAD	chr2	55490842	55490842	C	T	Nonsense_Mutation	p.W51X	1
MTIF2	UCS	chr2	55463904	55463904	C	A	Silent	p.T688T	1
MTIF2	LUAD	chr2	55481789	55481789	C	A	Splice_Site		1
MTIF2	TGCT	chr2	55470115	55470115	C	T	Missense_Mutation		1
MTIF2	BLCA	chr2	55481222	55481222	C	G	Missense_Mutation		1
MTIF2	COAD	chr2	55467249	55467249	C	T	Missense_Mutation	p.G590R	1
MTIF2	HNSC	chr2	55464538	55464538	A	T	Missense_Mutation	p.S633T	1
MTIF2	READ	chr2	55473560	55473560	G	A	Missense_Mutation	p.A340V	1
MTIF2	STAD	chr2	55467250	55467250	T	C	Silent	p.K589K	1
MTIF2	HNSC	chr2	55471317	55471317	G	A	Silent	p.L387L	1
MTIF2	BLCA	chr2	55467162	55467162	C	T	Missense_Mutation		1
MTIF2	LIHC	chr2	55481322	55481322	T	A	Silent		1
MTIF2	BLCA	chr2	55481222	55481222	C	G	Missense_Mutation	p.A207P	1
MTIF2	BLCA	chr2	55470564	55470564	C	A	Missense_Mutation		1
MTIF2	COAD	chr2	55476540	55476540	G	A	Silent	p.S324S	1
MTIF2	LIHC	chr2	55470647	55470647	G	-	Frame_Shift_Del		1
MTIF2	SARC	chr2	55489529	55489529	G	T	Missense_Mutation	p.T85K	1
MTIF2	BLCA	chr2	55470564	55470564	C	A	Missense_Mutation	p.V518L	1
MTIF2	KIRP	chr2	55473542	55473542	T	G	Missense_Mutation	p.E346A	1
MTIF2	THCA	chr2	55470610	55470610	G	T	Silent		1
MTIF2	BLCA	chr2	55481208	55481208	T	G	Silent		1
MTIF2	COAD	chr2	55481261	55481261	T	-	Frame_Shift_Del	p.T194fs	1
MTIF2	LIHC	chr2	55463923	55463923	T	C	Missense_Mutation		1
MTIF2	BLCA	chr2	55481208	55481208	T	G	Silent	p.G211G	1
MTIF2	BLCA	chr2	55464537	55464537	G	C	Missense_Mutation		1
MTIF2	CESC	chr2	55481852	55481852	C	T	Missense_Mutation	p.M147I	1
MTIF2	LUAD	chr2	55481268	55481268	G	A	Silent	p.H191H	1
MTIF2	THYM	chr2	55479626	55479626	G	T	Silent		1
MTIF2	COAD	chr2	55490956	55490956	T	G	Silent	p.R13R	1
MTIF2	ESCA	chr2	55476622	55476622	G	T	Missense_Mutation		1
MTIF2	CESC	chr2	55481864	55481864	C	T	Silent	p.T143T	1
MTIF2	LUAD	chr2	55464460	55464461	-	T	Frame_Shift_Ins	p.N*658fs	1
MTIF2	UCEC	chr2	55470645	55470645	T	A	Missense_Mutation	p.I491F	1
MTIF2	BLCA	chr2	55463873	55463873	C	G	Missense_Mutation		1
MTIF2	DLBC	chr2	55470662	55470662	A	G	Missense_Mutation	p.L485P	1
MTIF2	SKCM	chr2	55489532	55489532	G	T	Nonsense_Mutation	p.S84X	1
MTIF2	BLCA	chr2	55463873	55463873	C	G	Missense_Mutation	p.D699H	1
MTIF2	STAD	chr2	55490845	55490845	G	T	Silent	p.A50A	1
MTIF2	BLCA	chr2	55471226	55471226	C	T	Missense_Mutation		1
MTIF2	CESC	chr2	55470693	55470693	G	T	Missense_Mutation	p.Q475K	1
MTIF2	KIRP	chr2	55467312	55467312	C	A	Splice_Site		1
MTIF2	LUSC	chr2	55490959	55490959	T	A	Silent	p.L12L	1
MTIF2	ESCA	chr2	55470218	55470218	T	C	Splice_Site	e10-2	1
MTIF2	ESCA	chr2	55490950	55490950	G	T	Missense_Mutation		1
MTIF2	STAD	chr2	55490842	55490842	C	T	Nonsense_Mutation	p.W51*	1
MTIF2	BLCA	chr2	55473543	55473543	C	T	Missense_Mutation		1
MTIF2	CESC	chr2	55481288	55481288	T	C	Missense_Mutation	p.I185V	1
MTIF2	ESCA	chr2	55476575	55476575	C	A	Missense_Mutation		1
MTIF2	LIHC	chr2	55470632	55470632	A	-	Frame_Shift_Del	p.L495fs	1
MTIF2	KIRP	chr2	55470636	55470636	A	G	Missense_Mutation		1
MTIF2	OV	chr2	55473531	55473531	C	A	Missense_Mutation	p.D350Y	1
MTIF2	SKCM	chr2	55467227	55467227	T	A	Missense_Mutation	p.K597I	1
MTIF2	ESCA	chr2	55490859	55490859	C	T	Missense_Mutation		1

Copy number variation (CNV) of MTIF2
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across MTIF2
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
78580	N/A	EC571383	ATP5J2-PTCD1	chr7	99057757	-	MTIF2	chr2	55481295	+
78580	N/A	AV693138	MAD1L1	chr7	1953360	+	MTIF2	chr2	55476641	-
72103	N/A	BF337241	MTIF2	chr2	55463756	-	ARHGAP8	chr22	45158444	-
96661	N/A	CB322028	MTIF2	chr2	55463925	+	GLUL	chr1	182353606	+
95643	N/A	AV686355	MTIF2	chr2	55471272	-	GNB1L	chr22	19823500	-
87227	LIHC	TCGA-CC-A3MB-01A	MTIF2	chr2	55489452	-	PPP3R1	chr2	68415822	-
102618	LUSC	TCGA-22-5492	MTIF2	chr2	55463769	-	RPS27A	chr2	55460499	+
102618	N/A	AA492364	MTIF2	chr2	55462564	-	RPS27A	chr2	55462743	-
102618	N/A	AA528259	MTIF2	chr2	55462564	-	RPS27A	chr2	55462741	-
102618	N/A	AA714961	MTIF2	chr2	55462593	-	RPS27A	chr2	55462749	-
102618	N/A	BG059465	MTIF2	chr2	55462564	-	RPS27A	chr2	55462745	-
102618	N/A	EC442375	MTIF2	chr2	55462732	-	RPS27A	chr2	55462730	-
80261	STAD	TCGA-D7-6822-01A	MTIF2	chr2	55489452	-	SMEK2	chr2	55842642	-
78580	N/A	AA658829	RPS27A	chr2	55462745	+	MTIF2	chr2	55462564	+
78580	N/A	AW023019	RPS27A	chr2	55462745	+	MTIF2	chr2	55462655	+
78580	N/A	BF244266	RPS27A	chr2	55462708	+	MTIF2	chr2	55462710	+
78580	N/A	BF246442	RPS27A	chr2	55462699	+	MTIF2	chr2	55462701	+
78580	N/A	BG033492	RPS27A	chr2	55462744	+	MTIF2	chr2	55462564	+
78580	N/A	BG575191	RPS27A	chr2	55462741	+	MTIF2	chr2	55462564	+
78580	N/A	CF122644	RPS27A	chr2	55462739	+	MTIF2	chr2	55462564	+
78580	N/A	CF123715	RPS27A	chr2	55462743	+	MTIF2	chr2	55462564	+
78580	N/A	CF124463	RPS27A	chr2	55462743	+	MTIF2	chr2	55462710	+
78580	N/A	CA429337	RPTOR	chr17	78929682	+	MTIF2	chr2	55476551	-
78597	N/A	EC455303	RTN4	chr2	55356073	+	MTIF2	chr2	55487369	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
TGCT	MTIF2	0.00017036527450608	0.0048
LUAD	MTIF2	0.00247722624582892	0.067
LUSC	MTIF2	0.00607341125095191	0.16
KIRP	MTIF2	0.0100720184572971	0.25
KIRC	MTIF2	0.0127370370551161	0.31
THCA	MTIF2	0.029773295023983	0.68
HNSC	MTIF2	0.0474137006388139	1

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
STAD	MTIF2	0.0147428245402452	0.46
KIRC	MTIF2	0.0371691661484779	1
LGG	MTIF2	0.000486548146898266	0.016
PAAD	MTIF2	0.00109155054839416	0.035
UCEC	MTIF2	0.0306672437491307	0.92
SARC	MTIF2	0.0411714300188376	1

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source