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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: NCK1 (NCBI Gene ID:4690)

Gene Summary

Gene Summary

Gene Information	Gene Name: NCK1
	Gene ID: 4690
	Gene Symbol	NCK1
	Gene ID	4690
	Gene Name	NCK adaptor protein 1
	Synonyms	NCK\|NCKalpha\|nck-1
	Cytomap	3q22.3
	Type of Gene	protein-coding
	Description	cytoplasmic protein NCK1NCK tyrosine kinaseSH2/SH3 adaptor protein NCK-alphamelanoma NCK proteinnon-catalytic region of tyrosine kinase
	Modification date	20200327
	UniProtAcc	P16333

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0005840	Ribosome
GO:0045727	Positive regulation of translation
GO:0002181	Cytoplasmic translation
GO:0006413	Translational initiation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	NCK1	GO:0033137	negative regulation of peptidyl-serine phosphorylation	14676213\|16835242
Hgene	NCK1	GO:0036493	positive regulation of translation in response to endoplasmic reticulum stress	14676213
Hgene	NCK1	GO:0045944	positive regulation of transcription by RNA polymerase II	10026169
Hgene	NCK1	GO:0060548	negative regulation of cell death	18835251
Hgene	NCK1	GO:0070262	peptidyl-serine dephosphorylation	16835242
Hgene	NCK1	GO:1902237	positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	14676213
Hgene	NCK1	GO:1903676	positive regulation of cap-dependent translational initiation	11959995
Hgene	NCK1	GO:1903679	positive regulation of cap-independent translational initiation	11959995
Hgene	NCK1	GO:1903898	negative regulation of PERK-mediated unfolded protein response	14676213
Hgene	NCK1	GO:1903912	negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation	14676213\|16835242
Hgene	NCK1	GO:1990441	negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	16835242

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
NCK1	(733 - 1119.25]

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Translation Studies in PubMed

We searched PubMed using 'NCK1[title] AND translation [title] AND human.'

Gene	Title	PMID
NCK1	Nck-1 antagonizes the endoplasmic reticulum stress-induced inhibition of translation	14676213

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

ORF

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
BRCA	NCK1	-2.08845188090703	1.93273188036361e-10
LUSC	NCK1	2.01700846379337	2.12944383491207e-05
KIRP	NCK1	-3.37532483072389	6.37955963611603e-08

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
DLBC	NCK1	0.045911169	0.030428538

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with NCK1 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
DLBC	Cell metabolism gene	NCK1	SEC24D	0.802090065	7.26E-12
DLBC	Cell metabolism gene	NCK1	CSGALNACT2	0.839445284	9.07E-14
DLBC	CGC	NCK1	STAG1	0.804344353	5.72E-12
DLBC	CGC	NCK1	NCOA4	0.809054338	3.45E-12
DLBC	CGC	NCK1	ATR	0.811568044	2.62E-12
DLBC	Epifactor	NCK1	EPC1	0.800003491	9.01E-12
DLBC	Epifactor	NCK1	SHPRH	0.807287492	4.18E-12
DLBC	Epifactor	NCK1	ATR	0.811568044	2.62E-12
DLBC	IUPHAR	NCK1	TNKS2	0.800856143	8.25E-12
DLBC	IUPHAR	NCK1	ADAM10	0.807107665	4.26E-12
DLBC	IUPHAR	NCK1	ATR	0.811568044	2.62E-12
DLBC	IUPHAR	NCK1	SLC38A7	0.812289142	2.42E-12
DLBC	IUPHAR	NCK1	ATP2C1	0.812627538	2.33E-12
DLBC	IUPHAR	NCK1	RYK	0.823238091	6.88E-13
DLBC	IUPHAR	NCK1	ATP11B	0.82582763	5.05E-13
DLBC	IUPHAR	NCK1	NR2C2	0.826939403	4.41E-13
DLBC	IUPHAR	NCK1	SLC33A1	0.829821487	3.10E-13
DLBC	IUPHAR	NCK1	ADAM17	0.842624438	5.94E-14
DLBC	Kinase	NCK1	ATR	0.811568044	2.62E-12
DLBC	Kinase	NCK1	RYK	0.823238091	6.88E-13
DLBC	TF	NCK1	ZNF746	0.801196271	7.97E-12
DLBC	TF	NCK1	ZNF699	0.815446912	1.70E-12
DLBC	TF	NCK1	NR2C2	0.826939403	4.41E-13
DLBC	TSG	NCK1	SHPRH	0.807287492	4.18E-12
DLBC	TSG	NCK1	NCOA4	0.809054338	3.45E-12
DLBC	TSG	NCK1	ATR	0.811568044	2.62E-12
DLBC	TSG	NCK1	NR2C2	0.826939403	4.41E-13
PCPG	TF	NCK1	MYNN	0.836221145	3.77E-50
THCA	Epifactor	NCK1	RBBP4	0.800379569	9.06E-129
THCA	IUPHAR	NCK1	SLC25A40	0.809113666	1.03E-133
THYM	Cell metabolism gene	NCK1	NUP153	0.800775409	1.75E-28
THYM	Cell metabolism gene	NCK1	NUP205	0.805846507	4.39E-29
THYM	Cell metabolism gene	NCK1	ACAD8	0.809108164	1.76E-29
THYM	Cell metabolism gene	NCK1	GALK2	0.810121521	1.32E-29
THYM	Cell metabolism gene	NCK1	CDK8	0.810914272	1.06E-29
THYM	Cell metabolism gene	NCK1	TGS1	0.816148372	2.32E-30
THYM	Cell metabolism gene	NCK1	ACADM	0.817373643	1.61E-30
THYM	Cell metabolism gene	NCK1	RQCD1	0.825959893	1.18E-31
THYM	Cell metabolism gene	NCK1	MAT2B	0.830661297	2.64E-32
THYM	Cell metabolism gene	NCK1	POLR2B	0.838887216	1.73E-33
THYM	Cell metabolism gene	NCK1	NUP107	0.840449073	1.01E-33
THYM	Cell metabolism gene	NCK1	MED17	0.869448333	1.48E-38
THYM	CGC	NCK1	FUBP1	0.815320174	2.96E-30
THYM	CGC	NCK1	ABI1	0.819586602	8.33E-31
THYM	CGC	NCK1	BRCA2	0.832627659	1.40E-32
THYM	CGC	NCK1	ATF1	0.848274626	6.32E-35
THYM	CGC	NCK1	RAD21	0.861610717	3.84E-37
THYM	CGC	NCK1	TOP1	0.890224519	8.55E-43
THYM	Epifactor	NCK1	HLTF	0.802545618	1.09E-28
THYM	Epifactor	NCK1	ACTL6A	0.804049469	7.21E-29
THYM	Epifactor	NCK1	SMEK2	0.805474859	4.87E-29
THYM	Epifactor	NCK1	RCOR1	0.808660938	2.00E-29
THYM	Epifactor	NCK1	ACTR6	0.813867496	4.52E-30
THYM	Epifactor	NCK1	PHF20L1	0.815594031	2.73E-30
THYM	Epifactor	NCK1	SMARCAD1	0.819022259	9.87E-31
THYM	Epifactor	NCK1	ING3	0.820427623	6.46E-31
THYM	Epifactor	NCK1	YY1	0.820520189	6.29E-31
THYM	Epifactor	NCK1	DR1	0.825061974	1.56E-31
THYM	Epifactor	NCK1	TAF2	0.829333124	4.05E-32
THYM	Epifactor	NCK1	BRCA2	0.832627659	1.40E-32
THYM	Epifactor	NCK1	UCHL5	0.842239334	5.44E-34
THYM	Epifactor	NCK1	RBBP4	0.858388668	1.38E-36
THYM	IUPHAR	NCK1	CDK8	0.810914272	1.06E-29
THYM	IUPHAR	NCK1	SLC35A3	0.816466991	2.11E-30
THYM	IUPHAR	NCK1	TOP1	0.890224519	8.55E-43
THYM	Kinase	NCK1	CDK8	0.810914272	1.06E-29
THYM	TF	NCK1	ZNF124	0.80004202	2.14E-28
THYM	TF	NCK1	ZNF284	0.800139413	2.08E-28
THYM	TF	NCK1	ZNF776	0.800156731	2.07E-28
THYM	TF	NCK1	ZNF567	0.80473081	5.98E-29
THYM	TF	NCK1	ZNF143	0.80572446	4.54E-29
THYM	TF	NCK1	ZNF430	0.806628921	3.54E-29
THYM	TF	NCK1	ZNF184	0.808652583	2.01E-29
THYM	TF	NCK1	ZBTB1	0.81025436	1.28E-29
THYM	TF	NCK1	ZNF225	0.810258798	1.27E-29
THYM	TF	NCK1	RLF	0.813699403	4.74E-30
THYM	TF	NCK1	SP3	0.814728863	3.51E-30
THYM	TF	NCK1	YY1	0.820520189	6.29E-31
THYM	TF	NCK1	DR1	0.825061974	1.56E-31
THYM	TF	NCK1	ZNF207	0.826219622	1.09E-31
THYM	TF	NCK1	CDC5L	0.834551094	7.41E-33
THYM	TF	NCK1	ZNF227	0.835206109	5.97E-33
THYM	TF	NCK1	ATF1	0.848274626	6.32E-35
THYM	TF	NCK1	ELF1	0.863772062	1.60E-37
THYM	TSG	NCK1	HLTF	0.802545618	1.09E-28
THYM	TSG	NCK1	HACE1	0.810862107	1.07E-29
THYM	TSG	NCK1	ING3	0.820427623	6.46E-31
THYM	TSG	NCK1	CCAR1	0.826735491	9.24E-32
THYM	TSG	NCK1	LIN9	0.830362719	2.91E-32
THYM	TSG	NCK1	BRCA2	0.832627659	1.40E-32
THYM	TSG	NCK1	RANBP9	0.8378959	2.42E-33
THYM	TSG	NCK1	EAF1	0.839292961	1.50E-33
UCEC	Cell metabolism gene	NCK1	PIK3R4	0.802479542	1.66E-46
UCEC	IUPHAR	NCK1	PIK3R4	0.802479542	1.66E-46
UCEC	Kinase	NCK1	PIK3R4	0.802479542	1.66E-46
UCS	Cell metabolism gene	NCK1	NUP153	0.800775409	1.75E-28
UCS	Cell metabolism gene	NCK1	NUP205	0.805846507	4.39E-29
UCS	Cell metabolism gene	NCK1	ACAD8	0.809108164	1.76E-29
UCS	Cell metabolism gene	NCK1	GALK2	0.810121521	1.32E-29
UCS	Cell metabolism gene	NCK1	CDK8	0.810914272	1.06E-29
UCS	Cell metabolism gene	NCK1	TGS1	0.816148372	2.32E-30
UCS	Cell metabolism gene	NCK1	ACADM	0.817373643	1.61E-30
UCS	Cell metabolism gene	NCK1	RQCD1	0.825959893	1.18E-31
UCS	Cell metabolism gene	NCK1	MAT2B	0.830661297	2.64E-32
UCS	Cell metabolism gene	NCK1	POLR2B	0.838887216	1.73E-33
UCS	Cell metabolism gene	NCK1	NUP107	0.840449073	1.01E-33
UCS	Cell metabolism gene	NCK1	MED17	0.869448333	1.48E-38
UCS	CGC	NCK1	FUBP1	0.815320174	2.96E-30
UCS	CGC	NCK1	ABI1	0.819586602	8.33E-31
UCS	CGC	NCK1	BRCA2	0.832627659	1.40E-32
UCS	CGC	NCK1	ATF1	0.848274626	6.32E-35
UCS	CGC	NCK1	RAD21	0.861610717	3.84E-37
UCS	CGC	NCK1	TOP1	0.890224519	8.55E-43
UCS	Epifactor	NCK1	HLTF	0.802545618	1.09E-28
UCS	Epifactor	NCK1	ACTL6A	0.804049469	7.21E-29
UCS	Epifactor	NCK1	SMEK2	0.805474859	4.87E-29
UCS	Epifactor	NCK1	RCOR1	0.808660938	2.00E-29
UCS	Epifactor	NCK1	ACTR6	0.813867496	4.52E-30
UCS	Epifactor	NCK1	PHF20L1	0.815594031	2.73E-30
UCS	Epifactor	NCK1	SMARCAD1	0.819022259	9.87E-31
UCS	Epifactor	NCK1	ING3	0.820427623	6.46E-31
UCS	Epifactor	NCK1	YY1	0.820520189	6.29E-31
UCS	Epifactor	NCK1	DR1	0.825061974	1.56E-31
UCS	Epifactor	NCK1	TAF2	0.829333124	4.05E-32
UCS	Epifactor	NCK1	BRCA2	0.832627659	1.40E-32
UCS	Epifactor	NCK1	UCHL5	0.842239334	5.44E-34
UCS	Epifactor	NCK1	RBBP4	0.858388668	1.38E-36
UCS	IUPHAR	NCK1	CDK8	0.810914272	1.06E-29
UCS	IUPHAR	NCK1	SLC35A3	0.816466991	2.11E-30
UCS	IUPHAR	NCK1	TOP1	0.890224519	8.55E-43
UCS	Kinase	NCK1	CDK8	0.810914272	1.06E-29
UCS	TF	NCK1	ZNF124	0.80004202	2.14E-28
UCS	TF	NCK1	ZNF284	0.800139413	2.08E-28
UCS	TF	NCK1	ZNF776	0.800156731	2.07E-28
UCS	TF	NCK1	ZNF567	0.80473081	5.98E-29
UCS	TF	NCK1	ZNF143	0.80572446	4.54E-29
UCS	TF	NCK1	ZNF430	0.806628921	3.54E-29
UCS	TF	NCK1	ZNF184	0.808652583	2.01E-29
UCS	TF	NCK1	ZBTB1	0.81025436	1.28E-29
UCS	TF	NCK1	ZNF225	0.810258798	1.27E-29
UCS	TF	NCK1	RLF	0.813699403	4.74E-30
UCS	TF	NCK1	SP3	0.814728863	3.51E-30
UCS	TF	NCK1	YY1	0.820520189	6.29E-31
UCS	TF	NCK1	DR1	0.825061974	1.56E-31
UCS	TF	NCK1	ZNF207	0.826219622	1.09E-31
UCS	TF	NCK1	CDC5L	0.834551094	7.41E-33
UCS	TF	NCK1	ZNF227	0.835206109	5.97E-33
UCS	TF	NCK1	ATF1	0.848274626	6.32E-35
UCS	TF	NCK1	ELF1	0.863772062	1.60E-37
UCS	TSG	NCK1	HLTF	0.802545618	1.09E-28
UCS	TSG	NCK1	HACE1	0.810862107	1.07E-29
UCS	TSG	NCK1	ING3	0.820427623	6.46E-31
UCS	TSG	NCK1	CCAR1	0.826735491	9.24E-32
UCS	TSG	NCK1	LIN9	0.830362719	2.91E-32
UCS	TSG	NCK1	BRCA2	0.832627659	1.40E-32
UCS	TSG	NCK1	RANBP9	0.8378959	2.42E-33
UCS	TSG	NCK1	EAF1	0.839292961	1.50E-33
UVM	Cell metabolism gene	NCK1	XPO1	0.800925399	4.72E-19
UVM	Cell metabolism gene	NCK1	POLR2B	0.803172703	3.17E-19
UVM	Cell metabolism gene	NCK1	PIKFYVE	0.80335107	3.07E-19
UVM	Cell metabolism gene	NCK1	GPAM	0.806252072	1.83E-19
UVM	Cell metabolism gene	NCK1	MED17	0.807319545	1.51E-19
UVM	Cell metabolism gene	NCK1	PRKAA1	0.810668599	8.13E-20
UVM	Cell metabolism gene	NCK1	GNPDA2	0.812315546	5.98E-20
UVM	Cell metabolism gene	NCK1	PHAX	0.812501478	5.78E-20
UVM	Cell metabolism gene	NCK1	DPM1	0.813207629	5.06E-20
UVM	Cell metabolism gene	NCK1	NUDT12	0.815759169	3.12E-20
UVM	Cell metabolism gene	NCK1	CSGALNACT2	0.816242821	2.84E-20
UVM	Cell metabolism gene	NCK1	EDEM3	0.817224745	2.35E-20
UVM	Cell metabolism gene	NCK1	NAMPT	0.817611341	2.18E-20
UVM	Cell metabolism gene	NCK1	L2HGDH	0.818018558	2.02E-20
UVM	Cell metabolism gene	NCK1	TNPO1	0.821655578	9.88E-21
UVM	Cell metabolism gene	NCK1	GCLC	0.822679303	8.05E-21
UVM	Cell metabolism gene	NCK1	MTMR6	0.823657804	6.62E-21
UVM	Cell metabolism gene	NCK1	PIP5K1A	0.824323375	5.79E-21
UVM	Cell metabolism gene	NCK1	SLC25A16	0.824733276	5.33E-21
UVM	Cell metabolism gene	NCK1	C1GALT1	0.825262918	4.79E-21
UVM	Cell metabolism gene	NCK1	PSMC6	0.827097707	3.29E-21
UVM	Cell metabolism gene	NCK1	BPNT1	0.827135905	3.27E-21
UVM	Cell metabolism gene	NCK1	ACSL4	0.827925359	2.78E-21
UVM	Cell metabolism gene	NCK1	TBL1XR1	0.830638905	1.58E-21
UVM	Cell metabolism gene	NCK1	PPAT	0.833704636	8.23E-22
UVM	Cell metabolism gene	NCK1	FBXL3	0.840604076	1.81E-22
UVM	Cell metabolism gene	NCK1	CNOT8	0.842260189	1.25E-22
UVM	Cell metabolism gene	NCK1	AGPS	0.843474519	9.44E-23
UVM	Cell metabolism gene	NCK1	PNPLA8	0.858236088	2.66E-24
UVM	Cell metabolism gene	NCK1	IDI1	0.859101342	2.13E-24
UVM	Cell metabolism gene	NCK1	PIK3CA	0.879656518	6.83E-27
UVM	Cell metabolism gene	NCK1	AASDHPPT	0.883418235	2.13E-27
UVM	Cell metabolism gene	NCK1	SACM1L	0.888194882	4.57E-28
UVM	Cell metabolism gene	NCK1	CPOX	0.904341017	1.43E-30
UVM	CGC	NCK1	XPO1	0.800925399	4.72E-19
UVM	CGC	NCK1	ABI1	0.805727432	2.01E-19
UVM	CGC	NCK1	CREB1	0.808059934	1.32E-19
UVM	CGC	NCK1	PHF6	0.808687199	1.17E-19
UVM	CGC	NCK1	SF3B1	0.812574147	5.70E-20
UVM	CGC	NCK1	RAD17	0.813349576	4.92E-20
UVM	CGC	NCK1	DEK	0.815945907	3.01E-20
UVM	CGC	NCK1	STAG1	0.823233207	7.21E-21
UVM	CGC	NCK1	ATF1	0.82403582	6.14E-21
UVM	CGC	NCK1	ERCC4	0.828345483	2.54E-21
UVM	CGC	NCK1	CDC73	0.829808601	1.88E-21
UVM	CGC	NCK1	TBL1XR1	0.830638905	1.58E-21
UVM	CGC	NCK1	MSH2	0.83069409	1.56E-21
UVM	CGC	NCK1	ATR	0.835381915	5.73E-22
UVM	CGC	NCK1	SUZ12	0.841691226	1.42E-22
UVM	CGC	NCK1	PALB2	0.860670013	1.42E-24
UVM	CGC	NCK1	PIK3CA	0.879656518	6.83E-27
UVM	Epifactor	NCK1	TAF7	0.800430823	5.15E-19
UVM	Epifactor	NCK1	CHD1	0.804637855	2.44E-19
UVM	Epifactor	NCK1	UCHL5	0.804906029	2.33E-19
UVM	Epifactor	NCK1	NSL1	0.808272653	1.26E-19
UVM	Epifactor	NCK1	EPC2	0.808865889	1.13E-19
UVM	Epifactor	NCK1	PRKAA1	0.810668599	8.13E-20
UVM	Epifactor	NCK1	SF3B1	0.812574147	5.70E-20
UVM	Epifactor	NCK1	TADA1	0.813190748	5.07E-20
UVM	Epifactor	NCK1	RMI1	0.813256028	5.01E-20
UVM	Epifactor	NCK1	DEK	0.815945907	3.01E-20
UVM	Epifactor	NCK1	CUL5	0.816018246	2.96E-20
UVM	Epifactor	NCK1	HAT1	0.819163633	1.61E-20
UVM	Epifactor	NCK1	PHC3	0.821525718	1.01E-20
UVM	Epifactor	NCK1	SIRT1	0.825527329	4.54E-21
UVM	Epifactor	NCK1	SMEK2	0.825715684	4.37E-21
UVM	Epifactor	NCK1	CUL2	0.828064354	2.70E-21
UVM	Epifactor	NCK1	CDC73	0.829808601	1.88E-21
UVM	Epifactor	NCK1	FAM175B	0.830402488	1.66E-21
UVM	Epifactor	NCK1	TBL1XR1	0.830638905	1.58E-21
UVM	Epifactor	NCK1	UBR2	0.831977243	1.19E-21
UVM	Epifactor	NCK1	ATR	0.835381915	5.73E-22
UVM	Epifactor	NCK1	RLIM	0.836087075	4.92E-22
UVM	Epifactor	NCK1	YEATS4	0.837090904	3.95E-22
UVM	Epifactor	NCK1	SUZ12	0.841691226	1.42E-22
UVM	Epifactor	NCK1	CHUK	0.842742697	1.12E-22
UVM	Epifactor	NCK1	ATF2	0.843385836	9.63E-23
UVM	Epifactor	NCK1	HLTF	0.85255114	1.10E-23
UVM	Epifactor	NCK1	PPP4R2	0.860577221	1.46E-24
UVM	Epifactor	NCK1	YY1	0.897016202	2.20E-29
UVM	IUPHAR	NCK1	XPO1	0.800925399	4.72E-19
UVM	IUPHAR	NCK1	PIKFYVE	0.80335107	3.07E-19
UVM	IUPHAR	NCK1	STK38L	0.805532848	2.08E-19
UVM	IUPHAR	NCK1	PRKAA1	0.810668599	8.13E-20
UVM	IUPHAR	NCK1	SLC33A1	0.814830824	3.72E-20
UVM	IUPHAR	NCK1	RYK	0.817292086	2.32E-20
UVM	IUPHAR	NCK1	HAT1	0.819163633	1.61E-20
UVM	IUPHAR	NCK1	ATP11B	0.821469805	1.02E-20
UVM	IUPHAR	NCK1	PRPF4B	0.821490212	1.02E-20
UVM	IUPHAR	NCK1	PIP5K1A	0.824323375	5.79E-21
UVM	IUPHAR	NCK1	SLC25A16	0.824733276	5.33E-21
UVM	IUPHAR	NCK1	SIRT1	0.825527329	4.54E-21
UVM	IUPHAR	NCK1	SCYL2	0.829752265	1.90E-21
UVM	IUPHAR	NCK1	SLC25A24	0.832415017	1.08E-21
UVM	IUPHAR	NCK1	OXSR1	0.833436136	8.72E-22
UVM	IUPHAR	NCK1	PPAT	0.833704636	8.23E-22
UVM	IUPHAR	NCK1	ATR	0.835381915	5.73E-22
UVM	IUPHAR	NCK1	USP14	0.836327492	4.67E-22
UVM	IUPHAR	NCK1	BIRC2	0.839098564	2.53E-22
UVM	IUPHAR	NCK1	CHUK	0.842742697	1.12E-22
UVM	IUPHAR	NCK1	RIOK3	0.845996628	5.27E-23
UVM	IUPHAR	NCK1	SLC30A5	0.84724096	3.94E-23
UVM	IUPHAR	NCK1	CSNK1G3	0.857448538	3.25E-24
UVM	IUPHAR	NCK1	IDI1	0.859101342	2.13E-24
UVM	IUPHAR	NCK1	PIK3CA	0.879656518	6.83E-27
UVM	IUPHAR	NCK1	SLC25A46	0.881167798	4.30E-27
UVM	IUPHAR	NCK1	MFN1	0.884835468	1.36E-27
UVM	Kinase	NCK1	STK38L	0.805532848	2.08E-19
UVM	Kinase	NCK1	PRKAA1	0.810668599	8.13E-20
UVM	Kinase	NCK1	RYK	0.817292086	2.32E-20
UVM	Kinase	NCK1	PRPF4B	0.821490212	1.02E-20
UVM	Kinase	NCK1	SCYL2	0.829752265	1.90E-21
UVM	Kinase	NCK1	OXSR1	0.833436136	8.72E-22
UVM	Kinase	NCK1	ATR	0.835381915	5.73E-22
UVM	Kinase	NCK1	CHUK	0.842742697	1.12E-22
UVM	Kinase	NCK1	RIOK3	0.845996628	5.27E-23
UVM	Kinase	NCK1	CSNK1G3	0.857448538	3.25E-24
UVM	TF	NCK1	ZNF281	0.80064801	4.95E-19
UVM	TF	NCK1	ZNF461	0.800838311	4.79E-19
UVM	TF	NCK1	CGGBP1	0.801045556	4.62E-19
UVM	TF	NCK1	ZNF611	0.80193047	3.95E-19
UVM	TF	NCK1	BACH1	0.8033993	3.05E-19
UVM	TF	NCK1	THAP1	0.804134754	2.67E-19
UVM	TF	NCK1	THAP5	0.804388239	2.56E-19
UVM	TF	NCK1	ZNF136	0.804824437	2.36E-19
UVM	TF	NCK1	ZNF654	0.804967524	2.30E-19
UVM	TF	NCK1	ZNF254	0.80506485	2.26E-19
UVM	TF	NCK1	ZBTB1	0.806463405	1.76E-19
UVM	TF	NCK1	ZBTB41	0.806620965	1.71E-19
UVM	TF	NCK1	ZNF45	0.807028961	1.59E-19
UVM	TF	NCK1	CREB1	0.808059934	1.32E-19
UVM	TF	NCK1	ELF1	0.808145273	1.29E-19
UVM	TF	NCK1	GPBP1	0.808980353	1.11E-19
UVM	TF	NCK1	ZKSCAN5	0.809830545	9.50E-20
UVM	TF	NCK1	ZBTB6	0.809848806	9.47E-20
UVM	TF	NCK1	ZNF813	0.810236722	8.81E-20
UVM	TF	NCK1	ZNF267	0.810595706	8.24E-20
UVM	TF	NCK1	ZNF283	0.811095436	7.51E-20
UVM	TF	NCK1	ZNF420	0.812195897	6.12E-20
UVM	TF	NCK1	ZNF41	0.812324935	5.97E-20
UVM	TF	NCK1	FOXN2	0.812961362	5.30E-20
UVM	TF	NCK1	ZNF614	0.817707018	2.14E-20
UVM	TF	NCK1	ZNF627	0.81802896	2.01E-20
UVM	TF	NCK1	LIN54	0.818392718	1.87E-20
UVM	TF	NCK1	ZNF440	0.822097937	9.04E-21
UVM	TF	NCK1	CEBPZ	0.822358475	8.59E-21
UVM	TF	NCK1	NFXL1	0.823786101	6.45E-21
UVM	TF	NCK1	ATF1	0.82403582	6.14E-21
UVM	TF	NCK1	ZNF791	0.82502173	5.03E-21
UVM	TF	NCK1	ZNF432	0.826760724	3.53E-21
UVM	TF	NCK1	TMF1	0.82806726	2.70E-21
UVM	TF	NCK1	SMAD5	0.83038664	1.66E-21
UVM	TF	NCK1	ZNF320	0.831662366	1.27E-21
UVM	TF	NCK1	ZNF845	0.834727084	6.60E-22
UVM	TF	NCK1	ZNF639	0.835418842	5.69E-22
UVM	TF	NCK1	ZNF24	0.83543214	5.67E-22
UVM	TF	NCK1	ZNF701	0.839640201	2.25E-22
UVM	TF	NCK1	ZNF468	0.840652985	1.79E-22
UVM	TF	NCK1	ATF2	0.843385836	9.63E-23
UVM	TF	NCK1	ZNF28	0.847529158	3.68E-23
UVM	TF	NCK1	ZBTB11	0.849808387	2.14E-23
UVM	TF	NCK1	SP3	0.85982888	1.77E-24
UVM	TF	NCK1	GABPA	0.866863434	2.73E-25
UVM	TF	NCK1	ZNF184	0.867186811	2.50E-25
UVM	TF	NCK1	ZNF131	0.874588439	3.09E-26
UVM	TF	NCK1	ZNF148	0.877214101	1.42E-26
UVM	TF	NCK1	MYNN	0.878400455	9.98E-27
UVM	TF	NCK1	YY1	0.897016202	2.20E-29
UVM	TSG	NCK1	LIN9	0.801197773	4.50E-19
UVM	TSG	NCK1	CHD1	0.804637855	2.44E-19
UVM	TSG	NCK1	PHF6	0.808687199	1.17E-19
UVM	TSG	NCK1	TANK	0.809544684	1.00E-19
UVM	TSG	NCK1	PRKAA1	0.810668599	8.13E-20
UVM	TSG	NCK1	PPM1A	0.812853525	5.41E-20
UVM	TSG	NCK1	CUL5	0.816018246	2.96E-20
UVM	TSG	NCK1	RANBP9	0.816508918	2.70E-20
UVM	TSG	NCK1	PHC3	0.821525718	1.01E-20
UVM	TSG	NCK1	SIRT1	0.825527329	4.54E-21
UVM	TSG	NCK1	CUL2	0.828064354	2.70E-21
UVM	TSG	NCK1	CDC73	0.829808601	1.88E-21
UVM	TSG	NCK1	MSH2	0.83069409	1.56E-21
UVM	TSG	NCK1	ATR	0.835381915	5.73E-22
UVM	TSG	NCK1	SUZ12	0.841691226	1.42E-22
UVM	TSG	NCK1	CHUK	0.842742697	1.12E-22
UVM	TSG	NCK1	HLTF	0.85255114	1.10E-23
UVM	TSG	NCK1	PALB2	0.860670013	1.42E-24
UVM	TSG	NCK1	ECT2	0.866119223	3.34E-25

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
COAD	NCK1	CDC42	-2.2640573059658	0.000125885009765625
LUSC	NCK1	CDC42	-1.32952300607616	0.000431975220131112
LIHC	NCK1	NPHS1	-1.04631683480058	0.00070993257333961
KIRP	NCK1	LCP2	-2.27744552983154	0.000980085227638483
STAD	NCK1	WASL	-1.81042588602242	0.00143672106787562
KIRC	NCK1	CDC42	-1.22188486751084	0.00220467399393826
HNSC	NCK1	WIPF1	-1.1317074528203	0.00498432417884942
CHOL	NCK1	NPHS1	-4.25064888606967	0.0142661867014469
UCEC	NCK1	WIPF1	3.6198602256345	0.015625
PRAD	NCK1	KDR	-1.58796255343738	0.0194951957597077
KICH	NCK1	WIPF1	-2.67180509261946	0.0219083428382874
ESCA	NCK1	WASL	-1.76047279146432	0.0244140625
READ	NCK1	CDC42	-2.89472372432256	0.03125
READ	NCK1	WASL	-8.07531071992977	0.03125
THCA	NCK1	LCP2	-1.19335805929689	0.0484049760061147
LUAD	NCK1	WAS	-1.24368890484542	1.03207777888518e-06
PRAD	NCK1	WIPF1	1.64414344697711	1.15996224044503e-05
BRCA	NCK1	NPHS1	-1.92014454328342	1.17868654242659e-09
BRCA	NCK1	CDC42	1.53775410810954	1.344517500009e-07
BRCA	NCK1	KDR	-1.01112009429379	1.35259778392042e-14
PRAD	NCK1	PAK1	1.99443643932778	2.04165287904647e-06
LUSC	NCK1	LCP2	-2.57125249415915	3.05309271735189e-09
COAD	NCK1	WASL	-2.04452450106745	4.17232513427735e-07
KIRC	NCK1	NPHS1	-2.67100943365389	5.95530520218696e-10
LUAD	NCK1	KDR	-1.05756116228192	8.0748918934853e-08
KICH	NCK1	NPHS1	-3.91534965627019	8.34465026855468e-07
KIRP	NCK1	NPHS1	-3.15978603773708	8.84756445884705e-09

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with NCK1

EPHB1, MINK1, ERBB4, LCP2, ARHGAP32, Mta1, Mta3, BLNK, SOS1, DNM1, SOCS1, RASA1, PKN2, WASL, RRAS, EGFR, KHDRBS1, MAP4K4, DAG1, PXN, MAP4K1, NEDD9, PTK2, DCC, WAS, PDGFRB, TBK1, PAK1, CBL, RALGPS1, SOCS7, FASLG, DRD4, CD3E, ABL1, GAB2, BCAR1, ABI1, WIPF1, PFN1, DOK2, CAV2, NCKIPSD, UBA52, PIK3R1, SYK, INPP5D, UBASH3B, GRB2, TNK2, ADAM15, nef, DOK1, FGFR1, TUBA1A, Caskin1, ERBB3, Mbp, HSPA5, Dok1, PHC2, LPHN2, KIAA1522, SHANK3, SYNPO, ADIPOR2, NCK2, FAM217B, FMR1, OLIG1, PIK3R3, SH2D1A, EIF2S2, CEP170, APBB2, TRRAP, UXT, RAD54L, PAPSS1, CLINT1, TRIM14, UBR4, DROSHA, RTEL1, HEATR3, WIPF2, GHR, ABL2, KDR, CDH1, DUSP12, CPNE5, LRFN4, ABI2, SORBS3, EFS, GMPPA, NUTM2F, HOMEZ, FCHO1, ARHGEF2, RAPGEF5, CANX, DCAF15, PTPN12, DLGAP4, CHN2, PIK3AP1, PAK2, NHSL2, DAB1, ABCF1, RPL30, IVNS1ABP, PRPSAP1, PRPS1, PRPSAP2, DSG1, DSP, JUP, P4HB, RPL6, RPL12, RPLP0P6, RPLP0, GIT1, RPL10A, RPL35A, GIT2, ARHGEF7, MBP, STK38, NCK1, PRPS2, GAB1, KIT, MET, CHN1, ERBB2, HNRNPH1, DDX39A, TNIK, TTC28, ASAP2, SEMA6A, SH3PXD2B, NHSL1, CYFIP2, LAD1, BRK1, SOS2, WASF2, NCKAP1, CASKIN2, DLL1, NCKAP5, BAIAP2, FAM83H, WASF1, ARAP1, DLG5, WIPF3, ARHGEF6, CYFIP1, N, nsp11, nsp13, nsp14,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
NCK1	chr3	136664970	G	C	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
NCK1	STAD	chr3	136646968	136646968	G	A	Missense_Mutation	p.R42Q	3
NCK1	LIHC	chr3	136647018	136647018	A	-	Frame_Shift_Del	p.K59fs	3
NCK1	PAAD	chr3	136667191	136667191	C	T	Missense_Mutation		3
NCK1	UCEC	chr3	136664466	136664466	G	A	Missense_Mutation	p.A90T	3
NCK1	PAAD	chr3	136667191	136667191	C	T	Missense_Mutation	p.R344C	3
NCK1	BRCA	chr3	136667105	136667105	A	G	Missense_Mutation	p.N315S	3
NCK1	LGG	chr3	136646967	136646967	C	T	Nonsense_Mutation		3
NCK1	PAAD	chr3	136667191	136667191	C	T	Missense_Mutation	p.R280C	3
NCK1	STAD	chr3	136646885	136646885	G	T	Silent		2
NCK1	CESC	chr3	136664512	136664512	A	G	Missense_Mutation		2
NCK1	PAAD	chr3	136664506	136664506	G	A	Missense_Mutation		2
NCK1	STAD	chr3	136646885	136646885	G	T	Silent	p.V14V	2
NCK1	PAAD	chr3	136664529	136664529	G	A	Missense_Mutation		2
NCK1	THCA	chr3	136646925	136646925	A	G	Missense_Mutation	p.R28G	2
NCK1	BLCA	chr3	136667120	136667120	C	T	Missense_Mutation	p.S256L	2
NCK1	STAD	chr3	136665004	136665004	T	C	Missense_Mutation	p.I269T	2
NCK1	CESC	chr3	136664512	136664512	A	G	Missense_Mutation	p.Y105C	2
NCK1	LGG	chr3	136646967	136646967	C	T	Nonsense_Mutation	p.R42X	2
NCK1	STAD	chr3	136665098	136665098	A	G	Silent	p.G300G	2
NCK1	PAAD	chr3	136664506	136664506	G	A	Missense_Mutation	p.R103H	2
NCK1	LGG	chr3	136646967	136646967	C	T	Nonsense_Mutation	p.R42*	2
NCK1	STAD	chr3	136664754	136664754	C	T	Silent	p.L186L	2
NCK1	ESCA	chr3	136664643	136664643	A	C	Missense_Mutation	p.N149H	2
NCK1	UCEC	chr3	136664729	136664729	G	T	Missense_Mutation	p.E177D	2
NCK1	ESCA	chr3	136664643	136664643	A	C	Missense_Mutation		2
NCK1	STAD	chr3	136664893	136664893	G	A	Missense_Mutation	p.C232Y	2
NCK1	PAAD	chr3	136664529	136664529	G	A	Missense_Mutation	p.A111T	2
NCK1	UCEC	chr3	136665108	136665108	G	T	Missense_Mutation	p.D304Y	2
NCK1	ESCA	chr3	136664528	136664528	C	T	Silent		2
NCK1	STAD	chr3	136664679	136664679	A	G	Missense_Mutation	p.T161A	2
NCK1	LUAD	chr3	136664548	136664548	A	G	Missense_Mutation	p.Y53C	2
NCK1	UCS	chr3	136664877	136664877	C	T	Missense_Mutation	p.P163S	2
NCK1	STAD	chr3	136664515	136664515	A	C	Missense_Mutation		2
NCK1	ESCA	chr3	136664528	136664528	C	T	Silent	p.P46P	1
NCK1	LUAD	chr3	136664879	136664879	A	T	Silent	p.P163P	1
NCK1	READ	chr3	136664729	136664729	G	T	Missense_Mutation	p.E113D	1
NCK1	BLCA	chr3	136664965	136664965	C	A	Missense_Mutation		1
NCK1	HNSC	chr3	136664663	136664663	C	A	Missense_Mutation	p.F155L	1
NCK1	LIHC	chr3	136646918	136646918	G	A	Silent		1
NCK1	HNSC	chr3	136664663	136664663	C	A	Missense_Mutation		1
NCK1	LUAD	chr3	136646998	136646998	C	T	Missense_Mutation	p.P52L	1
NCK1	STAD	chr3	136664467	136664467	C	T	Missense_Mutation	p.A90V	1
NCK1	SKCM	chr3	136664568	136664568	G	T	Nonsense_Mutation	p.E60X	1
NCK1	BLCA	chr3	136646888	136646888	C	G	Silent		1
NCK1	HNSC	chr3	136665013	136665013	C	T	Missense_Mutation	p.S272L	1
NCK1	STAD	chr3	136664515	136664515	A	C	Missense_Mutation	p.D106A	1
NCK1	CESC	chr3	136664454	136664454	G	A	Missense_Mutation	p.V22M	1
NCK1	LIHC	chr3	136664942	136664942	C	A	Silent		1
NCK1	HNSC	chr3	136665013	136665013	C	T	Missense_Mutation		1
NCK1	LUAD	chr3	136664575	136664575	C	T	Missense_Mutation	p.S62L	1
NCK1	THCA	chr3	136646925	136646925	A	G	Missense_Mutation		1
NCK1	SKCM	chr3	136664698	136664698	C	T	Missense_Mutation	p.P103L	1
NCK1	BLCA	chr3	136664519	136664519	C	G	Silent	p.L43L	1
NCK1	HNSC	chr3	136664745	136664745	G	A	Missense_Mutation	p.V183I	1
NCK1	CESC	chr3	136664454	136664454	G	A	Missense_Mutation	p.V86M	1
NCK1	HNSC	chr3	136646889	136646889	C	A	Missense_Mutation		1
NCK1	LUSC	chr3	136664723	136664723	G	T	Silent	p.L175L	1
NCK1	SKCM	chr3	136667285	136667285	A	T	Missense_Mutation	p.H311L	1
NCK1	HNSC	chr3	136667114	136667114	C	G	Nonsense_Mutation	p.S318*	1
NCK1	LIHC	chr3	136647048	136647048	A	-	Frame_Shift_Del	p.K69fs	1
NCK1	HNSC	chr3	136664745	136664745	G	A	Missense_Mutation		1
NCK1	LUSC	chr3	136665037	136665037	A	G	Missense_Mutation	p.N280S	1
NCK1	THCA	chr3	136647064	136647064	C	T	Missense_Mutation	p.T74I	1
NCK1	SKCM	chr3	136665000	136665000	T	G	Missense_Mutation	p.Y204D	1
NCK1	BLCA	chr3	136664750	136664750	T	C	Silent	p.N120N	1
NCK1	COAD	chr3	136664708	136664708	C	T	Silent	p.D106D	1
NCK1	LIHC	chr3	136664869	136664869	A	-	Frame_Shift_Del	p.E160fs	1
NCK1	HNSC	chr3	136646895	136646895	G	A	Missense_Mutation		1
NCK1	LUSC	chr3	136646961	136646961	C	T	Nonsense_Mutation	p.R40*	1
NCK1	SKCM	chr3	136665116	136665116	C	T	Silent	p.L242L	1
NCK1	BLCA	chr3	136664965	136664965	C	A	Missense_Mutation	p.T192N	1
NCK1	LIHC	chr3	136664927	136664927	A	-	Frame_Shift_Del	p.P179fs	1
NCK1	HNSC	chr3	136664663	136664663	C	A	Missense_Mutation	p.F91L	1
NCK1	SKCM	chr3	136664568	136664568	G	T	Nonsense_Mutation	p.E60*	1
NCK1	BLCA	chr3	136646888	136646888	C	G	Silent	p.A15A	1
NCK1	LGG	chr3	136664742	136664742	G	A	Missense_Mutation	p.V118I	1
NCK1	LIHC	chr3	136667137	136667137	A	-	Frame_Shift_Del	p.K262fs	1
NCK1	HNSC	chr3	136664745	136664745	G	A	Missense_Mutation	p.V119I	1
NCK1	SKCM	chr3	136664464	136664464	C	T	Missense_Mutation	p.S25F	1
NCK1	BLCA	chr3	136667120	136667120	C	T	Missense_Mutation	p.S320L	1
NCK1	LGG	chr3	136665137	136665137	G	A	Splice_Site	p.S249_splice	1
NCK1	LIHC	chr3	136667264	136667264	A	-	Frame_Shift_Del	p.E304fs	1
NCK1	BLCA	chr3	136664519	136664519	C	G	Silent		1
NCK1	HNSC	chr3	136667114	136667114	C	G	Nonsense_Mutation	p.S254*	1
NCK1	PAAD	chr3	136664529	136664529	G	A	Missense_Mutation	p.A47T	1
NCK1	UCS	chr3	136664877	136664877	C	T	Missense_Mutation		1
NCK1	SKCM	chr3	136664754	136664754	C	T	Silent	p.L122L	1
NCK1	ESCA	chr3	136664528	136664528	C	T	Silent	p.P110P	1
NCK1	STAD	chr3	136664515	136664515	A	C	Missense_Mutation	p.D42A	1
NCK1	UCS	chr3	136664877	136664877	C	T	Missense_Mutation	p.P227S	1
NCK1	BLCA	chr3	136667120	136667120	C	T	Missense_Mutation		1
NCK1	HNSC	chr3	136665013	136665013	C	T	Missense_Mutation	p.S208L	1
NCK1	SKCM	chr3	136664664	136664664	C	T	Missense_Mutation	p.P92S	1
NCK1	CESC	chr3	136664971	136664971	G	T	Missense_Mutation		1
NCK1	LIHC	chr3	136646897	136646897	A	G	Silent		1
NCK1	ESCA	chr3	136664643	136664643	A	C	Missense_Mutation	p.N85H	1
NCK1	LUAD	chr3	136665091	136665091	A	G	Missense_Mutation	p.E234G	1
NCK1	STAD	chr3	136664858	136664858	T	G	Missense_Mutation	p.I220M	1
NCK1	PAAD	chr3	136664506	136664506	G	A	Missense_Mutation	p.R39H	1
NCK1	BLCA	chr3	136664750	136664750	T	C	Silent		1
NCK1	HNSC	chr3	136646895	136646895	G	A	Missense_Mutation	p.E18K	1
NCK1	CESC	chr3	136664454	136664454	G	A	Missense_Mutation		1
NCK1	LIHC	chr3	136664950	136664950	A	G	Missense_Mutation		1

Copy number variation (CNV) of NCK1
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across NCK1
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
103338	COAD	TCGA-AA-3819	GSK3B	chr3	119812193	-	NCK1	chr3	136646825	+
103338	HNSC	TCGA-QK-A8ZB	HEBP1	chr12	13140085	-	NCK1	chr3	136667100	+
103338	HNSC	TCGA-QK-A8ZB-01A	HEBP1	chr12	13140086	-	NCK1	chr3	136667101	+
103338	HNSC	TCGA-CX-7086	IL20RB	chr3	136714398	+	NCK1	chr3	136646826	+
103338	MESO	TCGA-XT-AASU	KPNA1	chr3	122215283	-	NCK1	chr3	136646825	+
103338	MESO	TCGA-XT-AASU-01A	KPNA1	chr3	122215284	-	NCK1	chr3	136646826	+
103244	PRAD	TCGA-HC-8213	NCK1	chr3	136581161	+	AMACR	chr5	34006004	-
100021	STAD	TCGA-BR-8364-01A	NCK1	chr3	136581161	+	BIRC6	chr2	32768308	+
93401	N/A	BG230993	NCK1	chr3	136652564	+	GABARAP	chr17	7143738	+
57600	HNSC	TCGA-QK-A8ZB-01A	NCK1	chr3	136665137	+	HEBP1	chr12	13128413	-
87077	BRCA	TCGA-AN-A03Y	NCK1	chr3	136647069	+	IL20RB	chr3	136708282	+
87077	CHOL	TCGA-ZH-A8Y4-01A	NCK1	chr3	136581161	+	IL20RB	chr3	136699308	+
87077	ESCA	TCGA-IG-A51D	NCK1	chr3	136647069	+	IL20RB	chr3	136699307	+
87077	ESCA	TCGA-L5-A4OS	NCK1	chr3	136665137	+	IL20RB	chr3	136728954	+
87077	LUSC	TCGA-37-4135	NCK1	chr3	136581161	+	IL20RB	chr3	136714256	+
87077	LUSC	TCGA-63-A5MH	NCK1	chr3	136647069	+	IL20RB	chr3	136728954	+
101068	BLCA	TCGA-4Z-AA7Q	NCK1	chr3	136581161	+	PCCB	chr3	136002678	+
101068	BLCA	TCGA-4Z-AA7Q	NCK1	chr3	136581161	+	PCCB	chr3	136002679	+
101068	BLCA	TCGA-4Z-AA7Q	NCK1	chr3	136581195	+	PCCB	chr3	136002679	+
71467	BRCA	TCGA-AO-A0J4-01A	NCK1	chr3	136581161	+	RAB6B	chr3	133560507	-
71467	BRCA	TCGA-AO-A0J4-01A	NCK1	chr3	136581195	+	RAB6B	chr3	133560507	-
92891	COAD	TCGA-A6-6650	NCK1	chr3	136647069	+	STAG1	chr3	136096594	-
92891	HNSC	TCGA-UF-A7JA	NCK1	chr3	136647069	+	STAG1	chr3	136240259	-
92891	HNSC	TCGA-UF-A7JA	NCK1	chr3	136664594	+	STAG1	chr3	136240259	-
92891	N/A	EC439805	NCK1	chr3	136622748	-	STAG1	chr3	136430946	-
103338	N/A	BG998714	RAB11FIP3	chr16	546434	+	NCK1	chr3	136665066	+
103338	SKCM	TCGA-D3-A3BZ-06A	SGK3	chr8	67755782	+	NCK1	chr3	136667101	+
103338	Non-Cancer	ERR315428	SLC35G2	chr3	136538056	+	NCK1	chr3	136646826	+
103338	ESCA	TCGA-LN-A5U7	STAG1	chr3	136471036	-	NCK1	chr3	136646825	+
103338	LUSC	TCGA-94-8035	STAG1	chr3	136221470	-	NCK1	chr3	136646826	+
103344	BRCA	TCGA-AC-A6IW-01A	ZZZ3	chr1	78148270	-	NCK1	chr3	136646826	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
HNSC	NCK1	0.00114437269860723	0.032
BRCA	NCK1	0.00447305274977545	0.12
BLCA	NCK1	0.0420930754943898	1

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
THCA	NCK1	0.00544768031494965	0.17
BRCA	NCK1	0.0256107027857018	0.79
SKCM	NCK1	0.0460171610766313	1
ESCA	NCK1	2.81307260347919e-06	9.3e-05
MESO	NCK1	0.0378180123493666	1

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source