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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: NDUFA7 (NCBI Gene ID:4701)

Gene Summary

Gene Summary

Gene Information	Gene Name: NDUFA7
	Gene ID: 4701
	Gene Symbol	NDUFA7
	Gene ID	4701
	Gene Name	NADH:ubiquinone oxidoreductase subunit A7
	Synonyms	B14.5a\|CI-B14.5a
	Cytomap	19p13.2
	Type of Gene	protein-coding
	Description	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDaNADH-ubiquinone oxidoreductase subunit B14.5acomplex I B14.5a subunit
	Modification date	20200313
	UniProtAcc	O95182

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0032543	Mitochondrial translation
GO:0005840	Ribosome
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene

Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25

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Translation Studies in PubMed

We searched PubMed using 'NDUFA7[title] AND translation [title] AND human.'

Gene	Title	PMID
NDUFA7	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000301457	8381379	8381529	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000301457	8381379	8381529	618	140	289	113	34	83

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
O95182	34	83	2	113	Chain	ID=PRO_0000118834;Note=NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7
O95182	34	83	40	40	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q9Z1P6
O95182	34	83	66	66	Natural variant	ID=VAR_050589;Note=P->A;Dbxref=dbSNP:rs2288415
O95182	34	83	54	57	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5XTB
O95182	34	83	60	62	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5XTB

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
KICH	NDUFA7	1.53788163726592	0.000102996826171875
BRCA	NDUFA7	-1.54262902945647	2.88710170530718e-14

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
DLBC	NDUFA7	hsa-miR-149-5p	98	0.299722479185939	0.0410928111305565
UCEC	NDUFA7	hsa-miR-24-3p	88	-0.417265087853323	0.0147313049214749

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
SKCM	NDUFA7	-0.037562302	0.026553739
COAD	NDUFA7	0.014217895	0.035611772

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with NDUFA7 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	Cell metabolism gene	NDUFA7	TIMM44	0.803010455	3.22E-11
DLBC	Cell metabolism gene	NDUFA7	GEMIN7	0.801706537	7.55E-12
DLBC	Cell metabolism gene	NDUFA7	SNRPD3	0.807641662	4.02E-12
DLBC	Cell metabolism gene	NDUFA7	PSMD13	0.808178592	3.79E-12
DLBC	Cell metabolism gene	NDUFA7	FAU	0.810697822	2.88E-12
DLBC	Cell metabolism gene	NDUFA7	PSMB7	0.81500892	1.78E-12
DLBC	Cell metabolism gene	NDUFA7	PMPCA	0.820409855	9.60E-13
DLBC	Cell metabolism gene	NDUFA7	TIMM8B	0.82149301	8.46E-13
DLBC	Cell metabolism gene	NDUFA7	TOMM22	0.83399779	1.84E-13
DLBC	Cell metabolism gene	NDUFA7	POLR2F	0.841100457	7.28E-14
DLBC	Cell metabolism gene	NDUFA7	POLR2L	0.841803962	6.63E-14
DLBC	Cell metabolism gene	NDUFA7	SNRPD2	0.842810767	5.79E-14
DLBC	Cell metabolism gene	NDUFA7	NME2	0.846280762	3.60E-14
DLBC	Cell metabolism gene	NDUFA7	PFDN4	0.846885851	3.31E-14
DLBC	Cell metabolism gene	NDUFA7	TIMM13	0.853921105	1.22E-14
DLBC	CGC	NDUFA7	HRAS	0.830110128	2.99E-13
DLBC	Epifactor	NDUFA7	RBX1	0.820021104	1.00E-12
DLBC	IUPHAR	NDUFA7	HRAS	0.830110128	2.99E-13
DLBC	TF	NDUFA7	THAP4	0.806414598	4.59E-12
DLBC	TF	NDUFA7	NME2	0.846280762	3.60E-14
DLBC	TSG	NDUFA7	GADD45GIP1	0.838003032	1.10E-13
DLBC	TSG	NDUFA7	PARK7	0.862048996	3.57E-15
GBM	Cell metabolism gene	NDUFA7	POLR2I	0.80473942	2.38E-40
GBM	Cell metabolism gene	NDUFA7	GPX4	0.811540462	1.60E-41
GBM	Cell metabolism gene	NDUFA7	PSMB3	0.815005317	3.86E-42
GBM	Cell metabolism gene	NDUFA7	TIMM8B	0.824029857	8.30E-44
GBM	TSG	NDUFA7	GADD45GIP1	0.823347822	1.12E-43
KICH	Cell metabolism gene	NDUFA7	GSTK1	0.813617448	1.13E-22
KICH	Cell metabolism gene	NDUFA7	TIMM50	0.820203889	2.65E-23
KICH	Cell metabolism gene	NDUFA7	TIMM13	0.885915081	1.93E-31
KICH	IUPHAR	NDUFA7	ATP6V0B	0.810366089	2.25E-22
KICH	IUPHAR	NDUFA7	ATP6V1F	0.846072557	4.79E-26
KIRP	Cell metabolism gene	NDUFA7	FAU	0.801170888	1.47E-73
KIRP	Cell metabolism gene	NDUFA7	POLR2I	0.867851488	1.55E-99
KIRP	TSG	NDUFA7	GADD45GIP1	0.872444141	7.83E-102
MESO	Cell metabolism gene	NDUFA7	TIMM13	0.818612583	3.55E-22
PCPG	Cell metabolism gene	NDUFA7	POLR2J	0.821856645	4.42E-47
PCPG	CGC	NDUFA7	COX6C	0.817854695	2.83E-46
PCPG	TSG	NDUFA7	GADD45GIP1	0.844337362	5.10E-52
PRAD	Cell metabolism gene	NDUFA7	SNRPD2	0.800324054	7.66E-124
PRAD	Cell metabolism gene	NDUFA7	FAU	0.801536744	1.73E-124
PRAD	Cell metabolism gene	NDUFA7	NME3	0.801794688	1.26E-124
PRAD	Cell metabolism gene	NDUFA7	PSMB3	0.803452124	1.62E-125
PRAD	Cell metabolism gene	NDUFA7	POLR2J	0.811531149	5.53E-130
PRAD	Cell metabolism gene	NDUFA7	HSD17B10	0.814226266	1.60E-131
PRAD	Cell metabolism gene	NDUFA7	ATP5G1	0.814843341	7.06E-132
PRAD	Cell metabolism gene	NDUFA7	DGUOK	0.815644794	2.42E-132
PRAD	Cell metabolism gene	NDUFA7	PSMB7	0.818018225	9.93E-134
PRAD	Cell metabolism gene	NDUFA7	GPX4	0.819514314	1.29E-134
PRAD	Cell metabolism gene	NDUFA7	PFDN6	0.83078259	1.48E-141
PRAD	Cell metabolism gene	NDUFA7	POLR2I	0.83324098	3.85E-143
PRAD	Cell metabolism gene	NDUFA7	POLR2F	0.839432404	3.03E-147
PRAD	Cell metabolism gene	NDUFA7	DPM3	0.839447096	2.96E-147
PRAD	Cell metabolism gene	NDUFA7	TIMM17B	0.854601168	4.39E-158
PRAD	Epifactor	NDUFA7	RBX1	0.803704743	1.18E-125
PRAD	Epifactor	NDUFA7	ZNHIT1	0.805229652	1.76E-126
PRAD	Epifactor	NDUFA7	TAF10	0.824380303	1.49E-137
PRAD	IUPHAR	NDUFA7	CSNK2B	0.803768446	1.09E-125
PRAD	TSG	NDUFA7	PARK7	0.804390343	5.03E-126
PRAD	TSG	NDUFA7	GADD45GIP1	0.856039088	3.56E-159
TGCT	Cell metabolism gene	NDUFA7	SNRPD2	0.804962516	9.71E-37
TGCT	Cell metabolism gene	NDUFA7	POLR2I	0.825977859	3.56E-40
TGCT	TSG	NDUFA7	GADD45GIP1	0.834725758	9.58E-42
THCA	Cell metabolism gene	NDUFA7	GAMT	0.802516039	5.90E-130
THCA	Cell metabolism gene	NDUFA7	PHPT1	0.805959575	6.73E-132
THCA	Cell metabolism gene	NDUFA7	TIMM50	0.806413433	3.71E-132
THCA	Cell metabolism gene	NDUFA7	HAGH	0.808723918	1.74E-133
THCA	Cell metabolism gene	NDUFA7	PSMB3	0.810774828	1.11E-134
THCA	Cell metabolism gene	NDUFA7	PFDN5	0.823137769	3.29E-142
THCA	Cell metabolism gene	NDUFA7	DPM3	0.826291832	3.18E-144
THCA	Cell metabolism gene	NDUFA7	PFDN6	0.828984324	5.62E-146
THCA	Cell metabolism gene	NDUFA7	TIMM13	0.829053456	5.07E-146
THCA	Cell metabolism gene	NDUFA7	POLR2I	0.835236448	3.63E-150
THCA	Cell metabolism gene	NDUFA7	MED11	0.837441657	1.09E-151
THCA	Cell metabolism gene	NDUFA7	COX17	0.842654154	2.25E-155
THCA	Cell metabolism gene	NDUFA7	POLR2J	0.877437394	5.35E-184
THCA	CGC	NDUFA7	COX6C	0.833617785	4.58E-149
THCA	Epifactor	NDUFA7	ZNHIT1	0.832031683	5.36E-148
THCA	IUPHAR	NDUFA7	ATP6V1F	0.806656311	2.69E-132
THCA	IUPHAR	NDUFA7	PPIA	0.81517236	2.71E-137
THCA	TSG	NDUFA7	GABARAP	0.801404151	2.46E-129
THCA	TSG	NDUFA7	GADD45GIP1	0.835564104	2.16E-150
THYM	Cell metabolism gene	NDUFA7	DHRS4	0.801747694	1.35E-28
THYM	Cell metabolism gene	NDUFA7	HMOX2	0.804296828	6.74E-29
THYM	Cell metabolism gene	NDUFA7	PCYT2	0.804688951	6.05E-29
THYM	Cell metabolism gene	NDUFA7	PFDN4	0.804751317	5.95E-29
THYM	Cell metabolism gene	NDUFA7	PFDN2	0.804758079	5.93E-29
THYM	Cell metabolism gene	NDUFA7	PMPCA	0.805924134	4.30E-29
THYM	Cell metabolism gene	NDUFA7	TOMM5	0.807625302	2.68E-29
THYM	Cell metabolism gene	NDUFA7	TAZ	0.807690687	2.63E-29
THYM	Cell metabolism gene	NDUFA7	PSME1	0.809344534	1.65E-29
THYM	Cell metabolism gene	NDUFA7	PPOX	0.810713911	1.12E-29
THYM	Cell metabolism gene	NDUFA7	LCMT1	0.812290928	7.12E-30
THYM	Cell metabolism gene	NDUFA7	POLR3K	0.812816289	6.12E-30
THYM	Cell metabolism gene	NDUFA7	MED27	0.815307219	2.97E-30
THYM	Cell metabolism gene	NDUFA7	UROD	0.815667955	2.67E-30
THYM	Cell metabolism gene	NDUFA7	DHRS4L2	0.815872618	2.51E-30
THYM	Cell metabolism gene	NDUFA7	SRM	0.818510345	1.15E-30
THYM	Cell metabolism gene	NDUFA7	MVD	0.818681736	1.09E-30
THYM	Cell metabolism gene	NDUFA7	UROS	0.819451445	8.67E-31
THYM	Cell metabolism gene	NDUFA7	HMBS	0.821427642	4.77E-31
THYM	Cell metabolism gene	NDUFA7	NME1	0.823624481	2.43E-31
THYM	Cell metabolism gene	NDUFA7	SMPD2	0.824563771	1.82E-31
THYM	Cell metabolism gene	NDUFA7	OAZ1	0.825242106	1.47E-31
THYM	Cell metabolism gene	NDUFA7	POLD2	0.826018046	1.16E-31
THYM	Cell metabolism gene	NDUFA7	IDH3G	0.827160264	8.08E-32
THYM	Cell metabolism gene	NDUFA7	PFDN5	0.830821808	2.51E-32
THYM	Cell metabolism gene	NDUFA7	PSMC5	0.830968989	2.39E-32
THYM	Cell metabolism gene	NDUFA7	PSMC4	0.832545163	1.43E-32
THYM	Cell metabolism gene	NDUFA7	DGAT1	0.832673087	1.38E-32
THYM	Cell metabolism gene	NDUFA7	DPM2	0.835546351	5.33E-33
THYM	Cell metabolism gene	NDUFA7	SNRPD1	0.838139501	2.23E-33
THYM	Cell metabolism gene	NDUFA7	NANS	0.838432191	2.02E-33
THYM	Cell metabolism gene	NDUFA7	SNRPE	0.841211495	7.77E-34
THYM	Cell metabolism gene	NDUFA7	LSM5	0.841646395	6.68E-34
THYM	Cell metabolism gene	NDUFA7	GALK1	0.842019019	5.87E-34
THYM	Cell metabolism gene	NDUFA7	TOMM22	0.848957444	4.93E-35
THYM	Cell metabolism gene	NDUFA7	DTYMK	0.849254506	4.42E-35
THYM	Cell metabolism gene	NDUFA7	PSMB1	0.849936409	3.44E-35
THYM	Cell metabolism gene	NDUFA7	TSTA3	0.851220338	2.14E-35
THYM	Cell metabolism gene	NDUFA7	LSM2	0.852943345	1.12E-35
THYM	Cell metabolism gene	NDUFA7	ATP5G1	0.855982358	3.52E-36
THYM	Cell metabolism gene	NDUFA7	EXOSC1	0.856193253	3.25E-36
THYM	Cell metabolism gene	NDUFA7	PSMC1	0.856931178	2.44E-36
THYM	Cell metabolism gene	NDUFA7	SEC61G	0.857967777	1.63E-36
THYM	Cell metabolism gene	NDUFA7	FAU	0.858046472	1.58E-36
THYM	Cell metabolism gene	NDUFA7	POLR2F	0.858661628	1.24E-36
THYM	Cell metabolism gene	NDUFA7	GSS	0.858731114	1.21E-36
THYM	Cell metabolism gene	NDUFA7	SEC61B	0.860347943	6.37E-37
THYM	Cell metabolism gene	NDUFA7	EXOSC5	0.860778096	5.36E-37
THYM	Cell metabolism gene	NDUFA7	COX17	0.86315642	2.05E-37
THYM	Cell metabolism gene	NDUFA7	MIF	0.863411742	1.85E-37
THYM	Cell metabolism gene	NDUFA7	SNRPD3	0.864466054	1.20E-37
THYM	Cell metabolism gene	NDUFA7	LSM3	0.865470822	7.93E-38
THYM	Cell metabolism gene	NDUFA7	ITPA	0.865530413	7.74E-38
THYM	Cell metabolism gene	NDUFA7	PSMA4	0.867815334	2.97E-38
THYM	Cell metabolism gene	NDUFA7	SNRPB	0.867985439	2.76E-38
THYM	Cell metabolism gene	NDUFA7	GEMIN6	0.869860773	1.24E-38
THYM	Cell metabolism gene	NDUFA7	TIMM10	0.869898444	1.22E-38
THYM	Cell metabolism gene	NDUFA7	PSMB4	0.870697182	8.65E-39
THYM	Cell metabolism gene	NDUFA7	PGP	0.870953949	7.74E-39
THYM	Cell metabolism gene	NDUFA7	SNRPF	0.874057904	1.98E-39
THYM	Cell metabolism gene	NDUFA7	SLC27A5	0.876020347	8.19E-40
THYM	Cell metabolism gene	NDUFA7	GEMIN7	0.876557994	6.41E-40
THYM	Cell metabolism gene	NDUFA7	PSMD13	0.877440448	4.29E-40
THYM	Cell metabolism gene	NDUFA7	PSME2	0.877502825	4.16E-40
THYM	Cell metabolism gene	NDUFA7	TXN	0.87834475	2.83E-40
THYM	Cell metabolism gene	NDUFA7	EXOSC4	0.878875861	2.21E-40
THYM	Cell metabolism gene	NDUFA7	PFDN6	0.880256426	1.16E-40
THYM	Cell metabolism gene	NDUFA7	HSD17B10	0.882952353	3.21E-41
THYM	Cell metabolism gene	NDUFA7	PSMB6	0.887173529	4.04E-42
THYM	Cell metabolism gene	NDUFA7	PAFAH1B3	0.890684476	6.74E-43
THYM	Cell metabolism gene	NDUFA7	PSMB10	0.890910382	6.00E-43
THYM	Cell metabolism gene	NDUFA7	PSMC3	0.893065175	1.94E-43
THYM	Cell metabolism gene	NDUFA7	PGLS	0.893770447	1.33E-43
THYM	Cell metabolism gene	NDUFA7	MTX1	0.89426416	1.02E-43
THYM	Cell metabolism gene	NDUFA7	POLR2H	0.895060786	6.64E-44
THYM	Cell metabolism gene	NDUFA7	WBSCR22	0.898283418	1.13E-44
THYM	Cell metabolism gene	NDUFA7	DPM3	0.900169503	3.89E-45
THYM	Cell metabolism gene	NDUFA7	PSMD4	0.900257721	3.70E-45
THYM	Cell metabolism gene	NDUFA7	TBCB	0.902279736	1.15E-45
THYM	Cell metabolism gene	NDUFA7	TIMM13	0.903007891	7.51E-46
THYM	Cell metabolism gene	NDUFA7	PSMB7	0.907410442	5.29E-47
THYM	Cell metabolism gene	NDUFA7	PHKG2	0.910641252	6.92E-48
THYM	Cell metabolism gene	NDUFA7	DGUOK	0.910807	6.23E-48
THYM	Cell metabolism gene	NDUFA7	EBP	0.912206046	2.52E-48
THYM	Cell metabolism gene	NDUFA7	TIMM17B	0.912514319	2.06E-48
THYM	Cell metabolism gene	NDUFA7	APRT	0.916320124	1.60E-49
THYM	Cell metabolism gene	NDUFA7	TIMM8B	0.920682653	7.35E-51
THYM	Cell metabolism gene	NDUFA7	GUK1	0.921280415	4.75E-51
THYM	Cell metabolism gene	NDUFA7	TOMM40	0.922327851	2.20E-51
THYM	Cell metabolism gene	NDUFA7	ACOT8	0.922728469	1.63E-51
THYM	Cell metabolism gene	NDUFA7	POLR2I	0.92473731	3.56E-52
THYM	Cell metabolism gene	NDUFA7	TIMM50	0.932181434	8.61E-55
THYM	Cell metabolism gene	NDUFA7	SNRPD2	0.932237732	8.21E-55
THYM	Cell metabolism gene	NDUFA7	LSM4	0.934126798	1.59E-55
THYM	Cell metabolism gene	NDUFA7	POLR2J	0.936383338	2.10E-56
THYM	Cell metabolism gene	NDUFA7	PSMB3	0.947264331	3.77E-61
THYM	CGC	NDUFA7	MAP2K2	0.812330107	7.04E-30
THYM	CGC	NDUFA7	MGMT	0.812685382	6.36E-30
THYM	CGC	NDUFA7	RBM10	0.827273004	7.80E-32
THYM	CGC	NDUFA7	SDHAF2	0.853783904	8.17E-36
THYM	CGC	NDUFA7	TFPT	0.893123318	1.88E-43
THYM	CGC	NDUFA7	COX6C	0.902090936	1.28E-45
THYM	Epifactor	NDUFA7	MBD3	0.806757836	3.41E-29
THYM	Epifactor	NDUFA7	PPM1G	0.809326325	1.66E-29
THYM	Epifactor	NDUFA7	PRMT1	0.811425306	9.13E-30
THYM	Epifactor	NDUFA7	FBL	0.820059213	7.22E-31
THYM	Epifactor	NDUFA7	SS18L2	0.834434991	7.70E-33
THYM	Epifactor	NDUFA7	HMG20B	0.834556899	7.40E-33
THYM	Epifactor	NDUFA7	RBX1	0.837325484	2.93E-33
THYM	Epifactor	NDUFA7	LAS1L	0.846108743	1.38E-34
THYM	Epifactor	NDUFA7	HIST2H2AC	0.846916579	1.03E-34
THYM	Epifactor	NDUFA7	PAF1	0.850283902	3.03E-35
THYM	Epifactor	NDUFA7	EXOSC1	0.856193253	3.25E-36
THYM	Epifactor	NDUFA7	ZGPAT	0.856955403	2.42E-36
THYM	Epifactor	NDUFA7	C17orf49	0.859229977	9.92E-37
THYM	Epifactor	NDUFA7	EXOSC5	0.860778096	5.36E-37
THYM	Epifactor	NDUFA7	CCDC101	0.864323427	1.27E-37
THYM	Epifactor	NDUFA7	EXOSC4	0.878875861	2.21E-40
THYM	Epifactor	NDUFA7	CDK5	0.879409578	1.72E-40
THYM	Epifactor	NDUFA7	INO80E	0.889628486	1.16E-42
THYM	Epifactor	NDUFA7	TFPT	0.893123318	1.88E-43
THYM	Epifactor	NDUFA7	PPP4C	0.893780028	1.32E-43
THYM	Epifactor	NDUFA7	RUVBL2	0.899971374	4.35E-45
THYM	Epifactor	NDUFA7	PRPF31	0.907122122	6.32E-47
THYM	Epifactor	NDUFA7	BRMS1	0.913908102	8.18E-49
THYM	Epifactor	NDUFA7	SIRT6	0.921900746	3.01E-51
THYM	Epifactor	NDUFA7	TAF10	0.929880379	5.95E-54
THYM	Epifactor	NDUFA7	ZNHIT1	0.938213752	3.86E-57
THYM	IUPHAR	NDUFA7	HMOX2	0.804296828	6.74E-29
THYM	IUPHAR	NDUFA7	PRMT1	0.811425306	9.13E-30
THYM	IUPHAR	NDUFA7	MAP2K2	0.812330107	7.04E-30
THYM	IUPHAR	NDUFA7	MPDU1	0.813028521	5.76E-30
THYM	IUPHAR	NDUFA7	MVD	0.818681736	1.09E-30
THYM	IUPHAR	NDUFA7	SMPD2	0.824563771	1.82E-31
THYM	IUPHAR	NDUFA7	SLC39A3	0.824611485	1.79E-31
THYM	IUPHAR	NDUFA7	ATG4B	0.828627607	5.08E-32
THYM	IUPHAR	NDUFA7	DGAT1	0.832673087	1.38E-32
THYM	IUPHAR	NDUFA7	ADCK5	0.839453257	1.42E-33
THYM	IUPHAR	NDUFA7	DYRK4	0.840381141	1.04E-33
THYM	IUPHAR	NDUFA7	MMP24	0.841812921	6.31E-34
THYM	IUPHAR	NDUFA7	PSMB1	0.849936409	3.44E-35
THYM	IUPHAR	NDUFA7	SLC27A5	0.876020347	8.19E-40
THYM	IUPHAR	NDUFA7	CDK5	0.879409578	1.72E-40
THYM	IUPHAR	NDUFA7	PSMB6	0.887173529	4.04E-42
THYM	IUPHAR	NDUFA7	PPIA	0.907728166	4.34E-47
THYM	IUPHAR	NDUFA7	PHKG2	0.910641252	6.92E-48
THYM	IUPHAR	NDUFA7	SIRT6	0.921900746	3.01E-51
THYM	Kinase	NDUFA7	ADCK4	0.805037176	5.50E-29
THYM	Kinase	NDUFA7	FASTK	0.808930139	1.86E-29
THYM	Kinase	NDUFA7	MAP2K2	0.812330107	7.04E-30
THYM	Kinase	NDUFA7	ADCK5	0.839453257	1.42E-33
THYM	Kinase	NDUFA7	DYRK4	0.840381141	1.04E-33
THYM	Kinase	NDUFA7	CDK5	0.879409578	1.72E-40
THYM	Kinase	NDUFA7	PHKG2	0.910641252	6.92E-48
THYM	TF	NDUFA7	ZNF653	0.805113398	5.38E-29
THYM	TF	NDUFA7	MBD3	0.806757836	3.41E-29
THYM	TF	NDUFA7	THAP3	0.809177613	1.73E-29
THYM	TF	NDUFA7	ZNF524	0.809785179	1.46E-29
THYM	TF	NDUFA7	MYPOP	0.810726793	1.11E-29
THYM	TF	NDUFA7	ZNF511	0.814637117	3.61E-30
THYM	TF	NDUFA7	SNAPC2	0.815623949	2.70E-30
THYM	TF	NDUFA7	AKAP8L	0.81611037	2.34E-30
THYM	TF	NDUFA7	THAP7	0.820068172	7.20E-31
THYM	TF	NDUFA7	THAP8	0.823847906	2.27E-31
THYM	TF	NDUFA7	PIN1	0.828780745	4.83E-32
THYM	TF	NDUFA7	IRF3	0.830902311	2.45E-32
THYM	TF	NDUFA7	GTF3A	0.831113602	2.28E-32
THYM	TF	NDUFA7	HMG20B	0.834556899	7.40E-33
THYM	TF	NDUFA7	ZNF32	0.844704322	2.28E-34
THYM	TF	NDUFA7	ETV2	0.844817592	2.19E-34
THYM	TF	NDUFA7	DNTTIP1	0.844865224	2.16E-34
THYM	TF	NDUFA7	THYN1	0.846105037	1.39E-34
THYM	TF	NDUFA7	USF1	0.851114493	2.22E-35
THYM	TF	NDUFA7	ZNF444	0.855981207	3.53E-36
THYM	TF	NDUFA7	ZGPAT	0.856955403	2.42E-36
THYM	TF	NDUFA7	ZNF668	0.858949636	1.11E-36
THYM	TF	NDUFA7	RBCK1	0.863491013	1.79E-37
THYM	TF	NDUFA7	ZNF428	0.873857888	2.16E-39
THYM	TF	NDUFA7	ZNF688	0.883145055	2.93E-41
THYM	TF	NDUFA7	GLI4	0.884419782	1.58E-41
THYM	TF	NDUFA7	ZNF787	0.895849026	4.33E-44
THYM	TF	NDUFA7	DRAP1	0.922720814	1.64E-51
THYM	TSG	NDUFA7	NME1	0.823624481	2.43E-31
THYM	TSG	NDUFA7	ST20	0.823719071	2.36E-31
THYM	TSG	NDUFA7	PIN1	0.828780745	4.83E-32
THYM	TSG	NDUFA7	IRF3	0.830902311	2.45E-32
THYM	TSG	NDUFA7	GNB2L1	0.834314327	8.02E-33
THYM	TSG	NDUFA7	PFN1	0.838794639	1.78E-33
THYM	TSG	NDUFA7	GABARAP	0.840811013	8.93E-34
THYM	TSG	NDUFA7	MAD1L1	0.846146648	1.36E-34
THYM	TSG	NDUFA7	HTRA2	0.848276343	6.32E-35
THYM	TSG	NDUFA7	TSSC4	0.852586463	1.28E-35
THYM	TSG	NDUFA7	PARK7	0.855645633	4.01E-36
THYM	TSG	NDUFA7	ZNF668	0.858949636	1.11E-36
THYM	TSG	NDUFA7	NPRL2	0.876976481	5.30E-40
THYM	TSG	NDUFA7	BRMS1	0.913908102	8.18E-49
THYM	TSG	NDUFA7	GADD45GIP1	0.918755308	2.93E-50
THYM	TSG	NDUFA7	SIRT6	0.921900746	3.01E-51
UCS	Cell metabolism gene	NDUFA7	DHRS4	0.801747694	1.35E-28
UCS	Cell metabolism gene	NDUFA7	HMOX2	0.804296828	6.74E-29
UCS	Cell metabolism gene	NDUFA7	PCYT2	0.804688951	6.05E-29
UCS	Cell metabolism gene	NDUFA7	PFDN4	0.804751317	5.95E-29
UCS	Cell metabolism gene	NDUFA7	PFDN2	0.804758079	5.93E-29
UCS	Cell metabolism gene	NDUFA7	PMPCA	0.805924134	4.30E-29
UCS	Cell metabolism gene	NDUFA7	TOMM5	0.807625302	2.68E-29
UCS	Cell metabolism gene	NDUFA7	TAZ	0.807690687	2.63E-29
UCS	Cell metabolism gene	NDUFA7	PSME1	0.809344534	1.65E-29
UCS	Cell metabolism gene	NDUFA7	PPOX	0.810713911	1.12E-29
UCS	Cell metabolism gene	NDUFA7	LCMT1	0.812290928	7.12E-30
UCS	Cell metabolism gene	NDUFA7	POLR3K	0.812816289	6.12E-30
UCS	Cell metabolism gene	NDUFA7	MED27	0.815307219	2.97E-30
UCS	Cell metabolism gene	NDUFA7	UROD	0.815667955	2.67E-30
UCS	Cell metabolism gene	NDUFA7	DHRS4L2	0.815872618	2.51E-30
UCS	Cell metabolism gene	NDUFA7	SRM	0.818510345	1.15E-30
UCS	Cell metabolism gene	NDUFA7	MVD	0.818681736	1.09E-30
UCS	Cell metabolism gene	NDUFA7	UROS	0.819451445	8.67E-31
UCS	Cell metabolism gene	NDUFA7	HMBS	0.821427642	4.77E-31
UCS	Cell metabolism gene	NDUFA7	NME1	0.823624481	2.43E-31
UCS	Cell metabolism gene	NDUFA7	SMPD2	0.824563771	1.82E-31
UCS	Cell metabolism gene	NDUFA7	OAZ1	0.825242106	1.47E-31
UCS	Cell metabolism gene	NDUFA7	POLD2	0.826018046	1.16E-31
UCS	Cell metabolism gene	NDUFA7	IDH3G	0.827160264	8.08E-32
UCS	Cell metabolism gene	NDUFA7	PFDN5	0.830821808	2.51E-32
UCS	Cell metabolism gene	NDUFA7	PSMC5	0.830968989	2.39E-32
UCS	Cell metabolism gene	NDUFA7	PSMC4	0.832545163	1.43E-32
UCS	Cell metabolism gene	NDUFA7	DGAT1	0.832673087	1.38E-32
UCS	Cell metabolism gene	NDUFA7	DPM2	0.835546351	5.33E-33
UCS	Cell metabolism gene	NDUFA7	SNRPD1	0.838139501	2.23E-33
UCS	Cell metabolism gene	NDUFA7	NANS	0.838432191	2.02E-33
UCS	Cell metabolism gene	NDUFA7	SNRPE	0.841211495	7.77E-34
UCS	Cell metabolism gene	NDUFA7	LSM5	0.841646395	6.68E-34
UCS	Cell metabolism gene	NDUFA7	GALK1	0.842019019	5.87E-34
UCS	Cell metabolism gene	NDUFA7	TOMM22	0.848957444	4.93E-35
UCS	Cell metabolism gene	NDUFA7	DTYMK	0.849254506	4.42E-35
UCS	Cell metabolism gene	NDUFA7	PSMB1	0.849936409	3.44E-35
UCS	Cell metabolism gene	NDUFA7	TSTA3	0.851220338	2.14E-35
UCS	Cell metabolism gene	NDUFA7	LSM2	0.852943345	1.12E-35
UCS	Cell metabolism gene	NDUFA7	ATP5G1	0.855982358	3.52E-36
UCS	Cell metabolism gene	NDUFA7	EXOSC1	0.856193253	3.25E-36
UCS	Cell metabolism gene	NDUFA7	PSMC1	0.856931178	2.44E-36
UCS	Cell metabolism gene	NDUFA7	SEC61G	0.857967777	1.63E-36
UCS	Cell metabolism gene	NDUFA7	FAU	0.858046472	1.58E-36
UCS	Cell metabolism gene	NDUFA7	POLR2F	0.858661628	1.24E-36
UCS	Cell metabolism gene	NDUFA7	GSS	0.858731114	1.21E-36
UCS	Cell metabolism gene	NDUFA7	SEC61B	0.860347943	6.37E-37
UCS	Cell metabolism gene	NDUFA7	EXOSC5	0.860778096	5.36E-37
UCS	Cell metabolism gene	NDUFA7	COX17	0.86315642	2.05E-37
UCS	Cell metabolism gene	NDUFA7	MIF	0.863411742	1.85E-37
UCS	Cell metabolism gene	NDUFA7	SNRPD3	0.864466054	1.20E-37
UCS	Cell metabolism gene	NDUFA7	LSM3	0.865470822	7.93E-38
UCS	Cell metabolism gene	NDUFA7	ITPA	0.865530413	7.74E-38
UCS	Cell metabolism gene	NDUFA7	PSMA4	0.867815334	2.97E-38
UCS	Cell metabolism gene	NDUFA7	SNRPB	0.867985439	2.76E-38
UCS	Cell metabolism gene	NDUFA7	GEMIN6	0.869860773	1.24E-38
UCS	Cell metabolism gene	NDUFA7	TIMM10	0.869898444	1.22E-38
UCS	Cell metabolism gene	NDUFA7	PSMB4	0.870697182	8.65E-39
UCS	Cell metabolism gene	NDUFA7	PGP	0.870953949	7.74E-39
UCS	Cell metabolism gene	NDUFA7	SNRPF	0.874057904	1.98E-39
UCS	Cell metabolism gene	NDUFA7	SLC27A5	0.876020347	8.19E-40
UCS	Cell metabolism gene	NDUFA7	GEMIN7	0.876557994	6.41E-40
UCS	Cell metabolism gene	NDUFA7	PSMD13	0.877440448	4.29E-40
UCS	Cell metabolism gene	NDUFA7	PSME2	0.877502825	4.16E-40
UCS	Cell metabolism gene	NDUFA7	TXN	0.87834475	2.83E-40
UCS	Cell metabolism gene	NDUFA7	EXOSC4	0.878875861	2.21E-40
UCS	Cell metabolism gene	NDUFA7	PFDN6	0.880256426	1.16E-40
UCS	Cell metabolism gene	NDUFA7	HSD17B10	0.882952353	3.21E-41
UCS	Cell metabolism gene	NDUFA7	PSMB6	0.887173529	4.04E-42
UCS	Cell metabolism gene	NDUFA7	PAFAH1B3	0.890684476	6.74E-43
UCS	Cell metabolism gene	NDUFA7	PSMB10	0.890910382	6.00E-43
UCS	Cell metabolism gene	NDUFA7	PSMC3	0.893065175	1.94E-43
UCS	Cell metabolism gene	NDUFA7	PGLS	0.893770447	1.33E-43
UCS	Cell metabolism gene	NDUFA7	MTX1	0.89426416	1.02E-43
UCS	Cell metabolism gene	NDUFA7	POLR2H	0.895060786	6.64E-44
UCS	Cell metabolism gene	NDUFA7	WBSCR22	0.898283418	1.13E-44
UCS	Cell metabolism gene	NDUFA7	DPM3	0.900169503	3.89E-45
UCS	Cell metabolism gene	NDUFA7	PSMD4	0.900257721	3.70E-45
UCS	Cell metabolism gene	NDUFA7	TBCB	0.902279736	1.15E-45
UCS	Cell metabolism gene	NDUFA7	TIMM13	0.903007891	7.51E-46
UCS	Cell metabolism gene	NDUFA7	PSMB7	0.907410442	5.29E-47
UCS	Cell metabolism gene	NDUFA7	PHKG2	0.910641252	6.92E-48
UCS	Cell metabolism gene	NDUFA7	DGUOK	0.910807	6.23E-48
UCS	Cell metabolism gene	NDUFA7	EBP	0.912206046	2.52E-48
UCS	Cell metabolism gene	NDUFA7	TIMM17B	0.912514319	2.06E-48
UCS	Cell metabolism gene	NDUFA7	APRT	0.916320124	1.60E-49
UCS	Cell metabolism gene	NDUFA7	TIMM8B	0.920682653	7.35E-51
UCS	Cell metabolism gene	NDUFA7	GUK1	0.921280415	4.75E-51
UCS	Cell metabolism gene	NDUFA7	TOMM40	0.922327851	2.20E-51
UCS	Cell metabolism gene	NDUFA7	ACOT8	0.922728469	1.63E-51
UCS	Cell metabolism gene	NDUFA7	POLR2I	0.92473731	3.56E-52
UCS	Cell metabolism gene	NDUFA7	TIMM50	0.932181434	8.61E-55
UCS	Cell metabolism gene	NDUFA7	SNRPD2	0.932237732	8.21E-55
UCS	Cell metabolism gene	NDUFA7	LSM4	0.934126798	1.59E-55
UCS	Cell metabolism gene	NDUFA7	POLR2J	0.936383338	2.10E-56
UCS	Cell metabolism gene	NDUFA7	PSMB3	0.947264331	3.77E-61
UCS	CGC	NDUFA7	MAP2K2	0.812330107	7.04E-30
UCS	CGC	NDUFA7	MGMT	0.812685382	6.36E-30
UCS	CGC	NDUFA7	RBM10	0.827273004	7.80E-32
UCS	CGC	NDUFA7	SDHAF2	0.853783904	8.17E-36
UCS	CGC	NDUFA7	TFPT	0.893123318	1.88E-43
UCS	CGC	NDUFA7	COX6C	0.902090936	1.28E-45
UCS	Epifactor	NDUFA7	MBD3	0.806757836	3.41E-29
UCS	Epifactor	NDUFA7	PPM1G	0.809326325	1.66E-29
UCS	Epifactor	NDUFA7	PRMT1	0.811425306	9.13E-30
UCS	Epifactor	NDUFA7	FBL	0.820059213	7.22E-31
UCS	Epifactor	NDUFA7	SS18L2	0.834434991	7.70E-33
UCS	Epifactor	NDUFA7	HMG20B	0.834556899	7.40E-33
UCS	Epifactor	NDUFA7	RBX1	0.837325484	2.93E-33
UCS	Epifactor	NDUFA7	LAS1L	0.846108743	1.38E-34
UCS	Epifactor	NDUFA7	HIST2H2AC	0.846916579	1.03E-34
UCS	Epifactor	NDUFA7	PAF1	0.850283902	3.03E-35
UCS	Epifactor	NDUFA7	EXOSC1	0.856193253	3.25E-36
UCS	Epifactor	NDUFA7	ZGPAT	0.856955403	2.42E-36
UCS	Epifactor	NDUFA7	C17orf49	0.859229977	9.92E-37
UCS	Epifactor	NDUFA7	EXOSC5	0.860778096	5.36E-37
UCS	Epifactor	NDUFA7	CCDC101	0.864323427	1.27E-37
UCS	Epifactor	NDUFA7	EXOSC4	0.878875861	2.21E-40
UCS	Epifactor	NDUFA7	CDK5	0.879409578	1.72E-40
UCS	Epifactor	NDUFA7	INO80E	0.889628486	1.16E-42
UCS	Epifactor	NDUFA7	TFPT	0.893123318	1.88E-43
UCS	Epifactor	NDUFA7	PPP4C	0.893780028	1.32E-43
UCS	Epifactor	NDUFA7	RUVBL2	0.899971374	4.35E-45
UCS	Epifactor	NDUFA7	PRPF31	0.907122122	6.32E-47
UCS	Epifactor	NDUFA7	BRMS1	0.913908102	8.18E-49
UCS	Epifactor	NDUFA7	SIRT6	0.921900746	3.01E-51
UCS	Epifactor	NDUFA7	TAF10	0.929880379	5.95E-54
UCS	Epifactor	NDUFA7	ZNHIT1	0.938213752	3.86E-57
UCS	IUPHAR	NDUFA7	HMOX2	0.804296828	6.74E-29
UCS	IUPHAR	NDUFA7	PRMT1	0.811425306	9.13E-30
UCS	IUPHAR	NDUFA7	MAP2K2	0.812330107	7.04E-30
UCS	IUPHAR	NDUFA7	MPDU1	0.813028521	5.76E-30
UCS	IUPHAR	NDUFA7	MVD	0.818681736	1.09E-30
UCS	IUPHAR	NDUFA7	SMPD2	0.824563771	1.82E-31
UCS	IUPHAR	NDUFA7	SLC39A3	0.824611485	1.79E-31
UCS	IUPHAR	NDUFA7	ATG4B	0.828627607	5.08E-32
UCS	IUPHAR	NDUFA7	DGAT1	0.832673087	1.38E-32
UCS	IUPHAR	NDUFA7	ADCK5	0.839453257	1.42E-33
UCS	IUPHAR	NDUFA7	DYRK4	0.840381141	1.04E-33
UCS	IUPHAR	NDUFA7	MMP24	0.841812921	6.31E-34
UCS	IUPHAR	NDUFA7	PSMB1	0.849936409	3.44E-35
UCS	IUPHAR	NDUFA7	SLC27A5	0.876020347	8.19E-40
UCS	IUPHAR	NDUFA7	CDK5	0.879409578	1.72E-40
UCS	IUPHAR	NDUFA7	PSMB6	0.887173529	4.04E-42
UCS	IUPHAR	NDUFA7	PPIA	0.907728166	4.34E-47
UCS	IUPHAR	NDUFA7	PHKG2	0.910641252	6.92E-48
UCS	IUPHAR	NDUFA7	SIRT6	0.921900746	3.01E-51
UCS	Kinase	NDUFA7	ADCK4	0.805037176	5.50E-29
UCS	Kinase	NDUFA7	FASTK	0.808930139	1.86E-29
UCS	Kinase	NDUFA7	MAP2K2	0.812330107	7.04E-30
UCS	Kinase	NDUFA7	ADCK5	0.839453257	1.42E-33
UCS	Kinase	NDUFA7	DYRK4	0.840381141	1.04E-33
UCS	Kinase	NDUFA7	CDK5	0.879409578	1.72E-40
UCS	Kinase	NDUFA7	PHKG2	0.910641252	6.92E-48
UCS	TF	NDUFA7	ZNF653	0.805113398	5.38E-29
UCS	TF	NDUFA7	MBD3	0.806757836	3.41E-29
UCS	TF	NDUFA7	THAP3	0.809177613	1.73E-29
UCS	TF	NDUFA7	ZNF524	0.809785179	1.46E-29
UCS	TF	NDUFA7	MYPOP	0.810726793	1.11E-29
UCS	TF	NDUFA7	ZNF511	0.814637117	3.61E-30
UCS	TF	NDUFA7	SNAPC2	0.815623949	2.70E-30
UCS	TF	NDUFA7	AKAP8L	0.81611037	2.34E-30
UCS	TF	NDUFA7	THAP7	0.820068172	7.20E-31
UCS	TF	NDUFA7	THAP8	0.823847906	2.27E-31
UCS	TF	NDUFA7	PIN1	0.828780745	4.83E-32
UCS	TF	NDUFA7	IRF3	0.830902311	2.45E-32
UCS	TF	NDUFA7	GTF3A	0.831113602	2.28E-32
UCS	TF	NDUFA7	HMG20B	0.834556899	7.40E-33
UCS	TF	NDUFA7	ZNF32	0.844704322	2.28E-34
UCS	TF	NDUFA7	ETV2	0.844817592	2.19E-34
UCS	TF	NDUFA7	DNTTIP1	0.844865224	2.16E-34
UCS	TF	NDUFA7	THYN1	0.846105037	1.39E-34
UCS	TF	NDUFA7	USF1	0.851114493	2.22E-35
UCS	TF	NDUFA7	ZNF444	0.855981207	3.53E-36
UCS	TF	NDUFA7	ZGPAT	0.856955403	2.42E-36
UCS	TF	NDUFA7	ZNF668	0.858949636	1.11E-36
UCS	TF	NDUFA7	RBCK1	0.863491013	1.79E-37
UCS	TF	NDUFA7	ZNF428	0.873857888	2.16E-39
UCS	TF	NDUFA7	ZNF688	0.883145055	2.93E-41
UCS	TF	NDUFA7	GLI4	0.884419782	1.58E-41
UCS	TF	NDUFA7	ZNF787	0.895849026	4.33E-44
UCS	TF	NDUFA7	DRAP1	0.922720814	1.64E-51
UCS	TSG	NDUFA7	NME1	0.823624481	2.43E-31
UCS	TSG	NDUFA7	ST20	0.823719071	2.36E-31
UCS	TSG	NDUFA7	PIN1	0.828780745	4.83E-32
UCS	TSG	NDUFA7	IRF3	0.830902311	2.45E-32
UCS	TSG	NDUFA7	GNB2L1	0.834314327	8.02E-33
UCS	TSG	NDUFA7	PFN1	0.838794639	1.78E-33
UCS	TSG	NDUFA7	GABARAP	0.840811013	8.93E-34
UCS	TSG	NDUFA7	MAD1L1	0.846146648	1.36E-34
UCS	TSG	NDUFA7	HTRA2	0.848276343	6.32E-35
UCS	TSG	NDUFA7	TSSC4	0.852586463	1.28E-35
UCS	TSG	NDUFA7	PARK7	0.855645633	4.01E-36
UCS	TSG	NDUFA7	ZNF668	0.858949636	1.11E-36
UCS	TSG	NDUFA7	NPRL2	0.876976481	5.30E-40
UCS	TSG	NDUFA7	BRMS1	0.913908102	8.18E-49
UCS	TSG	NDUFA7	GADD45GIP1	0.918755308	2.93E-50
UCS	TSG	NDUFA7	SIRT6	0.921900746	3.01E-51

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KICH	NDUFA7	NDUFB10	1.29322516228535	0.000139892101287842
STAD	NDUFA7	NDUFS7	-4.8324115077958	0.000205773763699815
LUSC	NDUFA7	NDUFS3	-1.58424132085275	0.000209558356255901
COAD	NDUFA7	NDUFB7	-2.04470920379482	0.000248014926910401
KIRC	NDUFA7	NDUFS6	1.04251930125749	0.000332359057458565
HNSC	NDUFA7	NDUFA9	-3.10591909740806	0.00117271471503955
KIRC	NDUFA7	NDUFS7	1.66597899872167	0.00147771672292033
ESCA	NDUFA7	NDUFB10	1.3782178002866	0.0048828125
COAD	NDUFA7	NDUFS6	-1.58119750155931	0.00863465666770936
LUAD	NDUFA7	NDUFB5	-1.03985916617706	0.0116026131528984
THCA	NDUFA7	NDUFB10	-2.79702238016745	0.0137237433303792
BRCA	NDUFA7	NDUFB5	-1.00192395692938	0.016066101715663
STAD	NDUFA7	NDUFB4	-1.85034908110184	0.0240015927702189
KICH	NDUFA7	NDUFS6	1.23745974384438	0.0341737866401672
CHOL	NDUFA7	NDUFA2	-4.83313359916434	0.0390625
CHOL	NDUFA7	NDUFS7	-2.65895796138573	0.0390625
KICH	NDUFA7	NDUFB4	1.0141585413185	0.0451226830482483
BRCA	NDUFA7	NDUFA2	-1.23047816050249	1.4241275831312e-08
LUAD	NDUFA7	NDUFB4	-1.90632952818948	1.49476796821536e-07
COAD	NDUFA7	NDUFA10	-1.92397773933221	2.08616256713867e-06
COAD	NDUFA7	NDUFS7	-2.68835162675926	2.08616256713867e-06
COAD	NDUFA7	NDUFB10	-5.41397019648328	2.08616256713867e-07
LUSC	NDUFA7	NDUFA10	-1.42408689446922	2.71315137313761e-06
COAD	NDUFA7	NDUFS3	-3.42723334467545	3.27825546264649e-06
LUAD	NDUFA7	NDUFS6	-3.19240522959907	3.31565482735716e-09
HNSC	NDUFA7	NDUFA2	2.85918969233935	3.78557160729543e-07
KICH	NDUFA7	NDUFA9	1.26066465730615	4.17232513427734e-06
KIRP	NDUFA7	NDUFS3	-4.88175807476511	5.4334755986929e-05
BRCA	NDUFA7	NDUFB10	-1.78562659925404	5.72592448935784e-11
KICH	NDUFA7	NDUFS7	1.18397263074827	5.96046447753906e-08
BRCA	NDUFA7	NDUFA9	-1.66287934236546	8.17337395878474e-08

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with NDUFA7

PRKAB1, RPL38, TIMM44, RRBP1, PIN1, SBDS, RAB8A, PDLIM5, RBM27, MRRF, TAGLN, PIN4, RANGAP1, UBL4A, PDLIM7, TPX2, UBE2L3, SNX3, ECI2, HRSP12, RBMS1, SUGP1, QKI, PQBP1, KIAA0101, RPS10P5, TBL2, RFX5, STX7, MPLKIP, SNRPC, SCO2, NABP2, MRPS28, ZC3H11A, CDV3, MRPL14, OLA1, SRRM2, TOMM40, RPS28, UBE2I, GATAD2B, UBE4B, VDAC3, SCP2, ACAA1, NUP214, MDFI, UPF2, NDUFS3, TMX2, DNAJC30, GJA1, ENPP6, NDUFA8, VAPB, NDUFA12, NDUFS4, NDUFS5, NDUFA9, NDUFS6, RAB5C, RAB7A, VAPA, GOLT1B, MMGT1, Bmpr1a, C1qbp, Rab5c, Tmed2, Rmdn3, NDUFA4, C15orf48, COX6B1, NDUFB11, NDUFS7, NDUFA13, SSMEM1, FUT1, MRM1, SCO1, HSPD1, PDK1, COX14, TRMT61B, AURKAIP1, CYB5A, ATP5H, SLC25A24, BCAP31, ARMCX2, ATP5B, COX6A1, NDUFB10, NDUFB9, LMBR1L, TTPA, LMO1, RTP2, PLEKHA4, CAPZB, NDUFA5, ESR1, HSCB, GRSF1, ACAD9, AUH, C12orf65, C17orf80, C1QBP, C21orf33, C6orf203, C8orf82, MCUR1, CCDC90B, CHCHD1, COX15, CS, DDX28, FASTKD2, FASTKD3, FASTKD5, GFM1, GFM2, HINT2, ICT1, LONP1, LRPPRC, MCU, CCDC109B, MDH2, METTL15, METTL17, MRPL11, MRPS12, MRPS26, MTERF3, MTG2, MTIF2, MTIF3, MTRF1, MTRF1L, NGRN, OTC, PMPCA, PMPCB, RPUSD3, RPUSD4, SLC25A51, SLIRP, SSBP1, SURF1, TACO1, TBRG4, TEFM, TFAM, TMEM70, TRUB2, TSFM, TUFM, VWA8, EXD2, BCAR1, CLPP, INS, DNAJA3, DNAJC15, DNAJC19, NDUFA3, ND1, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFC2, NDUFS1, NDUFAF2, CYP2J2, CRELD1, ND5, NDUFA6, NDUFB1, NDUFA2, ND4, ND2, NDUFB8, NDUFV3, SAYSD1, NDUFA1, NDUFB2, NDUFS8, NDUFS2, NDUFV1, NDUFB3, NDUFV2, NDUFA10, NDUFAB1, NRP1, BSG, nsp6, nsp7, ORF3a, ORF7a,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
NDUFA7	chr19	8373533	A	C	single_nucleotide_variant	Benign	not_provided	SO:0001619\|non-coding_transcript_variant	SO:0001619\|non-coding_transcript_variant
NDUFA7	chr19	8386056	G	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
NDUFA7	chr19	8386059	T	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
NDUFA7	ESCA	chr19	8386227	8386227	G	A	Missense_Mutation	p.R6C	4
NDUFA7	PAAD	chr19	8381461	8381461	C	T	Missense_Mutation	p.R57H	3
NDUFA7	HNSC	chr19	8381382	8381382	C	G	Missense_Mutation	p.E83D	3
NDUFA7	BRCA	chr19	8381508	8381508	G	A	Silent	p.L41	2
NDUFA7	PAAD	chr19	8381461	8381461	C	T	Missense_Mutation		2
NDUFA7	ESCA	chr19	8386227	8386227	G	A	Missense_Mutation		2
NDUFA7	SARC	chr19	8385772	8385772	G	T	Missense_Mutation		2
NDUFA7	SARC	chr19	8386199	8386199	G	T	Missense_Mutation	p.A15E	2
NDUFA7	BLCA	chr19	8381530	8381530	C	A	Splice_Site		2
NDUFA7	STAD	chr19	8376455	8376455	C	T	Silent		2
NDUFA7	STAD	chr19	8376455	8376455	C	T	Silent	p.K92K	2
NDUFA7	BLCA	chr19	8386222	8386222	G	A	Silent	p.L7L	2
NDUFA7	LUAD	chr19	8381506	8381506	G	C	Missense_Mutation	p.P42R	1
NDUFA7	THCA	chr19	8381393	8381393	T	G	Missense_Mutation	p.K80Q	1
NDUFA7	BLCA	chr19	8381530	8381530	C	A	Splice_Site	p.R34_splice	1
NDUFA7	LUSC	chr19	8381519	8381519	G	T	Missense_Mutation	p.P38T	1
NDUFA7	COAD	chr19	8381449	8381449	C	T	Missense_Mutation	p.R61Q	1
NDUFA7	PRAD	chr19	8381425	8381425	A	G	Missense_Mutation	p.I69T	1
NDUFA7	SARC	chr19	8381451	8381451	G	T	Silent		1
NDUFA7	HNSC	chr19	8381382	8381382	C	G	Missense_Mutation		1
NDUFA7	LGG	chr19	8376449	8376449	C	T	Silent	p.A94A	1
NDUFA7	BLCA	chr19	8381483	8381483	A	G	Missense_Mutation		1
NDUFA7	LGG	chr19	8381422	8381424	ATG	-	In_Frame_Del	p.IM69del	1
NDUFA7	LIHC	chr19	8386229	8386229	G	A	Missense_Mutation	p.T5I	1
NDUFA7	TGCT	chr19	8376431	8376431	G	A	Silent		1
NDUFA7	BLCA	chr19	8381483	8381483	A	G	Missense_Mutation	p.S50P	1

Copy number variation (CNV) of NDUFA7
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across NDUFA7
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
103119	SARC	TCGA-DX-A1KY-01A	ABHD17A	chr19	1879920	-	NDUFA7	chr19	8381529	-
103119	ESCA	TCGA-IG-A3QL	ASNA1	chr19	12849472	+	NDUFA7	chr19	8381529	-
103119	N/A	EC453191	FAM193A	chr4	2552812	-	NDUFA7	chr19	8382174	+
93052	N/A	BG030910	NDUFA7	chr19	8376250	-	ANKRD44	chr2	197847918	+
58110	HNSC	TCGA-D6-6515	NDUFA7	chr19	8381379	-	PRKCG	chr19	54406326	+
58110	HNSC	TCGA-D6-6515-01A	NDUFA7	chr19	8381380	-	PRKCG	chr19	54406327	+
102598	N/A	CN412416	NDUFA7	chr19	8381403	-	PRKCSH	chr19	11556248	+
101173	N/A	BU552959	NDUFA7	chr19	8376260	-	RAD51B	chr14	68328290	+
99812	N/A	AV682147	NDUFA7	chr19	8376244	-	RIN2	chr20	19881585	+
58110	BRCA	TCGA-BH-A0BR-01A	NDUFA7	chr19	8381380	-	SH2D3A	chr19	6754943	-
58110	BRCA	TCGA-BH-A0BR-01A	NDUFA7	chr19	8381380	-	SH2D3A	chr19	6755326	-
103185	N/A	BG574678	NDUFA7	chr19	8376244	-	ZNRF3	chr22	29406294	-
103119	N/A	FN156480	THSD7B	chr2	137634523	+	NDUFA7	chr19	8376481	-
103119	BRCA	TCGA-BH-A0BT-01A	ZNF98	chr19	22715141	-	NDUFA7	chr19	8376479	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRP	NDUFA7	0.000406752659077248	0.011
BRCA	NDUFA7	0.0117593085799899	0.32
ACC	NDUFA7	0.0312680277448787	0.81
MESO	NDUFA7	0.0421156165158488	1

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	NDUFA7	0.000359977037584556	0.011
LGG	NDUFA7	1.14598364894072e-05	0.00038
BRCA	NDUFA7	0.000129031242943231	0.0041
PAAD	NDUFA7	0.0139271567722596	0.42

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
O95182	DB00157	NADH		Small molecule	Approved\|Nutraceutical
O95182	DB00157	NADH

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source