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Center for Computational Systems Medicine
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Gene Summary

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Translation studies in PubMed

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Exon Skipping Events

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Expression

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Expression Regulation

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Associated Genes

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Protein 3D Structure

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Protein-Protein Interaction

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Mutations

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Prognostic Analysis

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Gender Association

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Age Association

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Related Drugs

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Related Diseases

Translation Factor: MRPS18C (NCBI Gene ID:51023)


Gene Summary

check button Gene Summary
Gene InformationGene Name: MRPS18C
Gene ID: 51023
Gene Symbol

MRPS18C

Gene ID

51023

Gene Namemitochondrial ribosomal protein S18C
SynonymsCGI-134|MRP-S18-1|MRP-S18-c|MRPS18-1|S18mt-c|mrps18-c
Cytomap

4q21.23

Type of Geneprotein-coding
Description28S ribosomal protein S18c, mitochondrial28S ribosomal protein S18-1, mitochondrialmitochondrial ribosomal protein S18-1mitochondrial small ribosomal subunit protein bS18cmitochondrial small ribosomal subunit protein bS18mmitochondrial small ribosoma
Modification date20200313
UniProtAcc

Q9Y3D5


check button Child GO biological process term(s) under GO:0006412
GO IDGO term
GO:0005840Ribosome
GO:0006412Translation


check button Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Inferred gene age of translation factor.
GeneInferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
MRPS18C>1119.25


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Translation Studies in PubMed

check button We searched PubMed using 'MRPS18C[title] AND translation [title] AND human.'
GeneTitlePMID
MRPS18C..


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Exon Skipping Events

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.
all structure

check button Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ENSTExon skip start (DNA)Exon Skip end (DNA)ORF
ENST000002954918437949884379582In-frame
ENST000002954918438089284380950Frame-shift

check button Exon skipping position in the amino acid sequence.
ENSTExon skip start (DNA)Exon Skip end (DNA)Len(transcript seq)Exon skip start (mRNA)Exon Skip end (mRNA)Len(amino acid seq)Exon skip start (AA)Exon Skip end (AA)
ENST00000295491843794988437958216602643471425078

check button Potentially (partially) lost protein functional features of UniProt.
UniProtAccExon skip start (AA)Exon Skip end (AA)Function feature start (AA)Function feature end (AA)Functional feature typeFunctional feature desc.


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Expression


check buttonGene expression level across TCGA pancancer
all structure

check buttonGene expression level across GTEx pantissue
all structure

check buttonExpression level of gene isoforms across TCGA pancancer
all structure

check buttonExpression level of gene isoforms across GTEx pantissue
all structure

check buttonCancer(tissue) type-specific expression level of Translation factor using z-score distriution
all structure

check buttonDifferential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)
all structure
Cancer typeTranslation factorFCadj.pval
LIHCMRPS18C-1.253360420466980.00251545393492315
COADMRPS18C-3.485058302403650.00322914123535157


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Expression Regulation


check buttonTranslation factor expression regulation through miRNA binding
Cancer typeGenemiRNATargetScan binding score (Context++ score percentile)CoefficientPvalue


check buttonTranslation factor expression regulation through methylation in the promoter of Translation factor
Cancer typeGenemethyl group bmethyl group aDEG pvalavg methyl in bavg methyl in aavg exp in bavg exp in a

check buttonTranslation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)
Cancer typeGenemethyl group bmethyl group aDEG pvalavg methyl in bavg methyl in aavg exp in bavg exp in a

check buttonTranslation factor expression regulation through copy number variation of Translation factor
Cancer typeGeneCoefficientPvalue
LUSCMRPS18C-0.1166267320.003683591
CHOLMRPS18C-0.0710659620.009926326

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Associated Genes


check button Strongly correlated genes belong to cellular important gene groups with MRPS18C (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)
all structure
Cancer typeGene groupTranslation factorCorrelated geneCoefficientPvalue
DLBCCell metabolism geneMRPS18CPSMD130.8056417394.99E-12
DLBCCell metabolism geneMRPS18CTIMM500.8056745964.97E-12
DLBCCell metabolism geneMRPS18CPOLR2L0.8156550231.66E-12
DLBCCell metabolism geneMRPS18CSNRPD30.8219395548.03E-13
DLBCCell metabolism geneMRPS18CPSMC30.8356622481.48E-13
DLBCCell metabolism geneMRPS18CTIMM8B0.8409074227.47E-14
DLBCCell metabolism geneMRPS18CSAMM500.8469557563.28E-14
DLBCCell metabolism geneMRPS18CTIMM100.8728357116.20E-16
GBMEpifactorMRPS18CDPY300.8442345636.50E-48
THYMTFMRPS18CDNTTIP10.8163304822.20E-30
UCSTFMRPS18CDNTTIP10.8163304822.20E-30


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Protein structure


check button Protein 3D structure
Visit iCn3D.


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Protein-Protein Interaction


check button Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))
all structure

check buttonOverlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))
all structure
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* Edge colors based on TCGA cancer types.

check button* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))
all structure
Cancer typeTranslation factorInteracting protein coding geneFCadj.pval
BRCAMRPS18CMRPS15-2.195675516823180.000188684660674703
KICHMRPS18CMRPS51.251082878384370.000249803066253662
LUADMRPS18CMRPS18A-1.541238640420490.000452706327224566
LIHCMRPS18CMRPS71.270293954772080.00182077236082954
STADMRPS18CMRPS16-1.642080849874310.00239070039242506
KIRCMRPS18CMRPS151.115722838360120.00361818577801855
HNSCMRPS18CMRPS16-2.015646218218030.00518989327406416
KICHMRPS18CMRPS21.265439895550150.0114533305168152
THCAMRPS18CMRPS15-1.199606024229950.0140154883942907
PRADMRPS18CMRPS18A-1.892511955532890.0168224419088856
ESCAMRPS18CMRPS5-2.154401187478540.0185546875
ESCAMRPS18CMRPS2-3.205567880846750.0244140625
THCAMRPS18CMRPS11-3.106947285409620.0252226935182201
BLCAMRPS18CMRPS11-2.302769989682190.040130615234375
THCAMRPS18CMRPS101.334136917649911.55171507174296e-05
LUADMRPS18CMRPS5-2.208819458859271.77904381378076e-06
LUSCMRPS18CMRPS18A-4.261818030181251.79996309233889e-05
LUSCMRPS18CMRPS2-2.709308464885081.92864354932136e-09
BRCAMRPS18CMRPS11-1.243049779768042.31302509538916e-07
LUADMRPS18CMRPL42-6.346102496024912.48255276366547e-08
LUADMRPS18CMRPS14-3.026349140226474.24616078981701e-06
LIHCMRPS18CMRPS2-1.147710553588284.2584580238307e-05
LUSCMRPS18CMRPS5-7.659563899623194.27210217182982e-06
KIRCMRPS18CMRPL42-4.3820953362485.26630854166927e-06
LUSCMRPS18CMRPS11-2.90040975414445.43966600483641e-07
HNSCMRPS18CMRPS18A-2.45201201684755.97184352955084e-05
LUSCMRPS18CMRPS14-3.867261633642216.1453992201761e-05
BRCAMRPS18CMRPS7-2.127874602704349.33194208595055e-10


check button Protein-protein interactors with this translation factor (BIOGRID-3.4.160)
PPI interactors with MRPS18C
LIG4, SHMT2, MOV10, NOL12, TRA2A, RPL6, MRPS2, TRMT10B, HNRNPA1, ZNF707, MRPS31, MRPS5, MRPS11, MRPS6, PPTC7, MRPS34, AURKAIP1, PDGFB, MRPS27, SNRNP70, ZBTB48, GLTSCR2, CCDC59, RPL18, E4F1, HEXIM1, MEPCE, LARP7, HSPD1, TCF7L2, ALYREF, PRKCI, ESR1, IMMP2L, GRSF1, ACAD9, AUH, C12orf65, C1QBP, C21orf33, C6orf203, C8orf82, CCDC90B, CS, DHX30, FASTKD3, FASTKD5, GFM1, HINT2, ICT1, LRPPRC, CCDC109B, MDH2, METTL15, METTL17, MRPL11, MRPS12, MRPS26, MRRF, MTERF3, MTIF2, MTIF3, MTRF1, MTRF1L, NGRN, PMPCA, PMPCB, RPUSD4, SLIRP, SSBP1, TACO1, TBRG4, TFAM, TMEM70, TRUB2, TSFM, TUFM, VWA8, EXD2, FASN, MRPS15, MRPS9, N4BP2L2, YBX1, RPL13A, H1FNT, EDC4, MRPS17, MRPS22, LIN28B, ZNF777, SULF2, H2AFB3, ABT1, SRSF5, DSG4, ZNF17, MRPL2, RPS24, MRPS35, GNL2, PCBP4, ZNF460, PTCD3, MRPS10, ZKSCAN8, MRPS33, RPL27A, MRPS28, LANCL2, RPL17, DBT, SRSF6, SUPV3L1, ZNF467, RPS9, MRPS21, MRPS14, MRPS23, SIRT3, MCAT, FAM120A, HNRNPU, DAP3, MRPS7, SMG5, MRPS25, RPL37, UTP23, MRPS24, DUSP14, SRSF3, PYCRL, RBMS2, MRPS16, NUDT6, NOA1, MRPS18B, RPL26, PRR3, SH2D4A, RPL13, UQCC1, PRIM2, SRP14, UQCC2, FGF17, SRSF7, NEIL1, MANF, PLCB3, RPL19, ERAL1, RPL23A, HIST1H2AM, PAK3, RPL35, ARFGAP2, CHMP1A, SRP54, PPP1R12A, TOMM34, TTC9C, DNM3, ZC3H3, SRSF1, ARHGEF1, ZNF574, CCDC43, CHMP2A, DNM2, RPL3, GNA13, SURF6, CCDC12, SH3PXD2B, ZC3HAV1, LIN28A, RPL10, ZMAT2, BTF3L4, RPS27, KLF12,


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Mutations


check button Clinically associated variants from ClinVar.
GeneChrPositionRefSeqVarSeqRefSeeqVarTypePathogenicDiseaseVarInfo


check button nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.
all structure


check button SNVs and Indels
GeneCancer typeChromosomeStartEndRefSeeqMutSeqMutation typeAAchange# samples
MRPS18CUCECchr48438234384382343GAMissense_Mutationp.R141Q3
MRPS18CBRCAchr48437726984377271GAA-In_Frame_Delp.K15in_frame_del2
MRPS18CSKCMchr48437727284377272GASilentp.K14K2
MRPS18CCESCchr48438091284380912CGMissense_Mutation2
MRPS18CSKCMchr48437727784377277TCMissense_Mutationp.L16S2
MRPS18CCESCchr48437726184377261CTSilent2
MRPS18CSTADchr48437954184379541TCMissense_Mutationp.C65R2
MRPS18CBLCAchr48438216584382165TAMissense_Mutationp.I111N2
MRPS18CLUADchr48437729484377294GAMissense_Mutationp.A22T2
MRPS18CBRCAchr48437723684377236CTMissense_Mutationp.R1C2
MRPS18CSARCchr48438089284380892GTSplice_Site1
MRPS18CBLCAchr48438216584382165TAMissense_Mutation1
MRPS18CBLCAchr48437720384377203CTMissense_Mutation1
MRPS18CSKCMchr48437950084379500CTSplice_Sitep.P51_splice1
MRPS18CBLCAchr48437725584377255GAMissense_Mutation1
MRPS18CKIRCchr48437958084379580CAMissense_Mutationp.Q78K1
MRPS18CBLCAchr48437725684377256GTMissense_Mutation1
MRPS18CLGGchr48437955584379555ACSilentp.G69G1
MRPS18CTHCAchr48437723684377236CTSilent1
MRPS18CBLCAchr48437956584379565GAMissense_Mutation1
MRPS18CLGGchr48437955584379555ACSilent1
MRPS18CTHCAchr48437723684377236CTSilentp.A2A1
MRPS18CLIHCchr48437952884379528AGSilent1
MRPS18CBLCAchr48437725584377255GAMissense_Mutationp.G9S1
MRPS18CLIHCchr48438232184382321AGMissense_Mutationp.K134E1
MRPS18CUVMchr48437725484377254CTSilentp.C8C1
MRPS18CBLCAchr48437725684377256GTMissense_Mutationp.G9V1
MRPS18CBLCAchr48437956584379565GAMissense_Mutationp.D73N1
MRPS18CLUADchr48437723984377239TCSilentp.A3A1

check buttonCopy number variation (CNV) of MRPS18C
* Click on the image to open the original image in a new window.
all structure

check buttonFusion gene breakpoints (product of the structural variants (SVs)) across MRPS18C
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


check button Fusion genes with this translation factor from FusionGDB2.0.
FusionGDB2 IDDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
37988ESCATCGA-LN-A9FOFAM175Achr484384646-MRPS18Cchr484380892+
37988N/AAI696129FAM175Achr484382126-MRPS18Cchr484382185-
37998N/AEC499381HSPD1chr2198351399+MRPS18Cchr484378825+
80403GBMTCGA-28-5209-01AMRPS18Cchr484378111+DLG1chr3196796131-
96150OVTCGA-13-1511MRPS18Cchr484378111+ENOPH1chr483369072+
96150OVTCGA-13-1511MRPS18Cchr484379582+ENOPH1chr483369072+
96150OVTCGA-13-1511-01AMRPS18Cchr484378111+ENOPH1chr483369073+
96150OVTCGA-13-1511-01AMRPS18Cchr484379582+ENOPH1chr483369073+
55151N/ABX328907MRPS18Cchr484382386+SIGLEC10chr1951913817-


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Prognostic Analysis


check button Kaplan-Meier plots with logrank tests of overall survival (OS)
all structure
Cancer typeTranslation factorCoefficentHazard ratioWald test pvalLikelihool ratio pvalLogrank test pval# samples


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Translation factor and Gender


check button Differential gene expression between female and male. (Wilcoxon test, pval<0.05)
all structure
Cancer typeTranslation factorpvaladj.p

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Translation factor and Age


check button Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)
all structure
Cancer typeTranslation factorpvaladj.p
LIHCMRPS18C0.0004817118655446570.016
KIRPMRPS18C0.005092541592400660.16
LAMLMRPS18C0.04393791902694811
BRCAMRPS18C0.03836246871420511
SKCMMRPS18C0.04358931225804651
THYMMRPS18C0.01911913761740540.59

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Related Drugs


check button Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)
UniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases


check button Diseases associated with this translation factor.
(DisGeNet 4.0)
Disease IDDisease Name# PubMedsDisease source