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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPS27L (NCBI Gene ID:51065)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPS27L
	Gene ID: 51065
	Gene Symbol	RPS27L
	Gene ID	51065
	Gene Name	ribosomal protein S27 like
	Synonyms	-
	Cytomap	15q22.2
	Type of Gene	protein-coding
	Description	40S ribosomal protein S27-likesmall ribosomal subunit protein eS27-like
	Modification date	20200313
	UniProtAcc	Q71UM5

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0005840	Ribosome
GO:0045727	Positive regulation of translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RPS27L	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	17057733
Hgene	RPS27L	GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	18056458
Hgene	RPS27L	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	17057733\|18056458
Hgene	RPS27L	GO:0045727	positive regulation of translation	18056458

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
RPS27L	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'RPS27L[title] AND translation [title] AND human.'

Gene	Title	PMID
RPS27L	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000330964	63448611	63448720	Frame-shift

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
COAD	RPS27L	-2.40064187129656	0.00293293595314026
BLCA	RPS27L	2.7195990465697	0.0289306640625
KIRC	RPS27L	1.54592290890765	2.72286325678163e-08
THCA	RPS27L	2.60712210121345	4.8678604404995e-10

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type

Gene

Coefficient

Pvalue

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPS27L (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type

Gene group

Translation factor

Correlated gene

Coefficient

Pvalue

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
BRCA	RPS27L	RPS24	-2.39554944754566	0.000117697958041698
STAD	RPS27L	RPS23	1.85076760664576	0.000364991836249828
COAD	RPS27L	RPS3	1.48730375143014	0.000411599874496461
COAD	RPS27L	RPS20	-3.55214827660447	0.0010443925857544
LUAD	RPS27L	RPS8	-2.73463137299833	0.00134906742748461
PRAD	RPS27L	RPS24	1.80095071289163	0.00246137516089789
CHOL	RPS27L	RPS3A	-2.95593562926717	0.00390625
PRAD	RPS27L	RPS8	1.32957024497066	0.00418162555035067
KICH	RPS27L	RPS20	-2.30757233561727	0.00612920522689819
LUSC	RPS27L	RPS8	-1.95298795124964	0.00724217523600344
THCA	RPS27L	FAU	1.18509450470262	0.0152379297688856
LUAD	RPS27L	RPS4X	-2.43594282676366	0.0163893452361939
LUSC	RPS27L	RPS23	1.46751169891047	0.0174932185880974
BLCA	RPS27L	RPS24	-1.7374699818168	0.0258216857910156
HNSC	RPS27L	RPS3	-4.73505819095135	0.0273726439852453
KIRP	RPS27L	FAU	-1.04355048353271	0.0309218638576567
UCEC	RPS27L	RPS3A	-1.59353225186968	0.03125
BLCA	RPS27L	RPS20	-3.2869410015055	0.0360679626464844
UCEC	RPS27L	RPS23	-2.03658159814007	0.046875
HNSC	RPS27L	RPS25	2.24439018636525	1.07420805761649e-06
KIRC	RPS27L	RPS8	-3.97243608476641	1.19932271980764e-10
KIRC	RPS27L	FAU	-2.50135425883801	1.33253564327251e-08
KIRP	RPS27L	RPS20	-1.44580921357944	1.60322524607182e-05
KIRC	RPS27L	RPS4X	-1.64140073680063	1.72010286166321e-07
THCA	RPS27L	RPS2	-2.9749691422722	1.8399565126656e-05
BRCA	RPS27L	RPS3A	-2.82352324218764	1.9558540533629e-14
KIRC	RPS27L	RPS2	-3.31623058345719	2.17100738110179e-12
KIRC	RPS27L	RPS24	-2.03004684849548	3.10358016139282e-10
BRCA	RPS27L	RPS4X	-1.55343710903986	3.36588066248297e-09
KIRP	RPS27L	RPS2	-2.72788021566791	5.12227416038514e-08
LUAD	RPS27L	RPS2	-2.88992098496468	6.51132046672323e-08
THCA	RPS27L	RPS4X	1.49777877118816	6.68348444344278e-07
KIRP	RPS27L	RPS8	-1.20432400687215	7.40401446819306e-05
KIRC	RPS27L	RPS20	-2.62380824779569	7.86590430905899e-10
KICH	RPS27L	RPS2	-4.73426315307469	8.34465026855468e-07
STAD	RPS27L	RPS3A	1.42181649915045	9.0546440333128e-05
KIRC	RPS27L	RPS3	-1.29560847926387	9.05905681935088e-10

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPS27L

MDM2, EBNA-LP, VHL, RPL18, RPL21, RPL24, RPL37A, RPL10A, RPL15, RPL11, RPL12, RPS3, RPL27A, RPL7, RPL7A, RPL4, RPL23, RPS13, RPS20, RPL6, RPS2, RPL14, RPS16, RPS21, RPS6, RPS8, RPL19, RPLP0P6, RPL17, RPL23A, RPL22, RPL5, RPS25, RPL13, SNRPD3, ILF3, RPS28, RPS4X, RPL9, RPS11, RPS23, RPSA, RPS3A, RPL31, GNB2L1, RPS12, RPS24, RPLP2, MYC, RL1, G3BP1, IARS, PA2G4, RANBP9, RPS15A, EIF2S1, FAU, RPS7, RPS27, SYNCRIP, WIBG, ASB4, UNK, RPL35A, NPM1, ZMYND8, Ktn1, Rrbp1, MCM2, ERBB3, ESRRB, CDC37, ZNF746, CTDSP2, LNX1, RIPK4, MAPK6, CHD3, RNF31, TNF, SPDL1, ESR2, HEXIM1, MEPCE, LARP7, AGR2, RECQL4, KDM6B, REST, TUBA1A, MAD2L2, VCP, KIAA1429, RC3H2, PHB, NR2C2, GBF1, AGRN, MAP3K14, SCARB2, SNRNP70, ARAF, WWP2, PLEKHA4, ZC3H18, RAB5A, E, M, nsp13, nsp4, nsp5, nsp6, ORF3a, ORF7a, ORF7b, S, ESR1, CIT, ANLN, CHMP4C, ECT2, KIF14, KIF20A, KIF23, PRC1, FGD2, LONP1, MKI67, INS, E5a, E5b, E7, RBM39, RIN3, EIF4E, EIF4EBP2, EIF4ENIF1, EIF4EBP1, HIF1AN, SMYD2, EIF4G3, DCLRE1B, REPIN1, SMYD3, ATP2A1, EBAG9, HIST1H2BG, SPRTN, CLIP4, ZRSR2, HFM1, Htatsf1, nsp1, ORF10, RB1CC1,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPS27L	BRCA	chr15	63448632	63448633	-	TAC	In_Frame_Ins	p.F32in_frame_insCI	3
RPS27L	HNSC	chr15	63447855	63447855	C	T	Missense_Mutation	p.C64Y	3
RPS27L	BRCA	chr15	63447802	63447802	G	A	Missense_Mutation	p.L82F	2
RPS27L	UCEC	chr15	63447807	63447807	C	T	Missense_Mutation	p.G80D	2
RPS27L	GBM	chr15	63433763	63433763	A	G	Missense_Mutation		1
RPS27L	SARC	chr15	63446239	63446239	G	T	Missense_Mutation		1
RPS27L	GBM	chr15	63419231	63419231	G	T	Nonsense_Mutation		1
RPS27L	SARC	chr15	63419128	63419128	C	T	Silent		1
RPS27L	UCEC	chr15	63448669	63448670	TA	-	Frame_Shift_Del	p.H19fs	1
RPS27L	COAD	chr15	63448679	63448679	C	A	Missense_Mutation	p.K16N	1
RPS27L	KIRC	chr15	63447803	63447805	AAT	-	In_Frame_Del	p.I81del	1
RPS27L	ESCA	chr15	63447758	63447759	-	AT	Frame_Shift_Ins	p.H97fs	1
RPS27L	LIHC	chr15	63447807	63447807	C	T	Missense_Mutation		1
RPS27L	ESCA	chr15	63447760	63447760	G	T	Missense_Mutation	p.L96I	1
RPS27L	LIHC	chr15	63447797	63447797	T	C	Silent		1
RPS27L	ESCA	chr15	63448736	63448736	T	C	Missense_Mutation	p.I13M	1
RPS27L	LIHC	chr15	63447880	63447880	A	-	Frame_Shift_Del	p.C56fs	1
RPS27L	ESCA	chr15	63447758	63447759	-	-	Frame_Shift_Ins		1
RPS27L	LIHC	chr15	63448665	63448665	T	-	Frame_Shift_Del	p.K22fs	1
RPS27L	ESCA	chr15	63447760	63447760	G	T	Missense_Mutation		1
RPS27L	LUAD	chr15	63447831	63447831	C	T	Missense_Mutation	p.R72K	1
RPS27L	ESCA	chr15	63448736	63448736	T	C	Missense_Mutation		1
RPS27L	PCPG	chr15	63447932	63447932	T	C	Splice_Site		1
RPS27L	ACC	chr15	63447815	63447817	TAT	-	In_Frame_Del	p.I77del	1
RPS27L	ESCA	chr15	63447758	63447759	-	AT	Frame_Shift_Ins	p.P96fs	1
RPS27L	READ	chr15	63446232	63446232	T	C	Silent	p.X85X	1
RPS27L	BLCA	chr15	63449670	63449670	G	A	Missense_Mutation		1

Copy number variation (CNV) of RPS27L
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RPS27L
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
91194	N/A	BG231299	CCBE1	chr18	57297499	-	RPS27L	chr15	63446052	+
101933	N/A	BF978658	RPS27L	chr15	63448638	-	CSDE1	chr1	115260758	-
89109	N/A	BM016297	RPS27L	chr15	63446052	-	CUL5	chr11	107948357	+
102163	N/A	BQ027670	RPS27L	chr15	63447489	-	DNAJC1	chr10	22045466	+
83393	N/A	AI493202	RPS27L	chr15	63449641	+	ERMP1	chr9	5774202	-
77765	N/A	BF185744	RPS27L	chr15	63448641	-	KCNN2	chr5	113582897	+
90870	N/A	CS119643	RPS27L	chr15	63446052	-	PLCB1	chr20	8515842	+
94404	LUSC	TCGA-66-2767	RPS27L	chr15	63448611	-	SPPL2A	chr15	51028399	-
101419	N/A	BF245196	RPS27L	chr15	63446052	-	SULF2	chr20	46371706	-
77765	N/A	BF245442	RPS27L	chr15	63446052	-	TNFRSF10B	chr8	22898590	-
102874	N/A	AW474016	RPS27L	chr15	63449683	+	UBR2	chr6	42604150	+
101000	N/A	BF244104	RPS27L	chr15	63446052	-	WWP2	chr16	69931809	+
91197	UCEC	TCGA-B5-A0JN-01A	TLN2	chr15	62682884	+	RPS27L	chr15	63448720	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
TGCT	RPS27L	0.00764490514971697	0.21
SARC	RPS27L	0.0153450701736986	0.41

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUAD	RPS27L	0.018263563991937	0.53
KIRP	RPS27L	0.0171156421844474	0.51
LGG	RPS27L	2.98489307873507e-05	0.00099
LAML	RPS27L	0.0393768550881102	1
BRCA	RPS27L	0.00242986952967029	0.075
ESCA	RPS27L	9.06026225774691e-05	0.0029
READ	RPS27L	0.0270488392983154	0.76

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source