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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: MRPS2 (NCBI Gene ID:51116)

Gene Summary

Gene Summary

Gene Information	Gene Name: MRPS2
	Gene ID: 51116
	Gene Symbol	MRPS2
	Gene ID	51116
	Gene Name	mitochondrial ribosomal protein S2
	Synonyms	CGI-91\|COXPD36\|MRP-S2\|S2mt
	Cytomap	9q34.3
	Type of Gene	protein-coding
	Description	28S ribosomal protein S2, mitochondrialmitochondrial small ribosomal subunit protein uS2m
	Modification date	20200313
	UniProtAcc	Q9Y399

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0032543	Mitochondrial translation
GO:0005840	Ribosome
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
MRPS2	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'MRPS2[title] AND translation [title] AND human.'

Gene	Title	PMID
MRPS2	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000241600	138392843	138392969	In-frame
ENST00000371785	138392843	138392969	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000241600	138392843	138392969	1519	118	243	296	14	56
ENST00000371785	138392843	138392969	1657	253	378	296	14	56

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
Q9Y399	14	56	1	296	Chain	ID=PRO_0000134343;Note=28S ribosomal protein S2%2C mitochondrial
Q9Y399	14	56	1	296	Chain	ID=PRO_0000134343;Note=28S ribosomal protein S2%2C mitochondrial

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
KICH	MRPS2	1.26543989555015	0.0114533305168152
ESCA	MRPS2	-3.20556788084675	0.0244140625
LUSC	MRPS2	-2.70930846488508	1.92864354932136e-09
LIHC	MRPS2	-1.14771055358828	4.2584580238307e-05

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
CESC	MRPS2	-0.054708615	0.004751073
LGG	MRPS2	-0.076892898	0.033845304

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with MRPS2 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
BRCA	Cell metabolism gene	MRPS2	PMPCA	0.812940471	8.13E-288
CESC	Cell metabolism gene	MRPS2	PMPCA	0.823041369	3.71E-77
CHOL	Cell metabolism gene	MRPS2	UCK1	0.810851605	1.46E-11
CHOL	Cell metabolism gene	MRPS2	PSMB7	0.829430557	1.93E-12
DLBC	Cell metabolism gene	MRPS2	FPGS	0.802471087	6.97E-12
DLBC	Cell metabolism gene	MRPS2	PSMB7	0.804734012	5.49E-12
DLBC	Cell metabolism gene	MRPS2	DOHH	0.811635423	2.60E-12
DLBC	Cell metabolism gene	MRPS2	EXOSC4	0.819963323	1.01E-12
DLBC	Cell metabolism gene	MRPS2	NME1	0.82180234	8.16E-13
DLBC	Cell metabolism gene	MRPS2	POLR2H	0.827109944	4.32E-13
DLBC	Cell metabolism gene	MRPS2	ATP5G1	0.82894091	3.46E-13
DLBC	Cell metabolism gene	MRPS2	SNRPD2	0.835592516	1.50E-13
DLBC	Cell metabolism gene	MRPS2	MIF	0.838278895	1.06E-13
DLBC	Cell metabolism gene	MRPS2	TIMM50	0.838418387	1.04E-13
DLBC	Cell metabolism gene	MRPS2	SNRPE	0.839667869	8.81E-14
DLBC	Cell metabolism gene	MRPS2	TOMM22	0.841308573	7.08E-14
DLBC	Cell metabolism gene	MRPS2	SNRPD3	0.843529191	5.25E-14
DLBC	Cell metabolism gene	MRPS2	NME2	0.854203927	1.17E-14
DLBC	Cell metabolism gene	MRPS2	TIMM13	0.875619058	3.84E-16
DLBC	Cell metabolism gene	MRPS2	PMPCA	0.913814609	1.27E-19
DLBC	Epifactor	MRPS2	PELP1	0.815482743	1.69E-12
DLBC	Epifactor	MRPS2	FBL	0.818111719	1.25E-12
DLBC	Epifactor	MRPS2	EXOSC4	0.819963323	1.01E-12
DLBC	Epifactor	MRPS2	RUVBL2	0.836683552	1.30E-13
DLBC	TF	MRPS2	THAP4	0.806211438	4.69E-12
DLBC	TF	MRPS2	NME2	0.854203927	1.17E-14
DLBC	TSG	MRPS2	GADD45GIP1	0.816416454	1.52E-12
DLBC	TSG	MRPS2	NME1	0.82180234	8.16E-13
DLBC	TSG	MRPS2	PHB	0.857456879	7.21E-15
HNSC	Cell metabolism gene	MRPS2	PMPCA	0.808221675	8.18E-132
KICH	Cell metabolism gene	MRPS2	PMPCA	0.839283888	2.80E-25
KIRP	Cell metabolism gene	MRPS2	PMPCA	0.803105993	3.62E-74
LAML	Cell metabolism gene	MRPS2	SRM	0.812390296	6.57E-42
LAML	Cell metabolism gene	MRPS2	MIF	0.818990614	4.16E-43
LAML	Cell metabolism gene	MRPS2	ALG3	0.819289601	3.66E-43
LAML	Cell metabolism gene	MRPS2	RNPS1	0.85096419	1.08E-49
LAML	Epifactor	MRPS2	TRIM28	0.817259857	8.67E-43
LAML	Epifactor	MRPS2	RUVBL2	0.831195115	1.86E-45
LAML	Epifactor	MRPS2	PRMT1	0.833512234	6.34E-46
LAML	IUPHAR	MRPS2	TRIM28	0.817259857	8.67E-43
LAML	IUPHAR	MRPS2	PRMT1	0.833512234	6.34E-46
LAML	Kinase	MRPS2	TRIM28	0.817259857	8.67E-43
LAML	TF	MRPS2	THAP4	0.818311635	5.56E-43
LAML	TSG	MRPS2	GADD45GIP1	0.832709294	9.22E-46
MESO	Cell metabolism gene	MRPS2	PSMB7	0.805694792	4.96E-21
MESO	Cell metabolism gene	MRPS2	PMPCA	0.816470784	5.57E-22
PRAD	Cell metabolism gene	MRPS2	PTGES2	0.805870055	7.85E-127
PRAD	Cell metabolism gene	MRPS2	TIMM13	0.812742421	1.13E-130
PRAD	Cell metabolism gene	MRPS2	PMPCA	0.819550851	1.23E-134
PRAD	IUPHAR	MRPS2	PTGES2	0.805870055	7.85E-127
READ	Cell metabolism gene	MRPS2	EXOSC2	0.800531988	1.22E-24
READ	Cell metabolism gene	MRPS2	PTGES2	0.842429577	2.02E-29
READ	Cell metabolism gene	MRPS2	PMPCA	0.864332178	1.63E-32
READ	Epifactor	MRPS2	EXOSC2	0.800531988	1.22E-24
READ	IUPHAR	MRPS2	PTGES2	0.842429577	2.02E-29
SKCM	Cell metabolism gene	MRPS2	PMPCA	0.80277026	4.73E-108
TGCT	Cell metabolism gene	MRPS2	PSMB7	0.852842016	2.62E-45
TGCT	TF	MRPS2	REXO4	0.807446575	4.01E-37
THYM	Cell metabolism gene	MRPS2	PIGU	0.800468223	1.91E-28
THYM	Cell metabolism gene	MRPS2	SLC27A5	0.80113983	1.59E-28
THYM	Cell metabolism gene	MRPS2	GEMIN6	0.803338729	8.76E-29
THYM	Cell metabolism gene	MRPS2	BCAT2	0.805248788	5.18E-29
THYM	Cell metabolism gene	MRPS2	PSMC1	0.80832754	2.20E-29
THYM	Cell metabolism gene	MRPS2	MIF	0.810934867	1.05E-29
THYM	Cell metabolism gene	MRPS2	POLE4	0.811271018	9.54E-30
THYM	Cell metabolism gene	MRPS2	CYC1	0.811443655	9.08E-30
THYM	Cell metabolism gene	MRPS2	ECHS1	0.813830578	4.56E-30
THYM	Cell metabolism gene	MRPS2	ITPA	0.81465188	3.59E-30
THYM	Cell metabolism gene	MRPS2	PHPT1	0.814762602	3.48E-30
THYM	Cell metabolism gene	MRPS2	APRT	0.817058446	1.77E-30
THYM	Cell metabolism gene	MRPS2	NME1	0.817390571	1.61E-30
THYM	Cell metabolism gene	MRPS2	ACOT8	0.818505557	1.15E-30
THYM	Cell metabolism gene	MRPS2	HMBS	0.826238245	1.08E-31
THYM	Cell metabolism gene	MRPS2	GSTP1	0.827041131	8.39E-32
THYM	Cell metabolism gene	MRPS2	TIMM8B	0.828152687	5.90E-32
THYM	Cell metabolism gene	MRPS2	LCMT1	0.828789569	4.82E-32
THYM	Cell metabolism gene	MRPS2	SNRPD2	0.831607885	1.95E-32
THYM	Cell metabolism gene	MRPS2	MMAB	0.831921878	1.76E-32
THYM	Cell metabolism gene	MRPS2	GFER	0.833753138	9.65E-33
THYM	Cell metabolism gene	MRPS2	TIMM10	0.834235118	8.23E-33
THYM	Cell metabolism gene	MRPS2	PGLS	0.835302507	5.78E-33
THYM	Cell metabolism gene	MRPS2	NANS	0.837453446	2.81E-33
THYM	Cell metabolism gene	MRPS2	GMPPA	0.84105625	8.20E-34
THYM	Cell metabolism gene	MRPS2	COASY	0.841113392	8.04E-34
THYM	Cell metabolism gene	MRPS2	PSMB3	0.843086007	4.04E-34
THYM	Cell metabolism gene	MRPS2	ALG3	0.846686253	1.12E-34
THYM	Cell metabolism gene	MRPS2	POLR2H	0.847295587	9.02E-35
THYM	Cell metabolism gene	MRPS2	EXOSC5	0.847595541	8.09E-35
THYM	Cell metabolism gene	MRPS2	TOMM40	0.84771568	7.75E-35
THYM	Cell metabolism gene	MRPS2	PSMB7	0.851506445	1.92E-35
THYM	Cell metabolism gene	MRPS2	PPCDC	0.855038508	5.06E-36
THYM	Cell metabolism gene	MRPS2	PYCRL	0.860218443	6.71E-37
THYM	Cell metabolism gene	MRPS2	NME2	0.86041666	6.20E-37
THYM	Cell metabolism gene	MRPS2	PSMD4	0.860879471	5.15E-37
THYM	Cell metabolism gene	MRPS2	GEMIN7	0.862859926	2.32E-37
THYM	Cell metabolism gene	MRPS2	ATP5G1	0.872138148	4.62E-39
THYM	Cell metabolism gene	MRPS2	DOHH	0.873091098	3.04E-39
THYM	Cell metabolism gene	MRPS2	POLR2I	0.877228886	4.72E-40
THYM	Cell metabolism gene	MRPS2	TIMM50	0.877895595	3.48E-40
THYM	Cell metabolism gene	MRPS2	HMOX2	0.880437708	1.06E-40
THYM	Cell metabolism gene	MRPS2	TIMM13	0.881250016	7.25E-41
THYM	Cell metabolism gene	MRPS2	PSMC5	0.881818253	5.53E-41
THYM	Cell metabolism gene	MRPS2	DPM2	0.884851951	1.28E-41
THYM	Cell metabolism gene	MRPS2	MTX1	0.887562486	3.32E-42
THYM	Cell metabolism gene	MRPS2	PMPCA	0.899795236	4.81E-45
THYM	Cell metabolism gene	MRPS2	PTGES2	0.903457407	5.76E-46
THYM	Cell metabolism gene	MRPS2	EXOSC4	0.905911678	1.32E-46
THYM	CGC	MRPS2	NTHL1	0.81642511	2.14E-30
THYM	CGC	MRPS2	PRCC	0.845747975	1.57E-34
THYM	CGC	MRPS2	ASPSCR1	0.90009604	4.05E-45
THYM	Epifactor	MRPS2	ZNHIT1	0.800213749	2.04E-28
THYM	Epifactor	MRPS2	LAS1L	0.814502843	3.75E-30
THYM	Epifactor	MRPS2	NOC2L	0.822421378	3.52E-31
THYM	Epifactor	MRPS2	BRMS1	0.829491036	3.85E-32
THYM	Epifactor	MRPS2	EXOSC5	0.847595541	8.09E-35
THYM	Epifactor	MRPS2	SIRT6	0.849618507	3.87E-35
THYM	Epifactor	MRPS2	PRMT1	0.850163478	3.16E-35
THYM	Epifactor	MRPS2	PRPF31	0.856361387	3.04E-36
THYM	Epifactor	MRPS2	FBL	0.857252322	2.16E-36
THYM	Epifactor	MRPS2	EXOSC4	0.905911678	1.32E-46
THYM	IUPHAR	MRPS2	SLC27A5	0.80113983	1.59E-28
THYM	IUPHAR	MRPS2	BCAT2	0.805248788	5.18E-29
THYM	IUPHAR	MRPS2	SLC25A39	0.814021641	4.32E-30
THYM	IUPHAR	MRPS2	SIRT6	0.849618507	3.87E-35
THYM	IUPHAR	MRPS2	PRMT1	0.850163478	3.16E-35
THYM	IUPHAR	MRPS2	ATP6V0B	0.857876692	1.69E-36
THYM	IUPHAR	MRPS2	HMOX2	0.880437708	1.06E-40
THYM	IUPHAR	MRPS2	PTGES2	0.903457407	5.76E-46
THYM	TF	MRPS2	ZBTB48	0.800471341	1.90E-28
THYM	TF	MRPS2	ZNF524	0.800584747	1.85E-28
THYM	TF	MRPS2	CENPB	0.834959333	6.48E-33
THYM	TF	MRPS2	NME2	0.86041666	6.20E-37
THYM	TF	MRPS2	ZNF787	0.87802508	3.27E-40
THYM	TF	MRPS2	REXO4	0.891478646	4.46E-43
THYM	TF	MRPS2	ZNF581	0.918986729	2.48E-50
THYM	TSG	MRPS2	ZBTB48	0.800471341	1.90E-28
THYM	TSG	MRPS2	NME1	0.817390571	1.61E-30
THYM	TSG	MRPS2	GSTP1	0.827041131	8.39E-32
THYM	TSG	MRPS2	BRMS1	0.829491036	3.85E-32
THYM	TSG	MRPS2	SIRT6	0.849618507	3.87E-35
THYM	TSG	MRPS2	TSSC4	0.868326351	2.39E-38
THYM	TSG	MRPS2	GADD45GIP1	0.87278402	3.48E-39
THYM	TSG	MRPS2	STUB1	0.88550152	9.27E-42
THYM	TSG	MRPS2	PHB	0.902066594	1.30E-45
UCEC	Cell metabolism gene	MRPS2	PMPCA	0.806103602	3.19E-47
UCS	Cell metabolism gene	MRPS2	PIGU	0.800468223	1.91E-28
UCS	Cell metabolism gene	MRPS2	SLC27A5	0.80113983	1.59E-28
UCS	Cell metabolism gene	MRPS2	GEMIN6	0.803338729	8.76E-29
UCS	Cell metabolism gene	MRPS2	BCAT2	0.805248788	5.18E-29
UCS	Cell metabolism gene	MRPS2	PSMC1	0.80832754	2.20E-29
UCS	Cell metabolism gene	MRPS2	MIF	0.810934867	1.05E-29
UCS	Cell metabolism gene	MRPS2	POLE4	0.811271018	9.54E-30
UCS	Cell metabolism gene	MRPS2	CYC1	0.811443655	9.08E-30
UCS	Cell metabolism gene	MRPS2	ECHS1	0.813830578	4.56E-30
UCS	Cell metabolism gene	MRPS2	ITPA	0.81465188	3.59E-30
UCS	Cell metabolism gene	MRPS2	PHPT1	0.814762602	3.48E-30
UCS	Cell metabolism gene	MRPS2	APRT	0.817058446	1.77E-30
UCS	Cell metabolism gene	MRPS2	NME1	0.817390571	1.61E-30
UCS	Cell metabolism gene	MRPS2	ACOT8	0.818505557	1.15E-30
UCS	Cell metabolism gene	MRPS2	HMBS	0.826238245	1.08E-31
UCS	Cell metabolism gene	MRPS2	GSTP1	0.827041131	8.39E-32
UCS	Cell metabolism gene	MRPS2	TIMM8B	0.828152687	5.90E-32
UCS	Cell metabolism gene	MRPS2	LCMT1	0.828789569	4.82E-32
UCS	Cell metabolism gene	MRPS2	SNRPD2	0.831607885	1.95E-32
UCS	Cell metabolism gene	MRPS2	MMAB	0.831921878	1.76E-32
UCS	Cell metabolism gene	MRPS2	GFER	0.833753138	9.65E-33
UCS	Cell metabolism gene	MRPS2	TIMM10	0.834235118	8.23E-33
UCS	Cell metabolism gene	MRPS2	PGLS	0.835302507	5.78E-33
UCS	Cell metabolism gene	MRPS2	NANS	0.837453446	2.81E-33
UCS	Cell metabolism gene	MRPS2	GMPPA	0.84105625	8.20E-34
UCS	Cell metabolism gene	MRPS2	COASY	0.841113392	8.04E-34
UCS	Cell metabolism gene	MRPS2	PSMB3	0.843086007	4.04E-34
UCS	Cell metabolism gene	MRPS2	ALG3	0.846686253	1.12E-34
UCS	Cell metabolism gene	MRPS2	POLR2H	0.847295587	9.02E-35
UCS	Cell metabolism gene	MRPS2	EXOSC5	0.847595541	8.09E-35
UCS	Cell metabolism gene	MRPS2	TOMM40	0.84771568	7.75E-35
UCS	Cell metabolism gene	MRPS2	PSMB7	0.851506445	1.92E-35
UCS	Cell metabolism gene	MRPS2	PPCDC	0.855038508	5.06E-36
UCS	Cell metabolism gene	MRPS2	PYCRL	0.860218443	6.71E-37
UCS	Cell metabolism gene	MRPS2	NME2	0.86041666	6.20E-37
UCS	Cell metabolism gene	MRPS2	PSMD4	0.860879471	5.15E-37
UCS	Cell metabolism gene	MRPS2	GEMIN7	0.862859926	2.32E-37
UCS	Cell metabolism gene	MRPS2	ATP5G1	0.872138148	4.62E-39
UCS	Cell metabolism gene	MRPS2	DOHH	0.873091098	3.04E-39
UCS	Cell metabolism gene	MRPS2	POLR2I	0.877228886	4.72E-40
UCS	Cell metabolism gene	MRPS2	TIMM50	0.877895595	3.48E-40
UCS	Cell metabolism gene	MRPS2	HMOX2	0.880437708	1.06E-40
UCS	Cell metabolism gene	MRPS2	TIMM13	0.881250016	7.25E-41
UCS	Cell metabolism gene	MRPS2	PSMC5	0.881818253	5.53E-41
UCS	Cell metabolism gene	MRPS2	DPM2	0.884851951	1.28E-41
UCS	Cell metabolism gene	MRPS2	MTX1	0.887562486	3.32E-42
UCS	Cell metabolism gene	MRPS2	PMPCA	0.899795236	4.81E-45
UCS	Cell metabolism gene	MRPS2	PTGES2	0.903457407	5.76E-46
UCS	Cell metabolism gene	MRPS2	EXOSC4	0.905911678	1.32E-46
UCS	CGC	MRPS2	NTHL1	0.81642511	2.14E-30
UCS	CGC	MRPS2	PRCC	0.845747975	1.57E-34
UCS	CGC	MRPS2	ASPSCR1	0.90009604	4.05E-45
UCS	Epifactor	MRPS2	ZNHIT1	0.800213749	2.04E-28
UCS	Epifactor	MRPS2	LAS1L	0.814502843	3.75E-30
UCS	Epifactor	MRPS2	NOC2L	0.822421378	3.52E-31
UCS	Epifactor	MRPS2	BRMS1	0.829491036	3.85E-32
UCS	Epifactor	MRPS2	EXOSC5	0.847595541	8.09E-35
UCS	Epifactor	MRPS2	SIRT6	0.849618507	3.87E-35
UCS	Epifactor	MRPS2	PRMT1	0.850163478	3.16E-35
UCS	Epifactor	MRPS2	PRPF31	0.856361387	3.04E-36
UCS	Epifactor	MRPS2	FBL	0.857252322	2.16E-36
UCS	Epifactor	MRPS2	EXOSC4	0.905911678	1.32E-46
UCS	IUPHAR	MRPS2	SLC27A5	0.80113983	1.59E-28
UCS	IUPHAR	MRPS2	BCAT2	0.805248788	5.18E-29
UCS	IUPHAR	MRPS2	SLC25A39	0.814021641	4.32E-30
UCS	IUPHAR	MRPS2	SIRT6	0.849618507	3.87E-35
UCS	IUPHAR	MRPS2	PRMT1	0.850163478	3.16E-35
UCS	IUPHAR	MRPS2	ATP6V0B	0.857876692	1.69E-36
UCS	IUPHAR	MRPS2	HMOX2	0.880437708	1.06E-40
UCS	IUPHAR	MRPS2	PTGES2	0.903457407	5.76E-46
UCS	TF	MRPS2	ZBTB48	0.800471341	1.90E-28
UCS	TF	MRPS2	ZNF524	0.800584747	1.85E-28
UCS	TF	MRPS2	CENPB	0.834959333	6.48E-33
UCS	TF	MRPS2	NME2	0.86041666	6.20E-37
UCS	TF	MRPS2	ZNF787	0.87802508	3.27E-40
UCS	TF	MRPS2	REXO4	0.891478646	4.46E-43
UCS	TF	MRPS2	ZNF581	0.918986729	2.48E-50
UCS	TSG	MRPS2	ZBTB48	0.800471341	1.90E-28
UCS	TSG	MRPS2	NME1	0.817390571	1.61E-30
UCS	TSG	MRPS2	GSTP1	0.827041131	8.39E-32
UCS	TSG	MRPS2	BRMS1	0.829491036	3.85E-32
UCS	TSG	MRPS2	SIRT6	0.849618507	3.87E-35
UCS	TSG	MRPS2	TSSC4	0.868326351	2.39E-38
UCS	TSG	MRPS2	GADD45GIP1	0.87278402	3.48E-39
UCS	TSG	MRPS2	STUB1	0.88550152	9.27E-42
UCS	TSG	MRPS2	PHB	0.902066594	1.30E-45
UVM	TF	MRPS2	ZNF787	0.806758258	1.67E-19
UVM	TF	MRPS2	ZNF768	0.809950265	9.29E-20

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
BRCA	MRPS2	MRPS15	-2.19567551682318	0.000188684660674703
KICH	MRPS2	MRPS5	1.25108287838437	0.000249803066253662
LIHC	MRPS2	MRPS7	1.27029395477208	0.00182077236082954
STAD	MRPS2	MRPS16	-1.64208084987431	0.00239070039242506
KIRC	MRPS2	MRPS15	1.11572283836012	0.00361818577801855
PRAD	MRPS2	MRPS9	1.04379115553269	0.00496210155254694
HNSC	MRPS2	MRPS16	-2.01564621821803	0.00518989327406416
CHOL	MRPS2	MRPS6	2.57097392409939	0.0078125
LUSC	MRPS2	MRPS6	-1.26158810839259	0.013873001943322
THCA	MRPS2	MRPS15	-1.19960602422995	0.0140154883942907
ESCA	MRPS2	MRPS5	-2.15440118747854	0.0185546875
THCA	MRPS2	MRPS11	-3.10694728540962	0.0252226935182201
BLCA	MRPS2	MRPS11	-2.30276998968219	0.040130615234375
THCA	MRPS2	MRPS10	1.33413691764991	1.55171507174296e-05
LUAD	MRPS2	MRPS5	-2.20881945885927	1.77904381378076e-06
LUSC	MRPS2	MRPS9	-3.60637641031661	1.82498668910368e-07
KICH	MRPS2	MRPS35	1.14233082673341	1.96695327758789e-06
LUAD	MRPS2	MRPS9	-1.32894454884901	1.98978698949574e-05
BRCA	MRPS2	MRPS11	-1.24304977976804	2.31302509538916e-07
PRAD	MRPS2	MRPS6	1.00673230965164	3.48152859299693e-07
KIRC	MRPS2	MRPS35	-2.33452405563859	3.58581186640388e-10
LUSC	MRPS2	MRPS5	-7.65956389962319	4.27210217182982e-06
KIRC	MRPS2	MRPS6	-3.12621933743663	4.95376546353503e-10
LUSC	MRPS2	MRPS11	-2.9004097541444	5.43966600483641e-07
KICH	MRPS2	MRPS6	-1.34376231922276	7.49826431274414e-05
BRCA	MRPS2	MRPS7	-2.12787460270434	9.33194208595055e-10

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with MRPS2

ICT1, CUL5, CAND1, APP, MRPS16, MRPS9, OGDH, SSBP1, ACTA2, ESR2, C1QBP, GRSF1, CEP250, TP53, TUBGCP3, HSD17B8, TRA2A, RPL6, PTCD3, MRPS23, TPD52, MRPS28, MRPS7, ERAL1, MRPS31, MRPS11, MRPS5, MRPS14, MRPS33, TPD52L2, MRPS18C, ZC3H3, TRMT10B, ZNF707, HNRNPA1, MRPS18B, DAP3, MRPS22, MRPS35, NTRK1, HNRNPU, KLC2, Fbl, Mad2l1, Prpf3, Naa50, Nrip3, ZNF746, CDC14B, DUSP11, MRPS34, MRPS15, MRPS27, RBM42, ZBTB48, E4F1, ZNF133, AURKAIP1, RNF157, ARMC8, PCBP1, EFTUD2, SPDL1, BPLF1, HEXIM1, MEPCE, LARP7, DPF2, RECQL4, MB21D1, RPS6, MRM1, HSPD1, PDK1, TRMT61B, RC3H1, RC3H2, NR2C2, TCF7L2, ALYREF, SNRNP70, Dppa3, nsp8, CUL7, FGFR1, GRB7, PRKCI, PRKCZ, PTPRR, ESR1, IMMP2L, CELF1, ELAVL1, ZC3HAV1, IGF2BP2, MEX3B, ZC3H7A, RBM47, ACAD9, AUH, C12orf65, C17orf80, C21orf33, C6orf203, C8orf82, MCUR1, CCDC90B, CHCHD1, CLPB, COX15, CRYZ, CS, DDX28, DHX30, DIABLO, EXD2, FASTKD2, FASTKD3, FASTKD5, GFM1, GFM2, HINT2, LONP1, LRPPRC, MCU, CCDC109B, MDH2, METTL15, METTL17, MRPL11, MRPS12, MRPS26, MRRF, MTERF3, MTFMT, MTG1, MTG2, MTIF2, MTIF3, MTRF1, MTRF1L, NGRN, OTC, PMPCA, PMPCB, RMND1, RPUSD3, RPUSD4, SLC25A12, SLC25A51, SLIRP, SURF1, TACO1, TBRG4, TEFM, TFAM, C19orf52, TMEM70, TRUB2, TSFM, TUFM, VWA8, ORF4a, MAFB, Apc2, NR3C1, DNAJC15, DNAJC19, DNAJC28, HSCB, AMOT, AMOTL1, MRPS24, MRPS10, DYNLL1, YPEL5, WDR70, UFL1, DDRGK1, COX4I1, COX8A, PDHA1, ATG7, FZR1, MAP4K3, ZBTB47, MRPS6, RPL26, SRSF5, YBX1, ZNF460, RPS9, MRPS17, PRR3, YBX2, GLI4, SRSF3, FAM120A, MRPS25, ELAC2, PPOX, MCAT, NOA1, CPS1, LYPLA1, GLTSCR2, GID8, POLG, PRKRIR, RPL36AL, DARS2, SUPV3L1, MRPS21, LARS2, RBMS2, NR2F6, CECR5, CRAT, MGME1, APOBEC3D, KIAA0391, ADCK4, MRPL2, MKLN1, MCCC1, RANBP10, SRSF7, MTO1, ABT1, RSAD1, ZNF574, TMLHE, SARDH, GID4, RPL10, CYP24A1, POLRMT, ACSF3, NSUN4, TARS2, NARS2, TBC1D32, ZFYVE1, KLF12, KLF15, KLF16, KLF4,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
MRPS2	chr9	138392570	C	T	single_nucleotide_variant	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency_36	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
MRPS2	chr9	138393914	G	C	single_nucleotide_variant	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency_36	SO:0001627\|intron_variant	SO:0001627\|intron_variant
MRPS2	chr9	138395416	C	T	single_nucleotide_variant	Pathogenic	Combined_oxidative_phosphorylation_deficiency_36	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
MRPS2	chr9	138395428	G	A	single_nucleotide_variant	Pathogenic	Combined_oxidative_phosphorylation_deficiency_36	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
MRPS2	chr9	138395488	C	T	single_nucleotide_variant	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency_36	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
MRPS2	chr9	138395501	G	A	single_nucleotide_variant	Pathogenic	Combined_oxidative_phosphorylation_deficiency_36	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
MRPS2	chr9	138395657	C	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
MRPS2	chr9	138395936	G	A	single_nucleotide_variant	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency_36	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant
MRPS2	chr9	138395950	C	A	single_nucleotide_variant	Uncertain_significance	Combined_oxidative_phosphorylation_deficiency_36	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant	SO:0001583\|missense_variant,SO:0001619\|non-coding_transcript_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
MRPS2	UCS	chr9	138392884	138392884	G	A	Silent	p.K28K	3
MRPS2	PAAD	chr9	138393703	138393703	G	C	Missense_Mutation	p.K61N	3
MRPS2	PAAD	chr9	138392846	138392846	G	A	Missense_Mutation	p.A16T	3
MRPS2	SKCM	chr9	138393782	138393782	C	T	Nonsense_Mutation	p.R88*	3
MRPS2	PAAD	chr9	138395608	138395608	G	A	Missense_Mutation	p.G174S	3
MRPS2	PAAD	chr9	138395463	138395463	C	T	Silent	p.L125L	3
MRPS2	HNSC	chr9	138395504	138395504	A	T	Missense_Mutation	p.K139M	3
MRPS2	STAD	chr9	138395646	138395646	G	A	Silent	p.T186T	2
MRPS2	PAAD	chr9	138393703	138393703	G	C	Missense_Mutation		2
MRPS2	STAD	chr9	138395682	138395682	G	A	Silent	p.T198T	2
MRPS2	BLCA	chr9	138395832	138395832	C	G	Silent	p.L248L	2
MRPS2	STAD	chr9	138395799	138395799	C	T	Silent	p.P237P	2
MRPS2	PAAD	chr9	138395463	138395463	C	T	Silent		2
MRPS2	SKCM	chr9	138395565	138395565	C	T	Silent	p.A159A	2
MRPS2	STAD	chr9	138393760	138393760	C	A	Silent	p.S80S	2
MRPS2	BRCA	chr9	138395757	138395757	G	T	Silent	p.V223	2
MRPS2	PAAD	chr9	138395608	138395608	G	A	Missense_Mutation		2
MRPS2	STAD	chr9	138395577	138395577	C	T	Silent	p.G163G	2
MRPS2	ESCA	chr9	138395457	138395457	G	A	Silent		2
MRPS2	LIHC	chr9	138392921	138392921	C	T	Missense_Mutation	p.L41F	2
MRPS2	UCEC	chr9	138395466	138395466	G	A	Silent	p.Q126	2
MRPS2	UCEC	chr9	138395577	138395577	C	T	Silent	p.G163	2
MRPS2	ESCA	chr9	138395457	138395457	G	A	Silent	p.T123T	2
MRPS2	UCEC	chr9	138395784	138395784	C	A	Silent	p.I232	2
MRPS2	UCEC	chr9	138395896	138395896	C	A	Missense_Mutation	p.L270I	2
MRPS2	PCPG	chr9	138393756	138393756	T	G	Missense_Mutation		2
MRPS2	PCPG	chr9	138393756	138393756	T	G	Missense_Mutation	p.F79C	2
MRPS2	STAD	chr9	138395428	138395428	G	A	Missense_Mutation	p.D114N	2
MRPS2	ESCA	chr9	138395442	138395442	G	T	Silent	p.L118	1
MRPS2	PRAD	chr9	138395974	138395974	C	A	Missense_Mutation	p.L296M	1
MRPS2	HNSC	chr9	138395634	138395634	C	T	Silent	p.L182L	1
MRPS2	BLCA	chr9	138395755	138395755	G	A	Missense_Mutation		1
MRPS2	ESCA	chr9	138395457	138395457	G	A	Silent	p.T123	1
MRPS2	PRAD	chr9	138392971	138392971	T	A	Splice_Site		1
MRPS2	LGG	chr9	138395863	138395863	C	G	Missense_Mutation	p.R259G	1
MRPS2	PAAD	chr9	138392846	138392846	G	A	Missense_Mutation		1
MRPS2	ESCA	chr9	138395958	138395958	T	C	Silent	p.A290	1
MRPS2	READ	chr9	138395543	138395543	C	T	Missense_Mutation	p.S152L	1
MRPS2	LGG	chr9	138395910	138395910	G	T	Missense_Mutation	p.Q274H	1
MRPS2	BLCA	chr9	138395755	138395755	G	A	Missense_Mutation	p.V223M	1
MRPS2	ESCA	chr9	138392962	138392962	C	T	Silent		1
MRPS2	LGG	chr9	138395910	138395910	G	T	Missense_Mutation		1
MRPS2	ESCA	chr9	138395442	138395442	G	T	Silent		1
MRPS2	SKCM	chr9	138395412	138395412	G	A	Silent	p.G108G	1
MRPS2	LIHC	chr9	138392921	138392921	C	T	Missense_Mutation		1
MRPS2	COAD	chr9	138393813	138393813	G	A	Missense_Mutation	p.R98Q	1
MRPS2	SKCM	chr9	138395790	138395790	C	T	Silent	p.Y234Y	1
MRPS2	THCA	chr9	138392826	138392826	C	G	Missense_Mutation		1
MRPS2	COAD	chr9	138395617	138395617	A	T	Missense_Mutation	p.T177S	1
MRPS2	ESCA	chr9	138395958	138395958	T	C	Silent	p.A290A	1
MRPS2	LIHC	chr9	138395410	138395410	G	-	Frame_Shift_Del	p.G108fs	1
MRPS2	COAD	chr9	138395627	138395627	G	A	Missense_Mutation	p.R180H	1
MRPS2	SKCM	chr9	138395756	138395756	T	C	Missense_Mutation	p.V223A	1
MRPS2	LIHC	chr9	138392853	138392853	C	-	Frame_Shift_Del	p.A18fs	1
MRPS2	COAD	chr9	138395800	138395800	G	A	Missense_Mutation	p.G238S	1
MRPS2	HNSC	chr9	138395504	138395504	A	T	Missense_Mutation		1
MRPS2	SKCM	chr9	138395439	138395439	C	T	Silent	p.D117D	1
MRPS2	LUAD	chr9	138395821	138395821	G	T	Missense_Mutation	p.A245S	1
MRPS2	COAD	chr9	138395416	138395416	C	T	Missense_Mutation	p.R110C	1
MRPS2	HNSC	chr9	138395634	138395634	C	T	Silent		1
MRPS2	STAD	chr9	138392798	138392798	G	A	Missense_Mutation		1
MRPS2	BLCA	chr9	138395832	138395832	C	G	Silent		1
MRPS2	LUAD	chr9	138395820	138395820	G	T	Silent	p.L244L	1
MRPS2	UCS	chr9	138392884	138392884	G	A	Silent		1
MRPS2	ESCA	chr9	138392962	138392962	C	T	Silent	p.D54	1
MRPS2	BLCA	chr9	138392836	138392836	C	T	Silent		1
MRPS2	LUAD	chr9	138395470	138395470	G	T	Missense_Mutation	p.A128S	1

Copy number variation (CNV) of MRPS2
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across MRPS2
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
56984	LUAD	TCGA-97-8174-01A	NAA35	chr9	88577095	-	MRPS2	chr9	138392416	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type	Translation factor	Coefficent	Hazard ratio	Wald test pval	Likelihool ratio pval	Logrank test pval	# samples
LUSC	MRPS2	0.720295098837705	-0.328094291444684	0.000983883476767581	0.00101893481385836	0.00101240070021785	545
ACC	MRPS2	0.356814505017507	-1.03053922602663	0.00308175179124667	0.00575080411570088	0.0030031065737377	79
PCPG	MRPS2	0.077058885921705	-2.5631853971725	0.00310934763836724	0.00342312067777353	0.00626563601356929	185
PCPG	MRPS2	0.077058885921705	-2.5631853971725	0.00310934763836724	0.00342312067777353	0.00626563601356929	185
MESO	MRPS2	0.560293947070833	-0.579293727484006	0.00725807759755761	0.00856772222456372	0.00756180703541883	85
MESO	MRPS2	0.560293947070833	-0.579293727484006	0.00725807759755761	0.00856772222456372	0.00756180703541883	85
KIRC	MRPS2	1.34694315601725	0.297837696105133	0.0119953433641803	0.0133527076757378	0.0121224171268447	604
KIRC	MRPS2	1.34694315601725	0.297837696105133	0.0119953433641803	0.0133527076757378	0.0121224171268447	604
ACC	MRPS2	0.475188866191012	-0.7440429409409	0.0136349781560608	0.0148035418603175	0.0129232573295012	79
UCEC	MRPS2	0.52727141476128	-0.640039844494943	0.0143292668461155	0.0190242026542016	0.0132384706859973	188
BLCA	MRPS2	1.3965432244636	0.334000057920943	0.0280852560794226	0.0280338318533417	0.0279342361413315	422
LUAD	MRPS2	1.21863310569767	0.197729825456243	0.0376256728509015	0.0397561897522713	0.0375421389726825	564
LUAD	MRPS2	1.21863310569767	0.197729825456243	0.0376256728509015	0.0397561897522713	0.0375421389726825	564
LUSC	MRPS2	0.814445461882693	-0.205247812196389	0.0411674116995263	0.0397234477244221	0.0412017493802429	545
SKCM	MRPS2	1.25879301768986	0.230153339394078	0.0470076079568407	0.0487940897467856	0.0470591270172509	462
SKCM	MRPS2	1.25879301768986	0.230153339394078	0.0470076079568407	0.0487940897467856	0.0470591270172509	462
LGG	MRPS2	0.197623122420053	-1.62139348421843	4.25158256374417e-09	4.07383914209387e-08	6.45160100056977e-09	525
UVM	MRPS2	2.58339595192973	0.949104793860045	4.25720345960817e-05	3.88391645456808e-05	1.82799991305217e-05	80
LGG	MRPS2	0.426614543826448	-0.851874381105841	9.92351166063886e-06	1.18485279387426e-05	1.01647346416278e-05	525

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRP	MRPS2	0.00176379773122999	0.049
LUAD	MRPS2	0.02978925692703	0.8

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	MRPS2	0.000271990970196348	0.0087
THCA	MRPS2	0.000114741988195095	0.0038
BRCA	MRPS2	0.00104117587531395	0.032
OV	MRPS2	0.0145731893915155	0.44
SARC	MRPS2	0.0193185062403647	0.56

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C4693722	COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 36	1	GENOMICS_ENGLAND;UNIPROT