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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPL26L1 (NCBI Gene ID:51121)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPL26L1
	Gene ID: 51121
	Gene Symbol	RPL26L1
	Gene ID	51121
	Gene Name	ribosomal protein L26 like 1
	Synonyms	RPL26P1
	Cytomap	5q35.1
	Type of Gene	protein-coding
	Description	60S ribosomal protein L26-like 1large ribosomal subunit protein uL24-like 1ribosomal protein L26 homologribosomal protein L26 pseudogene 1
	Modification date	20200313
	UniProtAcc	Q9UNX3

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene

Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25

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Translation Studies in PubMed

We searched PubMed using 'RPL26L1[title] AND translation [title] AND human.'

Gene	Title	PMID
RPL26L1	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000265100	172395461	172395602	In-frame
ENST00000519239	172395461	172395602	In-frame
ENST00000519974	172395461	172395602	In-frame
ENST00000521476	172395461	172395602	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000519239	172395461	172395602	696	233	373	145	56	103
ENST00000519974	172395461	172395602	712	251	391	145	56	103
ENST00000265100	172395461	172395602	739	223	363	145	56	103
ENST00000521476	172395461	172395602	759	293	433	145	56	103

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
Q9UNX3	56	103	1	145	Chain	ID=PRO_0000130791;Note=60S ribosomal protein L26-like 1
Q9UNX3	56	103	1	145	Chain	ID=PRO_0000130791;Note=60S ribosomal protein L26-like 1
Q9UNX3	56	103	1	145	Chain	ID=PRO_0000130791;Note=60S ribosomal protein L26-like 1
Q9UNX3	56	103	1	145	Chain	ID=PRO_0000130791;Note=60S ribosomal protein L26-like 1

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
LIHC	RPL26L1	1.01687204148728	0.0029470290722562
LUSC	RPL26L1	-5.04140575782936	1.45608838900009e-05
LUAD	RPL26L1	-5.07600585244146	1.73122747932354e-05

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
ESCA	RPL26L1	-0.100388957	0.000449471
SARC	RPL26L1	0.4542775	0.015134549

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPL26L1 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
GBM	Cell metabolism gene	RPL26L1	TBCA	0.807862982	6.97E-41
GBM	Cell metabolism gene	RPL26L1	PSMA5	0.810479522	2.45E-41
GBM	Cell metabolism gene	RPL26L1	PSMB4	0.810561079	2.37E-41
GBM	Cell metabolism gene	RPL26L1	GEMIN6	0.813543096	7.05E-42
GBM	Cell metabolism gene	RPL26L1	PFDN1	0.840075606	5.06E-47
GBM	Cell metabolism gene	RPL26L1	PSMB3	0.847397399	1.31E-48
GBM	Cell metabolism gene	RPL26L1	SNRPG	0.851704259	1.39E-49
GBM	Epifactor	RPL26L1	DPY30	0.851058638	1.96E-49
GBM	IUPHAR	RPL26L1	PDZD11	0.821359838	2.64E-43
GBM	TSG	RPL26L1	HINT1	0.827584971	1.72E-44
KICH	Cell metabolism gene	RPL26L1	PFDN1	0.824701738	9.52E-24
KICH	Cell metabolism gene	RPL26L1	TBCA	0.824847332	9.21E-24
TGCT	Cell metabolism gene	RPL26L1	PSMA5	0.803431272	1.66E-36
TGCT	TSG	RPL26L1	PHB	0.826050826	3.45E-40
THCA	TSG	RPL26L1	PARK7	0.810588979	1.42E-134
THYM	Cell metabolism gene	RPL26L1	TOMM5	0.801191243	1.57E-28
THYM	Cell metabolism gene	RPL26L1	EXOSC5	0.801274136	1.53E-28
THYM	Cell metabolism gene	RPL26L1	EXOSC4	0.801604177	1.40E-28
THYM	Cell metabolism gene	RPL26L1	ITPA	0.809035909	1.80E-29
THYM	Cell metabolism gene	RPL26L1	PAFAH1B3	0.809180408	1.73E-29
THYM	Cell metabolism gene	RPL26L1	MED27	0.809989166	1.38E-29
THYM	Cell metabolism gene	RPL26L1	PSMB6	0.810470921	1.20E-29
THYM	Cell metabolism gene	RPL26L1	PSMA7	0.810704152	1.12E-29
THYM	Cell metabolism gene	RPL26L1	DGUOK	0.810973948	1.04E-29
THYM	Cell metabolism gene	RPL26L1	HMOX2	0.811355119	9.32E-30
THYM	Cell metabolism gene	RPL26L1	PSMA4	0.811627125	8.62E-30
THYM	Cell metabolism gene	RPL26L1	APRT	0.813043363	5.73E-30
THYM	Cell metabolism gene	RPL26L1	TIMM13	0.814469644	3.79E-30
THYM	Cell metabolism gene	RPL26L1	TXN	0.814597437	3.65E-30
THYM	Cell metabolism gene	RPL26L1	ACOT8	0.814865177	3.38E-30
THYM	Cell metabolism gene	RPL26L1	PSMB2	0.815282998	2.99E-30
THYM	Cell metabolism gene	RPL26L1	NANS	0.818773871	1.06E-30
THYM	Cell metabolism gene	RPL26L1	TOMM22	0.819569898	8.37E-31
THYM	Cell metabolism gene	RPL26L1	SNRPB	0.821838991	4.21E-31
THYM	Cell metabolism gene	RPL26L1	PSMC1	0.822490935	3.45E-31
THYM	Cell metabolism gene	RPL26L1	GEMIN7	0.823706269	2.37E-31
THYM	Cell metabolism gene	RPL26L1	COX17	0.823752798	2.34E-31
THYM	Cell metabolism gene	RPL26L1	LSM3	0.824742433	1.72E-31
THYM	Cell metabolism gene	RPL26L1	TIMM8B	0.826305117	1.06E-31
THYM	Cell metabolism gene	RPL26L1	GSS	0.829669842	3.64E-32
THYM	Cell metabolism gene	RPL26L1	TIMM50	0.829691253	3.61E-32
THYM	Cell metabolism gene	RPL26L1	SNRPD2	0.829867936	3.41E-32
THYM	Cell metabolism gene	RPL26L1	EBP	0.834649695	7.18E-33
THYM	Cell metabolism gene	RPL26L1	MTX1	0.835530092	5.36E-33
THYM	Cell metabolism gene	RPL26L1	LSM4	0.836127691	4.39E-33
THYM	Cell metabolism gene	RPL26L1	PSMB7	0.838617959	1.89E-33
THYM	Cell metabolism gene	RPL26L1	CYC1	0.839243094	1.53E-33
THYM	Cell metabolism gene	RPL26L1	TIMM17B	0.841490768	7.05E-34
THYM	Cell metabolism gene	RPL26L1	SEC61G	0.84244206	5.06E-34
THYM	Cell metabolism gene	RPL26L1	PSMB3	0.844217117	2.71E-34
THYM	Cell metabolism gene	RPL26L1	POLR2I	0.844689473	2.29E-34
THYM	Cell metabolism gene	RPL26L1	POLR2H	0.84624276	1.32E-34
THYM	Cell metabolism gene	RPL26L1	GEMIN6	0.846551026	1.18E-34
THYM	Cell metabolism gene	RPL26L1	TBCA	0.84898787	4.87E-35
THYM	Cell metabolism gene	RPL26L1	WBSCR22	0.849348264	4.27E-35
THYM	Cell metabolism gene	RPL26L1	PSMC4	0.850176853	3.15E-35
THYM	Cell metabolism gene	RPL26L1	NME1	0.854891431	5.36E-36
THYM	Cell metabolism gene	RPL26L1	HSD17B10	0.858766312	1.19E-36
THYM	Cell metabolism gene	RPL26L1	PSMD4	0.866678128	4.79E-38
THYM	Cell metabolism gene	RPL26L1	PSMB4	0.875780617	9.13E-40
THYM	Cell metabolism gene	RPL26L1	ATP5G1	0.883129347	2.95E-41
THYM	Cell metabolism gene	RPL26L1	SNRPE	0.883406142	2.58E-41
THYM	Cell metabolism gene	RPL26L1	TOMM40	0.884236571	1.72E-41
THYM	CGC	RPL26L1	COX6C	0.872188946	4.52E-39
THYM	Epifactor	RPL26L1	EXOSC5	0.801274136	1.53E-28
THYM	Epifactor	RPL26L1	EXOSC4	0.801604177	1.40E-28
THYM	Epifactor	RPL26L1	DPY30	0.806318213	3.86E-29
THYM	Epifactor	RPL26L1	PRPF31	0.809826887	1.44E-29
THYM	Epifactor	RPL26L1	CDK5	0.873927111	2.10E-39
THYM	IUPHAR	RPL26L1	PSMB6	0.810470921	1.20E-29
THYM	IUPHAR	RPL26L1	HMOX2	0.811355119	9.32E-30
THYM	IUPHAR	RPL26L1	PSMB2	0.815282998	2.99E-30
THYM	IUPHAR	RPL26L1	UCHL3	0.836183422	4.31E-33
THYM	IUPHAR	RPL26L1	PPIA	0.862062529	3.20E-37
THYM	IUPHAR	RPL26L1	CDK5	0.873927111	2.10E-39
THYM	Kinase	RPL26L1	CDK5	0.873927111	2.10E-39
THYM	TF	RPL26L1	DNTTIP1	0.821625311	4.49E-31
THYM	TSG	RPL26L1	DIABLO	0.800229704	2.03E-28
THYM	TSG	RPL26L1	PARK7	0.800568673	1.85E-28
THYM	TSG	RPL26L1	PINX1	0.815311108	2.96E-30
THYM	TSG	RPL26L1	NME1	0.854891431	5.36E-36
UCS	Cell metabolism gene	RPL26L1	TOMM5	0.801191243	1.57E-28
UCS	Cell metabolism gene	RPL26L1	EXOSC5	0.801274136	1.53E-28
UCS	Cell metabolism gene	RPL26L1	EXOSC4	0.801604177	1.40E-28
UCS	Cell metabolism gene	RPL26L1	ITPA	0.809035909	1.80E-29
UCS	Cell metabolism gene	RPL26L1	PAFAH1B3	0.809180408	1.73E-29
UCS	Cell metabolism gene	RPL26L1	MED27	0.809989166	1.38E-29
UCS	Cell metabolism gene	RPL26L1	PSMB6	0.810470921	1.20E-29
UCS	Cell metabolism gene	RPL26L1	PSMA7	0.810704152	1.12E-29
UCS	Cell metabolism gene	RPL26L1	DGUOK	0.810973948	1.04E-29
UCS	Cell metabolism gene	RPL26L1	HMOX2	0.811355119	9.32E-30
UCS	Cell metabolism gene	RPL26L1	PSMA4	0.811627125	8.62E-30
UCS	Cell metabolism gene	RPL26L1	APRT	0.813043363	5.73E-30
UCS	Cell metabolism gene	RPL26L1	TIMM13	0.814469644	3.79E-30
UCS	Cell metabolism gene	RPL26L1	TXN	0.814597437	3.65E-30
UCS	Cell metabolism gene	RPL26L1	ACOT8	0.814865177	3.38E-30
UCS	Cell metabolism gene	RPL26L1	PSMB2	0.815282998	2.99E-30
UCS	Cell metabolism gene	RPL26L1	NANS	0.818773871	1.06E-30
UCS	Cell metabolism gene	RPL26L1	TOMM22	0.819569898	8.37E-31
UCS	Cell metabolism gene	RPL26L1	SNRPB	0.821838991	4.21E-31
UCS	Cell metabolism gene	RPL26L1	PSMC1	0.822490935	3.45E-31
UCS	Cell metabolism gene	RPL26L1	GEMIN7	0.823706269	2.37E-31
UCS	Cell metabolism gene	RPL26L1	COX17	0.823752798	2.34E-31
UCS	Cell metabolism gene	RPL26L1	LSM3	0.824742433	1.72E-31
UCS	Cell metabolism gene	RPL26L1	TIMM8B	0.826305117	1.06E-31
UCS	Cell metabolism gene	RPL26L1	GSS	0.829669842	3.64E-32
UCS	Cell metabolism gene	RPL26L1	TIMM50	0.829691253	3.61E-32
UCS	Cell metabolism gene	RPL26L1	SNRPD2	0.829867936	3.41E-32
UCS	Cell metabolism gene	RPL26L1	EBP	0.834649695	7.18E-33
UCS	Cell metabolism gene	RPL26L1	MTX1	0.835530092	5.36E-33
UCS	Cell metabolism gene	RPL26L1	LSM4	0.836127691	4.39E-33
UCS	Cell metabolism gene	RPL26L1	PSMB7	0.838617959	1.89E-33
UCS	Cell metabolism gene	RPL26L1	CYC1	0.839243094	1.53E-33
UCS	Cell metabolism gene	RPL26L1	TIMM17B	0.841490768	7.05E-34
UCS	Cell metabolism gene	RPL26L1	SEC61G	0.84244206	5.06E-34
UCS	Cell metabolism gene	RPL26L1	PSMB3	0.844217117	2.71E-34
UCS	Cell metabolism gene	RPL26L1	POLR2I	0.844689473	2.29E-34
UCS	Cell metabolism gene	RPL26L1	POLR2H	0.84624276	1.32E-34
UCS	Cell metabolism gene	RPL26L1	GEMIN6	0.846551026	1.18E-34
UCS	Cell metabolism gene	RPL26L1	TBCA	0.84898787	4.87E-35
UCS	Cell metabolism gene	RPL26L1	WBSCR22	0.849348264	4.27E-35
UCS	Cell metabolism gene	RPL26L1	PSMC4	0.850176853	3.15E-35
UCS	Cell metabolism gene	RPL26L1	NME1	0.854891431	5.36E-36
UCS	Cell metabolism gene	RPL26L1	HSD17B10	0.858766312	1.19E-36
UCS	Cell metabolism gene	RPL26L1	PSMD4	0.866678128	4.79E-38
UCS	Cell metabolism gene	RPL26L1	PSMB4	0.875780617	9.13E-40
UCS	Cell metabolism gene	RPL26L1	ATP5G1	0.883129347	2.95E-41
UCS	Cell metabolism gene	RPL26L1	SNRPE	0.883406142	2.58E-41
UCS	Cell metabolism gene	RPL26L1	TOMM40	0.884236571	1.72E-41
UCS	CGC	RPL26L1	COX6C	0.872188946	4.52E-39
UCS	Epifactor	RPL26L1	EXOSC5	0.801274136	1.53E-28
UCS	Epifactor	RPL26L1	EXOSC4	0.801604177	1.40E-28
UCS	Epifactor	RPL26L1	DPY30	0.806318213	3.86E-29
UCS	Epifactor	RPL26L1	PRPF31	0.809826887	1.44E-29
UCS	Epifactor	RPL26L1	CDK5	0.873927111	2.10E-39
UCS	IUPHAR	RPL26L1	PSMB6	0.810470921	1.20E-29
UCS	IUPHAR	RPL26L1	HMOX2	0.811355119	9.32E-30
UCS	IUPHAR	RPL26L1	PSMB2	0.815282998	2.99E-30
UCS	IUPHAR	RPL26L1	UCHL3	0.836183422	4.31E-33
UCS	IUPHAR	RPL26L1	PPIA	0.862062529	3.20E-37
UCS	IUPHAR	RPL26L1	CDK5	0.873927111	2.10E-39
UCS	Kinase	RPL26L1	CDK5	0.873927111	2.10E-39
UCS	TF	RPL26L1	DNTTIP1	0.821625311	4.49E-31
UCS	TSG	RPL26L1	DIABLO	0.800229704	2.03E-28
UCS	TSG	RPL26L1	PARK7	0.800568673	1.85E-28
UCS	TSG	RPL26L1	PINX1	0.815311108	2.96E-30
UCS	TSG	RPL26L1	NME1	0.854891431	5.36E-36
UVM	Cell metabolism gene	RPL26L1	PSMA3	0.810962741	7.70E-20

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
BLCA	RPL26L1	RPL10A	-6.44657805140652	0.000164031982421875
HNSC	RPL26L1	RPL6	2.22149016292113	0.000172794781747143
BLCA	RPL26L1	RPL5	-3.50581551367555	0.00026702880859375
STAD	RPL26L1	RPL5	2.24361928856279	0.000433447770774365
LIHC	RPL26L1	RPL8	-4.84588284974558	0.00110314154326131
LIHC	RPL26L1	RPL22	1.69944741480638	0.00235963995691637
BLCA	RPL26L1	RPL22	-1.66398106452175	0.002838134765625
HNSC	RPL26L1	RPL27	-1.15368387664859	0.00329169979568178
STAD	RPL26L1	RPL34	1.945601737258	0.00471024587750435
ESCA	RPL26L1	RPL15	1.76629417535644	0.0048828125
THCA	RPL26L1	RPL27	-1.83254033854825	0.00492925389458784
LUAD	RPL26L1	RPL27	-3.66906241466368	0.00773628245812536
KICH	RPL26L1	RPL10A	1.57107790372051	0.0124664902687073
THCA	RPL26L1	FAU	1.18509450470262	0.0152379297688856
KICH	RPL26L1	RPL5	1.79380241489629	0.0219083428382874
STAD	RPL26L1	RPL27	-1.4564848176927	0.0279771662317216
KIRP	RPL26L1	FAU	-1.04355048353271	0.0309218638576567
UCEC	RPL26L1	RPL22	-1.25950871113125	0.046875
KIRC	RPL26L1	FAU	-2.50135425883801	1.33253564327251e-08
LUAD	RPL26L1	RPL30	-1.98579595284099	1.50488235365288e-05
KIRP	RPL26L1	RPL27	-1.94671018280482	2.0815059542656e-07
KIRC	RPL26L1	RPL10A	-2.3455028090226	5.61779186490163e-09
KIRC	RPL26L1	RPL8	-1.18252459971773	5.64962994208288e-07
KIRP	RPL26L1	RPL8	-1.53003692350119	6.0301274061203e-05
BRCA	RPL26L1	RPL22	-2.59980502511221	6.9057331042677e-19
KIRC	RPL26L1	RPL27	-1.37952962808509	7.04452987764158e-08
KIRP	RPL26L1	RPL6	-1.52645217188093	7.40401446819306e-05
KIRP	RPL26L1	RPL22	1.74965489233405	7.71600753068924e-06
LUSC	RPL26L1	RPL30	-2.27386662283158	9.09971457907932e-05
KIRC	RPL26L1	RPL30	-1.65763742142219	9.40007073737459e-12

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPL26L1

CUL3, CUL4B, CUL5, CUL1, COPS5, CAND1, MAGOH, PAN2, IGSF8, ICAM1, PARK2, HNRNPM, IGF2BP3, MRE11A, QARS, RFC4, C14orf166, RTCB, DDX1, DHX9, RPL27, TP53, TUBG1, NOL12, RPL10A, RPL13, RPL14, ZNF22, FMR1NB, NSA2, RPL8, DHX8, ZNF501, EAF1, TRA2A, RPL6, NIFK, NPM1, RPS2, RPSA, THAP7, ZC3H3, FGF10, RPS8, ZC3H8, TRMT10B, ZBTB38, BYSL, PRR11, RBM4B, ZSCAN26, ZRANB2, ILF2, ZNF317, MRPS30, MRPL47, ZRSR2, ATP1B3, RPL12, RPL15, RPL17, RPL18, RPL10, RPL21, RPL22, RPL23, RPL3, RPL4, RPL7A, RPS13, RPS18, RPL27A, RPL30, RPL34, RPL35, RPL36, RPL5, RPLP2, RPS15, RPS16, LOC101929876, RPS26, RPS29, RPS6, RPS9, NUP43, NUP133, NUP160, ACAD9, Srp72, Kat8, MCM2, OTUB1, CRBN, ZNF746, ZNF512, ZCRB1, MAK16, ZC3HAV1, RPL37A, E4F1, H2AFX, KIAA0020, RPF1, RBM34, SART3, RBM4, ZNF324B, CNBP, PRDM5, CPNE4, CDX1, RPL7, WDR46, BHLHA15, ZBTB48, HIST1H1T, MAGEB10, PDGFB, ZNF169, GPATCH4, SRP68, H2AFY2, PLEKHO1, ZNF692, RPS14, DGCR8, RRP8, GLTSCR2, FGF8, NXF2, RPL28, KNOP1, ZNF274, NCL, HIST1H1E, ZSCAN31, STAU1, RSBN1, ZNF71, SYNCRIP, CRP, ZNF286A, CCDC59, RPS7, MECP2, PPAN, FGF3, RPS11, RPL9, ZNF490, DDX31, PRPF3, PRPF4, ALYREF, LSM4, LSM8, PPIH, OLA1, RPL32, COX15, FBXO7, TRIM14, WDR77, LARP7, RIOK1, ESR2, HEXIM1, MEPCE, RECQL4, CDK9, FBL, AURKAIP1, SNRNP70, Dppa3, BIRC3, WWP2, MATR3, APP, FBXW8, OBSL1, CUL7, ZC3H18, ORF3a, S, CIT, ANLN, AURKB, CHMP4C, ECT2, KIF14, KIF20A, KIF23, PRC1, MKI67, LRRC59, N, RBM39, SETD8, DAW1, HIST1H2AI, RALY, CBX1, HMGN2, S100A9, RPL35A, S100A7, S100A8, DDRGK1, PAGE4, NUDCD2, ZBTB2, IMP4, ZNF616, RPS3, RPS3A, NOC3L, NOC2L, RSL1D1, PATZ1, NEIL1, DHX57, RPL19, SURF6, YBX2, YTHDC2, PNMAL1, ZNF48, RPL31, OASL, MRPL30, MRPL18, UTP23, RNF151, HNRNPUL2, NVL, CCDC106, KRR1, RPLP0, PTPRB, RPS24, ZNF467, KAL1, RBM28, SRBD1, DDX24, HIST1H1B, HIST2H2AA4, RRP1B, ZKSCAN8, SPATS2L, WDR36, HIST1H2AB, TRIP4, TRMT1L, HIST1H2AM, HIST2H2AC, SPATS2, MRPL52, PRR3, AKAP17A, MINA, RPL36AL, LIN28B, GOLGA8A, HIST1H1D, H1FOO, BMS1, RBM19, PURG, C8orf33, MYBBP1A, PRKRA, ZCCHC6, URB1, DDX55, NUPL2, YTHDF1, HNRNPLL, RPS10, FTSJ3, MRPS31, RPS19, ZNF724P, ZNF483, PABPC5, NOP2, SRPK2, CTCF, GNL2, LIN28A, TAF1D, DAXX, ZNF275, DDX21, ARHGEF2, MAP7, SRSF1, SRSF4, SRSF3, THAP3, ZNF320, RPL26, PARN, GTPBP10, ZBTB47, LYAR, RPSAP58, WDR3, TFB1M, ZNF485, APOBEC3C, IL17B, BUD13, RIOK2, MRPL2, GTPBP4, ZNF346, BLM, BRD1, FGF17, NAT10, HDLBP, ELAVL4, KIF2A, FGFBP1, ZNF653, NOL10, RPL13A, SRSF5, SRSF6, H1FNT, RPL23A, NPM3, RPL23AP32, BBX, ZNF689, RPS5, MRPS9, LLPH, CCDC140, CCDC137, SRP14, GLI4, PDCD11, ADARB1, RPL7L1, MRPS7, ABT1, SRPK3, RPL37, CBX6, YBX1, ILF3, DHX36, FGF13, ASCC2, RBMS2, RSBN1L, H2AFB3, REXO4, MRPL12, THUMPD1, SET, MRPS34, RPL11, HIST1H1A, GSPT2, RPL18A, APOBEC3D, ZC3H10, HIST1H2AE, AUNIP, KIAA1522, ZNF574, MAGEB2, ZNF668, FBXW7, Eif4a2, DPP4, OPTN, KLF12, KLF16, KLF3, KLF5, KLF8, KLF9, LHX1, LHX2, LHX4, KLF15,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPL26L1	STAD	chr5	172396461	172396461	C	A	Missense_Mutation	p.L119I	6
RPL26L1	READ	chr5	172395521	172395521	G	T	Missense_Mutation	p.K76N	3
RPL26L1	BLCA	chr5	172386963	172386963	C	T	Silent	p.I29I	3
RPL26L1	BLCA	chr5	172386879	172386879	G	A	Translation_Start_Site	p.M1I	3
RPL26L1	KIRP	chr5	172396527	172396527	G	A	Missense_Mutation	p.E141K	3
RPL26L1	ESCA	chr5	172387036	172387036	G	A	Missense_Mutation	p.E54K	3
RPL26L1	ESCA	chr5	172396449	172396449	C	T	Missense_Mutation	p.R115W	3
RPL26L1	UCEC	chr5	172395540	172395540	G	A	Missense_Mutation	p.E83K	3
RPL26L1	BLCA	chr5	172386933	172386933	C	T	Silent	p.F19F	2
RPL26L1	UCEC	chr5	172395553	172395553	G	A	Missense_Mutation	p.R87H	2
RPL26L1	UCEC	chr5	172396497	172396497	G	T	Nonsense_Mutation	p.E131*	2
RPL26L1	BLCA	chr5	172396492	172396492	G	C	Missense_Mutation	p.G129A	2
RPL26L1	STAD	chr5	172386991	172386991	C	T	Missense_Mutation	p.R39W	2
RPL26L1	STAD	chr5	172386967	172386967	T	C	Missense_Mutation	p.S31P	2
RPL26L1	LUAD	chr5	172395553	172395553	G	T	Missense_Mutation	p.R87L	2
RPL26L1	LUAD	chr5	172396539	172396539	G	A	Missense_Mutation	p.E145K	2
RPL26L1	ESCA	chr5	172387036	172387036	G	A	Missense_Mutation		2
RPL26L1	ESCA	chr5	172396449	172396449	C	T	Missense_Mutation		2
RPL26L1	HNSC	chr5	172386987	172386987	G	C	Missense_Mutation	p.E37D	2
RPL26L1	KIRC	chr5	172386880	172386880	A	C	Missense_Mutation	p.K2Q	1
RPL26L1	SKCM	chr5	172396499	172396499	G	A	Silent	p.E131E	1
RPL26L1	KIRC	chr5	172395572	172395572	A	G	Silent	p.T93T	1
RPL26L1	SKCM	chr5	172395530	172395530	C	T	Silent	p.V79V	1
RPL26L1	UVM	chr5	172395506	172395506	C	G	Silent	p.V71V	1
RPL26L1	SKCM	chr5	172386889	172386889	C	T	Missense_Mutation	p.P5S	1
RPL26L1	LGG	chr5	172387010	172387010	G	A	Missense_Mutation	p.R45H	1
RPL26L1	BLCA	chr5	172395499	172395499	A	T	Missense_Mutation	p.K69M	1
RPL26L1	LIHC	chr5	172386869	172386869	G	T	Missense_Mutation		1
RPL26L1	THCA	chr5	172395491	172395491	A	C	Missense_Mutation		1
RPL26L1	LUSC	chr5	172396424	172396424	C	T	Silent	p.I106I	1
RPL26L1	BLCA	chr5	172386933	172386933	C	T	Silent		1
RPL26L1	THYM	chr5	172395565	172395565	A	G	Missense_Mutation	p.N91S	1
RPL26L1	PAAD	chr5	172386920	172386920	G	T	Missense_Mutation	p.R15L	1
RPL26L1	BLCA	chr5	172386963	172386963	C	T	Silent		1
RPL26L1	THYM	chr5	172395565	172395565	A	G	Missense_Mutation		1
RPL26L1	HNSC	chr5	172386987	172386987	G	C	Missense_Mutation		1
RPL26L1	PAAD	chr5	172386920	172386920	G	T	Missense_Mutation		1
RPL26L1	BLCA	chr5	172386879	172386879	G	A	Translation_Start_Site		1

Copy number variation (CNV) of RPL26L1
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RPL26L1
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5846	N/A	CB054890	ARFGAP3	chr22	43246573	-	RPL26L1	chr5	172396774	-
90708	N/A	CD579936	RPL26L1	chr5	172396617	+	DSCAML1	chr11	117395229	+
100586	N/A	BE835787	RPL26L1	chr5	172396508	-	SKIL	chr3	170106163	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LIHC	RPL26L1	0.00411200609204101	0.12
MESO	RPL26L1	0.00626512396912412	0.17
DLBC	RPL26L1	0.0168326098953598	0.44
KIRC	RPL26L1	0.0333007210611366	0.83

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	RPL26L1	0.00204098998326466	0.067
LGG	RPL26L1	0.00249545877367535	0.08
BRCA	RPL26L1	0.0227787975135685	0.68
CHOL	RPL26L1	0.00261092893160919	0.081

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source