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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: TACO1 (NCBI Gene ID:51204)

Gene Summary

Gene Summary

Gene Information	Gene Name: TACO1
	Gene ID: 51204
	Gene Symbol	TACO1
	Gene ID	51204
	Gene Name	translational activator of cytochrome c oxidase I
	Synonyms	CCDC44
	Cytomap	17q23.3
	Type of Gene	protein-coding
	Description	translational activator of cytochrome c oxidase 1clone HQ0477 PRO0477pcoiled-coil domain-containing protein 44translational activator of COX Itranslational activator of mitochondrially encoded cytochrome c oxidase I
	Modification date	20200313
	UniProtAcc	Q9BSH4

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0032543	Mitochondrial translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
TACO1	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'TACO1[title] AND translation [title] AND human.'

Gene	Title	PMID
TACO1	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000258975	61683672	61683800	Frame-shift

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
CHOL	TACO1	-8.87050800605738	0.00390625
BRCA	TACO1	-2.33803140550261	7.20141361596004e-14
LUAD	TACO1	-4.94497725815155	9.56799412915172e-10

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
TGCT	TACO1	0.102656956	0.032916795
LUAD	TACO1	-0.188628526	0.04838147

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with TACO1 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
BRCA	Cell metabolism gene	TACO1	PSMC5	0.838424066	8e-323
CHOL	Cell metabolism gene	TACO1	GSTO1	0.800334386	4.18E-11
CHOL	Cell metabolism gene	TACO1	PMPCA	0.8030859	3.19E-11
CHOL	Cell metabolism gene	TACO1	HSD17B10	0.803685244	3.01E-11
CHOL	Cell metabolism gene	TACO1	ADI1	0.804264672	2.84E-11
CHOL	Cell metabolism gene	TACO1	IVD	0.804959724	2.65E-11
CHOL	Cell metabolism gene	TACO1	ACY1	0.805514611	2.51E-11
CHOL	Cell metabolism gene	TACO1	GLYCTK	0.810140723	1.57E-11
CHOL	Cell metabolism gene	TACO1	SUCLG2	0.81088018	1.46E-11
CHOL	Cell metabolism gene	TACO1	PEMT	0.811479354	1.37E-11
CHOL	Cell metabolism gene	TACO1	KHK	0.814872413	9.61E-12
CHOL	Cell metabolism gene	TACO1	CRAT	0.815199096	9.28E-12
CHOL	Cell metabolism gene	TACO1	ACACB	0.817584193	7.20E-12
CHOL	Cell metabolism gene	TACO1	MLYCD	0.820077387	5.50E-12
CHOL	Cell metabolism gene	TACO1	PCCB	0.820249295	5.40E-12
CHOL	Cell metabolism gene	TACO1	FAH	0.823538692	3.76E-12
CHOL	Cell metabolism gene	TACO1	MMAB	0.827213728	2.49E-12
CHOL	Cell metabolism gene	TACO1	NFS1	0.828519366	2.14E-12
CHOL	Cell metabolism gene	TACO1	PCYT2	0.828641468	2.11E-12
CHOL	Cell metabolism gene	TACO1	HMGCL	0.830464295	1.71E-12
CHOL	Cell metabolism gene	TACO1	QDPR	0.835538065	9.40E-13
CHOL	Cell metabolism gene	TACO1	GSTK1	0.848603052	1.82E-13
CHOL	Cell metabolism gene	TACO1	HAGH	0.850135978	1.49E-13
CHOL	Cell metabolism gene	TACO1	GOT2	0.852219829	1.12E-13
CHOL	Cell metabolism gene	TACO1	SLC25A1	0.857185263	5.68E-14
CHOL	Cell metabolism gene	TACO1	PNPO	0.858393746	4.79E-14
CHOL	Cell metabolism gene	TACO1	ACADS	0.859814759	3.91E-14
CHOL	Cell metabolism gene	TACO1	ASL	0.860611164	3.49E-14
CHOL	Cell metabolism gene	TACO1	SUCLG1	0.867242167	1.31E-14
CHOL	Cell metabolism gene	TACO1	EBP	0.869469243	9.34E-15
CHOL	Cell metabolism gene	TACO1	SDHB	0.871312793	7.01E-15
CHOL	Cell metabolism gene	TACO1	SLC25A10	0.875694736	3.48E-15
CHOL	Cell metabolism gene	TACO1	ECHS1	0.885066311	7.12E-16
CHOL	CGC	TACO1	SDHB	0.871312793	7.01E-15
CHOL	IUPHAR	TACO1	GSTO1	0.800334386	4.18E-11
CHOL	IUPHAR	TACO1	MTCH2	0.808022476	1.95E-11
CHOL	IUPHAR	TACO1	ACACB	0.817584193	7.20E-12
CHOL	IUPHAR	TACO1	MLYCD	0.820077387	5.50E-12
CHOL	IUPHAR	TACO1	PCCB	0.820249295	5.40E-12
CHOL	IUPHAR	TACO1	PEPD	0.848605765	1.82E-13
CHOL	IUPHAR	TACO1	SLC25A1	0.857185263	5.68E-14
CHOL	IUPHAR	TACO1	SLC25A10	0.875694736	3.48E-15
CHOL	TF	TACO1	ATF5	0.809651573	1.65E-11
CHOL	TSG	TACO1	ACY1	0.805514611	2.51E-11
CHOL	TSG	TACO1	SDHB	0.871312793	7.01E-15
DLBC	Cell metabolism gene	TACO1	GSTZ1	0.805412191	5.11E-12
DLBC	Cell metabolism gene	TACO1	GFER	0.807652393	4.02E-12
DLBC	Cell metabolism gene	TACO1	HSD17B10	0.807683137	4.00E-12
DLBC	Cell metabolism gene	TACO1	PSMA6	0.808385376	3.71E-12
DLBC	Cell metabolism gene	TACO1	PSMB5	0.808746021	3.57E-12
DLBC	Cell metabolism gene	TACO1	LYPLA2	0.809639111	3.24E-12
DLBC	Cell metabolism gene	TACO1	SNRPD2	0.809845159	3.17E-12
DLBC	Cell metabolism gene	TACO1	LSM3	0.810515984	2.94E-12
DLBC	Cell metabolism gene	TACO1	SNRPB	0.810842876	2.84E-12
DLBC	Cell metabolism gene	TACO1	FPGS	0.811359068	2.68E-12
DLBC	Cell metabolism gene	TACO1	DPM3	0.81268462	2.31E-12
DLBC	Cell metabolism gene	TACO1	OAZ1	0.812967185	2.24E-12
DLBC	Cell metabolism gene	TACO1	DHRS4L2	0.81372455	2.06E-12
DLBC	Cell metabolism gene	TACO1	POLR2L	0.813925083	2.01E-12
DLBC	Cell metabolism gene	TACO1	NME2	0.814194892	1.95E-12
DLBC	Cell metabolism gene	TACO1	VKORC1	0.815294371	1.73E-12
DLBC	Cell metabolism gene	TACO1	PTGES2	0.816082477	1.58E-12
DLBC	Cell metabolism gene	TACO1	MVD	0.816859091	1.45E-12
DLBC	Cell metabolism gene	TACO1	LSM4	0.81854054	1.19E-12
DLBC	Cell metabolism gene	TACO1	PSME2	0.819064252	1.12E-12
DLBC	Cell metabolism gene	TACO1	TIMM50	0.820287004	9.74E-13
DLBC	Cell metabolism gene	TACO1	TXNRD2	0.820325056	9.70E-13
DLBC	Cell metabolism gene	TACO1	PGLS	0.823657766	6.55E-13
DLBC	Cell metabolism gene	TACO1	PSMB7	0.824637942	5.83E-13
DLBC	Cell metabolism gene	TACO1	ACOT8	0.82563149	5.17E-13
DLBC	Cell metabolism gene	TACO1	POLR2I	0.828479582	3.66E-13
DLBC	Cell metabolism gene	TACO1	GALK1	0.830901183	2.71E-13
DLBC	Cell metabolism gene	TACO1	MED16	0.832164552	2.32E-13
DLBC	Cell metabolism gene	TACO1	GEMIN7	0.832193696	2.31E-13
DLBC	Cell metabolism gene	TACO1	TALDO1	0.832992817	2.09E-13
DLBC	Cell metabolism gene	TACO1	GUK1	0.836704301	1.30E-13
DLBC	Cell metabolism gene	TACO1	MIF	0.840462039	7.93E-14
DLBC	Cell metabolism gene	TACO1	PSMC1	0.840945514	7.43E-14
DLBC	Cell metabolism gene	TACO1	ECHS1	0.84639586	3.55E-14
DLBC	Cell metabolism gene	TACO1	SAT2	0.847622583	2.99E-14
DLBC	Cell metabolism gene	TACO1	POLE4	0.851544227	1.72E-14
DLBC	Cell metabolism gene	TACO1	DHRS4	0.853541032	1.29E-14
DLBC	Cell metabolism gene	TACO1	PSMD13	0.85441252	1.13E-14
DLBC	Cell metabolism gene	TACO1	PSMA7	0.85548094	9.67E-15
DLBC	Cell metabolism gene	TACO1	PHPT1	0.856723717	8.04E-15
DLBC	Cell metabolism gene	TACO1	PHKG2	0.859054125	5.66E-15
DLBC	Cell metabolism gene	TACO1	ITPA	0.859291736	5.46E-15
DLBC	Cell metabolism gene	TACO1	PSMC3	0.862122118	3.53E-15
DLBC	Cell metabolism gene	TACO1	TIMM13	0.864660679	2.37E-15
DLBC	Cell metabolism gene	TACO1	PSMB1	0.86494523	2.27E-15
DLBC	Cell metabolism gene	TACO1	PSMC5	0.869738356	1.04E-15
DLBC	Cell metabolism gene	TACO1	PSMB10	0.86987274	1.02E-15
DLBC	Cell metabolism gene	TACO1	MED27	0.870378422	9.37E-16
DLBC	Cell metabolism gene	TACO1	MTX1	0.870519557	9.15E-16
DLBC	Cell metabolism gene	TACO1	DPM2	0.873088567	5.94E-16
DLBC	Cell metabolism gene	TACO1	UROD	0.875856989	3.69E-16
DLBC	Cell metabolism gene	TACO1	PSMB4	0.882735961	1.07E-16
DLBC	Cell metabolism gene	TACO1	EXOSC4	0.904262108	1.28E-18
DLBC	Cell metabolism gene	TACO1	PSMD4	0.9069912	6.80E-19
DLBC	Cell metabolism gene	TACO1	PSMB6	0.926238064	4.06E-21
DLBC	Cell metabolism gene	TACO1	PSMB3	0.93380084	3.66E-22
DLBC	CGC	TACO1	SDHAF2	0.81135326	2.68E-12
DLBC	CGC	TACO1	ASPSCR1	0.836388612	1.35E-13
DLBC	CGC	TACO1	NTHL1	0.855781356	9.25E-15
DLBC	CGC	TACO1	TFPT	0.889870633	2.74E-17
DLBC	Epifactor	TACO1	RUVBL2	0.800775152	8.32E-12
DLBC	Epifactor	TACO1	PAF1	0.809207818	3.39E-12
DLBC	Epifactor	TACO1	ZGPAT	0.813967226	2.01E-12
DLBC	Epifactor	TACO1	DMAP1	0.81880039	1.16E-12
DLBC	Epifactor	TACO1	ZNHIT1	0.81986175	1.02E-12
DLBC	Epifactor	TACO1	C17orf49	0.820594165	9.40E-13
DLBC	Epifactor	TACO1	PRPF31	0.825261211	5.41E-13
DLBC	Epifactor	TACO1	BRMS1	0.836049442	1.41E-13
DLBC	Epifactor	TACO1	PPP4C	0.844472041	4.62E-14
DLBC	Epifactor	TACO1	RBX1	0.858270974	6.37E-15
DLBC	Epifactor	TACO1	MBD3	0.867779931	1.44E-15
DLBC	Epifactor	TACO1	SIRT6	0.881196294	1.42E-16
DLBC	Epifactor	TACO1	TFPT	0.889870633	2.74E-17
DLBC	Epifactor	TACO1	EXOSC4	0.904262108	1.28E-18
DLBC	IUPHAR	TACO1	PSMB5	0.808746021	3.57E-12
DLBC	IUPHAR	TACO1	TPRA1	0.810793413	2.85E-12
DLBC	IUPHAR	TACO1	SLC25A39	0.813397918	2.14E-12
DLBC	IUPHAR	TACO1	VKORC1	0.815294371	1.73E-12
DLBC	IUPHAR	TACO1	SLC25A26	0.815455881	1.70E-12
DLBC	IUPHAR	TACO1	PTGES2	0.816082477	1.58E-12
DLBC	IUPHAR	TACO1	MVD	0.816859091	1.45E-12
DLBC	IUPHAR	TACO1	SLC39A3	0.826192427	4.83E-13
DLBC	IUPHAR	TACO1	ATP6V1E1	0.84416194	4.82E-14
DLBC	IUPHAR	TACO1	PHKG2	0.859054125	5.66E-15
DLBC	IUPHAR	TACO1	MPDU1	0.863422698	2.88E-15
DLBC	IUPHAR	TACO1	PSMB1	0.86494523	2.27E-15
DLBC	IUPHAR	TACO1	SIRT6	0.881196294	1.42E-16
DLBC	IUPHAR	TACO1	PSMB6	0.926238064	4.06E-21
DLBC	Kinase	TACO1	PHKG2	0.859054125	5.66E-15
DLBC	TF	TACO1	DNTTIP1	0.809261786	3.37E-12
DLBC	TF	TACO1	ZGPAT	0.813967226	2.01E-12
DLBC	TF	TACO1	NME2	0.814194892	1.95E-12
DLBC	TF	TACO1	ZNF524	0.825926116	4.99E-13
DLBC	TF	TACO1	THAP7	0.835919451	1.44E-13
DLBC	TF	TACO1	IRF3	0.839123381	9.46E-14
DLBC	TF	TACO1	MBD3	0.867779931	1.44E-15
DLBC	TF	TACO1	PIN1	0.871152259	8.23E-16
DLBC	TF	TACO1	THAP3	0.871897413	7.27E-16
DLBC	TSG	TACO1	PARK7	0.802085342	7.26E-12
DLBC	TSG	TACO1	STUB1	0.803961091	5.96E-12
DLBC	TSG	TACO1	ARMC5	0.807231557	4.20E-12
DLBC	TSG	TACO1	DIABLO	0.830254121	2.94E-13
DLBC	TSG	TACO1	BRMS1	0.836049442	1.41E-13
DLBC	TSG	TACO1	IRF3	0.839123381	9.46E-14
DLBC	TSG	TACO1	PHB	0.850937187	1.87E-14
DLBC	TSG	TACO1	PIN1	0.871152259	8.23E-16
DLBC	TSG	TACO1	SIRT6	0.881196294	1.42E-16
DLBC	TSG	TACO1	TSSC4	0.897893324	5.26E-18
DLBC	TSG	TACO1	GADD45GIP1	0.912087059	1.97E-19
GBM	Cell metabolism gene	TACO1	NME1	0.801028414	9.94E-40
GBM	Cell metabolism gene	TACO1	NME2	0.807543008	7.92E-41
GBM	Cell metabolism gene	TACO1	PSMB3	0.828099975	1.37E-44
GBM	Cell metabolism gene	TACO1	ATP5G1	0.836243524	3.19E-46
GBM	TF	TACO1	NME2	0.807543008	7.92E-41
GBM	TSG	TACO1	NME1	0.801028414	9.94E-40
KIRP	Cell metabolism gene	TACO1	ATP5G1	0.812909873	2.35E-77
KIRP	TSG	TACO1	PHB	0.859339522	1.69E-95
LUAD	Cell metabolism gene	TACO1	NME1	0.805779848	1.04E-132
LUAD	TSG	TACO1	NME1	0.805779848	1.04E-132
MESO	Cell metabolism gene	TACO1	PSMC5	0.863858038	4.84E-27
MESO	TSG	TACO1	PHB	0.863198517	5.86E-27
PAAD	Cell metabolism gene	TACO1	PSMC5	0.853096775	5.03E-53
PRAD	Cell metabolism gene	TACO1	GFER	0.800103858	1.00E-123
PRAD	Cell metabolism gene	TACO1	POLR2I	0.805585198	1.12E-126
PRAD	Cell metabolism gene	TACO1	PSMB3	0.80593578	7.23E-127
PRAD	Cell metabolism gene	TACO1	PSMC5	0.821397629	9.67E-136
PRAD	TSG	TACO1	PHB	0.803324888	1.90E-125
PRAD	TSG	TACO1	GADD45GIP1	0.808585512	2.49E-128
TGCT	Cell metabolism gene	TACO1	PSMA7	0.801119713	3.72E-36
TGCT	Cell metabolism gene	TACO1	PSMD3	0.817931766	8.30E-39
TGCT	Cell metabolism gene	TACO1	PSMB6	0.82998548	6.97E-41
TGCT	IUPHAR	TACO1	PSMB6	0.82998548	6.97E-41
TGCT	IUPHAR	TACO1	SLC35B1	0.845046982	1.02E-43
TGCT	TSG	TACO1	PHB	0.817143034	1.12E-38
THYM	Cell metabolism gene	TACO1	MED19	0.800688347	1.80E-28
THYM	Cell metabolism gene	TACO1	TIMM17B	0.801211781	1.56E-28
THYM	Cell metabolism gene	TACO1	APRT	0.803150585	9.22E-29
THYM	Cell metabolism gene	TACO1	UROS	0.803151143	9.22E-29
THYM	Cell metabolism gene	TACO1	PGP	0.804788488	5.89E-29
THYM	Cell metabolism gene	TACO1	POLE4	0.805433188	4.93E-29
THYM	Cell metabolism gene	TACO1	LCMT1	0.806406196	3.76E-29
THYM	Cell metabolism gene	TACO1	PSMC1	0.806740572	3.43E-29
THYM	Cell metabolism gene	TACO1	PSMB4	0.807463883	2.80E-29
THYM	Cell metabolism gene	TACO1	CCT7	0.807723879	2.60E-29
THYM	Cell metabolism gene	TACO1	EBP	0.808994578	1.82E-29
THYM	Cell metabolism gene	TACO1	SNRPE	0.809166039	1.74E-29
THYM	Cell metabolism gene	TACO1	POLD2	0.811893824	7.98E-30
THYM	Cell metabolism gene	TACO1	DTYMK	0.811907482	7.95E-30
THYM	Cell metabolism gene	TACO1	PSMC3	0.812983745	5.83E-30
THYM	Cell metabolism gene	TACO1	PSMC4	0.816290926	2.22E-30
THYM	Cell metabolism gene	TACO1	ALG3	0.81696828	1.82E-30
THYM	Cell metabolism gene	TACO1	GEMIN6	0.818091564	1.30E-30
THYM	Cell metabolism gene	TACO1	PTGES2	0.819184219	9.40E-31
THYM	Cell metabolism gene	TACO1	FDPS	0.821983825	4.03E-31
THYM	Cell metabolism gene	TACO1	PSMB7	0.822091213	3.90E-31
THYM	Cell metabolism gene	TACO1	POLR2H	0.822933456	3.01E-31
THYM	Cell metabolism gene	TACO1	PIGU	0.82305986	2.90E-31
THYM	Cell metabolism gene	TACO1	SNRPD2	0.824000406	2.17E-31
THYM	Cell metabolism gene	TACO1	OAZ1	0.824295067	1.98E-31
THYM	Cell metabolism gene	TACO1	NANS	0.826436051	1.01E-31
THYM	Cell metabolism gene	TACO1	POLR2I	0.828741825	4.89E-32
THYM	Cell metabolism gene	TACO1	TIMM8B	0.828810927	4.79E-32
THYM	Cell metabolism gene	TACO1	PSMD8	0.830258502	3.01E-32
THYM	Cell metabolism gene	TACO1	MMAB	0.831827349	1.81E-32
THYM	Cell metabolism gene	TACO1	PYCRL	0.831996877	1.72E-32
THYM	Cell metabolism gene	TACO1	NME1	0.838962286	1.68E-33
THYM	Cell metabolism gene	TACO1	ACOT8	0.843194277	3.89E-34
THYM	Cell metabolism gene	TACO1	TOMM40	0.843413915	3.60E-34
THYM	Cell metabolism gene	TACO1	NME2	0.843815586	3.13E-34
THYM	Cell metabolism gene	TACO1	IDH3B	0.846120693	1.38E-34
THYM	Cell metabolism gene	TACO1	TPI1	0.846632775	1.15E-34
THYM	Cell metabolism gene	TACO1	TIMM10	0.848487067	5.85E-35
THYM	Cell metabolism gene	TACO1	DOHH	0.850266795	3.05E-35
THYM	Cell metabolism gene	TACO1	CYC1	0.851950271	1.63E-35
THYM	Cell metabolism gene	TACO1	PMPCA	0.851975259	1.61E-35
THYM	Cell metabolism gene	TACO1	TIMM13	0.853060727	1.07E-35
THYM	Cell metabolism gene	TACO1	TIMM50	0.855726353	3.89E-36
THYM	Cell metabolism gene	TACO1	PSMB3	0.861229818	4.48E-37
THYM	Cell metabolism gene	TACO1	COASY	0.868501886	2.22E-38
THYM	Cell metabolism gene	TACO1	HMOX2	0.870605816	9.00E-39
THYM	Cell metabolism gene	TACO1	PSMD4	0.871670801	5.67E-39
THYM	Cell metabolism gene	TACO1	MTX1	0.872765269	3.51E-39
THYM	Cell metabolism gene	TACO1	GEMIN7	0.873214309	2.88E-39
THYM	Cell metabolism gene	TACO1	EXOSC4	0.888110484	2.52E-42
THYM	Cell metabolism gene	TACO1	ATP5G1	0.903405693	5.94E-46
THYM	Cell metabolism gene	TACO1	PSMC5	0.912170566	2.57E-48
THYM	CGC	TACO1	NTHL1	0.810199147	1.30E-29
THYM	CGC	TACO1	PRCC	0.810523551	1.18E-29
THYM	CGC	TACO1	SDHAF2	0.82775091	6.70E-32
THYM	CGC	TACO1	ASPSCR1	0.840389686	1.03E-33
THYM	Epifactor	TACO1	SIRT6	0.804930897	5.66E-29
THYM	Epifactor	TACO1	RRP8	0.81056498	1.17E-29
THYM	Epifactor	TACO1	PRMT1	0.814540768	3.71E-30
THYM	Epifactor	TACO1	BRMS1	0.820666655	6.01E-31
THYM	Epifactor	TACO1	PRPF31	0.832177138	1.62E-32
THYM	Epifactor	TACO1	EXOSC4	0.888110484	2.52E-42
THYM	IUPHAR	TACO1	SIRT6	0.804930897	5.66E-29
THYM	IUPHAR	TACO1	PRMT1	0.814540768	3.71E-30
THYM	IUPHAR	TACO1	PTGES2	0.819184219	9.40E-31
THYM	IUPHAR	TACO1	USP5	0.820057234	7.23E-31
THYM	IUPHAR	TACO1	FDPS	0.821983825	4.03E-31
THYM	IUPHAR	TACO1	ATP6V0B	0.855659786	3.99E-36
THYM	IUPHAR	TACO1	HMOX2	0.870605816	9.00E-39
THYM	Kinase	TACO1	ADCK4	0.80430211	6.73E-29
THYM	TF	TACO1	ZNF787	0.81605296	2.38E-30
THYM	TF	TACO1	ZNF581	0.837294456	2.96E-33
THYM	TF	TACO1	NME2	0.843815586	3.13E-34
THYM	TSG	TACO1	SIRT6	0.804930897	5.66E-29
THYM	TSG	TACO1	DIABLO	0.808826109	1.91E-29
THYM	TSG	TACO1	BRMS1	0.820666655	6.01E-31
THYM	TSG	TACO1	GADD45GIP1	0.824557517	1.82E-31
THYM	TSG	TACO1	TSSC4	0.835225923	5.93E-33
THYM	TSG	TACO1	NME1	0.838962286	1.68E-33
THYM	TSG	TACO1	STUB1	0.85438271	6.50E-36
THYM	TSG	TACO1	PHB	0.912389963	2.23E-48
UCEC	Cell metabolism gene	TACO1	PSMC5	0.837444196	4.09E-54
UCEC	TSG	TACO1	PHB	0.808596656	1.01E-47
UCS	Cell metabolism gene	TACO1	MED19	0.800688347	1.80E-28
UCS	Cell metabolism gene	TACO1	TIMM17B	0.801211781	1.56E-28
UCS	Cell metabolism gene	TACO1	APRT	0.803150585	9.22E-29
UCS	Cell metabolism gene	TACO1	UROS	0.803151143	9.22E-29
UCS	Cell metabolism gene	TACO1	PGP	0.804788488	5.89E-29
UCS	Cell metabolism gene	TACO1	POLE4	0.805433188	4.93E-29
UCS	Cell metabolism gene	TACO1	LCMT1	0.806406196	3.76E-29
UCS	Cell metabolism gene	TACO1	PSMC1	0.806740572	3.43E-29
UCS	Cell metabolism gene	TACO1	PSMB4	0.807463883	2.80E-29
UCS	Cell metabolism gene	TACO1	CCT7	0.807723879	2.60E-29
UCS	Cell metabolism gene	TACO1	EBP	0.808994578	1.82E-29
UCS	Cell metabolism gene	TACO1	SNRPE	0.809166039	1.74E-29
UCS	Cell metabolism gene	TACO1	POLD2	0.811893824	7.98E-30
UCS	Cell metabolism gene	TACO1	DTYMK	0.811907482	7.95E-30
UCS	Cell metabolism gene	TACO1	PSMC3	0.812983745	5.83E-30
UCS	Cell metabolism gene	TACO1	PSMC4	0.816290926	2.22E-30
UCS	Cell metabolism gene	TACO1	ALG3	0.81696828	1.82E-30
UCS	Cell metabolism gene	TACO1	GEMIN6	0.818091564	1.30E-30
UCS	Cell metabolism gene	TACO1	PTGES2	0.819184219	9.40E-31
UCS	Cell metabolism gene	TACO1	FDPS	0.821983825	4.03E-31
UCS	Cell metabolism gene	TACO1	PSMB7	0.822091213	3.90E-31
UCS	Cell metabolism gene	TACO1	POLR2H	0.822933456	3.01E-31
UCS	Cell metabolism gene	TACO1	PIGU	0.82305986	2.90E-31
UCS	Cell metabolism gene	TACO1	SNRPD2	0.824000406	2.17E-31
UCS	Cell metabolism gene	TACO1	OAZ1	0.824295067	1.98E-31
UCS	Cell metabolism gene	TACO1	NANS	0.826436051	1.01E-31
UCS	Cell metabolism gene	TACO1	POLR2I	0.828741825	4.89E-32
UCS	Cell metabolism gene	TACO1	TIMM8B	0.828810927	4.79E-32
UCS	Cell metabolism gene	TACO1	PSMD8	0.830258502	3.01E-32
UCS	Cell metabolism gene	TACO1	MMAB	0.831827349	1.81E-32
UCS	Cell metabolism gene	TACO1	PYCRL	0.831996877	1.72E-32
UCS	Cell metabolism gene	TACO1	NME1	0.838962286	1.68E-33
UCS	Cell metabolism gene	TACO1	ACOT8	0.843194277	3.89E-34
UCS	Cell metabolism gene	TACO1	TOMM40	0.843413915	3.60E-34
UCS	Cell metabolism gene	TACO1	NME2	0.843815586	3.13E-34
UCS	Cell metabolism gene	TACO1	IDH3B	0.846120693	1.38E-34
UCS	Cell metabolism gene	TACO1	TPI1	0.846632775	1.15E-34
UCS	Cell metabolism gene	TACO1	TIMM10	0.848487067	5.85E-35
UCS	Cell metabolism gene	TACO1	DOHH	0.850266795	3.05E-35
UCS	Cell metabolism gene	TACO1	CYC1	0.851950271	1.63E-35
UCS	Cell metabolism gene	TACO1	PMPCA	0.851975259	1.61E-35
UCS	Cell metabolism gene	TACO1	TIMM13	0.853060727	1.07E-35
UCS	Cell metabolism gene	TACO1	TIMM50	0.855726353	3.89E-36
UCS	Cell metabolism gene	TACO1	PSMB3	0.861229818	4.48E-37
UCS	Cell metabolism gene	TACO1	COASY	0.868501886	2.22E-38
UCS	Cell metabolism gene	TACO1	HMOX2	0.870605816	9.00E-39
UCS	Cell metabolism gene	TACO1	PSMD4	0.871670801	5.67E-39
UCS	Cell metabolism gene	TACO1	MTX1	0.872765269	3.51E-39
UCS	Cell metabolism gene	TACO1	GEMIN7	0.873214309	2.88E-39
UCS	Cell metabolism gene	TACO1	EXOSC4	0.888110484	2.52E-42
UCS	Cell metabolism gene	TACO1	ATP5G1	0.903405693	5.94E-46
UCS	Cell metabolism gene	TACO1	PSMC5	0.912170566	2.57E-48
UCS	CGC	TACO1	NTHL1	0.810199147	1.30E-29
UCS	CGC	TACO1	PRCC	0.810523551	1.18E-29
UCS	CGC	TACO1	SDHAF2	0.82775091	6.70E-32
UCS	CGC	TACO1	ASPSCR1	0.840389686	1.03E-33
UCS	Epifactor	TACO1	SIRT6	0.804930897	5.66E-29
UCS	Epifactor	TACO1	RRP8	0.81056498	1.17E-29
UCS	Epifactor	TACO1	PRMT1	0.814540768	3.71E-30
UCS	Epifactor	TACO1	BRMS1	0.820666655	6.01E-31
UCS	Epifactor	TACO1	PRPF31	0.832177138	1.62E-32
UCS	Epifactor	TACO1	EXOSC4	0.888110484	2.52E-42
UCS	IUPHAR	TACO1	SIRT6	0.804930897	5.66E-29
UCS	IUPHAR	TACO1	PRMT1	0.814540768	3.71E-30
UCS	IUPHAR	TACO1	PTGES2	0.819184219	9.40E-31
UCS	IUPHAR	TACO1	USP5	0.820057234	7.23E-31
UCS	IUPHAR	TACO1	FDPS	0.821983825	4.03E-31
UCS	IUPHAR	TACO1	ATP6V0B	0.855659786	3.99E-36
UCS	IUPHAR	TACO1	HMOX2	0.870605816	9.00E-39
UCS	Kinase	TACO1	ADCK4	0.80430211	6.73E-29
UCS	TF	TACO1	ZNF787	0.81605296	2.38E-30
UCS	TF	TACO1	ZNF581	0.837294456	2.96E-33
UCS	TF	TACO1	NME2	0.843815586	3.13E-34
UCS	TSG	TACO1	SIRT6	0.804930897	5.66E-29
UCS	TSG	TACO1	DIABLO	0.808826109	1.91E-29
UCS	TSG	TACO1	BRMS1	0.820666655	6.01E-31
UCS	TSG	TACO1	GADD45GIP1	0.824557517	1.82E-31
UCS	TSG	TACO1	TSSC4	0.835225923	5.93E-33
UCS	TSG	TACO1	NME1	0.838962286	1.68E-33
UCS	TSG	TACO1	STUB1	0.85438271	6.50E-36
UCS	TSG	TACO1	PHB	0.912389963	2.23E-48
UVM	Cell metabolism gene	TACO1	GALK1	0.803931681	2.77E-19
UVM	CGC	TACO1	ASPSCR1	0.804760602	2.39E-19

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KICH	TACO1	TSFM	1.15779807454151	0.00129634141921997
BRCA	TACO1	LRPPRC	1.01301203198778	0.00135082071056631
COAD	TACO1	COX15	-2.5974345550705	0.00197160243988037
PRAD	TACO1	LRPPRC	-3.12366984674671	0.00361804803128602
HNSC	TACO1	YARS2	1.51758504797514	0.00498432417884942
ESCA	TACO1	YARS2	-2.00710684466974	0.0185546875
KIRP	TACO1	LRPPRC	-1.86182149887425	0.0216239951550961
UCEC	TACO1	CYCS	-2.81266000225107	0.03125
READ	TACO1	LRPPRC	1.69000859845838	0.03125
LUSC	TACO1	TSFM	-3.83005339359833	1.4433166414012e-09
LUAD	TACO1	LRPPRC	-2.88690888240574	2.06541148982154e-09
KIRC	TACO1	LRPPRC	-2.46850203122582	2.81176802000473e-08
BRCA	TACO1	TSFM	-2.93602416019673	2.90907687062967e-14
KICH	TACO1	CYCS	1.56563374350741	2.98023223876953e-07
THCA	TACO1	CYCS	1.97748704739574	3.03520282946109e-06
COAD	TACO1	COX10	-1.13387861194304	4.41074371337891e-05
BRCA	TACO1	CYCS	-1.49929042625543	4.88583064086618e-16
LUAD	TACO1	CYCS	-6.2492698502496	5.91982739853218e-07
LUAD	TACO1	COX10	-1.79457010216165	7.3663238952828e-06
LUAD	TACO1	TSFM	-4.00047669194892	9.20176185683847e-09

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with TACO1

SAT1, APP, SLC9A3R2, HPDL, SEC22B, GAPDH, CAB39, FOXD4, AIFM1, MRM1, HSPD1, PDK1, COX14, SFXN1, TRMT61B, AURKAIP1, TRIM28, LNX1, KRT31, PPP1R16B, MDFI, TRIM23, KRT34, MTUS2, RINT1, CALCOCO2, CIB4, GOLGA6L9, TRIM27, KRT40, PLEKHA4, M, ORF8b, PARL, IMMP1L, IMMP2L, ERCC6, HSCB, GRSF1, Arhgap1, ARHGAP26, Arhgap30, ACAD9, AUH, C12orf65, C17orf80, C1QBP, C21orf33, C6orf203, C8orf82, MCUR1, CCDC90B, CHCHD1, COX15, CRYZ, CS, DDX28, DHX30, FASTKD2, FASTKD3, FASTKD5, GFM1, GFM2, HINT2, ICT1, LONP1, LRPPRC, MCU, CCDC109B, MDH2, METTL15, METTL17, MRPL11, MRPS12, MRPS26, MRRF, MTERF3, MTFMT, MTG1, MTG2, MTIF2, MTIF3, MTRF1, MTRF1L, NGRN, OTC, PMPCA, PMPCB, RMND1, RPUSD3, RPUSD4, SLIRP, SSBP1, SURF1, ABCB7, ACAT1, ACOT1, ACOT2, AFG3L2, AK4, ALAS1, ALDH4A1, ALYREF, ATP5B, ATP5J2-PTCD1, ATP5L, ATP5F1, ATP5H, ATP5J, ATP5O, ATPAF1, BCS1L, CARS2, CLPX, COX4I1, COX5A, DAP3, DBT, DLAT, DLST, EARS2, ECHS1, ECSIT, ELAC2, ERAL1, ETFA, ETFB, GADD45GIP1, GATB, GATC, GCDH, GLS, GLUD1, GTPBP10, GUF1, HNRNPAB, HNRNPDL, HNRNPL, HNRNPUL1, HSD17B10, HSDL2, IARS2, IBA57, ITPR3, KIAA0391, LARS2, LETM1, LYRM4, MMAB, RNMTL1, MRPL1, MRPL10, MRPL12, MRPL13, MRPL15, MRPL16, MRPL17, MRPL18, MRPL19, MRPL2, MRPL20, MRPL21, MRPL22, MRPL23, MRPL24, MRPL27, MRPL28, MRPL3, MRPL37, MRPL38, MRPL39, MRPL4, MRPL40, MRPL41, MRPL42, MRPL43, MRPL44, MRPL45, MRPL46, MRPL47, MRPL48, MRPL49, MRPL50, MRPL51, MRPL52, MRPL53, MRPL55, MRPL9, MRPS10, MRPS11, MRPS14, MRPS16, MRPS17, MRPS18A, MRPS18B, MRPS18C, MRPS2, MRPS22, MRPS23, MRPS24, MRPS25, MRPS27, MRPS28, MRPS30, MRPS31, MRPS33, MRPS34, MRPS35, MRPS36, MRPS5, MRPS6, MRPS7, MRPS9, NDUFA12, NDUFA2, NDUFA5, NDUFA6, NDUFA7, NDUFA9, NDUFAB1, NDUFAF1, NDUFAF2, NDUFAF3, NDUFAF4, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, NFS1, NIPSNAP1, NME4, NT5DC2, OAT, OGDH, OXA1L, PAM16, PDE12, PDHA1, PDHB, PDHX, PDK3, PDPR, PHB, PNPT1, POLDIP2, POLG, POLRMT, PPIF, PTCD3, PYCR1, PYCR2, QRSL1, RBMX, RTN4IP1, SHMT2, SLC30A9, STOML2, SUCLA2, THG1L, TIMM44, TM9SF3, TRMT10C, TRUB2, TSFM, C10orf2, VARS2, VWA8, TBRG4, TEFM, TFAM, C19orf52, TMEM70, TUFM, EXD2, CLPP, INS, BKRF1, DNAJC15, DNAJC19, DNAJC28, LRPAP1, PIP4K2A, PRPF38A, LYAR, CTTN, CSNK1E, TMA16, RPS21, PRPF3, NSRP1, C1orf35, PPP1R10, PRPF38B, TCEB3, PHF6, MECP2, PDIA6, YY1, CKAP4, CCNT1, RRP1B, DDX42, PRPF4, DDX56, C9orf114, TOX4, HOXA5, MFAP1, KNOP1, SLTM, SF3B4, ATPIF1, TAF2, PPIL4, RBM25, PHF3, CPSF7, AARS2, COX8A, TRAP1, HTRA4, WDR5,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
TACO1	chr17	61678266	C	T	single_nucleotide_variant	Uncertain_significance	Mitochondrial_complex_IV_deficiency	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
TACO1	chr17	61678275	A	G	single_nucleotide_variant	Uncertain_significance	Mitochondrial_complex_IV_deficiency	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
TACO1	chr17	61678280	A	G	single_nucleotide_variant	Uncertain_significance	Mitochondrial_complex_IV_deficiency	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
TACO1	chr17	61678469	A	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
TACO1	chr17	61678508	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
TACO1	chr17	61678534	A	AC	Duplication	Pathogenic	Mitochondrial_complex_IV_deficiency	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
TACO1	chr17	61678534	AC	A	Deletion	Likely_pathogenic	not_provided	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
TACO1	chr17	61678540	G	A	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TACO1	chr17	61678646	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
TACO1	chr17	61678654	G	C	single_nucleotide_variant	Uncertain_significance	Mitochondrial_complex_IV_deficiency	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TACO1	chr17	61678661	G	A	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	Mitochondrial_complex_IV_deficiency\|not_specified\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
TACO1	chr17	61678691	ACT	A	Microsatellite	Likely_pathogenic	not_provided	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
TACO1	chr17	61678703	C	T	single_nucleotide_variant	Uncertain_significance	Mitochondrial_complex_IV_deficiency	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
TACO1	chr17	61678764	T	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TACO1	chr17	61678953	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TACO1	chr17	61678980	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TACO1	chr17	61681717	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TACO1	chr17	61681849	A	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TACO1	chr17	61681881	CT	C	Deletion	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TACO1	chr17	61681910	T	G	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	Mitochondrial_complex_IV_deficiency\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
TACO1	chr17	61681940	A	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
TACO1	chr17	61682080	A	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TACO1	chr17	61683490	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TACO1	chr17	61683706	C	T	single_nucleotide_variant	Pathogenic	Mitochondrial_complex_4_deficiency,_nuclear_type_8	SO:0001587\|nonsense	SO:0001587\|nonsense
TACO1	chr17	61683718	G	A	single_nucleotide_variant	Benign	Mitochondrial_complex_IV_deficiency\|not_specified\|not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TACO1	chr17	61683755	G	GC	Duplication	Likely_pathogenic	Mitochondrial_complex_IV_deficiency\|Mitochondrial_complex_4_deficiency,_nuclear_type_8	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
TACO1	chr17	61683761	A	G	single_nucleotide_variant	Uncertain_significance	Mitochondrial_complex_IV_deficiency	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TACO1	chr17	61683783	T	C	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	Mitochondrial_complex_IV_deficiency\|not_specified\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
TACO1	chr17	61683796	A	C	single_nucleotide_variant	Uncertain_significance	Mitochondrial_complex_IV_deficiency	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TACO1	chr17	61683811	G	A	single_nucleotide_variant	Uncertain_significance	Mitochondrial_complex_IV_deficiency	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TACO1	chr17	61683851	A	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TACO1	chr17	61684515	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TACO1	chr17	61684557	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TACO1	chr17	61684629	T	A	single_nucleotide_variant	Benign	not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TACO1	chr17	61684669	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TACO1	chr17	61684712	AG	A	Deletion	Likely_pathogenic	Mitochondrial_complex_IV_deficiency	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
TACO1	chr17	61684740	A	C	single_nucleotide_variant	Likely_benign	not_specified	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
TACO1	chr17	61684745	G	A	single_nucleotide_variant	Likely_benign	not_specified	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TACO1	chr17	61684749	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
TACO1	chr17	61684751	T	C	single_nucleotide_variant	Likely_pathogenic	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TACO1	chr17	61684769	C	A	single_nucleotide_variant	Uncertain_significance	Mitochondrial_complex_IV_deficiency	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TACO1	chr17	61684781	A	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TACO1	chr17	61684884	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
TACO1	chr17	61685210	T	G	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	Mitochondrial_complex_IV_deficiency\|not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TACO1	chr17	61685233	C	G	single_nucleotide_variant	Uncertain_significance	Mitochondrial_complex_IV_deficiency	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
TACO1	chr17	61685287	G	A	single_nucleotide_variant	Likely_benign	not_specified\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
TACO1	chr17	61685341	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
TACO1	chr17	61685342	G	A	single_nucleotide_variant	Uncertain_significance	Mitochondrial_complex_IV_deficiency	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TACO1	chr17	61685353	C	T	single_nucleotide_variant	Likely_benign	not_specified	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
TACO1	chr17	61685355	T	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
TACO1	chr17	61685381	C	T	single_nucleotide_variant	Benign	not_specified	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
TACO1	chr17	61685391	C	T	single_nucleotide_variant	Uncertain_significance	Mitochondrial_complex_IV_deficiency	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
TACO1	chr17	61685406	G	T	single_nucleotide_variant	Uncertain_significance	Mitochondrial_complex_IV_deficiency	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
TACO1	chr17	61685592	G	A	single_nucleotide_variant	Uncertain_significance	Mitochondrial_complex_IV_deficiency	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
TACO1	chr17	61685613	A	G	single_nucleotide_variant	Uncertain_significance	Mitochondrial_complex_IV_deficiency	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
TACO1	chr17	61685632	TTGGGTAGCTGGCCTCTG	T	Deletion	Benign	not_provided	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
TACO1	chr17	61685705	C	T	single_nucleotide_variant	Likely_benign	Mitochondrial_complex_IV_deficiency	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
TACO1	ESCA	chr17	61681893	61681893	G	A	Splice_Site		4
TACO1	BRCA	chr17	61684785	61684785	C	T	Silent	p.V218	4
TACO1	ESCA	chr17	61683700	61683700	G	A	Missense_Mutation	p.E139K	3
TACO1	BLCA	chr17	61678640	61678640	C	T	Silent	p.V66V	2
TACO1	ESCA	chr17	61683719	61683719	G	A	Missense_Mutation	p.G145D	2
TACO1	UCEC	chr17	61684783	61684783	G	A	Missense_Mutation	p.V218I	2
TACO1	SKCM	chr17	61685212	61685212	C	T	Silent	p.S248S	2
TACO1	UCEC	chr17	61685164	61685164	T	G	Missense_Mutation	p.F232L	2
TACO1	SKCM	chr17	61685284	61685284	C	T	Silent	p.D272D	2
TACO1	ESCA	chr17	61683700	61683700	G	A	Missense_Mutation		2
TACO1	SKCM	chr17	61685285	61685285	C	T	Silent	p.L273L	2
TACO1	CESC	chr17	61685348	61685348	G	A	Missense_Mutation		2
TACO1	STAD	chr17	61684818	61684818	T	G	Silent	p.V229V	2
TACO1	CESC	chr17	61683707	61683707	G	A	Missense_Mutation		2
TACO1	STAD	chr17	61685281	61685281	C	T	Silent	p.P271P	2
TACO1	CESC	chr17	61685348	61685348	G	A	Missense_Mutation	p.D294N	2
TACO1	BLCA	chr17	61678658	61678658	G	A	Silent		1
TACO1	STAD	chr17	61681964	61681964	G	A	Missense_Mutation	p.M117I	1
TACO1	ESCA	chr17	61681893	61681893	G	A	Splice_Site	e2-1	1
TACO1	LUAD	chr17	61683704	61683704	G	A	Missense_Mutation	p.G140D	1
TACO1	BLCA	chr17	61685197	61685197	G	A	Silent	p.R243R	1
TACO1	THYM	chr17	61678608	61678608	G	T	Missense_Mutation	p.V56F	1
TACO1	MESO	chr17	61685206	61685206	G	T	Silent		1
TACO1	UCEC	chr17	61683764	61683764	G	T	Missense_Mutation	p.C160F	1
TACO1	SARC	chr17	61685174	61685174	G	T	Missense_Mutation		1
TACO1	BLCA	chr17	61684690	61684690	G	C	Missense_Mutation	p.G187R	1
TACO1	ESCA	chr17	61683719	61683719	G	A	Missense_Mutation		1
TACO1	BLCA	chr17	61684733	61684733	T	C	Missense_Mutation	p.V201A	1
TACO1	BLCA	chr17	61678658	61678658	G	A	Silent	p.P72P	1
TACO1	ESCA	chr17	61678568	61678568	C	T	Silent	p.C42C	1
TACO1	BLCA	chr17	61685197	61685197	G	A	Silent		1
TACO1	SKCM	chr17	61685219	61685219	C	A	Missense_Mutation	p.L251M	1
TACO1	LIHC	chr17	61678596	61678596	T	C	Missense_Mutation	p.F52L	1
TACO1	BLCA	chr17	61678640	61678640	C	T	Silent		1
TACO1	LIHC	chr17	61681900	61681901	-	C	Frame_Shift_Ins	p.A96fs	1
TACO1	BLCA	chr17	61684690	61684690	G	C	Missense_Mutation		1
TACO1	LIHC	chr17	61685307	61685307	T	-	Frame_Shift_Del	p.I280fs	1
TACO1	BLCA	chr17	61684733	61684733	T	C	Missense_Mutation		1
TACO1	STAD	chr17	61685311	61685311	G	A	Silent	p.Q281Q	1
TACO1	CESC	chr17	61684681	61684681	G	G	Missense_Mutation		1
TACO1	LIHC	chr17	61681907	61681907	C	-	Frame_Shift_Del	p.N98fs	1

Copy number variation (CNV) of TACO1
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across TACO1
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
51311	LGG	TCGA-FG-A87Q-01A	BCAS3	chr17	59161925	+	TACO1	chr17	61681894	+
51313	OV	TCGA-25-1870-01A	MAP3K3	chr17	61700123	+	TACO1	chr17	61673322	+
51313	OV	TCGA-25-1870-01A	MAP3K3	chr17	61700123	+	TACO1	chr17	61681894	+
88676	N/A	AA447355	TACO1	chr17	61683681	+	NMT2	chr10	15196040	-
88676	N/A	AF090929	TACO1	chr17	61685725	+	RP11-289H16.1	chr1	91718974	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
BRCA	TACO1	0.00059020803002978	0.017
HNSC	TACO1	0.0138375940606601	0.37
KIRP	TACO1	0.0429675862410542	1

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LIHC	TACO1	0.0121284884213392	0.36
LUSC	TACO1	2.84162885143888e-05	0.00094
THCA	TACO1	0.000156895099542379	0.005
LGG	TACO1	0.00330450462197778	0.1
BLCA	TACO1	0.0485063638037393	1
SARC	TACO1	0.0172267354439934	0.5

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0023264	Leigh Disease	3	CLINGEN;CTD_human;GENOMICS_ENGLAND
C0268237	Cytochrome-c Oxidase Deficiency	3	CTD_human;GENOMICS_ENGLAND
C1838951	LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX I DEFICIENCY	3	CLINGEN
C1850597	Leigh Syndrome Due To Mitochondrial Complex II Deficiency	3	CLINGEN
C1850598	Leigh Syndrome due to Mitochondrial Complex III Deficiency	3	CLINGEN
C1850599	Leigh Syndrome due to Mitochondrial Complex IV Deficiency	3	CLINGEN;GENOMICS_ENGLAND
C1850600	Leigh Syndrome due to Mitochondrial Complex V Deficiency	3	CLINGEN
C2931891	Necrotizing encephalopathy, infantile subacute, of Leigh	3	CLINGEN
C0751267	Encephalopathy, Subacute Necrotizing, Infantile	1	CTD_human
C0751268	Encephalopathy, Subacute Necrotizing, Juvenile	1	CTD_human