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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: MRPL37 (NCBI Gene ID:51253)

Gene Summary

Gene Summary

Gene Information	Gene Name: MRPL37
	Gene ID: 51253
	Gene Symbol	MRPL37
	Gene ID	51253
	Gene Name	mitochondrial ribosomal protein L37
	Synonyms	L2mt\|L37mt\|MRP-L2\|MRP-L37\|MRPL2\|RPML2
	Cytomap	1p32.3
	Type of Gene	protein-coding
	Description	39S ribosomal protein L37, mitochondrial39S ribosomal protein L2, mitochondrialmitochondrial large ribosomal subunit protein mL37ribosomal protein, mitochondrial, L2
	Modification date	20200313
	UniProtAcc	Q9BZE1

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
MRPL37	(733 - 1119.25]

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Translation Studies in PubMed

We searched PubMed using 'MRPL37[title] AND translation [title] AND human.'

Gene	Title	PMID
MRPL37	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000360840	54675618	54675804	In-frame
ENST00000360840	54678173	54678331	Frame-shift

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000360840	54675618	54675804	1495	724	909	423	215	277

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
Q9BZE1	215	277	30	423	Chain	ID=PRO_0000045905;Note=39S ribosomal protein L37%2C mitochondrial
Q9BZE1	215	277	206	215	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5OOM
Q9BZE1	215	277	218	227	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5OOM
Q9BZE1	215	277	229	234	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5OOM
Q9BZE1	215	277	242	247	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5OOM
Q9BZE1	215	277	257	259	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5OOM
Q9BZE1	215	277	261	264	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5OOM
Q9BZE1	215	277	265	270	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5OOM

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
PRAD	MRPL37	-2.21074342735295	3.65283830814974e-07
LUAD	MRPL37	-2.86549200993971	3.76287422734829e-10
BRCA	MRPL37	-3.79079551418026	9.33185484212232e-10

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
ACC	MRPL37	2	3	0.0391277037809908	0.545122413793103	0.623586083743842	-0.524172732974715	-0.171455425282662
THCA	MRPL37	2	3	0.0357039710942925	0.578422514204545	0.614301861702128	-0.0636377169495382	0.0220264896107519
THYM	MRPL37	2	3	0.0105451274750194	0.553616552315609	0.633958219178082	0.874395989812587	1.16520519115704

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
OV	MRPL37	0.047579356	0.019559902
ESCA	MRPL37	0.067451696	0.023265376
MESO	MRPL37	0.074314052	0.02590112

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with MRPL37 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	Cell metabolism gene	MRPL37	UROD	0.809947847	1.60E-11
DLBC	Cell metabolism gene	MRPL37	TIMM10	0.804891524	5.40E-12
DLBC	Cell metabolism gene	MRPL37	PSMA5	0.809783735	3.19E-12
DLBC	Cell metabolism gene	MRPL37	PSMB7	0.810776229	2.86E-12
DLBC	Cell metabolism gene	MRPL37	TOMM22	0.810929692	2.81E-12
DLBC	Cell metabolism gene	MRPL37	DTYMK	0.81096114	2.80E-12
DLBC	Cell metabolism gene	MRPL37	POLR2L	0.813386103	2.14E-12
DLBC	Cell metabolism gene	MRPL37	PSMD8	0.820060291	1.00E-12
DLBC	Cell metabolism gene	MRPL37	TPI1	0.822814436	7.24E-13
DLBC	Cell metabolism gene	MRPL37	SNRPB	0.823011751	7.07E-13
DLBC	Cell metabolism gene	MRPL37	PSMA4	0.826317212	4.76E-13
DLBC	Cell metabolism gene	MRPL37	IDH3B	0.832332839	2.27E-13
DLBC	Cell metabolism gene	MRPL37	FPGS	0.833329534	2.00E-13
DLBC	Cell metabolism gene	MRPL37	PSMC3	0.841345016	7.05E-14
DLBC	Cell metabolism gene	MRPL37	SNRPD2	0.843317137	5.41E-14
DLBC	Cell metabolism gene	MRPL37	TIMM13	0.849805033	2.20E-14
DLBC	Cell metabolism gene	MRPL37	SNRPD3	0.854649021	1.09E-14
DLBC	Cell metabolism gene	MRPL37	SAMM50	0.863506449	2.85E-15
DLBC	Cell metabolism gene	MRPL37	TIMM50	0.872827253	6.21E-16
DLBC	Cell metabolism gene	MRPL37	AK2	0.874632241	4.56E-16
DLBC	Epifactor	MRPL37	FBL	0.853018201	1.39E-14
DLBC	IUPHAR	MRPL37	BIRC5	0.810249302	3.03E-12
DLBC	IUPHAR	MRPL37	MFSD2B	0.822240836	7.75E-13
LGG	Cell metabolism gene	MRPL37	PSMB2	0.812117604	1.25E-125
LGG	Cell metabolism gene	MRPL37	PSMA5	0.82052076	2.38E-130
LGG	IUPHAR	MRPL37	PSMB2	0.812117604	1.25E-125
TGCT	Cell metabolism gene	MRPL37	ENO1	0.800258779	5.01E-36
TGCT	Cell metabolism gene	MRPL37	MDH2	0.802935095	1.98E-36
TGCT	Cell metabolism gene	MRPL37	SLC25A5	0.809300794	2.06E-37
TGCT	Cell metabolism gene	MRPL37	PSMB2	0.832317229	2.65E-41
TGCT	Cell metabolism gene	MRPL37	PSMA5	0.834386402	1.11E-41
TGCT	CGC	MRPL37	HMGA1	0.804845939	1.01E-36
TGCT	IUPHAR	MRPL37	SLC25A5	0.809300794	2.06E-37
TGCT	IUPHAR	MRPL37	PSMB2	0.832317229	2.65E-41
TGCT	TF	MRPL37	HMGA1	0.804845939	1.01E-36
TGCT	TF	MRPL37	CHCHD3	0.811424803	9.48E-38
THYM	Cell metabolism gene	MRPL37	IMPDH2	0.801376476	1.49E-28
THYM	Cell metabolism gene	MRPL37	HSD17B10	0.802446394	1.12E-28
THYM	Cell metabolism gene	MRPL37	SNRPB	0.802926738	9.80E-29
THYM	Cell metabolism gene	MRPL37	POLE4	0.804004935	7.30E-29
THYM	Cell metabolism gene	MRPL37	PSMD13	0.804604937	6.19E-29
THYM	Cell metabolism gene	MRPL37	TIMM10	0.80591751	4.31E-29
THYM	Cell metabolism gene	MRPL37	PSMA5	0.806395596	3.77E-29
THYM	Cell metabolism gene	MRPL37	FPGS	0.807059466	3.14E-29
THYM	Cell metabolism gene	MRPL37	DOHH	0.808835065	1.91E-29
THYM	Cell metabolism gene	MRPL37	NME1	0.811170035	9.82E-30
THYM	Cell metabolism gene	MRPL37	TOMM40	0.811356098	9.32E-30
THYM	Cell metabolism gene	MRPL37	CYC1	0.811846202	8.09E-30
THYM	Cell metabolism gene	MRPL37	OAZ1	0.813429002	5.13E-30
THYM	Cell metabolism gene	MRPL37	PSMD4	0.81374978	4.67E-30
THYM	Cell metabolism gene	MRPL37	ATP5G1	0.815373989	2.91E-30
THYM	Cell metabolism gene	MRPL37	PSMC5	0.817652306	1.49E-30
THYM	Cell metabolism gene	MRPL37	TOMM22	0.819365855	8.90E-31
THYM	Cell metabolism gene	MRPL37	TIMM8B	0.821989078	4.02E-31
THYM	Cell metabolism gene	MRPL37	SLC27A5	0.822585792	3.35E-31
THYM	Cell metabolism gene	MRPL37	PTGES2	0.82415891	2.06E-31
THYM	Cell metabolism gene	MRPL37	POLR2H	0.824399133	1.92E-31
THYM	Cell metabolism gene	MRPL37	EXOSC5	0.824989314	1.60E-31
THYM	Cell metabolism gene	MRPL37	ACOT8	0.826255943	1.07E-31
THYM	Cell metabolism gene	MRPL37	ITPA	0.827073845	8.30E-32
THYM	Cell metabolism gene	MRPL37	TIMM50	0.827145576	8.12E-32
THYM	Cell metabolism gene	MRPL37	PSMB3	0.827188072	8.01E-32
THYM	Cell metabolism gene	MRPL37	GEMIN7	0.829945261	3.33E-32
THYM	Cell metabolism gene	MRPL37	FDPS	0.83042978	2.85E-32
THYM	Cell metabolism gene	MRPL37	NANS	0.831918122	1.76E-32
THYM	Cell metabolism gene	MRPL37	TALDO1	0.835202436	5.97E-33
THYM	Cell metabolism gene	MRPL37	PSMA7	0.837398952	2.86E-33
THYM	Cell metabolism gene	MRPL37	POLR2E	0.838866744	1.74E-33
THYM	Cell metabolism gene	MRPL37	HMBS	0.839368032	1.47E-33
THYM	Cell metabolism gene	MRPL37	SNRPE	0.840297115	1.07E-33
THYM	Cell metabolism gene	MRPL37	PSMB2	0.840979647	8.42E-34
THYM	Cell metabolism gene	MRPL37	PSMB7	0.841359006	7.38E-34
THYM	Cell metabolism gene	MRPL37	HMOX2	0.842227748	5.46E-34
THYM	Cell metabolism gene	MRPL37	MED19	0.84368401	3.28E-34
THYM	Cell metabolism gene	MRPL37	MDH2	0.844187623	2.74E-34
THYM	Cell metabolism gene	MRPL37	SNRPD2	0.847292363	9.03E-35
THYM	Cell metabolism gene	MRPL37	NOP56	0.855905951	3.63E-36
THYM	Cell metabolism gene	MRPL37	PSMC3	0.859606213	8.55E-37
THYM	Cell metabolism gene	MRPL37	PSMD8	0.863560275	1.74E-37
THYM	Cell metabolism gene	MRPL37	PMPCA	0.871847799	5.24E-39
THYM	Cell metabolism gene	MRPL37	DTYMK	0.876447237	6.74E-40
THYM	Cell metabolism gene	MRPL37	EXOSC4	0.879052486	2.03E-40
THYM	Cell metabolism gene	MRPL37	IDH3B	0.888042455	2.61E-42
THYM	Cell metabolism gene	MRPL37	CCT7	0.893270574	1.74E-43
THYM	Cell metabolism gene	MRPL37	TIMM13	0.894377992	9.60E-44
THYM	Cell metabolism gene	MRPL37	POLD2	0.895227767	6.07E-44
THYM	CGC	MRPL37	PRCC	0.804056522	7.20E-29
THYM	CGC	MRPL37	CDK4	0.809898738	1.41E-29
THYM	CGC	MRPL37	TFPT	0.813684985	4.76E-30
THYM	CGC	MRPL37	SDHAF2	0.848794551	5.23E-35
THYM	Epifactor	MRPL37	LAS1L	0.803545568	8.28E-29
THYM	Epifactor	MRPL37	C17orf49	0.80398515	7.34E-29
THYM	Epifactor	MRPL37	PPP4C	0.805452271	4.90E-29
THYM	Epifactor	MRPL37	MBD3	0.807362323	2.88E-29
THYM	Epifactor	MRPL37	TFPT	0.813684985	4.76E-30
THYM	Epifactor	MRPL37	RUVBL2	0.818817694	1.05E-30
THYM	Epifactor	MRPL37	BRMS1	0.823240772	2.74E-31
THYM	Epifactor	MRPL37	EXOSC5	0.824989314	1.60E-31
THYM	Epifactor	MRPL37	NOC2L	0.835221049	5.94E-33
THYM	Epifactor	MRPL37	PRPF31	0.849632894	3.85E-35
THYM	Epifactor	MRPL37	RRP8	0.859132645	1.03E-36
THYM	Epifactor	MRPL37	FBL	0.878857155	2.23E-40
THYM	Epifactor	MRPL37	EXOSC4	0.879052486	2.03E-40
THYM	Epifactor	MRPL37	PRMT1	0.887048933	4.29E-42
THYM	IUPHAR	MRPL37	ECE2	0.801279195	1.53E-28
THYM	IUPHAR	MRPL37	IMPDH2	0.801376476	1.49E-28
THYM	IUPHAR	MRPL37	ATP6V0B	0.808697645	1.98E-29
THYM	IUPHAR	MRPL37	CDK4	0.809898738	1.41E-29
THYM	IUPHAR	MRPL37	SLC27A5	0.822585792	3.35E-31
THYM	IUPHAR	MRPL37	PTGES2	0.82415891	2.06E-31
THYM	IUPHAR	MRPL37	FDPS	0.83042978	2.85E-32
THYM	IUPHAR	MRPL37	EGLN2	0.832018438	1.70E-32
THYM	IUPHAR	MRPL37	USP5	0.834416563	7.75E-33
THYM	IUPHAR	MRPL37	PSMB2	0.840979647	8.42E-34
THYM	IUPHAR	MRPL37	HMOX2	0.842227748	5.46E-34
THYM	IUPHAR	MRPL37	PRMT1	0.887048933	4.29E-42
THYM	Kinase	MRPL37	CDK4	0.809898738	1.41E-29
THYM	Kinase	MRPL37	ADCK4	0.815168728	3.09E-30
THYM	TF	MRPL37	ZNF787	0.805203589	5.25E-29
THYM	TF	MRPL37	MBD3	0.807362323	2.88E-29
THYM	TF	MRPL37	REXO4	0.828506044	5.28E-32
THYM	TF	MRPL37	ZNF581	0.869419563	1.50E-38
THYM	TSG	MRPL37	NME1	0.811170035	9.82E-30
THYM	TSG	MRPL37	BRMS1	0.823240772	2.74E-31
THYM	TSG	MRPL37	STUB1	0.826538925	9.83E-32
THYM	TSG	MRPL37	TSSC4	0.866408449	5.37E-38
THYM	TSG	MRPL37	PHB	0.876973383	5.31E-40
UCS	Cell metabolism gene	MRPL37	IMPDH2	0.801376476	1.49E-28
UCS	Cell metabolism gene	MRPL37	HSD17B10	0.802446394	1.12E-28
UCS	Cell metabolism gene	MRPL37	SNRPB	0.802926738	9.80E-29
UCS	Cell metabolism gene	MRPL37	POLE4	0.804004935	7.30E-29
UCS	Cell metabolism gene	MRPL37	PSMD13	0.804604937	6.19E-29
UCS	Cell metabolism gene	MRPL37	TIMM10	0.80591751	4.31E-29
UCS	Cell metabolism gene	MRPL37	PSMA5	0.806395596	3.77E-29
UCS	Cell metabolism gene	MRPL37	FPGS	0.807059466	3.14E-29
UCS	Cell metabolism gene	MRPL37	DOHH	0.808835065	1.91E-29
UCS	Cell metabolism gene	MRPL37	NME1	0.811170035	9.82E-30
UCS	Cell metabolism gene	MRPL37	TOMM40	0.811356098	9.32E-30
UCS	Cell metabolism gene	MRPL37	CYC1	0.811846202	8.09E-30
UCS	Cell metabolism gene	MRPL37	OAZ1	0.813429002	5.13E-30
UCS	Cell metabolism gene	MRPL37	PSMD4	0.81374978	4.67E-30
UCS	Cell metabolism gene	MRPL37	ATP5G1	0.815373989	2.91E-30
UCS	Cell metabolism gene	MRPL37	PSMC5	0.817652306	1.49E-30
UCS	Cell metabolism gene	MRPL37	TOMM22	0.819365855	8.90E-31
UCS	Cell metabolism gene	MRPL37	TIMM8B	0.821989078	4.02E-31
UCS	Cell metabolism gene	MRPL37	SLC27A5	0.822585792	3.35E-31
UCS	Cell metabolism gene	MRPL37	PTGES2	0.82415891	2.06E-31
UCS	Cell metabolism gene	MRPL37	POLR2H	0.824399133	1.92E-31
UCS	Cell metabolism gene	MRPL37	EXOSC5	0.824989314	1.60E-31
UCS	Cell metabolism gene	MRPL37	ACOT8	0.826255943	1.07E-31
UCS	Cell metabolism gene	MRPL37	ITPA	0.827073845	8.30E-32
UCS	Cell metabolism gene	MRPL37	TIMM50	0.827145576	8.12E-32
UCS	Cell metabolism gene	MRPL37	PSMB3	0.827188072	8.01E-32
UCS	Cell metabolism gene	MRPL37	GEMIN7	0.829945261	3.33E-32
UCS	Cell metabolism gene	MRPL37	FDPS	0.83042978	2.85E-32
UCS	Cell metabolism gene	MRPL37	NANS	0.831918122	1.76E-32
UCS	Cell metabolism gene	MRPL37	TALDO1	0.835202436	5.97E-33
UCS	Cell metabolism gene	MRPL37	PSMA7	0.837398952	2.86E-33
UCS	Cell metabolism gene	MRPL37	POLR2E	0.838866744	1.74E-33
UCS	Cell metabolism gene	MRPL37	HMBS	0.839368032	1.47E-33
UCS	Cell metabolism gene	MRPL37	SNRPE	0.840297115	1.07E-33
UCS	Cell metabolism gene	MRPL37	PSMB2	0.840979647	8.42E-34
UCS	Cell metabolism gene	MRPL37	PSMB7	0.841359006	7.38E-34
UCS	Cell metabolism gene	MRPL37	HMOX2	0.842227748	5.46E-34
UCS	Cell metabolism gene	MRPL37	MED19	0.84368401	3.28E-34
UCS	Cell metabolism gene	MRPL37	MDH2	0.844187623	2.74E-34
UCS	Cell metabolism gene	MRPL37	SNRPD2	0.847292363	9.03E-35
UCS	Cell metabolism gene	MRPL37	NOP56	0.855905951	3.63E-36
UCS	Cell metabolism gene	MRPL37	PSMC3	0.859606213	8.55E-37
UCS	Cell metabolism gene	MRPL37	PSMD8	0.863560275	1.74E-37
UCS	Cell metabolism gene	MRPL37	PMPCA	0.871847799	5.24E-39
UCS	Cell metabolism gene	MRPL37	DTYMK	0.876447237	6.74E-40
UCS	Cell metabolism gene	MRPL37	EXOSC4	0.879052486	2.03E-40
UCS	Cell metabolism gene	MRPL37	IDH3B	0.888042455	2.61E-42
UCS	Cell metabolism gene	MRPL37	CCT7	0.893270574	1.74E-43
UCS	Cell metabolism gene	MRPL37	TIMM13	0.894377992	9.60E-44
UCS	Cell metabolism gene	MRPL37	POLD2	0.895227767	6.07E-44
UCS	CGC	MRPL37	PRCC	0.804056522	7.20E-29
UCS	CGC	MRPL37	CDK4	0.809898738	1.41E-29
UCS	CGC	MRPL37	TFPT	0.813684985	4.76E-30
UCS	CGC	MRPL37	SDHAF2	0.848794551	5.23E-35
UCS	Epifactor	MRPL37	LAS1L	0.803545568	8.28E-29
UCS	Epifactor	MRPL37	C17orf49	0.80398515	7.34E-29
UCS	Epifactor	MRPL37	PPP4C	0.805452271	4.90E-29
UCS	Epifactor	MRPL37	MBD3	0.807362323	2.88E-29
UCS	Epifactor	MRPL37	TFPT	0.813684985	4.76E-30
UCS	Epifactor	MRPL37	RUVBL2	0.818817694	1.05E-30
UCS	Epifactor	MRPL37	BRMS1	0.823240772	2.74E-31
UCS	Epifactor	MRPL37	EXOSC5	0.824989314	1.60E-31
UCS	Epifactor	MRPL37	NOC2L	0.835221049	5.94E-33
UCS	Epifactor	MRPL37	PRPF31	0.849632894	3.85E-35
UCS	Epifactor	MRPL37	RRP8	0.859132645	1.03E-36
UCS	Epifactor	MRPL37	FBL	0.878857155	2.23E-40
UCS	Epifactor	MRPL37	EXOSC4	0.879052486	2.03E-40
UCS	Epifactor	MRPL37	PRMT1	0.887048933	4.29E-42
UCS	IUPHAR	MRPL37	ECE2	0.801279195	1.53E-28
UCS	IUPHAR	MRPL37	IMPDH2	0.801376476	1.49E-28
UCS	IUPHAR	MRPL37	ATP6V0B	0.808697645	1.98E-29
UCS	IUPHAR	MRPL37	CDK4	0.809898738	1.41E-29
UCS	IUPHAR	MRPL37	SLC27A5	0.822585792	3.35E-31
UCS	IUPHAR	MRPL37	PTGES2	0.82415891	2.06E-31
UCS	IUPHAR	MRPL37	FDPS	0.83042978	2.85E-32
UCS	IUPHAR	MRPL37	EGLN2	0.832018438	1.70E-32
UCS	IUPHAR	MRPL37	USP5	0.834416563	7.75E-33
UCS	IUPHAR	MRPL37	PSMB2	0.840979647	8.42E-34
UCS	IUPHAR	MRPL37	HMOX2	0.842227748	5.46E-34
UCS	IUPHAR	MRPL37	PRMT1	0.887048933	4.29E-42
UCS	Kinase	MRPL37	CDK4	0.809898738	1.41E-29
UCS	Kinase	MRPL37	ADCK4	0.815168728	3.09E-30
UCS	TF	MRPL37	ZNF787	0.805203589	5.25E-29
UCS	TF	MRPL37	MBD3	0.807362323	2.88E-29
UCS	TF	MRPL37	REXO4	0.828506044	5.28E-32
UCS	TF	MRPL37	ZNF581	0.869419563	1.50E-38
UCS	TSG	MRPL37	NME1	0.811170035	9.82E-30
UCS	TSG	MRPL37	BRMS1	0.823240772	2.74E-31
UCS	TSG	MRPL37	STUB1	0.826538925	9.83E-32
UCS	TSG	MRPL37	TSSC4	0.866408449	5.37E-38
UCS	TSG	MRPL37	PHB	0.876973383	5.31E-40
UVM	Cell metabolism gene	MRPL37	LYPLA2	0.845200648	6.34E-23
UVM	Cell metabolism gene	MRPL37	ENO1	0.850570452	1.78E-23
UVM	Epifactor	MRPL37	DMAP1	0.805534902	2.08E-19
UVM	Epifactor	MRPL37	NOC2L	0.894410314	5.55E-29
UVM	TSG	MRPL37	DNAJC11	0.874556845	3.12E-26

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRC	MRPL37	MRPL11	-1.04966837625557	0.000354478033746394
KIRC	MRPL37	MRPL24	-1.34802117098363	0.000369980864421695
LUSC	MRPL37	MRPL39	-3.50411737429004	0.000985010025625636
COAD	MRPL37	MRPL41	-2.99561502382389	0.00144392251968384
KIRP	MRPL37	MRPL45	1.87807739970193	0.00239070039242506
KICH	MRPL37	MRPL24	1.42000841970622	0.00378090143203735
CHOL	MRPL37	MRPL41	-4.96379377542225	0.00390625
BLCA	MRPL37	MRPL39	1.69896851960452	0.00391769409179688
LUAD	MRPL37	MRPL39	-1.1049452981592	0.00471395891927286
THCA	MRPL37	MRPL41	-3.88188543554269	0.00492925389458784
BRCA	MRPL37	MRPL45	-1.03506189808523	0.00606673423231317
PRAD	MRPL37	ICT1	-1.54848444909352	0.00907723161841939
KIRP	MRPL37	MRPL24	-2.9092481117556	0.0139979305677116
STAD	MRPL37	MRPL4	1.4393539135682	0.0279771662317216
COAD	MRPL37	MRPL39	-1.15285953291756	0.0357243716716767
LUAD	MRPL37	MRPL24	-3.53731160751159	1.10656371043093e-09
PRAD	MRPL37	MRPL11	1.12581653394628	1.15996224044503e-05
LUAD	MRPL37	MRPL45	-5.01573645436195	1.46641795486149e-06
KIRP	MRPL37	MRPL49	-2.36524030474784	1.53668224811554e-08
LUAD	MRPL37	MRPL42	-6.34610249602491	2.48255276366547e-08
LIHC	MRPL37	MRPL24	1.01230339617377	2.71217975233539e-06
BRCA	MRPL37	ICT1	-4.17488220449664	2.73719348917167e-14
COAD	MRPL37	MRPL4	2.77705897514473	2.98023223876954e-07
LUSC	MRPL37	MRPL40	-8.45997214407498	3.09303724812157e-05
LIHC	MRPL37	MRPL39	-1.65461683386216	3.95799979560965e-08
PRAD	MRPL37	MRPL41	1.31179686307216	4.41809300064344e-05
KIRC	MRPL37	MRPL42	-4.382095336248	5.26630854166927e-06
THCA	MRPL37	MRPL49	-1.28871899028168	5.42468304941934e-06
LUSC	MRPL37	MRPL45	-5.82595523569917	5.84081463924049e-06
LUSC	MRPL37	ICT1	-3.23093376049456	6.60526357089358e-07
KICH	MRPL37	MRPL41	1.05103651319563	7.49826431274414e-05
LUSC	MRPL37	MRPL24	-2.80841690659614	7.95689711347621e-09

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with MRPL37

HNRNPA1, ICT1, TK1, SMN1, TCF3, CUL3, MRPL9, MRPL39, MRPL38, MRPL24, MRPL44, MRPL41, MRPL32, MRPL50, MRPL45, MRPL51, MRPL2, MRPL40, MRPL42, MRPL12, TSR1, HNRNPM, ABCC2, FAF2, DLD, UBC, NPM1, ENO1, SHMT2, MOV10, NXF1, BTRC, MRPL28, MRPL4, HSPD1, MRPL46, MRPL11, MRPL3, PDPR, MRPL49, PDP1, MRPL27, MRPL55, MALSU1, MRPL47, MRPL16, ACOT2, MRPL13, PM20D2, GADD45GIP1, MRPL15, MRPS30, MRPL30, DHRS4, MRPL14, AGPS, ATP5L, MRPL17, CYC1, MRPL18, MRPL22, MTCH2, PDCD6, STOML2, UQCRC2, NTRK1, MRPL1, Mapre1, Cdc26, Brwd3, NANOG, DNLZ, CYLD, TRIM25, KCTD10, LEO1, MRPS21, MRPS28, MRPS5, GATB, PGK1, EGLN3, PRKCZ, FGF11, MEPCE, LARP7, RECQL4, SERBP1, RPS6, TGOLN2, MRM1, PDK1, TRMT61B, AURKAIP1, LTN1, KIAA1429, KRAS, BIRC3, TRIM28, PLEKHA4, EMC1, IMMP1L, IMMP2L, GRSF1, ELAVL1, ZC3HAV1, ANLN, ACAD9, AUH, C12orf65, C17orf80, C1QBP, C21orf33, C6orf203, MCUR1, CCDC90B, CHCHD1, COX15, CS, DDX28, DHX30, FASTKD3, FASTKD5, GFM1, GFM2, HINT2, LRPPRC, CCDC109B, MDH2, METTL15, METTL17, MRPS12, MRPS26, MRRF, MTERF3, MTFMT, MTG2, MTIF2, MTIF3, MTRF1, MTRF1L, NGRN, OTC, PMPCA, PMPCB, RMND1, RPUSD4, SLIRP, SSBP1, SURF1, TACO1, TBRG4, TEFM, TFAM, TMEM70, TRUB2, TSFM, TUFM, VWA8, EXD2, NR3C1, DNAJA3, DNAJC15, DNAJC28, HSCB, AARS2, COX4I1, COX8A, PDHA1, TRAP1, NAA40, RPL37, YBX2, YBX1, RBMS2, H1FNT, MRPL53, MRPL21, RPL10, NEIL1, MRPL52, RPS8, MRPL33, NDUFAB1, OXA1L, MRPL10, LONP1, MRPL23, MRPS18A, RPL13A, MRPL35, MRPL19, MRPL57, MRPL34, MRPL43, MRPL20, RPL19, MRPL48, WIPI1, SREK1, Taf15, FBXO32, CCNF, KLF12, KLF15,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
MRPL37	LIHC	chr1	54683856	54683856	C	G	Silent		4
MRPL37	UCS	chr1	54681910	54681910	G	A	Missense_Mutation	p.D363N	3
MRPL37	ESCA	chr1	54670828	54670828	C	T	Missense_Mutation	p.R162C	3
MRPL37	PAAD	chr1	54670848	54670848	G	A	Silent	p.E168E	3
MRPL37	UCEC	chr1	54681841	54681841	G	A	Missense_Mutation	p.V340M	3
MRPL37	UCEC	chr1	54675789	54675789	G	A	Missense_Mutation	p.V273M	3
MRPL37	ACC	chr1	54678298	54678298	C	T	Silent	p.G319G	3
MRPL37	SKCM	chr1	54665994	54665994	G	A	Silent	p.P26P	2
MRPL37	BLCA	chr1	54670971	54670971	G	A	Silent	p.P178P	2
MRPL37	ESCA	chr1	54670731	54670731	A	G	Missense_Mutation	p.I129M	2
MRPL37	ESCA	chr1	54670828	54670828	C	T	Missense_Mutation		2
MRPL37	PAAD	chr1	54670848	54670848	G	A	Silent		2
MRPL37	LIHC	chr1	54666261	54666261	G	-	Splice_Site	p.E115_splice	2
MRPL37	STAD	chr1	54671061	54671061	G	A	Silent		2
MRPL37	UCEC	chr1	54666157	54666157	G	A	Missense_Mutation	p.G81S	2
MRPL37	SKCM	chr1	54681876	54681876	C	T	Silent	p.V351V	2
MRPL37	STAD	chr1	54671061	54671061	G	A	Silent	p.T208T	2
MRPL37	UCEC	chr1	54675706	54675706	T	G	Missense_Mutation	p.I245S	2
MRPL37	HNSC	chr1	54681872	54681872	G	A	Missense_Mutation	p.R350H	2
MRPL37	SKCM	chr1	54678283	54678283	C	T	Silent	p.I314I	2
MRPL37	LUAD	chr1	54665932	54665932	G	C	Missense_Mutation	p.G6R	2
MRPL37	UCEC	chr1	54683871	54683871	G	T	Missense_Mutation	p.K407N	2
MRPL37	SKCM	chr1	54666161	54666161	A	G	Missense_Mutation	p.Y82C	2
MRPL37	STAD	chr1	54666207	54666207	G	A	Silent	p.P97P	2
MRPL37	UCEC	chr1	54683893	54683893	T	A	Missense_Mutation	p.L415I	2
MRPL37	BLCA	chr1	54666234	54666234	C	G	Missense_Mutation		1
MRPL37	HNSC	chr1	54665941	54665950	AGGCGGGCGC	-	Frame_Shift_Del	p.RRAL9fs	1
MRPL37	BLCA	chr1	54675719	54675719	G	A	Silent	p.K249K	1
MRPL37	LIHC	chr1	54682017	54682017	G	T	Silent		1
MRPL37	STAD	chr1	54666084	54666085	-	C	Frame_Shift_Ins	p.H57fs	1
MRPL37	COAD	chr1	54681870	54681870	A	G	Silent	p.G349G	1
MRPL37	LUAD	chr1	54666245	54666246	-	T	Frame_Shift_Ins	p.R110fs	1
MRPL37	UCS	chr1	54681910	54681910	G	A	Missense_Mutation		1
MRPL37	BLCA	chr1	54678280	54678280	G	A	Missense_Mutation		1
MRPL37	KIRP	chr1	54671037	54671037	G	A	Silent	p.R200R	1
MRPL37	SKCM	chr1	54665980	54665980	G	A	Missense_Mutation	p.G22S	1
MRPL37	LIHC	chr1	54666136	54666136	A	G	Missense_Mutation	p.I74V	1
MRPL37	TGCT	chr1	54681920	54681920	G	C	Missense_Mutation		1
MRPL37	LUSC	chr1	54670798	54670798	G	A	Missense_Mutation	p.E152K	1
MRPL37	SKCM	chr1	54666249	54666249	C	T	Missense_Mutation	p.A81V	1
MRPL37	BLCA	chr1	54675719	54675719	G	A	Silent		1
MRPL37	KIRP	chr1	54666190	54666190	C	A	Missense_Mutation		1
MRPL37	BLCA	chr1	54670818	54670818	C	T	Silent	p.I158I	1
MRPL37	LIHC	chr1	54681856	54681856	G	A	Missense_Mutation	p.V345M	1
MRPL37	THYM	chr1	54681931	54681931	G	T	Missense_Mutation		1
MRPL37	LUSC	chr1	54681865	54681865	G	T	Missense_Mutation	p.D348Y	1
MRPL37	KIRP	chr1	54671080	54671080	C	A	Silent		1
MRPL37	SKCM	chr1	54666050	54666050	C	T	Missense_Mutation	p.P45L	1
MRPL37	BLCA	chr1	54670971	54670971	G	A	Silent		1
MRPL37	BLCA	chr1	54670833	54670833	C	A	Silent	p.L163L	1
MRPL37	LIHC	chr1	54675792	54675792	A	-	Frame_Shift_Del	p.K274fs	1
MRPL37	THYM	chr1	54665934	54665934	G	A	Silent	p.G6G	1
MRPL37	BLCA	chr1	54670818	54670818	C	T	Silent		1
MRPL37	LGG	chr1	54678284	54678284	C	A	Missense_Mutation	p.L315M	1
MRPL37	SKCM	chr1	54670738	54670738	C	T	Missense_Mutation	p.L132F	1
MRPL37	CESC	chr1	54675624	54675624	C	A	Missense_Mutation		1
MRPL37	LIHC	chr1	54678292	54678292	T	-	Frame_Shift_Del	p.A317fs	1
MRPL37	UCEC	chr1	54670797	54670797	C	T	Silent	p.D151D	1
MRPL37	ESCA	chr1	54670731	54670731	A	G	Missense_Mutation		1
MRPL37	BLCA	chr1	54670833	54670833	C	A	Silent		1
MRPL37	LGG	chr1	54681864	54681864	G	A	Silent	p.T347T	1
MRPL37	SKCM	chr1	54678204	54678204	C	T	Missense_Mutation	p.P288L	1
MRPL37	CESC	chr1	54675624	54675624	C	A	Missense_Mutation	p.L218I	1
MRPL37	HNSC	chr1	54681872	54681872	G	A	Missense_Mutation		1
MRPL37	PCPG	chr1	54665938	54665938	G	A	Missense_Mutation		1
MRPL37	BLCA	chr1	54678230	54678230	G	A	Missense_Mutation	p.A297T	1
MRPL37	LGG	chr1	54678284	54678284	C	A	Missense_Mutation		1
MRPL37	CESC	chr1	54683899	54683899	C	G	Missense_Mutation	p.L417V	1
MRPL37	LUAD	chr1	54683911	54683911	G	T	Missense_Mutation	p.G421C	1
MRPL37	HNSC	chr1	54675803	54675803	A	G	Silent		1
MRPL37	SARC	chr1	54670690	54670690	G	T	Splice_Site		1
MRPL37	BLCA	chr1	54675780	54675780	A	G	Missense_Mutation	p.I270V	1
MRPL37	LGG	chr1	54681864	54681864	G	A	Silent		1
MRPL37	STAD	chr1	54666084	54666085	-	-	Frame_Shift_Ins		1
MRPL37	CESC	chr1	54649831	54649831	G	C	RNA	NULL	1
MRPL37	LUAD	chr1	54675622	54675622	C	G	Missense_Mutation	p.S217C	1
MRPL37	BLCA	chr1	54678230	54678230	G	A	Missense_Mutation		1
MRPL37	HNSC	chr1	54665941	54665950	AGGCGGGCGC	-	Frame_Shift_Del		1
MRPL37	BLCA	chr1	54666259	54666259	G	A	Missense_Mutation	p.E115K	1
MRPL37	COAD	chr1	54670693	54670693	G	A	Missense_Mutation	p.V117I	1
MRPL37	LUAD	chr1	54675729	54675729	C	T	Silent	p.L253L	1
MRPL37	BLCA	chr1	54675780	54675780	A	G	Missense_Mutation		1
MRPL37	BLCA	chr1	54666234	54666234	C	G	Missense_Mutation	p.I106M	1
MRPL37	LIHC	chr1	54681856	54681856	G	A	Missense_Mutation		1
MRPL37	STAD	chr1	54666084	54666085	-	C	Frame_Shift_Ins	p.E56fs	1
MRPL37	COAD	chr1	54670966	54670966	A	G	Splice_Site	.	1
MRPL37	BLCA	chr1	54666259	54666259	G	A	Missense_Mutation		1
MRPL37	HNSC	chr1	54675803	54675803	A	G	Splice_Site	p.T277_splice	1
MRPL37	BLCA	chr1	54678280	54678280	G	A	Missense_Mutation	p.M313I	1
MRPL37	LIHC	chr1	54675767	54675767	T	C	Silent		1
MRPL37	COAD	chr1	54666225	54666225	C	T	Silent	p.A103A	1
MRPL37	LUAD	chr1	54666245	54666246	-	T	Frame_Shift_Ins	p.L110fs	1

Copy number variation (CNV) of MRPL37
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across MRPL37
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
95033	N/A	AX381275	ANKFN1	chr17	54307019	-	MRPL37	chr1	54684051	-
95033	UCEC	TCGA-BG-A3PP-01A	EPHA2	chr1	16474873	-	MRPL37	chr1	54670691	+
95033	N/A	FN159067	GPR78	chr4	8580483	-	MRPL37	chr1	54675784	-
92560	THCA	TCGA-DJ-A2PY-01A	MRPL37	chr1	54666262	+	ARHGEF10L	chr1	17913955	+
55029	STAD	TCGA-BR-4357-01A	MRPL37	chr1	54666262	-	MASP2	chr1	11090939	-
55029	READ	TCGA-AG-3731-01A	MRPL37	chr1	54671083	+	SLC52A1	chr17	4936464	-
67848	READ	TCGA-AG-3731	MRPL37	chr1	54671083	+	SLC52A2	chr8	145584462	+
95034	PRAD	TCGA-KK-A7AW-01A	TTC39A	chr1	51771649	-	MRPL37	chr1	54681814	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
HNSC	MRPL37	0.00379875458924196	0.11
LIHC	MRPL37	0.00723697962860569	0.2
LAML	MRPL37	0.0449773943352915	1

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
TGCT	MRPL37	0.0332356870952638	0.83
THCA	MRPL37	6.1180398677502e-05	0.002
KICH	MRPL37	0.00954966956344294	0.28
BRCA	MRPL37	7.99367449998503e-05	0.0026
PRAD	MRPL37	0.0174580754543382	0.47
PAAD	MRPL37	0.0402756503611811	0.97
OV	MRPL37	0.00852650394533131	0.26
UCEC	MRPL37	0.0137714667486817	0.39
THYM	MRPL37	0.0491427097298416	1
SARC	MRPL37	0.00175724520519981	0.054
HNSC	MRPL37	0.0272818880366444	0.71

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source