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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: MRPL27 (NCBI Gene ID:51264)

Gene Summary

Gene Summary

Gene Information	Gene Name: MRPL27
	Gene ID: 51264
	Gene Symbol	MRPL27
	Gene ID	51264
	Gene Name	mitochondrial ribosomal protein L27
	Synonyms	L27mt
	Cytomap	17q21.33
	Type of Gene	protein-coding
	Description	39S ribosomal protein L27, mitochondrialMRP-L27mitochondrial large ribosomal subunit protein bL27m
	Modification date	20200313
	UniProtAcc	Q9P0M9

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
MRPL27	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'MRPL27[title] AND translation [title] AND human.'

Gene	Title	PMID
MRPL27	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000225969	48447392	48447460	Frame-shift
ENST00000225969	48447815	48447947	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000225969	48447815	48447947	733	85	216	148	13	57

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
Q9P0M9	13	57	1	30	Transit peptide	Note=Mitochondrion;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q32PC3
Q9P0M9	13	57	31	148	Chain	ID=PRO_0000181229;Note=39S ribosomal protein L27%2C mitochondrial
Q9P0M9	13	57	24	24	Natural variant	ID=VAR_052023;Note=T->A;Dbxref=dbSNP:rs17776919
Q9P0M9	13	57	52	55	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5OOM

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
BLCA	MRPL27	-4.19270554058168	0.00202178955078125
BRCA	MRPL27	-1.5584165725499	1.16393956539382e-08
LUAD	MRPL27	-1.39404329671842	3.44055922076328e-05
LUSC	MRPL27	-1.81809468729316	3.90393047420304e-06

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
KICH	MRPL27	hsa-miR-18a-5p	87	-0.31875802555377	0.00419499435775023
UCEC	MRPL27	hsa-miR-18a-5p	87	-0.359816653934301	0.0372731731240433
UCEC	MRPL27	hsa-miR-330-3p	95	-0.369289533995416	0.0322945061355754

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type

Gene

Coefficient

Pvalue

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with MRPL27 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
ACC	Cell metabolism gene	MRPL27	PSMB3	0.833041253	1.73E-21
CESC	Cell metabolism gene	MRPL27	PSMB3	0.821501578	1.23E-76
DLBC	Cell metabolism gene	MRPL27	PSMD8	0.80077199	8.32E-12
DLBC	Cell metabolism gene	MRPL27	MMAB	0.802958302	6.62E-12
DLBC	Cell metabolism gene	MRPL27	PPCDC	0.806587685	4.51E-12
DLBC	Cell metabolism gene	MRPL27	PGLS	0.808883182	3.52E-12
DLBC	Cell metabolism gene	MRPL27	SAT2	0.809560374	3.27E-12
DLBC	Cell metabolism gene	MRPL27	PAFAH1B3	0.809572397	3.26E-12
DLBC	Cell metabolism gene	MRPL27	TSTA3	0.810329892	3.00E-12
DLBC	Cell metabolism gene	MRPL27	TBCB	0.811452844	2.65E-12
DLBC	Cell metabolism gene	MRPL27	DAD1	0.815784249	1.63E-12
DLBC	Cell metabolism gene	MRPL27	PSMB10	0.816479994	1.51E-12
DLBC	Cell metabolism gene	MRPL27	POLR2H	0.816513444	1.50E-12
DLBC	Cell metabolism gene	MRPL27	LYPLA2	0.818513138	1.20E-12
DLBC	Cell metabolism gene	MRPL27	TIMM9	0.818622441	1.18E-12
DLBC	Cell metabolism gene	MRPL27	GUK1	0.819214592	1.10E-12
DLBC	Cell metabolism gene	MRPL27	FPGS	0.822132678	7.84E-13
DLBC	Cell metabolism gene	MRPL27	IDH3B	0.82264608	7.38E-13
DLBC	Cell metabolism gene	MRPL27	PFDN4	0.824285873	6.08E-13
DLBC	Cell metabolism gene	MRPL27	LSM2	0.825252106	5.41E-13
DLBC	Cell metabolism gene	MRPL27	MED27	0.825421311	5.30E-13
DLBC	Cell metabolism gene	MRPL27	SNRPE	0.827258314	4.25E-13
DLBC	Cell metabolism gene	MRPL27	PMPCA	0.828120496	3.82E-13
DLBC	Cell metabolism gene	MRPL27	MTX1	0.828676192	3.57E-13
DLBC	Cell metabolism gene	MRPL27	GEMIN7	0.829978788	3.04E-13
DLBC	Cell metabolism gene	MRPL27	LSM3	0.831013246	2.67E-13
DLBC	Cell metabolism gene	MRPL27	POLR2J	0.833135667	2.05E-13
DLBC	Cell metabolism gene	MRPL27	HSD17B10	0.833320321	2.00E-13
DLBC	Cell metabolism gene	MRPL27	SEC61G	0.834480198	1.73E-13
DLBC	Cell metabolism gene	MRPL27	PHPT1	0.83593254	1.43E-13
DLBC	Cell metabolism gene	MRPL27	PSMB1	0.83817314	1.07E-13
DLBC	Cell metabolism gene	MRPL27	MIF	0.838912341	9.73E-14
DLBC	Cell metabolism gene	MRPL27	GFER	0.841205009	7.18E-14
DLBC	Cell metabolism gene	MRPL27	SNRPD3	0.841784847	6.65E-14
DLBC	Cell metabolism gene	MRPL27	LSM4	0.842367404	6.15E-14
DLBC	Cell metabolism gene	MRPL27	B3GAT3	0.844394176	4.67E-14
DLBC	Cell metabolism gene	MRPL27	PHKG2	0.845570235	3.97E-14
DLBC	Cell metabolism gene	MRPL27	TIMM10	0.846686034	3.41E-14
DLBC	Cell metabolism gene	MRPL27	PGP	0.847181824	3.18E-14
DLBC	Cell metabolism gene	MRPL27	TOMM22	0.847362338	3.10E-14
DLBC	Cell metabolism gene	MRPL27	PSMB4	0.848491268	2.65E-14
DLBC	Cell metabolism gene	MRPL27	SNRPB	0.851017557	1.85E-14
DLBC	Cell metabolism gene	MRPL27	PTDSS2	0.852626184	1.47E-14
DLBC	Cell metabolism gene	MRPL27	PFDN5	0.854892652	1.05E-14
DLBC	Cell metabolism gene	MRPL27	DTYMK	0.855376872	9.82E-15
DLBC	Cell metabolism gene	MRPL27	FAU	0.855671325	9.40E-15
DLBC	Cell metabolism gene	MRPL27	ATP5G1	0.858540196	6.12E-15
DLBC	Cell metabolism gene	MRPL27	ACOT8	0.861349284	3.98E-15
DLBC	Cell metabolism gene	MRPL27	TIMM8B	0.861609687	3.83E-15
DLBC	Cell metabolism gene	MRPL27	UROD	0.86248606	3.34E-15
DLBC	Cell metabolism gene	MRPL27	TIMM50	0.87068702	8.90E-16
DLBC	Cell metabolism gene	MRPL27	PSMA7	0.873376582	5.65E-16
DLBC	Cell metabolism gene	MRPL27	EXOSC4	0.876608839	3.23E-16
DLBC	Cell metabolism gene	MRPL27	PSMD4	0.878119051	2.48E-16
DLBC	Cell metabolism gene	MRPL27	DPM2	0.87869448	2.24E-16
DLBC	Cell metabolism gene	MRPL27	PSMB7	0.879674014	1.88E-16
DLBC	Cell metabolism gene	MRPL27	NME2	0.880977893	1.48E-16
DLBC	Cell metabolism gene	MRPL27	ITPA	0.887567089	4.30E-17
DLBC	Cell metabolism gene	MRPL27	POLR2F	0.893044622	1.45E-17
DLBC	Cell metabolism gene	MRPL27	SNRPD2	0.897148375	6.17E-18
DLBC	Cell metabolism gene	MRPL27	PSMC1	0.89850297	4.62E-18
DLBC	Cell metabolism gene	MRPL27	PSMD13	0.904762935	1.14E-18
DLBC	Cell metabolism gene	MRPL27	POLR2L	0.906988656	6.81E-19
DLBC	Cell metabolism gene	MRPL27	POLE4	0.90934035	3.88E-19
DLBC	Cell metabolism gene	MRPL27	PSMC5	0.913826514	1.27E-19
DLBC	Cell metabolism gene	MRPL27	PSMC3	0.913908638	1.24E-19
DLBC	Cell metabolism gene	MRPL27	TIMM13	0.915255232	8.76E-20
DLBC	Cell metabolism gene	MRPL27	PSMB6	0.919130766	3.12E-20
DLBC	Cell metabolism gene	MRPL27	POLR2I	0.920398802	2.20E-20
DLBC	Cell metabolism gene	MRPL27	PSMB3	0.954851812	6.91E-26
DLBC	CGC	MRPL27	SDHAF2	0.812216177	2.44E-12
DLBC	CGC	MRPL27	U2AF1	0.813327265	2.15E-12
DLBC	CGC	MRPL27	ASPSCR1	0.820483046	9.52E-13
DLBC	CGC	MRPL27	NTHL1	0.853650575	1.27E-14
DLBC	CGC	MRPL27	COX6C	0.859036725	5.68E-15
DLBC	CGC	MRPL27	HRAS	0.864237653	2.54E-15
DLBC	CGC	MRPL27	TFPT	0.877628023	2.70E-16
DLBC	Epifactor	MRPL27	HMG20B	0.801648202	7.60E-12
DLBC	Epifactor	MRPL27	RRP8	0.81013768	3.07E-12
DLBC	Epifactor	MRPL27	PAF1	0.828200358	3.79E-13
DLBC	Epifactor	MRPL27	FBL	0.831956897	2.38E-13
DLBC	Epifactor	MRPL27	RUVBL2	0.837676338	1.14E-13
DLBC	Epifactor	MRPL27	PRPF31	0.84691177	3.30E-14
DLBC	Epifactor	MRPL27	DMAP1	0.852945721	1.40E-14
DLBC	Epifactor	MRPL27	ZNHIT1	0.853630647	1.27E-14
DLBC	Epifactor	MRPL27	PPP4C	0.854882993	1.06E-14
DLBC	Epifactor	MRPL27	SIRT6	0.867896235	1.41E-15
DLBC	Epifactor	MRPL27	EXOSC4	0.876608839	3.23E-16
DLBC	Epifactor	MRPL27	TFPT	0.877628023	2.70E-16
DLBC	Epifactor	MRPL27	RBX1	0.885519868	6.37E-17
DLBC	Epifactor	MRPL27	BRMS1	0.886005413	5.81E-17
DLBC	Epifactor	MRPL27	MBD3	0.900251271	3.16E-18
DLBC	IUPHAR	MRPL27	TPRA1	0.800896687	8.22E-12
DLBC	IUPHAR	MRPL27	MMP24	0.812044044	2.48E-12
DLBC	IUPHAR	MRPL27	SLC25A26	0.817786948	1.30E-12
DLBC	IUPHAR	MRPL27	SLC25A39	0.837370327	1.19E-13
DLBC	IUPHAR	MRPL27	PSMB1	0.83817314	1.07E-13
DLBC	IUPHAR	MRPL27	MFSD2B	0.841278977	7.11E-14
DLBC	IUPHAR	MRPL27	PHKG2	0.845570235	3.97E-14
DLBC	IUPHAR	MRPL27	MPDU1	0.852271495	1.55E-14
DLBC	IUPHAR	MRPL27	BIRC5	0.853386725	1.32E-14
DLBC	IUPHAR	MRPL27	HRAS	0.864237653	2.54E-15
DLBC	IUPHAR	MRPL27	SIRT6	0.867896235	1.41E-15
DLBC	IUPHAR	MRPL27	PSMB6	0.919130766	3.12E-20
DLBC	Kinase	MRPL27	PHKG2	0.845570235	3.97E-14
DLBC	TF	MRPL27	THYN1	0.800315588	8.73E-12
DLBC	TF	MRPL27	HMG20B	0.801648202	7.60E-12
DLBC	TF	MRPL27	IRF3	0.811395942	2.67E-12
DLBC	TF	MRPL27	ZNF444	0.824166663	6.16E-13
DLBC	TF	MRPL27	THAP3	0.84512095	4.23E-14
DLBC	TF	MRPL27	THAP7	0.852278199	1.54E-14
DLBC	TF	MRPL27	THAP4	0.869510397	1.08E-15
DLBC	TF	MRPL27	PIN1	0.880282409	1.68E-16
DLBC	TF	MRPL27	NME2	0.880977893	1.48E-16
DLBC	TF	MRPL27	MBD3	0.900251271	3.16E-18
DLBC	TSG	MRPL27	IRF3	0.811395942	2.67E-12
DLBC	TSG	MRPL27	STUB1	0.815059778	1.77E-12
DLBC	TSG	MRPL27	SIRT6	0.867896235	1.41E-15
DLBC	TSG	MRPL27	PIN1	0.880282409	1.68E-16
DLBC	TSG	MRPL27	BRMS1	0.886005413	5.81E-17
DLBC	TSG	MRPL27	TSSC4	0.893538738	1.31E-17
DLBC	TSG	MRPL27	PARK7	0.894196254	1.15E-17
DLBC	TSG	MRPL27	PHB	0.8941994	1.14E-17
DLBC	TSG	MRPL27	GADD45GIP1	0.943905923	9.05E-24
GBM	Cell metabolism gene	MRPL27	DPM3	0.800383836	1.27E-39
GBM	Cell metabolism gene	MRPL27	MED31	0.806950704	1.00E-40
GBM	Cell metabolism gene	MRPL27	PSMB4	0.809452298	3.70E-41
GBM	Cell metabolism gene	MRPL27	SUCLG1	0.813130459	8.35E-42
GBM	Cell metabolism gene	MRPL27	PFDN5	0.821259586	2.76E-43
GBM	Cell metabolism gene	MRPL27	TIMM10	0.826698693	2.56E-44
GBM	Cell metabolism gene	MRPL27	TIMM8B	0.82777242	1.58E-44
GBM	Cell metabolism gene	MRPL27	ATP5G1	0.839175543	7.84E-47
GBM	Cell metabolism gene	MRPL27	SNRPG	0.850492101	2.64E-49
GBM	Cell metabolism gene	MRPL27	PSMB3	0.870575479	3.05E-54
GBM	CGC	MRPL27	SDHAF2	0.838962495	8.69E-47
GBM	Epifactor	MRPL27	ZNHIT1	0.813260501	7.92E-42
GBM	Epifactor	MRPL27	DPY30	0.857996613	4.63E-51
GBM	IUPHAR	MRPL27	PDZD11	0.811649468	1.53E-41
HNSC	Cell metabolism gene	MRPL27	PSMB3	0.806194516	1.16E-130
HNSC	TSG	MRPL27	GADD45GIP1	0.807153222	3.32E-131
KICH	Cell metabolism gene	MRPL27	MED11	0.823849027	1.16E-23
KIRP	Cell metabolism gene	MRPL27	ATP5G1	0.81464265	6.14E-78
KIRP	Cell metabolism gene	MRPL27	MTX1	0.823081765	7.23E-81
KIRP	Cell metabolism gene	MRPL27	PSMC5	0.83165278	5.25E-84
KIRP	Cell metabolism gene	MRPL27	PSMB3	0.871685248	1.90E-101
KIRP	CGC	MRPL27	COX6C	0.808942544	4.82E-76
KIRP	TSG	MRPL27	GADD45GIP1	0.829910997	2.36E-83
LIHC	Cell metabolism gene	MRPL27	PSMB3	0.847580876	6.47E-118
MESO	TSG	MRPL27	GADD45GIP1	0.805524795	5.12E-21
OV	Cell metabolism gene	MRPL27	NME1	0.822791265	4.51E-77
OV	TSG	MRPL27	NME1	0.822791265	4.51E-77
PCPG	Cell metabolism gene	MRPL27	ATP5G1	0.813161564	2.36E-45
PCPG	Cell metabolism gene	MRPL27	PSMB3	0.826906402	3.97E-48
PRAD	Cell metabolism gene	MRPL27	UROD	0.802723629	4.00E-125
PRAD	Cell metabolism gene	MRPL27	GFER	0.803596603	1.35E-125
PRAD	Cell metabolism gene	MRPL27	PHKG2	0.806862753	2.24E-127
PRAD	Cell metabolism gene	MRPL27	GUK1	0.809090831	1.30E-128
PRAD	Cell metabolism gene	MRPL27	FAU	0.80974887	5.58E-129
PRAD	Cell metabolism gene	MRPL27	DPM2	0.812344544	1.91E-130
PRAD	Cell metabolism gene	MRPL27	B3GAT3	0.813993184	2.18E-131
PRAD	Cell metabolism gene	MRPL27	PGLS	0.814522823	1.08E-131
PRAD	Cell metabolism gene	MRPL27	PSMD4	0.815690708	2.28E-132
PRAD	Cell metabolism gene	MRPL27	GEMIN7	0.815804464	1.96E-132
PRAD	Cell metabolism gene	MRPL27	GPX4	0.818787111	3.49E-134
PRAD	Cell metabolism gene	MRPL27	PMVK	0.820518397	3.26E-135
PRAD	Cell metabolism gene	MRPL27	B4GALT7	0.821954703	4.46E-136
PRAD	Cell metabolism gene	MRPL27	LSM4	0.822336868	2.62E-136
PRAD	Cell metabolism gene	MRPL27	TIMM50	0.823200654	7.85E-137
PRAD	Cell metabolism gene	MRPL27	PSMB7	0.825913223	1.70E-138
PRAD	Cell metabolism gene	MRPL27	POLR2F	0.827352494	2.17E-139
PRAD	Cell metabolism gene	MRPL27	PSMB6	0.828787039	2.72E-140
PRAD	Cell metabolism gene	MRPL27	GPX1	0.833857861	1.53E-143
PRAD	Cell metabolism gene	MRPL27	PFDN5	0.833860812	1.52E-143
PRAD	Cell metabolism gene	MRPL27	IDH3G	0.834889606	3.23E-144
PRAD	Cell metabolism gene	MRPL27	SNRPD2	0.835203322	2.01E-144
PRAD	Cell metabolism gene	MRPL27	PSMC3	0.837736339	4.20E-146
PRAD	Cell metabolism gene	MRPL27	TIMM17B	0.837929735	3.12E-146
PRAD	Cell metabolism gene	MRPL27	ATP5G1	0.842454568	2.60E-149
PRAD	Cell metabolism gene	MRPL27	PSMC1	0.843375608	5.97E-150
PRAD	Cell metabolism gene	MRPL27	HSD17B10	0.844133557	1.77E-150
PRAD	Cell metabolism gene	MRPL27	PPCDC	0.850336981	6.46E-155
PRAD	Cell metabolism gene	MRPL27	PHPT1	0.856370569	1.99E-159
PRAD	Cell metabolism gene	MRPL27	DPM3	0.866672886	1.24E-167
PRAD	Cell metabolism gene	MRPL27	POLR2L	0.871923974	4.41E-172
PRAD	Cell metabolism gene	MRPL27	POLR2I	0.874690967	1.66E-174
PRAD	Cell metabolism gene	MRPL27	PSMB3	0.901166494	4.29E-201
PRAD	Cell metabolism gene	MRPL27	PSMC5	0.901245923	3.48E-201
PRAD	CGC	MRPL27	HRAS	0.826672339	5.75E-139
PRAD	CGC	MRPL27	SDHAF2	0.834710326	4.24E-144
PRAD	CGC	MRPL27	ASPSCR1	0.861907152	9.38E-164
PRAD	Epifactor	MRPL27	PPP4C	0.804852032	2.82E-126
PRAD	Epifactor	MRPL27	SIRT6	0.806042012	6.32E-127
PRAD	Epifactor	MRPL27	C17orf49	0.817529404	1.92E-133
PRAD	Epifactor	MRPL27	DMAP1	0.819311993	1.70E-134
PRAD	Epifactor	MRPL27	BRMS1	0.831836649	3.11E-142
PRAD	Epifactor	MRPL27	TAF10	0.845123877	3.56E-151
PRAD	Epifactor	MRPL27	ZNHIT1	0.862029636	7.49E-164
PRAD	Epifactor	MRPL27	RBX1	0.865755532	7.12E-167
PRAD	IUPHAR	MRPL27	SIRT6	0.806042012	6.32E-127
PRAD	IUPHAR	MRPL27	PHKG2	0.806862753	2.24E-127
PRAD	IUPHAR	MRPL27	PMVK	0.820518397	3.26E-135
PRAD	IUPHAR	MRPL27	HRAS	0.826672339	5.75E-139
PRAD	IUPHAR	MRPL27	PSMB6	0.828787039	2.72E-140
PRAD	IUPHAR	MRPL27	CSNK2B	0.829102255	1.72E-140
PRAD	Kinase	MRPL27	PHKG2	0.806862753	2.24E-127
PRAD	TF	MRPL27	ZNF32	0.80303139	2.73E-125
PRAD	TF	MRPL27	ZNF524	0.805345966	1.52E-126
PRAD	TF	MRPL27	THAP7	0.824472644	1.31E-137
PRAD	TF	MRPL27	THAP3	0.826043605	1.41E-138
PRAD	TSG	MRPL27	SIRT6	0.806042012	6.32E-127
PRAD	TSG	MRPL27	PARK7	0.80665157	2.93E-127
PRAD	TSG	MRPL27	PHB	0.810741614	1.54E-129
PRAD	TSG	MRPL27	STUB1	0.817370284	2.39E-133
PRAD	TSG	MRPL27	BRMS1	0.831836649	3.11E-142
PRAD	TSG	MRPL27	TSSC4	0.833382891	3.12E-143
PRAD	TSG	MRPL27	GADD45GIP1	0.909312822	7.97E-211
TGCT	Cell metabolism gene	MRPL27	NME2	0.816341939	1.52E-38
TGCT	Cell metabolism gene	MRPL27	NT5C	0.850093004	9.75E-45
TGCT	Cell metabolism gene	MRPL27	PSMB3	0.874154648	3.62E-50
TGCT	IUPHAR	MRPL27	NT5C	0.850093004	9.75E-45
TGCT	TF	MRPL27	NME2	0.816341939	1.52E-38
THCA	Cell metabolism gene	MRPL27	B4GALT7	0.802114819	9.88E-130
THCA	Cell metabolism gene	MRPL27	TOMM40	0.808076009	4.12E-133
THCA	Cell metabolism gene	MRPL27	NT5C	0.814696414	5.23E-137
THCA	Cell metabolism gene	MRPL27	B3GAT3	0.815840458	1.07E-137
THCA	Cell metabolism gene	MRPL27	PFDN5	0.818341248	3.21E-139
THCA	Cell metabolism gene	MRPL27	SNRPD2	0.818935667	1.38E-139
THCA	Cell metabolism gene	MRPL27	ITPA	0.820298139	1.98E-140
THCA	Cell metabolism gene	MRPL27	PPCDC	0.822059254	1.58E-141
THCA	Cell metabolism gene	MRPL27	POLR2L	0.826668911	1.82E-144
THCA	Cell metabolism gene	MRPL27	TIMM13	0.827700173	3.89E-145
THCA	Cell metabolism gene	MRPL27	PSMD13	0.830716432	4.04E-147
THCA	Cell metabolism gene	MRPL27	MTX1	0.833306686	7.44E-149
THCA	Cell metabolism gene	MRPL27	PSMC1	0.839876084	2.16E-153
THCA	Cell metabolism gene	MRPL27	MED11	0.843095532	1.08E-155
THCA	Cell metabolism gene	MRPL27	APRT	0.845211299	3.13E-157
THCA	Cell metabolism gene	MRPL27	PSMB1	0.84538831	2.32E-157
THCA	Cell metabolism gene	MRPL27	POLR2I	0.847635848	5.04E-159
THCA	Cell metabolism gene	MRPL27	DPM3	0.8492898	2.89E-160
THCA	Cell metabolism gene	MRPL27	PSMC3	0.850775664	2.16E-161
THCA	Cell metabolism gene	MRPL27	PHPT1	0.854558902	2.55E-164
THCA	Cell metabolism gene	MRPL27	POLR2J	0.854731314	1.87E-164
THCA	Cell metabolism gene	MRPL27	ACOT8	0.855971408	1.96E-165
THCA	Cell metabolism gene	MRPL27	PSMB7	0.857769856	7.17E-167
THCA	Cell metabolism gene	MRPL27	EXOSC4	0.864590098	1.67E-172
THCA	Cell metabolism gene	MRPL27	TIMM8B	0.867092733	1.20E-174
THCA	Cell metabolism gene	MRPL27	PSMB6	0.890617923	3.20E-197
THCA	Cell metabolism gene	MRPL27	PSMC5	0.893382149	3.29E-200
THCA	Cell metabolism gene	MRPL27	PSMB3	0.912055089	7.79E-223
THCA	CGC	MRPL27	HRAS	0.833242612	8.22E-149
THCA	CGC	MRPL27	COX6C	0.840511377	7.66E-154
THCA	CGC	MRPL27	ASPSCR1	0.844536184	9.75E-157
THCA	Epifactor	MRPL27	RUVBL2	0.855044638	1.06E-164
THCA	Epifactor	MRPL27	EXOSC4	0.864590098	1.67E-172
THCA	Epifactor	MRPL27	BRMS1	0.886444674	7.39E-193
THCA	Epifactor	MRPL27	ZNHIT1	0.89367365	1.57E-200
THCA	IUPHAR	MRPL27	PPIA	0.809615625	5.27E-134
THCA	IUPHAR	MRPL27	NT5C	0.814696414	5.23E-137
THCA	IUPHAR	MRPL27	HRAS	0.833242612	8.22E-149
THCA	IUPHAR	MRPL27	PSMB1	0.84538831	2.32E-157
THCA	IUPHAR	MRPL27	PSMB6	0.890617923	3.20E-197
THCA	TSG	MRPL27	NPRL2	0.801077233	3.73E-129
THCA	TSG	MRPL27	AIP	0.806674764	2.63E-132
THCA	TSG	MRPL27	TSSC4	0.811221568	6.06E-135
THCA	TSG	MRPL27	GABARAP	0.816773331	2.91E-138
THCA	TSG	MRPL27	PARK7	0.837732573	6.87E-152
THCA	TSG	MRPL27	BRMS1	0.886444674	7.39E-193
THCA	TSG	MRPL27	GADD45GIP1	0.890359967	6.03E-197
THYM	Cell metabolism gene	MRPL27	SNRPE	0.800539294	1.87E-28
THYM	Cell metabolism gene	MRPL27	DTYMK	0.802107312	1.22E-28
THYM	Cell metabolism gene	MRPL27	PSMA4	0.80217002	1.20E-28
THYM	Cell metabolism gene	MRPL27	GSTZ1	0.804564604	6.26E-29
THYM	Cell metabolism gene	MRPL27	PFDN6	0.805112048	5.38E-29
THYM	Cell metabolism gene	MRPL27	LSM2	0.8059583	4.26E-29
THYM	Cell metabolism gene	MRPL27	GSTP1	0.806369966	3.80E-29
THYM	Cell metabolism gene	MRPL27	POLE4	0.809001108	1.82E-29
THYM	Cell metabolism gene	MRPL27	UROD	0.80990628	1.41E-29
THYM	Cell metabolism gene	MRPL27	HMBS	0.81183204	8.13E-30
THYM	Cell metabolism gene	MRPL27	MED27	0.813844679	4.55E-30
THYM	Cell metabolism gene	MRPL27	PSMC4	0.814870236	3.37E-30
THYM	Cell metabolism gene	MRPL27	SNRPD3	0.815779272	2.58E-30
THYM	Cell metabolism gene	MRPL27	POLR2L	0.816809132	1.91E-30
THYM	Cell metabolism gene	MRPL27	DHRS4	0.817650893	1.49E-30
THYM	Cell metabolism gene	MRPL27	GSS	0.818880774	1.03E-30
THYM	Cell metabolism gene	MRPL27	DHRS4L2	0.821994739	4.01E-31
THYM	Cell metabolism gene	MRPL27	IDH3G	0.822254619	3.71E-31
THYM	Cell metabolism gene	MRPL27	POLD2	0.824568355	1.82E-31
THYM	Cell metabolism gene	MRPL27	OAZ1	0.826476784	1.00E-31
THYM	Cell metabolism gene	MRPL27	PSMB10	0.829319229	4.07E-32
THYM	Cell metabolism gene	MRPL27	NME1	0.82999763	3.27E-32
THYM	Cell metabolism gene	MRPL27	DGUOK	0.833530741	1.04E-32
THYM	Cell metabolism gene	MRPL27	SEC61G	0.83457425	7.36E-33
THYM	Cell metabolism gene	MRPL27	TBCB	0.834727895	6.99E-33
THYM	Cell metabolism gene	MRPL27	DOHH	0.835874341	4.77E-33
THYM	Cell metabolism gene	MRPL27	MMAB	0.835936501	4.68E-33
THYM	Cell metabolism gene	MRPL27	PSMB4	0.838994647	1.67E-33
THYM	Cell metabolism gene	MRPL27	POLR2F	0.840509671	9.90E-34
THYM	Cell metabolism gene	MRPL27	MIF	0.840987098	8.40E-34
THYM	Cell metabolism gene	MRPL27	GFER	0.841058822	8.19E-34
THYM	Cell metabolism gene	MRPL27	LSM4	0.842541109	4.89E-34
THYM	Cell metabolism gene	MRPL27	PSMD13	0.843383883	3.64E-34
THYM	Cell metabolism gene	MRPL27	EXOSC5	0.845242136	1.89E-34
THYM	Cell metabolism gene	MRPL27	ALG3	0.845975047	1.45E-34
THYM	Cell metabolism gene	MRPL27	PIGU	0.846187792	1.34E-34
THYM	Cell metabolism gene	MRPL27	FAU	0.850042225	3.31E-35
THYM	Cell metabolism gene	MRPL27	LCMT1	0.850506178	2.79E-35
THYM	Cell metabolism gene	MRPL27	TIMM17B	0.851381366	2.01E-35
THYM	Cell metabolism gene	MRPL27	PHKG2	0.853122023	1.05E-35
THYM	Cell metabolism gene	MRPL27	PSME2	0.853382072	9.51E-36
THYM	Cell metabolism gene	MRPL27	SLC27A5	0.854195085	6.99E-36
THYM	Cell metabolism gene	MRPL27	GUK1	0.855216964	4.73E-36
THYM	Cell metabolism gene	MRPL27	PGP	0.855427756	4.36E-36
THYM	Cell metabolism gene	MRPL27	MVD	0.855903501	3.63E-36
THYM	Cell metabolism gene	MRPL27	PTGES2	0.857662024	1.84E-36
THYM	Cell metabolism gene	MRPL27	NANS	0.858158758	1.51E-36
THYM	Cell metabolism gene	MRPL27	PSMB6	0.858951457	1.11E-36
THYM	Cell metabolism gene	MRPL27	PMPCA	0.860032844	7.22E-37
THYM	Cell metabolism gene	MRPL27	PHPT1	0.860656971	5.63E-37
THYM	Cell metabolism gene	MRPL27	GEMIN6	0.860885382	5.14E-37
THYM	Cell metabolism gene	MRPL27	GMPPA	0.861010241	4.89E-37
THYM	Cell metabolism gene	MRPL27	GEMIN7	0.864474569	1.20E-37
THYM	Cell metabolism gene	MRPL27	WBSCR22	0.866289106	5.64E-38
THYM	Cell metabolism gene	MRPL27	PFDN5	0.866810608	4.53E-38
THYM	Cell metabolism gene	MRPL27	PPCDC	0.870534165	9.28E-39
THYM	Cell metabolism gene	MRPL27	EBP	0.871094557	7.28E-39
THYM	Cell metabolism gene	MRPL27	PSMB1	0.871327685	6.58E-39
THYM	Cell metabolism gene	MRPL27	UROS	0.871889214	5.15E-39
THYM	Cell metabolism gene	MRPL27	HSD17B10	0.873815722	2.20E-39
THYM	Cell metabolism gene	MRPL27	PSMC3	0.876669403	6.10E-40
THYM	Cell metabolism gene	MRPL27	HMOX2	0.880222503	1.18E-40
THYM	Cell metabolism gene	MRPL27	TIMM10	0.883849492	2.08E-41
THYM	Cell metabolism gene	MRPL27	POLR2J	0.887044069	4.31E-42
THYM	Cell metabolism gene	MRPL27	ITPA	0.889172674	1.47E-42
THYM	Cell metabolism gene	MRPL27	ATP5G1	0.891630582	4.12E-43
THYM	Cell metabolism gene	MRPL27	DPM3	0.891921187	3.54E-43
THYM	Cell metabolism gene	MRPL27	PGLS	0.892808113	2.22E-43
THYM	Cell metabolism gene	MRPL27	POLR2H	0.892809125	2.22E-43
THYM	Cell metabolism gene	MRPL27	PSMC1	0.898638657	9.24E-45
THYM	Cell metabolism gene	MRPL27	PSMD4	0.900669048	2.92E-45
THYM	Cell metabolism gene	MRPL27	TOMM40	0.901489794	1.82E-45
THYM	Cell metabolism gene	MRPL27	APRT	0.902425102	1.06E-45
THYM	Cell metabolism gene	MRPL27	SNRPD2	0.905722726	1.48E-46
THYM	Cell metabolism gene	MRPL27	ACOT8	0.907271094	5.76E-47
THYM	Cell metabolism gene	MRPL27	PSMB7	0.911745227	3.40E-48
THYM	Cell metabolism gene	MRPL27	TIMM8B	0.916620995	1.30E-49
THYM	Cell metabolism gene	MRPL27	MTX1	0.918548882	3.39E-50
THYM	Cell metabolism gene	MRPL27	EXOSC4	0.919434671	1.81E-50
THYM	Cell metabolism gene	MRPL27	TIMM13	0.920364826	9.25E-51
THYM	Cell metabolism gene	MRPL27	DPM2	0.924053962	6.00E-52
THYM	Cell metabolism gene	MRPL27	PSMC5	0.935650857	4.09E-56
THYM	Cell metabolism gene	MRPL27	PSMB3	0.936555595	1.80E-56
THYM	Cell metabolism gene	MRPL27	TIMM50	0.945903937	1.67E-60
THYM	Cell metabolism gene	MRPL27	POLR2I	0.950296106	1.18E-62
THYM	CGC	MRPL27	SDHAF2	0.824384445	1.92E-31
THYM	CGC	MRPL27	MAP2K2	0.826049187	1.15E-31
THYM	CGC	MRPL27	MGMT	0.843327593	3.71E-34
THYM	CGC	MRPL27	RBM10	0.844093138	2.83E-34
THYM	CGC	MRPL27	COX6C	0.847975241	7.05E-35
THYM	CGC	MRPL27	TFPT	0.85755061	1.92E-36
THYM	CGC	MRPL27	ASPSCR1	0.88917742	1.46E-42
THYM	Epifactor	MRPL27	ZGPAT	0.818168447	1.27E-30
THYM	Epifactor	MRPL27	NOC2L	0.826322288	1.05E-31
THYM	Epifactor	MRPL27	PELP1	0.826581072	9.70E-32
THYM	Epifactor	MRPL27	CDK5	0.827993091	6.21E-32
THYM	Epifactor	MRPL27	C17orf49	0.834053899	8.74E-33
THYM	Epifactor	MRPL27	PRMT1	0.835139062	6.10E-33
THYM	Epifactor	MRPL27	MBD3	0.840203188	1.10E-33
THYM	Epifactor	MRPL27	CCDC101	0.8406539	9.42E-34
THYM	Epifactor	MRPL27	PAF1	0.844657466	2.32E-34
THYM	Epifactor	MRPL27	EXOSC5	0.845242136	1.89E-34
THYM	Epifactor	MRPL27	PPP4C	0.847037872	9.90E-35
THYM	Epifactor	MRPL27	RUVBL2	0.849044244	4.77E-35
THYM	Epifactor	MRPL27	FBL	0.855414082	4.39E-36
THYM	Epifactor	MRPL27	TFPT	0.85755061	1.92E-36
THYM	Epifactor	MRPL27	LAS1L	0.860969558	4.97E-37
THYM	Epifactor	MRPL27	INO80E	0.867766413	3.03E-38
THYM	Epifactor	MRPL27	TAF10	0.876039722	8.12E-40
THYM	Epifactor	MRPL27	BRMS1	0.902352186	1.10E-45
THYM	Epifactor	MRPL27	SIRT6	0.916318013	1.60E-49
THYM	Epifactor	MRPL27	ZNHIT1	0.917250267	8.41E-50
THYM	Epifactor	MRPL27	EXOSC4	0.919434671	1.81E-50
THYM	Epifactor	MRPL27	PRPF31	0.93093144	2.48E-54
THYM	IUPHAR	MRPL27	EGLN2	0.80480456	5.86E-29
THYM	IUPHAR	MRPL27	SLC25A39	0.814790096	3.45E-30
THYM	IUPHAR	MRPL27	SLC39A3	0.814890453	3.35E-30
THYM	IUPHAR	MRPL27	MAP2K2	0.826049187	1.15E-31
THYM	IUPHAR	MRPL27	PPIA	0.826207228	1.09E-31
THYM	IUPHAR	MRPL27	CDK5	0.827993091	6.21E-32
THYM	IUPHAR	MRPL27	FKBP1A	0.829993585	3.28E-32
THYM	IUPHAR	MRPL27	MPDU1	0.831823472	1.81E-32
THYM	IUPHAR	MRPL27	PRMT1	0.835139062	6.10E-33
THYM	IUPHAR	MRPL27	MMP24	0.839410815	1.44E-33
THYM	IUPHAR	MRPL27	SIRT3	0.839551594	1.38E-33
THYM	IUPHAR	MRPL27	PHKG2	0.853122023	1.05E-35
THYM	IUPHAR	MRPL27	SLC27A5	0.854195085	6.99E-36
THYM	IUPHAR	MRPL27	MVD	0.855903501	3.63E-36
THYM	IUPHAR	MRPL27	PTGES2	0.857662024	1.84E-36
THYM	IUPHAR	MRPL27	PSMB6	0.858951457	1.11E-36
THYM	IUPHAR	MRPL27	PSMB1	0.871327685	6.58E-39
THYM	IUPHAR	MRPL27	HMOX2	0.880222503	1.18E-40
THYM	IUPHAR	MRPL27	ATP6V0B	0.891959859	3.47E-43
THYM	IUPHAR	MRPL27	SIRT6	0.916318013	1.60E-49
THYM	Kinase	MRPL27	FASTK	0.823945158	2.21E-31
THYM	Kinase	MRPL27	MAP2K2	0.826049187	1.15E-31
THYM	Kinase	MRPL27	CDK5	0.827993091	6.21E-32
THYM	Kinase	MRPL27	PHKG2	0.853122023	1.05E-35
THYM	TF	MRPL27	ZNF668	0.805266017	5.16E-29
THYM	TF	MRPL27	ZNF580	0.811692673	8.46E-30
THYM	TF	MRPL27	ZGPAT	0.818168447	1.27E-30
THYM	TF	MRPL27	CENPB	0.821284304	4.99E-31
THYM	TF	MRPL27	REXO4	0.821634671	4.48E-31
THYM	TF	MRPL27	THAP3	0.830405753	2.87E-32
THYM	TF	MRPL27	ZNF511	0.831458047	2.04E-32
THYM	TF	MRPL27	DRAP1	0.835833232	4.84E-33
THYM	TF	MRPL27	MBD3	0.840203188	1.10E-33
THYM	TF	MRPL27	ZNF428	0.840859523	8.78E-34
THYM	TF	MRPL27	GLI4	0.841639216	6.70E-34
THYM	TF	MRPL27	THAP7	0.847270273	9.10E-35
THYM	TF	MRPL27	ZNF524	0.851326355	2.06E-35
THYM	TF	MRPL27	ZNF688	0.851352834	2.04E-35
THYM	TF	MRPL27	ZNF581	0.863131574	2.07E-37
THYM	TF	MRPL27	ZNF32	0.871635162	5.75E-39
THYM	TF	MRPL27	ZNF787	0.917942162	5.19E-50
THYM	TSG	MRPL27	TUSC2	0.800673596	1.80E-28
THYM	TSG	MRPL27	PYCARD	0.805177353	5.29E-29
THYM	TSG	MRPL27	ZNF668	0.805266017	5.16E-29
THYM	TSG	MRPL27	GSTP1	0.806369966	3.80E-29
THYM	TSG	MRPL27	NME1	0.82999763	3.27E-32
THYM	TSG	MRPL27	MAD1L1	0.837184609	3.08E-33
THYM	TSG	MRPL27	SIRT3	0.839551594	1.38E-33
THYM	TSG	MRPL27	PARK7	0.843201322	3.88E-34
THYM	TSG	MRPL27	STUB1	0.844428131	2.52E-34
THYM	TSG	MRPL27	GABARAP	0.852161101	1.51E-35
THYM	TSG	MRPL27	NPRL2	0.86801116	2.73E-38
THYM	TSG	MRPL27	PHB	0.871121759	7.20E-39
THYM	TSG	MRPL27	TSSC4	0.89761618	1.64E-44
THYM	TSG	MRPL27	BRMS1	0.902352186	1.10E-45
THYM	TSG	MRPL27	SIRT6	0.916318013	1.60E-49
THYM	TSG	MRPL27	GADD45GIP1	0.957565596	1.11E-66
UCEC	Cell metabolism gene	MRPL27	PSMC5	0.804843555	5.67E-47
UCEC	TSG	MRPL27	GADD45GIP1	0.829403162	3.26E-52
UCS	Cell metabolism gene	MRPL27	SNRPE	0.800539294	1.87E-28
UCS	Cell metabolism gene	MRPL27	DTYMK	0.802107312	1.22E-28
UCS	Cell metabolism gene	MRPL27	PSMA4	0.80217002	1.20E-28
UCS	Cell metabolism gene	MRPL27	GSTZ1	0.804564604	6.26E-29
UCS	Cell metabolism gene	MRPL27	PFDN6	0.805112048	5.38E-29
UCS	Cell metabolism gene	MRPL27	LSM2	0.8059583	4.26E-29
UCS	Cell metabolism gene	MRPL27	GSTP1	0.806369966	3.80E-29
UCS	Cell metabolism gene	MRPL27	POLE4	0.809001108	1.82E-29
UCS	Cell metabolism gene	MRPL27	UROD	0.80990628	1.41E-29
UCS	Cell metabolism gene	MRPL27	HMBS	0.81183204	8.13E-30
UCS	Cell metabolism gene	MRPL27	MED27	0.813844679	4.55E-30
UCS	Cell metabolism gene	MRPL27	PSMC4	0.814870236	3.37E-30
UCS	Cell metabolism gene	MRPL27	SNRPD3	0.815779272	2.58E-30
UCS	Cell metabolism gene	MRPL27	POLR2L	0.816809132	1.91E-30
UCS	Cell metabolism gene	MRPL27	DHRS4	0.817650893	1.49E-30
UCS	Cell metabolism gene	MRPL27	GSS	0.818880774	1.03E-30
UCS	Cell metabolism gene	MRPL27	DHRS4L2	0.821994739	4.01E-31
UCS	Cell metabolism gene	MRPL27	IDH3G	0.822254619	3.71E-31
UCS	Cell metabolism gene	MRPL27	POLD2	0.824568355	1.82E-31
UCS	Cell metabolism gene	MRPL27	OAZ1	0.826476784	1.00E-31
UCS	Cell metabolism gene	MRPL27	PSMB10	0.829319229	4.07E-32
UCS	Cell metabolism gene	MRPL27	NME1	0.82999763	3.27E-32
UCS	Cell metabolism gene	MRPL27	DGUOK	0.833530741	1.04E-32
UCS	Cell metabolism gene	MRPL27	SEC61G	0.83457425	7.36E-33
UCS	Cell metabolism gene	MRPL27	TBCB	0.834727895	6.99E-33
UCS	Cell metabolism gene	MRPL27	DOHH	0.835874341	4.77E-33
UCS	Cell metabolism gene	MRPL27	MMAB	0.835936501	4.68E-33
UCS	Cell metabolism gene	MRPL27	PSMB4	0.838994647	1.67E-33
UCS	Cell metabolism gene	MRPL27	POLR2F	0.840509671	9.90E-34
UCS	Cell metabolism gene	MRPL27	MIF	0.840987098	8.40E-34
UCS	Cell metabolism gene	MRPL27	GFER	0.841058822	8.19E-34
UCS	Cell metabolism gene	MRPL27	LSM4	0.842541109	4.89E-34
UCS	Cell metabolism gene	MRPL27	PSMD13	0.843383883	3.64E-34
UCS	Cell metabolism gene	MRPL27	EXOSC5	0.845242136	1.89E-34
UCS	Cell metabolism gene	MRPL27	ALG3	0.845975047	1.45E-34
UCS	Cell metabolism gene	MRPL27	PIGU	0.846187792	1.34E-34
UCS	Cell metabolism gene	MRPL27	FAU	0.850042225	3.31E-35
UCS	Cell metabolism gene	MRPL27	LCMT1	0.850506178	2.79E-35
UCS	Cell metabolism gene	MRPL27	TIMM17B	0.851381366	2.01E-35
UCS	Cell metabolism gene	MRPL27	PHKG2	0.853122023	1.05E-35
UCS	Cell metabolism gene	MRPL27	PSME2	0.853382072	9.51E-36
UCS	Cell metabolism gene	MRPL27	SLC27A5	0.854195085	6.99E-36
UCS	Cell metabolism gene	MRPL27	GUK1	0.855216964	4.73E-36
UCS	Cell metabolism gene	MRPL27	PGP	0.855427756	4.36E-36
UCS	Cell metabolism gene	MRPL27	MVD	0.855903501	3.63E-36
UCS	Cell metabolism gene	MRPL27	PTGES2	0.857662024	1.84E-36
UCS	Cell metabolism gene	MRPL27	NANS	0.858158758	1.51E-36
UCS	Cell metabolism gene	MRPL27	PSMB6	0.858951457	1.11E-36
UCS	Cell metabolism gene	MRPL27	PMPCA	0.860032844	7.22E-37
UCS	Cell metabolism gene	MRPL27	PHPT1	0.860656971	5.63E-37
UCS	Cell metabolism gene	MRPL27	GEMIN6	0.860885382	5.14E-37
UCS	Cell metabolism gene	MRPL27	GMPPA	0.861010241	4.89E-37
UCS	Cell metabolism gene	MRPL27	GEMIN7	0.864474569	1.20E-37
UCS	Cell metabolism gene	MRPL27	WBSCR22	0.866289106	5.64E-38
UCS	Cell metabolism gene	MRPL27	PFDN5	0.866810608	4.53E-38
UCS	Cell metabolism gene	MRPL27	PPCDC	0.870534165	9.28E-39
UCS	Cell metabolism gene	MRPL27	EBP	0.871094557	7.28E-39
UCS	Cell metabolism gene	MRPL27	PSMB1	0.871327685	6.58E-39
UCS	Cell metabolism gene	MRPL27	UROS	0.871889214	5.15E-39
UCS	Cell metabolism gene	MRPL27	HSD17B10	0.873815722	2.20E-39
UCS	Cell metabolism gene	MRPL27	PSMC3	0.876669403	6.10E-40
UCS	Cell metabolism gene	MRPL27	HMOX2	0.880222503	1.18E-40
UCS	Cell metabolism gene	MRPL27	TIMM10	0.883849492	2.08E-41
UCS	Cell metabolism gene	MRPL27	POLR2J	0.887044069	4.31E-42
UCS	Cell metabolism gene	MRPL27	ITPA	0.889172674	1.47E-42
UCS	Cell metabolism gene	MRPL27	ATP5G1	0.891630582	4.12E-43
UCS	Cell metabolism gene	MRPL27	DPM3	0.891921187	3.54E-43
UCS	Cell metabolism gene	MRPL27	PGLS	0.892808113	2.22E-43
UCS	Cell metabolism gene	MRPL27	POLR2H	0.892809125	2.22E-43
UCS	Cell metabolism gene	MRPL27	PSMC1	0.898638657	9.24E-45
UCS	Cell metabolism gene	MRPL27	PSMD4	0.900669048	2.92E-45
UCS	Cell metabolism gene	MRPL27	TOMM40	0.901489794	1.82E-45
UCS	Cell metabolism gene	MRPL27	APRT	0.902425102	1.06E-45
UCS	Cell metabolism gene	MRPL27	SNRPD2	0.905722726	1.48E-46
UCS	Cell metabolism gene	MRPL27	ACOT8	0.907271094	5.76E-47
UCS	Cell metabolism gene	MRPL27	PSMB7	0.911745227	3.40E-48
UCS	Cell metabolism gene	MRPL27	TIMM8B	0.916620995	1.30E-49
UCS	Cell metabolism gene	MRPL27	MTX1	0.918548882	3.39E-50
UCS	Cell metabolism gene	MRPL27	EXOSC4	0.919434671	1.81E-50
UCS	Cell metabolism gene	MRPL27	TIMM13	0.920364826	9.25E-51
UCS	Cell metabolism gene	MRPL27	DPM2	0.924053962	6.00E-52
UCS	Cell metabolism gene	MRPL27	PSMC5	0.935650857	4.09E-56
UCS	Cell metabolism gene	MRPL27	PSMB3	0.936555595	1.80E-56
UCS	Cell metabolism gene	MRPL27	TIMM50	0.945903937	1.67E-60
UCS	Cell metabolism gene	MRPL27	POLR2I	0.950296106	1.18E-62
UCS	CGC	MRPL27	SDHAF2	0.824384445	1.92E-31
UCS	CGC	MRPL27	MAP2K2	0.826049187	1.15E-31
UCS	CGC	MRPL27	MGMT	0.843327593	3.71E-34
UCS	CGC	MRPL27	RBM10	0.844093138	2.83E-34
UCS	CGC	MRPL27	COX6C	0.847975241	7.05E-35
UCS	CGC	MRPL27	TFPT	0.85755061	1.92E-36
UCS	CGC	MRPL27	ASPSCR1	0.88917742	1.46E-42
UCS	Epifactor	MRPL27	ZGPAT	0.818168447	1.27E-30
UCS	Epifactor	MRPL27	NOC2L	0.826322288	1.05E-31
UCS	Epifactor	MRPL27	PELP1	0.826581072	9.70E-32
UCS	Epifactor	MRPL27	CDK5	0.827993091	6.21E-32
UCS	Epifactor	MRPL27	C17orf49	0.834053899	8.74E-33
UCS	Epifactor	MRPL27	PRMT1	0.835139062	6.10E-33
UCS	Epifactor	MRPL27	MBD3	0.840203188	1.10E-33
UCS	Epifactor	MRPL27	CCDC101	0.8406539	9.42E-34
UCS	Epifactor	MRPL27	PAF1	0.844657466	2.32E-34
UCS	Epifactor	MRPL27	EXOSC5	0.845242136	1.89E-34
UCS	Epifactor	MRPL27	PPP4C	0.847037872	9.90E-35
UCS	Epifactor	MRPL27	RUVBL2	0.849044244	4.77E-35
UCS	Epifactor	MRPL27	FBL	0.855414082	4.39E-36
UCS	Epifactor	MRPL27	TFPT	0.85755061	1.92E-36
UCS	Epifactor	MRPL27	LAS1L	0.860969558	4.97E-37
UCS	Epifactor	MRPL27	INO80E	0.867766413	3.03E-38
UCS	Epifactor	MRPL27	TAF10	0.876039722	8.12E-40
UCS	Epifactor	MRPL27	BRMS1	0.902352186	1.10E-45
UCS	Epifactor	MRPL27	SIRT6	0.916318013	1.60E-49
UCS	Epifactor	MRPL27	ZNHIT1	0.917250267	8.41E-50
UCS	Epifactor	MRPL27	EXOSC4	0.919434671	1.81E-50
UCS	Epifactor	MRPL27	PRPF31	0.93093144	2.48E-54
UCS	IUPHAR	MRPL27	EGLN2	0.80480456	5.86E-29
UCS	IUPHAR	MRPL27	SLC25A39	0.814790096	3.45E-30
UCS	IUPHAR	MRPL27	SLC39A3	0.814890453	3.35E-30
UCS	IUPHAR	MRPL27	MAP2K2	0.826049187	1.15E-31
UCS	IUPHAR	MRPL27	PPIA	0.826207228	1.09E-31
UCS	IUPHAR	MRPL27	CDK5	0.827993091	6.21E-32
UCS	IUPHAR	MRPL27	FKBP1A	0.829993585	3.28E-32
UCS	IUPHAR	MRPL27	MPDU1	0.831823472	1.81E-32
UCS	IUPHAR	MRPL27	PRMT1	0.835139062	6.10E-33
UCS	IUPHAR	MRPL27	MMP24	0.839410815	1.44E-33
UCS	IUPHAR	MRPL27	SIRT3	0.839551594	1.38E-33
UCS	IUPHAR	MRPL27	PHKG2	0.853122023	1.05E-35
UCS	IUPHAR	MRPL27	SLC27A5	0.854195085	6.99E-36
UCS	IUPHAR	MRPL27	MVD	0.855903501	3.63E-36
UCS	IUPHAR	MRPL27	PTGES2	0.857662024	1.84E-36
UCS	IUPHAR	MRPL27	PSMB6	0.858951457	1.11E-36
UCS	IUPHAR	MRPL27	PSMB1	0.871327685	6.58E-39
UCS	IUPHAR	MRPL27	HMOX2	0.880222503	1.18E-40
UCS	IUPHAR	MRPL27	ATP6V0B	0.891959859	3.47E-43
UCS	IUPHAR	MRPL27	SIRT6	0.916318013	1.60E-49
UCS	Kinase	MRPL27	FASTK	0.823945158	2.21E-31
UCS	Kinase	MRPL27	MAP2K2	0.826049187	1.15E-31
UCS	Kinase	MRPL27	CDK5	0.827993091	6.21E-32
UCS	Kinase	MRPL27	PHKG2	0.853122023	1.05E-35
UCS	TF	MRPL27	ZNF668	0.805266017	5.16E-29
UCS	TF	MRPL27	ZNF580	0.811692673	8.46E-30
UCS	TF	MRPL27	ZGPAT	0.818168447	1.27E-30
UCS	TF	MRPL27	CENPB	0.821284304	4.99E-31
UCS	TF	MRPL27	REXO4	0.821634671	4.48E-31
UCS	TF	MRPL27	THAP3	0.830405753	2.87E-32
UCS	TF	MRPL27	ZNF511	0.831458047	2.04E-32
UCS	TF	MRPL27	DRAP1	0.835833232	4.84E-33
UCS	TF	MRPL27	MBD3	0.840203188	1.10E-33
UCS	TF	MRPL27	ZNF428	0.840859523	8.78E-34
UCS	TF	MRPL27	GLI4	0.841639216	6.70E-34
UCS	TF	MRPL27	THAP7	0.847270273	9.10E-35
UCS	TF	MRPL27	ZNF524	0.851326355	2.06E-35
UCS	TF	MRPL27	ZNF688	0.851352834	2.04E-35
UCS	TF	MRPL27	ZNF581	0.863131574	2.07E-37
UCS	TF	MRPL27	ZNF32	0.871635162	5.75E-39
UCS	TF	MRPL27	ZNF787	0.917942162	5.19E-50
UCS	TSG	MRPL27	TUSC2	0.800673596	1.80E-28
UCS	TSG	MRPL27	PYCARD	0.805177353	5.29E-29
UCS	TSG	MRPL27	ZNF668	0.805266017	5.16E-29
UCS	TSG	MRPL27	GSTP1	0.806369966	3.80E-29
UCS	TSG	MRPL27	NME1	0.82999763	3.27E-32
UCS	TSG	MRPL27	MAD1L1	0.837184609	3.08E-33
UCS	TSG	MRPL27	SIRT3	0.839551594	1.38E-33
UCS	TSG	MRPL27	PARK7	0.843201322	3.88E-34
UCS	TSG	MRPL27	STUB1	0.844428131	2.52E-34
UCS	TSG	MRPL27	GABARAP	0.852161101	1.51E-35
UCS	TSG	MRPL27	NPRL2	0.86801116	2.73E-38
UCS	TSG	MRPL27	PHB	0.871121759	7.20E-39
UCS	TSG	MRPL27	TSSC4	0.89761618	1.64E-44
UCS	TSG	MRPL27	BRMS1	0.902352186	1.10E-45
UCS	TSG	MRPL27	SIRT6	0.916318013	1.60E-49
UCS	TSG	MRPL27	GADD45GIP1	0.957565596	1.11E-66
UVM	Cell metabolism gene	MRPL27	PSMB3	0.80314382	3.19E-19

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
BRCA	MRPL27	MRPL32	-3.7979134181794	0.000134327661287861
STAD	MRPL27	MRPL15	-2.15546608137429	0.000334546435624361
KIRC	MRPL27	MRPL11	-1.04966837625557	0.000354478033746394
LIHC	MRPL27	MRPL13	1.54402472107614	0.000655351190157038
KIRC	MRPL27	MRPL46	-7.36081421944909	0.0011460554764592
LUAD	MRPL27	MRPL32	-2.1966239418264	0.00121089428940613
KIRP	MRPL27	MRPL46	-7.17671685013906	0.00123529229313135
CHOL	MRPL27	MRPL3	-2.68429255990621	0.00390625
CHOL	MRPL27	MRPL46	-2.73791743817321	0.00390625
ESCA	MRPL27	MRPL3	-4.97897094908275	0.0048828125
COAD	MRPL27	MRPL15	1.17181689924568	0.00513318181037904
ESCA	MRPL27	MRPL13	-1.07746088474995	0.0068359375
ESCA	MRPL27	MRPL17	-1.18756178214998	0.009765625
HNSC	MRPL27	MRPL33	2.19438927194823	0.0104026354399593
LIHC	MRPL27	MRPL17	-1.06225729770915	0.0124123499319886
STAD	MRPL27	MRPL4	1.4393539135682	0.0279771662317216
KIRC	MRPL27	MRPL32	-2.79664327578899	0.0376051795400881
PRAD	MRPL27	MRPL11	1.12581653394628	1.15996224044503e-05
KICH	MRPL27	MRPL15	1.54522142310359	1.19209289550781e-07
STAD	MRPL27	MRPL17	-3.90880705449186	1.49570405483246e-06
KIRP	MRPL27	MRPL49	-2.36524030474784	1.53668224811554e-08
LUSC	MRPL27	MRPL15	-4.43702988385305	1.91594862886626e-08
KIRC	MRPL27	MRPL3	1.69955762234244	1.97132191719422e-08
LIHC	MRPL27	MRPL32	-1.20074144698753	2.24402029682138e-06
COAD	MRPL27	MRPL4	2.77705897514473	2.98023223876954e-07
THCA	MRPL27	MRPL49	-1.28871899028168	5.42468304941934e-06
BRCA	MRPL27	MRPL15	-3.82448964360727	5.49451113259074e-14
LUSC	MRPL27	MRPL17	-6.83409683292749	6.93230040561614e-07

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with MRPL27

UBC, ICT1, APP, FHL3, RPL13, ZNF22, MRPL28, RPL6, RPS8, MRPL4, HNRNPA1, MRPL39, MRPL37, MRPS30, MRPL47, CDK2, HNRNPU, KIF11, MRPL50, THOC2, MRPL9, Gspt1, Elavl1, Max, Rab5c, Smc1a, Rfx5, FOXB1, MRPL10, MRPL42, MRPL41, MRPL35, ZNF274, PDGFB, MRPL12, KBTBD7, RPL7, RPL18, ATP1A1, GTF2H4, LEO1, MAPKAP1, MED24, MRPL57, MRPS5, PSMB6, TAF2, TIMELESS, FBXO7, RNF4, DPF2, RECQL4, RPS6, MRM1, HSPD1, PDK1, TRMT61B, AURKAIP1, RC3H1, RC3H2, NFX1, ACAD9, AUH, C12orf65, C17orf80, C1QBP, C21orf33, C6orf203, MCUR1, CHCHD1, COX15, CS, DDX28, GFM1, HINT2, LRPPRC, CCDC109B, MDH2, METTL15, METTL17, MRPL11, MRPS12, MRPS26, MRRF, MTERF3, MTG1, MTG2, MTIF2, MTIF3, MTRF1, MTRF1L, NGRN, PMPCA, PMPCB, SLIRP, SSBP1, TACO1, TBRG4, TMEM70, TRUB2, TSFM, TUFM, VWA8, EXD2, HSCB, MRPL19, MRPL38, MRPL15, MRPL44, MRPL18, MRPL49, MRPL17, MRPS18A, MRPL21, TRA2A, SRSF10, MRPL13, TRA2B, NHP2, MRPL45, MRPL20, MRPL43, HIST1H1T, DDX58, FZR1, MRPL30, PRR3, RPL23AP32, RPL17, FTL, MSI1, YBX1, PIPSL, CBX6, RPS3A, LIN28A, NEIL1, MRPL2, SRSF3, RPL37, MRPL33, THAP3, ZZEF1, HIST1H2AB, RBMS2, MALSU1, MRPL53, GNL3, RPS9, MRPL51, MRPL52, MRPL23, CBWD7, YBX2, H1FNT, ACTL6B, RPLP0, MRPL46, RPL10, MRPL40, MRPL22, RPL19, HIST1H2AM, RBMS3, RPL13A, GADD45GIP1, MRPL54, MRPL24, ZNF185, RPS19, MRPL3, RPL35, MRPL48, MRPL55, MRPL1, RPS2, MRPL32, MRPL34, FAHD1, MRPL16, PCCB, PCCA, OXA1L, HIST1H2AE,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
MRPL27	STAD	chr17	48445469	48445469	A	C	Missense_Mutation	p.L144R	2
MRPL27	BLCA	chr17	48445522	48445522	G	C	Silent	p.L126L	2
MRPL27	STAD	chr17	48447421	48447421	C	T	Missense_Mutation	p.R71H	2
MRPL27	BRCA	chr17	48447871	48447871	G	A	Silent	p.S39	2
MRPL27	LIHC	chr17	48447866	48447866	T	-	Frame_Shift_Del	p.N41fs	2
MRPL27	UCEC	chr17	48445544	48445544	C	T	Missense_Mutation	p.R119K	2
MRPL27	UCEC	chr17	48447945	48447945	T	C	Missense_Mutation	p.T15A	2
MRPL27	BLCA	chr17	48445522	48445522	G	C	Silent		2
MRPL27	SKCM	chr17	48447414	48447414	G	A	Silent	p.F73F	2
MRPL27	STAD	chr17	48445636	48445636	A	G	Silent		2
MRPL27	HNSC	chr17	48447949	48447949	T	A	Splice_Site	p.V14_splice	1
MRPL27	LGG	chr17	48447454	48447454	T	C	Missense_Mutation	p.Y60C	1
MRPL27	LIHC	chr17	48447873	48447873	A	G	Missense_Mutation		1
MRPL27	STAD	chr17	48445636	48445636	A	G	Silent	p.C33C	1
MRPL27	CESC	chr17	48447381	48447381	G	A	Silent		1
MRPL27	UCEC	chr17	48445470	48445470	G	T	Missense_Mutation	p.L144M	1
MRPL27	CESC	chr17	48447382	48447382	G	A	Missense_Mutation		1
MRPL27	LUAD	chr17	48445530	48445530	C	A	Missense_Mutation	p.A69S	1
MRPL27	CESC	chr17	48447381	48447381	G	A	Silent	p.S84S	1
MRPL27	SARC	chr17	48445480	48445480	G	T	Silent		1
MRPL27	CESC	chr17	48447382	48447382	G	A	Missense_Mutation	p.S84F	1
MRPL27	SARC	chr17	48447914	48447914	G	T	Missense_Mutation		1
MRPL27	CESC	chr17	48447381	48447381	G	A	Silent	p.S84	1
MRPL27	SKCM	chr17	48447883	48447883	C	A	Silent	p.S35S	1
MRPL27	COAD	chr17	48445498	48445498	A	G	Silent	p.V134V	1
MRPL27	BLCA	chr17	48447889	48447889	C	A	Missense_Mutation		1
MRPL27	HNSC	chr17	48450508	48450508	C	T	Silent		1
MRPL27	BLCA	chr17	48445522	48445522	G	C	Silent	p.L71L	1
MRPL27	HNSC	chr17	48450508	48450508	C	T	Silent	p.L8L	1
MRPL27	STAD	chr17	48445636	48445636	A	G	Silent	p.C88C	1
MRPL27	BLCA	chr17	48447889	48447889	C	A	Missense_Mutation	p.K33N	1

Copy number variation (CNV) of MRPL27
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across MRPL27
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
35974	N/A	BF665678	HEATR5B	chr2	37227200	-	MRPL27	chr17	48450551	-
87554	N/A	T20101	MRPL27	chr17	48447940	+	CCDC150	chr2	197613494	+
88939	GBM	TCGA-06-0882-01A	MRPL27	chr17	48447393	-	EFCAB3	chr17	60455329	+
99292	BRCA	TCGA-A8-A092	MRPL27	chr17	48450491	-	TMEM99	chr17	38989366	+
99292	BRCA	TCGA-A8-A092-01A	MRPL27	chr17	48450492	-	TMEM99	chr17	38989367	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRP	MRPL27	0.0118606184941964	0.33
BRCA	MRPL27	0.0278198718138716	0.75

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	MRPL27	0.00111986321737594	0.036
LGG	MRPL27	7.18474364939049e-06	0.00024
LAML	MRPL27	0.00148479964263002	0.046

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source