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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: MRPL35 (NCBI Gene ID:51318)

Gene Summary

Gene Summary

Gene Information	Gene Name: MRPL35
	Gene ID: 51318
	Gene Symbol	MRPL35
	Gene ID	51318
	Gene Name	mitochondrial ribosomal protein L35
	Synonyms	L35mt\|MRP-L35
	Cytomap	2p11.2
	Type of Gene	protein-coding
	Description	39S ribosomal protein L35, mitochondrialmitochondrial large ribosomal subunit protein bL35m
	Modification date	20200313
	UniProtAcc	Q9NZE8

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
MRPL35	(733 - 1119.25]

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Translation Studies in PubMed

We searched PubMed using 'MRPL35[title] AND translation [title] AND human.'

Gene	Title	PMID
MRPL35	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000337109	86433228	86433418	Frame-shift
ENST00000337109	86434305	86434450	Frame-shift

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
LUAD	MRPL35	-1.31856904471006	2.4976782316193e-09
COAD	MRPL35	-1.76232528333129	2.98023223876954e-08
LUSC	MRPL35	-3.88921748745786	3.23227619897643e-09

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
BLCA	MRPL35	1	2	0.0424012552733514	0.173867948717949	0.350553404592241	-0.397397249016492	-0.116986742895572

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
KIRP	MRPL35	-0.050613866	0.012654005
UVM	MRPL35	0.138289142	0.023117977

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with MRPL35 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	Cell metabolism gene	MRPL35	ACO2	0.81292183	1.18E-11
UVM	Cell metabolism gene	MRPL35	SPTLC1	0.800840235	4.79E-19
UVM	Cell metabolism gene	MRPL35	GPD2	0.805206188	2.21E-19
UVM	Cell metabolism gene	MRPL35	RAP1B	0.808345966	1.25E-19
UVM	Cell metabolism gene	MRPL35	SAR1B	0.809553	1.00E-19
UVM	Cell metabolism gene	MRPL35	AZIN1	0.810297946	8.71E-20
UVM	Cell metabolism gene	MRPL35	HS2ST1	0.811570647	6.88E-20
UVM	Cell metabolism gene	MRPL35	TRAM1	0.812768368	5.49E-20
UVM	Cell metabolism gene	MRPL35	PAFAH1B1	0.815750545	3.12E-20
UVM	Cell metabolism gene	MRPL35	PSMC2	0.817639049	2.17E-20
UVM	Cell metabolism gene	MRPL35	DLAT	0.817908297	2.06E-20
UVM	Cell metabolism gene	MRPL35	CALM2	0.826359123	3.83E-21
UVM	Cell metabolism gene	MRPL35	SLC25A32	0.826571353	3.67E-21
UVM	Cell metabolism gene	MRPL35	GFPT1	0.827666678	2.93E-21
UVM	Cell metabolism gene	MRPL35	PITPNB	0.829166627	2.15E-21
UVM	Cell metabolism gene	MRPL35	PSMC6	0.833730469	8.18E-22
UVM	Cell metabolism gene	MRPL35	NUP50	0.834014497	7.70E-22
UVM	Cell metabolism gene	MRPL35	IMPA1	0.834227022	7.35E-22
UVM	Cell metabolism gene	MRPL35	LCLAT1	0.834928438	6.32E-22
UVM	Cell metabolism gene	MRPL35	LYPLA1	0.838175179	3.11E-22
UVM	Cell metabolism gene	MRPL35	PSMA4	0.843560824	9.25E-23
UVM	Cell metabolism gene	MRPL35	PSMD12	0.843568039	9.24E-23
UVM	Cell metabolism gene	MRPL35	MCEE	0.84865857	2.81E-23
UVM	Cell metabolism gene	MRPL35	TIMM17A	0.849357138	2.38E-23
UVM	Cell metabolism gene	MRPL35	TNPO1	0.856468975	4.16E-24
UVM	Cell metabolism gene	MRPL35	DLD	0.861089173	1.27E-24
UVM	Cell metabolism gene	MRPL35	TGS1	0.865298461	4.17E-25
UVM	Cell metabolism gene	MRPL35	MDH1	0.87019211	1.09E-25
UVM	Cell metabolism gene	MRPL35	PIK3C2A	0.871238886	8.08E-26
UVM	Cell metabolism gene	MRPL35	XPO1	0.875079929	2.67E-26
UVM	Cell metabolism gene	MRPL35	PSME4	0.8925988	1.04E-28
UVM	Cell metabolism gene	MRPL35	PSMD14	0.896596029	2.56E-29
UVM	CGC	MRPL35	EZH2	0.801890998	3.98E-19
UVM	CGC	MRPL35	PMS1	0.802983106	3.28E-19
UVM	CGC	MRPL35	CUL3	0.805562093	2.07E-19
UVM	CGC	MRPL35	MAP2K4	0.811033197	7.60E-20
UVM	CGC	MRPL35	TCF12	0.813264667	5.00E-20
UVM	CGC	MRPL35	RAD21	0.82454829	5.53E-21
UVM	CGC	MRPL35	FBXO11	0.826642304	3.61E-21
UVM	CGC	MRPL35	NBN	0.830540327	1.61E-21
UVM	CGC	MRPL35	ATM	0.833310039	8.95E-22
UVM	CGC	MRPL35	RABEP1	0.866340085	3.15E-25
UVM	CGC	MRPL35	XPO1	0.875079929	2.67E-26
UVM	Epifactor	MRPL35	EZH2	0.801890998	3.98E-19
UVM	Epifactor	MRPL35	TAF7	0.802940355	3.31E-19
UVM	Epifactor	MRPL35	UCHL5	0.804477534	2.51E-19
UVM	Epifactor	MRPL35	RAD54B	0.804779201	2.38E-19
UVM	Epifactor	MRPL35	CUL3	0.805562093	2.07E-19
UVM	Epifactor	MRPL35	TLK1	0.807179489	1.54E-19
UVM	Epifactor	MRPL35	MASTL	0.820609187	1.21E-20
UVM	Epifactor	MRPL35	HAT1	0.823650507	6.63E-21
UVM	Epifactor	MRPL35	TAF5	0.825479654	4.58E-21
UVM	Epifactor	MRPL35	AEBP2	0.826758012	3.53E-21
UVM	Epifactor	MRPL35	NBN	0.830540327	1.61E-21
UVM	Epifactor	MRPL35	PHF20L1	0.833309373	8.96E-22
UVM	Epifactor	MRPL35	ATM	0.833310039	8.95E-22
UVM	Epifactor	MRPL35	SMARCA5	0.835546341	5.53E-22
UVM	Epifactor	MRPL35	CBX3	0.83872941	2.75E-22
UVM	Epifactor	MRPL35	TAF2	0.843858847	8.64E-23
UVM	Epifactor	MRPL35	SMEK2	0.84418644	8.01E-23
UVM	IUPHAR	MRPL35	SPTLC1	0.800840235	4.79E-19
UVM	IUPHAR	MRPL35	EZH2	0.801890998	3.98E-19
UVM	IUPHAR	MRPL35	CSNK1A1	0.803556497	2.96E-19
UVM	IUPHAR	MRPL35	ADAM17	0.803921272	2.78E-19
UVM	IUPHAR	MRPL35	SLC30A6	0.805626806	2.05E-19
UVM	IUPHAR	MRPL35	TBK1	0.806973877	1.60E-19
UVM	IUPHAR	MRPL35	TLK1	0.807179489	1.54E-19
UVM	IUPHAR	MRPL35	NAPEPLD	0.80749818	1.46E-19
UVM	IUPHAR	MRPL35	RIOK2	0.81055053	8.31E-20
UVM	IUPHAR	MRPL35	MAP2K4	0.811033197	7.60E-20
UVM	IUPHAR	MRPL35	MARK3	0.811253293	7.30E-20
UVM	IUPHAR	MRPL35	ATP6V1H	0.811293187	7.24E-20
UVM	IUPHAR	MRPL35	ATP2B1	0.813365855	4.91E-20
UVM	IUPHAR	MRPL35	MAPK6	0.813398563	4.88E-20
UVM	IUPHAR	MRPL35	TMEM165	0.813687247	4.62E-20
UVM	IUPHAR	MRPL35	MASTL	0.820609187	1.21E-20
UVM	IUPHAR	MRPL35	HAT1	0.823650507	6.63E-21
UVM	IUPHAR	MRPL35	STK3	0.825091872	4.96E-21
UVM	IUPHAR	MRPL35	SLC25A32	0.826571353	3.67E-21
UVM	IUPHAR	MRPL35	FBXO11	0.826642304	3.61E-21
UVM	IUPHAR	MRPL35	IDE	0.826964682	3.38E-21
UVM	IUPHAR	MRPL35	ABCB10	0.831797453	1.24E-21
UVM	IUPHAR	MRPL35	SRPK2	0.831830954	1.23E-21
UVM	IUPHAR	MRPL35	ATM	0.833310039	8.95E-22
UVM	IUPHAR	MRPL35	CYP51A1	0.83344212	8.70E-22
UVM	IUPHAR	MRPL35	IMPA1	0.834227022	7.35E-22
UVM	IUPHAR	MRPL35	VRK2	0.837079459	3.96E-22
UVM	IUPHAR	MRPL35	MAP4K3	0.849297879	2.42E-23
UVM	IUPHAR	MRPL35	PRMT3	0.856310879	4.33E-24
UVM	IUPHAR	MRPL35	ATP6V1C1	0.857740878	3.02E-24
UVM	IUPHAR	MRPL35	PIK3C2A	0.871238886	8.08E-26
UVM	IUPHAR	MRPL35	XPO1	0.875079929	2.67E-26
UVM	IUPHAR	MRPL35	PSMD14	0.896596029	2.56E-29
UVM	Kinase	MRPL35	CSNK1A1	0.803556497	2.96E-19
UVM	Kinase	MRPL35	TBK1	0.806973877	1.60E-19
UVM	Kinase	MRPL35	TLK1	0.807179489	1.54E-19
UVM	Kinase	MRPL35	RIOK2	0.81055053	8.31E-20
UVM	Kinase	MRPL35	MAP2K4	0.811033197	7.60E-20
UVM	Kinase	MRPL35	MARK3	0.811253293	7.30E-20
UVM	Kinase	MRPL35	MAPK6	0.813398563	4.88E-20
UVM	Kinase	MRPL35	MASTL	0.820609187	1.21E-20
UVM	Kinase	MRPL35	STK3	0.825091872	4.96E-21
UVM	Kinase	MRPL35	SRPK2	0.831830954	1.23E-21
UVM	Kinase	MRPL35	ATM	0.833310039	8.95E-22
UVM	Kinase	MRPL35	VRK2	0.837079459	3.96E-22
UVM	Kinase	MRPL35	MAP4K3	0.849297879	2.42E-23
UVM	TF	MRPL35	TCF12	0.813264667	5.00E-20
UVM	TF	MRPL35	ZNF451	0.818623031	1.79E-20
UVM	TF	MRPL35	E2F5	0.818793036	1.73E-20
UVM	TF	MRPL35	AEBP2	0.826758012	3.53E-21
UVM	TF	MRPL35	CEBPZ	0.840644848	1.79E-22
UVM	TF	MRPL35	TERF1	0.852228877	1.19E-23
UVM	TF	MRPL35	PRMT3	0.856310879	4.33E-24
UVM	TSG	MRPL35	EZH2	0.801890998	3.98E-19
UVM	TSG	MRPL35	CSNK1A1	0.803556497	2.96E-19
UVM	TSG	MRPL35	INTS6	0.804380964	2.56E-19
UVM	TSG	MRPL35	NAPEPLD	0.80749818	1.46E-19
UVM	TSG	MRPL35	MAP2K4	0.811033197	7.60E-20
UVM	TSG	MRPL35	MLH3	0.812078911	6.25E-20
UVM	TSG	MRPL35	PAFAH1B1	0.815750545	3.12E-20
UVM	TSG	MRPL35	RINT1	0.818162741	1.96E-20
UVM	TSG	MRPL35	PPP2R5C	0.825285175	4.77E-21
UVM	TSG	MRPL35	NBN	0.830540327	1.61E-21
UVM	TSG	MRPL35	ATM	0.833310039	8.95E-22

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
STAD	MRPL35	MRPL15	-2.15546608137429	0.000334546435624361
LIHC	MRPL35	MRPL13	1.54402472107614	0.000655351190157038
LUSC	MRPL35	MRPL39	-3.50411737429004	0.000985010025625636
ESCA	MRPL35	MRPL47	-2.26373711796715	0.001953125
BLCA	MRPL35	MRPL27	-4.19270554058168	0.00202178955078125
ESCA	MRPL35	MRPL48	-2.17664297194246	0.0029296875
LUAD	MRPL35	MRPL48	-1.10341092084552	0.00317944105654513
CHOL	MRPL35	MRPL2	-1.49926301466752	0.00390625
BLCA	MRPL35	MRPL39	1.69896851960452	0.00391769409179688
LUAD	MRPL35	MRPL39	-1.1049452981592	0.00471395891927286
COAD	MRPL35	MRPL15	1.17181689924568	0.00513318181037904
ESCA	MRPL35	MRPL13	-1.07746088474995	0.0068359375
KIRP	MRPL35	MRPL50	1.73501379972723	0.00733334058895707
COAD	MRPL35	MRPL47	-2.29582381838246	0.00863465666770936
COAD	MRPL35	MRPL48	1.05473904000693	0.0101850330829621
STAD	MRPL35	MRPL47	-1.4008685687155	0.0118026207201183
PRAD	MRPL35	MRPL30	-4.12312923501503	0.014115364517111
LUAD	MRPL35	MRPL50	-2.00209640961088	0.0197825515973911
STAD	MRPL35	MRPL4	1.4393539135682	0.0279771662317216
COAD	MRPL35	MRPL39	-1.15285953291756	0.0357243716716767
LIHC	MRPL35	MRPL47	-6.59586850948538	0.0416658979324166
BLCA	MRPL35	MRPL2	-3.29210657477178	0.0445594787597656
HNSC	MRPL35	MRPL30	-1.59550877405286	0.0462444565380338
KIRC	MRPL35	MRPL47	1.74758475364701	1.00533732476669e-06
LUAD	MRPL35	MRPL2	-1.26727646741024	1.07341296213058e-06
BRCA	MRPL35	MRPL27	-1.5584165725499	1.16393956539382e-08
KICH	MRPL35	MRPL15	1.54522142310359	1.19209289550781e-07
LUAD	MRPL35	MRPL30	-2.63663981132176	1.27909593349618e-09
LUSC	MRPL35	MRPL15	-4.43702988385305	1.91594862886626e-08
COAD	MRPL35	MRPL4	2.77705897514473	2.98023223876954e-07
LUAD	MRPL35	MRPL27	-1.39404329671842	3.44055922076328e-05
LUSC	MRPL35	MRPL27	-1.81809468729316	3.90393047420304e-06
LIHC	MRPL35	MRPL39	-1.65461683386216	3.95799979560965e-08
BRCA	MRPL35	MRPL48	-1.11598766368451	3.97642668731928e-05
BRCA	MRPL35	MRPL15	-3.82448964360727	5.49451113259074e-14
LUSC	MRPL35	MRPL2	-2.66710222706783	7.24218086307245e-08
LUAD	MRPL35	MRPL47	-1.74990909879567	9.53955602455483e-07

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with MRPL35

APP, MRPL4, MRPL39, MRPS30, MRPL47, RACGAP1, MRPL50, MRPL9, MRPL1, Kif4, C6orf203, MRPL10, MRPL42, MRPL28, MRPL12, MRPL30, MRS2, VPRBP, MRPL13, UBE2O, MRPL38, MRPL41, MRPL45, MRPL40, MRPL27, MALSU1, METAP2, MRPL15, MRPL34, HNRNPA1, NAP1L1, IPO5, NAP1L4, MKI67, MRPS18A, RANBP6, MRPL48, MRPL20, MRPL55, MRPL49, LUC7L, MRPL2, MRPL3, TEX11, RHBDD2, HSCB, C12orf65, C1QBP, ICT1, MTRF1, TRUB2, ACACA, PIPSL, SRSF3, GADD45GIP1, ABT1, HNRNPU, H1FNT, RPL37, RPL17, RBMS2, MRPL44, PRR3, MRPL53, MRPL23, MRPL52, MRPL33, FTL, MRPL51, MRPL18, MRPL16, SRSF7, RBMS3, MRPL46, ZNF574, RPL4, HIST1H1T, RPL35, RPL23A, FAHD1, NIFK, H2AFX, ZC3H3, RPS8, IPO7, MRPL37, NEIL1, RPL10, RPL36AL, RPL19, ZFYVE1, WIPI1,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
MRPL35	UCEC	chr2	86434439	86434439	G	A	Missense_Mutation	p.V123M	3
MRPL35	CESC	chr2	86433240	86433240	C	T	Missense_Mutation		3
MRPL35	BLCA	chr2	86434448	86434448	A	C	Missense_Mutation	p.K126Q	3
MRPL35	SKCM	chr2	86434390	86434390	C	G	Silent	p.T106T	3
MRPL35	BLCA	chr2	86437695	86437695	C	T	Silent	p.L157L	3
MRPL35	BRCA	chr2	86434315	86434315	C	T	Silent	p.P81	2
MRPL35	UCEC	chr2	86426624	86426624	C	T	Missense_Mutation	p.S4F	2
MRPL35	UCEC	chr2	86437651	86437651	C	T	Nonsense_Mutation	p.R143*	2
MRPL35	CESC	chr2	86426645	86426645	G	A	Missense_Mutation	p.R11K	2
MRPL35	UCEC	chr2	86437652	86437652	G	A	Missense_Mutation	p.R143Q	2
MRPL35	BLCA	chr2	86437695	86437695	C	T	Silent		2
MRPL35	CHOL	chr2	86437740	86437740	C	T	Silent	p.Y172Y	2
MRPL35	UCEC	chr2	86437660	86437660	G	A	Missense_Mutation	p.E146K	2
MRPL35	SARC	chr2	86437709	86437709	C	T	Missense_Mutation		2
MRPL35	COAD	chr2	86434315	86434315	C	T	Silent	p.P81P	2
MRPL35	SARC	chr2	86437709	86437709	C	T	Missense_Mutation	p.T162M	2
MRPL35	BLCA	chr2	86434368	86434368	C	T	Missense_Mutation	p.A99V	2
MRPL35	STAD	chr2	86437712	86437712	C	T	Missense_Mutation	p.T163M	2
MRPL35	HNSC	chr2	86433353	86433353	C	T	Silent	p.S56S	2
MRPL35	LUAD	chr2	86433312	86433312	A	C	Missense_Mutation	p.T43P	2
MRPL35	LGG	chr2	86434352	86434352	C	-	Frame_Shift_Del	p.L94fs	1
MRPL35	LUAD	chr2	86437737	86437737	G	T	Missense_Mutation	p.W171C	1
MRPL35	LIHC	chr2	86434329	86434329	T	C	Missense_Mutation		1
MRPL35	PAAD	chr2	86433365	86433366	-	A	Frame_Shift_Ins	p.H61fs	1
MRPL35	LIHC	chr2	86433255	86433255	G	T	Missense_Mutation	p.A24S	1
MRPL35	READ	chr2	86433412	86433412	T	G	Missense_Mutation	p.L76R	1
MRPL35	CESC	chr2	86426645	86426645	G	A	Missense_Mutation		1
MRPL35	LIHC	chr2	86434440	86434440	T	-	Frame_Shift_Del	p.V123X	1
MRPL35	BLCA	chr2	86434448	86434448	A	C	Missense_Mutation		1
MRPL35	READ	chr2	86437729	86437729	C	T	Nonsense_Mutation	p.R169X	1
MRPL35	LIHC	chr2	86434434	86434434	T	-	Frame_Shift_Del	p.L121fs	1
MRPL35	READ	chr2	86434405	86434405	C	T	Silent	p.I111I	1
MRPL35	LIHC	chr2	86437678	86437678	A	-	Frame_Shift_Del	p.K152fs	1
MRPL35	BLCA	chr2	86434368	86434368	C	T	Missense_Mutation		1
MRPL35	COAD	chr2	86433240	86433240	C	T	Missense_Mutation	p.P19S	1
MRPL35	LIHC	chr2	86433393	86433393	G	-	Frame_Shift_Del	p.G70fs	1
MRPL35	BLCA	chr2	86433233	86433233	C	G	Missense_Mutation		1
MRPL35	SARC	chr2	86434377	86434377	G	T	Missense_Mutation		1
MRPL35	LIHC	chr2	86434361	86434361	T	-	Frame_Shift_Del	p.F97fs	1
MRPL35	COAD	chr2	86437614	86437614	G	T	Missense_Mutation	p.K130N	1
MRPL35	LIHC	chr2	86437702	86437702	A	-	Frame_Shift_Del	p.K160fs	1
MRPL35	HNSC	chr2	86433353	86433353	C	T	Silent		1
MRPL35	LUAD	chr2	86433236	86433236	A	T	Silent	p.L17L	1
MRPL35	BLCA	chr2	86433233	86433233	C	G	Missense_Mutation	p.I16M	1
MRPL35	STAD	chr2	86433347	86433347	T	C	Silent	p.V54V	1

Copy number variation (CNV) of MRPL35
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across MRPL35
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
85609	LUAD	TCGA-44-4112-01A	KDM3A	chr2	86669356	-	MRPL35	chr2	86433229	+
101431	STAD	TCGA-HU-A4GY	MRPL35	chr2	86437736	+	ADK	chr10	76349039	+
101647	ESCA	TCGA-VR-A8EO	MRPL35	chr2	86437736	+	AKT2	chr19	40761176	-
94197	LUSC	TCGA-18-3414-01A	MRPL35	chr2	86434450	+	CTNNA2	chr2	80772107	+
81134	N/A	EC564002	MRPL35	chr2	86434451	+	ITGB7	chr12	53592881	-
97116	N/A	BQ359421	MRPL35	chr2	86439807	-	MLLT6	chr17	36872913	+
88182	N/A	AA226331	MRPL35	chr2	86431562	+	NAAA	chr4	76844186	+
101576	N/A	BQ426050	MRPL35	chr2	86437651	+	PEPD	chr19	33877937	-
73001	N/A	FN170217	MRPL35	chr2	86437601	-	PLXNA4	chr7	131808030	+
87059	N/A	AA573035	MRPL35	chr2	86431560	+	RPS13	chr11	17095936	+
102813	STAD	TCGA-IN-7808-01A	MRPL35	chr2	86437736	+	TMEM254	chr10	81850553	+
85621	N/A	CB048624	SPATS2	chr12	49848241	-	MRPL35	chr2	86439959	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
SARC	MRPL35	0.0167601439575946	0.47
HNSC	MRPL35	0.0203912036156261	0.55
LIHC	MRPL35	0.0397800962889656	1

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LIHC	MRPL35	0.0267765226487626	0.8
KIRC	MRPL35	0.0224057310091096	0.69
BRCA	MRPL35	0.000571914500918028	0.019
PRAD	MRPL35	0.00815008545447515	0.26
PAAD	MRPL35	0.0451367739523495	1

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source