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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RWDD1 (NCBI Gene ID:51389)

Gene Summary

Gene Summary

Gene Information	Gene Name: RWDD1
	Gene ID: 51389
	Gene Symbol	RWDD1
	Gene ID	51389
	Gene Name	RWD domain containing 1
	Synonyms	CGI-24\|PTD013
	Cytomap	6q22.1
	Type of Gene	protein-coding
	Description	RWD domain-containing protein 1DRG family-regulatory protein 2
	Modification date	20200313
	UniProtAcc	Q9H446

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
RWDD1	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'RWDD1[title] AND translation [title] AND human.'

Gene	Title	PMID
RWDD1	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000466444	116905889	116906020	Frame-shift
ENST00000466444	116912050	116912113	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000466444	116912050	116912113	5539	764	826	243	182	203

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
Q9H446	182	203	2	243	Chain	ID=PRO_0000097540;Note=RWD domain-containing protein 1
Q9H446	182	203	142	197	Region	Note=Interaction with DRG2;Ontology_term=ECO:0000250;evidence=ECO:0000250

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
ESCA	RWDD1	1.43074573953025	0.009765625
PRAD	RWDD1	-1.37015889011473	0.0291755363147523
BRCA	RWDD1	-1.13785288766259	3.18183978181012e-05

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
CHOL	RWDD1	hsa-miR-34a-5p	69	0.402108036890646	0.00653231377451465

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type

Gene

Coefficient

Pvalue

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RWDD1 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
DLBC	Cell metabolism gene	RWDD1	PSMB1	0.84170615	6.72E-14
DLBC	Epifactor	RWDD1	DMAP1	0.807778608	3.96E-12
DLBC	IUPHAR	RWDD1	PSMB1	0.84170615	6.72E-14
DLBC	TF	RWDD1	THAP3	0.804323303	5.74E-12
THYM	Cell metabolism gene	RWDD1	PSMD13	0.801638689	1.39E-28
THYM	Cell metabolism gene	RWDD1	PFDN6	0.804360253	6.62E-29
THYM	Cell metabolism gene	RWDD1	SNRPD2	0.807089269	3.11E-29
THYM	Cell metabolism gene	RWDD1	PSMB7	0.808991771	1.82E-29
THYM	Cell metabolism gene	RWDD1	ZNRD1	0.812658126	6.41E-30
THYM	Cell metabolism gene	RWDD1	SEC61B	0.819114455	9.60E-31
THYM	Cell metabolism gene	RWDD1	LSM2	0.845572272	1.68E-34
THYM	Cell metabolism gene	RWDD1	UROD	0.849744998	3.69E-35
THYM	Cell metabolism gene	RWDD1	PSMB1	0.883227808	2.81E-41
THYM	CGC	RWDD1	TFPT	0.818988696	9.97E-31
THYM	Epifactor	RWDD1	ZNHIT1	0.811325334	9.40E-30
THYM	Epifactor	RWDD1	TFPT	0.818988696	9.97E-31
THYM	Epifactor	RWDD1	DMAP1	0.821035428	5.38E-31
THYM	Epifactor	RWDD1	PRMT7	0.826655132	9.47E-32
THYM	IUPHAR	RWDD1	PRMT7	0.826655132	9.47E-32
THYM	IUPHAR	RWDD1	MMP24	0.830996561	2.37E-32
THYM	IUPHAR	RWDD1	CSNK2B	0.87839678	2.76E-40
THYM	IUPHAR	RWDD1	PSMB1	0.883227808	2.81E-41
THYM	TF	RWDD1	ZNF444	0.829523	3.81E-32
THYM	TF	RWDD1	ZNF428	0.833788383	9.54E-33
THYM	TF	RWDD1	DRAP1	0.842461669	5.03E-34
THYM	TF	RWDD1	THYN1	0.854992471	5.15E-36
THYM	TSG	RWDD1	HTRA2	0.80991294	1.41E-29
THYM	TSG	RWDD1	GLTSCR2	0.812208872	7.29E-30
THYM	TSG	RWDD1	AIF1	0.820634575	6.07E-31
THYM	TSG	RWDD1	GNB2L1	0.834623616	7.24E-33
UCS	Cell metabolism gene	RWDD1	PSMD13	0.801638689	1.39E-28
UCS	Cell metabolism gene	RWDD1	PFDN6	0.804360253	6.62E-29
UCS	Cell metabolism gene	RWDD1	SNRPD2	0.807089269	3.11E-29
UCS	Cell metabolism gene	RWDD1	PSMB7	0.808991771	1.82E-29
UCS	Cell metabolism gene	RWDD1	ZNRD1	0.812658126	6.41E-30
UCS	Cell metabolism gene	RWDD1	SEC61B	0.819114455	9.60E-31
UCS	Cell metabolism gene	RWDD1	LSM2	0.845572272	1.68E-34
UCS	Cell metabolism gene	RWDD1	UROD	0.849744998	3.69E-35
UCS	Cell metabolism gene	RWDD1	PSMB1	0.883227808	2.81E-41
UCS	CGC	RWDD1	TFPT	0.818988696	9.97E-31
UCS	Epifactor	RWDD1	ZNHIT1	0.811325334	9.40E-30
UCS	Epifactor	RWDD1	TFPT	0.818988696	9.97E-31
UCS	Epifactor	RWDD1	DMAP1	0.821035428	5.38E-31
UCS	Epifactor	RWDD1	PRMT7	0.826655132	9.47E-32
UCS	IUPHAR	RWDD1	PRMT7	0.826655132	9.47E-32
UCS	IUPHAR	RWDD1	MMP24	0.830996561	2.37E-32
UCS	IUPHAR	RWDD1	CSNK2B	0.87839678	2.76E-40
UCS	IUPHAR	RWDD1	PSMB1	0.883227808	2.81E-41
UCS	TF	RWDD1	ZNF444	0.829523	3.81E-32
UCS	TF	RWDD1	ZNF428	0.833788383	9.54E-33
UCS	TF	RWDD1	DRAP1	0.842461669	5.03E-34
UCS	TF	RWDD1	THYN1	0.854992471	5.15E-36
UCS	TSG	RWDD1	HTRA2	0.80991294	1.41E-29
UCS	TSG	RWDD1	GLTSCR2	0.812208872	7.29E-30
UCS	TSG	RWDD1	AIF1	0.820634575	6.07E-31
UCS	TSG	RWDD1	GNB2L1	0.834623616	7.24E-33
UVM	TF	RWDD1	HSF2	0.806441911	1.77E-19

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
LUSC	RWDD1	RWDD2A	2.43528772928372	0.000201938028703404
LUAD	RWDD1	DRG1	-1.38896782665224	0.00022838170846318
STAD	RWDD1	PFDN5	1.59545112800561	0.000234263017773628
PRAD	RWDD1	GCN1L1	-7.54173196078564	0.000376184722398862
KIRC	RWDD1	GCN1L1	1.52944128066025	0.00150654978717842
STAD	RWDD1	ZC3H15	-1.04968618173197	0.00733334058895707
ESCA	RWDD1	EBNA1BP2	-1.99200120964051	0.009765625
KIRC	RWDD1	DRG1	-4.16008421708878	0.0152218459760014
COAD	RWDD1	RWDD2A	-2.46138283574863	0.0189773440361023
CHOL	RWDD1	DRG1	-2.74036943476079	0.01953125
BLCA	RWDD1	ZC3H15	1.07480871713981	0.0258216857910156
BRCA	RWDD1	EBNA1BP2	-6.67569914915961	1.14170217447768e-18
LIHC	RWDD1	GCN1L1	-1.50546993282376	2.24402029682138e-06
LUAD	RWDD1	EBNA1BP2	-9.21983506279797	4.60205959480617e-09
BRCA	RWDD1	DRG2	1.55172876221269	5.83844264602967e-05
LUAD	RWDD1	GCN1L1	-3.11494072871482	5.86248556550202e-05
THCA	RWDD1	RWDD2A	-3.01385981083144	6.03921940186051e-06
KICH	RWDD1	EBNA1BP2	2.41205887435955	8.16583633422851e-06
HNSC	RWDD1	PFDN5	2.51293680628916	8.21439698484029e-08
LIHC	RWDD1	EBNA1BP2	-9.24832970918865	9.87002535347663e-07

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RWDD1

DRG1, NUDT18, DRG2, XPO1, EGFR, CD74, MAP3K14, P2RY6, DNAJC2, HSPA14, DNAJC1, EP300,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RWDD1	LIHC	chr6	116912097	116912097	C	-	Frame_Shift_Del	p.I198fs	3
RWDD1	BLCA	chr6	116914146	116914146	G	C	Missense_Mutation	p.G205A	2
RWDD1	LIHC	chr6	116901493	116901493	G	A	Missense_Mutation		2
RWDD1	BLCA	chr6	116892761	116892761	G	A	Missense_Mutation	p.E6K	2
RWDD1	BLCA	chr6	116914217	116914217	G	A	Missense_Mutation	p.D229N	2
RWDD1	UCEC	chr6	116910017	116910017	C	A	Missense_Mutation	p.L95I	2
RWDD1	UCEC	chr6	116910146	116910146	A	T	Nonsense_Mutation	p.K138*	2
RWDD1	UCEC	chr6	116914255	116914255	A	C	Silent	p.S241	2
RWDD1	OV	chr6	116914220	116914220	C	A	Missense_Mutation	p.P230T	1
RWDD1	BLCA	chr6	116892761	116892761	G	A	Missense_Mutation		1
RWDD1	SKCM	chr6	116914170	116914170	C	T	Missense_Mutation	p.S213F	1
RWDD1	HNSC	chr6	116910017	116910017	C	G	Missense_Mutation		1
RWDD1	OV	chr6	116914221	116914221	C	A	Missense_Mutation	p.P230Q	1
RWDD1	BLCA	chr6	116914217	116914217	G	A	Missense_Mutation		1
RWDD1	SKCM	chr6	116892810	116892810	C	T	Missense_Mutation	p.S22F	1
RWDD1	HNSC	chr6	116910017	116910017	C	G	Missense_Mutation	p.L95V	1
RWDD1	SARC	chr6	116912049	116912049	A	T	Splice_Site		1
RWDD1	BLCA	chr6	116914254	116914254	C	T	Missense_Mutation		1
RWDD1	STAD	chr6	116912056	116912056	C	A	Missense_Mutation	p.Q185K	1
RWDD1	LIHC	chr6	116901485	116901485	C	A	Missense_Mutation		1
RWDD1	SKCM	chr6	116905895	116905895	C	T	Nonsense_Mutation	p.Q49X	1
RWDD1	STAD	chr6	116911490	116911490	A	C	Missense_Mutation	p.K157T	1
RWDD1	SKCM	chr6	116910006	116910006	C	T	Missense_Mutation	p.A91V	1
RWDD1	STAD	chr6	116912077	116912077	A	G	Missense_Mutation	p.N192D	1
RWDD1	LIHC	chr6	116901503	116901503	A	G	Missense_Mutation	p.E40G	1
RWDD1	SKCM	chr6	116911443	116911443	C	T	Silent	p.F45F	1
RWDD1	THYM	chr6	116892691	116892691	C	T	Missense_Mutation		1
RWDD1	SKCM	chr6	116914170	116914170	C	T	Missense_Mutation	p.S117F	1
RWDD1	BLCA	chr6	116914254	116914254	C	T	Missense_Mutation	p.S241L	1
RWDD1	LIHC	chr6	116910033	116910033	T	-	Frame_Shift_Del	p.I100fs	1
RWDD1	SKCM	chr6	116910104	116910104	G	A	Missense_Mutation	p.E124K	1
RWDD1	BLCA	chr6	116911482	116911482	G	A	Nonsense_Mutation	p.W154*	1
RWDD1	LIHC	chr6	116911558	116911558	A	-	Frame_Shift_Del	p.K180fs	1
RWDD1	SKCM	chr6	116911443	116911443	C	T	Silent	p.F141F	1
RWDD1	CESC	chr6	116901509	116901509	G	T	Missense_Mutation		1
RWDD1	LUSC	chr6	116906012	116906012	G	C	Missense_Mutation	p.A88P	1
RWDD1	SKCM	chr6	116910006	116910006	C	T	Splice_Site	p.A91_splice	1
RWDD1	CHOL	chr6	116901442	116901442	G	A	Missense_Mutation		1
RWDD1	MESO	chr6	116914158	116914158	A	G	Missense_Mutation	p.E209G	1
RWDD1	BLCA	chr6	116914146	116914146	G	C	Missense_Mutation		1
RWDD1	SKCM	chr6	116905895	116905895	C	T	Nonsense_Mutation	p.Q49*	1
RWDD1	ESCA	chr6	116906012	116906012	G	T	Missense_Mutation	p.A88S	1

Copy number variation (CNV) of RWDD1
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RWDD1
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
89398	Non-Cancer	2397N	HBS1L	chr6	135360710	-	RWDD1	chr6	116901457	+
78751	SARC	TCGA-SG-A6Z7-01A	RWDD1	chr6	116906020	+	CEP85L	chr6	118845083	-
78751	N/A	CD557821	RWDD1	chr6	116892643	+	DNAH12	chr3	57357606	-
78751	LUSC	TCGA-77-A5GH	RWDD1	chr6	116906020	+	FAM26D	chr6	116878988	+
78751	OV	TCGA-04-1338-01A	RWDD1	chr6	116901523	+	FAM26D	chr6	116864928	+
103224	N/A	BI494981	RWDD1	chr6	116914438	+	RASGRF1	chr15	79299907	-
93087	N/A	AF092134	RWDD1	chr6	116914431	+	STAU1	chr20	47745308	+
97040	BRCA	TCGA-E9-A1RF-01A	RWDD1	chr6	116892818	+	WASF1	chr6	110434663	-
97040	BRCA	TCGA-E9-A1RF-01A	RWDD1	chr6	116892818	+	WASF1	chr6	110448832	-
97040	BRCA	TCGA-E9-A1RF-01A	RWDD1	chr6	116895334	+	WASF1	chr6	110448832	-
89402	STAD	TCGA-D7-8579	TBC1D5	chr3	17783972	-	RWDD1	chr6	116914142	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
TGCT	RWDD1	0.00491748100436959	0.14
STAD	RWDD1	0.0137760387048914	0.37
LGG	RWDD1	0.0470032639854657	1

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	RWDD1	0.00826374526980962	0.27
PRAD	RWDD1	0.048365375629865	1
OV	RWDD1	0.0234881046015619	0.75
SARC	RWDD1	0.0356282915597182	1

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source