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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: PKM (NCBI Gene ID:5315)

Gene Summary

Gene Summary

Gene Information	Gene Name: PKM
	Gene ID: 5315
	Gene Symbol	PKM
	Gene ID	5315
	Gene Name	pyruvate kinase M1/2
	Synonyms	CTHBP\|HEL-S-30\|OIP3\|PK3\|PKM2\|TCB\|THBP1\|p58
	Cytomap	15q23
	Type of Gene	protein-coding
	Description	pyruvate kinase PKMOPA-interacting protein 3PK, muscle typecytosolic thyroid hormone-binding proteinepididymis secretory protein Li 30pyruvate kinase 2/3pyruvate kinase isozymes M1/M2pyruvate kinase muscle isozymepyruvate kinase, musclethyroid ho
	Modification date	20200329
	UniProtAcc	P14618

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0045727	Positive regulation of translation
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PKM	GO:0012501	programmed cell death	17308100

Inferred gene age of translation factor.

Gene

Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25

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Translation Studies in PubMed

We searched PubMed using 'PKM[title] AND translation [title] AND human.'

Gene	Title	PMID
PKM	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000335181	72492814	72492996	Frame-shift
ENST00000335181	72494794	72494961	Frame-shift
ENST00000335181	72502687	72502819	In-frame
ENST00000335181	72509749	72509841	Frame-shift

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000335181	72502687	72502819	2335	351	482	531	82	126

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type

Translation factor

adj.pval

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type

Gene

Coefficient

Pvalue

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with PKM (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type

Gene group

Translation factor

Correlated gene

Coefficient

Pvalue

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KICH	PKM	CTNNB1	1.35387002426383	0.000139892101287842
KIRP	PKM	CTNNB1	1.44413647030576	0.00019507110118866
LIHC	PKM	POU5F1	-4.77673145264574	0.000263325268073385
STAD	PKM	ENO1	-1.02325508064814	0.000557802151888609
KICH	PKM	HIF1A	-1.37204567854015	0.000808119773864746
HNSC	PKM	ENO3	-3.15004508978379	0.000837223107964747
HNSC	PKM	POU5F1	-1.82253221062701	0.0014147440645047
HNSC	PKM	GPI	1.68530042129652	0.00232809218027797
CHOL	PKM	ENO2	-1.21356853084993	0.00390625
LUSC	PKM	CTNNB1	-1.53686315879634	0.00765883184752251
CHOL	PKM	ENO3	-2.22249418908932	0.0078125
LIHC	PKM	ENO1	-1.32167947065926	0.0105240117726964
ESCA	PKM	ENO1	-1.15865001896573	0.013671875
CHOL	PKM	HIF1A	-2.15134609638655	0.01953125
ESCA	PKM	GPI	-4.8794108744339	0.0244140625
READ	PKM	ENO1	-2.94309512655985	0.03125
STAD	PKM	GPI	-3.9813176447297	0.0341199110262096
HNSC	PKM	ENO2	-2.20871168927252	1.30467014969327e-09
BRCA	PKM	GPI	-1.54280946928156	1.54535770084297e-07
LIHC	PKM	LDHA	-2.2244394752587	1.854004404664e-06
HNSC	PKM	HIF1A	2.27344501287138	2.8792055672966e-07
KIRC	PKM	GPI	2.68069334123605	3.51789336405112e-08
LIHC	PKM	ENO3	-1.18710994015525	3.95799979560965e-08
HNSC	PKM	LDHA	1.00445853437667	4.36986756540137e-05
KIRC	PKM	POU5F1	1.60944809981704	4.4523606197609e-12
PRAD	PKM	ENO2	1.26025847438339	5.02313257062788e-08
KIRC	PKM	ENO1	1.29733189096776	6.21583666708237e-08
KIRP	PKM	GPI	1.55524739106127	7.40401446819306e-05
LUAD	PKM	GPI	-4.39028273613752	9.63288627303132e-11
HNSC	PKM	ENO1	1.01360337851514	9.68786002886192e-05

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with PKM

TRIM63, BANF1, MGMT, HERC1, H2AFX, RNF185, UCHL5, Mapk13, HDAC5, Trim69, Nup188, Poc1b, AI837181, Csnk1e, Cdk1, Akap12, Tpr, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, PSMA3, RAP1B, GRB7, RPP14, TK1, CDKN1A, CDK4, NAGK, SMN1, RCC1, PIN1, ANXA7, NDRG1, ARRB1, ARRB2, ISG15, TERF1, TINF2, CUL3, CUL5, CUL2, CDK2, CUL1, COPS5, SHBG, MYOC, PML, APP, ENO3, GAPDH, FUBP1, PCBP1, TKT, PRDX2, PRDX6, IKBKAP, HIF1A, EGLN1, EGLN3, EP300, VCP, TRAF3IP1, HSP90AA1, HSP90AB1, FN1, ATF2, IQCB1, ITGA4, MPG, PAN2, CD81, IGSF8, NPM1, MAPK7, HDAC6, LMO7, RELA, PAX8, RAF1, EXOSC5, MDM2, NLK, YWHAQ, FBXO6, ACAT2, ANP32A, CBS, EIF4A3, NPLOC4, PDLIM5, CAPZA2, CTPS1, IPO11, PPP1CA, PLIN3, RAD23B, SRP14, TWF2, UBA2, STAU1, HUWE1, FUS, POLE2, NXT2, LNX1, CUL7, OBSL1, CCDC8, EZH2, SUZ12, SUMO1, CDK16, HNRNPA1, AGL, AKR1A1, ALDH5A1, ALDOA, AMDHD2, ASS1, BAX, DAZAP1, DNAJA3, EEF1D, FAM49B, FH, GNG12, HNRNPD, HNRNPK, HSPB1, LYPLA2, ME1, NANS, PFKM, PGK1, C9orf64, CFL1, EEF1A1, EEF1A2, LDHA, LDHAL6A, LDHB, PAICS, PFKL, PFKP, PPID, RAB10, RAC1, RPN1, SLC3A2, TRAP1, TUBA4A, TUBB, UFM1, NTRK1, PTEN, EWSR1, PPME1, CCDC88A, Cobll1, Pkm, ARAF, TRIM35, FGFR1, ETS1, USP7, CRY1, DDB2, EPM2A, MCM2, MCM5, CDC37, U2AF2, CDC25A, CTNNB1, CDC73, WWP2, ZNF746, CDH1, CYP1A1, SNRNP27, DDX19B, PAPLN, MYL2, AURKB, MAPK1, KPNA1, TRIM25, BRCA1, IFNAR1, PARK2, CFTR, KDM8, PKM, ZNF598, FBXO7, PSMD4, HDAC4, E7, UBE2M, PRPF8, EFTUD2, AAR2, PIH1D1, RPTOR, TNIP2, RNF4, TNF, CDC34, RIOK1, HEXIM1, MEPCE, LARP7, RNF123, SNAI1, AGR2, WWOX, RECQL4, STUB1, MYC, CDK9, KRT17, KIAA1429, ATG16L1, PHB, TGFBR2, FAF1, ZC3H7A, CHEK2, NR2C2, UBE3C, HDAC2, CTCF, OTUB2, AGRN, BMH2, BMH1, ATXN3, FAHD2A, ACAA2, TST, ISOC2, IDH2, LGALS3, MSRB2, PARK7, PRDX5, PPIA, TXNDC12, RAB7A, ACAT1, COA6, FABP3, AK3, TMEM205, SOD2, GSTK1, AK2, ICAM1, MDH2, PSMD14, TRIM44, GSK3B, BIRC3, PGRMC1, NFX1, BRD7, UBC, TRIM28, PLEKHA4, PINK1, YAP1, TFCP2, FANCD2, HCVgp1, LINC01554, HELLS, TP53, ULK1, ZC3H18, GRB2, EMC1, EMC2, EMC4, MMGT1, ANKRD55, M, nsp6, STAG1, NEK4, DLC1, DUX4, DUX4L9, ANLN, CHMP4C, CCR4, ECT2, KIF14, KIF20A, TRIM55, INS, SUMO2, NDN, Rnf183, HULC, BRD4, TRIM58, CIC, Apc2, RBM39, IFI16, EIF3F, UBE3A, CD47, CUL4A, RIN3, POU2F1, MKRN2, OGT, CD274, AR, UFL1, DDRGK1, NR4A1, DHFRL1, TRIM37, UBQLN1, FZR1, ARX, FXR1, FXR2, HOXA1, WDR5, TRAF4, PAGE4, NAA40, BGLT3, DANCR, PKLR, GOT1, ISCA1, SEMA4C, DNAJB6, SPRTN, USP11, BTF3, RC3H1, RC3H2, MBNL1, NLRP7, LHPP, nsp4, ORF8, FGD5, SLFN11, PDE4B, MAGEL2,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
PKM	chr15	72494854	G	A	single_nucleotide_variant	Likely_benign	not_specified	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant
PKM	chr15	72501005	T	C	single_nucleotide_variant	Uncertain_significance	not_specified	SO:0001583\|missense_variant	SO:0001583\|missense_variant
PKM	chr15	72501072	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PKM	chr15	72501099	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PKM	chr15	72501191	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PKM	chr15	72502141	G	A	single_nucleotide_variant	Benign	not_specified	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PKM	chr15	72502150	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
PKM	chr15	72502198	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
PKM	SKCM	chr15	72502746	72502746	G	A	Missense_Mutation	p.P107L	3
PKM	SKCM	chr15	72509755	72509755	G	A	Missense_Mutation	p.H81Y	3
PKM	SKCM	chr15	72492920	72492920	G	A	Nonsense_Mutation	p.Q462*	2
PKM	CESC	chr15	72502765	72502765	C	T	Missense_Mutation		2
PKM	SKCM	chr15	72511404	72511404	A	T	Missense_Mutation	p.F12Y	2
PKM	SKCM	chr15	72502030	72502030	G	A	Silent	p.L183L	2
PKM	LIHC	chr15	72499166	72499166	A	G	Missense_Mutation		2
PKM	SKCM	chr15	72501045	72501045	G	A	Silent	p.V251V	2
PKM	STAD	chr15	72502067	72502067	C	T	Missense_Mutation		2
PKM	LIHC	chr15	72492079	72492079	A	-	Frame_Shift_Del	p.F503fs	2
PKM	SKCM	chr15	72502751	72502751	G	A	Silent	p.Y105Y	2
PKM	STAD	chr15	72511394	72511394	G	A	Missense_Mutation		2
PKM	LIHC	chr15	72502127	72502127	T	-	Frame_Shift_Del	p.K151fs	2
PKM	UCS	chr15	72499185	72499185	G	A	Missense_Mutation	p.R342W	2
PKM	ESCA	chr15	72502159	72502159	G	A	Silent		2
PKM	STAD	chr15	72499498	72499498	T	C	Silent		2
PKM	UCS	chr15	72492887	72492887	G	A	Silent	p.L473L	2
PKM	MESO	chr15	72511284	72511284	C	A	Splice_Site		2
PKM	HNSC	chr15	72501133	72501133	G	A	Missense_Mutation	p.S222L	2
PKM	PAAD	chr15	72501087	72501087	A	G	Silent		2
PKM	HNSC	chr15	72502754	72502754	G	A	Silent	p.L104L	2
PKM	STAD	chr15	72511394	72511394	G	A	Missense_Mutation	p.P31L	2
PKM	ACC	chr15	72502105	72502105	C	A	Missense_Mutation	p.W158C	2
PKM	CESC	chr15	72492830	72492830	A	T	Missense_Mutation		2
PKM	TGCT	chr15	72502141	72502141	G	A	Silent		2
PKM	HNSC	chr15	72511446	72511446	G	T	Missense_Mutation		1
PKM	SARC	chr15	72501056	72501056	C	T	Splice_Site		1
PKM	BLCA	chr15	72499149	72499149	C	T	Missense_Mutation		1
PKM	KICH	chr15	72492092	72492092	C	T	Missense_Mutation		1
PKM	STAD	chr15	72499193	72499193	C	T	Missense_Mutation	p.R413H	1
PKM	THCA	chr15	72495521	72495521	A	G	Silent	p.R383R	1
PKM	LUAD	chr15	72499184	72499184	C	A	Missense_Mutation	p.R342L	1
PKM	HNSC	chr15	72511414	72511414	C	A	Missense_Mutation		1
PKM	SKCM	chr15	72501100	72501100	A	G	Missense_Mutation	p.V233A	1
PKM	BLCA	chr15	72495379	72495379	G	C	Missense_Mutation		1
PKM	KIRP	chr15	72502795	72502795	C	T	Missense_Mutation	p.V165M	1
PKM	STAD	chr15	72492905	72492905	G	A	Missense_Mutation	p.R541C	1
PKM	UCS	chr15	72492887	72492887	G	A	Silent		1
PKM	CESC	chr15	72492830	72492830	A	T	Missense_Mutation	p.F492I	1
PKM	LUAD	chr15	72502177	72502177	C	A	Silent	p.L134L	1
PKM	HNSC	chr15	72499499	72499499	C	A	Missense_Mutation		1
PKM	SKCM	chr15	72502197	72502197	C	T	Missense_Mutation	p.G128S	1
PKM	BLCA	chr15	72500994	72500994	G	T	Silent		1
PKM	KIRP	chr15	72499107	72499107	C	T	Missense_Mutation		1
PKM	STAD	chr15	72511433	72511433	C	T	Missense_Mutation	p.R18Q	1
PKM	UCS	chr15	72499185	72499185	G	A	Missense_Mutation		1
PKM	CESC	chr15	72502765	72502765	C	T	Missense_Mutation	p.D101N	1
PKM	LUAD	chr15	72511302	72511302	C	A	Missense_Mutation	p.G46V	1
PKM	HNSC	chr15	72509817	72509817	G	A	Missense_Mutation		1
PKM	SKCM	chr15	72511451	72511451	C	T	Splice_Site	p.G12_splice	1
PKM	BLCA	chr15	72501066	72501066	G	T	Missense_Mutation		1
PKM	STAD	chr15	72501132	72501132	C	T	Silent	p.S296S	1
PKM	UCS	chr15	72499185	72499185	G	A	Missense_Mutation	p.R416W	1
PKM	DLBC	chr15	72501072	72501072	C	T	Silent	p.A316A	1
PKM	LUAD	chr15	72495421	72495421	C	A	Missense_Mutation	p.V417L	1
PKM	HNSC	chr15	72501133	72501133	G	A	Missense_Mutation		1
PKM	BLCA	chr15	72492911	72492911	G	T	Missense_Mutation	p.L465M	1
PKM	STAD	chr15	72502148	72502148	A	G	Missense_Mutation	p.L218P	1
PKM	UCS	chr15	72492887	72492887	G	A	Silent	p.L547L	1
PKM	ESCA	chr15	72502159	72502159	G	A	Silent	p.L140	1
PKM	LUAD	chr15	72500960	72500960	G	A	Splice_Site		1
PKM	HNSC	chr15	72502754	72502754	G	A	Silent		1
PKM	BLCA	chr15	72499149	72499149	C	T	Missense_Mutation	p.D354N	1
PKM	STAD	chr15	72499084	72499084	C	T	Silent	p.V449V	1
PKM	LUAD	chr15	72502814	72502814	A	T	Missense_Mutation	p.H84Q	1
PKM	HNSC	chr15	72499611	72499611	C	T	Missense_Mutation	p.E282K	1
PKM	BLCA	chr15	72495379	72495379	G	C	Missense_Mutation	p.L431V	1
PKM	LIHC	chr15	72502719	72502719	C	-	Frame_Shift_Del	p.G116fs	1
PKM	STAD	chr15	72502067	72502067	C	T	Missense_Mutation	p.G171D	1
PKM	ESCA	chr15	72502159	72502159	G	A	Silent	p.L214L	1
PKM	STAD	chr15	72502067	72502067	C	T	Missense_Mutation	p.G245D	1
PKM	BLCA	chr15	72500975	72500975	C	A	Nonsense_Mutation	p.E275*	1
PKM	LIHC	chr15	72502772	72502772	A	-	Frame_Shift_Del	p.F98fs	1
PKM	STAD	chr15	72501212	72501212	C	T	Missense_Mutation	p.E196K	1
PKM	SKCM	chr15	72501222	72501222	G	A	Silent	p.F192F	1
PKM	ESCA	chr15	72502159	72502159	G	A	Silent	p.L140L	1
PKM	ACC	chr15	72502105	72502105	C	A	Missense_Mutation	p.W232C	1
PKM	BLCA	chr15	72494883	72494883	C	G	Missense_Mutation	p.D407H	1
PKM	LIHC	chr15	72492028	72492028	C	-	Frame_Shift_Del	p.G520fs	1
PKM	STAD	chr15	72499498	72499498	T	C	Silent	p.R319R	1
PKM	SKCM	chr15	72511434	72511434	G	A	Nonsense_Mutation	p.R18*	1
PKM	GBM	chr15	72499083	72499083	G	A	Missense_Mutation		1
PKM	PAAD	chr15	72501087	72501087	A	G	Silent	p.V311V	1
PKM	HNSC	chr15	72509817	72509817	G	A	Missense_Mutation	p.T60M	1
PKM	STAD	chr15	72499498	72499498	T	C	Silent	p.R393R	1
PKM	LUAD	chr15	72499545	72499545	C	A	Nonsense_Mutation	p.E304*	1
PKM	SKCM	chr15	72501167	72501167	G	A	Missense_Mutation	p.L211F	1
PKM	HNSC	chr15	72499611	72499611	C	T	Missense_Mutation		1
PKM	PAAD	chr15	72501087	72501087	A	G	Silent	p.V237V	1
PKM	BLCA	chr15	72492911	72492911	G	T	Missense_Mutation		1
PKM	HNSC	chr15	72511446	72511446	G	T	Missense_Mutation	p.Q14K	1
PKM	STAD	chr15	72511345	72511345	G	A	Missense_Mutation	p.R106C	1
PKM	THCA	chr15	72494909	72494909	A	T	Missense_Mutation	p.L398H	1
PKM	CESC	chr15	72521976	72521976	G	A	Missense_Mutation		1
PKM	LUAD	chr15	72495446	72495446	G	A	Silent	p.L408L	1

Copy number variation (CNV) of PKM
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across PKM
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
102786	SKCM	TCGA-EE-A29X-06A	AHNAK	chr11	62283631	-	PKM	chr15	72501232	-
102786	STAD	TCGA-CG-5721-01A	AHNAK	chr11	62284482	-	PKM	chr15	72491879	-
102786	N/A	BE262548	ARIH1	chr15	72827426	-	PKM	chr15	72509829	-
102786	N/A	BF246239	ATG10	chr5	81464726	-	PKM	chr15	72491468	-
102786	BRCA	TCGA-A8-A0A1-01A	B2M	chr15	45008554	+	PKM	chr15	72499618	-
102786	N/A	BI023877	B2M	chr15	45009974	+	PKM	chr15	72491384	+
102786	N/A	BM145002	BRINP2	chr1	177177792	+	PKM	chr15	72491375	+
102786	STAD	TCGA-CG-5721-01A	C1orf63	chr1	25571641	-	PKM	chr15	72494961	-
102786	N/A	BF765763	CHD6	chr20	40081436	+	PKM	chr15	72494962	-
102786	N/A	BU561657	CHODL	chr21	19617296	+	PKM	chr15	72502387	+
102786	N/A	BC001743	COA1	chr7	43606314	-	PKM	chr15	72498909	-
102786	LGG	TCGA-DU-A7TC-01A	EIF2AK4	chr15	40301931	+	PKM	chr15	72502819	-
102786	N/A	BF753099	ELF1	chr13	41507779	+	PKM	chr15	72502082	-
102786	N/A	AA295679	FAM83E	chr19	49118199	-	PKM	chr15	72499499	-
102786	N/A	BM148515	GHR	chr5	42684088	+	PKM	chr15	72491375	+
102786	HNSC	TCGA-BA-5558	GRAMD2	chr15	72490072	-	PKM	chr15	72492996	-
102786	HNSC	TCGA-BA-5558-01A	GRAMD2	chr15	72490072	-	PKM	chr15	72494961	-
102786	LUSC	TCGA-66-2744	IGHG2	chr14	106109961	-	PKM	chr15	72494079	-
102786	N/A	AA587791	KCNAB1	chr3	156222568	+	PKM	chr15	72491372	+
102786	N/A	BC051346	KRT18	chr12	53343622	+	PKM	chr15	72499549	-
102786	STAD	TCGA-FP-8211-01A	LIPH	chr3	185270211	-	PKM	chr15	72511451	-
102786	UCEC	TCGA-D1-A16G-01A	MYO9A	chr15	72410021	-	PKM	chr15	72511451	-
102786	N/A	AX379193	NUP214	chr9	134050932	+	PKM	chr15	72502719	-
102786	N/A	AU125105	PANK3	chr5	167977673	-	PKM	chr15	72523531	-
98691	N/A	BF245908	PKM	chr15	72491375	-	ASIC2	chr17	32190937	-
95255	N/A	CF593344	PKM	chr15	72502718	-	BASP1	chr5	17275741	+
98983	N/A	CV350694	PKM	chr15	72502083	+	BCR	chr22	23612698	+
65761	LUSC	TCGA-85-8664-01A	PKM	chr15	72523457	-	CELF6	chr15	72582596	-
101222	N/A	BF763536	PKM	chr15	72494962	+	CHD6	chr20	40081436	-
93353	N/A	BG959892	PKM	chr15	72491429	-	CNTROB	chr17	7852891	-
65761	STAD	TCGA-HU-A4GJ-01A	PKM	chr15	72523457	-	COX5A	chr15	75221573	-
100212	N/A	BP429816	PKM	chr15	72491372	-	DYRK1A	chr21	38825083	-
101940	N/A	BF216947	PKM	chr15	72491372	-	EBF3	chr10	131684330	-
71641	N/A	AK098360	PKM	chr15	72502078	+	FAIM2	chr12	50283340	-
86127	N/A	BQ324461	PKM	chr15	72502156	-	FUS	chr16	31195543	+
97059	N/A	CF146312	PKM	chr15	72491372	-	INPP5J	chr22	31507812	+
102796	N/A	EC584988	PKM	chr15	72494860	+	KLK3	chr19	51359485	+
98898	BRCA	TCGA-B6-A0IO-01A	PKM	chr15	72509750	-	MCTP2	chr15	94942190	+
94957	N/A	BM554547	PKM	chr15	72491714	-	MORN2	chr2	39108581	+
103043	N/A	AX395902	PKM	chr15	72491417	-	MYH14	chr19	50813191	+
93001	N/A	AX260605	PKM	chr15	72502719	+	NUP214	chr9	134050932	-
91854	OV	TCGA-61-1914-01A	PKM	chr15	72511285	-	PARP6	chr15	72535040	-
77621	N/A	EC556197	PKM	chr15	72491767	-	PIAS3	chr1	145586436	-
65761	Non-Cancer	ERR188258	PKM	chr15	72500964	-	PKLR	chr1	155264178	-
102786	N/A	AA650292	PKM	chr15	72521234	-	PKM	chr15	72521266	+
102786	N/A	AI821115	PKM	chr15	72521266	-	PKM	chr15	72521234	+
102786	N/A	CA771395	PKM	chr15	72502145	-	PKM	chr15	72502023	+
102786	N/A	CB159102	PKM	chr15	72499215	+	PKM	chr15	72491532	-
102786	N/A	CF132406	PKM	chr15	72499187	-	PKM	chr15	72502747	-
102786	N/A	CN481707	PKM	chr15	72509806	-	PKM	chr15	72523325	-
85814	N/A	CN308615	PKM	chr15	72511434	-	PPM1A	chr14	60759640	+
65761	N/A	BQ027595	PKM	chr15	72515382	+	PPM1F	chr22	22273798	+
69867	N/A	CD579366	PKM	chr15	72501007	-	PTCH1	chr9	98246000	-
70025	N/A	AA713524	PKM	chr15	72491784	+	PTK2B	chr8	27293799	-
101183	N/A	BP222551	PKM	chr15	72502110	-	RBM33	chr7	155537982	+
99494	N/A	BE388611	PKM	chr15	72501125	-	RPS3	chr11	75110594	+
94379	N/A	EC514792	PKM	chr15	72494927	-	SH3GLB2	chr9	131770643	-
96777	SKCM	TCGA-DA-A1IA-06A	PKM	chr15	72502759	-	SPARC	chr5	151051168	-
85690	N/A	BF798347	PKM	chr15	72523543	+	SQLE	chr8	126023804	+
102305	N/A	AW391494	PKM	chr15	72491784	+	STX8	chr17	9190048	-
65761	N/A	AA532972	PKM	chr15	72515382	+	TIMM10	chr11	57296110	+
65761	BRCA	TCGA-BH-A18V-01A	PKM	chr15	72502014	-	TRPV3	chr17	3439007	-
65761	BRCA	TCGA-BH-A18V-06A	PKM	chr15	72502014	-	TRPV3	chr17	3436231	-
98976	N/A	BF204709	PKM	chr15	72523241	+	TUSC3	chr8	15397794	+
98402	N/A	BQ328230	PKM	chr15	72499482	-	VCAM1	chr1	101188620	+
102786	STAD	TCGA-HU-A4GN-01A	PQLC3	chr2	11300820	+	PKM	chr15	72513625	-
102786	GBM	TCGA-14-1402-02A	PRMT2	chr21	48078832	+	PKM	chr15	72511451	-
102786	N/A	CN332118	PRNP	chr20	4680117	+	PKM	chr15	72491944	-
102786	N/A	BQ183886	PSMD3	chr17	38154073	-	PKM	chr15	72492925	+
102786	N/A	CD365065	RAC1	chr7	6442108	-	PKM	chr15	72499561	+
102786	STAD	TCGA-D7-5577-01A	RPS10	chr6	34392446	-	PKM	chr15	72492996	-
102786	N/A	BM828121	SHFM1	chr7	96329921	-	PKM	chr15	72523542	-
102786	N/A	BE816196	SON	chr21	34929569	-	PKM	chr15	72502012	+
102786	N/A	BI009652	SQSTM1	chr5	179251073	-	PKM	chr15	72494881	-
102786	N/A	BQ315333	SRL	chr16	4277702	+	PKM	chr15	72502075	-
102786	N/A	CF131223	TP53INP1	chr8	95953237	-	PKM	chr15	72511380	-
102790	N/A	AW884014	ZNF710	chr15	90608971	+	PKM	chr15	72491794	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type

Translation factor

pval

adj.p

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type

Translation factor

pval

adj.p

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
P14618	DB00119	Pyruvic acid		Small molecule	Approved\|Investigational\|Nutraceutical
P14618	DB01733	L-Phospholactate		Small molecule	Experimental
P14618	DB02726	2-Phosphoglycolic Acid		Small molecule	Experimental
P14618	DB07628	6-(2-fluorobenzyl)-2,4-dimethyl-4,6-dihydro-5H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one		Small molecule	Experimental
P14618	DB07692	1-[(2,6-difluorophenyl)sulfonyl]-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)piperazine		Small molecule	Experimental
P14618	DB07697	1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-[(4-methoxyphenyl)sulfonyl]piperazine		Small molecule	Experimental
P14618	DB00119	Pyruvic acid
P14618	DB01733	L-Phospholactate
P14618	DB02726	2-Phosphoglycolic Acid
P14618	DB07628	6-(2-fluorobenzyl)-2,4-dimethyl-4,6-dihydro-5H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one
P14618	DB07692	1-[(2,6-difluorophenyl)sulfonyl]-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)piperazine
P14618	DB07697	1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-[(4-methoxyphenyl)sulfonyl]piperazine

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0001787	Osteoporosis, Age-Related	1	CTD_human
C0029456	Osteoporosis	1	CTD_human
C0029459	Osteoporosis, Senile	1	CTD_human
C0205696	Anaplastic carcinoma	1	CTD_human
C0205697	Carcinoma, Spindle-Cell	1	CTD_human
C0205698	Undifferentiated carcinoma	1	CTD_human
C0751406	Post-Traumatic Osteoporosis	1	CTD_human
C1257925	Mammary Carcinoma, Animal	1	CTD_human
C2239176	Liver carcinoma	1	CTD_human