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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: MRPS21 (NCBI Gene ID:54460)

Gene Summary

Gene Summary

Gene Information	Gene Name: MRPS21
	Gene ID: 54460
	Gene Symbol	MRPS21
	Gene ID	54460
	Gene Name	mitochondrial ribosomal protein S21
	Synonyms	MDS016\|MRP-S21\|RPMS21
	Cytomap	1q21.2
	Type of Gene	protein-coding
	Description	28S ribosomal protein S21, mitochondrialS21mtmitochondrial 28S ribosomal protein S21mitochondrial small ribosomal subunit protein bS21m
	Modification date	20200313
	UniProtAcc	P82921

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0032543	Mitochondrial translation
GO:0005840	Ribosome
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
MRPS21	(733 - 1119.25]

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Translation Studies in PubMed

We searched PubMed using 'MRPS21[title] AND translation [title] AND human.'

Gene	Title	PMID
MRPS21	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

ORF

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
LUSC	MRPS21	-1.06738210898451	0.00291962754379891
KIRP	MRPS21	-1.88933102521932	0.0413399673998356
BRCA	MRPS21	-1.81975786291087	1.52500483244108e-06
LUAD	MRPS21	-2.12828541655424	4.20890892730867e-05

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
UCEC	MRPS21	3	2	0.001897191560158	0.651721221221222	0.388490845443536	0.261464529321168	0.451750618134881

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
UCEC	MRPS21	0.135995889	0.014132587

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with MRPS21 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
ACC	Cell metabolism gene	MRPS21	PFDN2	0.803194915	5.34E-19
GBM	Cell metabolism gene	MRPS21	PSMB4	0.822726007	1.46E-43
KIRP	Cell metabolism gene	MRPS21	POLR2I	0.807936011	1.03E-75
KIRP	Cell metabolism gene	MRPS21	DPM3	0.810343796	1.67E-76
KIRP	Cell metabolism gene	MRPS21	PPOX	0.816725339	1.20E-78
KIRP	Cell metabolism gene	MRPS21	MTX1	0.820553167	5.66E-80
KIRP	Cell metabolism gene	MRPS21	PFDN6	0.832436747	2.66E-84
KIRP	TSG	MRPS21	GADD45GIP1	0.831105812	8.43E-84
LGG	Cell metabolism gene	MRPS21	PSMD4	0.806391235	1.51E-122
LIHC	Cell metabolism gene	MRPS21	PSMB4	0.801554264	4.49E-96
PCPG	Cell metabolism gene	MRPS21	PSMD4	0.833322127	1.66E-49
PCPG	Cell metabolism gene	MRPS21	PSMB4	0.868577813	2.63E-58
PRAD	Cell metabolism gene	MRPS21	PSMB7	0.807306562	1.27E-127
PRAD	Cell metabolism gene	MRPS21	PSMB4	0.812316679	1.98E-130
PRAD	Cell metabolism gene	MRPS21	PSMB3	0.813754744	2.99E-131
PRAD	Cell metabolism gene	MRPS21	PSMD4	0.828636459	3.39E-140
PRAD	Cell metabolism gene	MRPS21	FAU	0.832395365	1.36E-142
PRAD	Cell metabolism gene	MRPS21	SNRPD2	0.833546228	2.44E-143
PRAD	Cell metabolism gene	MRPS21	PFDN6	0.83724743	8.91E-146
PRAD	Cell metabolism gene	MRPS21	DPM3	0.837249182	8.88E-146
PRAD	Cell metabolism gene	MRPS21	POLR2F	0.84083891	3.35E-148
PRAD	Cell metabolism gene	MRPS21	POLR2I	0.843704753	3.52E-150
PRAD	Epifactor	MRPS21	RBX1	0.801506193	1.80E-124
PRAD	Epifactor	MRPS21	TAF10	0.802689302	4.18E-125
PRAD	Epifactor	MRPS21	ZNHIT1	0.818440247	5.60E-134
PRAD	TF	MRPS21	DRAP1	0.812626541	1.32E-130
PRAD	TSG	MRPS21	GADD45GIP1	0.850764341	3.14E-155
THCA	Cell metabolism gene	MRPS21	SNRPD2	0.800541536	7.38E-129
THCA	Cell metabolism gene	MRPS21	PSMB4	0.811184999	6.37E-135
THCA	Cell metabolism gene	MRPS21	POLR2I	0.814072297	1.24E-136
THCA	Cell metabolism gene	MRPS21	POLR2J	0.826027384	4.71E-144
THCA	Cell metabolism gene	MRPS21	PFDN6	0.82636826	2.84E-144
THCA	Cell metabolism gene	MRPS21	DPM3	0.858486931	1.89E-167
THCA	Epifactor	MRPS21	ZNHIT1	0.800923374	4.54E-129
THCA	Epifactor	MRPS21	TAF10	0.812313613	1.38E-135
THCA	TSG	MRPS21	GADD45GIP1	0.821467728	3.70E-141
THYM	Cell metabolism gene	MRPS21	TBCB	0.801164168	1.58E-28
THYM	Cell metabolism gene	MRPS21	ACOT8	0.803041636	9.50E-29
THYM	Cell metabolism gene	MRPS21	EXOSC4	0.806633525	3.53E-29
THYM	Cell metabolism gene	MRPS21	PHPT1	0.808865417	1.89E-29
THYM	Cell metabolism gene	MRPS21	PSMB3	0.809316579	1.66E-29
THYM	Cell metabolism gene	MRPS21	EXOSC5	0.811755905	8.31E-30
THYM	Cell metabolism gene	MRPS21	MED27	0.811827731	8.14E-30
THYM	Cell metabolism gene	MRPS21	APRT	0.812303971	7.10E-30
THYM	Cell metabolism gene	MRPS21	MIF	0.813086006	5.66E-30
THYM	Cell metabolism gene	MRPS21	PHKG2	0.813717594	4.72E-30
THYM	Cell metabolism gene	MRPS21	TAZ	0.81392893	4.44E-30
THYM	Cell metabolism gene	MRPS21	GSTZ1	0.815051196	3.20E-30
THYM	Cell metabolism gene	MRPS21	ITPA	0.815381645	2.90E-30
THYM	Cell metabolism gene	MRPS21	PSMC1	0.815758781	2.60E-30
THYM	Cell metabolism gene	MRPS21	FH	0.816022313	2.41E-30
THYM	Cell metabolism gene	MRPS21	TIMM8B	0.816380121	2.16E-30
THYM	Cell metabolism gene	MRPS21	HSD17B10	0.816652182	2.00E-30
THYM	Cell metabolism gene	MRPS21	TOMM5	0.817649697	1.49E-30
THYM	Cell metabolism gene	MRPS21	CYC1	0.818397614	1.19E-30
THYM	Cell metabolism gene	MRPS21	SNRPE	0.820682014	5.98E-31
THYM	Cell metabolism gene	MRPS21	GUK1	0.821738891	4.34E-31
THYM	Cell metabolism gene	MRPS21	EBP	0.822539918	3.40E-31
THYM	Cell metabolism gene	MRPS21	NANS	0.824354434	1.94E-31
THYM	Cell metabolism gene	MRPS21	TIMM50	0.826814625	9.01E-32
THYM	Cell metabolism gene	MRPS21	POLR2J	0.827698888	6.82E-32
THYM	Cell metabolism gene	MRPS21	TSTA3	0.828076998	6.05E-32
THYM	Cell metabolism gene	MRPS21	TIMM17B	0.830862471	2.48E-32
THYM	Cell metabolism gene	MRPS21	TOMM40	0.836126248	4.39E-33
THYM	Cell metabolism gene	MRPS21	GEMIN6	0.839902428	1.22E-33
THYM	Cell metabolism gene	MRPS21	COX17	0.845262536	1.87E-34
THYM	Cell metabolism gene	MRPS21	GEMIN7	0.845350077	1.81E-34
THYM	Cell metabolism gene	MRPS21	PSME2	0.845739311	1.58E-34
THYM	Cell metabolism gene	MRPS21	POLR2H	0.857664754	1.84E-36
THYM	Cell metabolism gene	MRPS21	ATP5G1	0.864596764	1.14E-37
THYM	Cell metabolism gene	MRPS21	WBSCR22	0.874552832	1.59E-39
THYM	Cell metabolism gene	MRPS21	POLR2I	0.876368024	6.99E-40
THYM	Cell metabolism gene	MRPS21	DPM3	0.885629547	8.70E-42
THYM	Cell metabolism gene	MRPS21	MTX1	0.893025127	1.98E-43
THYM	Cell metabolism gene	MRPS21	PPOX	0.894941016	7.09E-44
THYM	Cell metabolism gene	MRPS21	PFDN2	0.90327313	6.42E-46
THYM	Cell metabolism gene	MRPS21	PSMD4	0.911795407	3.29E-48
THYM	Cell metabolism gene	MRPS21	PSMB4	0.922527071	1.89E-51
THYM	CGC	MRPS21	FH	0.816022313	2.41E-30
THYM	CGC	MRPS21	COX6C	0.8960125	3.96E-44
THYM	Epifactor	MRPS21	EXOSC4	0.806633525	3.53E-29
THYM	Epifactor	MRPS21	TAF10	0.808410711	2.15E-29
THYM	Epifactor	MRPS21	EXOSC5	0.811755905	8.31E-30
THYM	Epifactor	MRPS21	SIRT6	0.816968045	1.82E-30
THYM	Epifactor	MRPS21	ZNHIT1	0.827708292	6.80E-32
THYM	Epifactor	MRPS21	CDK5	0.831687605	1.90E-32
THYM	IUPHAR	MRPS21	PHKG2	0.813717594	4.72E-30
THYM	IUPHAR	MRPS21	ATP6V1F	0.816103581	2.35E-30
THYM	IUPHAR	MRPS21	SIRT6	0.816968045	1.82E-30
THYM	IUPHAR	MRPS21	CDK5	0.831687605	1.90E-32
THYM	Kinase	MRPS21	PHKG2	0.813717594	4.72E-30
THYM	Kinase	MRPS21	CDK5	0.831687605	1.90E-32
THYM	Kinase	MRPS21	FASTK	0.871040695	7.45E-39
THYM	TF	MRPS21	ZNF787	0.803074152	9.41E-29
THYM	TF	MRPS21	ZNF688	0.804114494	7.08E-29
THYM	TF	MRPS21	USF1	0.823932701	2.21E-31
THYM	TF	MRPS21	ZNF692	0.837668229	2.61E-33
THYM	TF	MRPS21	GLI4	0.838483719	1.98E-33
THYM	TSG	MRPS21	NPRL2	0.802611673	1.07E-28
THYM	TSG	MRPS21	PDCD5	0.805768864	4.49E-29
THYM	TSG	MRPS21	FH	0.816022313	2.41E-30
THYM	TSG	MRPS21	SIRT6	0.816968045	1.82E-30
THYM	TSG	MRPS21	ST20	0.825879615	1.21E-31
THYM	TSG	MRPS21	GADD45GIP1	0.840900722	8.65E-34
UCS	Cell metabolism gene	MRPS21	TBCB	0.801164168	1.58E-28
UCS	Cell metabolism gene	MRPS21	ACOT8	0.803041636	9.50E-29
UCS	Cell metabolism gene	MRPS21	EXOSC4	0.806633525	3.53E-29
UCS	Cell metabolism gene	MRPS21	PHPT1	0.808865417	1.89E-29
UCS	Cell metabolism gene	MRPS21	PSMB3	0.809316579	1.66E-29
UCS	Cell metabolism gene	MRPS21	EXOSC5	0.811755905	8.31E-30
UCS	Cell metabolism gene	MRPS21	MED27	0.811827731	8.14E-30
UCS	Cell metabolism gene	MRPS21	APRT	0.812303971	7.10E-30
UCS	Cell metabolism gene	MRPS21	MIF	0.813086006	5.66E-30
UCS	Cell metabolism gene	MRPS21	PHKG2	0.813717594	4.72E-30
UCS	Cell metabolism gene	MRPS21	TAZ	0.81392893	4.44E-30
UCS	Cell metabolism gene	MRPS21	GSTZ1	0.815051196	3.20E-30
UCS	Cell metabolism gene	MRPS21	ITPA	0.815381645	2.90E-30
UCS	Cell metabolism gene	MRPS21	PSMC1	0.815758781	2.60E-30
UCS	Cell metabolism gene	MRPS21	FH	0.816022313	2.41E-30
UCS	Cell metabolism gene	MRPS21	TIMM8B	0.816380121	2.16E-30
UCS	Cell metabolism gene	MRPS21	HSD17B10	0.816652182	2.00E-30
UCS	Cell metabolism gene	MRPS21	TOMM5	0.817649697	1.49E-30
UCS	Cell metabolism gene	MRPS21	CYC1	0.818397614	1.19E-30
UCS	Cell metabolism gene	MRPS21	SNRPE	0.820682014	5.98E-31
UCS	Cell metabolism gene	MRPS21	GUK1	0.821738891	4.34E-31
UCS	Cell metabolism gene	MRPS21	EBP	0.822539918	3.40E-31
UCS	Cell metabolism gene	MRPS21	NANS	0.824354434	1.94E-31
UCS	Cell metabolism gene	MRPS21	TIMM50	0.826814625	9.01E-32
UCS	Cell metabolism gene	MRPS21	POLR2J	0.827698888	6.82E-32
UCS	Cell metabolism gene	MRPS21	TSTA3	0.828076998	6.05E-32
UCS	Cell metabolism gene	MRPS21	TIMM17B	0.830862471	2.48E-32
UCS	Cell metabolism gene	MRPS21	TOMM40	0.836126248	4.39E-33
UCS	Cell metabolism gene	MRPS21	GEMIN6	0.839902428	1.22E-33
UCS	Cell metabolism gene	MRPS21	COX17	0.845262536	1.87E-34
UCS	Cell metabolism gene	MRPS21	GEMIN7	0.845350077	1.81E-34
UCS	Cell metabolism gene	MRPS21	PSME2	0.845739311	1.58E-34
UCS	Cell metabolism gene	MRPS21	POLR2H	0.857664754	1.84E-36
UCS	Cell metabolism gene	MRPS21	ATP5G1	0.864596764	1.14E-37
UCS	Cell metabolism gene	MRPS21	WBSCR22	0.874552832	1.59E-39
UCS	Cell metabolism gene	MRPS21	POLR2I	0.876368024	6.99E-40
UCS	Cell metabolism gene	MRPS21	DPM3	0.885629547	8.70E-42
UCS	Cell metabolism gene	MRPS21	MTX1	0.893025127	1.98E-43
UCS	Cell metabolism gene	MRPS21	PPOX	0.894941016	7.09E-44
UCS	Cell metabolism gene	MRPS21	PFDN2	0.90327313	6.42E-46
UCS	Cell metabolism gene	MRPS21	PSMD4	0.911795407	3.29E-48
UCS	Cell metabolism gene	MRPS21	PSMB4	0.922527071	1.89E-51
UCS	CGC	MRPS21	FH	0.816022313	2.41E-30
UCS	CGC	MRPS21	COX6C	0.8960125	3.96E-44
UCS	Epifactor	MRPS21	EXOSC4	0.806633525	3.53E-29
UCS	Epifactor	MRPS21	TAF10	0.808410711	2.15E-29
UCS	Epifactor	MRPS21	EXOSC5	0.811755905	8.31E-30
UCS	Epifactor	MRPS21	SIRT6	0.816968045	1.82E-30
UCS	Epifactor	MRPS21	ZNHIT1	0.827708292	6.80E-32
UCS	Epifactor	MRPS21	CDK5	0.831687605	1.90E-32
UCS	IUPHAR	MRPS21	PHKG2	0.813717594	4.72E-30
UCS	IUPHAR	MRPS21	ATP6V1F	0.816103581	2.35E-30
UCS	IUPHAR	MRPS21	SIRT6	0.816968045	1.82E-30
UCS	IUPHAR	MRPS21	CDK5	0.831687605	1.90E-32
UCS	Kinase	MRPS21	PHKG2	0.813717594	4.72E-30
UCS	Kinase	MRPS21	CDK5	0.831687605	1.90E-32
UCS	Kinase	MRPS21	FASTK	0.871040695	7.45E-39
UCS	TF	MRPS21	ZNF787	0.803074152	9.41E-29
UCS	TF	MRPS21	ZNF688	0.804114494	7.08E-29
UCS	TF	MRPS21	USF1	0.823932701	2.21E-31
UCS	TF	MRPS21	ZNF692	0.837668229	2.61E-33
UCS	TF	MRPS21	GLI4	0.838483719	1.98E-33
UCS	TSG	MRPS21	NPRL2	0.802611673	1.07E-28
UCS	TSG	MRPS21	PDCD5	0.805768864	4.49E-29
UCS	TSG	MRPS21	FH	0.816022313	2.41E-30
UCS	TSG	MRPS21	SIRT6	0.816968045	1.82E-30
UCS	TSG	MRPS21	ST20	0.825879615	1.21E-31
UCS	TSG	MRPS21	GADD45GIP1	0.840900722	8.65E-34
UVM	Cell metabolism gene	MRPS21	PFDN2	0.809912095	9.36E-20
UVM	Cell metabolism gene	MRPS21	POLR2J	0.815567557	3.23E-20
UVM	Cell metabolism gene	MRPS21	SNRPF	0.816438731	2.74E-20
UVM	Cell metabolism gene	MRPS21	POLR2F	0.819585196	1.49E-20
UVM	Cell metabolism gene	MRPS21	PSMD4	0.842314094	1.23E-22
UVM	Cell metabolism gene	MRPS21	SNRPD2	0.849100704	2.53E-23
UVM	TSG	MRPS21	GADD45GIP1	0.820652146	1.20E-20

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
BRCA	MRPS21	MRPS27	-2.1331392862776	0.000127527962379903
BRCA	MRPS21	MRPS33	-2.50367423576272	0.000154377851145473
LIHC	MRPS21	MRPS31	-1.07565232256163	0.000180054839259286
BRCA	MRPS21	MRPS15	-2.19567551682318	0.000188684660674703
KICH	MRPS21	MRPS5	1.25108287838437	0.000249803066253662
KIRC	MRPS21	MRPS18B	-1.08999348010674	0.00208385211535325
LUAD	MRPS21	MRPS31	1.58140915700442	0.00351308111790755
KIRC	MRPS21	MRPS15	1.11572283836012	0.00361818577801855
CHOL	MRPS21	MRPS18B	-1.34341961473083	0.0078125
CHOL	MRPS21	MRPS6	2.57097392409939	0.0078125
LUSC	MRPS21	MRPS6	-1.26158810839259	0.013873001943322
THCA	MRPS21	MRPS15	-1.19960602422995	0.0140154883942907
KICH	MRPS21	MRPS31	-1.44171613577495	0.0173123478889465
BLCA	MRPS21	MRPS18B	-2.79316203705083	0.0180816650390625
ESCA	MRPS21	MRPS5	-2.15440118747854	0.0185546875
LUAD	MRPS21	MRPS18B	-2.59132604284176	0.0228310323601027
THCA	MRPS21	MRPS11	-3.10694728540962	0.0252226935182201
COAD	MRPS21	MRPS31	1.25930610083678	0.0253507494926453
STAD	MRPS21	MRPS18B	-2.18783845061495	0.0341199110262096
BLCA	MRPS21	MRPS11	-2.30276998968219	0.040130615234375
BLCA	MRPS21	MRPS31	-1.74989716581638	0.0445594787597656
THCA	MRPS21	MRPS10	1.33413691764991	1.55171507174296e-05
LUAD	MRPS21	MRPS5	-2.20881945885927	1.77904381378076e-06
LUAD	MRPS21	MRPS27	-2.46461120873599	2.13247131179291e-05
BRCA	MRPS21	MRPS11	-1.24304977976804	2.31302509538916e-07
LUAD	MRPS21	MRPL42	-6.34610249602491	2.48255276366547e-08
PRAD	MRPS21	MRPS6	1.00673230965164	3.48152859299693e-07
LUSC	MRPS21	MRPS5	-7.65956389962319	4.27210217182982e-06
KIRC	MRPS21	MRPS6	-3.12621933743663	4.95376546353503e-10
KIRC	MRPS21	MRPL42	-4.382095336248	5.26630854166927e-06
LUSC	MRPS21	MRPS11	-2.9004097541444	5.43966600483641e-07
LUSC	MRPS21	MRPS33	-3.32702669971865	5.71093314566242e-07
PRAD	MRPS21	MRPS31	1.42878008978338	6.76861513404814e-05
THCA	MRPS21	MRPS31	-1.55759809933211	6.91106419786075e-09
KICH	MRPS21	MRPS6	-1.34376231922276	7.49826431274414e-05
KIRC	MRPS21	MRPS31	-4.32541004240865	9.31897250092369e-08

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with MRPS21

USP42, USP44, ICT1, CUL3, CAND1, MRPS9, MYL12A, MOV10, NDUFS2, RPS21, LAMTOR2, HNRNPR, NDUFAF3, TUBGCP3, SHMT2, NXF1, RNF2, TRA2A, RPL6, ZC3H3, TRMT10B, MRPS31, RPLP2, LDHD, Ttll12, CDC14B, DUSP11, MRPS34, MRPS15, MRPS11, MRPS27, AURKAIP1, RBM42, COX15, ATP5A1, GTF2H4, KCTD10, LEO1, MAPKAP1, MRPL36, MRPL37, MRPS5, GATB, PGK1, PSMC1, WDR61, EFTUD2, HEXIM1, MEPCE, LARP7, RECQL4, MRM1, HSPD1, TCF7L2, SNRNP70, HMGB1, OBSL1, GRB7, PRKAA1, CHMP4C, KIF14, KIF23, C12orf65, FASTKD5, GFM1, GRSF1, LRPPRC, MDH2, METTL15, METTL17, MTERF3, MTIF2, MTIF3, SLIRP, TBRG4, TFAM, TRUB2, EXD2, ACACA, MAFB, HSCB, PADI4, FZR1, RBMS2, HNRNPU, CCDC59, MRPS26, MRPS18B, MRPS25, MRPS6, ZNF460, MRPS17, H1FNT, SRSF3, PRR3, MRPS18C, ZNF467, MRPS23, RPS9, YBX1, MRPL2, SRSF1, SRSF6, RPL35, MRPS2, SRP14, MRPS24, APOBEC3D, MCAT, RPL10, ABT1, CCNF, SQSTM1, KLF15,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
MRPS21	KIRC	chr1	150266811	150266811	G	A	Missense_Mutation	p.A9T	4
MRPS21	LUAD	chr1	150280583	150280583	G	T	Missense_Mutation	p.R62L	2
MRPS21	SARC	chr1	150280620	150280620	C	A	Missense_Mutation	p.F74L	2
MRPS21	STAD	chr1	150266811	150266811	G	A	Missense_Mutation		2
MRPS21	LIHC	chr1	150266814	150266814	A	T	Missense_Mutation		2
MRPS21	LIHC	chr1	150266814	150266814	A	T	Missense_Mutation	p.R10W	2
MRPS21	UCEC	chr1	150280607	150280607	G	A	Missense_Mutation	p.R70H	2
MRPS21	UCEC	chr1	150280627	150280627	C	T	Nonsense_Mutation	p.R77*	2
MRPS21	CESC	chr1	150280628	150280628	G	A	Missense_Mutation		2
MRPS21	CESC	chr1	150266492	150266492	C	G	Missense_Mutation		1
MRPS21	LUAD	chr1	150280578	150280578	C	G	Missense_Mutation	p.C60W	1
MRPS21	CESC	chr1	150280628	150280628	G	A	Missense_Mutation	p.R77Q	1
MRPS21	PAAD	chr1	150280587	150280587	C	A	Silent		1
MRPS21	COAD	chr1	150280621	150280621	T	G	Missense_Mutation	p.L75V	1
MRPS21	PAAD	chr1	150280587	150280587	C	A	Silent	p.I63I	1
MRPS21	DLBC	chr1	150280546	150280546	C	T	Missense_Mutation	p.R50C	1
MRPS21	SARC	chr1	150280620	150280620	C	A	Missense_Mutation		1
MRPS21	SARC	chr1	150280547	150280547	G	T	Missense_Mutation		1
MRPS21	LGG	chr1	150266802	150266802	A	C	Missense_Mutation	p.K6Q	1
MRPS21	LGG	chr1	150266802	150266802	A	C	Missense_Mutation		1
MRPS21	BLCA	chr1	150280533	150280533	T	C	Silent		1
MRPS21	THCA	chr1	150280498	150280498	G	T	Missense_Mutation		1
MRPS21	BLCA	chr1	150280533	150280533	T	C	Silent	p.Y45Y	1
MRPS21	BLCA	chr1	150280534	150280534	G	T	Nonsense_Mutation	p.E46*	1
MRPS21	LIHC	chr1	150280637	150280637	G	-	Frame_Shift_Del	p.R80fs	1

Copy number variation (CNV) of MRPS21
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across MRPS21
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
89113	N/A	BI494414	ANKS1B	chr12	99160786	+	MRPS21	chr1	150280783	-
89113	LGG	TCGA-FG-8191	ARNT	chr1	150818738	-	MRPS21	chr1	150280481	+
89113	SARC	TCGA-Z4-AAPF-01A	ATP2B4	chr1	203696699	+	MRPS21	chr1	150280482	+
102060	N/A	BI494415	MRPS21	chr1	150280783	+	BRD8	chr5	137511595	+
78680	BRCA	TCGA-BH-A203-01A	MRPS21	chr1	150266869	+	CA14	chr1	150236993	+
91839	N/A	EC510702	MRPS21	chr1	150280723	-	CXorf40B	chrX	149100444	-
94198	N/A	BP392984	MRPS21	chr1	150266322	-	DAP	chr5	10679800	-
102445	N/A	BU175700	MRPS21	chr1	150280782	+	RPS5	chr19	58904724	+
101750	N/A	AV681658	MRPS21	chr1	150280783	+	SCAPER	chr15	76785231	-
89113	STAD	TCGA-HU-A4GT-01A	PRPF3	chr1	150294041	+	MRPS21	chr1	150280482	+
89113	STAD	TCGA-BR-8295-01A	RCC1	chr1	28834672	+	MRPS21	chr1	150280482	+
89113	STAD	TCGA-BR-8295-01A	SNHG3	chr1	28834672	+	MRPS21	chr1	150280482	+
89116	PRAD	TCGA-CH-5750-01A	TARS2	chr1	150463201	+	MRPS21	chr1	150280482	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRP	MRPS21	0.0193018786137342	0.54
KIRC	MRPS21	0.0227135612996884	0.61
THCA	MRPS21	0.0493457767952662	1

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUAD	MRPS21	0.013391390274936	0.43
LUSC	MRPS21	0.0393146291135188	1
LGG	MRPS21	0.0195853936861594	0.61
PAAD	MRPS21	0.0488583347561685	1
SKCM	MRPS21	0.0473888247794192	1
ACC	MRPS21	0.0324126848610837	0.97
COAD	MRPS21	0.00766878082171019	0.25

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source