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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: MTRF1L (NCBI Gene ID:54516)

Gene Summary

Gene Summary

Gene Information	Gene Name: MTRF1L
	Gene ID: 54516
	Gene Symbol	MTRF1L
	Gene ID	54516
	Gene Name	mitochondrial translational release factor 1 like
	Synonyms	HMRF1L\|MRF1L\|mtRF1a
	Cytomap	6q25.2
	Type of Gene	protein-coding
	Description	peptide chain release factor 1-like, mitochondrialmitochondrial release factor 1 like
	Modification date	20200320
	UniProtAcc	Q9UGC7

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0006415	Translational termination
GO:0032543	Mitochondrial translation
GO:0008135	Translation factor activity, RNA binding
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
MTRF1L	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'MTRF1L[title] AND translation [title] AND human.'

Gene	Title	PMID
MTRF1L	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000367233	153312319	153312456	Frame-shift
ENST00000367233	153316270	153316454	Frame-shift

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
KIRP	MTRF1L	-1.31576362507347	0.000177780166268349
COAD	MTRF1L	-1.15162723948358	0.000411599874496461
KICH	MTRF1L	-2.04766510138049	5.38825988769531e-05

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
UCEC	MTRF1L	0.201268317	0.012668986
LUAD	MTRF1L	0.168630506	0.03138634
CHOL	MTRF1L	0.064226132	0.048401541

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with MTRF1L (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
UVM	Cell metabolism gene	MTRF1L	PDE10A	0.813418952	4.86E-20
UVM	Cell metabolism gene	MTRF1L	NUP43	0.868767323	1.61E-25
UVM	CGC	MTRF1L	BCLAF1	0.808313978	1.26E-19
UVM	CGC	MTRF1L	GOPC	0.814353613	4.07E-20
UVM	Epifactor	MTRF1L	MAP3K7	0.805490484	2.10E-19
UVM	Epifactor	MTRF1L	ASF1A	0.816281174	2.82E-20
UVM	IUPHAR	MTRF1L	MAP3K7	0.805490484	2.10E-19
UVM	IUPHAR	MTRF1L	PDE10A	0.813418952	4.86E-20
UVM	IUPHAR	MTRF1L	KATNA1	0.823284738	7.14E-21
UVM	IUPHAR	MTRF1L	IFNGR1	0.843214769	1.00E-22
UVM	Kinase	MTRF1L	MAP3K7	0.805490484	2.10E-19
UVM	TF	MTRF1L	ZUFSP	0.835615391	5.45E-22
UVM	TSG	MTRF1L	SOD2	0.827081411	3.30E-21

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
STAD	MTRF1L	MTIF2	-1.91099017365555	0.000110303983092308
KIRC	MTRF1L	MRPL20	1.48585631024503	0.000111704804180407
PRAD	MTRF1L	MTIF2	-2.91163945232732	0.000148819683073472
HNSC	MTRF1L	C6orf211	-1.32760064373032	0.000172794781747143
LIHC	MTRF1L	C12orf65	-2.08973191928867	0.000217985677424833
THCA	MTRF1L	GFM2	1.24335152208863	0.000405886158765646
LUAD	MTRF1L	MRPL20	-3.00071204707904	0.000452706327224566
BLCA	MTRF1L	C12orf65	-2.39674217236397	0.000522613525390625
THCA	MTRF1L	MTIF2	1.01909960064239	0.00052377205169468
BRCA	MTRF1L	MRPL20	-1.74379528461375	0.000756034430433012
KICH	MTRF1L	MRRF	1.86992130954506	0.0014527440071106
LIHC	MTRF1L	MRPS7	1.27029395477208	0.00182077236082954
LUAD	MTRF1L	RMND1	-1.50506642526133	0.00200698412741262
COAD	MTRF1L	C12orf65	-1.9237597725242	0.0021815299987793
HNSC	MTRF1L	C12orf65	-1.25014898181687	0.00315447678462988
CHOL	MTRF1L	RMND1	-5.51835812536395	0.00390625
KIRP	MTRF1L	GFM2	-3.00163848603689	0.0044123362749815
THCA	MTRF1L	C12orf65	1.47165202177965	0.00833922528907868
PRAD	MTRF1L	ICT1	-1.54848444909352	0.00907723161841939
LUSC	MTRF1L	GFM2	-1.44135486663635	0.00981186007251347
PRAD	MTRF1L	C12orf65	-2.76087177223854	0.0112038296450184
LIHC	MTRF1L	MRPL20	-1.08735154161025	0.0158079482509981
KIRC	MTRF1L	MTIF2	-1.30575511475086	0.0182888755834972
LIHC	MTRF1L	MRRF	-1.19805818879659	0.0305924082275009
BLCA	MTRF1L	RMND1	-1.2684808234194	0.040130615234375
ESCA	MTRF1L	HEMK1	2.85895847440547	0.0419921875
BRCA	MTRF1L	ICT1	-4.17488220449664	2.73719348917167e-14
PRAD	MTRF1L	MRRF	-1.56810957454655	2.74398347191128e-05
HNSC	MTRF1L	HEMK1	2.17893783576508	3.37195160682314e-10
KIRC	MTRF1L	C12orf65	-5.50158310991918	3.4073920992543e-08
KIRC	MTRF1L	GFM2	-2.05005965144326	3.97470828213212e-07
KIRC	MTRF1L	HEMK1	1.74373279991111	3.99569143594996e-08
LUAD	MTRF1L	MTIF2	-5.14356588709714	3.996080695583e-11
LUSC	MTRF1L	ICT1	-3.23093376049456	6.60526357089358e-07
LUAD	MTRF1L	GFM2	-3.28752735953651	9.23397908905824e-05
BRCA	MTRF1L	MRPS7	-2.12787460270434	9.33194208595055e-10

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with MTRF1L

CHI3L1, HEMK1, MECR, PRPSAP2, ACAD9, MRM1, PDK1, TRMT61B, PDS5B, PDIA6, C21orf33, C6orf203, GFM1, MDH2, MRPS26, MRRF, MTIF2, MTRF1, AARS2, ABCB7, ACADM, ACADVL, ACAT1, ACOT1, ACOT2, AFG3L2, AK4, ALAS1, ALDH4A1, ATP5B, ATPIF1, ATP5J2-PTCD1, ATP5F1, ATP5J, ATPAF1, BCKDHA, BCS1L, C17orf80, CARS2, CDK5RAP1, CENPV, CLPX, COQ5, ADCK4, COX4I1, COX5A, CRYZ, CS, DAP3, DARS2, DBT, DHTKD1, DHX30, DLAT, DLST, EARS2, ECHS1, ECSIT, ELAC2, ERAL1, ETFA, ETFB, FASTKD2, FASTKD5, FECH, GADD45GIP1, GATB, GCDH, GLS, GLUD1, GRPEL1, GRSF1, GTPBP10, GTPBP3, GTPBP6, GUF1, HADH, HADHA, HARS2, HINT2, HNRNPL, HSD17B10, HSDL2, HSPA9, HSPE1, IARS2, IBA57, KIAA0391, LARS2, LETM1, LONP1, LRPPRC, LYRM4, LYRM7, ME2, MGME1, MMAB, RNMTL1, MRPL1, MRPL10, MRPL12, MRPL13, MRPL15, MRPL16, MRPL17, MRPL19, MRPL2, MRPL20, MRPL21, MRPL22, MRPL23, MRPL24, MRPL27, MRPL28, MRPL3, MRPL30, MRPL37, MRPL38, MRPL39, MRPL4, MRPL40, MRPL41, MRPL42, MRPL43, MRPL44, MRPL45, MRPL46, MRPL47, MRPL48, MRPL49, MRPL50, MRPL51, MRPL52, MRPL53, MRPL54, MRPL55, ICT1, MRPL9, MRPS10, MRPS11, MRPS14, MRPS16, MRPS17, MRPS18A, MRPS18B, MRPS18C, MRPS2, MRPS22, MRPS23, MRPS24, MRPS25, MRPS27, MRPS28, MRPS30, MRPS31, MRPS33, MRPS34, MRPS35, MRPS36, MRPS5, MRPS6, MRPS7, MRPS9, MTERF3, MTPAP, NDUFA12, NDUFA2, NDUFA5, NDUFA6, NDUFA7, NDUFA9, NDUFAF1, NDUFAF2, NDUFAF4, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, NFS1, NIPSNAP1, NME4, NNT, NOA1, NT5DC2, NUDT19, OAT, OGDH, PAM16, PDE12, PDHA1, PDHB, PDHX, PDK3, PDPR, PNPT1, POLDIP2, POLG, POLRMT, PPA2, PPIF, PREPL, PTCD3, PYCR1, PYCR2, QRSL1, RARS2, RTN4IP1, SARS2, SDHA, ACN9, SHMT2, SLIRP, STOML2, SUCLA2, SUPV3L1, TACO1, TARS2, TEFM, THEM4, TIMM44, TIMMDC1, TRMT10C, TRMT5, C10orf2, UQCC1, VARS2, VWA8, PMPCA, PMPCB, SSBP1, TSFM, CLPP, TRAP1, TTC4,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
MTRF1L	UCEC	chr6	153316347	153316347	T	C	Missense_Mutation	p.I149M	3
MTRF1L	BRCA	chr6	153315705	153315705	C	G	Missense_Mutation	p.K210N	3
MTRF1L	ESCA	chr6	153311100	153311100	T	C	Missense_Mutation	p.E358G	3
MTRF1L	KIRP	chr6	153315714	153315714	C	G	Missense_Mutation	p.K207N	3
MTRF1L	COAD	chr6	153311147	153311147	C	T	Silent	p.T342T	3
MTRF1L	PAAD	chr6	153315696	153315696	G	A	Silent	p.R213R	3
MTRF1L	ACC	chr6	153323806	153323806	A	G	Silent	p.V5V	3
MTRF1L	COAD	chr6	153315778	153315778	C	-	Frame_Shift_Del	p.G186fs	3
MTRF1L	BLCA	chr6	153316427	153316427	C	A	Nonsense_Mutation	p.E123*	3
MTRF1L	HNSC	chr6	153316432	153316432	G	A	Missense_Mutation	p.S121L	2
MTRF1L	ESCA	chr6	153310937	153310937	A	-	RNA	NULL	2
MTRF1L	STAD	chr6	153315697	153315697	C	T	Missense_Mutation	p.R213H	2
MTRF1L	UCEC	chr6	153311075	153311075	G	A	Silent	p.Y366	2
MTRF1L	ESCA	chr6	153311100	153311100	T	C	Missense_Mutation		2
MTRF1L	STAD	chr6	153311082	153311082	T	C	Missense_Mutation	p.K364R	2
MTRF1L	UCEC	chr6	153316342	153316342	T	C	Missense_Mutation	p.D151G	2
MTRF1L	LIHC	chr6	153323592	153323592	C	-	Frame_Shift_Del	p.E77fs	2
MTRF1L	PAAD	chr6	153315696	153315696	G	A	Silent		2
MTRF1L	LIHC	chr6	153312343	153312343	T	-	Frame_Shift_Del	p.R307fs	2
MTRF1L	LIHC	chr6	153316292	153316292	C	-	Frame_Shift_Del	p.E168fs	2
MTRF1L	PRAD	chr6	153319711	153319711	T	G	Missense_Mutation	p.K105Q	2
MTRF1L	COAD	chr6	153319702	153319702	T	A	Missense_Mutation	p.T108S	1
MTRF1L	LIHC	chr6	153311126	153311126	A	-	Frame_Shift_Del	p.F349fs	1
MTRF1L	SARC	chr6	153323589	153323589	G	T	Missense_Mutation		1
MTRF1L	TGCT	chr6	153323668	153323668	C	T	Silent	p.A51A	1
MTRF1L	BLCA	chr6	153323592	153323592	C	A	Nonsense_Mutation	p.E77*	1
MTRF1L	LIHC	chr6	153316354	153316354	G	A	Missense_Mutation	p.S147L	1
MTRF1L	COAD	chr6	153323594	153323594	C	T	Missense_Mutation	p.R76Q	1
MTRF1L	LIHC	chr6	153316408	153316408	A	-	Frame_Shift_Del	p.L129fs	1
MTRF1L	HNSC	chr6	153311053	153311053	C	G	Missense_Mutation	p.E374Q	1
MTRF1L	SKCM	chr6	153314014	153314014	G	A	Silent	p.V261V	1
MTRF1L	LIHC	chr6	153316444	153316444	A	C	Missense_Mutation	p.L117R	1
MTRF1L	LIHC	chr6	153312414	153312414	T	-	Frame_Shift_Del	p.N283fs	1
MTRF1L	KIRC	chr6	153323724	153323724	G	A	Silent	p.L33L	1
MTRF1L	STAD	chr6	153311053	153311053	C	A	Nonsense_Mutation	p.E374X	1
MTRF1L	UCEC	chr6	153311075	153311075	G	A	Silent	p.Y366Y	1
MTRF1L	BRCA	chr6	153323806	153323806	A	G	Silent	p.V5	1
MTRF1L	LIHC	chr6	153316373	153316374	-	TT	Frame_Shift_Ins	p.E141fs	1
MTRF1L	LIHC	chr6	153313992	153313992	C	T	Missense_Mutation		1
MTRF1L	CESC	chr6	153315695	153315695	C	T	Missense_Mutation		1
MTRF1L	LIHC	chr6	153313995	153313995	T	C	Missense_Mutation	p.T268A	1
MTRF1L	LUSC	chr6	153311084	153311084	C	T	Silent	p.L363L	1
MTRF1L	KIRP	chr6	153315714	153315714	C	G	Missense_Mutation		1
MTRF1L	CESC	chr6	153310988	153310988	G	A	RNA	NULL	1
MTRF1L	LIHC	chr6	153316417	153316417	T	C	Missense_Mutation	p.E126G	1
MTRF1L	GBM	chr6	153314064	153314064	G	C	Missense_Mutation		1
MTRF1L	LUSC	chr6	153316325	153316325	C	G	Missense_Mutation	p.A157P	1
MTRF1L	KIRP	chr6	153316295	153316295	G	T	Missense_Mutation		1
MTRF1L	UCS	chr6	153315832	153315832	G	T	Missense_Mutation		1
MTRF1L	STAD	chr6	153323789	153323789	C	G	Missense_Mutation	p.R11P	1
MTRF1L	GBM	chr6	153315751	153315751	A	C	Missense_Mutation		1
MTRF1L	LGG	chr6	153312424	153312424	G	T	Missense_Mutation		1
MTRF1L	COAD	chr6	153311175	153311175	C	T	Missense_Mutation	p.R333Q	1
MTRF1L	STAD	chr6	153311232	153311232	T	C	Splice_Site	.	1
MTRF1L	HNSC	chr6	153311053	153311053	C	G	Missense_Mutation		1
MTRF1L	ACC	chr6	153315660	153315660	G	T	Silent	p.P225P	1
MTRF1L	LIHC	chr6	153313995	153313995	T	C	Missense_Mutation		1
MTRF1L	COAD	chr6	153315695	153315695	C	T	Missense_Mutation	p.V214I	1
MTRF1L	HNSC	chr6	153316432	153316432	G	A	Missense_Mutation		1
MTRF1L	STAD	chr6	153311053	153311053	C	A	Nonsense_Mutation	p.E374*	1
MTRF1L	LIHC	chr6	153315778	153315778	C	-	Frame_Shift_Del		1
MTRF1L	LIHC	chr6	153312325	153312325	T	-	Frame_Shift_Del	p.I313fs	1
MTRF1L	HNSC	chr6	153315835	153315835	T	C	Missense_Mutation		1
MTRF1L	SARC	chr6	153319696	153319696	G	T	Missense_Mutation		1
MTRF1L	STAD	chr6	153312324	153312324	A	T	Missense_Mutation	p.I313N	1
MTRF1L	ACC	chr6	153315693	153315693	G	C	Silent	p.V214V	1
MTRF1L	LIHC	chr6	153316408	153316408	A	-	Frame_Shift_Del		1
MTRF1L	COAD	chr6	153316326	153316326	A	G	Silent	p.Y156Y	1
MTRF1L	LIHC	chr6	153311058	153311058	A	-	Frame_Shift_Del	p.L372fs	1
MTRF1L	HNSC	chr6	153323624	153323624	G	A	Missense_Mutation	p.A66V	1
MTRF1L	SARC	chr6	153312371	153312371	G	T	Missense_Mutation		1
MTRF1L	STAD	chr6	153315653	153315653	T	C	Missense_Mutation	p.T228A	1
MTRF1L	LIHC	chr6	153319755	153319755	T	C	Missense_Mutation		1

Copy number variation (CNV) of MTRF1L
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across MTRF1L
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
70471	UCEC	TCGA-D1-A3DH-01A	PTPRK	chr6	128718711	-	MTRF1L	chr6	153312456	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type

Translation factor

pval

adj.p

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	MTRF1L	0.0420563209438165	1
KICH	MTRF1L	0.0289705189094118	0.9
PRAD	MTRF1L	0.00523783960162223	0.17
THYM	MTRF1L	0.0102080024360811	0.33

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source