Home

Download

Statistics

Examples

Help

Contact

	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: CDKAL1 (NCBI Gene ID:54901)

Gene Summary

Gene Summary

Gene Information	Gene Name: CDKAL1
	Gene ID: 54901
	Gene Symbol	CDKAL1
	Gene ID	54901
	Gene Name	CDK5 regulatory subunit associated protein 1 like 1
	Synonyms	-
	Cytomap	6p22.3
	Type of Gene	protein-coding
	Description	threonylcarbamoyladenosine tRNA methylthiotransferasetRNA-t(6)A37 methylthiotransferase
	Modification date	20200322
	UniProtAcc	Q5VV42

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:1990145	Maintenance of translational fidelity
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
CDKAL1	>1119.25

Top

Translation Studies in PubMed

We searched PubMed using 'CDKAL1[title] AND translation [title] AND human.'

Gene	Title	PMID
CDKAL1	.	.

Top

Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000274695	20548823	20548936	Frame-shift
ENST00000378610	20548823	20548936	Frame-shift
ENST00000274695	20739749	20739846	Frame-shift
ENST00000378610	20739749	20739846	Frame-shift
ENST00000274695	20758825	20758874	Frame-shift
ENST00000378610	20758825	20758874	Frame-shift
ENST00000274695	20781375	20781496	Frame-shift
ENST00000378610	20781375	20781496	Frame-shift
ENST00000274695	20846305	20846409	Frame-shift
ENST00000378610	20846305	20846409	Frame-shift
ENST00000274695	20955649	20955816	Frame-shift
ENST00000378610	20955649	20955816	Frame-shift
ENST00000274695	21065278	21065459	Frame-shift
ENST00000378610	21065278	21065459	Frame-shift
ENST00000274695	21108631	21108694	In-frame
ENST00000378610	21108631	21108694	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000378610	21108631	21108694	3132	1247	1309	579	412	433
ENST00000274695	21108631	21108694	3289	1404	1466	579	412	433

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
Q5VV42	412	433	1	579	Chain	ID=PRO_0000298670;Note=Threonylcarbamoyladenosine tRNA methylthiotransferase
Q5VV42	412	433	1	579	Chain	ID=PRO_0000298670;Note=Threonylcarbamoyladenosine tRNA methylthiotransferase
Q5VV42	412	433	431	493	Domain	Note=TRAM;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00208
Q5VV42	412	433	431	493	Domain	Note=TRAM;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00208
Q5VV42	412	433	98	579	Alternative sequence	ID=VSP_027452;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q5VV42	412	433	98	579	Alternative sequence	ID=VSP_027452;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q5VV42	412	433	413	433	Alternative sequence	ID=VSP_027453;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q5VV42	412	433	413	433	Alternative sequence	ID=VSP_027453;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039

Top

Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
STAD	CDKAL1	-1.00173684517725	0.00779616041108966
COAD	CDKAL1	-4.01189329847879	2.27093696594239e-05
KICH	CDKAL1	2.6318615601118	2.98023223876953e-07
LIHC	CDKAL1	-1.87384347097153	4.62753391308183e-05

Top

Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
LGG	CDKAL1	3	2	0.0353624383295725	0.623939122193059	0.565321961222968	-0.816536491911975	-0.928663392157178

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
LAML	CDKAL1	0.072997635	0.003885746

Top

Associated Genes

Strongly correlated genes belong to cellular important gene groups with CDKAL1 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
KICH	Cell metabolism gene	CDKAL1	CDK19	0.833462095	1.19E-24
KICH	Cell metabolism gene	CDKAL1	SSR1	0.844438109	7.38E-26
KICH	Cell metabolism gene	CDKAL1	POLR3C	0.867071871	1.13E-28
KICH	CGC	CDKAL1	ARNT	0.816220148	6.40E-23
KICH	CGC	CDKAL1	SPOP	0.816602391	5.88E-23
KICH	CGC	CDKAL1	SMARCE1	0.857798694	1.84E-27
KICH	Epifactor	CDKAL1	TADA2A	0.804933127	6.97E-22
KICH	Epifactor	CDKAL1	HDAC2	0.808307261	3.47E-22
KICH	Epifactor	CDKAL1	DDX50	0.814029284	1.03E-22
KICH	Epifactor	CDKAL1	SPOP	0.816602391	5.88E-23
KICH	Epifactor	CDKAL1	ANP32E	0.824207511	1.07E-23
KICH	Epifactor	CDKAL1	SMARCE1	0.857798694	1.84E-27
KICH	IUPHAR	CDKAL1	SLC12A1	0.8008667	1.59E-21
KICH	IUPHAR	CDKAL1	RIOK1	0.802893946	1.06E-21
KICH	IUPHAR	CDKAL1	HDAC2	0.808307261	3.47E-22
KICH	IUPHAR	CDKAL1	KCNJ16	0.825788877	7.40E-24
KICH	IUPHAR	CDKAL1	CDK19	0.833462095	1.19E-24
KICH	IUPHAR	CDKAL1	LEPR	0.836628159	5.46E-25
KICH	IUPHAR	CDKAL1	NEK11	0.841555231	1.56E-25
KICH	Kinase	CDKAL1	RIOK1	0.802893946	1.06E-21
KICH	Kinase	CDKAL1	CDK19	0.833462095	1.19E-24
KICH	Kinase	CDKAL1	NEK11	0.841555231	1.56E-25
KICH	TF	CDKAL1	ZNF157	0.800784934	1.61E-21
KICH	TF	CDKAL1	FOXJ1	0.805735141	5.91E-22
KICH	TF	CDKAL1	ARNT	0.816220148	6.40E-23
KICH	TF	CDKAL1	ZNF883	0.819865975	2.86E-23
KICH	TF	CDKAL1	ZNF286A	0.828181264	4.23E-24
KICH	TSG	CDKAL1	SPOP	0.816602391	5.88E-23
KICH	TSG	CDKAL1	IFT88	0.842250102	1.31E-25

Top

Protein structure

Protein 3D structure
Visit iCn3D.

Top

Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
THCA	CDKAL1	SLC30A8	-5.48549098221525	0.00056968551756399
KIRP	CDKAL1	TCF7L2	1.8045315159091	0.000713176093995571
KICH	CDKAL1	TCF7L2	2.05992847043524	0.00071495771408081
ESCA	CDKAL1	TCF7L2	1.94753062243595	0.0009765625
KICH	CDKAL1	HHEX	1.22931304469288	0.00115483999252319
COAD	CDKAL1	HHEX	2.0550816882656	0.00144392251968384
KICH	CDKAL1	CDC123	1.1281353779398	0.00162535905838013
PRAD	CDKAL1	SLC30A8	1.00800975386359	0.00238744269754357
LIHC	CDKAL1	IGF2BP2	-1.28251900150286	0.00251545393492315
BLCA	CDKAL1	HHEX	3.49040697403827	0.00457763671875
LIHC	CDKAL1	TCF7L2	-3.98590148935441	0.00576533190924774
ESCA	CDKAL1	IGF2BP2	1.44682845104602	0.0068359375
KIRP	CDKAL1	KCNJ11	1.24203990666051	0.0105091729201376
HNSC	CDKAL1	SLC30A8	1.329864798739	0.0264612996081802
READ	CDKAL1	KCNJ11	-2.5858808600454	0.03125
THCA	CDKAL1	IGF2BP2	2.42715375485149	1.38653386544158e-06
LIHC	CDKAL1	CDC123	-2.92862307983694	1.46209952156891e-05
BRCA	CDKAL1	KCNJ11	1.20560306329836	2.10058486658397e-08
LIHC	CDKAL1	KCNJ11	-3.05859669731305	2.46746298874691e-06
LUAD	CDKAL1	CDC123	-3.82335348019155	2.73397811103595e-07
BRCA	CDKAL1	FTO	-2.09494010696594	3.14552302519821e-23
LUAD	CDKAL1	TCF7L2	-3.250082039967	3.14839627300049e-06
LUAD	CDKAL1	HHEX	-1.61385329451205	3.26900449389208e-06
LUSC	CDKAL1	IGF2BP2	2.77938194008141	3.28251669457867e-08
KIRP	CDKAL1	SLC30A8	-4.2922764128401	4.20957803726197e-07
KIRC	CDKAL1	FTO	1.08234124384934	4.81926317698848e-12
BRCA	CDKAL1	IGF2BP2	2.4784987517047	5.24897986361232e-23
KICH	CDKAL1	KCNJ11	2.25545798446479	5.38825988769531e-05
BRCA	CDKAL1	SLC30A8	1.91761932985321	6.90801621905167e-06

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with CDKAL1

ELAVL1, MMS19, LMNA, FAM96B, CIAO1, LCK, SUZ12, TCTN2, TCTN3, EVC2, NEK8, TMEM237, TMEM17, TMEM216, Mms19, FAF2, TTYH3, BPIFB1, DNM1, TYW3, DNM3, TYW1B, TRIM14, EGLN3, RIPK4, ESR2, CANX, LAMP1, PTRH2, NRAS, KRAS, NR2C2, HIST1H4A, P2RY6, UNC93B1, CA9, ACPP, TPTE, RHBDD1, RHBDF2, LMBR1L, FAM105A, SYVN1, CTBP2, PLEKHA4, nsp2, E, M, nsp4, nsp6, ORF14, ORF3a, ORF6, ORF7a, ORF7b, ORF8, S, nsp3, HSCB, ST7, TOP3B, BRD1, TRIM66, TRIM54, FIS1, FKBP8, HAX1, PTPN1, RHOT2, RMDN3, SLC25A46, Rnf183, E5, E5b, NPC1, FAM20C, DNAJC14, DNAJC16, DNAJC1, DNAJC25, SEC63, MARCH4, MARCH8, RNF139, ZNRF4, OGT, DDRGK1, ACBD5, ANAPC2, ARF6, ATP2A1, B3GAT1, BCAP31, CKAP4, CXADR, CYP2C9, DERL1, DHFRL1, ELOVL5, EMD, ERGIC1, ERGIC2, GJA1, GJD3, GORASP1, HSD17B11, HSD3B7, LAMP2, LAMP3, LMAN1, LMNB1, KIAA1715, LRRC59, MAPRE1, MARCKS, METTL7A, NUP155, PANX1, PXMP2, RAB11A, RAB35, RAB3B, RAB4A, RAB5A, RAB5C, RAB9A, REEP5, RPN1, RPN2, SEC61B, SEC62, SSR1, STIM1, STX4, STX6, STX7, SYNE3, TMPO, BTN2A1, LRRTM1, SPINT2, EDAR, UPRT, EVA1C, DNM2, CDK2, MFSD4, NAA10, AQP3, TMEM9B, PIGH, USO1, HDLBP, ASB14, HLA-C, ACVR2B, EVA1B, INSRR, STK25, ITLN1, P2RY8, RAP1B, C9orf91, AMHR2, PCDHB3, FAM96A, TMEM106A, ALCAM, GSTK1, LETM1, BTN3A1, NAA50, CCDC107, TMEM63A, FFAR1, LGR4, C3orf52, SCAP, CYP19A1, TMPRSS2, DPP4, TMPRSS11B, TMPRSS4, CLEC4E,

Top

Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
CDKAL1	chr6	20546697	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
CDKAL1	chr6	20649534	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
CDKAL1	chr6	20661034	A	C	single_nucleotide_variant	Uncertain_significance	Type_2_diabetes_mellitus	SO:0001627\|intron_variant	SO:0001627\|intron_variant
CDKAL1	chr6	20661250	G	C	single_nucleotide_variant	risk_factor	Obesity	SO:0001627\|intron_variant	SO:0001627\|intron_variant
CDKAL1	chr6	20679709	A	G	single_nucleotide_variant	Uncertain_significance	Type_2_diabetes_mellitus	SO:0001627\|intron_variant	SO:0001627\|intron_variant
CDKAL1	chr6	20781449	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
CDKAL1	chr6	21198307	A	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
CDKAL1	chr6	21231073	T	TTA	Microsatellite	Likely_benign	not_provided	SO:0001574\|splice_acceptor_variant	SO:0001574\|splice_acceptor_variant
CDKAL1	chr6	21231075	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
CDKAL1	chr6	21231222	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
CDKAL1	BLCA	chr6	21231097	21231097	G	A	Missense_Mutation	p.G523R	5
CDKAL1	PAAD	chr6	20546630	20546630	G	A	Missense_Mutation	p.V17M	5
CDKAL1	BLCA	chr6	21201493	21201493	G	A	Silent		4
CDKAL1	KIRP	chr6	20548882	20548882	T	G	Missense_Mutation	p.S78A	4
CDKAL1	KIRP	chr6	20846322	20846322	A	G	Missense_Mutation	p.T219A	4
CDKAL1	PAAD	chr6	20546630	20546630	G	A	Missense_Mutation		4
CDKAL1	LUAD	chr6	21065370	21065370	G	C	Missense_Mutation	p.E383Q	3
CDKAL1	PAAD	chr6	20781393	20781393	C	T	Silent	p.L179L	3
CDKAL1	LIHC	chr6	20548862	20548862	G	-	Frame_Shift_Del	p.W71fs	3
CDKAL1	SKCM	chr6	20781484	20781484	C	T	Missense_Mutation	p.S209F	3
CDKAL1	BLCA	chr6	20846385	20846385	G	A	Missense_Mutation	p.D240N	3
CDKAL1	ESCA	chr6	21065322	21065322	C	T	Missense_Mutation	p.P367S	3
CDKAL1	LUAD	chr6	20758841	20758841	C	T	Missense_Mutation	p.R162C	3
CDKAL1	UCEC	chr6	20955656	20955656	T	C	Missense_Mutation	p.V250A	3
CDKAL1	BRCA	chr6	21201369	21201369	T	G	Missense_Mutation	p.M471R	3
CDKAL1	UCEC	chr6	21231175	21231175	A	G	Missense_Mutation	p.M549V	3
CDKAL1	SKCM	chr6	21065457	21065457	G	A	Missense_Mutation	p.V412M	2
CDKAL1	UCEC	chr6	21065312	21065312	C	A	Silent	p.I363	2
CDKAL1	TGCT	chr6	21065449	21065449	C	T	Missense_Mutation		2
CDKAL1	BLCA	chr6	21201376	21201376	G	C	Missense_Mutation	p.K473N	2
CDKAL1	UCEC	chr6	21198326	21198326	C	A	Missense_Mutation	p.F458L	2
CDKAL1	TGCT	chr6	21065450	21065450	A	G	Silent		2
CDKAL1	UCEC	chr6	21201394	21201394	C	A	Silent	p.I479	2
CDKAL1	SKCM	chr6	21198298	21198298	C	T	Missense_Mutation	p.S449F	2
CDKAL1	UCEC	chr6	20546588	20546588	T	C	Missense_Mutation	p.S3P	2
CDKAL1	UCEC	chr6	21201492	21201492	C	T	Missense_Mutation	p.S512L	2
CDKAL1	SARC	chr6	20781386	20781386	G	C	Silent		2
CDKAL1	SKCM	chr6	20739777	20739777	C	T	Silent	p.I133I	2
CDKAL1	STAD	chr6	20846367	20846367	C	G	Missense_Mutation	p.P234A	2
CDKAL1	UCEC	chr6	20758843	20758843	T	C	Silent	p.R162	2
CDKAL1	SKCM	chr6	21201483	21201483	G	A	Missense_Mutation	p.G509E	2
CDKAL1	ESCA	chr6	21065322	21065322	C	T	Missense_Mutation		2
CDKAL1	STAD	chr6	21000460	21000460	A	T	Missense_Mutation	p.E304D	2
CDKAL1	THYM	chr6	20955725	20955725	C	A	Missense_Mutation		2
CDKAL1	UCEC	chr6	20781474	20781474	G	T	Nonsense_Mutation	p.E206*	2
CDKAL1	KIRC	chr6	20781422	20781422	G	C	Silent	p.R188R	2
CDKAL1	SKCM	chr6	20649538	20649538	G	T	Missense_Mutation	p.A101S	2
CDKAL1	STAD	chr6	21201396	21201396	A	G	Missense_Mutation	p.Y480C	2
CDKAL1	UCEC	chr6	20781494	20781494	C	T	Silent	p.T212	2
CDKAL1	KIRC	chr6	21231246	21231246	T	-	Frame_Shift_Del	p.A572fs	2
CDKAL1	ACC	chr6	21000542	21000542	G	T	Nonsense_Mutation	p.E332X	2
CDKAL1	UCEC	chr6	20846376	20846376	G	T	Nonsense_Mutation	p.E237*	2
CDKAL1	LIHC	chr6	21108646	21108646	A	-	Frame_Shift_Del	p.T417fs	2
CDKAL1	UCEC	chr6	20955720	20955720	C	T	Silent	p.L271	2
CDKAL1	CESC	chr6	20649602	20649602	C	T	Missense_Mutation		2
CDKAL1	LUAD	chr6	21108643	21108643	G	C	Missense_Mutation	p.R416S	2
CDKAL1	BLCA	chr6	21065357	21065357	G	A	Silent	p.V378V	2
CDKAL1	KIRP	chr6	20739778	20739778	G	C	Missense_Mutation	p.V134L	2
CDKAL1	UCEC	chr6	20955791	20955791	C	T	Missense_Mutation	p.P295L	2
CDKAL1	PAAD	chr6	20781393	20781393	C	T	Silent		2
CDKAL1	STAD	chr6	21108632	21108632	A	-	Splice_Site	p.K413_splice	2
CDKAL1	KIRP	chr6	20548882	20548882	T	G	Missense_Mutation		1
CDKAL1	UCEC	chr6	21231240	21231245	TTTTGC	-	In_Frame_Del	p.FA571del	1
CDKAL1	COAD	chr6	20546605	20546605	A	C	Silent	p.T8T	1
CDKAL1	LIHC	chr6	20781401	20781402	-	A	Frame_Shift_Ins	p.QK181fs	1
CDKAL1	SKCM	chr6	20781397	20781397	G	T	Missense_Mutation	p.G180V	1
CDKAL1	BLCA	chr6	21201376	21201376	G	C	Missense_Mutation		1
CDKAL1	HNSC	chr6	21000492	21000492	A	C	Missense_Mutation		1
CDKAL1	KIRP	chr6	20846322	20846322	A	G	Missense_Mutation		1
CDKAL1	SKCM	chr6	20649552	20649552	C	G	Silent	p.L105L	1
CDKAL1	UCEC	chr6	21231245	21231246	-	T	Frame_Shift_Ins	p.A572fs	1
CDKAL1	COAD	chr6	21065450	21065450	A	G	Silent	p.P409P	1
CDKAL1	LUSC	chr6	20546619	20546619	T	C	Missense_Mutation	p.I13T	1
CDKAL1	SKCM	chr6	21231213	21231213	C	T	Silent	p.S561S	1
CDKAL1	BLCA	chr6	20649569	20649570	-	-	Frame_Shift_Ins		1
CDKAL1	HNSC	chr6	21000493	21000493	C	T	Silent		1
CDKAL1	BLCA	chr6	21198321	21198321	C	G	Missense_Mutation	p.Q457E	1
CDKAL1	LGG	chr6	21201422	21201422	G	A	Missense_Mutation	p.G489R	1
CDKAL1	UCEC	chr6	21065431	21065432	-	A	Frame_Shift_Ins	p.A403fs	1
CDKAL1	COAD	chr6	21231214	21231214	G	A	Missense_Mutation	p.V562M	1
CDKAL1	LIHC	chr6	21065432	21065432	A	-	Frame_Shift_Del	p.A403fs	1
CDKAL1	LUSC	chr6	20955785	20955785	C	T	Missense_Mutation	p.T293I	1
CDKAL1	STAD	chr6	21000533	21000533	G	A	Missense_Mutation		1
CDKAL1	HNSC	chr6	20846391	20846391	G	A	Missense_Mutation	p.A242T	1
CDKAL1	READ	chr6	20955687	20955687	G	A	Silent	p.T260T	1
CDKAL1	THCA	chr6	20955687	20955687	G	T	Silent		1
CDKAL1	LGG	chr6	20846359	20846359	C	T	Missense_Mutation	p.A231V	1
CDKAL1	ESCA	chr6	20955679	20955679	G	T	Nonsense_Mutation	p.E258*	1
CDKAL1	LIHC	chr6	21231239	21231239	T	-	Frame_Shift_Del	p.L570fs	1
CDKAL1	LUSC	chr6	21201499	21201499	G	A	Silent	p.L514L	1
CDKAL1	STAD	chr6	21000533	21000533	G	A	Missense_Mutation	p.V329I	1
CDKAL1	BLCA	chr6	21198321	21198321	C	G	Missense_Mutation		1
CDKAL1	HNSC	chr6	21000493	21000493	C	T	Silent	p.Y315Y	1
CDKAL1	THCA	chr6	20955792	20955792	G	A	Silent		1
CDKAL1	BLCA	chr6	20758834	20758834	G	A	Silent	p.Q159Q	1
CDKAL1	LIHC	chr6	20649552	20649552	C	T	Silent		1
CDKAL1	LIHC	chr6	21065288	21065288	A	-	Frame_Shift_Del	p.G355fs	1
CDKAL1	LUSC	chr6	20955674	20955674	C	G	Missense_Mutation	p.T256S	1
CDKAL1	SARC	chr6	21000521	21000521	G	T	Missense_Mutation		1
CDKAL1	THCA	chr6	20955792	20955792	G	A	Silent	p.P295P	1
CDKAL1	BLCA	chr6	20846385	20846385	G	A	Missense_Mutation		1
CDKAL1	HNSC	chr6	21000492	21000492	A	C	Missense_Mutation	p.Y315S	1
CDKAL1	BLCA	chr6	21231200	21231200	C	T	Missense_Mutation	p.A557V	1
CDKAL1	LIHC	chr6	20781431	20781431	A	G	Silent		1
CDKAL1	LUSC	chr6	20548873	20548873	C	T	Missense_Mutation	p.H75Y	1
CDKAL1	SARC	chr6	21065347	21065347	A	G	Missense_Mutation		1
CDKAL1	BLCA	chr6	20758834	20758834	G	A	Silent		1
CDKAL1	BLCA	chr6	20781488	20781488	C	T	Silent	p.I210I	1
CDKAL1	LIHC	chr6	21065331	21065331	A	G	Missense_Mutation		1
CDKAL1	LUAD	chr6	20781382	20781382	C	T	Missense_Mutation	p.S175F	1
CDKAL1	ESCA	chr6	21201340	21201340	G	T	Splice_Site		1
CDKAL1	LUSC	chr6	20758859	20758859	G	A	Missense_Mutation	p.E168K	1
CDKAL1	SARC	chr6	21000494	21000494	G	T	Missense_Mutation		1
CDKAL1	THYM	chr6	21231178	21231178	C	T	Missense_Mutation	p.P550S	1
CDKAL1	BLCA	chr6	21231200	21231200	C	T	Missense_Mutation		1
CDKAL1	BLCA	chr6	20649569	20649570	-	A	Frame_Shift_Ins	p.VK111fs	1
CDKAL1	LIHC	chr6	21065331	21065331	A	G	Missense_Mutation	p.T370A	1
CDKAL1	SKCM	chr6	21108659	21108659	C	T	Missense_Mutation	p.R422W	1
CDKAL1	ESCA	chr6	21201340	21201340	G	T	Splice_Site	.	1
CDKAL1	OV	chr6	21065364	21065364	G	C	Missense_Mutation	p.V381L	1
CDKAL1	STAD	chr6	20546663	20546663	C	T	Missense_Mutation	p.H28Y	1
CDKAL1	SARC	chr6	20781386	20781386	G	C	Silent	p.V176V	1
CDKAL1	BLCA	chr6	20781488	20781488	C	T	Silent		1
CDKAL1	LUAD	chr6	21000597	21000597	A	G	Missense_Mutation	p.K350R	1
CDKAL1	SKCM	chr6	21000535	21000535	A	G	Silent	p.V329V	1
CDKAL1	ACC	chr6	21000542	21000542	G	T	Nonsense_Mutation	p.E332*	1
CDKAL1	ESCA	chr6	20955679	20955679	G	T	Nonsense_Mutation	p.E258X	1
CDKAL1	OV	chr6	20846328	20846328	T	A	Missense_Mutation	p.C221S	1
CDKAL1	STAD	chr6	21231094	21231094	C	T	Missense_Mutation	p.L522F	1
CDKAL1	SARC	chr6	21065347	21065347	A	G	Missense_Mutation	p.Q375R	1
CDKAL1	UCEC	chr6	21000464	21000464	G	T	Missense_Mutation	p.A306S	1
CDKAL1	BLCA	chr6	21231222	21231222	G	A	Silent		1
CDKAL1	LIHC	chr6	20846331	20846331	A	-	Frame_Shift_Del	p.C221X	1
CDKAL1	SKCM	chr6	21201505	21201505	G	A	Splice_Site	p.K516_splice	1
CDKAL1	BLCA	chr6	21065357	21065357	G	A	Silent		1
CDKAL1	ESCA	chr6	20781375	20781375	G	T	Splice_Site	.	1
CDKAL1	STAD	chr6	21065338	21065338	A	G	Missense_Mutation	p.Q372R	1
CDKAL1	SARC	chr6	20781386	20781386	G	C	Silent	p.V176	1
CDKAL1	CESC	chr6	20649602	20649602	C	T	Missense_Mutation	p.S122L	1
CDKAL1	LIHC	chr6	20758870	20758871	-	A	Frame_Shift_Ins	p.R172fs	1
CDKAL1	LUAD	chr6	20758835	20758835	A	G	Missense_Mutation	p.I160V	1
CDKAL1	SKCM	chr6	21108681	21108681	C	T	Missense_Mutation	p.P429L	1
CDKAL1	BLCA	chr6	21231097	21231097	G	A	Missense_Mutation		1
CDKAL1	GBM	chr6	20548856	20548856	G	A	Missense_Mutation		1

Copy number variation (CNV) of CDKAL1
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across CDKAL1
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
102349	N/A	EB387269	ALG13	chrX	110935423	+	CDKAL1	chr6	21171471	-
81633	LUSC	TCGA-33-4587-01A	CDKAL1	chr6	20846409	+	ASH1L	chr1	155349907	-
91658	N/A	AA885570	CDKAL1	chr6	20363814	-	C4orf50	chr4	5951652	+
100899	LUAD	TCGA-91-6847-01A	CDKAL1	chr6	20548936	+	C6orf89	chr6	36862280	+
68884	LUSC	TCGA-56-8307-01A	CDKAL1	chr6	20535625	+	CLCN4	chrX	10153062	+
22328	N/A	BP350154	CDKAL1	chr6	20548923	+	CNNM4	chr2	97427351	+
63897	LIHC	TCGA-G3-A7M5-01A	CDKAL1	chr6	21108694	+	CRHR2	chr7	30695628	-
100903	BLCA	TCGA-DK-AA6U	CDKAL1	chr6	20535625	+	DNAH8	chr6	38850685	+
100903	BLCA	TCGA-DK-AA6U-01A	CDKAL1	chr6	20535625	+	DNAH8	chr6	38850686	+
97182	ESCA	TCGA-JY-A6FH	CDKAL1	chr6	20739846	+	E2F3	chr6	20488343	+
97182	LUAD	TCGA-44-6778-01A	CDKAL1	chr6	20548936	+	E2F3	chr6	20480077	+
97182	LUSC	TCGA-66-2757	CDKAL1	chr6	20649608	+	E2F3	chr6	20480076	+
97870	LGG	TCGA-DH-A66G-01A	CDKAL1	chr6	20758874	-	EXOC2	chr6	576882	-
92900	STAD	TCGA-VQ-AA68-01A	CDKAL1	chr6	21065459	+	FARS2	chr6	5771524	+
98276	OV	TCGA-04-1331	CDKAL1	chr6	20548936	+	GMDS	chr6	1961200	-
98276	STAD	TCGA-HU-A4GN	CDKAL1	chr6	21065459	+	GMDS	chr6	1961200	-
31239	BLCA	TCGA-XF-AAN7-01A	CDKAL1	chr6	21000603	+	GUCA1A	chr6	42130658	+
80869	STAD	TCGA-FP-A4BF	CDKAL1	chr6	20548936	+	HIVEP3	chr1	42094618	-
101214	BRCA	TCGA-B6-A0RS-01A	CDKAL1	chr6	20535625	+	HSP90AA1	chr14	102568422	-
52409	BLCA	TCGA-E7-A7PW-01A	CDKAL1	chr6	20781496	+	IL22	chr12	68642656	-
87378	SARC	TCGA-DX-A48N-01A	CDKAL1	chr6	20548936	-	JARID2	chr6	15487538	+
97192	HNSC	TCGA-BA-A4II-01A	CDKAL1	chr6	20649608	-	KCNMB2	chr3	178525131	+
70159	N/A	AA687456	CDKAL1	chr6	20928942	+	KDELR1	chr19	48885832	+
42523	PRAD	TCGA-HC-7209	CDKAL1	chr6	20535625	+	KIF11	chr10	94366021	+
81967	BLCA	TCGA-ZF-A9RF-01A	CDKAL1	chr6	20649608	+	LIG1	chr19	48634428	-
83776	STAD	TCGA-BR-8364-01A	CDKAL1	chr6	20846409	+	MBNL1	chr3	152132730	+
102115	N/A	EC559801	CDKAL1	chr6	20601973	+	MICAL1	chr6	109786428	-
69429	SKCM	TCGA-WE-A8ZT-06A	CDKAL1	chr6	20548936	+	MICB	chr6	31473394	+
93501	N/A	FN103014	CDKAL1	chr6	20610003	-	MME	chr3	154767632	-
91301	BLCA	TCGA-DK-AA75-01A	CDKAL1	chr6	21108694	+	MSRB3	chr12	65881784	+
100796	STAD	TCGA-BR-8372-01A	CDKAL1	chr6	20548936	+	MTHFD2L	chr4	75091019	+
88887	N/A	BF089619	CDKAL1	chr6	21080105	+	MX2	chr21	42752068	-
101090	BLCA	TCGA-4Z-AA7R-01A	CDKAL1	chr6	20548936	+	OFCC1	chr6	9850702	-
93943	LUSC	TCGA-77-7142-01A	CDKAL1	chr6	20781496	+	OR2H1	chr6	29426231	+
100656	N/A	BQ717736	CDKAL1	chr6	21003461	+	PPP2R5C	chr14	102391037	+
102127	N/A	DN914804	CDKAL1	chr6	20634051	-	RAPGEF4	chr2	173655000	-
24781	BRCA	TCGA-B6-A0I6-01A	CDKAL1	chr6	20955816	+	RBM24	chr6	17291987	+
89604	BLCA	TCGA-GV-A3JZ-01A	CDKAL1	chr6	20781496	+	RCAN2	chr6	46424715	-
15359	BLCA	TCGA-XF-AAN7-01A	CDKAL1	chr6	21000603	-	RP1-139D8.6	chr6	42130658	+
15359	N/A	DX571701	CDKAL1	chr6	20564386	-	RP11-431K24.1	chr1	8153423	-
100465	OV	TCGA-13-1510-01A	CDKAL1	chr6	20548936	+	SMARCA2	chr9	2192704	+
89276	BLCA	TCGA-GV-A3JZ-01A	CDKAL1	chr6	20548936	+	TBC1D1	chr4	38091553	+
102349	N/A	AW580968	COL1A1	chr17	48262698	-	CDKAL1	chr6	21139955	+
102349	LUSC	TCGA-21-5787	DPY19L1	chr7	35029495	-	CDKAL1	chr6	21198251	+
102349	LUSC	TCGA-21-5787-01A	DPY19L1	chr7	35029496	-	CDKAL1	chr6	21198252	+
102349	BLCA	TCGA-E7-A7PW-01A	E2F3	chr6	20404063	+	CDKAL1	chr6	20846306	+
102349	BLCA	TCGA-G2-A2EF-01A	E2F3	chr6	20404063	+	CDKAL1	chr6	20546577	+
102349	BLCA	TCGA-YC-A9TC	E2F3	chr6	20404063	+	CDKAL1	chr6	20955650	+
102349	N/A	BG033509	ERH	chr14	69846848	-	CDKAL1	chr6	20948266	-
102349	BRCA	TCGA-OL-A5DA-01A	GRIK2	chr6	101847268	+	CDKAL1	chr6	21065279	+
102349	BLCA	TCGA-FD-A3SJ	HERC4	chr10	69792534	-	CDKAL1	chr6	21000457	+
102349	BLCA	TCGA-FD-A3SJ-01A	HERC4	chr10	69792535	-	CDKAL1	chr6	21000458	+
102349	BLCA	TCGA-XF-AAMG-01A	IRAK2	chr3	10242199	+	CDKAL1	chr6	20846306	+
102349	BLCA	TCGA-KQ-A41R-01A	JARID2	chr6	15410596	+	CDKAL1	chr6	20649524	+
102349	N/A	EC518035	LARP1B	chr4	128995310	-	CDKAL1	chr6	20597971	-
102349	BLCA	TCGA-E7-A7DV-01A	LCORL	chr4	18023221	-	CDKAL1	chr6	20955650	+
102349	STAD	TCGA-HU-A4H8	LGALS3	chr14	55596018	+	CDKAL1	chr6	20649523	+
102349	PRAD	TCGA-XJ-A9DX-01A	LRRC16A	chr6	25557078	-	CDKAL1	chr6	21198252	+
102349	STAD	TCGA-BR-8678-01A	MAPKBP1	chr15	42067587	+	CDKAL1	chr6	21000458	+
102349	LUSC	TCGA-43-6143-01A	MBOAT1	chr6	20115518	-	CDKAL1	chr6	20756998	-
102349	LUSC	TCGA-43-6143-01A	MBOAT1	chr6	20151415	-	CDKAL1	chr6	20971655	-
102349	LUSC	TCGA-43-6143-01A	MBOAT1	chr6	20151415	-	CDKAL1	chr6	20974430	-
102349	LUSC	TCGA-43-6143-01A	MBOAT1	chr6	20151415	-	CDKAL1	chr6	21000591	-
102349	LUSC	TCGA-43-6143-01A	MBOAT1	chr6	20154882	-	CDKAL1	chr6	21000602	-
102349	LUSC	TCGA-43-6143-01A	MBOAT1	chr6	20178923	-	CDKAL1	chr6	21000602	-
102349	LUSC	TCGA-43-6143-01A	MBOAT1	chr6	20212366	-	CDKAL1	chr6	21000591	-
102349	OV	TCGA-09-0367-01A	MBOAT1	chr6	20212366	-	CDKAL1	chr6	20632573	-
102349	STAD	TCGA-BR-8284	MBOAT1	chr6	20124638	-	CDKAL1	chr6	20649523	+
102349	STAD	TCGA-BR-8284-01A	MBOAT1	chr6	20124639	-	CDKAL1	chr6	20649524	+
102349	BLCA	TCGA-XF-AAMY-01A	METTL21B	chr12	58166856	+	CDKAL1	chr6	21198252	+
102349	STAD	TCGA-BR-A44T-01A	NEK4	chr3	52771602	-	CDKAL1	chr6	20535582	+
102349	OV	TCGA-24-2297	NUP153	chr6	17616757	-	CDKAL1	chr6	21198251	+
102349	BLCA	TCGA-DK-A1AD-01A	PPARG	chr3	12458653	+	CDKAL1	chr6	20649524	+
102349	BRCA	TCGA-EW-A1PF-01A	RANBP9	chr6	13697017	-	CDKAL1	chr6	20955650	+
102349	STAD	TCGA-BR-7722-01A	RHBDD1	chr2	227779067	+	CDKAL1	chr6	20955650	+
102349	SARC	TCGA-DX-AATS-01A	UBR2	chr6	42626562	+	CDKAL1	chr6	20548824	+
102350	BRCA	TCGA-C8-A26W	ZNF551	chr19	58193612	+	CDKAL1	chr6	20649523	+

Top

Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

Top

Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
TGCT	CDKAL1	0.00487420867743783	0.14
ACC	CDKAL1	0.00631354909038166	0.17
KIRP	CDKAL1	0.00733006070712703	0.19
HNSC	CDKAL1	0.00969847388690839	0.24
LUSC	CDKAL1	0.0121691652093122	0.29
BLCA	CDKAL1	0.031691599683835	0.73
GBM	CDKAL1	0.0369880694574419	0.81

Top

Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
BRCA	CDKAL1	1.86424838877453e-06	6.2e-05
UVM	CDKAL1	0.0106888618474183	0.32
PCPG	CDKAL1	0.00652608651790574	0.2
HNSC	CDKAL1	0.000381310014713806	0.012

Top

Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0011860	Diabetes Mellitus, Non-Insulin-Dependent	3	CTD_human
C0263859	Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis Syndrome	1	CTD_human