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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: SARS2 (NCBI Gene ID:54938)

Gene Summary

Gene Summary

Gene Information	Gene Name: SARS2
	Gene ID: 54938
	Gene Symbol	SARS2
	Gene ID	54938
	Gene Name	seryl-tRNA synthetase 2, mitochondrial
	Synonyms	SARS\|SARSM\|SERS\|SYS\|SerRS\|SerRSmt\|mtSerRS
	Cytomap	19q13.2
	Type of Gene	protein-coding
	Description	serine--tRNA ligase, mitochondrialmitochondrial seryl-tRNA synthetaseserine tRNA ligase 2, mitochondrialseryl-tRNA synthetase, mitochondrialseryl-tRNA(Ser/Sec) synthetase
	Modification date	20200313
	UniProtAcc	Q9NP81

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0032543	Mitochondrial translation
GO:0006418	tRNA aminoacylation for protein translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene

Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25

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Translation Studies in PubMed

We searched PubMed using 'SARS2[title] AND translation [title] AND human.'

Gene	Title	PMID
SARS2	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

ORF

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
LUAD	SARS2	-1.6825303693262	1.52668366875458e-07
KIRC	SARS2	1.02423405449982	8.65930768143138e-05

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
LAML	SARS2	3	2	0.0228643565341937	0.6634925	0.465762432065217	-0.8082095435024	-0.466982043503409

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
ESCA	SARS2	0.039894029	0.034925789

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with SARS2 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
READ	Cell metabolism gene	SARS2	TIMM50	0.807991321	2.10E-25
READ	Epifactor	SARS2	FBL	0.808379182	1.91E-25
TGCT	Cell metabolism gene	SARS2	SRM	0.809791324	1.72E-37
TGCT	Cell metabolism gene	SARS2	EXOSC5	0.86691093	2.01E-48
TGCT	Epifactor	SARS2	EXOSC5	0.86691093	2.01E-48
THYM	Cell metabolism gene	SARS2	NT5C	0.820127052	7.08E-31
THYM	IUPHAR	SARS2	NT5C	0.820127052	7.08E-31
UCS	Cell metabolism gene	SARS2	NT5C	0.820127052	7.08E-31
UCS	IUPHAR	SARS2	NT5C	0.820127052	7.08E-31
UVM	Cell metabolism gene	SARS2	PIK3R2	0.801185978	4.51E-19
UVM	Cell metabolism gene	SARS2	TIMM22	0.801449685	4.30E-19
UVM	Cell metabolism gene	SARS2	PRKCSH	0.804085764	2.70E-19
UVM	Cell metabolism gene	SARS2	POLD2	0.809956175	9.28E-20
UVM	Cell metabolism gene	SARS2	POLR2I	0.811507351	6.96E-20
UVM	Cell metabolism gene	SARS2	AAAS	0.811548739	6.90E-20
UVM	Cell metabolism gene	SARS2	TIMM13	0.834432085	7.04E-22
UVM	Cell metabolism gene	SARS2	PGLS	0.867200298	2.49E-25
UVM	CGC	SARS2	SMARCD1	0.808314821	1.26E-19
UVM	CGC	SARS2	MAP2K2	0.842572796	1.16E-22
UVM	Epifactor	SARS2	TRIM28	0.806552661	1.73E-19
UVM	Epifactor	SARS2	SMARCD1	0.808314821	1.26E-19
UVM	Epifactor	SARS2	CCDC101	0.830150439	1.75E-21
UVM	Epifactor	SARS2	RUVBL2	0.831420043	1.34E-21
UVM	Epifactor	SARS2	BRMS1	0.844971248	6.69E-23
UVM	IUPHAR	SARS2	PIK3R2	0.801185978	4.51E-19
UVM	IUPHAR	SARS2	TRIM28	0.806552661	1.73E-19
UVM	IUPHAR	SARS2	MAP2K2	0.842572796	1.16E-22
UVM	Kinase	SARS2	TRIM28	0.806552661	1.73E-19
UVM	Kinase	SARS2	MAP2K2	0.842572796	1.16E-22
UVM	TF	SARS2	ZNF787	0.805022954	2.28E-19
UVM	TF	SARS2	SNAPC2	0.805650841	2.04E-19
UVM	TF	SARS2	ZNF414	0.806202314	1.84E-19
UVM	TSG	SARS2	GADD45GIP1	0.805322976	2.16E-19
UVM	TSG	SARS2	TSSC4	0.810325156	8.67E-20
UVM	TSG	SARS2	BRMS1	0.844971248	6.69E-23

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
PRAD	SARS2	RARS	-3.26725599613282	0.000138268841223163
STAD	SARS2	LARS2	-3.14243034518345	0.00019507110118866
STAD	SARS2	YARS	-6.49411565641968	0.000280400272458792
KIRP	SARS2	PARS2	1.16452168188224	0.000471815001219511
HNSC	SARS2	YARS	1.29642872422682	0.000481783007217019
THCA	SARS2	LARS2	1.46480152873302	0.000495104848866816
STAD	SARS2	EPRS	-1.48171581324647	0.000789262883452143
LUSC	SARS2	RARS2	1.87851633718952	0.00105278618568408
BLCA	SARS2	PARS2	-2.53947468245316	0.002838134765625
HNSC	SARS2	YARS2	1.51758504797514	0.00498432417884942
KIRP	SARS2	RARS2	-1.62015129839089	0.00733334058895707
ESCA	SARS2	YARS2	-2.00710684466974	0.0185546875
STAD	SARS2	CARS	-3.1134898215181	0.0194480954669416
PRAD	SARS2	PARS2	-1.46158282673459	0.0436765184075403
PRAD	SARS2	CARS2	1.13713373330258	0.0476188245531179
BRCA	SARS2	CARS	-3.12549590231492	1.01520616166893e-06
LUAD	SARS2	PARS2	-3.49187010929807	1.06715530949094e-10
LUSC	SARS2	RARS	-4.20411207838574	1.09583750788394e-07
BRCA	SARS2	LARS2	-5.48583270161281	1.12177735729832e-06
THCA	SARS2	YARS	-1.52851760350795	1.38467683131598e-09
KIRC	SARS2	CARS	-2.26215465257439	1.77517968413055e-12
KIRP	SARS2	CARS	-1.01391921700556	2.26888805627823e-05
LIHC	SARS2	EPRS	-7.10731017811505	2.28054594243154e-08
LUAD	SARS2	LARS2	-1.17851720308655	2.81164525558733e-06
KICH	SARS2	YARS	-2.00632816869948	2.98023223876953e-07
LUSC	SARS2	PARS2	-2.93653902690081	3.1117120779415e-08
BRCA	SARS2	YARS	-2.58863291399932	3.63754942015711e-21
KICH	SARS2	LARS2	1.44112931619469	4.17232513427734e-06
LUAD	SARS2	CARS	-3.85793909283937	5.54313496971022e-09
PRAD	SARS2	EPRS	-1.76339127457265	9.52775218277559e-05

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with SARS2

PUF60, USP44, DMWD, ICT1, RAD21, CUL3, MTHFD1, ILF2, SPTAN1, ILF3, NENF, CALU, PRKCDBP, MATR3, TUFM, CDH2, PPT2, ESR1, FBXO17, KCMF1, UBE2A, UBE2B, HARS2, TARS, SBDS, NTRK1, NF2, CISD3, SPATA20, PPTC7, CHCHD2, NFATC1, BPNT1, EGLN3, USP15, RECQL4, MRM1, HSPD1, PDK1, TRMT61B, ATG16L1, GLUD1, APEX1, WDYHV1, PLEKHA4, ORF8b, IMMP1L, HSCB, KIF14, IFI16, PYHIN1, ACAD9, AUH, MCUR1, MTIF2, MTRF1L, TSFM, EXD2, E7, DNAJA3, OGT, TULP3, UFL1, DDRGK1, COX4I1, PDHA1, GUF1, LRWD1, NIPSNAP3A, NDUFS7, VWA8, UBR4, nsp8,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
SARS2	chr19	39405905	C	G	single_nucleotide_variant	Uncertain_significance	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis
SARS2	chr19	39405996	T	C	single_nucleotide_variant	Uncertain_significance	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
SARS2	chr19	39406013	AGCCCAGAC	A	Deletion	Likely_benign	not_provided	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
SARS2	chr19	39406022	G	A	single_nucleotide_variant	Uncertain_significance	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
SARS2	chr19	39406106	G	A	single_nucleotide_variant	Uncertain_significance	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
SARS2	chr19	39406115	G	A	single_nucleotide_variant	Uncertain_significance	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
SARS2	chr19	39406130	G	A	single_nucleotide_variant	Likely_benign	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis\|not_provided	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
SARS2	chr19	39406147	A	C	single_nucleotide_variant	Likely_benign	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
SARS2	chr19	39406167	C	G	single_nucleotide_variant	Benign	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis\|not_provided	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
SARS2	chr19	39406224	G	A	single_nucleotide_variant	Uncertain_significance	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
SARS2	chr19	39406224	G	T	single_nucleotide_variant	Uncertain_significance	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis	SO:0001624\|3_prime_UTR_variant	SO:0001624\|3_prime_UTR_variant
SARS2	chr19	39406262	T	A	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
SARS2	chr19	39406264	G	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
SARS2	chr19	39406264	G	GCCAGGCAGC	Duplication	Benign	not_specified\|not_provided	SO:0001821\|inframe_insertion	SO:0001821\|inframe_insertion
SARS2	chr19	39406302	T	C	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
SARS2	chr19	39406322	G	A	single_nucleotide_variant	Uncertain_significance	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis	SO:0001583\|missense_variant	SO:0001583\|missense_variant
SARS2	chr19	39406375	G	A	single_nucleotide_variant	Uncertain_significance	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
SARS2	chr19	39406387	G	A	single_nucleotide_variant	Likely_benign	not_specified	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
SARS2	chr19	39406428	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39406442	G	A	single_nucleotide_variant	Benign	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis\|not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39406480	C	G	single_nucleotide_variant	Likely_pathogenic	not_provided	SO:0001575\|splice_donor_variant	SO:0001575\|splice_donor_variant
SARS2	chr19	39406490	G	T	single_nucleotide_variant	Uncertain_significance	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis	SO:0001583\|missense_variant	SO:0001583\|missense_variant
SARS2	chr19	39406497	T	TC	Duplication	Uncertain_significance	not_provided	SO:0001589\|frameshift_variant	SO:0001589\|frameshift_variant
SARS2	chr19	39406508	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
SARS2	chr19	39406518	C	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
SARS2	chr19	39406526	A	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
SARS2	chr19	39406660	G	A	single_nucleotide_variant	Likely_benign	not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39406667	C	T	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis\|not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39406668	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39406677	C	T	single_nucleotide_variant	Likely_pathogenic	SARS2-associated_condition\|Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
SARS2	chr19	39406703	C	T	single_nucleotide_variant	Uncertain_significance	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis	SO:0001583\|missense_variant	SO:0001583\|missense_variant
SARS2	chr19	39406707	G	A	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
SARS2	chr19	39406709	T	A	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis\|not_specified\|not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
SARS2	chr19	39406732	C	T	single_nucleotide_variant	Uncertain_significance	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis\|not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
SARS2	chr19	39406733	G	A	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
SARS2	chr19	39406825	T	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39406867	A	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
SARS2	chr19	39406906	C	T	single_nucleotide_variant	Likely_benign	not_specified	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
SARS2	chr19	39406910	C	T	single_nucleotide_variant	Pathogenic	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis	SO:0001583\|missense_variant	SO:0001583\|missense_variant
SARS2	chr19	39406946	T	C	single_nucleotide_variant	Pathogenic	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis	SO:0001583\|missense_variant	SO:0001583\|missense_variant
SARS2	chr19	39407014	C	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39407156	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39407193	A	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39407225	A	AG	Duplication	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39408086	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39408157	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39408173	T	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39408234	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39408360	A	G	single_nucleotide_variant	Benign	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis\|not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39408377	C	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
SARS2	chr19	39408469	T	G	single_nucleotide_variant	Likely_pathogenic	SARS2-associated_condition	SO:0001583\|missense_variant	SO:0001583\|missense_variant
SARS2	chr19	39408489	C	T	single_nucleotide_variant	Likely_benign	not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39408569	A	G	single_nucleotide_variant	Pathogenic	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis	SO:0001583\|missense_variant	SO:0001583\|missense_variant
SARS2	chr19	39408606	C	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
SARS2	chr19	39408623	G	A	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
SARS2	chr19	39408658	A	G	single_nucleotide_variant	Uncertain_significance	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39408665	A	G	single_nucleotide_variant	Likely_benign	not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39408671	G	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39408688	C	G	single_nucleotide_variant	Benign	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis\|not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39408783	G	A	single_nucleotide_variant	Uncertain_significance	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39409046	CCA	C	Microsatellite	Benign/Likely_benign	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis\|not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39409078	C	T	single_nucleotide_variant	Uncertain_significance	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
SARS2	chr19	39409090	C	T	single_nucleotide_variant	Uncertain_significance	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
SARS2	chr19	39409101	C	T	single_nucleotide_variant	Uncertain_significance	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis	SO:0001583\|missense_variant	SO:0001583\|missense_variant
SARS2	chr19	39409116	G	A	single_nucleotide_variant	Uncertain_significance	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis	SO:0001583\|missense_variant	SO:0001583\|missense_variant
SARS2	chr19	39409158	T	A	single_nucleotide_variant	Uncertain_significance	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis	SO:0001583\|missense_variant	SO:0001583\|missense_variant
SARS2	chr19	39409236	C	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39409379	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39409417	C	G	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
SARS2	chr19	39409417	C	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
SARS2	chr19	39409418	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
SARS2	chr19	39409419	C	G	single_nucleotide_variant	Uncertain_significance	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis	SO:0001583\|missense_variant	SO:0001583\|missense_variant
SARS2	chr19	39409436	C	T	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
SARS2	chr19	39409458	T	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39409637	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39409720	G	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39410119	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39410398	A	G	single_nucleotide_variant	Uncertain_significance	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39410403	C	T	single_nucleotide_variant	Uncertain_significance	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis	SO:0001583\|missense_variant	SO:0001583\|missense_variant
SARS2	chr19	39410465	G	A	single_nucleotide_variant	Benign/Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
SARS2	chr19	39410467	G	A	single_nucleotide_variant	Likely_pathogenic	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis\|not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
SARS2	chr19	39410482	G	A	single_nucleotide_variant	Uncertain_significance	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis	SO:0001583\|missense_variant	SO:0001583\|missense_variant
SARS2	chr19	39410495	G	A	single_nucleotide_variant	Likely_benign	not_specified\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
SARS2	chr19	39410512	GAGAC	G	Microsatellite	Likely_benign	not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39410518	G	C	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis\|not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39410610	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39410643	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39410742	C	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
SARS2	chr19	39410743	G	A	single_nucleotide_variant	Likely_benign	not_specified	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
SARS2	chr19	39410745	G	C	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
SARS2	chr19	39410794	A	T	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis\|not_specified\|not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39410835	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39410939	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39410986	C	G	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39411889	C	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39411993	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39412023	G	A	single_nucleotide_variant	Likely_benign	not_specified\|not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39412025	G	C	single_nucleotide_variant	Likely_benign	not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39412028	C	T	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis\|not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39412031	C	T	single_nucleotide_variant	Pathogenic	not_provided	SO:0001575\|splice_donor_variant	SO:0001575\|splice_donor_variant
SARS2	chr19	39412045	G	A	single_nucleotide_variant	Benign	not_specified	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
SARS2	chr19	39412081	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
SARS2	chr19	39412083	C	T	single_nucleotide_variant	Likely_benign	not_specified	SO:0001583\|missense_variant	SO:0001583\|missense_variant
SARS2	chr19	39412091	A	G	single_nucleotide_variant	Likely_benign	not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39412101	C	G	single_nucleotide_variant	Uncertain_significance	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39412106	G	A	single_nucleotide_variant	Likely_benign	not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39412111	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39412157	C	T	single_nucleotide_variant	Uncertain_significance	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39412158	G	A	single_nucleotide_variant	Likely_benign	not_specified\|not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39412170	G	A	single_nucleotide_variant	Benign	not_specified\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
SARS2	chr19	39412200	C	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
SARS2	chr19	39412200	C	T	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis\|not_specified	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
SARS2	chr19	39412203	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
SARS2	chr19	39412253	C	T	single_nucleotide_variant	Uncertain_significance	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis	SO:0001583\|missense_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001627\|intron_variant
SARS2	chr19	39412312	G	C	single_nucleotide_variant	Uncertain_significance	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39412404	A	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39412445	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39412664	G	A	single_nucleotide_variant	Likely_benign	not_specified	SO:0001583\|missense_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001627\|intron_variant
SARS2	chr19	39412728	GT	G	Deletion	Benign/Likely_benign	not_specified\|not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39412756	A	AT	Duplication	Benign	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis\|not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39412881	C	T	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis\|not_specified\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
SARS2	chr19	39412898	C	T	single_nucleotide_variant	Uncertain_significance	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis	SO:0001583\|missense_variant	SO:0001583\|missense_variant
SARS2	chr19	39412914	G	T	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis\|not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39412921	G	A	single_nucleotide_variant	Benign	not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39413073	C	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39413120	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39413138	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39413162	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39416584	G	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39416715	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39416775	G	T	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39416855	C	T	single_nucleotide_variant	Uncertain_significance	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis	SO:0001583\|missense_variant	SO:0001583\|missense_variant
SARS2	chr19	39416856	G	A	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
SARS2	chr19	39416866	A	T	single_nucleotide_variant	Likely_benign	not_specified	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
SARS2	chr19	39416887	C	T	single_nucleotide_variant	Benign	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
SARS2	chr19	39416893	G	C	single_nucleotide_variant	Uncertain_significance	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis	SO:0001583\|missense_variant	SO:0001583\|missense_variant
SARS2	chr19	39416898	G	A	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis\|not_specified\|not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
SARS2	chr19	39416935	C	T	single_nucleotide_variant	Benign	not_specified\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
SARS2	chr19	39416966	G	T	single_nucleotide_variant	Benign	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis\|not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39416967	A	T	single_nucleotide_variant	Benign	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis\|not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39416972	G	T	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39416973	C	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39417229	C	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39420802	T	C	single_nucleotide_variant	Benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
SARS2	chr19	39421128	C	T	single_nucleotide_variant	Uncertain_significance	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
SARS2	chr19	39421129	G	A	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis\|not_specified\|not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
SARS2	chr19	39421147	C	A	single_nucleotide_variant	Uncertain_significance	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis	SO:0001583\|missense_variant	SO:0001583\|missense_variant
SARS2	chr19	39421202	C	G	single_nucleotide_variant	Uncertain_significance	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis	SO:0001583\|missense_variant	SO:0001583\|missense_variant
SARS2	chr19	39421204	A	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
SARS2	chr19	39421239	C	A	single_nucleotide_variant	Uncertain_significance	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis	SO:0001583\|missense_variant	SO:0001583\|missense_variant
SARS2	chr19	39421241	C	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
SARS2	chr19	39421274	T	C	single_nucleotide_variant	Benign	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis\|not_specified\|not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
SARS2	chr19	39421286	T	C	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis\|not_specified	SO:0001583\|missense_variant	SO:0001583\|missense_variant
SARS2	chr19	39421286	T	G	single_nucleotide_variant	Likely_benign	not_specified	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
SARS2	chr19	39421293	A	G	single_nucleotide_variant	Uncertain_significance	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
SARS2	chr19	39421333	C	G	single_nucleotide_variant	Uncertain_significance	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis	SO:0001583\|missense_variant	SO:0001583\|missense_variant
SARS2	chr19	39421347	C	T	single_nucleotide_variant	Pathogenic	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis\|not_provided	SO:0001587\|nonsense	SO:0001587\|nonsense
SARS2	chr19	39421366	G	A	single_nucleotide_variant	Uncertain_significance	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis	SO:0001583\|missense_variant	SO:0001583\|missense_variant
SARS2	chr19	39421381	G	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
SARS2	chr19	39421388	A	G	single_nucleotide_variant	Benign	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis\|not_provided	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
SARS2	chr19	39421395	C	A	single_nucleotide_variant	Uncertain_significance	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
SARS2	chr19	39421399	A	G	single_nucleotide_variant	Likely_benign	not_specified	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
SARS2	chr19	39421404	G	C	single_nucleotide_variant	Likely_benign	not_specified
SARS2	chr19	39421420	G	A	single_nucleotide_variant	Likely_benign	not_specified
SARS2	chr19	39421482	T	A	single_nucleotide_variant	Uncertain_significance	Hyperuricemia,_pulmonary_hypertension,_renal_failure,_and_alkalosis

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
SARS2	BRCA	chr19	39409429	39409429	C	T	Missense_Mutation	p.D262N	4
SARS2	BRCA	chr19	39421129	39421129	G	A	Missense_Mutation	p.S83L	4
SARS2	PAAD	chr19	39421234	39421234	G	A	Missense_Mutation	p.A48V	3
SARS2	LIHC	chr19	39421333	39421333	C	T	Missense_Mutation	p.R15H	3
SARS2	LIHC	chr19	39410461	39410461	C	-	Frame_Shift_Del	p.A234fs	3
SARS2	LIHC	chr19	39412271	39412271	C	-	Frame_Shift_Del	p.E144fs	3
SARS2	UCEC	chr19	39421225	39421225	C	T	Missense_Mutation	p.G51D	3
SARS2	DLBC	chr19	39416935	39416935	C	T	Silent	p.S91S	2
SARS2	UCEC	chr19	39410738	39410738	A	T	Missense_Mutation	p.I214N	2
SARS2	ESCA	chr19	39408448	39408448	G	T	Missense_Mutation	p.P361H	2
SARS2	UCEC	chr19	39412714	39412714	C	T	Missense_Mutation	p.R133Q	2
SARS2	LUAD	chr19	39408393	39408393	C	A	Missense_Mutation	p.E377D	2
SARS2	UCEC	chr19	39412715	39412715	G	A	Missense_Mutation	p.R133W	2
SARS2	UCEC	chr19	39421175	39421175	C	T	Missense_Mutation	p.E68K	2
SARS2	THYM	chr19	39409099	39409099	A	T	Missense_Mutation	p.D295E	2
SARS2	LIHC	chr19	39409128	39409128	A	-	Frame_Shift_Del	p.Y284fs	2
SARS2	KIRP	chr19	39412717	39412717	A	T	Splice_Site	p.V132_splice	2
SARS2	STAD	chr19	39412274	39412274	G	A	Missense_Mutation	p.R143W	2
SARS2	LIHC	chr19	39410786	39410786	A	-	Frame_Shift_Del	p.F198fs	2
SARS2	BLCA	chr19	39421110	39421110	G	A	Splice_Site	p.I89I	2
SARS2	STAD	chr19	39412279	39412279	C	T	Missense_Mutation	p.R141H	2
SARS2	UCEC	chr19	39406318	39406318	G	A	Silent	p.H495	2
SARS2	UCEC	chr19	39406322	39406322	G	A	Missense_Mutation	p.T494I	2
SARS2	HNSC	chr19	39437135	39437135	C	G	Missense_Mutation	p.Q13H	1
SARS2	OV	chr19	44113066	44113066	C	A	Missense_Mutation		1
SARS2	SKCM	chr19	39421142	39421142	C	T	Missense_Mutation	p.G79R	1
SARS2	BLCA	chr19	39421292	39421292	T	C	Missense_Mutation	p.S29G	1
SARS2	LIHC	chr19	39421215	39421215	T	C	Silent	p.A54A	1
SARS2	STAD	chr19	39406730	39406730	G	A	Missense_Mutation	p.R432C	1
SARS2	LIHC	chr19	39409134	39409134	G	-	Frame_Shift_Del	p.Q282fs	1
SARS2	KICH	chr19	39440795	39440795	C	-	Frame_Shift_Del	p.G64fs	1
SARS2	SKCM	chr19	39412175	39412175	G	A	Missense_Mutation	p.P176S	1
SARS2	LIHC	chr19	39408640	39408640	C	A	Missense_Mutation	p.C326F	1
SARS2	STAD	chr19	39406305	39406305	A	G	Missense_Mutation	p.Y500H	1
SARS2	LUAD	chr19	39421207	39421207	T	G	Missense_Mutation	p.Q57P	1
SARS2	KIRC	chr19	39421191	39421191	C	-	Frame_Shift_Del	p.F63fs	1
SARS2	SKCM	chr19	39412175	39412175	G	A	Missense_Mutation	p.P178S	1
SARS2	SKCM	chr19	39406919	39406919	G	A	Missense_Mutation	p.P399L	1
SARS2	STAD	chr19	39412061	39412061	C	T	Missense_Mutation	p.R187Q	1
SARS2	ESCA	chr19	39410778	39410778	G	A	Nonsense_Mutation	p.Q203X	1
SARS2	KIRC	chr19	39410790	39410791	-	TGGA	Splice_Site	.	1
SARS2	SKCM	chr19	39408363	39408363	C	T	Splice_Site	.	1
SARS2	SKCM	chr19	39408363	39408363	C	T	Splice_Site		1
SARS2	STAD	chr19	39435738	39435738	G	A	Silent	p.G23G	1
SARS2	CESC	chr19	39408622	39408622	C	T	Missense_Mutation	p.R330Q	1
SARS2	LIHC	chr19	39416927	39416927	T	G	Missense_Mutation	p.Q94P	1
SARS2	ESCA	chr19	39410772	39410772	G	A	Missense_Mutation	p.R205W	1
SARS2	LUAD	chr19	39408419	39408419	C	G	Missense_Mutation	p.E369Q	1
SARS2	KIRC	chr19	39408746	39408753	TCCCTGAA	-	Frame_Shift_Del	p.317_319del	1
SARS2	SKCM	chr19	39406325	39406325	G	A	Missense_Mutation	p.P495L	1
SARS2	STAD	chr19	39412061	39412061	C	T	Missense_Mutation	p.R189Q	1
SARS2	STAD	chr19	39412044	39412044	C	T	Missense_Mutation	p.G193R	1
SARS2	CESC	chr19	39408399	39408399	C	G	Missense_Mutation	p.Q377H	1
SARS2	LIHC	chr19	39408640	39408640	C	A	Missense_Mutation	p.C324F	1
SARS2	ESCA	chr19	39410747	39410747	T	C	Missense_Mutation	p.K213R	1
SARS2	LUAD	chr19	39421116	39421116	G	A	Silent	p.P87P	1
SARS2	KIRP	chr19	39409424	39409424	A	G	Silent	p.L265L	1
SARS2	SKCM	chr19	39409071	39409071	C	T	Missense_Mutation	p.G303R	1
SARS2	STAD	chr19	39406305	39406305	A	G	Missense_Mutation	p.Y502H	1
SARS2	CESC	chr19	39408622	39408622	C	T	Missense_Mutation	p.R332Q	1
SARS2	ESCA	chr19	39410764	39410764	G	A	Silent	p.H207H	1
SARS2	LUAD	chr19	39433327	39433327	C	G	Missense_Mutation	p.R88T	1
SARS2	THYM	chr19	39409099	39409099	A	T	Missense_Mutation	p.D293E	1
SARS2	CESC	chr19	39416865	39416865	C	T	Missense_Mutation	p.E115K	1
SARS2	ESCA	chr19	39406737	39406737	C	A	Missense_Mutation	p.Q431H	1
SARS2	LUSC	chr19	39439283	39439283	T	C	Missense_Mutation	p.N138D	1
SARS2	SKCM	chr19	39421248	39421248	G	A	Silent	p.L43L	1
SARS2	LGG	chr19	39421358	39421358	G	A	Missense_Mutation	p.R7W	1
SARS2	STAD	chr19	39406730	39406730	G	A	Missense_Mutation	p.R434C	1
SARS2	UCEC	chr19	39433382	39433382	C	T	Missense_Mutation	p.V70I	1
SARS2	COAD	chr19	39406677	39406677	C	A	Silent	p.T451T	1
SARS2	GBM	chr19	39408375	39408375	G	A	Silent	p.G385G	1
SARS2	LUSC	chr19	39412889	39412889	C	A	Nonsense_Mutation	p.E128*	1
SARS2	SKCM	chr19	39409116	39409116	G	A	Missense_Mutation	p.P288S	1
SARS2	LGG	chr19	39406518	39406518	C	T	Missense_Mutation	p.R459H	1
SARS2	COAD	chr19	39408571	39408571	T	C	Missense_Mutation	p.H349R	1
SARS2	GBM	chr19	39408365	39408365	G	-	Frame_Shift_Del	p.R389_splice	1
SARS2	LUSC	chr19	39409109	39409109	C	T	Missense_Mutation	p.R292H	1
SARS2	SKCM	chr19	39406325	39406325	G	A	Missense_Mutation	p.P493L	1
SARS2	BLCA	chr19	39421124	39421124	C	T	Missense_Mutation	p.D85N	1
SARS2	LGG	chr19	39421200	39421200	G	A	Silent	p.D59D	1
SARS2	STAD	chr19	39410406	39410406	C	T	Missense_Mutation	p.R254H	1
SARS2	COAD	chr19	39412677	39412677	C	T	Silent	p.T145T	1
SARS2	LIHC	chr19	39408588	39408588	C	-	Frame_Shift_Del	p.G341fs	1
SARS2	HNSC	chr19	39439299	39439299	C	A	Translation_Start_Site		1
SARS2	LUSC	chr19	39421117	39421117	G	A	Missense_Mutation	p.P87L	1
SARS2	SKCM	chr19	39421288	39421288	G	A	Missense_Mutation	p.P30L	1
SARS2	BLCA	chr19	39435635	39435635	G	T	Missense_Mutation	p.Q58K	1
SARS2	LIHC	chr19	39412662	39412662	T	A	Silent	p.P150P	1
SARS2	STAD	chr19	39410406	39410406	C	T	Missense_Mutation	p.R252H	1
SARS2	DLBC	chr19	39410465	39410465	G	A	Silent	p.R234R	1
SARS2	LIHC	chr19	39406935	39406935	G	-	Frame_Shift_Del	p.Q394fs	1

Copy number variation (CNV) of SARS2
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across SARS2
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
79208	N/A	AA630836	SARS2	chr19	39405908	-	SARS2	chr19	39406083	+
103019	OV	TCGA-5X-AA5U	SARS2	chr19	39416844	-	SIPA1L3	chr19	38519728	+
103019	OV	TCGA-5X-AA5U	SARS2	chr19	39421109	-	SIPA1L3	chr19	38519728	+
103019	OV	TCGA-5X-AA5U-01A	SARS2	chr19	39416845	-	SIPA1L3	chr19	38519729	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
TGCT	SARS2	0.000510924404216266	0.014
KIRP	SARS2	0.00100230241560951	0.027
LUAD	SARS2	0.00880682908870534	0.23
THYM	SARS2	0.0092522943886702	0.23
LUSC	SARS2	0.0145023560899237	0.35
DLBC	SARS2	0.0313156747683652	0.72
HNSC	SARS2	0.0381765249502705	0.84
PCPG	SARS2	0.0382259323576264	0.84

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
TGCT	SARS2	0.00933431650281924	0.29
LUAD	SARS2	0.0367286498144706	1
BRCA	SARS2	0.000237120675607757	0.0078
PAAD	SARS2	0.0422206979981191	1
UCEC	SARS2	0.00665673780590327	0.21
CHOL	SARS2	0.0305784444819624	0.92

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C3151209	Hyperuricemia, pulmonary hypertension, renal failure, alkalosis syndrome	3	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT