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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: SRBD1 (NCBI Gene ID:55133)

Gene Summary

Gene Summary

Gene Information	Gene Name: SRBD1
	Gene ID: 55133
	Gene Symbol	SRBD1
	Gene ID	55133
	Gene Name	S1 RNA binding domain 1
	Synonyms	-
	Cytomap	2p21
	Type of Gene	protein-coding
	Description	S1 RNA-binding domain-containing protein 1H_NH0576F01.1WUGSC:H_NH0576F01.1
	Modification date	20200313
	UniProtAcc	Q8N5C6

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
SRBD1	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'SRBD1[title] AND translation [title] AND human.'

Gene	Title	PMID
SRBD1	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000263736	45620083	45620268	Frame-shift
ENST00000263736	45704131	45704214	Frame-shift
ENST00000263736	45715378	45715470	Frame-shift
ENST00000263736	45774660	45774751	Frame-shift
ENST00000263736	45778263	45778421	Frame-shift
ENST00000263736	45780761	45780869	In-frame
ENST00000263736	45789791	45789895	Frame-shift
ENST00000263736	45812746	45812913	Frame-shift
ENST00000263736	45829041	45829222	Frame-shift

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000263736	45780761	45780869	3698	1473	1580	995	470	505

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
Q8N5C6	470	505	1	995	Chain	ID=PRO_0000284357;Note=S1 RNA-binding domain-containing protein 1

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
KICH	SRBD1	2.8976138903062	8.34465026855468e-07

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
UCEC	SRBD1	hsa-miR-4668-3p	56	0.475513791593295	0.00448023661010771

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
DLBC	SRBD1	0.039257392	0.043580125

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with SRBD1 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
DLBC	CGC	SRBD1	STRN	0.831642339	2.47E-13
DLBC	Epifactor	SRBD1	PPP4R2	0.814583763	1.87E-12
DLBC	Epifactor	SRBD1	SMARCAD1	0.824485717	5.93E-13
DLBC	TF	SRBD1	ELK3	0.8030379	6.57E-12
KICH	Cell metabolism gene	SRBD1	AGPS	0.80748684	4.12E-22
KICH	CGC	SRBD1	CUL3	0.802110531	1.24E-21
KICH	CGC	SRBD1	SF3B1	0.802974958	1.04E-21
KICH	CGC	SRBD1	GOPC	0.829653788	2.98E-24
KICH	CGC	SRBD1	FBXO11	0.832215772	1.61E-24
KICH	Epifactor	SRBD1	CUL3	0.802110531	1.24E-21
KICH	Epifactor	SRBD1	SF3B1	0.802974958	1.04E-21
KICH	Epifactor	SRBD1	ZRANB3	0.80791799	3.77E-22
KICH	Epifactor	SRBD1	HAT1	0.81150186	1.77E-22
KICH	Epifactor	SRBD1	SMEK2	0.835696781	6.88E-25
KICH	Epifactor	SRBD1	MBD5	0.870005427	4.48E-29
KICH	IUPHAR	SRBD1	PRPF4B	0.80097018	1.55E-21
KICH	IUPHAR	SRBD1	HAT1	0.81150186	1.77E-22
KICH	IUPHAR	SRBD1	FBXO11	0.832215772	1.61E-24
KICH	Kinase	SRBD1	PRPF4B	0.80097018	1.55E-21
KICH	TF	SRBD1	SP3	0.813050928	1.27E-22
KICH	TSG	SRBD1	STARD13	0.801270662	1.46E-21
KICH	TSG	SRBD1	ABI2	0.824479084	1.00E-23
KICH	TSG	SRBD1	XRCC5	0.859585681	1.09E-27
UVM	Cell metabolism gene	SRBD1	HIF1A	0.809393278	1.03E-19
UVM	Cell metabolism gene	SRBD1	AGPS	0.818707689	1.76E-20
UVM	Cell metabolism gene	SRBD1	XPO1	0.82668111	3.59E-21
UVM	Cell metabolism gene	SRBD1	SPTLC1	0.835952774	5.06E-22
UVM	CGC	SRBD1	ATM	0.800371126	5.20E-19
UVM	CGC	SRBD1	FBXO11	0.800494872	5.09E-19
UVM	CGC	SRBD1	CLTC	0.803640521	2.92E-19
UVM	CGC	SRBD1	HIF1A	0.809393278	1.03E-19
UVM	CGC	SRBD1	XPO1	0.82668111	3.59E-21
UVM	CGC	SRBD1	MSH2	0.835962769	5.05E-22
UVM	Epifactor	SRBD1	ATM	0.800371126	5.20E-19
UVM	Epifactor	SRBD1	H2AFV	0.801966357	3.93E-19
UVM	Epifactor	SRBD1	RCOR1	0.808804882	1.15E-19
UVM	Epifactor	SRBD1	SUPT16H	0.809503088	1.01E-19
UVM	Epifactor	SRBD1	ATF2	0.810043302	9.13E-20
UVM	Epifactor	SRBD1	ZRANB3	0.817957401	2.04E-20
UVM	Epifactor	SRBD1	EPC1	0.823975889	6.21E-21
UVM	IUPHAR	SRBD1	ATM	0.800371126	5.20E-19
UVM	IUPHAR	SRBD1	FBXO11	0.800494872	5.09E-19
UVM	IUPHAR	SRBD1	SLC25A40	0.81054429	8.32E-20
UVM	IUPHAR	SRBD1	MAPK8	0.816650164	2.63E-20
UVM	IUPHAR	SRBD1	XPO1	0.82668111	3.59E-21
UVM	IUPHAR	SRBD1	SPTLC1	0.835952774	5.06E-22
UVM	Kinase	SRBD1	ATM	0.800371126	5.20E-19
UVM	Kinase	SRBD1	MAPK8	0.816650164	2.63E-20
UVM	TF	SRBD1	HIF1A	0.809393278	1.03E-19
UVM	TF	SRBD1	ATF2	0.810043302	9.13E-20
UVM	TF	SRBD1	SP3	0.817257909	2.34E-20
UVM	TSG	SRBD1	ATM	0.800371126	5.20E-19
UVM	TSG	SRBD1	HIF1A	0.809393278	1.03E-19
UVM	TSG	SRBD1	MSH2	0.835962769	5.05E-22
UVM	TSG	SRBD1	WDR11	0.839017161	2.58E-22

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
STAD	SRBD1	SUPT5H	-2.30598611037995	0.000256400555372238
KICH	SRBD1	IWS1	1.79859243972269	0.000287055969238281
STAD	SRBD1	SUPT16H	-1.20575234005401	0.000557802151888609
PRAD	SRBD1	ZNF524	1.55795052608434	0.00060635853907741
KIRP	SRBD1	ZNF276	-1.83831708478486	0.00337919034063816
KICH	SRBD1	SUPT16H	-1.32435974800986	0.00460463762283325
ESCA	SRBD1	SUPT16H	-4.31197851993491	0.0048828125
KICH	SRBD1	ZNF276	-1.81765080376159	0.00507164001464844
LIHC	SRBD1	ZBTB48	-5.73884525600949	0.00667634152888414
CHOL	SRBD1	SUPT16H	-2.10481756395635	0.0078125
COAD	SRBD1	IWS1	-2.45083367488896	0.012952595949173
PRAD	SRBD1	ZNF276	-1.33324059708391	0.0130781232419534
LIHC	SRBD1	ZNF524	1.00085428513447	0.0134645669593379
LUSC	SRBD1	ZNF524	1.4758123443717	0.0230222200996548
LUSC	SRBD1	ZNF276	1.18711804697213	0.0329687445512603
COAD	SRBD1	ZNF276	-2.71750348369235	0.0334101617336274
COAD	SRBD1	ZNF827	-3.47364505883127	0.0407472252845765
STAD	SRBD1	IWS1	-2.63641783734712	1.49570405483246e-06
BRCA	SRBD1	SUPT16H	1.01187722195682	2.77480354115982e-06
KIRC	SRBD1	SUPT16H	1.69830656780067	3.74686018928209e-07
LIHC	SRBD1	SUPT5H	-1.91624502337613	4.92124311953285e-07
BRCA	SRBD1	ZNF276	1.35041713354802	5.36404101032431e-10

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with SRBD1

USP45, SART3, ELAVL1, TAOK1, CBX7, TARDBP, HECW2, rev, RPA3, RPA2, RPA1, NXF1, NTRK1, HIST1H2BG, HIST1H3A, CEP89, HNRNPU, Naa50, Lyplal1, Fbxo21, Gtf3c4, FBXW7, RCAN1, GSK3A, TRIM44, ARHGAP22, MECP2, CROCC, PPP3CC, RRP8, ZC3HC1, RPL18A, PPP3R1, ARIH1, ZBTB48, CCDC59, CDC34, MYC, RC3H1, RC3H2, HIST1H4A, SNRNP70, WWP2, PLEKHA4, FBXL17, PRKCB, SH2D3C, HSP90B1, ORF14, ESR1, CIT, CIC, IFI16, UFL1, DDRGK1, CENPA, COIL, PARP1, RPN1, ZNF330, KAL1, RPS3, PRR3, RPS16, RPL26L1, CCDC140, LARP7, RPS13, KPNA1, MYL6, ABT1, RPL23AP32, IFNLR1, APBA1, SRSF6, SCYL3, RPL27A, ZNF467, CBX6, HIST1H2AM, MAGEB2, ZNF777, H2AFB2, CCDC85A, CD6, APOBEC3C, RPL28, CROCCP2, RPL4, GAPDHS, EIF4ENIF1, MRPS35,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
SRBD1	CESC	chr2	45640374	45640374	C	A	Missense_Mutation		7
SRBD1	KIRC	chr2	45832575	45832575	T	A	Silent	p.S2S	5
SRBD1	LIHC	chr2	45826841	45826841	T	-	Frame_Shift_Del	p.K132fs	5
SRBD1	SKCM	chr2	45829063	45829063	G	A	Silent	p.V80V	4
SRBD1	UCEC	chr2	45826722	45826722	C	T	Missense_Mutation	p.D172N	4
SRBD1	SKCM	chr2	45829220	45829220	G	A	Missense_Mutation	p.S28L	4
SRBD1	KIRP	chr2	45647009	45647009	T	C	Missense_Mutation	p.K692E	4
SRBD1	KIRP	chr2	45616665	45616665	G	C	Silent	p.G924G	4
SRBD1	BRCA	chr2	45774701	45774701	G	-	Frame_Shift_Del	p.R576fs	4
SRBD1	BRCA	chr2	45774705	45774705	G	A	Silent	p.G574	4
SRBD1	BLCA	chr2	45801777	45801777	G	A	Silent	p.F386F	4
SRBD1	UCS	chr2	45812822	45812822	C	G	Missense_Mutation	p.R247P	3
SRBD1	CESC	chr2	45640334	45640334	T	C	Missense_Mutation		3
SRBD1	LIHC	chr2	45640332	45640332	T	-	Frame_Shift_Del	p.T812fs	3
SRBD1	BRCA	chr2	45704138	45704138	C	T	Missense_Mutation	p.M681I	3
SRBD1	PAAD	chr2	45645577	45645577	G	T	Missense_Mutation	p.L754M	3
SRBD1	BLCA	chr2	45616464	45616464	G	A	Silent	p.L991L	3
SRBD1	ESCA	chr2	45616543	45616543	A	G	Missense_Mutation	p.L965P	3
SRBD1	BRCA	chr2	45789854	45789854	C	T	Silent	p.T449	3
SRBD1	TGCT	chr2	45645512	45645512	C	T	Silent		3
SRBD1	CHOL	chr2	45807033	45807033	G	A	Silent		3
SRBD1	BRCA	chr2	45812872	45812872	G	A	Silent	p.A230	3
SRBD1	ACC	chr2	45801796	45801796	T	C	Missense_Mutation	p.D380G	3
SRBD1	CHOL	chr2	45807033	45807033	G	A	Silent	p.Y351Y	3
SRBD1	UCS	chr2	45620089	45620089	C	T	Missense_Mutation	p.R898Q	3
SRBD1	LIHC	chr2	45616487	45616487	G	-	Frame_Shift_Del	p.R984fs	3
SRBD1	UCEC	chr2	45789831	45789831	C	T	Missense_Mutation	p.G457E	3
SRBD1	UCS	chr2	45645642	45645642	A	C	Missense_Mutation	p.I732S	3
SRBD1	LIHC	chr2	45620171	45620171	T	-	Frame_Shift_Del	p.I871fs	3
SRBD1	UCEC	chr2	45826719	45826719	C	A	Missense_Mutation	p.D173Y	2
SRBD1	LGG	chr2	45646937	45646937	C	T	Missense_Mutation		2
SRBD1	BLCA	chr2	45789849	45789849	T	A	Missense_Mutation	p.K451M	2
SRBD1	ESCA	chr2	45616543	45616543	A	G	Missense_Mutation		2
SRBD1	STAD	chr2	45800478	45800478	G	A	Silent	p.C391C	2
SRBD1	LGG	chr2	45620175	45620175	C	T	Silent	p.E869E	2
SRBD1	LGG	chr2	45620175	45620175	C	T	Silent		2
SRBD1	SKCM	chr2	45829070	45829070	G	A	Missense_Mutation	p.S78L	2
SRBD1	LIHC	chr2	45832562	45832562	T	C	Missense_Mutation		2
SRBD1	LUAD	chr2	45829073	45829073	C	A	Missense_Mutation	p.G77V	2
SRBD1	STAD	chr2	45807020	45807020	C	T	Missense_Mutation		2
SRBD1	SARC	chr2	45780861	45780861	G	C	Missense_Mutation		2
SRBD1	STAD	chr2	45778340	45778340	A	C	Silent	p.P533P	2
SRBD1	LIHC	chr2	45645645	45645645	T	-	Frame_Shift_Del	p.N731fs	2
SRBD1	SKCM	chr2	45620195	45620195	G	A	Missense_Mutation	p.L863F	2
SRBD1	UCEC	chr2	45620220	45620220	T	G	Missense_Mutation	p.E854D	2
SRBD1	UCEC	chr2	45829068	45829068	C	A	Nonsense_Mutation	p.E79*	2
SRBD1	LUAD	chr2	45616508	45616508	C	A	Missense_Mutation	p.V977L	2
SRBD1	SARC	chr2	45780862	45780862	G	A	Missense_Mutation		2
SRBD1	CESC	chr2	45800396	45800396	G	A	Silent		2
SRBD1	LGG	chr2	45812861	45812861	C	T	Missense_Mutation	p.R234H	2
SRBD1	LIHC	chr2	45646953	45646953	A	-	Frame_Shift_Del	p.I710fs	2
SRBD1	UCEC	chr2	45645516	45645516	C	T	Missense_Mutation	p.R774Q	2
SRBD1	UCEC	chr2	45829083	45829083	T	C	Missense_Mutation	p.I74V	2
SRBD1	BRCA	chr2	45773940	45773940	C	G	Missense_Mutation	p.R602T	2
SRBD1	LUAD	chr2	45774723	45774723	G	A	Silent	p.Y568Y	2
SRBD1	PAAD	chr2	45645577	45645577	G	T	Missense_Mutation		2
SRBD1	STAD	chr2	45807020	45807020	C	T	Missense_Mutation	p.V356I	2
SRBD1	SARC	chr2	45780861	45780861	G	C	Missense_Mutation	p.P473R	2
SRBD1	CESC	chr2	45704134	45704134	G	A	Nonsense_Mutation	p.Q683*	2
SRBD1	LIHC	chr2	45808912	45808912	T	-	Frame_Shift_Del	p.I285fs	2
SRBD1	LUAD	chr2	45646961	45646961	C	G	Missense_Mutation	p.V708L	2
SRBD1	SKCM	chr2	45774702	45774702	G	A	Silent	p.F575F	2
SRBD1	UCEC	chr2	45829099	45829099	C	A	Missense_Mutation	p.K68N	2
SRBD1	COAD	chr2	45832557	45832557	C	T	Silent	p.A8A	2
SRBD1	LIHC	chr2	45812829	45812829	T	G	Missense_Mutation		2
SRBD1	LUAD	chr2	45774718	45774718	T	A	Missense_Mutation	p.H570L	2
SRBD1	STAD	chr2	45620206	45620207	-	T	Frame_Shift_Ins	p.I859fs	2
SRBD1	SARC	chr2	45780862	45780862	G	A	Missense_Mutation	p.P473S	2
SRBD1	UCEC	chr2	45715466	45715466	C	T	Missense_Mutation	p.V627I	2
SRBD1	LIHC	chr2	45812803	45812803	A	-	Frame_Shift_Del	p.I253fs	2
SRBD1	UCEC	chr2	45829168	45829168	C	A	Missense_Mutation	p.K45N	2
SRBD1	STAD	chr2	45801772	45801772	C	T	Missense_Mutation	p.R388Q	2
SRBD1	UCEC	chr2	45773945	45773945	G	A	Silent	p.A600	2
SRBD1	LGG	chr2	45778329	45778329	C	T	Missense_Mutation		2
SRBD1	LIHC	chr2	45812829	45812829	T	G	Missense_Mutation	p.I245L	2
SRBD1	STAD	chr2	45778293	45778293	C	G	Missense_Mutation	p.G549A	2
SRBD1	SKCM	chr2	45645518	45645518	G	A	Silent	p.I773I	2
SRBD1	UCEC	chr2	45778293	45778293	C	T	Missense_Mutation	p.G549D	2
SRBD1	BLCA	chr2	45826690	45826690	C	G	Missense_Mutation	p.K182N	2
SRBD1	LUAD	chr2	45778344	45778344	C	T	Missense_Mutation	p.S532N	2
SRBD1	PRAD	chr2	45773897	45773897	A	G	Silent	p.Y616Y	2
SRBD1	SKCM	chr2	45715432	45715432	C	T	Missense_Mutation	p.S638N	2
SRBD1	UCEC	chr2	45780795	45780795	C	T	Missense_Mutation	p.R495H	2
SRBD1	ESCA	chr2	45826866	45826866	G	A	Missense_Mutation	p.P124S	2
SRBD1	HNSC	chr2	45789838	45789838	A	T	Missense_Mutation	p.S455T	2
SRBD1	STAD	chr2	45812864	45812864	A	G	Missense_Mutation	p.I233T	2
SRBD1	SKCM	chr2	45801787	45801787	G	C	Missense_Mutation	p.T383R	2
SRBD1	UCEC	chr2	45807063	45807063	C	T	Silent	p.E341	2
SRBD1	LGG	chr2	45774700	45774700	C	T	Missense_Mutation		2
SRBD1	LGG	chr2	45774700	45774700	C	T	Missense_Mutation	p.R576Q	2
SRBD1	STAD	chr2	45645648	45645648	T	G	Missense_Mutation	p.K730T	2
SRBD1	SKCM	chr2	45801820	45801820	A	G	Missense_Mutation	p.I372T	2
SRBD1	UCEC	chr2	45826598	45826598	T	C	Missense_Mutation	p.D213G	2
SRBD1	BLCA	chr2	45616464	45616464	G	A	Silent		2
SRBD1	LGG	chr2	45616592	45616592	G	A	Nonsense_Mutation		2
SRBD1	ESCA	chr2	45807093	45807093	G	T	Silent		2
SRBD1	LGG	chr2	45646937	45646937	C	T	Missense_Mutation	p.V716I	2
SRBD1	STAD	chr2	45826872	45826872	C	T	Missense_Mutation	p.A122T	2
SRBD1	UCEC	chr2	45704174	45704174	T	C	Silent	p.L669L	1
SRBD1	BLCA	chr2	45826690	45826690	C	G	Missense_Mutation		1
SRBD1	COAD	chr2	45774683	45774683	T	G	Missense_Mutation	p.K582Q	1
SRBD1	LIHC	chr2	45800425	45800425	T	-	Frame_Shift_Del	p.K409fs	1
SRBD1	LIHC	chr2	45640296	45640296	C	T	Missense_Mutation		1
SRBD1	LUAD	chr2	45778281	45778281	G	A	Missense_Mutation	p.A553V	1
SRBD1	LUSC	chr2	45832512	45832512	T	A	Silent	p.S23S	1
SRBD1	SKCM	chr2	45778355	45778355	G	A	Silent	p.L528L	1
SRBD1	SARC	chr2	45773887	45773887	G	T	Missense_Mutation		1
SRBD1	LIHC	chr2	45832517	45832517	A	-	Frame_Shift_Del	p.S23fs	1
SRBD1	UCEC	chr2	45640375	45640375	G	A	Silent	p.D797D	1
SRBD1	BLCA	chr2	45801777	45801777	G	A	Silent		1
SRBD1	COAD	chr2	45774694	45774694	G	A	Missense_Mutation	p.A578V	1
SRBD1	BLCA	chr2	45808903	45808903	C	A	Nonsense_Mutation	p.E288*	1
SRBD1	GBM	chr2	45773870	45773870	C	A	Splice_Site	p.C625_splice	1
SRBD1	LUSC	chr2	45704186	45704186	T	A	Silent	p.P665P	1
SRBD1	CESC	chr2	45808930	45808930	G	A	Missense_Mutation		1
SRBD1	KIRC	chr2	45620107	45620107	G	T	Missense_Mutation	p.P892H	1
SRBD1	LGG	chr2	45616592	45616592	G	A	Nonsense_Mutation	p.R949X	1
SRBD1	LGG	chr2	45812861	45812861	C	T	Missense_Mutation		1
SRBD1	LUAD	chr2	45812906	45812906	G	C	Missense_Mutation	p.S219C	1
SRBD1	BLCA	chr2	45829094	45829094	T	C	Missense_Mutation		1
SRBD1	COAD	chr2	45801811	45801811	T	G	Missense_Mutation	p.D375A	1
SRBD1	BLCA	chr2	45620192	45620192	C	G	Missense_Mutation	p.E864Q	1
SRBD1	GBM	chr2	45801787	45801787	G	A	Missense_Mutation	p.T383M	1
SRBD1	LIHC	chr2	45645604	45645604	G	T	Silent		1
SRBD1	LUSC	chr2	45616719	45616719	G	T	Missense_Mutation	p.F906L	1
SRBD1	STAD	chr2	45826800	45826800	C	A	Nonsense_Mutation	p.E146X	1
SRBD1	STAD	chr2	45826800	45826800	C	A	Nonsense_Mutation	p.E146*	1
SRBD1	KIRP	chr2	45645662	45645662	A	C	Missense_Mutation	p.N725K	1
SRBD1	LGG	chr2	45780832	45780832	T	G	Missense_Mutation		1
SRBD1	LUAD	chr2	45620234	45620234	C	A	Missense_Mutation	p.V850F	1
SRBD1	BLCA	chr2	45789849	45789849	T	A	Missense_Mutation		1
SRBD1	COAD	chr2	45826853	45826853	C	T	Missense_Mutation	p.R128Q	1
SRBD1	GBM	chr2	45801787	45801787	G	A	Missense_Mutation		1
SRBD1	LIHC	chr2	45832517	45832517	A	-	Frame_Shift_Del		1
SRBD1	STAD	chr2	45807021	45807021	G	A	Silent	p.D355D	1
SRBD1	LGG	chr2	45807076	45807076	C	T	Missense_Mutation	p.R337K	1
SRBD1	LGG	chr2	45800362	45800362	T	G	Missense_Mutation		1
SRBD1	BLCA	chr2	45829161	45829161	G	A	Missense_Mutation		1
SRBD1	GBM	chr2	45773870	45773870	C	A	Splice_Site		1
SRBD1	STAD	chr2	45789805	45789805	A	C	Missense_Mutation	p.C466G	1
SRBD1	CESC	chr2	45704134	45704134	G	A	Nonsense_Mutation		1
SRBD1	LGG	chr2	45829117	45829117	C	T	Silent	p.K62K	1
SRBD1	LGG	chr2	45807076	45807076	C	T	Missense_Mutation		1
SRBD1	LUAD	chr2	45829187	45829187	C	A	Missense_Mutation	p.S39I	1
SRBD1	SKCM	chr2	45620130	45620130	G	A	Silent	p.V884V	1
SRBD1	BLCA	chr2	45620192	45620192	C	G	Missense_Mutation		1
SRBD1	COAD	chr2	45774701	45774701	G	A	Nonsense_Mutation	p.R576X	1
SRBD1	HNSC	chr2	45807151	45807151	G	A	Missense_Mutation		1
SRBD1	LIHC	chr2	45829136	45829136	G	T	Missense_Mutation	p.P56H	1
SRBD1	PAAD	chr2	45715393	45715393	T	G	Missense_Mutation	p.N651T	1
SRBD1	SARC	chr2	45640336	45640336	G	T	Missense_Mutation		1
SRBD1	STAD	chr2	45620207	45620208	-	T	Frame_Shift_Ins	p.I859fs	1
SRBD1	CESC	chr2	45800396	45800396	G	A	Silent	p.L419	1
SRBD1	KIRP	chr2	45800394	45800394	C	A	Silent		1
SRBD1	LGG	chr2	45616592	45616592	G	A	Nonsense_Mutation	p.R949*	1
SRBD1	LIHC	chr2	45780797	45780797	T	-	Frame_Shift_Del	p.K494fs	1
SRBD1	LUAD	chr2	45646959	45646959	C	T	Silent	p.V708V	1
SRBD1	LUAD	chr2	45616530	45616530	G	A	Silent	p.P969P	1
SRBD1	SKCM	chr2	45789855	45789855	G	C	Missense_Mutation	p.T449R	1
SRBD1	UCS	chr2	45812822	45812822	C	G	Missense_Mutation		1
SRBD1	HNSC	chr2	45789838	45789838	A	T	Missense_Mutation		1
SRBD1	PRAD	chr2	45780823	45780823	A	G	Missense_Mutation	p.Y486H	1
SRBD1	STAD	chr2	45826751	45826752	-	C	Frame_Shift_Ins	p.G162fs	1
SRBD1	CESC	chr2	45808930	45808930	G	A	Missense_Mutation	p.H279Y	1
SRBD1	LGG	chr2	45800362	45800362	T	G	Missense_Mutation	p.N430T	1
SRBD1	LIHC	chr2	45780810	45780810	T	-	Frame_Shift_Del	p.N490fs	1
SRBD1	ESCA	chr2	45807093	45807093	G	T	Silent	p.G331	1
SRBD1	LIHC	chr2	45773976	45773976	C	T	Missense_Mutation		1
SRBD1	LUAD	chr2	45778281	45778282	GC	AT	Missense_Mutation	p.A553I	1
SRBD1	SKCM	chr2	45807058	45807058	G	A	Missense_Mutation	p.P343L	1
SRBD1	UCS	chr2	45620089	45620089	C	T	Missense_Mutation		1
SRBD1	HNSC	chr2	45829214	45829214	G	A	Missense_Mutation		1
SRBD1	KIRP	chr2	45647009	45647009	T	C	Missense_Mutation		1
SRBD1	LIHC	chr2	45812867	45812867	A	G	Missense_Mutation	p.I232T	1
SRBD1	STAD	chr2	45826750	45826751	-	C	Frame_Shift_Ins	p.G162fs	1
SRBD1	LGG	chr2	45780832	45780832	T	G	Missense_Mutation	p.K483Q	1
SRBD1	LIHC	chr2	45800375	45800375	A	G	Missense_Mutation		1
SRBD1	LUAD	chr2	45800477	45800477	G	A	Nonsense_Mutation	p.Q392*	1
SRBD1	LUSC	chr2	45826850	45826850	C	A	Missense_Mutation	p.R129M	1
SRBD1	SKCM	chr2	45832545	45832545	G	A	Silent	p.V12V	1
SRBD1	UCS	chr2	45645642	45645642	A	C	Missense_Mutation		1
SRBD1	KIRP	chr2	45616665	45616665	G	C	Silent		1
SRBD1	LIHC	chr2	45616467	45616467	G	A	Silent	p.D990D	1
SRBD1	READ	chr2	45774717	45774717	A	C	Missense_Mutation	p.H570Q	1
SRBD1	THYM	chr2	45829139	45829139	G	T	Missense_Mutation	p.P55H	1
SRBD1	LIHC	chr2	45645566	45645566	T	-	Frame_Shift_Del	p.K757fs	1
SRBD1	BLCA	chr2	45829094	45829094	T	C	Missense_Mutation	p.N70S	1
SRBD1	ESCA	chr2	45826866	45826866	G	A	Missense_Mutation		1
SRBD1	LIHC	chr2	45616467	45616467	G	A	Silent		1
SRBD1	LUAD	chr2	45829179	45829179	C	T	Missense_Mutation	p.E42K	1
SRBD1	LUSC	chr2	45778336	45778336	G	A	Missense_Mutation	p.P535S	1
SRBD1	SKCM	chr2	45616639	45616639	C	A	Missense_Mutation	p.G933V	1
SRBD1	HNSC	chr2	45829214	45829214	G	A	Missense_Mutation	p.A30V	1
SRBD1	READ	chr2	45832558	45832558	G	A	Missense_Mutation	p.A8V	1
SRBD1	COAD	chr2	45616572	45616572	T	C	Silent	p.K955K	1
SRBD1	LIHC	chr2	45620207	45620207	T	-	Frame_Shift_Del	p.I859fs	1
SRBD1	BLCA	chr2	45620237	45620237	C	A	Nonsense_Mutation	p.E849*	1
SRBD1	LIHC	chr2	45800434	45800434	G	T	Missense_Mutation		1
SRBD1	LUAD	chr2	45778282	45778282	C	T	Missense_Mutation	p.A553T	1
SRBD1	LUSC	chr2	45616517	45616517	C	T	Missense_Mutation	p.E974K	1
SRBD1	SKCM	chr2	45616460	45616460	G	A	Missense_Mutation	p.R993W	1
SRBD1	CESC	chr2	45616646	45616646	G	T	Missense_Mutation		1
SRBD1	HNSC	chr2	45807146	45807146	G	C	Missense_Mutation	p.P314A	1
SRBD1	SARC	chr2	45620241	45620241	C	A	Silent		1

Copy number variation (CNV) of SRBD1
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across SRBD1
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
67610	LUAD	TCGA-44-7670	ASXL2	chr2	26101034	-	SRBD1	chr2	45715470	-
67610	LUAD	TCGA-44-7670-01A	ASXL2	chr2	26101035	-	SRBD1	chr2	45647033	-
67610	LUAD	TCGA-44-7670-01A	ASXL2	chr2	26101035	-	SRBD1	chr2	45704214	-
67610	LUAD	TCGA-44-7670-01A	ASXL2	chr2	26101035	-	SRBD1	chr2	45715470	-
67610	BRCA	TCGA-AR-A24H-01A	MCFD2	chr2	47134949	-	SRBD1	chr2	45647033	-
67610	BRCA	TCGA-AR-A24H-01A	MCFD2	chr2	47136162	-	SRBD1	chr2	45715470	-
67613	LUSC	TCGA-52-7809	PPM1B	chr2	44396413	+	SRBD1	chr2	45647033	-
86233	SKCM	TCGA-EB-A6L9-06A	SRBD1	chr2	45704132	-	ATL2	chr2	38523255	-
86233	SKCM	TCGA-EB-A6L9-06A	SRBD1	chr2	45789792	-	C2orf91	chr2	42165753	-
86233	SKCM	TCGA-EB-A6L9-06A	SRBD1	chr2	45800346	-	C2orf91	chr2	42165753	-
103101	BRCA	TCGA-A7-A26G-01A	SRBD1	chr2	45704132	-	CCDC88A	chr2	55646052	-
86233	BRCA	TCGA-BH-A209-01A	SRBD1	chr2	45780762	-	PLEKHA6	chr1	204243937	-
101218	Non-Cancer	173N	SRBD1	chr2	45645503	-	PPM1B	chr2	44459454	+
100817	N/A	AL117549	SRBD1	chr2	45789623	-	VPS37A	chr8	17161330	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRP	SRBD1	0.00255658557097804	0.072
TGCT	SRBD1	0.0088920469117841	0.24
BLCA	SRBD1	0.0110966333491126	0.29
LIHC	SRBD1	0.0161197706947011	0.4
ESCA	SRBD1	0.0289305665875143	0.69

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LGG	SRBD1	0.0310441861257825	1

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source