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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: MRPS18A (NCBI Gene ID:55168)

Gene Summary

Gene Summary

Gene Information	Gene Name: MRPS18A
	Gene ID: 55168
	Gene Symbol	MRPS18A
	Gene ID	55168
	Gene Name	mitochondrial ribosomal protein S18A
	Synonyms	HumanS18b\|MRP-S18-3\|MRP-S18-a\|MRPS18-3\|S18bmt\|S18mt-a
	Cytomap	6p21.1
	Type of Gene	protein-coding
	Description	39S ribosomal protein S18a, mitochondrial28S ribosomal protein S18-3, mitochondrial28S ribosomal protein S18a, mitochondrial39S ribosomal protein S18-3, mitochondrialmitochondrial large ribosomal subunit protein bS18amitochondrial large ribosomal sub
	Modification date	20200313
	UniProtAcc	Q9NVS2

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0032543	Mitochondrial translation
GO:0005840	Ribosome
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
MRPS18A	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'MRPS18A[title] AND translation [title] AND human.'

Gene	Title	PMID
MRPS18A	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000372133	43642938	43643008	Frame-shift
ENST00000372133	43646254	43646362	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000372133	43646254	43646362	1079	157	264	196	48	84

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
Q9NVS2	48	84	35	196	Chain	ID=PRO_0000030625;Note=39S ribosomal protein S18a%2C mitochondrial
Q9NVS2	48	84	48	53	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5OOM
Q9NVS2	48	84	73	75	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5OOM

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
LUAD	MRPS18A	-1.54123864042049	0.000452706327224566
PRAD	MRPS18A	-1.89251195553289	0.0168224419088856
LUSC	MRPS18A	-4.26181803018125	1.79996309233889e-05
HNSC	MRPS18A	-2.4520120168475	5.97184352955084e-05

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
CESC	MRPS18A	1	2	0.0248408315445073	0.169794158653846	0.218827283653846	-2.00298273357357	-2.81107542588104
DLBC	MRPS18A	1	2	0.0385744055652316	0.1734328125	0.222765	-2.61413037093593	-3.43685965665

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
HNSC	MRPS18A	1	2	0.0192138810073424	0.190547549019608	0.232508771929825	0.386836582360214	0.298827913629514
SARC	MRPS18A	1	2	0.0206189420251959	0.182898168498169	0.236924531835206	-0.0290737925589858	0.108185128295397

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
STAD	MRPS18A	0.123227749	0.038007982

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with MRPS18A (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
DLBC	Cell metabolism gene	MRPS18A	PSMB10	0.802407278	7.02E-12
DLBC	Cell metabolism gene	MRPS18A	TOMM22	0.805900506	4.85E-12
DLBC	Cell metabolism gene	MRPS18A	GEMIN7	0.80707834	4.27E-12
DLBC	Cell metabolism gene	MRPS18A	EXOSC4	0.808183314	3.79E-12
DLBC	Cell metabolism gene	MRPS18A	SNRPB	0.808448248	3.69E-12
DLBC	Cell metabolism gene	MRPS18A	DPM2	0.812933256	2.25E-12
DLBC	Cell metabolism gene	MRPS18A	PSMB4	0.815552987	1.68E-12
DLBC	Cell metabolism gene	MRPS18A	DTYMK	0.817666602	1.32E-12
DLBC	Cell metabolism gene	MRPS18A	PSMD4	0.819227161	1.10E-12
DLBC	Cell metabolism gene	MRPS18A	PSMD13	0.824072831	6.23E-13
DLBC	Cell metabolism gene	MRPS18A	PSMC1	0.824652601	5.82E-13
DLBC	Cell metabolism gene	MRPS18A	TIMM50	0.830459596	2.86E-13
DLBC	Cell metabolism gene	MRPS18A	HSD17B10	0.832137946	2.32E-13
DLBC	Cell metabolism gene	MRPS18A	PSMB7	0.833340029	2.00E-13
DLBC	Cell metabolism gene	MRPS18A	PSMA6	0.833562805	1.94E-13
DLBC	Cell metabolism gene	MRPS18A	PSMB6	0.84248744	6.05E-14
DLBC	Cell metabolism gene	MRPS18A	PSMC3	0.844132622	4.84E-14
DLBC	Cell metabolism gene	MRPS18A	TIMM13	0.850695689	1.94E-14
DLBC	Cell metabolism gene	MRPS18A	MED27	0.851762052	1.66E-14
DLBC	Cell metabolism gene	MRPS18A	PSMC5	0.852443028	1.51E-14
DLBC	Cell metabolism gene	MRPS18A	ITPA	0.852965094	1.40E-14
DLBC	Cell metabolism gene	MRPS18A	PSMB3	0.874171042	4.94E-16
DLBC	CGC	MRPS18A	NTHL1	0.800585604	8.49E-12
DLBC	CGC	MRPS18A	TFPT	0.802379282	7.04E-12
DLBC	Epifactor	MRPS18A	TFPT	0.802379282	7.04E-12
DLBC	Epifactor	MRPS18A	EXOSC4	0.808183314	3.79E-12
DLBC	Epifactor	MRPS18A	SIRT6	0.813668221	2.07E-12
DLBC	Epifactor	MRPS18A	RBX1	0.817367002	1.36E-12
DLBC	Epifactor	MRPS18A	PPP4C	0.81849896	1.20E-12
DLBC	IUPHAR	MRPS18A	MFSD2B	0.808252028	3.76E-12
DLBC	IUPHAR	MRPS18A	SIRT6	0.813668221	2.07E-12
DLBC	IUPHAR	MRPS18A	PSMB6	0.84248744	6.05E-14
DLBC	TF	MRPS18A	PIN1	0.828021184	3.87E-13
DLBC	TSG	MRPS18A	PHB	0.804454556	5.66E-12
DLBC	TSG	MRPS18A	SIRT6	0.813668221	2.07E-12
DLBC	TSG	MRPS18A	PIN1	0.828021184	3.87E-13
DLBC	TSG	MRPS18A	GADD45GIP1	0.844676799	4.49E-14
THCA	TSG	MRPS18A	PHB	0.83993282	1.97E-153
THYM	Cell metabolism gene	MRPS18A	NT5C	0.800452063	1.91E-28
THYM	Cell metabolism gene	MRPS18A	POLR2L	0.802608394	1.07E-28
THYM	Cell metabolism gene	MRPS18A	SNRPD2	0.803205767	9.08E-29
THYM	Cell metabolism gene	MRPS18A	GFER	0.805801907	4.45E-29
THYM	Cell metabolism gene	MRPS18A	PSMC3	0.815860056	2.52E-30
THYM	Cell metabolism gene	MRPS18A	IDH3B	0.818057019	1.32E-30
THYM	Cell metabolism gene	MRPS18A	OAZ1	0.820489537	6.34E-31
THYM	Cell metabolism gene	MRPS18A	POLR2E	0.820818743	5.74E-31
THYM	Cell metabolism gene	MRPS18A	TALDO1	0.82594428	1.18E-31
THYM	Cell metabolism gene	MRPS18A	PSMD9	0.828948918	4.58E-32
THYM	Cell metabolism gene	MRPS18A	TIMM13	0.844657792	2.32E-34
THYM	Cell metabolism gene	MRPS18A	LSM2	0.84655815	1.18E-34
THYM	Cell metabolism gene	MRPS18A	PSMB1	0.849646704	3.83E-35
THYM	CGC	MRPS18A	TFPT	0.807041791	3.15E-29
THYM	CGC	MRPS18A	ASPSCR1	0.807899805	2.48E-29
THYM	CGC	MRPS18A	MAP2K2	0.827650782	6.92E-32
THYM	Epifactor	MRPS18A	TFPT	0.807041791	3.15E-29
THYM	Epifactor	MRPS18A	C17orf49	0.808383292	2.16E-29
THYM	Epifactor	MRPS18A	PRPF31	0.813234894	5.43E-30
THYM	Epifactor	MRPS18A	PRMT1	0.815602842	2.72E-30
THYM	Epifactor	MRPS18A	FBL	0.838446056	2.01E-33
THYM	Epifactor	MRPS18A	MBD3	0.857812491	1.73E-36
THYM	IUPHAR	MRPS18A	NT5C	0.800452063	1.91E-28
THYM	IUPHAR	MRPS18A	EGLN2	0.804935399	5.65E-29
THYM	IUPHAR	MRPS18A	PRMT1	0.815602842	2.72E-30
THYM	IUPHAR	MRPS18A	MAP2K2	0.827650782	6.92E-32
THYM	IUPHAR	MRPS18A	PSMB1	0.849646704	3.83E-35
THYM	Kinase	MRPS18A	MAP2K2	0.827650782	6.92E-32
THYM	TF	MRPS18A	THAP3	0.809608464	1.53E-29
THYM	TF	MRPS18A	REXO4	0.817570811	1.52E-30
THYM	TF	MRPS18A	ZNF408	0.827191813	8.00E-32
THYM	TF	MRPS18A	MBD3	0.857812491	1.73E-36
THYM	TSG	MRPS18A	PHB	0.809544834	1.56E-29
THYM	TSG	MRPS18A	TSSC4	0.850746052	2.55E-35
UCS	Cell metabolism gene	MRPS18A	NT5C	0.800452063	1.91E-28
UCS	Cell metabolism gene	MRPS18A	POLR2L	0.802608394	1.07E-28
UCS	Cell metabolism gene	MRPS18A	SNRPD2	0.803205767	9.08E-29
UCS	Cell metabolism gene	MRPS18A	GFER	0.805801907	4.45E-29
UCS	Cell metabolism gene	MRPS18A	PSMC3	0.815860056	2.52E-30
UCS	Cell metabolism gene	MRPS18A	IDH3B	0.818057019	1.32E-30
UCS	Cell metabolism gene	MRPS18A	OAZ1	0.820489537	6.34E-31
UCS	Cell metabolism gene	MRPS18A	POLR2E	0.820818743	5.74E-31
UCS	Cell metabolism gene	MRPS18A	TALDO1	0.82594428	1.18E-31
UCS	Cell metabolism gene	MRPS18A	PSMD9	0.828948918	4.58E-32
UCS	Cell metabolism gene	MRPS18A	TIMM13	0.844657792	2.32E-34
UCS	Cell metabolism gene	MRPS18A	LSM2	0.84655815	1.18E-34
UCS	Cell metabolism gene	MRPS18A	PSMB1	0.849646704	3.83E-35
UCS	CGC	MRPS18A	TFPT	0.807041791	3.15E-29
UCS	CGC	MRPS18A	ASPSCR1	0.807899805	2.48E-29
UCS	CGC	MRPS18A	MAP2K2	0.827650782	6.92E-32
UCS	Epifactor	MRPS18A	TFPT	0.807041791	3.15E-29
UCS	Epifactor	MRPS18A	C17orf49	0.808383292	2.16E-29
UCS	Epifactor	MRPS18A	PRPF31	0.813234894	5.43E-30
UCS	Epifactor	MRPS18A	PRMT1	0.815602842	2.72E-30
UCS	Epifactor	MRPS18A	FBL	0.838446056	2.01E-33
UCS	Epifactor	MRPS18A	MBD3	0.857812491	1.73E-36
UCS	IUPHAR	MRPS18A	NT5C	0.800452063	1.91E-28
UCS	IUPHAR	MRPS18A	EGLN2	0.804935399	5.65E-29
UCS	IUPHAR	MRPS18A	PRMT1	0.815602842	2.72E-30
UCS	IUPHAR	MRPS18A	MAP2K2	0.827650782	6.92E-32
UCS	IUPHAR	MRPS18A	PSMB1	0.849646704	3.83E-35
UCS	Kinase	MRPS18A	MAP2K2	0.827650782	6.92E-32
UCS	TF	MRPS18A	THAP3	0.809608464	1.53E-29
UCS	TF	MRPS18A	REXO4	0.817570811	1.52E-30
UCS	TF	MRPS18A	ZNF408	0.827191813	8.00E-32
UCS	TF	MRPS18A	MBD3	0.857812491	1.73E-36
UCS	TSG	MRPS18A	PHB	0.809544834	1.56E-29
UCS	TSG	MRPS18A	TSSC4	0.850746052	2.55E-35
UVM	Cell metabolism gene	MRPS18A	PPP2R5D	0.845949362	5.33E-23
UVM	CGC	MRPS18A	HMGA1	0.808874563	1.13E-19
UVM	Epifactor	MRPS18A	RNF40	0.813011679	5.25E-20
UVM	IUPHAR	MRPS18A	CSNK2B	0.832256174	1.12E-21
UVM	TF	MRPS18A	HMGA1	0.808874563	1.13E-19

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
COAD	MRPS18A	MRPS12	2.11566333114824	0.000125885009765625
BRCA	MRPS18A	MRPS15	-2.19567551682318	0.000188684660674703
KICH	MRPS18A	MRPS5	1.25108287838437	0.000249803066253662
LIHC	MRPS18A	MRPS7	1.27029395477208	0.00182077236082954
KIRC	MRPS18A	MRPS18B	-1.08999348010674	0.00208385211535325
STAD	MRPS18A	MRPS16	-1.64208084987431	0.00239070039242506
LIHC	MRPS18A	MRPS18C	-1.25336042046698	0.00251545393492315
COAD	MRPS18A	MRPS18C	-3.48505830240365	0.00322914123535157
KIRC	MRPS18A	MRPS15	1.11572283836012	0.00361818577801855
ESCA	MRPS18A	MRPS12	-1.86248549814506	0.0048828125
HNSC	MRPS18A	MRPS16	-2.01564621821803	0.00518989327406416
CHOL	MRPS18A	MRPS18B	-1.34341961473083	0.0078125
THCA	MRPS18A	MRPS15	-1.19960602422995	0.0140154883942907
BLCA	MRPS18A	MRPS18B	-2.79316203705083	0.0180816650390625
ESCA	MRPS18A	MRPS5	-2.15440118747854	0.0185546875
LUAD	MRPS18A	MRPS18B	-2.59132604284176	0.0228310323601027
HNSC	MRPS18A	MRPS12	1.33677139927136	0.0248336488591576
STAD	MRPS18A	MRPS18B	-2.18783845061495	0.0341199110262096
LUAD	MRPS18A	MRPS12	-5.3399185683719	1.00823612619819e-08
THCA	MRPS18A	MRPS10	1.33413691764991	1.55171507174296e-05
BRCA	MRPS18A	MRPS12	-1.59537235222597	1.66215672512325e-20
LUAD	MRPS18A	MRPS5	-2.20881945885927	1.77904381378076e-06
LUAD	MRPS18A	MRPL42	-6.34610249602491	2.48255276366547e-08
LIHC	MRPS18A	MRPS12	2.67189430810317	2.56696988045444e-05
KICH	MRPS18A	MRPS12	1.48941080926405	3.19480895996094e-05
LUAD	MRPS18A	MRPS14	-3.02634914022647	4.24616078981701e-06
LUSC	MRPS18A	MRPS5	-7.65956389962319	4.27210217182982e-06
KIRC	MRPS18A	MRPL42	-4.382095336248	5.26630854166927e-06
LUSC	MRPS18A	MRPS14	-3.86726163364221	6.1453992201761e-05
BRCA	MRPS18A	MRPS7	-2.12787460270434	9.33194208595055e-10

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with MRPS18A

ICT1, APP, BTRC, FBXW11, NOL12, RPL13, ZNF22, RBMS3, MRPL28, RPL6, MRPL39, MRPL47, HNRNPA1, MRPS30, MRPL4, ZNF317, NIPSNAP1, MRPL50, MRPL9, MRPL1, FOXL2, MRPL10, MRPL42, MRPL41, MRPL35, CYLD, TRIM25, vIRF-4, CTNNBL1, LEO1, MRPS5, WDR61, PCBP1, LARP7, MRM1, PDK1, TRMT61B, AURKAIP1, SNRNP70, NFX1, PLEKHA4, PRKCI, SH3GL3, AUH, C12orf65, C1QBP, C21orf33, C6orf203, CS, DDX28, FASTKD5, GFM1, LRPPRC, MDH2, METTL15, METTL17, MRPL11, MRPS12, MTERF3, MTIF2, MTIF3, MTRF1, MTRF1L, NGRN, PMPCA, PMPCB, RPUSD4, SSBP1, TACO1, TBRG4, TMEM70, TRUB2, TSFM, TUFM, MRPL18, MRPL19, MRPL21, MRPL27, MRPL17, MRPL49, MRPL15, MRPL38, MRPL44, MRPL45, HIST1H1T, MRPL30, FZR1, RPL27A, YBX1, MRPL13, MALSU1, MRPL33, RPL37, SRSF3, RBMS2, MRPL23, YBX2, MRPL2, H1FNT, MRPL53, RBM47, RPL3, MRPL46, FAHD1, MRPL24, RPL13A, SRSF7, GADD45GIP1, ZNF346, MRPL20, PRR3, MRPL51, RPL23A, MRPL55, LRRC1, MRPL52, LIN28A, APOBEC3D, MRPL57, MRPL37, RPL35, NEIL1, YARS2, MRPL16, MRPL12, PTCD1, FASTKD2, ABT1, MRPL32, RPL10, RPS8, MRPL40, RPL17, KLF15,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
MRPS18A	SKCM	chr6	43643271	43643271	G	A	Silent	p.H112H	2
MRPS18A	COAD	chr6	43642963	43642963	G	A	Missense_Mutation	p.P141L	2
MRPS18A	KIRP	chr6	43655468	43655468	C	A	Missense_Mutation		2
MRPS18A	SKCM	chr6	43639608	43639608	G	A	Missense_Mutation	p.P161L	2
MRPS18A	LIHC	chr6	43639588	43639588	G	-	Frame_Shift_Del	p.R168fs	2
MRPS18A	ESCA	chr6	43655404	43655404	C	G	Splice_Site	.	2
MRPS18A	ESCA	chr6	43642962	43642962	C	A	Silent	p.P141P	2
MRPS18A	LUAD	chr6	43648835	43648835	C	T	Silent	p.K45K	2
MRPS18A	UCEC	chr6	43643270	43643270	G	A	Missense_Mutation	p.R113C	2
MRPS18A	KIRC	chr6	43642986	43642986	A	T	Silent	p.P133P	2
MRPS18A	SARC	chr6	43646316	43646316	G	T	Missense_Mutation		1
MRPS18A	BLCA	chr6	43642976	43642976	C	T	Missense_Mutation	p.E137K	1
MRPS18A	KIRP	chr6	43646267	43646267	C	T	Silent	p.K80K	1
MRPS18A	COAD	chr6	43646286	43646286	C	T	Missense_Mutation	p.R74H	1
MRPS18A	LGG	chr6	43639572	43639572	C	T	Missense_Mutation	p.R173H	1
MRPS18A	SKCM	chr6	43639616	43639616	G	A	Silent	p.S158S	1
MRPS18A	ESCA	chr6	43642962	43642962	C	A	Silent	p.P141	1
MRPS18A	LIHC	chr6	43639595	43639595	T	-	Frame_Shift_Del		1
MRPS18A	SKCM	chr6	43639617	43639617	G	A	Missense_Mutation	p.S158F	1
MRPS18A	ESCA	chr6	43655404	43655404	C	G	Splice_Site	e1+1	1
MRPS18A	THYM	chr6	43642941	43642941	G	T	Missense_Mutation		1
MRPS18A	LIHC	chr6	43642949	43642949	G	-	Frame_Shift_Del	p.Q146fs	1
MRPS18A	THYM	chr6	43655412	43655412	G	T	Missense_Mutation	p.F35L	1
MRPS18A	LIHC	chr6	43639595	43639595	T	-	Frame_Shift_Del	p.K165fs	1
MRPS18A	THYM	chr6	43642941	43642941	G	T	Missense_Mutation	p.N148K	1
MRPS18A	HNSC	chr6	43643089	43643089	G	A	Missense_Mutation		1
MRPS18A	BLCA	chr6	43643158	43643158	G	A	Missense_Mutation		1
MRPS18A	HNSC	chr6	43643156	43643156	C	A	Missense_Mutation		1
MRPS18A	LUAD	chr6	43646287	43646287	G	A	Missense_Mutation	p.R74C	1
MRPS18A	BLCA	chr6	43642976	43642976	C	T	Missense_Mutation		1
MRPS18A	HNSC	chr6	43639527	43639527	G	C	Nonsense_Mutation	p.S188*	1
MRPS18A	SARC	chr6	43646325	43646325	G	T	Missense_Mutation		1
MRPS18A	BLCA	chr6	43655472	43655472	G	A	Silent	p.L15L	1

Copy number variation (CNV) of MRPS18A
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across MRPS18A
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
73885	UCEC	TCGA-AJ-A3BF-01A	MRPS18A	chr6	43655405	-	CDIP1	chr16	4564665	-
100035	STAD	TCGA-BR-A4PE-01A	MRPS18A	chr6	43655405	-	FAM120A	chr9	96305504	+
101861	KIRC	TCGA-A3-3313-01A	MRPS18A	chr6	43648826	-	KIF6	chr6	39353448	-
80727	SARC	TCGA-HB-A3YV-01A	MRPS18A	chr6	43648826	-	METTL7A	chr12	51318450	+
98036	CESC	TCGA-HG-A2PA-01A	MRPS18A	chr6	43639577	-	RSPH9	chr6	43623299	+
93662	SARC	TCGA-DX-A23Y-01A	MRPS18A	chr6	43639577	-	TRAF3IP2	chr6	111894186	-
103250	ESCA	TCGA-L5-A4OJ	POLR1C	chr6	43488786	+	MRPS18A	chr6	43639643	-
103250	STAD	TCGA-BR-8372-01A	TJAP1	chr6	43471444	+	MRPS18A	chr6	43643354	-
103250	KIRC	TCGA-A3-3313-01A	ZSCAN9	chr6	28195615	+	MRPS18A	chr6	43643354	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
PAAD	MRPS18A	0.00648904351713351	0.18
MESO	MRPS18A	0.0108554618182555	0.29
KIRC	MRPS18A	0.0208350470409104	0.54
KIRP	MRPS18A	0.0267316371982566	0.67
SKCM	MRPS18A	0.0359800473845635	0.86

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
STAD	MRPS18A	0.0402492631413883	1
LUSC	MRPS18A	0.029752867316874	0.92
THCA	MRPS18A	0.0473708017825358	1
LGG	MRPS18A	0.0112736348137865	0.36
PAAD	MRPS18A	0.00192976102486412	0.064

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source