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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: EIF2AK2 (NCBI Gene ID:5610)

Gene Summary

Gene Summary

Gene Information	Gene Name: EIF2AK2
	Gene ID: 5610
	Gene Symbol	EIF2AK2
	Gene ID	5610
	Gene Name	eukaryotic translation initiation factor 2 alpha kinase 2
	Synonyms	EIF2AK1\|PKR\|PPP1R83\|PRKR
	Cytomap	2p22.2
	Type of Gene	protein-coding
	Description	interferon-induced, double-stranded RNA-activated protein kinaseP1/eIF-2A protein kinasedouble stranded RNA activated protein kinaseeIF-2A protein kinase 2interferon-inducible elF2alpha kinasep68 kinaseprotein kinase Rprotein kinase, interferon-ind
	Modification date	20200313
	UniProtAcc	P19525

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0017148	Negative regulation of translation
GO:0006417	Regulation of translation
GO:0005840	Ribosome
GO:0006413	Translational initiation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	EIF2AK2	GO:0006468	protein phosphorylation	19189853
Hgene	EIF2AK2	GO:0017148	negative regulation of translation	12882984
Hgene	EIF2AK2	GO:0035455	response to interferon-alpha	19840259
Hgene	EIF2AK2	GO:0046777	protein autophosphorylation	22801494
Hgene	EIF2AK2	GO:0051092	positive regulation of NF-kappaB transcription factor activity	15121867

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
EIF2AK2	(733 - 1119.25]

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Translation Studies in PubMed

We searched PubMed using 'EIF2AK2[title] AND translation [title] AND human.'

Gene	Title	PMID
EIF2AK2	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000233057	37334616	37334670	In-frame
ENST00000395127	37334616	37334670	In-frame
ENST00000233057	37341873	37342002	In-frame
ENST00000395127	37341873	37342002	In-frame
ENST00000233057	37349648	37349807	In-frame
ENST00000395127	37349648	37349807	In-frame
ENST00000233057	37353431	37353554	In-frame
ENST00000395127	37353431	37353554	In-frame
ENST00000233057	37362626	37362689	In-frame
ENST00000395127	37362626	37362689	In-frame
ENST00000233057	37365651	37365728	Frame-shift
ENST00000395127	37365651	37365728	Frame-shift
ENST00000395127	37375999	37376400	3UTR-3UTR

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000395127	37334616	37334670	2947	2037	2090	551	493	511
ENST00000233057	37334616	37334670	10059	1803	1856	551	493	511
ENST00000395127	37341873	37342002	2947	1806	1934	551	416	459
ENST00000233057	37341873	37342002	10059	1572	1700	551	416	459
ENST00000395127	37349648	37349807	2947	1466	1624	551	303	355
ENST00000233057	37349648	37349807	10059	1232	1390	551	303	355
ENST00000395127	37353431	37353554	2947	1343	1465	551	262	302
ENST00000233057	37353431	37353554	10059	1109	1231	551	262	302
ENST00000395127	37362626	37362689	2947	1280	1342	551	241	261
ENST00000233057	37362626	37362689	10059	1046	1108	551	241	261

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
P19525	241	261	2	551	Chain	ID=PRO_0000085945;Note=Interferon-induced%2C double-stranded RNA-activated protein kinase
P19525	262	302	2	551	Chain	ID=PRO_0000085945;Note=Interferon-induced%2C double-stranded RNA-activated protein kinase
P19525	416	459	2	551	Chain	ID=PRO_0000085945;Note=Interferon-induced%2C double-stranded RNA-activated protein kinase
P19525	493	511	2	551	Chain	ID=PRO_0000085945;Note=Interferon-induced%2C double-stranded RNA-activated protein kinase
P19525	303	355	2	551	Chain	ID=PRO_0000085945;Note=Interferon-induced%2C double-stranded RNA-activated protein kinase
P19525	241	261	2	551	Chain	ID=PRO_0000085945;Note=Interferon-induced%2C double-stranded RNA-activated protein kinase
P19525	262	302	2	551	Chain	ID=PRO_0000085945;Note=Interferon-induced%2C double-stranded RNA-activated protein kinase
P19525	416	459	2	551	Chain	ID=PRO_0000085945;Note=Interferon-induced%2C double-stranded RNA-activated protein kinase
P19525	493	511	2	551	Chain	ID=PRO_0000085945;Note=Interferon-induced%2C double-stranded RNA-activated protein kinase
P19525	303	355	2	551	Chain	ID=PRO_0000085945;Note=Interferon-induced%2C double-stranded RNA-activated protein kinase
P19525	262	302	267	538	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P19525	416	459	267	538	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P19525	493	511	267	538	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P19525	303	355	267	538	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P19525	262	302	267	538	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P19525	416	459	267	538	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P19525	493	511	267	538	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P19525	303	355	267	538	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P19525	303	355	331	343	Repeat	Note=1
P19525	303	355	331	343	Repeat	Note=1
P19525	303	355	345	357	Repeat	Note=2
P19525	303	355	345	357	Repeat	Note=2
P19525	262	302	273	281	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P19525	262	302	273	281	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
P19525	262	302	266	551	Region	Note=Interaction with TRAF5;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:15121867;Dbxref=PMID:15121867
P19525	416	459	266	551	Region	Note=Interaction with TRAF5;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:15121867;Dbxref=PMID:15121867
P19525	493	511	266	551	Region	Note=Interaction with TRAF5;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:15121867;Dbxref=PMID:15121867
P19525	303	355	266	551	Region	Note=Interaction with TRAF5;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:15121867;Dbxref=PMID:15121867
P19525	262	302	266	551	Region	Note=Interaction with TRAF5;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:15121867;Dbxref=PMID:15121867
P19525	416	459	266	551	Region	Note=Interaction with TRAF5;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:15121867;Dbxref=PMID:15121867
P19525	493	511	266	551	Region	Note=Interaction with TRAF5;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:15121867;Dbxref=PMID:15121867
P19525	303	355	266	551	Region	Note=Interaction with TRAF5;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:15121867;Dbxref=PMID:15121867
P19525	303	355	331	357	Region	Note=2 X 13 AA approximate repeats
P19525	303	355	331	357	Region	Note=2 X 13 AA approximate repeats
P19525	262	302	296	296	Binding site	Note=ATP
P19525	262	302	296	296	Binding site	Note=ATP
P19525	241	261	242	242	Modified residue	Note=Phosphoserine%3B by autocatalysis;Ontology_term=ECO:0000305;evidence=ECO:0000305\|PubMed:11152499;Dbxref=PMID:11152499
P19525	241	261	242	242	Modified residue	Note=Phosphoserine%3B by autocatalysis;Ontology_term=ECO:0000305;evidence=ECO:0000305\|PubMed:11152499;Dbxref=PMID:11152499
P19525	241	261	255	255	Modified residue	Note=Phosphothreonine%3B by autocatalysis;Ontology_term=ECO:0000305;evidence=ECO:0000305\|PubMed:11152499;Dbxref=PMID:11152499
P19525	241	261	255	255	Modified residue	Note=Phosphothreonine%3B by autocatalysis;Ontology_term=ECO:0000305;evidence=ECO:0000305\|PubMed:11152499;Dbxref=PMID:11152499
P19525	241	261	258	258	Modified residue	Note=Phosphothreonine%3B by autocatalysis;Ontology_term=ECO:0000305;evidence=ECO:0000305\|PubMed:11152499;Dbxref=PMID:11152499
P19525	241	261	258	258	Modified residue	Note=Phosphothreonine%3B by autocatalysis;Ontology_term=ECO:0000305;evidence=ECO:0000305\|PubMed:11152499;Dbxref=PMID:11152499
P19525	262	302	293	293	Modified residue	Note=Phosphotyrosine%3B by autocatalysis;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16373505;Dbxref=PMID:16373505
P19525	262	302	293	293	Modified residue	Note=Phosphotyrosine%3B by autocatalysis;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16373505;Dbxref=PMID:16373505
P19525	416	459	446	446	Modified residue	Note=Phosphothreonine%3B by autocatalysis;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11337501,ECO:0000269\|PubMed:16179258;Dbxref=PMID:11337501,PMID:16179258
P19525	416	459	446	446	Modified residue	Note=Phosphothreonine%3B by autocatalysis;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11337501,ECO:0000269\|PubMed:16179258;Dbxref=PMID:11337501,PMID:16179258
P19525	416	459	451	451	Modified residue	Note=Phosphothreonine%3B by autocatalysis;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11337501,ECO:0000269\|PubMed:20685959;Dbxref=PMID:11337501,PMID:20685959
P19525	416	459	451	451	Modified residue	Note=Phosphothreonine%3B by autocatalysis;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11337501,ECO:0000269\|PubMed:20685959;Dbxref=PMID:11337501,PMID:20685959
P19525	416	459	456	456	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:18669648;Dbxref=PMID:18669648
P19525	416	459	456	456	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:18669648;Dbxref=PMID:18669648
P19525	262	302	263	303	Alternative sequence	ID=VSP_046177;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.7
P19525	303	355	263	303	Alternative sequence	ID=VSP_046177;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.7
P19525	262	302	263	303	Alternative sequence	ID=VSP_046177;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.7
P19525	303	355	263	303	Alternative sequence	ID=VSP_046177;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.7
P19525	416	459	428	428	Natural variant	ID=VAR_040474;Note=V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs56219559,PMID:17344846
P19525	416	459	428	428	Natural variant	ID=VAR_040474;Note=V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs56219559,PMID:17344846
P19525	416	459	439	439	Natural variant	ID=VAR_040475;Note=In a lung adenocarcinoma sample%3B somatic mutation. L->V;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=PMID:17344846
P19525	416	459	439	439	Natural variant	ID=VAR_040475;Note=In a lung adenocarcinoma sample%3B somatic mutation. L->V;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=PMID:17344846
P19525	493	511	506	506	Natural variant	ID=VAR_040476;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs34821155,PMID:17344846
P19525	493	511	506	506	Natural variant	ID=VAR_040476;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs34821155,PMID:17344846
P19525	241	261	242	242	Mutagenesis	Note=Moderate loss of activity%3B when associated with A-255 and A-258. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:11152499;Dbxref=PMID:11152499
P19525	241	261	242	242	Mutagenesis	Note=Moderate loss of activity%3B when associated with A-255 and A-258. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:11152499;Dbxref=PMID:11152499
P19525	241	261	244	296	Mutagenesis	Note=Loss of activity. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:11337501;Dbxref=PMID:11337501
P19525	262	302	244	296	Mutagenesis	Note=Loss of activity. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:11337501;Dbxref=PMID:11337501
P19525	241	261	244	296	Mutagenesis	Note=Loss of activity. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:11337501;Dbxref=PMID:11337501
P19525	262	302	244	296	Mutagenesis	Note=Loss of activity. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:11337501;Dbxref=PMID:11337501
P19525	241	261	255	255	Mutagenesis	Note=Moderate loss of activity%3B when associated with A-242 and A-255. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:11152499;Dbxref=PMID:11152499
P19525	241	261	255	255	Mutagenesis	Note=Moderate loss of activity%3B when associated with A-242 and A-255. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:11152499;Dbxref=PMID:11152499
P19525	241	261	258	258	Mutagenesis	Note=Moderate loss of activity. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:11152499;Dbxref=PMID:11152499
P19525	241	261	258	258	Mutagenesis	Note=Moderate loss of activity. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:11152499;Dbxref=PMID:11152499
P19525	262	302	296	296	Mutagenesis	Note=Loss of activity. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:11152499;Dbxref=PMID:11152499
P19525	262	302	296	296	Mutagenesis	Note=Loss of activity. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:11152499;Dbxref=PMID:11152499
P19525	416	459	446	446	Mutagenesis	Note=Significant loss of activity and impairs autophosphorylation of T-451. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:11337501;Dbxref=PMID:11337501
P19525	416	459	446	446	Mutagenesis	Note=Significant loss of activity and impairs autophosphorylation of T-451. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:11337501;Dbxref=PMID:11337501
P19525	416	459	451	451	Mutagenesis	Note=Loss of activity. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:11337501;Dbxref=PMID:11337501
P19525	416	459	451	451	Mutagenesis	Note=Loss of activity. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:11337501;Dbxref=PMID:11337501
P19525	241	261	261	266	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2A19
P19525	262	302	261	266	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2A19
P19525	241	261	261	266	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2A19
P19525	262	302	261	266	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2A19
P19525	262	302	267	274	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2A19
P19525	262	302	267	274	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2A19
P19525	262	302	276	278	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2A19
P19525	262	302	276	278	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2A19
P19525	262	302	281	286	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2A19
P19525	262	302	281	286	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2A19
P19525	262	302	287	289	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2A19
P19525	262	302	287	289	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2A19
P19525	262	302	292	299	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2A19
P19525	262	302	292	299	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2A19
P19525	303	355	303	305	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2A19
P19525	303	355	303	305	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2A19
P19525	303	355	306	314	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2A19
P19525	303	355	306	314	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2A19
P19525	303	355	323	332	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2A19
P19525	303	355	323	332	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2A19
P19525	416	459	417	419	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2A19
P19525	416	459	417	419	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2A19
P19525	416	459	420	424	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2A19
P19525	416	459	420	424	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2A19
P19525	416	459	427	430	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2A19
P19525	416	459	427	430	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2A19
P19525	416	459	437	440	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2A19
P19525	416	459	437	440	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2A19
P19525	416	459	457	461	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2A19
P19525	416	459	457	461	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2A19
P19525	493	511	488	499	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2A19
P19525	493	511	488	499	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2A19
P19525	493	511	505	507	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3UIU
P19525	493	511	505	507	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3UIU
P19525	493	511	509	518	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2A19
P19525	493	511	509	518	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2A19

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
STAD	EIF2AK2	1.17314276574861	0.00315681146457791
CHOL	EIF2AK2	-2.82494960203243	0.00390625
ESCA	EIF2AK2	2.65103482467344	0.0048828125

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type

Gene

Coefficient

Pvalue

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with EIF2AK2 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
KICH	IUPHAR	EIF2AK2	VRK2	0.849760506	1.77E-26
KICH	Kinase	EIF2AK2	VRK2	0.849760506	1.77E-26
KIRP	IUPHAR	EIF2AK2	MAP3K2	0.814088185	9.45E-78
KIRP	IUPHAR	EIF2AK2	SLC30A6	0.847385385	2.95E-90
KIRP	Kinase	EIF2AK2	MAP3K2	0.814088185	9.45E-78
LGG	CGC	EIF2AK2	ELK4	0.803287433	6.43E-121
LGG	IUPHAR	EIF2AK2	FER	0.801755731	3.99E-120
LGG	IUPHAR	EIF2AK2	MAP3K2	0.80935679	3.95E-124
LGG	Kinase	EIF2AK2	FER	0.801755731	3.99E-120
LGG	Kinase	EIF2AK2	MAP3K2	0.80935679	3.95E-124
LGG	TF	EIF2AK2	ELK4	0.803287433	6.43E-121
PRAD	CGC	EIF2AK2	STRN	0.826832914	4.57E-139
THCA	IUPHAR	EIF2AK2	MAP3K2	0.803448776	1.77E-130
THCA	Kinase	EIF2AK2	MAP3K2	0.803448776	1.77E-130

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
LUSC	EIF2AK2	TRAF6	-2.29115964763289	0.000161412473735354
PRAD	EIF2AK2	EIF2A	-1.38148128794382	0.000229812408986035
PRAD	EIF2AK2	USP18	-1.9586919475123	0.000255755140434546
BLCA	EIF2AK2	TRAF6	-2.30263803081478	0.00141143798828125
LIHC	EIF2AK2	USP18	-3.98953218231934	0.00188131470650586
COAD	EIF2AK2	TRAF6	-1.60798701605674	0.00390031933784485
COAD	EIF2AK2	IFIT1	1.78313638394662	0.00427913665771485
LUAD	EIF2AK2	EIF2A	-2.46315879527016	0.00598625106474388
COAD	EIF2AK2	USP18	-1.8266960542629	0.00613072514533998
BRCA	EIF2AK2	IFIT1	1.4319285254122	0.00655681671575513
PRAD	EIF2AK2	TRAF6	1.56294665464259	0.00674237731133815
LUAD	EIF2AK2	IFIT1	-4.00094581635807	0.00689072947745933
KIRP	EIF2AK2	DNAJC3	-3.44412351904465	0.0132303284481168
ESCA	EIF2AK2	USP18	-1.87598879187019	0.013671875
LUAD	EIF2AK2	HERC5	-1.47536347689922	0.0147345061083731
UCEC	EIF2AK2	TP53	2.03295038376694	0.015625
THCA	EIF2AK2	HERC5	-2.65889372566435	0.0179673415067429
LUSC	EIF2AK2	USP18	2.16027475861032	0.0213811133277444
KIRP	EIF2AK2	TRAF6	-1.87658038696667	0.0216239951550961
LIHC	EIF2AK2	EIF2A	-2.84732374178848	0.0257535927654766
COAD	EIF2AK2	PRKRA	-1.69739594188574	0.0291509032249451
UCEC	EIF2AK2	PRKRA	2.58629000215781	0.03125
READ	EIF2AK2	TRAF6	-2.96141377760608	0.03125
BRCA	EIF2AK2	HERC5	-2.23955287179744	0.0338487465004179
CHOL	EIF2AK2	PRKRA	-1.65742796750198	0.0390625
HNSC	EIF2AK2	TRAF6	-1.12615956978223	0.043580235555055
KICH	EIF2AK2	USP18	2.28476039892982	1.13248825073242e-06
KIRP	EIF2AK2	IFIT1	-6.60565201257994	1.60322524607182e-05
THCA	EIF2AK2	DNAJC3	-2.12121976415638	2.19889745410215e-07
LUSC	EIF2AK2	STAT3	-1.0616935152134	2.622390634108e-05
KIRC	EIF2AK2	STAT3	-1.71331361645034	3.24635122520647e-05
BRCA	EIF2AK2	EIF2A	-1.00246114087146	3.54290594354354e-05
LIHC	EIF2AK2	TRAF6	2.43155284047127	3.59406613648813e-06
KIRC	EIF2AK2	TP53	-1.43050981150632	4.58942580328929e-09
THCA	EIF2AK2	TP53	-1.81960143635647	6.18215597921662e-07
BRCA	EIF2AK2	TRAF6	-1.39718877677468	6.90523493897062e-18

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with EIF2AK2

DBNL, FANCC, PRKRIP1, STAT1, PPP1CA, PRKRA, TP53, ILF3, METAP2, DNAJC3, PPP2R5A, ILF2, EIF2AK2, TARBP2, MAP3K5, CHUK, IKBKB, HIST2H2AC, PDGFRB, STAT3, EIF2S1, DHX58, CCNA2, DHX9, DICER1, EDC4, STAU2, ZNF346, STAU1, CCDC124, CDK3, EBNA1BP2, FARSB, FTSJ3, GLTSCR2, IFRD1, NOC3L, PPP1CC, DHX30, EIF6, FARSA, GNL3, GTPBP4, HIST1H1C, HNRNPC, HNRNPCL1, KCTD17, LYAR, MOV10, NOP2, PABPC4, PURA, SSB, TOLLIP, TOP1, XRN2, MAVS, HDGF, ELAVL1, MAP3K7, ISG15, CUL3, CAND1, ATP6V1F, JAK1, TYK2, Jak2, HSP90AA1, IL7R, gag, NPM1, EIF2A, PTGES3, HECW2, IGF2BP3, IGF2BP2, EGFR, TRAF5, TRAF6, TRAF2, SUI2, CYP1A1, NTRK1, IFI16, SCARB2, RPL10, ELMSAN1, CDCA5, CHMP4B, Kif18b, Rrbp1, MACROD1, MCM2, CDC37, PRKRIR, HIST1H2AB, MECP2, GPX7, IQCF1, PTEN, RPL6, RPLP0, RPS2, RPS3A, LMNA, COX15, DLD, DLST, TRIP4, PCBP1, EFTUD2, ESR2, LARP7, RECQL4, MYC, YGR054W, PHB, TPT1, NR2C2, HDAC2, NHLRC2, SNRNP70, Dppa3, BIRC3, BRD7, SUMO1, SUMO2, UBE2I, TRIM28, ADARB1, OBSL1, PLEKHA4, MIRLET7A1, MIRLET7A2, MIRLET7A3, MIRLET7B, MIRLET7C, MIRLET7D, MIRLET7E, MIRLET7F1, MIRLET7F2, MIRLET7G, MIRLET7I, MIR98, MIR1-1, MIR1-2, MIR7-1, MIR7-2, MIR7-3, MIR9-1, MIR9-2, MIR9-3, MIR10B, MIR15A, MIR15B, MIR16-1, MIR16-2, MIR17, MIR18A, MIR18B, MIR19A, MIR19B1, MIR19B2, MIR20A, MIR20B, MIR21, MIR25, MIR29A, MIR29B1, MIR29B2, MIR29C, MIR31, MIR34A, MIR34B, MIR34C, MIR92A1, MIR92A2, MIR93, MIR106A, MIR106B, MIR107, MIR122, MIR128-1, MIR128-2, MIR138-1, MIR138-2, MIR140, MIR141, MIR143, MIR145, MIR155, MIR199A1, MIR199A2, MIR200A, MIR200B, MIR200C, MIR205, MIR206, MIR214, MIR221, MIR222, MIR363, MIR429, MIR451A, ZC3H18, TRADD, N, ESR1, GRSF1, CIT, C12orf65, CHCHD1, FASTKD2, ICT1, MTERF3, MTRF1, RPUSD4, TBRG4, TRUB2, INS, CDC42, BRD4, NUPR1, Apc2, MKRN1, OGT, UFL1, DDRGK1, COIL, FZR1, GCH1, RPS16, KAL1, PRKY, HNRNPCL2, FNDC8, RPL35A, CCT8L2, MRPL42, METTL21B, PSG11, RFXANK, ZC3H3, HIST1H1E, FAM96A, USP32, IFNA14, RRP8, SURF6, HIST1H2AM, RPL19, SENP3, TRIM35, UBXN6, BTF3, nsp1, FBXW7, Adar, ADAR, MAP2K6, TRS1, IRS1, G3BP1, CAPRIN1, DUS2, RPL18, DDX58,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
EIF2AK2	chr2	37336434	G	C	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	Global_developmental_delay\|Leukoencephalopathy\|Developmental_regression\|Leukoencephalopathy,_developmental_delay,_and_episodic_neurologic_regression_syndrome	SO:0001583\|missense_variant	SO:0001583\|missense_variant
EIF2AK2	chr2	37349743	C	T	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	Cognitive_impairment\|Leukoencephalopathy,_developmental_delay,_and_episodic_neurologic_regression_syndrome	SO:0001583\|missense_variant	SO:0001583\|missense_variant
EIF2AK2	chr2	37353464	A	G	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant	SO:0001819\|synonymous_variant,SO:0001627\|intron_variant
EIF2AK2	chr2	37366838	T	C	single_nucleotide_variant	Likely_pathogenic	Leukoencephalopathy,_developmental_delay,_and_episodic_neurologic_regression_syndrome	SO:0001583\|missense_variant	SO:0001583\|missense_variant
EIF2AK2	chr2	37366892	T	A	single_nucleotide_variant	Uncertain_significance	EIF2AK2-related_condition\|Leukoencephalopathy,_developmental_delay,_and_episodic_neurologic_regression_syndrome\|Inborn_genetic_diseases	SO:0001583\|missense_variant	SO:0001583\|missense_variant
EIF2AK2	chr2	37368759	G	A	single_nucleotide_variant	Uncertain_significance	Global_developmental_delay\|Leukoencephalopathy\|Developmental_regression\|Leukoencephalopathy,_developmental_delay,_and_episodic_neurologic_regression_syndrome	SO:0001583\|missense_variant	SO:0001583\|missense_variant
EIF2AK2	chr2	37368760	C	A	single_nucleotide_variant	Uncertain_significance	Leukoencephalopathy,_developmental_delay,_and_episodic_neurologic_regression_syndrome	SO:0001583\|missense_variant	SO:0001583\|missense_variant
EIF2AK2	chr2	37368795	G	A	single_nucleotide_variant	Uncertain_significance	Global_developmental_delay\|Leukoencephalopathy\|Developmental_regression\|Leukoencephalopathy,_developmental_delay,_and_episodic_neurologic_regression_syndrome	SO:0001583\|missense_variant	SO:0001583\|missense_variant
EIF2AK2	chr2	37374855	T	C	single_nucleotide_variant	Uncertain_significance	Leukoencephalopathy,_developmental_delay,_and_episodic_neurologic_regression_syndrome	SO:0001583\|missense_variant	SO:0001583\|missense_variant
EIF2AK2	chr2	37374919	T	G	single_nucleotide_variant	Uncertain_significance	EIF2AK2-related_condition\|Leukoencephalopathy,_developmental_delay,_and_episodic_neurologic_regression_syndrome	SO:0001583\|missense_variant	SO:0001583\|missense_variant
EIF2AK2	chr2	37376291	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
EIF2AK2	UCEC	chr2	37374085	37374085	C	A	Nonsense_Mutation	p.E51*	6
EIF2AK2	KIRP	chr2	37365711	37365711	G	A	Silent	p.S178S	4
EIF2AK2	PAAD	chr2	37365484	37365484	C	A	Missense_Mutation	p.G206C	3
EIF2AK2	PAAD	chr2	37365423	37365423	G	A	Missense_Mutation	p.S226L	3
EIF2AK2	UVM	chr2	37349797	37349797	G	A	Missense_Mutation	p.R307C	3
EIF2AK2	LUAD	chr2	37349801	37349801	C	A	Silent	p.A305A	3
EIF2AK2	UCEC	chr2	37334649	37334649	C	A	Missense_Mutation	p.G501C	3
EIF2AK2	COAD	chr2	37374042	37374042	T	-	Frame_Shift_Del	p.N65fs	3
EIF2AK2	SKCM	chr2	37365703	37365703	G	A	Missense_Mutation	p.S181F	3
EIF2AK2	ESCA	chr2	37368815	37368815	C	T	Silent	p.T90	3
EIF2AK2	SKCM	chr2	37366820	37366820	G	A	Missense_Mutation	p.A157V	3
EIF2AK2	UCEC	chr2	37336399	37336399	C	T	Missense_Mutation	p.A473T	3
EIF2AK2	STAD	chr2	37353552	37353552	A	G	Missense_Mutation	p.F263S	2
EIF2AK2	BLCA	chr2	37374019	37374019	C	G	Missense_Mutation	p.E73Q	2
EIF2AK2	UCEC	chr2	37336408	37336408	C	A	Missense_Mutation	p.D470Y	2
EIF2AK2	LIHC	chr2	37353539	37353539	A	-	Frame_Shift_Del	p.F267fs	2
EIF2AK2	SKCM	chr2	37374849	37374849	C	T	Missense_Mutation	p.G34E	2
EIF2AK2	UVM	chr2	37349797	37349797	G	A	Missense_Mutation		2
EIF2AK2	STAD	chr2	37347260	37347260	T	C	Missense_Mutation	p.I364V	2
EIF2AK2	BLCA	chr2	37365489	37365489	G	C	Missense_Mutation	p.S204C	2
EIF2AK2	UCEC	chr2	37347267	37347267	G	A	Silent	p.C361	2
EIF2AK2	LIHC	chr2	37365699	37365699	A	-	Frame_Shift_Del	p.F182fs	2
EIF2AK2	BLCA	chr2	37366873	37366873	C	T	Silent	p.Q139Q	2
EIF2AK2	LIHC	chr2	37368735	37368735	T	-	Frame_Shift_Del	p.N117fs	2
EIF2AK2	UCEC	chr2	37347276	37347276	C	A	Missense_Mutation	p.K358N	2
EIF2AK2	LIHC	chr2	37349804	37349804	C	A	Missense_Mutation		2
EIF2AK2	UCEC	chr2	37353432	37353432	T	A	Missense_Mutation	p.E303V	2
EIF2AK2	THCA	chr2	37334481	37334481	C	T	Missense_Mutation	p.E531K	2
EIF2AK2	SKCM	chr2	37353503	37353503	G	A	Silent	p.G279G	2
EIF2AK2	UCEC	chr2	37353450	37353450	C	T	Missense_Mutation	p.R297H	2
EIF2AK2	SKCM	chr2	37362678	37362678	G	A	Missense_Mutation	p.P245L	2
EIF2AK2	UCEC	chr2	37365692	37365692	T	C	Missense_Mutation	p.T185A	2
EIF2AK2	HNSC	chr2	37347201	37347201	G	A	Silent	p.G383G	2
EIF2AK2	CESC	chr2	37349711	37349711	C	T	Silent		2
EIF2AK2	UCEC	chr2	37368752	37368752	C	A	Missense_Mutation	p.K111N	2
EIF2AK2	STAD	chr2	37362652	37362652	C	T	Missense_Mutation		2
EIF2AK2	CESC	chr2	37365709	37365709	G	A	Missense_Mutation		2
EIF2AK2	UCEC	chr2	37368810	37368810	G	T	Missense_Mutation	p.S92Y	2
EIF2AK2	STAD	chr2	37362652	37362652	C	T	Missense_Mutation	p.E254K	2
EIF2AK2	KIRC	chr2	37366825	37366825	T	G	Missense_Mutation	p.Q155H	2
EIF2AK2	PAAD	chr2	37365484	37365484	C	A	Missense_Mutation		2
EIF2AK2	CESC	chr2	37365460	37365460	C	G	Missense_Mutation		2
EIF2AK2	LIHC	chr2	37334620	37334620	T	-	Frame_Shift_Del	p.K510fs	2
EIF2AK2	SKCM	chr2	37334419	37334419	A	G	Silent	p.C551C	2
EIF2AK2	UCEC	chr2	37373999	37373999	C	A	Missense_Mutation	p.K79N	2
EIF2AK2	STAD	chr2	37364140	37364140	T	C	Silent	p.Q236Q	2
EIF2AK2	BLCA	chr2	37374916	37374916	C	G	Missense_Mutation	p.E12Q	2
EIF2AK2	KIRC	chr2	37368712	37368712	C	-	Frame_Shift_Del	p.V125fs	2
EIF2AK2	UCEC	chr2	37334619	37334619	C	A	Nonsense_Mutation	p.E511*	2
EIF2AK2	LIHC	chr2	37347254	37347254	T	-	Frame_Shift_Del	p.M366fs	2
EIF2AK2	LUAD	chr2	37349652	37349652	G	C	Nonsense_Mutation	p.S355*	2
EIF2AK2	STAD	chr2	37365428	37365428	A	C	Missense_Mutation	p.S224R	2
EIF2AK2	UCEC	chr2	37336400	37336400	G	A	Silent	p.Y472	2
EIF2AK2	LIHC	chr2	37349658	37349658	T	-	Frame_Shift_Del	p.N353fs	2
EIF2AK2	SKCM	chr2	37374038	37374038	G	A	Silent	p.A66A	2
EIF2AK2	UCEC	chr2	37374883	37374883	C	T	Missense_Mutation	p.V23I	2
EIF2AK2	LUAD	chr2	37347280	37347280	G	A	Missense_Mutation	p.S357L	1
EIF2AK2	KIRP	chr2	37365711	37365711	G	A	Silent		1
EIF2AK2	CESC	chr2	37365460	37365460	C	G	Missense_Mutation	p.E214Q	1
EIF2AK2	BLCA	chr2	37374916	37374916	C	G	Missense_Mutation		1
EIF2AK2	GBM	chr2	37347227	37347227	C	T	Missense_Mutation		1
EIF2AK2	LUAD	chr2	37349800	37349800	C	A	Nonsense_Mutation	p.E306*	1
EIF2AK2	LGG	chr2	37374066	37374066	C	T	Missense_Mutation	p.G57D	1
EIF2AK2	CESC	chr2	37365709	37365709	G	A	Missense_Mutation	p.S179F	1
EIF2AK2	BLCA	chr2	37362656	37362656	C	T	Missense_Mutation		1
EIF2AK2	HNSC	chr2	37341881	37341881	G	T	Missense_Mutation		1
EIF2AK2	SKCM	chr2	37374039	37374039	G	A	Missense_Mutation	p.A66V	1
EIF2AK2	STAD	chr2	37347136	37347136	A	G	Missense_Mutation	p.I405T	1
EIF2AK2	LIHC	chr2	37336403	37336403	G	C	Silent		1
EIF2AK2	CESC	chr2	37334416	37334416	C	G	Nonstop_Mutation	p.*552Y	1
EIF2AK2	SARC	chr2	37336398	37336398	G	T	Missense_Mutation		1
EIF2AK2	BLCA	chr2	37374019	37374019	C	G	Missense_Mutation		1
EIF2AK2	HNSC	chr2	37347201	37347201	G	A	Silent		1
EIF2AK2	SKCM	chr2	37349786	37349786	T	C	Silent	p.K310K	1
EIF2AK2	LUAD	chr2	37365452	37365452	A	G	Silent	p.N216N	1
EIF2AK2	STAD	chr2	37334430	37334430	G	A	Nonsense_Mutation	p.R548*	1
EIF2AK2	BLCA	chr2	37366800	37366800	G	A	Nonsense_Mutation	p.Q164*	1
EIF2AK2	COAD	chr2	37334666	37334666	A	-	Frame_Shift_Del	p.F495fs	1
EIF2AK2	LIHC	chr2	37368792	37368792	A	-	Frame_Shift_Del	p.M98fs	1
EIF2AK2	SKCM	chr2	37334636	37334637	TC	-	Frame_Shift_Del	p.505_505del	1
EIF2AK2	BLCA	chr2	37365489	37365489	G	C	Missense_Mutation		1
EIF2AK2	HNSC	chr2	37368770	37368770	G	C	Missense_Mutation		1
EIF2AK2	SKCM	chr2	37362671	37362671	A	G	Silent	p.F247F	1
EIF2AK2	LUAD	chr2	37365665	37365665	C	A	Missense_Mutation	p.V194L	1
EIF2AK2	BLCA	chr2	37336341	37336341	G	C	Nonsense_Mutation	p.S492*	1
EIF2AK2	LIHC	chr2	37334471	37334471	C	A	Missense_Mutation		1
EIF2AK2	COAD	chr2	37368716	37368716	C	T	Silent	p.S123S	1
EIF2AK2	LIHC	chr2	37347146	37347146	C	-	Frame_Shift_Del	p.V402fs	1
EIF2AK2	BLCA	chr2	37366873	37366873	C	T	Silent		1
EIF2AK2	HNSC	chr2	37368770	37368770	G	C	Missense_Mutation	p.I105M	1
EIF2AK2	SKCM	chr2	37347186	37347187	TT	-	Frame_Shift_Del	p.K388fs	1
EIF2AK2	LUAD	chr2	37349800	37349801	CC	AA	Nonsense_Mutation	p.E306*	1
EIF2AK2	BLCA	chr2	37368823	37368823	T	C	Missense_Mutation	p.T88A	1
EIF2AK2	LIHC	chr2	37349761	37349761	T	C	Missense_Mutation		1
EIF2AK2	LIHC	chr2	37364127	37364127	T	-	Splice_Site	p.R241_splice	1
EIF2AK2	SKCM	chr2	37334636	37334637	TC	-	Frame_Shift_Del	p.D505fs	1
EIF2AK2	BLCA	chr2	37374063	37374063	C	G	Missense_Mutation		1
EIF2AK2	OV	chr2	37341969	37341969	C	T	Missense_Mutation	p.V428I	1
EIF2AK2	UCEC	chr2	37336400	37336400	G	A	Silent	p.Y472Y	1
EIF2AK2	LIHC	chr2	37349710	37349710	T	C	Missense_Mutation	p.T336A	1
EIF2AK2	DLBC	chr2	37353464	37353464	A	G	Silent	p.T292T	1
EIF2AK2	LIHC	chr2	37366828	37366828	T	-	Frame_Shift_Del	p.K154fs	1
EIF2AK2	BLCA	chr2	37334476	37334476	T	C	Missense_Mutation		1
EIF2AK2	KIRC	chr2	37347219	37347219	C	G	Missense_Mutation	p.W377C	1
EIF2AK2	OV	chr2	37374945	37374945	G	C	Missense_Mutation	p.A2G	1
EIF2AK2	UCEC	chr2	37334423	37334423	G	A	Missense_Mutation	p.T550I	1
EIF2AK2	LIHC	chr2	37349804	37349804	C	A	Missense_Mutation	p.K304N	1
EIF2AK2	LIHC	chr2	37347123	37347123	T	-	Frame_Shift_Del	p.K409fs	1
EIF2AK2	BLCA	chr2	37368823	37368823	T	C	Missense_Mutation		1
EIF2AK2	ESCA	chr2	37362668	37362668	G	A	Silent	p.D248D	1
EIF2AK2	LIHC	chr2	37347181	37347181	A	-	Frame_Shift_Del	p.L390fs	1
EIF2AK2	LUAD	chr2	37366778	37366778	G	A	Missense_Mutation	p.S171L	1
EIF2AK2	PAAD	chr2	37347261	37347261	G	T	Missense_Mutation		1
EIF2AK2	CESC	chr2	37349711	37349711	C	T	Silent	p.E335E	1
EIF2AK2	ESCA	chr2	37368815	37368815	C	T	Silent	p.T90T	1
EIF2AK2	SKCM	chr2	37347186	37347187	TT	-	Frame_Shift_Del	p.388_389del	1
EIF2AK2	BLCA	chr2	37362656	37362656	C	T	Missense_Mutation	p.M252I	1
EIF2AK2	PAAD	chr2	37365423	37365423	G	A	Missense_Mutation		1
EIF2AK2	CESC	chr2	37334416	37334416	C	G	Nonstop_Mutation		1
EIF2AK2	GBM	chr2	37376027	37376027	C	T	Translation_Start_Site		1

Copy number variation (CNV) of EIF2AK2
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across EIF2AK2
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
94732	LUAD	TCGA-NJ-A55O-01A	AGR2	chr7	16832266	-	EIF2AK2	chr2	37342384	-
94732	BRCA	TCGA-E2-A1B1-01A	AHNAK	chr11	62283375	-	EIF2AK2	chr2	37342384	-
94732	LUAD	TCGA-75-7025-01A	APLP2	chr11	130014699	-	EIF2AK2	chr2	37342384	-
94732	N/A	DN995878	ARID2	chr12	46123446	-	EIF2AK2	chr2	37376169	-
94732	SKCM	TCGA-ER-A195-06A	AXIN2	chr17	63524685	-	EIF2AK2	chr2	37342384	-
94732	N/A	AI675715	BANF1	chr11	65771508	-	EIF2AK2	chr2	37327165	+
94732	LUSC	TCGA-66-2737-01A	CAPN1	chr11	64979476	-	EIF2AK2	chr2	37342384	-
94732	LUAD	TCGA-86-7954-01A	CD63	chr12	56119232	-	EIF2AK2	chr2	37342384	-
94732	LGG	TCGA-DU-6404-01A	CKB	chr14	103986004	-	EIF2AK2	chr2	37342384	-
94732	LUSC	TCGA-85-8666-01A	COL6A1	chr21	47424962	-	EIF2AK2	chr2	37342384	-
94732	BRCA	TCGA-E9-A1RD-01A	COX6C	chr8	100890379	-	EIF2AK2	chr2	37342384	-
94732	STAD	TCGA-D7-A6EZ	CREBBP	chr16	3929832	-	EIF2AK2	chr2	37353554	-
94732	LUSC	TCGA-34-5241-01A	DDIT4	chr10	74035794	-	EIF2AK2	chr2	37342384	-
94732	STAD	TCGA-BR-8484-01A	DDX17	chr22	38879445	-	EIF2AK2	chr2	37342384	-
94732	STAD	TCGA-BR-8679-01A	EEF2	chr19	3976055	-	EIF2AK2	chr2	37342384	-
99634	ESCA	TCGA-IG-A8O2	EIF2AK2	chr2	37384050	-	ABCC1	chr16	16101672	+
68823	BLCA	TCGA-FD-A3NA-01A	EIF2AK2	chr2	37362627	-	CEBPZ	chr2	37429046	-
68823	BLCA	TCGA-FD-A3NA-01A	EIF2AK2	chr2	37362627	-	CEBPZ	chr2	37430151	-
68823	BRCA	TCGA-A2-A04P	EIF2AK2	chr2	37349648	-	CEBPZ	chr2	37429046	-
68823	BRCA	TCGA-A2-A04P-01A	EIF2AK2	chr2	37349648	-	CEBPZ	chr2	37429045	-
68823	BRCA	TCGA-A2-A04P-01A	EIF2AK2	chr2	37349649	-	CEBPZ	chr2	37429046	-
68823	BRCA	TCGA-E2-A1AZ-01A	EIF2AK2	chr2	37347102	-	CEBPZ	chr2	37444180	-
94732	N/A	BU156279	EIF2AK2	chr2	37329450	-	EIF2AK2	chr2	37330157	-
94700	N/A	AW149070	EIF2AK2	chr2	37333939	+	FAM213A	chr10	82192121	-
94388	BRCA	TCGA-D8-A142-01A	EIF2AK2	chr2	37362627	-	RMDN2	chr2	38216684	+
97549	BRCA	TCGA-OL-A5D8-01A	EIF2AK2	chr2	37341874	-	STRN	chr2	37152351	-
94732	THCA	TCGA-CE-A483-01A	EIF4G2	chr11	10818601	-	EIF2AK2	chr2	37342384	-
94732	STAD	TCGA-BR-A44T-01A	FLNA	chrX	153576900	-	EIF2AK2	chr2	37342384	-
94732	BRCA	TCGA-A8-A097-01A	FN1	chr2	216225163	-	EIF2AK2	chr2	37342384	-
94732	BRCA	TCGA-B6-A0IM-01A	GLUL	chr1	182352029	-	EIF2AK2	chr2	37342384	-
94732	PCPG	TCGA-QT-A5XJ-01A	GNAS	chr20	57486241	-	EIF2AK2	chr2	37342384	-
94732	KIRP	TCGA-5P-A9KC-01A	GPX3	chr5	150408554	-	EIF2AK2	chr2	37342384	-
94732	BLCA	TCGA-GC-A3WC-01A	HLA-B	chr6	31321649	-	EIF2AK2	chr2	37342384	-
94732	BLCA	TCGA-DK-A6B2-01A	HLA-C	chr6	31236528	-	EIF2AK2	chr2	37342384	-
94732	READ	TCGA-AF-2687-01A	IGF2	chr11	2150351	-	EIF2AK2	chr2	37342384	-
94732	KIRP	TCGA-G7-6793-01A	ITGA3	chr17	48167848	-	EIF2AK2	chr2	37342384	-
94732	LUSC	TCGA-85-8582-01A	JUP	chr17	39775692	-	EIF2AK2	chr2	37342384	-
94732	PAAD	TCGA-IB-7885-01A	KRT19	chr17	39679869	-	EIF2AK2	chr2	37342384	-
94732	LGG	TCGA-DU-6393-01A	NUMA1	chr11	71713911	-	EIF2AK2	chr2	37342384	-
94732	LUAD	TCGA-97-7552-01A	PLEC	chr8	144989321	-	EIF2AK2	chr2	37342384	-
94732	KIRC	TCGA-B4-5378-01A	RHOB	chr2	20649200	-	EIF2AK2	chr2	37342384	-
94732	KIRC	TCGA-B0-5691-01A	SDC4	chr20	43953928	-	EIF2AK2	chr2	37342384	-
94732	LUAD	TCGA-97-7547-01A	SEC61A1	chr3	127790525	-	EIF2AK2	chr2	37342384	-
94732	BRCA	TCGA-BH-A1F0-01A	SEPP1	chr5	42799982	-	EIF2AK2	chr2	37342384	-
94732	LGG	TCGA-DB-5273-01A	SEPT3	chr22	42394225	-	EIF2AK2	chr2	37342384	-
94732	BLCA	TCGA-FD-A3SQ-01A	SERINC2	chr1	31907521	-	EIF2AK2	chr2	37342384	-
94732	LIHC	TCGA-K7-A6G5-01A	SERPINA3	chr14	95090389	-	EIF2AK2	chr2	37342384	-
94732	SKCM	TCGA-EE-A2MK-06A	TIMP1	chrX	47446188	-	EIF2AK2	chr2	37342384	-
94732	STAD	TCGA-BR-8679-01A	TPT1	chr13	45911313	-	EIF2AK2	chr2	37342384	-
94732	THCA	TCGA-EL-A3T7-01A	TSC22D1	chr13	45007661	-	EIF2AK2	chr2	37342384	-
94736	KIRC	TCGA-B0-5691-01A	TSPAN1	chr1	46651630	-	EIF2AK2	chr2	37342384	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
HNSC	EIF2AK2	0.00303239160151753	0.082
STAD	EIF2AK2	0.00903978909216914	0.24
READ	EIF2AK2	0.0186977972706412	0.47
BRCA	EIF2AK2	0.0340939355008731	0.82
THYM	EIF2AK2	0.0389559520600173	0.9
TGCT	EIF2AK2	0.0395117252081561	0.9
UVM	EIF2AK2	0.0442509364570753	0.93
KIRP	EIF2AK2	2.94096132202281e-08	8.2e-07

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LIHC	EIF2AK2	0.0189054524922736	0.6
KIRP	EIF2AK2	0.0365125915524429	1
BRCA	EIF2AK2	0.0303371646880617	0.94
ESCA	EIF2AK2	0.00159116152100862	0.053
PCPG	EIF2AK2	0.0395250543118068	1

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0021400	Influenza	1	CTD_human
C0038220	Status Epilepticus	1	CTD_human
C0270823	Petit mal status	1	CTD_human
C0311335	Grand Mal Status Epilepticus	1	CTD_human
C0376358	Malignant neoplasm of prostate	1	CTD_human
C0393734	Complex Partial Status Epilepticus	1	CTD_human
C0751522	Status Epilepticus, Subclinical	1	CTD_human
C0751523	Non-Convulsive Status Epilepticus	1	CTD_human