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Center for Computational Systems Medicine
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Gene Summary

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Translation studies in PubMed

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Exon Skipping Events

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Expression

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Expression Regulation

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Associated Genes

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Protein 3D Structure

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Protein-Protein Interaction

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Mutations

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Prognostic Analysis

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Gender Association

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Age Association

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Related Drugs

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Related Diseases

Translation Factor: METTL3 (NCBI Gene ID:56339)


Gene Summary

check button Gene Summary
Gene InformationGene Name: METTL3
Gene ID: 56339
Gene Symbol

METTL3

Gene ID

56339

Gene Namemethyltransferase like 3
SynonymsIME4|M6A|MT-A70|Spo8|hMETTL3
Cytomap

14q11.2

Type of Geneprotein-coding
DescriptionN6-adenosine-methyltransferase catalytic subunitN6-adenosine-methyltransferase 70 kDa subunitadoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferasemRNA (2'-O-methyladenosine-N(6)-)-methyltransferasemRNA m(6)A methyltransferasemethy
Modification date20200322
UniProtAcc

Q86U44


check button Child GO biological process term(s) under GO:0006412
GO IDGO term
GO:0017148Negative regulation of translation
GO:0006417Regulation of translation
GO:0045727Positive regulation of translation
GO:0002181Cytoplasmic translation
GO:0006413Translational initiation
GO:0006412Translation


check button Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMETTL3

GO:0006974

cellular response to DNA damage stimulus

28297716

HgeneMETTL3

GO:0009048

dosage compensation by inactivation of X chromosome

27602518

HgeneMETTL3

GO:0031053

primary miRNA processing

25799998

HgeneMETTL3

GO:0034644

cellular response to UV

28297716

HgeneMETTL3

GO:0080009

mRNA methylation

24316715|27281194|27373337|27627798|28297716

HgeneMETTL3

GO:1990744

primary miRNA methylation

25799998



check button Inferred gene age of translation factor.
GeneInferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25


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Translation Studies in PubMed

check button We searched PubMed using 'METTL3[title] AND translation [title] AND human.'
GeneTitlePMID
METTL3New insight into the catalytic -dependent and -independent roles of METTL3 in sustaining aberrant translation in chronic myeloid leukemia34561421


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Exon Skipping Events

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.
all structure

check button Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ENSTExon skip start (DNA)Exon Skip end (DNA)ORF
ENST000002987172196744921967515In-frame
ENST000002987172196790721967946In-frame
ENST000002987172196863621968824Frame-shift
ENST000002987172196986921970045Frame-shift

check button Exon skipping position in the amino acid sequence.
ENSTExon skip start (DNA)Exon Skip end (DNA)Len(transcript seq)Exon skip start (mRNA)Exon Skip end (mRNA)Len(amino acid seq)Exon skip start (AA)Exon Skip end (AA)
ENST000002987172196744921967515203216051670580484506
ENST000002987172196790721967946203214571495580435447

check button Potentially (partially) lost protein functional features of UniProt.
UniProtAccExon skip start (AA)Exon Skip end (AA)Function feature start (AA)Function feature end (AA)Functional feature typeFunctional feature desc.
Q86U444354472580ChainID=PRO_0000207630;Note=N6-adenosine-methyltransferase catalytic subunit
Q86U444845062580ChainID=PRO_0000207630;Note=N6-adenosine-methyltransferase catalytic subunit
Q86U44435447438438Binding siteNote=Interaction with METTL14;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:5IL1,ECO:0000244|PDB:5IL2,ECO:0000269|PubMed:27281194;Dbxref=PMID:27281194
Q86U44435447441441Binding siteNote=Interaction with METTL14;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PDB:5IL1,ECO:0000244|PDB:5IL2,ECO:0000269|PubMed:27281194;Dbxref=PMID:27281194
Q86U44484506486505Alternative sequenceID=VSP_007865;Note=In isoform 2. GVKGNPQGFNQGLDCDVIVA->SSSGAQFNRWSTKKNHLISY;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
Q86U44484506506580Alternative sequenceID=VSP_007866;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
Q86U44435447436446HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IL2
Q86U44484506480489Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IL2
Q86U44484506498506Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5IL2


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Expression


check buttonGene expression level across TCGA pancancer
all structure

check buttonGene expression level across GTEx pantissue
all structure

check buttonExpression level of gene isoforms across TCGA pancancer
all structure

check buttonExpression level of gene isoforms across GTEx pantissue
all structure

check buttonCancer(tissue) type-specific expression level of Translation factor using z-score distriution
all structure

check buttonDifferential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)
all structure
Cancer typeTranslation factorFCadj.pval
CHOLMETTL3-3.319434956918480.0390625
COADMETTL3-3.542889187408572.08616256713867e-06
LIHCMETTL3-1.433814476677083.17814170396599e-08
PRADMETTL32.277776677435575.10126106041513e-07


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Expression Regulation


check buttonTranslation factor expression regulation through miRNA binding
Cancer typeGenemiRNATargetScan binding score (Context++ score percentile)CoefficientPvalue


check buttonTranslation factor expression regulation through methylation in the promoter of Translation factor
all structure
Cancer typeGenemethyl group bmethyl group aDEG pvalavg methyl in bavg methyl in aavg exp in bavg exp in a

check buttonTranslation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)
all structure
Cancer typeGenemethyl group bmethyl group aDEG pvalavg methyl in bavg methyl in aavg exp in bavg exp in a

check buttonTranslation factor expression regulation through copy number variation of Translation factor
all structure
Cancer typeGeneCoefficientPvalue
LUSCMETTL30.1030349170.043100556

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Associated Genes


check button Strongly correlated genes belong to cellular important gene groups with METTL3 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)
all structure
Cancer typeGene groupTranslation factorCorrelated geneCoefficientPvalue
DLBCTSGMETTL3PNN0.8357030561.48E-13
THYMCell metabolism geneMETTL3SRP540.8242127812.03E-31
THYMCell metabolism geneMETTL3AGK0.8299462283.33E-32
THYMTFMETTL3ZNF280C0.8053642215.02E-29
THYMTFMETTL3ZBTB10.8649967019.65E-38
THYMTSGMETTL3RINT10.8146633363.58E-30
THYMTSGMETTL3PNN0.8152514533.02E-30
UCSCell metabolism geneMETTL3SRP540.8242127812.03E-31
UCSCell metabolism geneMETTL3AGK0.8299462283.33E-32
UCSTFMETTL3ZNF280C0.8053642215.02E-29
UCSTFMETTL3ZBTB10.8649967019.65E-38
UCSTSGMETTL3RINT10.8146633363.58E-30
UCSTSGMETTL3PNN0.8152514533.02E-30


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Protein structure


check button Protein 3D structure
Visit iCn3D.


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Protein-Protein Interaction


check button Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))
all structure

check buttonOverlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))
all structure
check button
* Edge colors based on TCGA cancer types.

check button* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))
all structure
Cancer typeTranslation factorInteracting protein coding geneFCadj.pval
KICHMETTL3RBM15B-2.892249140855250.000102996826171875
KIRPMETTL3RBM15B-4.158757192174880.000280400272458792
LIHCMETTL3ZC3H132.30583158584460.000458084191609093
KIRCMETTL3RBM15-1.350077132011060.000600141235926365
COADMETTL3KIAA1429-3.394209816460750.000664144754409791
LUADMETTL3METTL14-1.435965945965230.00121089428940613
HNSCMETTL3RBM15B-2.907737605992830.00186235073124408
PRADMETTL3RBM15-1.093278079177140.00277499505363991
CHOLMETTL3RBM15B-2.367817184501140.0078125
LUADMETTL3WTAP-1.786162260908530.00791615044666943
LUADMETTL3RBM15-1.245797937291440.0103856608841715
KIRCMETTL3WTAP-2.702736604950670.0143053039058135
BLCAMETTL3WTAP-2.908819548467390.0159721374511719
PRADMETTL3ZC3H13-1.098396701766280.0176746638162561
STADMETTL3KIAA1429-1.615671032805560.020511694252491
ESCAMETTL3RBM15B-2.204014644247290.0244140625
LUADMETTL3CBLL1-1.322797215215850.0345442316474578
BRCAMETTL3RBM15B-1.210880847744220.0367624289903515
CHOLMETTL3KIAA1429-2.832292004427680.0390625
UCECMETTL3WTAP-3.786291472213770.046875
THCAMETTL3ZC3H13-7.586404109054151.49948359448794e-05
LUADMETTL3NCBP1-2.331309649484311.81586577755686e-08
THCAMETTL3KIAA14291.46880078297042.5764473552472e-05
KIRCMETTL3NCBP11.823161262394422.95519875508206e-07
THCAMETTL3METTL14-2.30919316658243.03433720687169e-07
KIRCMETTL3ZC3H13-2.508553517138925.02527105682381e-05
HNSCMETTL3RBM151.406151825693035.61373060463667e-05
THCAMETTL3WTAP-2.893924438670045.83719995580266e-05


check button Protein-protein interactors with this translation factor (BIOGRID-3.4.160)
PPI interactors with METTL3
METTL14, MOV10, HIST1H2BG, CEP19, ROBO2, SEL1L, WTAP, RBM15B, PPHLN1, MPP1, MYC, ACTR2, SNW1, NSUN2, ARNTL2, SIRT6, LGALS7, OLFM2, SMAD2, SMAD3, HSPA8, KRT1, KRT2, HSPA1A, KRT10, KRT9, TUBB, KRT5, TUBA1C, HSPA9, KRT14, KRT16, ALB, ACTB, ANXA2, HSPA5, TUFM, EEF1A1, ACTC1, UBC, IGHG1, LMNA, HNRNPH1, VIM, DSP, DDX5, IGKV1-5, CASP14, HIST4H4, DCD, PCBP2, ZC3H13, CBLL1, HRNR, C4A, HIST1H2BK, PRDX2, COL14A1, FLG2, C18orf63, LSM4, TXN, PRSS3, C1orf68, BRMS1, HNRNPK, HNRNPU, KIAA1429, METTL3, TRIM28, CCT2, CCT7, CCT3, CCT8, TCP1, CCT6A, CCT5, CCT4, TUBB4B, DNAJA1, HSP90AA1, DNAJA2, HSP90AB1, BAG2, WRNIP1, HSPD1, HNRNPR, NPM1, PTBP1, DDX3Y, CUL2, SYNCRIP, RPL23, MATR3, HNRNPF, KRT72, NONO, MCM3, KRT18, PRAME, DSG1, CDKN2A, IGHG2, FUS, SF3B2, TCEB1, HUWE1, SNRNP200, LTF, SFPQ, EIF4B, HNRNPA3, VCP, RPS14, SNRPD3, RPL24, EWSR1, DSC1, TARDBP, BTN1A1, HNRNPD, PCBP1, RBBP7, PRMT1, PUF60, THRAP3, KHDRBS3, GAPDH, SNRNP70, XRCC6, EEF2, SNRPB, ATP5A1, U2AF2, RPL13, HNRNPM, RPS26, PRKDC, SRSF2, C1QBP, ILF2, TCEB2, KRT6A, UBR5, DDX39A, MSH2, HNRNPCL1, CSTA, ANXA1, DYNLL1, H3F3C, RBM15, TUBB2A, HSPH1, TUBB4A, TUBA4A, DNAJC7, RUVBL2, RUVBL1, CCAR2, BAG5, DDX3X, POLD1, STIP1, BAG6, PSMC5, HSPA4, DDB1, DNAJB4, DNAJB1, PSMC1, HDAC2, KRT84, TMPO, FASN, MSH6, AMBRA1, HSPBP1, TUBAL3, HSPA4L, IMPDH2, PSMC4, PFKP, ARID5B, PSMC3, ARFIP2, PSMC6, HDAC1, TMEM200B, BAG1, PRMT5, PHGDH, HTATSF1, NUDT21, DNAJB6, KCNH1, ACAT1, CAD, LYZ, RPL38, MLF2, TBR1, C1orf167, AFMID, TBC1D10C, CD302, PRPF31, RAPGEF4, DDB2, WDR77, TSEN34, UCKL1, DMBT1, GTF3C4, VPS4A, STUB1, GTF3C5, NFIB, NDUFAB1, RYR1, CDK9, GTF2I, KHSRP, GNL3, SPATA5L1, TBL1XR1, XRN2, AKAP8L, PSMD13, BAG3, ZRANB2, NCBP1, EIF3G, EIF3I, EIF3J, EIF3M, EIF3H, EIF3B, EIF4E, MTDH, ESR1, EIF4A3, ECT2, UCHL1, BRD4, MAPK1, MAPK3, MAPK14, MAPK8, USP5, TERF2IP, WDR5, LMNB2, SNAPC4, SPANXN4, SHARPIN, SPANXN5, PIAS4, NUP210P1, FUBP1, BRD2,


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Mutations


check button Clinically associated variants from ClinVar.
GeneChrPositionRefSeqVarSeqRefSeeqVarTypePathogenicDiseaseVarInfo


check button nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.
all structure


check button SNVs and Indels
GeneCancer typeChromosomeStartEndRefSeeqMutSeqMutation typeAAchange# samples
METTL3CESCchr142196791621967916AGSilent8
METTL3BLCAchr142196767621967676CTMissense_Mutationp.R471H4
METTL3BLCAchr142196720621967206CTMissense_Mutation4
METTL3ESCAchr142196988621969886GAMissense_Mutationp.R295C3
METTL3HNSCchr142196908721969087CTMissense_Mutationp.D362N3
METTL3SKCMchr142196727821967278GAMissense_Mutationp.R508C3
METTL3PAADchr142197146721971467GAMissense_Mutationp.A191V3
METTL3UCECchr142196745921967459GASilentp.I5032
METTL3LAMLchr142104912321049123TCMissense_Mutationp.Q28R2
METTL3COADchr142197169421971694CASilentp.G115G2
METTL3UCECchr142196792721967927CANonsense_Mutationp.E442*2
METTL3BLCAchr142196725421967254CTMissense_Mutation2
METTL3PRADchr142197136521971365ACNonstop_Mutationp.*154E2
METTL3LGGchr142197199021971990GASilentp.T45T2
METTL3UCECchr142196924221969242GTMissense_Mutationp.S310Y2
METTL3HNSCchr142197172121971721CASplice_Site2
METTL3STADchr142196644221966442CAMissense_Mutationp.R568M2
METTL3UCECchr142197148821971488GAMissense_Mutationp.S184L2
METTL3LGGchr142196879521968795GASilentp.D382D2
METTL3STADchr142197137221971372GASilentp.L223L2
METTL3ESCAchr142197193321971933GTMissense_Mutationp.S64R2
METTL3UCECchr142197160121971601GTSilentp.T1462
METTL3BLCAchr142196767621967676CTMissense_Mutation2
METTL3BLCAchr142196720621967206CGMissense_Mutationp.E532Q2
METTL3ESCAchr142196988621969886GAMissense_Mutation2
METTL3BRCAchr142196727821967278GCMissense_Mutationp.R508G2
METTL3THYMchr142197182821971828GTSilent2
METTL3BLCAchr142196773121967731CTMissense_Mutationp.D453N2
METTL3HNSCchr142197133321971333CTMissense_Mutationp.E236K2
METTL3BRCAchr142196876421968764TCMissense_Mutationp.M393V2
METTL3BLCAchr142197936521979365TCTranslation_Start_Sitep.M1V2
METTL3SARCchr142196764221967642GASilent2
METTL3SKCMchr142196749621967496GAMissense_Mutationp.P491L2
METTL3UCECchr142196640721966407ACMissense_Mutationp.L580V2
METTL3BLCAchr142196725421967254CTMissense_Mutationp.E516K2
METTL3BLCAchr142196768521967685CTMissense_Mutationp.R468Q2
METTL3PAADchr142197146721971467GAMissense_Mutation2
METTL3UCECchr142196727721967277CTMissense_Mutationp.R508H2
METTL3KIRPchr142197933521979335GTMissense_Mutation1
METTL3SKCMchr142197003521970035TCMissense_Mutationp.E245G1
METTL3BLCAchr142196725721967257CAMissense_Mutation1
METTL3COADchr142196643921966439TCMissense_Mutationp.Y569C1
METTL3LIHCchr142196991621969916TCMissense_Mutation1
METTL3BLCAchr142196922321969223GCMissense_Mutationp.F316L1
METTL3HNSCchr142197193321971933GASilent1
METTL3BLCAchr142197146121971461GAMissense_Mutation1
METTL3BLCAchr142196998521969985CTMissense_Mutationp.E262K1
METTL3HNSCchr142196918321969183GAMissense_Mutationp.H330Y1
METTL3PRADchr142197136521971365ACMissense_Mutationp.I225R1
METTL3SKCMchr142196641921966422TAGA-Frame_Shift_Delp.SK575fs1
METTL3BLCAchr142196998521969985CTMissense_Mutation1
METTL3LIHCchr142196719421967194GTSilent1
METTL3BLCAchr142196875021968750GCSilentp.P397P1
METTL3HNSCchr142196721521967215GAMissense_Mutation1
METTL3BLCAchr142196726021967260GTMissense_Mutationp.P514T1
METTL3HNSCchr142196721521967215GAMissense_Mutationp.R529C1
METTL3STADchr142196644221966442CAMissense_Mutation1
METTL3BLCAchr142196726021967260GTMissense_Mutation1
METTL3COADchr142197199221971992TCMissense_Mutationp.T45A1
METTL3LIHCchr142197001721970017T-Frame_Shift_Delp.N251fs1
METTL3BLCAchr142196875021968750GCSilent1
METTL3BLCAchr142196745221967452CTMissense_Mutationp.E506K1
METTL3KIRCchr142196747321967473CGMissense_Mutationp.D499H1
METTL3PRADchr142196923021969230CGMissense_Mutationp.C314S1
METTL3LGGchr142197154521971545CTMissense_Mutationp.G165D1
METTL3BLCAchr142196726421967264ACMissense_Mutation1
METTL3LUADchr142196906721969067GCSilentp.L368L1
METTL3BLCAchr142196921821969218TAMissense_Mutationp.N318I1
METTL3BLCAchr142196922321969223GCMissense_Mutation1
METTL3BLCAchr142196726421967264ACMissense_Mutationp.H512Q1
METTL3KIRCchr142196649221966492CTSilentp.L551L1
METTL3PRADchr142196790921967909CASplice_Sitep.G448W1
METTL3BLCAchr142196745221967452CTMissense_Mutation1
METTL3LUADchr142196772021967720ACMissense_Mutationp.I456M1
METTL3BLCAchr142197165121971651CANonsense_Mutationp.E130*1
METTL3HNSCchr142197193321971933GASilentp.S64S1
METTL3KIRCchr142196744921967449CGSplice_Site.1
METTL3READchr142197145421971454GASilentp.V195V1
METTL3LGGchr142197150721971507GAMissense_Mutationp.R178W1
METTL3TGCTchr142196767721967677GAMissense_Mutation1
METTL3BLCAchr142196907221969072GANonsense_Mutationp.R367*1
METTL3LUADchr142197195221971952GAMissense_Mutationp.S58F1
METTL3BLCAchr142197201021972010CTMissense_Mutationp.E39K1
METTL3HNSCchr142197190621971906ATSilentp.A73A1
METTL3BLCAchr142196921821969218TAMissense_Mutation1
METTL3KIRCchr142196751221967512CTMissense_Mutationp.G486S1
METTL3READchr142196720221967202AGMissense_Mutationp.L533S1
METTL3LGGchr142196750621967506TCMissense_Mutationp.K488E1
METTL3GBMchr142196922221969222GTMissense_Mutation1
METTL3LUADchr142197172221971722TCSplice_Sitep.P107_splice1
METTL3BLCAchr142197184421971844GAMissense_Mutationp.P94L1
METTL3BLCAchr142197184421971844GAMissense_Mutation1
METTL3KIRCchr142196764721967647CTMissense_Mutationp.E481K1
METTL3SARCchr142196871621968716GTMissense_Mutation1
METTL3LGGchr142197140421971406TTC-In_Frame_Delp.KK211del1
METTL3THYMchr142197182821971828GTSilentp.S99S1
METTL3HNSCchr142197931021979310CAMissense_Mutation1
METTL3LUSCchr142197930421979304CAMissense_Mutationp.R21M1
METTL3BLCAchr142196772821967728CTMissense_Mutationp.E454K1
METTL3KIRPchr142196791421967914ACMissense_Mutationp.L446R1
METTL3LGGchr142197199021971990GASilent1
METTL3UCECchr142197135021971350TCMissense_Mutationp.N230S1
METTL3BLCAchr142197146121971461GAMissense_Mutationp.S193L1
METTL3HNSCchr142196908721969087CTMissense_Mutation1
METTL3BLCAchr142196720621967206CTMissense_Mutationp.E532K1
METTL3OVchr142104120521041205AGMissense_Mutationp.I225T1
METTL3KIRPchr142196911521969115CGMissense_Mutationp.E352D1
METTL3BLCAchr142196772821967728CTMissense_Mutation1
METTL3CESCchr142197138321971383GAMissense_Mutation1
METTL3LGGchr142197150721971507GAMissense_Mutation1
METTL3HNSCchr142197133321971333CTMissense_Mutation1
METTL3BLCAchr142196773121967731CTMissense_Mutation1
METTL3KIRPchr142196920721969207GTMissense_Mutation1
METTL3BLCAchr142196768521967685CTMissense_Mutation1
METTL3CESCchr142197138321971383GANonsense_Mutationp.Q148*1
METTL3LGGchr142197154521971545CTMissense_Mutation1
METTL3BLCAchr142197166321971663GANonsense_Mutationp.Q126*1
METTL3HNSCchr142197190621971906ATSilent1
METTL3BLCAchr142197936521979365TCTranslation_Start_Site1
METTL3BLCAchr142196725721967257CAMissense_Mutationp.D515Y1

check buttonCopy number variation (CNV) of METTL3
* Click on the image to open the original image in a new window.
all structure

check buttonFusion gene breakpoints (product of the structural variants (SVs)) across METTL3
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


check button Fusion genes with this translation factor from FusionGDB2.0.
FusionGDB2 IDDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
87720LUSCTCGA-39-5019-01ADHRS1chr1424768163-METTL3chr1421970045-
87720UCECTCGA-AX-A3G7-01AHSPA8chr11122931834-METTL3chr1421967183-
87720STADTCGA-D7-8574-01AKTN1chr1456047072+METTL3chr1421972024-
60272N/ACA437449METTL3chr1421967264-BAP1chr352438507+
94937BLCATCGA-G2-A3IE-01AMETTL3chr1421971316-SALL2chr1421990378-
87720N/ABM148718NCKAP5chr2134276307+METTL3chr1421966285+
87720OVTCGA-13-0911PLXDC2chr1020466338+METTL3chr1421967946-
87720PRADTCGA-KK-A7B2SRP54chr1435488280+METTL3chr1421967946-
87728KIRCTCGA-CJ-5677-01ASTRN3chr1431398407-METTL3chr1421972024-
87728KIRCTCGA-CJ-5677-01ASTRN3chr1431404369-METTL3chr1421972024-


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Prognostic Analysis


check button Kaplan-Meier plots with logrank tests of overall survival (OS)
all structure
Cancer typeTranslation factorCoefficentHazard ratioWald test pvalLikelihool ratio pvalLogrank test pval# samples


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Translation factor and Gender


check button Differential gene expression between female and male. (Wilcoxon test, pval<0.05)
all structure
Cancer typeTranslation factorpvaladj.p
BLCAMETTL30.0319387415846730.89
LIHCMETTL30.03241477821863730.89

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Translation factor and Age


check button Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)
all structure
Cancer typeTranslation factorpvaladj.p
LUADMETTL30.005647802035919820.19
LUSCMETTL30.01234711698357210.4
KICHMETTL30.03841466239076791
LGGMETTL30.02943747712502390.91

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Related Drugs


check button Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)
UniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases


check button Diseases associated with this translation factor.
(DisGeNet 4.0)
Disease IDDisease Name# PubMedsDisease source