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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: PTAFR (NCBI Gene ID:5724)

Gene Summary

Gene Summary

Gene Information	Gene Name: PTAFR
	Gene ID: 5724
	Gene Symbol	PTAFR
	Gene ID	5724
	Gene Name	platelet activating factor receptor
	Synonyms	PAFR
	Cytomap	1p35.3
	Type of Gene	protein-coding
	Description	platelet-activating factor receptorPAF-R
	Modification date	20200313
	UniProtAcc	P25105

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0045727	Positive regulation of translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PTAFR	GO:0048015	phosphatidylinositol-mediated signaling	1657923

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
PTAFR	(355.7 - 733]

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Translation Studies in PubMed

We searched PubMed using 'PTAFR[title] AND translation [title] AND human.'

Gene	Title	PMID
PTAFR	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000539896	28503102	28503184	3UTR-3UTR

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
LUSC	PTAFR	-1.29122101254218	6.52423616562231e-08

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type

Gene

Coefficient

Pvalue

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with PTAFR (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
ACC	IUPHAR	PTAFR	CSF2RB	0.801085431	7.71E-19
ACC	IUPHAR	PTAFR	SLCO2B1	0.812904386	9.25E-20
BRCA	Cell metabolism gene	PTAFR	PIK3CG	0.823802396	4.85E-302
BRCA	IUPHAR	PTAFR	TLR8	0.821024555	2.60E-298
BRCA	IUPHAR	PTAFR	PIK3CG	0.823802396	4.85E-302
BRCA	IUPHAR	PTAFR	CYBB	0.829233736	0.00E+00
COAD	Cell metabolism gene	PTAFR	PIK3R5	0.816479267	5.35E-80
COAD	CGC	PTAFR	PTPRC	0.801483813	5.31E-75
COAD	CGC	PTAFR	CSF1R	0.807984604	4.10E-77
COAD	IUPHAR	PTAFR	PTPRC	0.801483813	5.31E-75
COAD	IUPHAR	PTAFR	CMKLR1	0.801871515	3.99E-75
COAD	IUPHAR	PTAFR	CLEC7A	0.80191387	3.87E-75
COAD	IUPHAR	PTAFR	TLR1	0.802501441	2.51E-75
COAD	IUPHAR	PTAFR	LAIR1	0.80403853	8.02E-76
COAD	IUPHAR	PTAFR	HCK	0.806275912	1.50E-76
COAD	IUPHAR	PTAFR	CSF1R	0.807984604	4.10E-77
COAD	IUPHAR	PTAFR	CSF2RB	0.810179472	7.61E-78
COAD	IUPHAR	PTAFR	IL10RA	0.810616761	5.43E-78
COAD	IUPHAR	PTAFR	FPR3	0.811626272	2.48E-78
COAD	IUPHAR	PTAFR	TLR8	0.813800358	4.51E-79
COAD	IUPHAR	PTAFR	PIK3R5	0.816479267	5.35E-80
COAD	IUPHAR	PTAFR	CD86	0.818767161	8.43E-81
COAD	IUPHAR	PTAFR	ITGB2	0.819525058	4.54E-81
COAD	IUPHAR	PTAFR	LILRB1	0.820536413	1.98E-81
COAD	IUPHAR	PTAFR	C3AR1	0.82213466	5.29E-82
COAD	IUPHAR	PTAFR	CYBB	0.832773144	5.65E-86
COAD	Kinase	PTAFR	HCK	0.806275912	1.50E-76
COAD	Kinase	PTAFR	CSF1R	0.807984604	4.10E-77
COAD	TSG	PTAFR	PTPRC	0.801483813	5.31E-75
DLBC	Cell metabolism gene	PTAFR	PPAP2B	0.822829636	7.22E-13
GBM	Cell metabolism gene	PTAFR	PLCG2	0.837299059	1.93E-46
GBM	Cell metabolism gene	PTAFR	PIK3CG	0.903691533	1.61E-64
GBM	CGC	PTAFR	CSF1R	0.821961976	2.04E-43
GBM	CGC	PTAFR	VAV1	0.840888718	3.41E-47
GBM	CGC	PTAFR	SYK	0.842562148	1.49E-47
GBM	CGC	PTAFR	IKZF1	0.85247574	9.26E-50
GBM	CGC	PTAFR	PTPRC	0.853568008	5.17E-50
GBM	Epifactor	PTAFR	IKZF1	0.85247574	9.26E-50
GBM	IUPHAR	PTAFR	CD4	0.802386847	5.91E-40
GBM	IUPHAR	PTAFR	ITGAL	0.803203439	4.32E-40
GBM	IUPHAR	PTAFR	ATP8B4	0.815661952	2.94E-42
GBM	IUPHAR	PTAFR	SLCO2B1	0.816266431	2.29E-42
GBM	IUPHAR	PTAFR	CSF2RB	0.817014892	1.67E-42
GBM	IUPHAR	PTAFR	CSF1R	0.821961976	2.04E-43
GBM	IUPHAR	PTAFR	LILRB1	0.826521555	2.76E-44
GBM	IUPHAR	PTAFR	NLRP3	0.826900004	2.34E-44
GBM	IUPHAR	PTAFR	TLR6	0.833370067	1.23E-45
GBM	IUPHAR	PTAFR	PLCG2	0.837299059	1.93E-46
GBM	IUPHAR	PTAFR	LPAR5	0.838087928	1.32E-46
GBM	IUPHAR	PTAFR	TLR7	0.842093609	1.88E-47
GBM	IUPHAR	PTAFR	SYK	0.842562148	1.49E-47
GBM	IUPHAR	PTAFR	PTPRC	0.853568008	5.17E-50
GBM	IUPHAR	PTAFR	CYBB	0.853740392	4.72E-50
GBM	IUPHAR	PTAFR	PIK3CG	0.903691533	1.61E-64
GBM	Kinase	PTAFR	CSF1R	0.821961976	2.04E-43
GBM	Kinase	PTAFR	SYK	0.842562148	1.49E-47
GBM	TF	PTAFR	IRF8	0.807485018	8.10E-41
GBM	TF	PTAFR	IKZF1	0.85247574	9.26E-50
GBM	TSG	PTAFR	CD4	0.802386847	5.91E-40
GBM	TSG	PTAFR	IRF8	0.807485018	8.10E-41
GBM	TSG	PTAFR	SYK	0.842562148	1.49E-47
GBM	TSG	PTAFR	IKZF1	0.85247574	9.26E-50
GBM	TSG	PTAFR	PTPRC	0.853568008	5.17E-50
LAML	Cell metabolism gene	PTAFR	CDA	0.812909993	5.31E-42
LAML	Cell metabolism gene	PTAFR	HK3	0.838032217	7.39E-47
LAML	IUPHAR	PTAFR	FCER1G	0.805691539	9.69E-41
LAML	IUPHAR	PTAFR	ITGAM	0.810372221	1.49E-41
LAML	IUPHAR	PTAFR	CCR1	0.812525707	6.22E-42
LAML	IUPHAR	PTAFR	CDA	0.812909993	5.31E-42
LGG	Cell metabolism gene	PTAFR	ALOX5	0.807987816	2.14E-123
LGG	Cell metabolism gene	PTAFR	PIK3CG	0.916240575	6.70E-212
LGG	CGC	PTAFR	BTK	0.813878416	1.34E-126
LGG	CGC	PTAFR	LCP1	0.821228463	9.30E-131
LGG	CGC	PTAFR	VAV1	0.838135255	4.25E-141
LGG	CGC	PTAFR	CSF1R	0.849735307	6.58E-149
LGG	CGC	PTAFR	IKZF1	0.857347457	2.11E-154
LGG	CGC	PTAFR	PTPRC	0.880520488	2.57E-173
LGG	CGC	PTAFR	SYK	0.884815362	2.97E-177
LGG	Epifactor	PTAFR	IKZF1	0.857347457	2.11E-154
LGG	IUPHAR	PTAFR	P2RY13	0.800024487	3.08E-119
LGG	IUPHAR	PTAFR	MNDA	0.801297102	6.86E-120
LGG	IUPHAR	PTAFR	AOAH	0.802198428	2.36E-120
LGG	IUPHAR	PTAFR	HCK	0.802950699	9.61E-121
LGG	IUPHAR	PTAFR	C3AR1	0.804440158	1.61E-121
LGG	IUPHAR	PTAFR	SLCO2B1	0.80599951	2.44E-122
LGG	IUPHAR	PTAFR	ALOX5	0.807987816	2.14E-123
LGG	IUPHAR	PTAFR	BTK	0.813878416	1.34E-126
LGG	IUPHAR	PTAFR	CX3CR1	0.818039016	6.26E-129
LGG	IUPHAR	PTAFR	IL12RB1	0.819682545	7.23E-130
LGG	IUPHAR	PTAFR	HAVCR2	0.822276206	2.29E-131
LGG	IUPHAR	PTAFR	ITGB2	0.82595335	1.56E-133
LGG	IUPHAR	PTAFR	GPR34	0.826728515	5.35E-134
LGG	IUPHAR	PTAFR	CD86	0.830123248	4.69E-136
LGG	IUPHAR	PTAFR	ADAM28	0.835876504	1.20E-139
LGG	IUPHAR	PTAFR	ATP8B4	0.837896079	6.07E-141
LGG	IUPHAR	PTAFR	TLR5	0.841675033	2.05E-143
LGG	IUPHAR	PTAFR	CCR1	0.841935805	1.38E-143
LGG	IUPHAR	PTAFR	CSF1R	0.849735307	6.58E-149
LGG	IUPHAR	PTAFR	LPAR5	0.851462384	3.97E-150
LGG	IUPHAR	PTAFR	ITGAM	0.860517228	8.75E-157
LGG	IUPHAR	PTAFR	LILRB1	0.863271685	6.66E-159
LGG	IUPHAR	PTAFR	CSF2RB	0.865413468	1.39E-160
LGG	IUPHAR	PTAFR	PTPRC	0.880520488	2.57E-173
LGG	IUPHAR	PTAFR	TLR1	0.883931524	1.97E-176
LGG	IUPHAR	PTAFR	SYK	0.884815362	2.97E-177
LGG	IUPHAR	PTAFR	CYBB	0.893754561	5.60E-186
LGG	IUPHAR	PTAFR	TLR6	0.907359185	7.12E-201
LGG	IUPHAR	PTAFR	PIK3CG	0.916240575	6.70E-212
LGG	IUPHAR	PTAFR	TLR7	0.919191008	7.75E-216
LGG	Kinase	PTAFR	HCK	0.802950699	9.61E-121
LGG	Kinase	PTAFR	BTK	0.813878416	1.34E-126
LGG	Kinase	PTAFR	CSF1R	0.849735307	6.58E-149
LGG	Kinase	PTAFR	SYK	0.884815362	2.97E-177
LGG	TF	PTAFR	TFEC	0.836879176	2.74E-140
LGG	TF	PTAFR	IRF8	0.839805085	3.49E-142
LGG	TF	PTAFR	IKZF1	0.857347457	2.11E-154
LGG	TSG	PTAFR	LAT2	0.807391286	4.46E-123
LGG	TSG	PTAFR	BLNK	0.810936018	5.52E-125
LGG	TSG	PTAFR	BTK	0.813878416	1.34E-126
LGG	TSG	PTAFR	ARL11	0.827596282	1.61E-134
LGG	TSG	PTAFR	IRF8	0.839805085	3.49E-142
LGG	TSG	PTAFR	IKZF1	0.857347457	2.11E-154
LGG	TSG	PTAFR	PTPRC	0.880520488	2.57E-173
LGG	TSG	PTAFR	SYK	0.884815362	2.97E-177
LUAD	IUPHAR	PTAFR	FPR3	0.804982074	2.99E-132
LUAD	IUPHAR	PTAFR	SLCO2B1	0.814011099	1.53E-137
LUAD	IUPHAR	PTAFR	CYBB	0.828009749	2.41E-146
MESO	Cell metabolism gene	PTAFR	PIK3CG	0.848373426	3.36E-25
MESO	IUPHAR	PTAFR	GPR141	0.817503883	4.49E-22
MESO	IUPHAR	PTAFR	CYBB	0.828315207	4.25E-23
MESO	IUPHAR	PTAFR	PIK3CG	0.848373426	3.36E-25
MESO	TF	PTAFR	TFEC	0.834037833	1.14E-23
PRAD	Cell metabolism gene	PTAFR	PIK3CG	0.891847979	5.95E-191
PRAD	CGC	PTAFR	PTPRC	0.841863887	6.64E-149
PRAD	IUPHAR	PTAFR	P2RX7	0.805078762	2.13E-126
PRAD	IUPHAR	PTAFR	TLR6	0.805079282	2.12E-126
PRAD	IUPHAR	PTAFR	TLR8	0.813025532	7.81E-131
PRAD	IUPHAR	PTAFR	TLR1	0.820510869	3.29E-135
PRAD	IUPHAR	PTAFR	ITGA4	0.831740603	3.59E-142
PRAD	IUPHAR	PTAFR	PTPRC	0.841863887	6.64E-149
PRAD	IUPHAR	PTAFR	CYBB	0.843050815	1.00E-149
PRAD	IUPHAR	PTAFR	PIK3CG	0.891847979	5.95E-191
PRAD	TSG	PTAFR	PTPRC	0.841863887	6.64E-149
PRAD	TSG	PTAFR	PLXNC1	0.85866004	3.40E-161
READ	IUPHAR	PTAFR	NLRP3	0.817032649	2.24E-26
SKCM	Cell metabolism gene	PTAFR	ALOX5	0.815823925	2.45E-114
SKCM	Cell metabolism gene	PTAFR	PIK3R5	0.816166993	1.65E-114
SKCM	CGC	PTAFR	IKZF1	0.811320418	4.10E-112
SKCM	CGC	PTAFR	VAV1	0.840415746	1.16E-127
SKCM	CGC	PTAFR	CSF1R	0.841161913	4.23E-128
SKCM	Epifactor	PTAFR	IKZF1	0.811320418	4.10E-112
SKCM	IUPHAR	PTAFR	CCR5	0.804907628	4.77E-109
SKCM	IUPHAR	PTAFR	SLC7A7	0.806069663	1.35E-109
SKCM	IUPHAR	PTAFR	C3AR1	0.809227888	4.23E-111
SKCM	IUPHAR	PTAFR	TNFRSF1B	0.809736229	2.41E-111
SKCM	IUPHAR	PTAFR	TLR7	0.811628427	2.90E-112
SKCM	IUPHAR	PTAFR	CD4	0.812936509	6.64E-113
SKCM	IUPHAR	PTAFR	ALOX5	0.815823925	2.45E-114
SKCM	IUPHAR	PTAFR	PIK3R5	0.816166993	1.65E-114
SKCM	IUPHAR	PTAFR	INPP5D	0.820338707	1.25E-116
SKCM	IUPHAR	PTAFR	CCRL2	0.826019014	1.32E-119
SKCM	IUPHAR	PTAFR	HAVCR2	0.826365032	8.63E-120
SKCM	IUPHAR	PTAFR	CD86	0.829036377	3.13E-121
SKCM	IUPHAR	PTAFR	AOAH	0.837221456	8.33E-126
SKCM	IUPHAR	PTAFR	CSF1R	0.841161913	4.23E-128
SKCM	IUPHAR	PTAFR	IL10RA	0.842801013	4.50E-129
SKCM	IUPHAR	PTAFR	LAIR1	0.84415364	6.96E-130
SKCM	IUPHAR	PTAFR	HCK	0.847274123	8.73E-132
SKCM	IUPHAR	PTAFR	CSF2RB	0.847664609	5.01E-132
SKCM	IUPHAR	PTAFR	CYBB	0.849438165	3.96E-133
SKCM	IUPHAR	PTAFR	SLCO2B1	0.852813435	2.88E-135
SKCM	IUPHAR	PTAFR	CMKLR1	0.854734461	1.65E-136
SKCM	IUPHAR	PTAFR	TLR8	0.861025678	1.06E-140
SKCM	IUPHAR	PTAFR	FPR3	0.862100326	1.93E-141
SKCM	IUPHAR	PTAFR	ITGB2	0.862631001	8.32E-142
SKCM	Kinase	PTAFR	CSF1R	0.841161913	4.23E-128
SKCM	Kinase	PTAFR	HCK	0.847274123	8.73E-132
SKCM	TF	PTAFR	IRF8	0.80901786	5.33E-111
SKCM	TF	PTAFR	IKZF1	0.811320418	4.10E-112
SKCM	TSG	PTAFR	DOK2	0.804646575	6.32E-109
SKCM	TSG	PTAFR	IRF8	0.80901786	5.33E-111
SKCM	TSG	PTAFR	ARL11	0.810399374	1.15E-111
SKCM	TSG	PTAFR	IKZF1	0.811320418	4.10E-112
SKCM	TSG	PTAFR	CD4	0.812936509	6.64E-113
TGCT	CGC	PTAFR	CD274	0.808610138	2.64E-37
TGCT	IUPHAR	PTAFR	FPR3	0.801912079	2.83E-36
TGCT	IUPHAR	PTAFR	CYBB	0.840479451	7.91E-43
TGCT	IUPHAR	PTAFR	P2RX7	0.851054345	6.18E-45
TGCT	IUPHAR	PTAFR	TLR8	0.853799249	1.65E-45
THYM	Cell metabolism gene	PTAFR	PRKAR2A	0.801131794	1.59E-28
THYM	CGC	PTAFR	NFATC2	0.843582125	3.39E-34
THYM	IUPHAR	PTAFR	PRKAR2A	0.801131794	1.59E-28
THYM	IUPHAR	PTAFR	SLC8A1	0.803898059	7.52E-29
THYM	TF	PTAFR	NFATC2	0.843582125	3.39E-34
THYM	TSG	PTAFR	PLXNC1	0.831731778	1.87E-32
THYM	TSG	PTAFR	NFATC2	0.843582125	3.39E-34
UCS	Cell metabolism gene	PTAFR	PRKAR2A	0.801131794	1.59E-28
UCS	CGC	PTAFR	NFATC2	0.843582125	3.39E-34
UCS	IUPHAR	PTAFR	PRKAR2A	0.801131794	1.59E-28
UCS	IUPHAR	PTAFR	SLC8A1	0.803898059	7.52E-29
UCS	TF	PTAFR	NFATC2	0.843582125	3.39E-34
UCS	TSG	PTAFR	PLXNC1	0.831731778	1.87E-32
UCS	TSG	PTAFR	NFATC2	0.843582125	3.39E-34
UVM	CGC	PTAFR	VAV1	0.821047872	1.11E-20
UVM	CGC	PTAFR	CIITA	0.840917627	1.69E-22
UVM	IUPHAR	PTAFR	CCR1	0.802323443	3.69E-19
UVM	IUPHAR	PTAFR	LAIR1	0.806623437	1.71E-19
UVM	IUPHAR	PTAFR	HAVCR2	0.812900964	5.36E-20
UVM	IUPHAR	PTAFR	TLR7	0.819832705	1.41E-20
UVM	IUPHAR	PTAFR	FPR3	0.83310863	9.35E-22
UVM	IUPHAR	PTAFR	CIITA	0.840917627	1.69E-22
UVM	IUPHAR	PTAFR	CYBB	0.844110469	8.16E-23
UVM	IUPHAR	PTAFR	C3AR1	0.86664234	2.90E-25
UVM	IUPHAR	PTAFR	SLCO2B1	0.88080558	4.80E-27

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
THCA	PTAFR	CCR1	-1.45292123581675	0.000153517118172136
BRCA	PTAFR	CCR5	1.77963575207894	0.00109837276059838
LIHC	PTAFR	CCR5	1.93788004327333	0.00559718505377969
LUSC	PTAFR	IL10	-1.45553017786508	0.01064107909388
THCA	PTAFR	FPR1	-1.18121264779159	0.0120833079959075
BRCA	PTAFR	FPR1	-1.80190386169973	0.0149738572566545
KIRC	PTAFR	ARRB1	-1.23882769931785	0.0154589087544626
KIRP	PTAFR	TNFRSF1B	-8.24285768478505	0.0453950124792755
UCEC	PTAFR	CCR2	3.08796157207097	0.046875
KICH	PTAFR	CCR2	2.28741343083278	0.0482624173164368
KIRC	PTAFR	CCR2	2.61854404056411	1.86484053395e-10
LUAD	PTAFR	FPR1	-1.03066417653715	2.50960797565542e-06
LUAD	PTAFR	ARRB1	-1.30659580538604	2.52416671917541e-10
LUSC	PTAFR	STAT3	-1.0616935152134	2.622390634108e-05
LUSC	PTAFR	CCR1	-2.46289921134003	2.7232742434021e-09
LUSC	PTAFR	FPR1	-2.15388184332568	3.23227619897643e-09
KIRC	PTAFR	STAT3	-1.71331361645034	3.24635122520647e-05
PRAD	PTAFR	IL1RN	1.00655398666853	3.35098773659188e-05
COAD	PTAFR	ARRB1	-1.19993983055663	4.17232513427735e-07
LIHC	PTAFR	IL1RN	-1.17025196619118	4.1802575188172e-08
LUSC	PTAFR	CCR5	-1.96406075403609	4.4621975457841e-05
HNSC	PTAFR	ARRB1	2.25877456077734	5.40012479177677e-10
LUAD	PTAFR	TNFRSF1B	-1.06956730695987	5.48906105617824e-05
LIHC	PTAFR	TNFRSF1B	-2.07609287635481	6.54165600156036e-06
LUSC	PTAFR	CCR2	-2.04872284613108	7.11803396854217e-09
BRCA	PTAFR	ARRB1	-1.83334882828542	8.96524795928413e-27

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with PTAFR

ARRB2, PTK2, JAK2, TYK2, ARRB1, CLTC, CALM1, GTPBP3, GORAB, SPATA24, HEXIM1, MBP, PRNP, GRIN1, IFITM3, MFSD3, PLLP, RHBDD2, SERINC5, TMX2, TMEM120A, PPM1J, SCAMP2, ATP13A1, RABL3, C6orf211, TMEM246, GOLGA5, RABIF, KIAA2013, YIPF3, ATE1, TM9SF4, GPRC5C, EIF2B5, EIF2B1, ATP12A, ATP1A3, TM9SF1, TBL2, TMEM259, EIF2B4, EIF2B2, EIF2B3, ERGIC2, PTP4A1, SLC7A1, EPHX1,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
PTAFR	chr1	28476713	C	T	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
PTAFR	LUAD	chr1	28476668	28476668	C	A	Missense_Mutation	p.D289Y	7
PTAFR	LUAD	chr1	28477276	28477276	G	T	Missense_Mutation	p.P86H	5
PTAFR	KIRP	chr1	28477260	28477260	G	A	Silent	p.N91N	4
PTAFR	BLCA	chr1	28477482	28477482	G	C	Silent	p.L17L	4
PTAFR	BLCA	chr1	28476798	28476798	G	A	Silent	p.F245F	3
PTAFR	CESC	chr1	28476822	28476822	G	A	Silent		3
PTAFR	LUAD	chr1	28477077	28477077	G	A	Silent	p.F152F	3
PTAFR	SKCM	chr1	28477113	28477113	G	A	Silent	p.V140V	3
PTAFR	SKCM	chr1	28477476	28477476	C	T	Silent	p.P19P	2
PTAFR	UCEC	chr1	28476507	28476507	A	C	Missense_Mutation	p.N342K	2
PTAFR	SARC	chr1	28503185	28503185	C	G	Splice_Site		2
PTAFR	UCEC	chr1	28476869	28476869	G	A	Missense_Mutation	p.R222C	2
PTAFR	UCEC	chr1	28477017	28477017	G	A	Silent	p.R172	2
PTAFR	SKCM	chr1	28477362	28477362	C	T	Silent	p.V57V	2
PTAFR	BLCA	chr1	28477482	28477482	G	C	Silent		2
PTAFR	UCEC	chr1	28477281	28477281	T	C	Missense_Mutation	p.I84M	2
PTAFR	SKCM	chr1	28476731	28476731	G	A	Missense_Mutation	p.H268Y	2
PTAFR	UCEC	chr1	28477310	28477310	C	T	Missense_Mutation	p.V75I	2
PTAFR	SKCM	chr1	28476528	28476528	G	A	Silent	p.I335I	2
PTAFR	LUAD	chr1	28476723	28476723	G	-	Frame_Shift_Del	p.A270fs	2
PTAFR	LGG	chr1	28477144	28477144	G	A	Missense_Mutation	p.T130I	2
PTAFR	STAD	chr1	28477206	28477206	G	A	Silent		2
PTAFR	SKCM	chr1	28477119	28477119	G	A	Silent	p.S138S	2
PTAFR	LGG	chr1	28477144	28477144	G	A	Missense_Mutation		2
PTAFR	STAD	chr1	28477206	28477206	G	A	Silent	p.G109G	2
PTAFR	SKCM	chr1	28476822	28476822	G	A	Silent	p.V237V	2
PTAFR	LIHC	chr1	28477275	28477275	G	-	Frame_Shift_Del	p.P86fs	2
PTAFR	STAD	chr1	28476598	28476598	C	T	Missense_Mutation	p.R312H	2
PTAFR	BLCA	chr1	28476921	28476921	G	T	Missense_Mutation	p.F204L	2
PTAFR	GBM	chr1	28477001	28477001	C	T	Missense_Mutation	p.E178K	2
PTAFR	SKCM	chr1	28477170	28477170	C	T	Silent	p.R121R	2
PTAFR	STAD	chr1	28476590	28476590	G	A	Missense_Mutation	p.R315W	2
PTAFR	BLCA	chr1	28477356	28477356	G	A	Silent	p.L59L	2
PTAFR	PAAD	chr1	28477465	28477465	C	A	Missense_Mutation		2
PTAFR	SKCM	chr1	28477168	28477168	G	A	Missense_Mutation	p.P122L	2
PTAFR	STAD	chr1	28476914	28476914	G	T	Missense_Mutation	p.L207M	2
PTAFR	PRAD	chr1	28476664	28476664	G	T	Missense_Mutation	p.P290H	1
PTAFR	GBM	chr1	28477136	28477136	G	A	Missense_Mutation		1
PTAFR	BLCA	chr1	28477335	28477335	G	A	Silent	p.F66F	1
PTAFR	GBM	chr1	28477205	28477205	C	T	Missense_Mutation		1
PTAFR	SKCM	chr1	28476903	28476903	G	A	Silent	p.I210I	1
PTAFR	STAD	chr1	28477529	28477529	C	T	Missense_Mutation	p.E2K	1
PTAFR	LUAD	chr1	28476674	28476674	C	G	Missense_Mutation	p.V287L	1
PTAFR	SARC	chr1	28503185	28503185	C	G	Splice_Site	e1-1	1
PTAFR	GBM	chr1	28477001	28477001	C	T	Missense_Mutation		1
PTAFR	SKCM	chr1	28477268	28477268	G	A	Silent	p.L89L	1
PTAFR	STAD	chr1	28477221	28477221	A	G	Silent	p.S104S	1
PTAFR	BLCA	chr1	28476921	28476921	G	T	Missense_Mutation		1
PTAFR	LUAD	chr1	28477108	28477108	C	A	Missense_Mutation	p.W142L	1
PTAFR	CESC	chr1	28476617	28476617	C	A	Nonsense_Mutation		1
PTAFR	KIRC	chr1	28477382	28477382	C	A	Nonsense_Mutation	p.E51*	1
PTAFR	SKCM	chr1	28477239	28477239	G	A	Silent	p.F98F	1
PTAFR	STAD	chr1	28476770	28476770	A	G	Missense_Mutation	p.W255R	1
PTAFR	CESC	chr1	28476617	28476617	C	A	Nonsense_Mutation	p.E306*	1
PTAFR	SKCM	chr1	28477346	28477346	C	T	Missense_Mutation	p.D63N	1
PTAFR	STAD	chr1	28477427	28477427	C	T	Missense_Mutation		1
PTAFR	BLCA	chr1	28477356	28477356	G	A	Silent		1
PTAFR	LUAD	chr1	28476541	28476541	G	A	Missense_Mutation	p.P331L	1
PTAFR	CESC	chr1	28476822	28476822	G	A	Silent	p.V237	1
PTAFR	KIRP	chr1	28476939	28476939	G	T	Silent		1
PTAFR	SKCM	chr1	28477200	28477200	G	A	Silent	p.I111I	1
PTAFR	THYM	chr1	28477189	28477189	C	T	Missense_Mutation		1
PTAFR	BLCA	chr1	28476798	28476798	G	A	Silent		1
PTAFR	DLBC	chr1	28476520	28476520	T	C	Missense_Mutation	p.N338S	1
PTAFR	THYM	chr1	28477189	28477189	C	T	Missense_Mutation	p.R115H	1
PTAFR	BLCA	chr1	28477335	28477335	G	A	Silent		1
PTAFR	LUSC	chr1	28476843	28476843	C	T	Silent	p.A230A	1
PTAFR	ESCA	chr1	28476632	28476632	G	T	Missense_Mutation		1
PTAFR	THYM	chr1	28476574	28476574	G	A	Missense_Mutation	p.A320V	1
PTAFR	LUSC	chr1	28477434	28477434	A	T	Missense_Mutation	p.N33K	1
PTAFR	ESCA	chr1	28476632	28476632	G	T	Missense_Mutation	p.R301S	1
PTAFR	UCEC	chr1	28476850	28476850	C	T	Missense_Mutation	p.R228H	1
PTAFR	LUSC	chr1	28476668	28476668	C	G	Missense_Mutation	p.D289H	1
PTAFR	LIHC	chr1	28477243	28477243	A	-	Frame_Shift_Del	p.F98fs	1
PTAFR	UCEC	chr1	28476617	28476617	C	T	Missense_Mutation	p.E306K	1
PTAFR	GBM	chr1	28477494	28477494	G	A	Silent	p.F13F	1
PTAFR	UCEC	chr1	28476658	28476658	A	-	Frame_Shift_Del	p.I292fs	1

Copy number variation (CNV) of PTAFR
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across PTAFR
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
33574	LUAD	TCGA-05-4398-01A	EXOC4	chr7	133314894	+	PTAFR	chr1	28477570	-
33576	OV	TCGA-29-1697	GNAI3	chr1	110091460	+	PTAFR	chr1	28477570	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
SARC	PTAFR	0.0269952793202647	0.76
CHOL	PTAFR	0.0328089279612284	0.89
KIRC	PTAFR	0.0373188696325139	0.97

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	PTAFR	0.0316556121832272	0.95
LGG	PTAFR	0.000591117278419604	0.02
PRAD	PTAFR	0.0199935932041152	0.64
SKCM	PTAFR	0.037039199989318	1
THYM	PTAFR	0.0214974800452189	0.67

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
P25105	DB02261	Platelet Activating Factor		Small molecule	Experimental
P25105	DB09166	Etizolam	Antagonist	Small molecule	Experimental
P25105	DB11614	Rupatadine	Antagonist	Small molecule	Approved
P25105	DB02261	Platelet Activating Factor
P25105	DB09166	Etizolam	Antagonist
P25105	DB11614	Rupatadine	Antagonist

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0023893	Liver Cirrhosis, Experimental	1	CTD_human
C0032460	Polycystic Ovary Syndrome	1	CTD_human
C1136382	Sclerocystic Ovaries	1	CTD_human