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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RGS2 (NCBI Gene ID:5997)

Gene Summary

Gene Summary

Gene Information	Gene Name: RGS2
	Gene ID: 5997
	Gene Symbol	RGS2
	Gene ID	5997
	Gene Name	regulator of G protein signaling 2
	Synonyms	G0S8
	Cytomap	1q31.2
	Type of Gene	protein-coding
	Description	regulator of G-protein signaling 2G0 to G1 switch regulatory 8, 24kDG0/G1 switch regulatory protein 8cell growth-inhibiting gene 31 proteincell growth-inhibiting protein 31regulator of G-protein signaling 2, 24kDa
	Modification date	20200313
	UniProtAcc	P41220

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0017148	Negative regulation of translation
GO:0006417	Regulation of translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
RGS2	(355.7 - 733]

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Translation Studies in PubMed

We searched PubMed using 'RGS2[title] AND translation [title] AND human.'

Gene	Title	PMID
RGS2	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000235382	192780110	192780277	Frame-shift

Exon skipping position in the amino acid sequence.

ENST

Exon skip start (DNA)

Exon Skip end (DNA)

Len(transcript seq)

Exon skip start (mRNA)

Exon Skip end (mRNA)

Len(amino acid seq)

Exon skip start (AA)

Exon Skip end (AA)

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc

Exon skip start (AA)

Exon Skip end (AA)

Function feature start (AA)

Function feature end (AA)

Functional feature type

Functional feature desc.

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
LUAD	RGS2	-1.01495514480034	0.00011911183667634
LUSC	RGS2	-2.9333070888024	2.37905817526319e-08
STAD	RGS2	-3.43175749315655	2.98023223876953e-07
BLCA	RGS2	-3.42279821999535	3.814697265625e-06

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
LUAD	RGS2	1	2	0.0362071239455933	0.184511841097987	0.214687132352941	-0.402882319793384	-0.524305131280206

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
KIRC	RGS2	2	1	0.000604204888714739	0.225527851473923	0.190905555555556	0.0250243971642034	0.370802401699432

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
THCA	RGS2	0.244068272	0.010162892

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RGS2 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
COAD	Cell metabolism gene	RGS2	CAV1	0.800943375	7.89E-75
COAD	TSG	RGS2	CAV1	0.800943375	7.89E-75
LAML	CGC	RGS2	SGK1	0.818099884	6.08E-43
LAML	IUPHAR	RGS2	SGK1	0.818099884	6.08E-43
LAML	Kinase	RGS2	SGK1	0.818099884	6.08E-43
MESO	IUPHAR	RGS2	NR4A1	0.834327575	1.07E-23
MESO	TF	RGS2	EGR1	0.800252488	1.42E-20
MESO	TF	RGS2	NR4A1	0.834327575	1.07E-23
MESO	TSG	RGS2	EGR1	0.800252488	1.42E-20
MESO	TSG	RGS2	NR4A1	0.834327575	1.07E-23
READ	Cell metabolism gene	RGS2	LYVE1	0.804393453	4.94E-25
READ	Cell metabolism gene	RGS2	PDE2A	0.807323492	2.46E-25
READ	Cell metabolism gene	RGS2	CAV1	0.810895293	1.04E-25
READ	CGC	RGS2	ZEB1	0.805998037	3.38E-25
READ	IUPHAR	RGS2	PDE2A	0.807323492	2.46E-25
READ	IUPHAR	RGS2	MYLK	0.810821099	1.05E-25
READ	IUPHAR	RGS2	SLC9A9	0.816088693	2.84E-26
READ	Kinase	RGS2	MYLK	0.810821099	1.05E-25
READ	TF	RGS2	ZEB1	0.805998037	3.38E-25
READ	TSG	RGS2	SFRP1	0.80509446	4.19E-25
READ	TSG	RGS2	SPARCL1	0.80681062	2.78E-25
READ	TSG	RGS2	CAV1	0.810895293	1.04E-25
READ	TSG	RGS2	FHL1	0.823622413	4.04E-27
READ	TSG	RGS2	TCEAL7	0.82817098	1.19E-27

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
LUAD	RGS2	RGS19	-1.08992318365008	0.000242671052720231
LIHC	RGS2	RGS1	1.96744589313663	0.000341801925418751
KIRP	RGS2	RGS16	3.4080442826603	0.000397900585085154
KICH	RGS2	RGS16	3.66925339991675	0.000556409358978271
STAD	RGS2	GNAQ	-1.7182645709596	0.00166679499670863
BLCA	RGS2	GNAI3	2.09323749260854	0.0016937255859375
BLCA	RGS2	RGS1	-4.36109865492806	0.0033416748046875
CHOL	RGS2	PPP1R9B	-4.64716927531298	0.00390625
ESCA	RGS2	GNAQ	-1.30042285116727	0.0048828125
ESCA	RGS2	RGS19	-2.6325905732562	0.0068359375
LUAD	RGS2	RGS1	1.06885635348342	0.0160458836949277
CHOL	RGS2	RGS19	-3.73541701297276	0.01953125
THCA	RGS2	RGS4	-7.36913880511369	0.0202867028625357
KICH	RGS2	RGS1	-1.82652199427335	0.0274794101715088
UCEC	RGS2	RGS19	-1.31083072142278	0.03125
LIHC	RGS2	RGS16	1.19768754091559	0.0345094573036436
HNSC	RGS2	GNAQ	1.39363399916288	0.0448960527075997
UCEC	RGS2	RGS18	1.54987247399523	0.046875
KIRP	RGS2	RGS19	-3.34703020454911	1.17812305688858e-07
BRCA	RGS2	GNAQ	-1.42809180012775	1.24221841523555e-11
LUSC	RGS2	RGS17	-7.14546305462064	1.41664343267922e-06
BRCA	RGS2	PPP1R9B	-1.40557748622853	2.26357768285155e-09
THCA	RGS2	RGS16	-1.02782560951198	2.3500379803691e-10
LUSC	RGS2	RGS16	-1.4606082759988	3.56628110751149e-06
KICH	RGS2	GNAI3	3.29687821445056	4.17232513427734e-07
LUAD	RGS2	GNAQ	-3.47177253915815	4.43580332236554e-11
LUSC	RGS2	RGS19	-1.74050902473622	5.18010026419767e-07
BRCA	RGS2	RGS16	3.09760694053769	5.88254668472608e-08
BRCA	RGS2	RGS19	-3.18533225274613	6.50198169869283e-18
KIRC	RGS2	RGS19	-4.33331948095562	6.68277496381108e-13
LUAD	RGS2	RGS18	-1.0658534863599	7.6383730645682e-06
THCA	RGS2	RGS19	-1.75253215332683	9.09205950376733e-05

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RGS2

NINL, IBTK, EIF3E, PRKG1, GNA15, GNAQ, ADCY5, WDR74, LRFN1, NIPSNAP1, VPS29, ARFGAP1, DYNLL1, PARK2, PRKCSH, DDR1, HSPA8, GIT1, GNAI3, COPB2, PRKCA, PRKCB, PRKCG, GDE1, GNAS, TSPAN15, CTSB, RAB2A, LIG1, BBS10, KIAA1377, REEP5, ZYX, COMT, EIF3L, ZBTB48, IER3IP1, ZNF579, MON1A, HAUS5, DUSP21, RABAC1, UBC, CHD3, RIN3, XRCC6, TUBB2B, CRMP1, METTL18, KLK8, RAP1B, CLTA, FZD5, ADRB2, MTUS2, FBXO44, DDB1, MIPOL1, PTPN13, STXBP4, METAP2, STRIP1, KBTBD7, STK26, SERPINA10, TAF2, EGFR, CUL4B, MARCH6, CIAO1, LOC102724334, NISCH, MB, EPHX1, FAM49B,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
RGS2	chr1	192778269	G	A	single_nucleotide_variant	Uncertain_significance	not_specified	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RGS2	chr1	192779333	C	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RGS2	chr1	192779562	G	T	single_nucleotide_variant	Likely_pathogenic	not_provided	SO:0001575\|splice_donor_variant	SO:0001575\|splice_donor_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RGS2	PAAD	chr1	192779364	192779364	C	T	Missense_Mutation	p.T60I	3
RGS2	LIHC	chr1	192779369	192779369	A	-	Frame_Shift_Del	p.K63fs	2
RGS2	BLCA	chr1	192780193	192780193	C	G	Missense_Mutation	p.F119L	2
RGS2	READ	chr1	192780688	192780688	A	-	Nonsense_Mutation	p.C199X	2
RGS2	ESCA	chr1	192779527	192779527	G	T	Missense_Mutation	p.W80C	2
RGS2	STAD	chr1	192779562	192779563	-	T	Splice_Site	p.Y92_splice	2
RGS2	LUAD	chr1	192779316	192779316	G	T	Missense_Mutation	p.R44L	2
RGS2	CESC	chr1	192778294	192778294	A	C	Missense_Mutation		2
RGS2	STAD	chr1	192779563	192779564	-	T	Splice_Site	p.Y92_splice	2
RGS2	LUAD	chr1	192780233	192780233	A	G	Missense_Mutation	p.R133G	2
RGS2	CESC	chr1	192779519	192779519	C	T	Nonsense_Mutation	p.Q78*	2
RGS2	SARC	chr1	192778205	192778205	C	T	Nonsense_Mutation	p.Q2*	2
RGS2	ESCA	chr1	192778269	192778269	G	A	Missense_Mutation	p.G23D	2
RGS2	LUAD	chr1	192778207	192778207	A	T	Missense_Mutation	p.Q2H	2
RGS2	UCEC	chr1	192779335	192779335	A	G	Silent	p.Q50	2
RGS2	SKCM	chr1	192780138	192780138	T	C	Missense_Mutation	p.L101S	2
RGS2	UCEC	chr1	192780151	192780151	C	A	Missense_Mutation	p.F105L	2
RGS2	HNSC	chr1	192780144	192780144	C	T	Missense_Mutation	p.S103L	2
RGS2	UCEC	chr1	192780185	192780185	G	C	Missense_Mutation	p.E117Q	2
RGS2	UCEC	chr1	192780653	192780653	G	A	Missense_Mutation	p.R188H	2
RGS2	PAAD	chr1	192779364	192779364	C	T	Missense_Mutation		2
RGS2	STAD	chr1	192780194	192780194	A	-	Frame_Shift_Del	p.F119fs	2
RGS2	KIRC	chr1	192780679	192780679	G	T	Missense_Mutation	p.D197Y	1
RGS2	COAD	chr1	192780136	192780136	T	G	Missense_Mutation	p.F100L	1
RGS2	STAD	chr1	192779562	192779563	-	T	Splice_Site	.	1
RGS2	LIHC	chr1	192778220	192778220	T	A	Missense_Mutation	p.L7M	1
RGS2	BLCA	chr1	192780193	192780193	C	G	Missense_Mutation		1
RGS2	PAAD	chr1	192778279	192778279	C	T	Silent	p.S26S	1
RGS2	COAD	chr1	192780685	192780685	T	A	Missense_Mutation	p.C199S	1
RGS2	STAD	chr1	192778212	192778213	-	TA	Frame_Shift_Ins	p.D4fs	1
RGS2	LIHC	chr1	192780133	192780133	T	-	Frame_Shift_Del	p.A99fs	1
RGS2	BLCA	chr1	192780570	192780570	G	T	Missense_Mutation		1
RGS2	READ	chr1	192779534	192779534	G	T	Missense_Mutation	p.A83S	1
RGS2	COAD	chr1	192778205	192778205	C	T	Nonsense_Mutation	p.Q2X	1
RGS2	STAD	chr1	192780201	192780201	C	A	Missense_Mutation	p.T122N	1
RGS2	READ	chr1	192780207	192780207	C	A	Nonsense_Mutation	p.S124X	1
RGS2	ESCA	chr1	192780357	192780357	C	T	RNA	NULL	1
RGS2	TGCT	chr1	192778269	192778269	G	A	Missense_Mutation		1
RGS2	CESC	chr1	192780547	192780547	C	T	Nonsense_Mutation		1
RGS2	SARC	chr1	192778205	192778205	C	T	Nonsense_Mutation		1
RGS2	ESCA	chr1	192779527	192779527	G	T	Missense_Mutation		1
RGS2	LUAD	chr1	192778313	192778313	T	C	Splice_Site		1
RGS2	CESC	chr1	192779519	192779519	C	T	Nonsense_Mutation		1
RGS2	HNSC	chr1	192780144	192780144	C	T	Missense_Mutation		1
RGS2	LUAD	chr1	192778220	192778220	T	-	Frame_Shift_Del	p.L7fs	1
RGS2	COAD	chr1	192779368	192779369	-	A	Frame_Shift_Ins	p.G61fs	1
RGS2	STAD	chr1	192778212	192778213	-	-	Frame_Shift_Ins		1
RGS2	OV	chr1	191046765	191046765	G	A	Silent	p.K102	1
RGS2	COAD	chr1	192779369	192779369	A	-	Frame_Shift_Del	p.G61fs	1
RGS2	STAD	chr1	192778212	192778213	-	TA	Frame_Shift_Ins	p.A4fs	1
RGS2	HNSC	chr1	192778228	192778228	T	C	Silent	p.V9V	1
RGS2	COAD	chr1	192780124	192780124	A	G	Silent	p.A96A	1

Copy number variation (CNV) of RGS2
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RGS2
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
52081	N/A	AU119852	BUB1	chr2	111425124	-	RGS2	chr1	192780565	+
52091	N/A	CD558589	MBP	chr18	74724750	-	RGS2	chr1	192780233	+

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
TGCT	RGS2	0.0088921007555244	0.25
BLCA	RGS2	0.0168560551652814	0.46
ACC	RGS2	0.0262318622571054	0.68

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
THCA	RGS2	0.0346810966374376	0.96
LAML	RGS2	0.0331662397233757	0.96
BRCA	RGS2	3.17572715843045e-05	0.001
PAAD	RGS2	0.0260365934844824	0.78
ESCA	RGS2	0.0344580153754989	0.96
BLCA	RGS2	0.00228431138428586	0.073
PCPG	RGS2	0.0063676916028114	0.2

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0036341	Schizophrenia	2	PSYGENET
C0006142	Malignant neoplasm of breast	1	CTD_human
C0023467	Leukemia, Myelocytic, Acute	1	CTD_human
C0023893	Liver Cirrhosis, Experimental	1	CTD_human
C0024623	Malignant neoplasm of stomach	1	CTD_human
C0026998	Acute Myeloid Leukemia, M1	1	CTD_human
C0030569	Secondary Parkinson Disease	1	CTD_human
C0678222	Breast Carcinoma	1	CTD_human
C0751414	Parkinson Disease, Secondary Vascular	1	CTD_human
C0751415	Atherosclerotic Parkinsonism	1	CTD_human
C1257931	Mammary Neoplasms, Human	1	CTD_human
C1708349	Hereditary Diffuse Gastric Cancer	1	CTD_human
C1879321	Acute Myeloid Leukemia (AML-M2)	1	CTD_human
C4704874	Mammary Carcinoma, Human	1	CTD_human