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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPL7A (NCBI Gene ID:6130)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPL7A
	Gene ID: 6130
	Gene Symbol	RPL7A
	Gene ID	6130
	Gene Name	ribosomal protein L7a
	Synonyms	L7A\|SURF3\|TRUP
	Cytomap	9q34.2
	Type of Gene	protein-coding
	Description	60S ribosomal protein L7aPLA-X polypeptidelarge ribosomal subunit protein eL8surfeit 3surfeit locus protein 3thyroid hormone receptor uncoupling protein
	Modification date	20200313
	UniProtAcc	P62424

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
RPL7A	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'RPL7A[title] AND translation [title] AND human.'

Gene	Title	PMID
RPL7A	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000323345	136216405	136216555	In-frame
ENST00000323345	136216766	136216907	In-frame
ENST00000323345	136217094	136217174	Frame-shift
ENST00000323345	136217451	136217582	Frame-shift
ENST00000323345	136217856	136217926	Frame-shift

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000323345	136216405	136216555	908	155	304	266	41	91
ENST00000323345	136216766	136216907	908	305	445	266	91	138

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
P62424	41	91	1	266	Chain	ID=PRO_0000136747;Note=60S ribosomal protein L7a
P62424	91	138	1	266	Chain	ID=PRO_0000136747;Note=60S ribosomal protein L7a
P62424	91	138	97	97	Modified residue	Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:19608861;Dbxref=PMID:19608861
P62424	41	91	48	48	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
P62424	91	138	97	97	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
P62424	91	138	125	125	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
PRAD	RPL7A	1.06743884070038	0.000154375047072011
BRCA	RPL7A	-3.09126464965734	0.000158086090138015
COAD	RPL7A	2.30353494294397	0.00197160243988037
KIRP	RPL7A	-1.79156602133961	0.00647870777174831
THCA	RPL7A	2.29001383761444	1.71901813744324e-05
KIRC	RPL7A	-3.59348738398833	5.5547256801368e-06

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
CESC	RPL7A	-0.040538466	0.008362236
PAAD	RPL7A	0.129958572	0.038838989
BLCA	RPL7A	-0.039699662	0.041077557
LUAD	RPL7A	0.068351878	0.04643871

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPL7A (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	TF	RPL7A	REXO4	0.835401543	9.55E-13
DLBC	Cell metabolism gene	RPL7A	GEMIN7	0.80925304	3.38E-12
DLBC	Cell metabolism gene	RPL7A	TOMM22	0.8164306	1.52E-12
DLBC	Cell metabolism gene	RPL7A	PFDN5	0.819602744	1.05E-12
DLBC	Cell metabolism gene	RPL7A	TIMM9	0.820816796	9.15E-13
DLBC	Cell metabolism gene	RPL7A	FAU	0.836922203	1.26E-13
DLBC	Cell metabolism gene	RPL7A	NME2	0.847909826	2.87E-14
DLBC	Cell metabolism gene	RPL7A	SNRPD2	0.861723911	3.76E-15
DLBC	CGC	RPL7A	NACA	0.873297408	5.73E-16
DLBC	Epifactor	RPL7A	FBL	0.826084878	4.90E-13
DLBC	TF	RPL7A	REXO4	0.808866721	3.52E-12
DLBC	TF	RPL7A	NME2	0.847909826	2.87E-14
DLBC	TSG	RPL7A	GADD45GIP1	0.806145424	4.72E-12
DLBC	TSG	RPL7A	GLTSCR2	0.820421896	9.59E-13
DLBC	TSG	RPL7A	GNB2L1	0.936771402	1.32E-22
GBM	TSG	RPL7A	GAS5	0.803026335	4.62E-40
LGG	Cell metabolism gene	RPL7A	FAU	0.829228272	1.65E-135
LGG	CGC	RPL7A	NACA	0.833438093	4.14E-138
LGG	TSG	RPL7A	GAS5	0.821019814	1.23E-130
LGG	TSG	RPL7A	GNB2L1	0.869859374	3.66E-164
PAAD	TSG	RPL7A	GNB2L1	0.806495797	3.58E-43
PCPG	TSG	RPL7A	GNB2L1	0.872970354	1.40E-59
PRAD	Cell metabolism gene	RPL7A	TIMM9	0.801481069	1.85E-124
PRAD	Cell metabolism gene	RPL7A	NME2	0.805230557	1.76E-126
PRAD	CGC	RPL7A	NACA	0.877606252	4.00E-177
PRAD	TF	RPL7A	NME2	0.805230557	1.76E-126
PRAD	TSG	RPL7A	GAS5	0.820713989	2.49E-135
PRAD	TSG	RPL7A	GNB2L1	0.925416734	4.26E-233
THCA	TSG	RPL7A	GAS5	0.80824369	3.29E-133
THCA	TSG	RPL7A	GNB2L1	0.86245019	1.05E-170
THYM	Cell metabolism gene	RPL7A	TIMM13	0.801170495	1.58E-28
THYM	Cell metabolism gene	RPL7A	DPM3	0.802634679	1.06E-28
THYM	Cell metabolism gene	RPL7A	SLC27A5	0.805020778	5.52E-29
THYM	Cell metabolism gene	RPL7A	TIMM8B	0.809573928	1.55E-29
THYM	Cell metabolism gene	RPL7A	APRT	0.810845582	1.08E-29
THYM	Cell metabolism gene	RPL7A	TOMM7	0.8131913	5.49E-30
THYM	Cell metabolism gene	RPL7A	PFDN5	0.820184087	6.96E-31
THYM	Cell metabolism gene	RPL7A	PSMB7	0.82059891	6.14E-31
THYM	Cell metabolism gene	RPL7A	DPM2	0.822535119	3.40E-31
THYM	Cell metabolism gene	RPL7A	POLR2I	0.827780525	6.64E-32
THYM	Cell metabolism gene	RPL7A	SNRPD2	0.830371086	2.90E-32
THYM	Cell metabolism gene	RPL7A	TOMM22	0.840231562	1.09E-33
THYM	Cell metabolism gene	RPL7A	POLR2F	0.847042028	9.89E-35
THYM	Cell metabolism gene	RPL7A	PGLS	0.854137306	7.14E-36
THYM	Cell metabolism gene	RPL7A	SSR2	0.858600405	1.27E-36
THYM	Cell metabolism gene	RPL7A	FAU	0.867750863	3.05E-38
THYM	Epifactor	RPL7A	ZNHIT1	0.809623509	1.53E-29
THYM	Epifactor	RPL7A	TAF10	0.812796261	6.16E-30
THYM	Epifactor	RPL7A	FBL	0.840275863	1.07E-33
THYM	IUPHAR	RPL7A	SLC27A5	0.805020778	5.52E-29
THYM	TF	RPL7A	ZNF581	0.83436829	7.88E-33
THYM	TSG	RPL7A	PARK7	0.805151871	5.32E-29
THYM	TSG	RPL7A	GLTSCR2	0.840880436	8.71E-34
THYM	TSG	RPL7A	GNB2L1	0.872224227	4.45E-39
UCS	Cell metabolism gene	RPL7A	TIMM13	0.801170495	1.58E-28
UCS	Cell metabolism gene	RPL7A	DPM3	0.802634679	1.06E-28
UCS	Cell metabolism gene	RPL7A	SLC27A5	0.805020778	5.52E-29
UCS	Cell metabolism gene	RPL7A	TIMM8B	0.809573928	1.55E-29
UCS	Cell metabolism gene	RPL7A	APRT	0.810845582	1.08E-29
UCS	Cell metabolism gene	RPL7A	TOMM7	0.8131913	5.49E-30
UCS	Cell metabolism gene	RPL7A	PFDN5	0.820184087	6.96E-31
UCS	Cell metabolism gene	RPL7A	PSMB7	0.82059891	6.14E-31
UCS	Cell metabolism gene	RPL7A	DPM2	0.822535119	3.40E-31
UCS	Cell metabolism gene	RPL7A	POLR2I	0.827780525	6.64E-32
UCS	Cell metabolism gene	RPL7A	SNRPD2	0.830371086	2.90E-32
UCS	Cell metabolism gene	RPL7A	TOMM22	0.840231562	1.09E-33
UCS	Cell metabolism gene	RPL7A	POLR2F	0.847042028	9.89E-35
UCS	Cell metabolism gene	RPL7A	PGLS	0.854137306	7.14E-36
UCS	Cell metabolism gene	RPL7A	SSR2	0.858600405	1.27E-36
UCS	Cell metabolism gene	RPL7A	FAU	0.867750863	3.05E-38
UCS	Epifactor	RPL7A	ZNHIT1	0.809623509	1.53E-29
UCS	Epifactor	RPL7A	TAF10	0.812796261	6.16E-30
UCS	Epifactor	RPL7A	FBL	0.840275863	1.07E-33
UCS	IUPHAR	RPL7A	SLC27A5	0.805020778	5.52E-29
UCS	TF	RPL7A	ZNF581	0.83436829	7.88E-33
UCS	TSG	RPL7A	PARK7	0.805151871	5.32E-29
UCS	TSG	RPL7A	GLTSCR2	0.840880436	8.71E-34
UCS	TSG	RPL7A	GNB2L1	0.872224227	4.45E-39
UVM	Cell metabolism gene	RPL7A	POLR1E	0.804061008	2.71E-19
UVM	Cell metabolism gene	RPL7A	FAU	0.832015985	1.18E-21
UVM	CGC	RPL7A	NACA	0.878650689	9.26E-27
UVM	Epifactor	RPL7A	FBL	0.846840072	4.33E-23
UVM	TF	RPL7A	ZNF581	0.818167758	1.96E-20
UVM	TF	RPL7A	REXO4	0.832141288	1.15E-21
UVM	TSG	RPL7A	GNB2L1	0.886276801	8.55E-28
UVM	TSG	RPL7A	GLTSCR2	0.888404336	4.27E-28

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRP	RPL7A	RPL18A	-1.51651392808885	0.00016188295558095
KICH	RPL7A	RPS27A	1.75396693785956	0.000187873840332031
KIRP	RPL7A	RPS16	-1.35957043617517	0.00019507110118866
COAD	RPL7A	RPS3	1.48730375143014	0.000411599874496461
KIRP	RPL7A	RPS11	-1.01861570565103	0.00105937570333481
LIHC	RPL7A	RPL8	-4.84588284974558	0.00110314154326131
PRAD	RPL7A	RPL18A	1.40600175748499	0.00205137828390396
KICH	RPL7A	RPL19	1.36901182894089	0.00250792503356934
KICH	RPL7A	RPS12	1.26997381758431	0.00308787822723389
LUAD	RPL7A	RPL19	-1.31398026615725	0.00993159558412698
THCA	RPL7A	RPS16	-6.16322798156577	0.0115764821363307
BLCA	RPL7A	RPS12	-1.47804673440421	0.0204124450683594
BLCA	RPL7A	RPS27A	-1.04747470069188	0.0258216857910156
HNSC	RPL7A	RPS3	-4.73505819095135	0.0273726439852453
COAD	RPL7A	RPS11	1.35307548998204	0.0312207043170929
LUSC	RPL7A	RPL19	-2.14669889516666	0.044366810398747
KIRC	RPL7A	RPL19	-2.73485271276676	1.33980982873695e-10
BRCA	RPL7A	RPS12	-4.91239327478244	1.85340619742495e-09
KIRP	RPL7A	RPL37	-1.17421621947139	2.26888805627823e-05
KIRC	RPL7A	RPL35	-1.06475238059392	2.72286325678163e-08
KIRC	RPL7A	RPL8	-1.18252459971773	5.64962994208288e-07
KIRP	RPL7A	RPL8	-1.53003692350119	6.0301274061203e-05
KIRC	RPL7A	RPS16	-1.66149869889384	7.8509870430991e-09
BRCA	RPL7A	RPS27A	-4.28512148200424	7.8788217967112e-14
KIRC	RPL7A	RPL37	-2.87198822058464	8.03913394748564e-12
KIRP	RPL7A	RPL35	-1.52981101975496	9.0546440333128e-05
KIRC	RPL7A	RPS3	-1.29560847926387	9.05905681935088e-10
KIRC	RPL7A	RPL18A	-4.43079304960843	9.2516163152192e-11

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPL7A

POLR2M, MKNK2, SRRM2, ESR1, HDAC5, DYRK2, STAU1, EBNA-LP, VHL, ARRB1, ARRB2, SIRT7, ERG, NFX1, CUL3, CUL4A, RPL10A, RPL21, RPL6, RPL7, RPS3A, RPS3, RPL4, RPS9, RPLP0, RPL11, RPL12, RPL13, RPL14, RPL15, RPL17, RPL18A, RPL18, RPL19, RPL23, RPL27A, RPL30, RPL31, RPL5, RPL8, RPL9, RPS13, RPS15A, RPS16, RPS19, RPS20, RPS23, RPS25, RPS26, RPS28, RPS2, RPS4X, RPS5, RPS8, RPSA, RPL3, RPS6, RPS24, RPS12, RPL23A, RPL37A, RPL24, RPS11, RPL22, RPL10, RPL36, RPS14, RPL35, RPLP1, RPL38, RPS27A, RPS21, RPL32, EEF2, EEF1A1, RPL29, NCL, HNRNPU, ILF2, ILF3, SLC25A5, HSP90AB1, EEF1B2, PABPC1, HNRNPM, ACTA2, LUC7L2, RPS27L, GNB2L1, RPLP0P6, RPL10L, SLC25A6, PSMB1, MRPL12, UPF1, MAGOH, EIF4A3, FN1, VCAM1, UBL4A, ITGA4, PAN2, IGSF8, ICAM1, CTBP2, SOCS3, FBXO6, TARDBP, TRAP1, PARK2, AIMP1, DARS, EEF1E1, QARS, RPL26, EIF2S1, CEP250, TP53, HUWE1, CUL7, OBSL1, CCDC8, EED, RNF2, UBC, NPM1, LGALS3, NTRK1, DDX18, PES1, RPL26L1, RPL35A, RPL3L, BRIX1, RPL13A, RPL27, RPL34, RPS10, LOC101929876, RPS27, RPLP2, RPS15, RPS18, RPS7, SFN, EWSR1, XPO1, HIST1H3E, TTK, NOP56, Eif3a, Eif3e, Ktn1, Rpl35, Srp72, Rrbp1, MCM2, Ksr1, ZNF746, CDH1, RRS1, KIAA0020, MECP2, KNOP1, SART3, EBNA1BP2, ZC3HAV1, GPATCH4, MAK16, RBM34, BHLHA15, DGCR8, RRP8, ZNF2, CNBP, RPL28, H2AFY2, GLTSCR2, CYLD, INO80B, TRIM25, BRCA1, YAP1, MTF1, TMPO, WDR77, DIMT1, PCBP1, PPP6C, TRIP4, CTNNB1, GSK3A, MAP2K1, UBE2M, PYHIN1, PRPF8, EFTUD2, AAR2, PIH1D1, RPTOR, RNF4, CHD3, CHD4, LARP7, TNF, RIOK1, HEXIM1, MEPCE, PPT1, HERC2, RNF181, SNAI1, AGR2, RECQL4, DCPS, GPC1, REST, MYC, CDK9, Prkaa1, Prkab1, RPS6KB2, GRWD1, METTL14, RC3H1, RC3H2, PHB, FAF1, RBX1, KIN, NR2C2, PPP1CC, PPARG, VRK1, HIST1H4A, APEX1, SNRNP70, Dppa3, MTMR2, PTPN6, ITFG1, HMGB1, BIRC3, WWP2, BRD7, MATR3, Dnajc17, CMTR1, ARIH2, TFCP2, FANCD2, HCVgp1, ZC3H18, GAB2, MAP3K14, EMC4, ANXA6, SYNE2, NOLC1, TMEM35, ULK4, ZHX3, CACYBP, RSL1D1, RPL7L1, MYH14, FAM160A2, HIST1H2BH, ASNS, C9orf171, CHD7, SNIP1, ANKRD55, ATRX, E, M, N, nsp13, nsp2, nsp4, nsp5, nsp6, ORF14, ORF3a, ORF6, ORF7a, ORF7b, DUX4, CIT, ANLN, AURKB, CHMP4B, CHMP4C, ECT2, KIF14, KIF23, PRC1, LRRC59, INS, NMRAL1, NDN, BRD4, Apc2, RBM39, FBP1, LGALS9, IFI16, RIN3, DNAJC15, DNAJC16, DNAJC19, DNAJC1, DNAJC21, DNAJC25, DNAJC28, DNAJC2, DNAJC8, DRG1, DNAJB7, SETD8, H1FX, CBX6, KDM2A, REXO4, RALY, REPIN1, CBX8, HIST1H2AI, SMYD3, BAG5, DDRGK1, UFL1, CD3EAP, COIL, LCK, LMAN1, LYN, NUP155, PANX1, PEX3, PTK2, RAB35, RHOB, SERBP1, SSR1, ZNF330, TRIM37, ATG10, ATG3, FZR1, WDR5, PAGE4, NUDCD2, NAA40, PRKRA, KRR1, TUBA8, ZBTB24, ADARB1, ZSCAN25, DDX21, SART1, DDX31, MYBBP1A, LAD1, APOBEC3F, H1FOO, CENPU, PWP1, ZNF22, MRPL57, ZNF189, WHSC1, C8orf33, ZNF668, CENPQ, SPPL3, NSA2, RPL36AL, SRPK3, PAK1IP1, ZBTB47, PRDM5, SF3B2, YBX1, MRPS25, CENPN, CCDC137, ZNF48, RPF2, CCDC140, GLE1, PRDM15, PCDHGC4, ZFP62, ZNF317, ZNF16, GZF1, SRSF6, NOP2, RBMX2, DDX27, GLYR1, CDC42BPA, SIRT1, SURF6, PAPD5, TOE1, RBM28, ZC3H10, LLPH, SRSF1, PPAN-P2RY11, TERF1, H2AFX, SRP68, SRSF3, MAGEB2, RBM19, VPRBP, RBM4, NVL, HIST1H1T, ZNF770, PRKRIR, ZBTB41, DDX50, TRIM56, DHX30, WDR74, RSBN1, WDR46, ZFP91, BOP1, PHAX, SRPK2, HIST1H1A, UTP3, NGDN, DDX10, RPF1, TTF1, ABT1, SPATS2, IMP3, TRIP12, ZNF512, CCDC59, YTHDC2, FAM111A, HIST1H2AG, RPS4Y2, NOL6, GAR1, SPATS2L, DDX54, DDX56, CUL4B, RRP1B, STAU2, CDC5L, KCTD5, TAF1C, CTCF, HIST2H2AB, YBX3, PURB, EPB41L5, C7orf50, DDA1, GTPBP4, ZCCHC7, CEBPZ, PRDM10, NIP7, BMS1, ZNF771, LUC7L, NIFK, AATF, GTPBP10, HIST1H1E, FYTTD1, ZNF768, IMP4, RRP15, UTP14A, HIST2H2BF, UTP18, SPTY2D1, NOC2L, NKRF, NOL10, TAF1D, HIST1H2BO, NMNAT1, DKC1, POP1, BUD13, MRPL52, EPB41L4B, NOL12, FCF1, ZNF574, DICER1, NOC3L, DDX24, HJURP, RSBN1L, ZC3H3, KRI1, ZCRB1, APOBEC3C, NOM1, FTSJ3, NOP16, C1orf35, GNL2, MPHOSPH10, RSL24D1, C14orf169, MRPS16, DTX3, SPRTN, BTF3, TRIM26, FBXW7, NLRP7, FGD5, RCHY1, CCNF, NBR1, TAX1BP1, TMEM192, ZEB1,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPL7A	KIRP	chr9	136216489	136216489	C	A	Missense_Mutation	p.L70I	3
RPL7A	PAAD	chr9	136218201	136218201	C	T	Missense_Mutation	p.L261F	3
RPL7A	GBM	chr9	136217156	136217156	C	T	Silent	p.H159H	3
RPL7A	UCEC	chr9	136216773	136216773	A	G	Missense_Mutation	p.Q94R	3
RPL7A	LIHC	chr9	136216457	136216457	G	A	Missense_Mutation	p.R59H	3
RPL7A	ESCA	chr9	136218133	136218133	G	A	Missense_Mutation	p.G238D	2
RPL7A	STAD	chr9	136217103	136217103	A	G	Missense_Mutation	p.T142A	2
RPL7A	KIRP	chr9	136216909	136216909	T	A	Splice_Site		2
RPL7A	KIRP	chr9	136215863	136215863	C	A	Silent		2
RPL7A	CESC	chr9	136217463	136217463	C	G	Missense_Mutation	p.F169L	2
RPL7A	STAD	chr9	136217921	136217921	G	A	Missense_Mutation	p.D231N	2
RPL7A	UCEC	chr9	136217157	136217157	G	A	Missense_Mutation	p.D160N	2
RPL7A	STAD	chr9	136217531	136217531	G	A	Missense_Mutation	p.R192H	2
RPL7A	CESC	chr9	136216849	136216849	G	A	Silent		1
RPL7A	LUAD	chr9	136217159	136217159	C	T	Silent	p.D160D	1
RPL7A	KIRP	chr9	136216489	136216489	C	A	Missense_Mutation		1
RPL7A	CESC	chr9	136215622	136215622	C	G	Missense_Mutation		1
RPL7A	LUSC	chr9	136216887	136216887	G	C	Missense_Mutation	p.R132T	1
RPL7A	ESCA	chr9	136217908	136217909	-	-	Frame_Shift_Ins		1
RPL7A	STAD	chr9	136217870	136217870	G	A	Missense_Mutation	p.A214T	1
RPL7A	CESC	chr9	136215623	136215623	G	A	Missense_Mutation		1
RPL7A	MESO	chr9	136215833	136215833	G	A	Silent		1
RPL7A	ESCA	chr9	136217908	136217909	-	A	Frame_Shift_Ins	p.Y226fs	1
RPL7A	STAD	chr9	136216817	136216819	GAG	-	In_Frame_Del	p.E109del	1
RPL7A	MESO	chr9	136215833	136215833	G	A	Silent	p.K20K	1
RPL7A	ESCA	chr9	136217908	136217909	-	A	Frame_Shift_Ins	p.*227fs	1
RPL7A	TGCT	chr9	136215642	136215642	T	C	Silent		1
RPL7A	LGG	chr9	136216484	136216484	C	G	Missense_Mutation	p.A68G	1
RPL7A	CESC	chr9	136215803	136215803	G	C	Missense_Mutation	p.K10N	1
RPL7A	THCA	chr9	136216882	136216882	G	A	Silent		1
RPL7A	LGG	chr9	136217156	136217156	C	T	Silent		1
RPL7A	CESC	chr9	136216355	136216355	G	A	RNA	NULL	1
RPL7A	PAAD	chr9	136218131	136218131	G	T	Missense_Mutation	p.W237C	1
RPL7A	GBM	chr9	136217480	136217480	G	A	Missense_Mutation		1
RPL7A	THYM	chr9	136215641	136215641	G	T	Missense_Mutation		1
RPL7A	LIHC	chr9	136216457	136216457	G	A	Missense_Mutation		1
RPL7A	CESC	chr9	136216849	136216849	G	A	Silent	p.E119	1
RPL7A	PAAD	chr9	136218201	136218201	C	T	Missense_Mutation		1
RPL7A	HNSC	chr9	136216806	136216806	A	G	Missense_Mutation		1
RPL7A	THYM	chr9	136216476	136216476	G	T	Silent	p.R65R	1
RPL7A	LIHC	chr9	136216547	136216547	G	T	Missense_Mutation	p.R89L	1
RPL7A	COAD	chr9	136217511	136217511	G	T	Missense_Mutation	p.K185N	1
RPL7A	PRAD	chr9	136216453	136216453	C	T	Missense_Mutation	p.P58S	1
RPL7A	HNSC	chr9	136216806	136216806	A	G	Missense_Mutation	p.E105G	1
RPL7A	BLCA	chr9	136216479	136216479	G	A	Silent	p.Q66Q	1
RPL7A	ESCA	chr9	136215087	136215087	C	T	RNA	NULL	1
RPL7A	KIRP	chr9	136216882	136216882	G	T	Silent	p.T130T	1
RPL7A	CESC	chr9	136217463	136217463	C	G	Missense_Mutation		1
RPL7A	LIHC	chr9	136217542	136217542	A	G	Missense_Mutation	p.R196G	1
RPL7A	ESCA	chr9	136217061	136217061	C	A	RNA	NULL	1
RPL7A	KIRP	chr9	136215842	136215842	G	A	Silent	p.E23E	1
RPL7A	CESC	chr9	136215803	136215803	G	C	Missense_Mutation		1
RPL7A	LIHC	chr9	136215815	136215815	G	C	Silent	p.P14P	1
RPL7A	ESCA	chr9	136217908	136217909	-	A	Frame_Shift_Ins	p.N226fs	1
RPL7A	STAD	chr9	136216817	136216819	GAG	-	In_Frame_Del	p.108_109del	1

Copy number variation (CNV) of RPL7A
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RPL7A
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
93812	BLCA	TCGA-BT-A2LA-01A	ALDOA	chr16	30080710	+	RPL7A	chr9	136216856	+
93812	N/A	AA730283	DYNC1I1	chr7	95539052	+	RPL7A	chr9	136218263	-
93812	N/A	N63331	DYNC1I1	chr7	95539052	+	RPL7A	chr9	136218281	-
93812	Non-Cancer	ERR188473	EEF1A1	chr6	74227596	-	RPL7A	chr9	136216850	+
93812	N/A	AA513486	GNB1L	chr22	19780172	-	RPL7A	chr9	136218281	-
93812	GBM	TCGA-19-5960-01A	KIAA1524	chr3	108308121	-	RPL7A	chr9	136217095	+
93812	N/A	BP429635	PCNA	chr20	5100339	-	RPL7A	chr9	136217884	+
93812	Non-Cancer	ERR315469	PIM3	chr22	50355459	+	RPL7A	chr9	136215777	+
93812	STAD	TCGA-D7-A4Z0-01A	RCC1	chr1	28834672	+	RPL7A	chr9	136217452	+
93812	N/A	AI971016	RP11-170M17.1	chr10	65662144	+	RPL7A	chr9	136218267	-
83287	N/A	BI496018	RPL7A	chr9	136218281	+	ATP8B1	chr18	55442896	-
100841	N/A	AA483482	RPL7A	chr9	136218281	+	CTIF	chr18	46112667	-
102758	STAD	TCGA-CD-8530-01A	RPL7A	chr9	136215897	+	EIF4EBP1	chr8	37914599	+
95643	N/A	BI857300	RPL7A	chr9	136218256	+	GNB1L	chr22	19780070	+
100479	N/A	X06704	RPL7A	chr9	136215897	+	NTRK1	chr1	156844362	+
76990	N/A	BG033538	RPL7A	chr9	136218271	+	RP11-170M17.1	chr10	65662144	-
92887	N/A	BI856982	RPL7A	chr9	136218251	+	SEMA6D	chr15	48022318	-
88222	N/A	AA536044	RPL7A	chr9	136218281	+	SMOC1	chr14	70352030	-
88222	N/A	AA569274	RPL7A	chr9	136218275	+	SMOC1	chr14	70352026	+
88222	N/A	BF244002	RPL7A	chr9	136218278	+	SMOC1	chr14	70352468	-
88222	N/A	BG030245	RPL7A	chr9	136218271	+	SMOC1	chr14	70352417	-
88222	N/A	BG031929	RPL7A	chr9	136218281	+	SMOC1	chr14	70352019	-
88222	N/A	BI494614	RPL7A	chr9	136218281	+	SMOC1	chr14	70352494	-
88222	N/A	BI856078	RPL7A	chr9	136218281	+	SMOC1	chr14	70352040	-
88222	N/A	BI860007	RPL7A	chr9	136218281	+	SMOC1	chr14	70352026	-
88222	N/A	BM016159	RPL7A	chr9	136218281	+	SMOC1	chr14	70352005	-
88222	N/A	EC571116	RPL7A	chr9	136218279	+	SMOC1	chr14	70352040	-
103188	N/A	DA868683	RPL7A	chr9	136217768	+	ST7	chr7	116593398	+
93812	STAD	TCGA-D7-A4Z0-01A	SNHG3	chr1	28834672	+	RPL7A	chr9	136217452	+
93812	N/A	BI494613	SORCS1	chr10	108795017	-	RPL7A	chr9	136218281	-
93812	N/A	BQ027558	TRAPPC6B	chr14	39626309	-	RPL7A	chr9	136218281	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRC	RPL7A	0.0267981076712886	0.75
ACC	RPL7A	0.0415513780293678	1
MESO	RPL7A	0.0432363381123064	1
SARC	RPL7A	0.0479162406670265	1

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	RPL7A	0.011604101144296	0.36
GBM	RPL7A	0.0178057461295817	0.53
LGG	RPL7A	0.00441653078922317	0.14
BRCA	RPL7A	0.00321836224736069	0.11

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source