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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPL10 (NCBI Gene ID:6134)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPL10
	Gene ID: 6134
	Gene Symbol	RPL10
	Gene ID	6134
	Gene Name	ribosomal protein L10
	Synonyms	AUTSX5\|DXS648\|DXS648E\|L10\|MRXS35\|NOV\|QM
	Cytomap	Xq28
	Type of Gene	protein-coding
	Description	60S ribosomal protein L10Wilms tumor-related proteinlaminin receptor homologlarge ribosomal subunit protein uL16tumor suppressor QM
	Modification date	20200313
	UniProtAcc	P27635

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0005840	Ribosome
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
RPL10	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'RPL10[title] AND translation [title] AND human.'

Gene	Title	PMID
RPL10	The ribosomal RPL10 R98S mutation drives IRES-dependent BCL-2 translation in T-ALL	29930300

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000369817	153626837	153626883	5CDS-5UTR
ENST00000424325	153626837	153626883	5CDS-5UTR
ENST00000369817	153627678	153627737	Frame-shift
ENST00000424325	153627678	153627737	Frame-shift
ENST00000369817	153627827	153627935	In-frame
ENST00000424325	153627827	153627935	In-frame
ENST00000369817	153628143	153628282	Frame-shift
ENST00000424325	153628143	153628282	Frame-shift
ENST00000369817	153628804	153628967	Frame-shift
ENST00000424325	153628804	153628967	Frame-shift

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000369817	153627827	153627935	1301	659	766	214	27	63
ENST00000424325	153627827	153627935	2335	271	378	214	27	63

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
P27635	27	63	2	214	Chain	ID=PRO_0000147105;Note=60S ribosomal protein L10
P27635	27	63	2	214	Chain	ID=PRO_0000147105;Note=60S ribosomal protein L10
P27635	27	63	32	32	Modified residue	Note=Citrulline;Ontology_term=ECO:0000250;evidence=ECO:0000250
P27635	27	63	32	32	Modified residue	Note=Citrulline;Ontology_term=ECO:0000250;evidence=ECO:0000250
P27635	27	63	43	45	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2PA2
P27635	27	63	43	45	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2PA2
P27635	27	63	48	54	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2PA2
P27635	27	63	48	54	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2PA2
P27635	27	63	58	61	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2PA2
P27635	27	63	58	61	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2PA2
P27635	27	63	62	80	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2PA2
P27635	27	63	62	80	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2PA2

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
COAD	RPL10	2.006642468675	0.000363647937774659
KIRP	RPL10	-1.37220416357567	0.000397900585085154
THCA	RPL10	1.10728945731078	0.0162154270723803
UCEC	RPL10	-2.16361378541108	0.03125
KICH	RPL10	-2.34220425889432	0.0341737866401672
BRCA	RPL10	-3.68650055930356	5.03964579430268e-08

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
KIRP	RPL10	1	2	0.0334071173713668	0.076813961038961	0.405737125220459	0.79062394636975	1.35068734806345

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
ESCA	RPL10	-0.042604178	0.013840261
DLBC	RPL10	-0.021597072	0.016003874

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPL10 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
CHOL	CGC	RPL10	NACA	0.840652952	5.03E-13
CHOL	Epifactor	RPL10	FBL	0.814210109	1.03E-11
CHOL	TSG	RPL10	GNB2L1	0.819191175	6.06E-12
CHOL	TSG	RPL10	GLTSCR2	0.821366272	4.78E-12
DLBC	Cell metabolism gene	RPL10	IDH3G	0.81751023	1.34E-12
DLBC	CGC	RPL10	NACA	0.802093215	7.25E-12
DLBC	TSG	RPL10	GLTSCR2	0.826431281	4.69E-13
DLBC	TSG	RPL10	GNB2L1	0.861168537	4.10E-15
LAML	Cell metabolism gene	RPL10	FAU	0.838782931	5.14E-47
LAML	TSG	RPL10	GLTSCR2	0.839611164	3.44E-47
LGG	Cell metabolism gene	RPL10	IMPDH2	0.804948438	8.72E-122
LGG	Cell metabolism gene	RPL10	FAU	0.832522158	1.55E-137
LGG	CGC	RPL10	NACA	0.861204526	2.62E-157
LGG	IUPHAR	RPL10	IMPDH2	0.804948438	8.72E-122
LGG	TSG	RPL10	GAS5	0.824681608	8.86E-133
LGG	TSG	RPL10	GNB2L1	0.876018766	2.39E-169
PCPG	Epifactor	RPL10	FBL	0.817465935	3.38E-46
PCPG	TSG	RPL10	GLTSCR2	0.809276159	1.30E-44
PRAD	Epifactor	RPL10	FBL	0.822679867	1.63E-136
PRAD	TSG	RPL10	GNB2L1	0.84501319	4.26E-151
THCA	TSG	RPL10	GNB2L1	0.815503199	1.71E-137
THYM	Cell metabolism gene	RPL10	SNRPD2	0.801944051	1.28E-28
THYM	Cell metabolism gene	RPL10	POLR2F	0.802157992	1.21E-28
THYM	Cell metabolism gene	RPL10	WBSCR22	0.802774227	1.02E-28
THYM	Cell metabolism gene	RPL10	SSR2	0.805488406	4.85E-29
THYM	Cell metabolism gene	RPL10	IDH3G	0.808720157	1.97E-29
THYM	Cell metabolism gene	RPL10	PGLS	0.810134688	1.32E-29
THYM	Cell metabolism gene	RPL10	TAZ	0.840466014	1.01E-33
THYM	Cell metabolism gene	RPL10	TOMM22	0.841082744	8.12E-34
THYM	Epifactor	RPL10	FBL	0.805249098	5.18E-29
THYM	TSG	RPL10	GLTSCR2	0.826695177	9.36E-32
THYM	TSG	RPL10	GNB2L1	0.828341068	5.56E-32
UCS	Cell metabolism gene	RPL10	SNRPD2	0.801944051	1.28E-28
UCS	Cell metabolism gene	RPL10	POLR2F	0.802157992	1.21E-28
UCS	Cell metabolism gene	RPL10	WBSCR22	0.802774227	1.02E-28
UCS	Cell metabolism gene	RPL10	SSR2	0.805488406	4.85E-29
UCS	Cell metabolism gene	RPL10	IDH3G	0.808720157	1.97E-29
UCS	Cell metabolism gene	RPL10	PGLS	0.810134688	1.32E-29
UCS	Cell metabolism gene	RPL10	TAZ	0.840466014	1.01E-33
UCS	Cell metabolism gene	RPL10	TOMM22	0.841082744	8.12E-34
UCS	Epifactor	RPL10	FBL	0.805249098	5.18E-29
UCS	TSG	RPL10	GLTSCR2	0.826695177	9.36E-32
UCS	TSG	RPL10	GNB2L1	0.828341068	5.56E-32
UVM	Cell metabolism gene	RPL10	IMPDH2	0.807693209	1.41E-19
UVM	Cell metabolism gene	RPL10	SSR2	0.853047136	9.75E-24
UVM	Cell metabolism gene	RPL10	FAU	0.856803828	3.83E-24
UVM	Epifactor	RPL10	TRIM28	0.823515642	6.81E-21
UVM	Epifactor	RPL10	FBL	0.896301306	2.85E-29
UVM	IUPHAR	RPL10	IMPDH2	0.807693209	1.41E-19
UVM	IUPHAR	RPL10	TRIM28	0.823515642	6.81E-21
UVM	Kinase	RPL10	TRIM28	0.823515642	6.81E-21
UVM	TF	RPL10	REXO4	0.829000318	2.22E-21
UVM	TF	RPL10	ZNF581	0.87961879	6.90E-27
UVM	TSG	RPL10	GLTSCR2	0.862629915	8.50E-25
UVM	TSG	RPL10	GNB2L1	0.875245259	2.55E-26

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRP	RPL10	RPL18A	-1.51651392808885	0.00016188295558095
KIRP	RPL10	RPS16	-1.35957043617517	0.00019507110118866
STAD	RPL10	RPS23	1.85076760664576	0.000364991836249828
COAD	RPL10	RPS3	1.48730375143014	0.000411599874496461
KIRP	RPL10	RPS11	-1.01861570565103	0.00105937570333481
LIHC	RPL10	RPL8	-4.84588284974558	0.00110314154326131
PRAD	RPL10	RPL18A	1.40600175748499	0.00205137828390396
KICH	RPL10	RPL19	1.36901182894089	0.00250792503356934
KICH	RPL10	RPS12	1.26997381758431	0.00308787822723389
LUAD	RPL10	RPL19	-1.31398026615725	0.00993159558412698
THCA	RPL10	RPS16	-6.16322798156577	0.0115764821363307
LUSC	RPL10	RPS23	1.46751169891047	0.0174932185880974
BLCA	RPL10	RPS12	-1.47804673440421	0.0204124450683594
HNSC	RPL10	RPS3	-4.73505819095135	0.0273726439852453
COAD	RPL10	RPS11	1.35307548998204	0.0312207043170929
COAD	RPL10	RPS9	1.18612014402235	0.0381683111190796
LUSC	RPL10	RPL19	-2.14669889516666	0.044366810398747
UCEC	RPL10	RPS23	-2.03658159814007	0.046875
KIRC	RPL10	RPL19	-2.73485271276676	1.33980982873695e-10
BRCA	RPL10	RPS12	-4.91239327478244	1.85340619742495e-09
BRCA	RPL10	RPS9	1.9331477546349	2.31299392089389e-07
KIRC	RPL10	RPL35	-1.06475238059392	2.72286325678163e-08
KIRC	RPL10	RPL8	-1.18252459971773	5.64962994208288e-07
KIRP	RPL10	RPL8	-1.53003692350119	6.0301274061203e-05
KIRC	RPL10	RPS9	-1.32680816440987	6.53264115309597e-07
KIRC	RPL10	RPS16	-1.66149869889384	7.8509870430991e-09
KIRP	RPL10	RPL35	-1.52981101975496	9.0546440333128e-05
KIRC	RPL10	RPS3	-1.29560847926387	9.05905681935088e-10
KIRC	RPL10	RPL18A	-4.43079304960843	9.2516163152192e-11

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPL10

TBPL1, YES1, SRC, LYN, FYN, HCK, SMN1, NOP56, STAU1, EBNA-LP, MAPK6, TAB1, RAD21, HDGF, SIRT7, CUL3, COPS5, CAND1, PRAME, RPL6, RPL9, RPS10, RPS15A, RPS23, RPS2, RPS4X, RPSA, RPS17, RPS16, RPL21, RPL7, RPS13, RPS24, RPL12, RPL19, RPL4, RPL14, RPS26, RPL23, RPL31, RPL3, RPS3A, RPL7A, RPL30, RPS7, RPL5, RPL27A, RPL8, RPL18, RPL11, RPL23A, RPL38, RPS21, ILF2, MOV10, HNRNPM, SLC25A3, SYNCRIP, RPLP0P6, SLC25A6, ESR1, MAGOH, EIF4A3, FN1, VCAM1, UBL4A, ITGA4, ILF3, SF3B1, PAN2, NPM1, TARDBP, QARS, DENR, AURKB, CEP250, TUBGCP3, CUL7, RNF2, FOXRED2, UBAC2, UBC, AAMP, NTRK1, ATP1B3, RPL13, RPL13A, RPL18A, RPL22, RPL24, RPL27, RPL35, RPLP2, RPS11, RPS12, RPS19, RPS20, RPS25, RPS6, RPL10A, RPL15, RPL26, RPL26L1, RPL35A, RPL36, RPL37A, RPLP0, RPLP1, RPS14, RPS15, RPS18, LOC101929876, RPS27, RPS3, RPS5, RPS8, RPS9, SFN, PARP1, BTF3, CHD1, CHD3, DDX1, DDX5, DHX9, DECR1, EIF1AX, EIF2B1, ERCC6, FBL, FMR1, GTF2B, GTF3C2, HIST1H1B, HDAC2, HNRNPU, IFI16, EIF3E, KIF22, MKI67, MLLT6, MPG, NACA, DRG1, NOP2, NTHL1, NVL, PA2G4, POLRMT, PPP1CC, EIF2AK2, RBM3, RFC2, RFC3, RFC4, RFC5, XRCC3, NES, AP4S1, NCBP2, WAPAL, CTDSPL2, PHAX, CBX8, NAF1, CNTROB, ENTHD2, SUCO, RPL17, RPL29, RPL32, RPS27A, RPS29, ATXN2, SKIV2L, SNRPB2, SRP14, SRP72, SRPR, TOP2A, TOP2B, UBTF, DEK, EPM2A, KAT6A, CHAF1B, PIP5K1A, SMARCA5, EIF3A, EIF3C, EIF3F, EIF3G, EIF3I, BANF1, SGPL1, DDX18, EIF2B4, EIF2B2, TOP3B, H1FX, BAZ1B, USP10, NEMF, DDX21, TTC37, JADE3, G3BP2, ABCF2, PDCD7, G3BP1, ALYREF, NPM3, GNB2L1, EMG1, NXF1, MYBBP1A, ZMYND11, POP4, MORF4L1, POP1, EBNA1BP2, PSIP1, WDR6, SUPT16H, PDAP1, DHX30, MRPS27, LARP4B, PRRC2C, RRP12, LARP1, GTPBP4, BRD1, NIPBL, CNOT10, IBTK, ANKRD17, PRPF31, SERBP1, GNL3, AATF, MRPL46, TBL2, PABPC1, PELP1, SND1, DIMT1, APOBEC3C, NOB1, UHRF1, PACSIN3, GNL2, GLTSCR2, HP1BP3, RRP15, TFB1M, MRTO4, HERC5, DDX47, EIF3L, NIP7, NOL7, YTHDF2, RTCB, TRMT112, NOP58, C14orf166, MRPL48, ZAK, SPIN2A, DHX29, GNL3L, GTPBP2, TEX10, NSUN2, FOCAD, YTHDF1, PAK1IP1, PHIP, RBM28, MTPAP, RNMTL1, NAT10, BRIX1, TMA16, LSG1, NOP10, LYAR, DDX27, TSR1, MEPCE, BCCIP, PNO1, DHX33, DDX24, AVEN, NUFIP2, USP36, DDX55, SCAF1, MYO1G, MEAF6, MRPL38, NOL6, SPATS2, DDX50, SPATA5L1, DDX54, CENPU, C14orf169, MUS81, TRMT1L, LAS1L, UTP23, PHF6, CMSS1, MINA, GTPBP10, ZNF622, ZNF598, DHX57, IMP4, LARP4, CCDC124, TSR3, FTSJ3, DNAJC21, CENPV, LEMD2, YTHDF3, H3F3C, Cbx1, Ect2, Eif3a, Eif3e, Myh3, Rbm8a, Rpl35, Srp72, Naa50, Rrbp1, Bag2, Cep120, Smo, CRY1, CRY2, MCM2, NF2, ZNF746, FLCN, CYLD, FOXA1, TRIM25, BRCA1, MTF1, CFTR, ARIH1, C14orf178, COPA, COX6C, EIF4G2, EMC4, EXOSC4, FARSA, GFI1B, MRPL22, OGFOD1, PPCS, RPL10, RRM1, SDHC, SNAPC1, ZNF574, FBXO7, CBX6, EGLN3, TMPO, WDR77, BMP4, CTNNB1, GSK3A, KRAS, MAP2K1, MATN2, PCBP1, PPIE, PPP6C, TGFB1, PYHIN1, PRPF8, EFTUD2, AAR2, PIH1D1, RNF4, CHD4, FAM188B, RIOK1, ESR2, HEXIM1, LARP7, RNF123, SNAI1, AGR2, RECQL4, WWP1, REST, RPS6KB2, C1orf106, GRWD1, METTL14, KIAA1429, RC3H1, RC3H2, ACTC1, PHB, RBX1, NR2C2, CTCF, VRK1, HIST1H4A, SNRNP70, MTMR2, PTPN6, ITFG1, ARAF, HMGB1, BIRC3, WWP2, MATR3, Dnajc17, TRIM28, CMTR1, ARIH2, PINK1, NGB, E6, PTEN, HCVgp1, ZC3H18, GRB7, MAP3K14, SRRM2, ANKRD55, nsp5, nsp6, ORF14, ORF7a, NEK4, DUX4, CIT, ANLN, CHMP4C, ECT2, KIF14, KIF20A, KIF23, PRC1, LRRC59, SUMO2, NDN, Rnf183, N, Apc2, RBM39, MKRN1, CUL4A, RIN3, OGT, PARK2, UFL1, DDRGK1, ARF6, C11orf52, IMPDH2, PTK2, TRIM37, FZR1, WDR5, PAGE4, NAA40, LTBP2, SORL1, FBLN5, PFDN5, ZNF496, UBAC1, FBN2, PFDN1, GGPS1, NEUROG3, HERC1, RBM23, LTBP4, LRP1B, ZNF579, PRMT7, NOTCH2, ZBTB24, VPRBP, YBX3, DICER1, PTCD3, PPP6R3, MRPS15, MRPS6, UBE2O, AIM1, ZNF668, MRPL28, MRPL10, MRPS18B, RSL24D1, OIT3, MRPL44, MRPL37, ZNF638, RBM34, NIFK, METTL17, MCAT, MRPL9, MRPL11, MRPL1, MRPS5, DKC1, LRP4, FRAS1, MRPS16, MRPL27, IFI30, STAU2, SURF6, CCDC137, KNOP1, MRPL18, MRPL3, MRPL39, GPATCH4, MRPL57, RPL10L, KIAA0232, MDM2, MAGEB2, MRPS24, ERAL1, RPF1, MRPS7, FTL, LUC7L, C7orf50, KRR1, MRPL24, MRPL20, DDX28, MRPS9, MRPS34, MRPL13, PRKRA, FAM111A, ICT1, MRPL16, DAP3, C1QBP, NOP16, PRKRIR, DDX56, MRPL17, KBTBD6, MRPL30, DDA1, RPF2, MRPS31, MRPS33, MRPL47, MRPS30, MRPS35, MRPS14, MRPL55, PTPRU, LTV1, MRPL40, MRPL41, NRD1, RPL7L1, NOC3L, MRPL23, MRPL15, DDX31, PDRG1, NOA1, MRPL2, INPP5K, DDX10, KIAA0020, PFDN6, KRI1, MRPS26, MRPS25, MRPS10, MRPS2, MALSU1, KBTBD7, MRPS11, MRPL43, TSPYL1, MRPL35, MRPS12, MRPS21, ANKRD28, ROCK2, ZBTB11, SENP3, FNTB, MRPS18C, MRPS18A, YBX1, PPAN-P2RY11, MRPL52, GADD45GIP1, LBR, SPRTN, FBXW7, NLRP7, RCHY1, CCNF, CALCOCO2, RB1CC1, KLF16,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
RPL10	chrX	153626738	G	A	single_nucleotide_variant	Benign	MENTAL_RETARDATION,_X-LINKED,_SYNDROMIC,_35	SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001623\|5_prime_UTR_variant,SO:0001627\|intron_variant
RPL10	chrX	153626857	C	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001623\|5_prime_UTR_variant	SO:0001623\|5_prime_UTR_variant
RPL10	chrX	153626868	G	A	single_nucleotide_variant	Likely_pathogenic	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPL10	chrX	153626892	T	A	single_nucleotide_variant	Benign	not_specified	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL10	chrX	153627669	T	C	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL10	chrX	153627866	G	A	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001627\|intron_variant
RPL10	chrX	153627942	C	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL10	chrX	153628139	C	T	single_nucleotide_variant	Uncertain_significance	MENTAL_RETARDATION,_X-LINKED,_SYNDROMIC,_35	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL10	chrX	153628144	C	T	single_nucleotide_variant	Pathogenic	MENTAL_RETARDATION,_X-LINKED,_SYNDROMIC,_35	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPL10	chrX	153628185	A	G	single_nucleotide_variant	Pathogenic	MENTAL_RETARDATION,_X-LINKED,_SYNDROMIC,_35\|not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPL10	chrX	153628189	G	C	single_nucleotide_variant	Uncertain_significance	MENTAL_RETARDATION,_X-LINKED,_SYNDROMIC,_35\|not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPL10	chrX	153628204	G	A	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant	SO:0001583\|missense_variant
RPL10	chrX	153628217	G	A	single_nucleotide_variant	Likely_benign	History_of_neurodevelopmental_disorder	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPL10	chrX	153628244	C	T	single_nucleotide_variant	Conflicting_interpretations_of_pathogenicity	History_of_neurodevelopmental_disorder\|not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
RPL10	chrX	153628798	A	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL10	chrX	153628822	G	A	single_nucleotide_variant	Uncertain_significance	MENTAL_RETARDATION,_X-LINKED,_SYNDROMIC,_35	SO:0001583\|missense_variant,SO:0001819\|synonymous_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001819\|synonymous_variant,SO:0001627\|intron_variant
RPL10	chrX	153628942	A	C	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant,SO:0001624\|3_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001624\|3_prime_UTR_variant,SO:0001627\|intron_variant
RPL10	chrX	153628954	C	G	single_nucleotide_variant	Uncertain_significance	Inborn_genetic_diseases	SO:0001583\|missense_variant,SO:0001624\|3_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001624\|3_prime_UTR_variant,SO:0001627\|intron_variant
RPL10	chrX	153628956	G	A	single_nucleotide_variant	Pathogenic	MENTAL_RETARDATION,_X-LINKED,_SYNDROMIC,_35	SO:0001583\|missense_variant,SO:0001624\|3_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001624\|3_prime_UTR_variant,SO:0001627\|intron_variant
RPL10	chrX	153628957	G	A	single_nucleotide_variant	Likely_pathogenic	not_provided	SO:0001583\|missense_variant,SO:0001624\|3_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001624\|3_prime_UTR_variant,SO:0001627\|intron_variant
RPL10	chrX	153628959	C	T	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant,SO:0001624\|3_prime_UTR_variant,SO:0001627\|intron_variant	SO:0001583\|missense_variant,SO:0001624\|3_prime_UTR_variant,SO:0001627\|intron_variant
RPL10	chrX	153628971	T	A	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001627\|intron_variant	SO:0001627\|intron_variant
RPL10	chrX	153629115	C	T	single_nucleotide_variant	Likely_pathogenic	MENTAL_RETARDATION,_X-LINKED,_SYNDROMIC,_35	SO:0001583\|missense_variant,SO:0001819\|synonymous_variant,SO:0001624\|3_prime_UTR_variant	SO:0001583\|missense_variant,SO:0001819\|synonymous_variant,SO:0001624\|3_prime_UTR_variant
RPL10	chrX	153629128	A	G	single_nucleotide_variant	Uncertain_significance	MENTAL_RETARDATION,_X-LINKED,_SYNDROMIC,_35	SO:0001583\|missense_variant,SO:0001624\|3_prime_UTR_variant	SO:0001583\|missense_variant,SO:0001624\|3_prime_UTR_variant
RPL10	chrX	153629155	A	.	single_nucleotide_variant	Benign	not_provided	SO:0001583\|missense_variant,SO:0001624\|3_prime_UTR_variant	SO:0001583\|missense_variant,SO:0001624\|3_prime_UTR_variant
RPL10	chrX	153629155	A	G	single_nucleotide_variant	Benign	History_of_neurodevelopmental_disorder\|not_specified	SO:0002073\|no_sequence_alteration	SO:0002073\|no_sequence_alteration
RPL10	chrX	153629166	C	A	single_nucleotide_variant	risk_factor	Autism,_susceptibility_to,_X-linked_5	SO:0001583\|missense_variant,SO:0001819\|synonymous_variant,SO:0001624\|3_prime_UTR_variant	SO:0001583\|missense_variant,SO:0001819\|synonymous_variant,SO:0001624\|3_prime_UTR_variant
RPL10	chrX	153629180	G	A	single_nucleotide_variant	Likely_benign	not_provided	SO:0001583\|missense_variant,SO:0001819\|synonymous_variant,SO:0001624\|3_prime_UTR_variant	SO:0001583\|missense_variant,SO:0001819\|synonymous_variant,SO:0001624\|3_prime_UTR_variant
RPL10	chrX	153629183	C	T	single_nucleotide_variant	Benign	History_of_neurodevelopmental_disorder\|not_provided	SO:0001583\|missense_variant,SO:0001819\|synonymous_variant,SO:0001624\|3_prime_UTR_variant	SO:0001583\|missense_variant,SO:0001819\|synonymous_variant,SO:0001624\|3_prime_UTR_variant
RPL10	chrX	153629189	C	G	single_nucleotide_variant	Uncertain_significance	Autism,_susceptibility_to,_X-linked_5\|not_provided	SO:0001583\|missense_variant,SO:0001624\|3_prime_UTR_variant	SO:0001583\|missense_variant,SO:0001624\|3_prime_UTR_variant
RPL10	chrX	153629197	G	A	single_nucleotide_variant	Uncertain_significance	not_provided	SO:0001583\|missense_variant,SO:0001624\|3_prime_UTR_variant	SO:0001583\|missense_variant,SO:0001624\|3_prime_UTR_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPL10	ESCA	chrX	153627911	153627911	G	A	Missense_Mutation	p.E56K	7
RPL10	BLCA	chrX	153629109	153629109	G	A	Missense_Mutation	p.E187K	3
RPL10	BLCA	chrX	153629057	153629057	G	C	Missense_Mutation	p.K169N	3
RPL10	BRCA	chrX	153628919	153628919	G	C	Silent	p.V148	3
RPL10	LGG	chrX	153628932	153628932	C	T	Missense_Mutation	p.R153C	3
RPL10	PAAD	chrX	153627922	153627922	G	A	Silent	p.Q59Q	3
RPL10	ESCA	chrX	153627911	153627911	G	A	Missense_Mutation		3
RPL10	UCEC	chrX	153628224	153628224	C	T	Missense_Mutation	p.L91F	2
RPL10	STAD	chrX	153628830	153628830	T	C	Missense_Mutation	p.F119L	2
RPL10	UCEC	chrX	153628886	153628886	C	T	Silent	p.S137	2
RPL10	SKCM	chrX	153628212	153628212	A	T	Missense_Mutation	p.I87F	2
RPL10	STAD	chrX	153628915	153628915	A	G	Missense_Mutation	p.H147R	2
RPL10	UCEC	chrX	153631277	153631277	C	A	Missense_Mutation	p.P23H	2
RPL10	SKCM	chrX	153628213	153628213	T	C	Missense_Mutation	p.I87T	2
RPL10	STAD	chrX	153626868	153626868	G	A	Missense_Mutation	p.R3H	2
RPL10	BRCA	chrX	153628228	153628228	A	C	Missense_Mutation	p.H92P	2
RPL10	SKCM	chrX	153628162	153628162	T	C	Missense_Mutation	p.I70T	2
RPL10	HNSC	chrX	153628946	153628946	C	G	Missense_Mutation	p.F157L	2
RPL10	BRCA	chrX	153628945	153628945	T	C	Missense_Mutation	p.F157S	2
RPL10	HNSC	chrX	153628938	153628938	G	A	Missense_Mutation	p.A155T	2
RPL10	STAD	chrX	153628811	153628811	A	G	Silent		2
RPL10	UCEC	chrX	153627716	153627716	C	T	Missense_Mutation	p.R21C	2
RPL10	STAD	chrX	153628811	153628811	A	G	Silent	p.Q112Q	2
RPL10	UCEC	chrX	153627724	153627724	C	T	Silent	p.C23	2
RPL10	PAAD	chrX	153627922	153627922	G	A	Silent		2
RPL10	UCEC	chrX	153627880	153627880	G	A	Silent	p.E45	2
RPL10	STAD	chrX	153627879	153627879	A	G	Missense_Mutation	p.E45G	2
RPL10	LGG	chrX	153628932	153628932	C	T	Missense_Mutation		1
RPL10	SKCM	chrX	153628953	153628953	C	T	Missense_Mutation	p.P124S	1
RPL10	GBM	chrX	153631649	153631649	G	A	Missense_Mutation	p.V105I	1
RPL10	LIHC	chrX	153628235	153628235	C	A	Missense_Mutation		1
RPL10	GBM	chrX	153628824	153628824	G	A	Missense_Mutation	p.G117S	1
RPL10	LIHC	chrX	153629200	153629200	T	C	Missense_Mutation	p.F163L	1
RPL10	BLCA	chrX	153627864	153627864	A	G	Missense_Mutation	p.K40R	1
RPL10	HNSC	chrX	153628181	153628181	G	T	Missense_Mutation		1
RPL10	LUAD	chrX	153628874	153628874	A	G	Silent	p.Q133Q	1
RPL10	STAD	chrX	153626864	153626864	G	A	Missense_Mutation	p.G2S	1
RPL10	LUAD	chrX	153628150	153628150	A	C	Missense_Mutation	p.E66A	1
RPL10	SKCM	chrX	153628232	153628232	C	T	Silent	p.P93P	1
RPL10	STAD	chrX	153629051	153629051	C	T	Silent	p.I167I	1
RPL10	LUAD	chrX	153627737	153627737	G	A	Translation_Start_Site		1
RPL10	SKCM	chrX	153628248	153628248	A	G	Missense_Mutation	p.I99V	1
RPL10	LGG	chrX	153627882	153627882	T	G	Missense_Mutation	p.F46C	1
RPL10	STAD	chrX	153631751	153631751	A	G	Missense_Mutation	p.I139V	1
RPL10	LUAD	chrX	153626736	153626736	G	T	Splice_Site		1
RPL10	COAD	chrX	153628249	153628249	T	C	Missense_Mutation	p.I99T	1
RPL10	SKCM	chrX	153628953	153628953	C	T	Missense_Mutation	p.P160S	1
RPL10	LGG	chrX	153627702	153627702	C	T	Missense_Mutation	p.P16L	1
RPL10	STAD	chrX	153631740	153631740	C	T	Missense_Mutation	p.P135L	1
RPL10	LUSC	chrX	153627841	153627841	C	A	Silent	p.R32R	1
RPL10	ESCA	chrX	153626899	153626899	G	T	RNA	NULL	1
RPL10	BLCA	chrX	153626803	153626803	C	G	Missense_Mutation		1
RPL10	LUSC	chrX	153628196	153628196	C	T	Silent	p.G81G	1
RPL10	LGG	chrX	153627702	153627702	C	T	Missense_Mutation		1
RPL10	BLCA	chrX	153627864	153627864	A	G	Missense_Mutation		1
RPL10	ESCA	chrX	153637474	153637474	C	G	Missense_Mutation		1
RPL10	STAD	chrX	153629051	153629051	C	T	Missense_Mutation	p.S113F	1
RPL10	LGG	chrX	153627882	153627882	T	G	Missense_Mutation		1
RPL10	BLCA	chrX	153629057	153629057	G	C	Missense_Mutation		1

Copy number variation (CNV) of RPL10
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across RPL10
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
97368	LUSC	TCGA-33-4566	ANXA2	chr15	60690141	-	RPL10	chrX	153626837	+
97368	LUSC	TCGA-33-4566	ANXA2	chr15	60690142	-	RPL10	chrX	153626838	+
97368	STAD	TCGA-BR-A4J5	DNAJC8	chr1	28559431	-	RPL10	chrX	153626837	+
97368	N/A	CB152554	FAM129A	chr1	184863247	-	RPL10	chrX	153626718	+
97368	N/A	BF222029	FBXL12	chr19	9930817	-	RPL10	chrX	153629254	-
97368	N/A	AI133627	PDXDC1	chr16	15120563	+	RPL10	chrX	153626845	+
97368	N/A	FN104944	PIGZ	chr3	196696237	-	RPL10	chrX	153628803	+
97368	N/A	BP428841	PRKCE	chr2	46095450	-	RPL10	chrX	153629254	-
100690	N/A	AA528381	RPL10	chrX	153629258	+	ASTN2	chr9	119943209	-
100690	N/A	BG033456	RPL10	chrX	153629254	+	ASTN2	chr9	119943299	-
95449	COAD	TCGA-AA-3956-01A	RPL10	chrX	153627935	+	C12orf57	chr12	7054934	+
75809	ESCA	TCGA-VR-A8EW	RPL10	chrX	153628282	+	CST4	chr20	23666614	-
98785	ACC	TCGA-OR-A5JT-01A	RPL10	chrX	153628542	+	DLK1	chr14	101195287	+
85302	N/A	AA516072	RPL10	chrX	153629254	+	FBXL12	chr19	9930944	+
85302	N/A	BF340497	RPL10	chrX	153629253	+	FBXL12	chr19	9931367	+
85302	N/A	BF342722	RPL10	chrX	153629258	+	FBXL12	chr19	9931195	+
85302	N/A	BI858338	RPL10	chrX	153629254	+	FBXL12	chr19	9930817	+
85302	N/A	BI859635	RPL10	chrX	153629254	+	FBXL12	chr19	9930861	+
94702	STAD	TCGA-CD-8531	RPL10	chrX	153626883	+	GNB2	chr7	100274974	+
78787	STAD	TCGA-BR-A4J8	RPL10	chrX	153628967	+	HTATIP2	chr11	20385782	+
99572	HNSC	TCGA-D6-A6ES	RPL10	chrX	153627891	+	KRT17	chr17	39777899	-
97696	Non-Cancer	TCGA-HU-A4G3-11A	RPL10	chrX	153628282	+	PGK1	chrX	77369512	+
99596	N/A	AW581181	RPL10	chrX	153629004	+	RNF213	chr17	78319032	-
97368	N/A	AA531213	RPL10	chrX	153629105	+	RPL10	chrX	153629073	-
97368	N/A	BQ065372	RPL10	chrX	153626847	+	RPL10	chrX	153626809	-
97368	N/A	CS190452	SLTM	chr15	59179228	-	RPL10	chrX	153628178	-
97368	N/A	EC579861	SPPL2A	chr15	51031868	-	RPL10	chrX	153629054	+
97378	N/A	AA551629	USP32	chr17	58406851	+	RPL10	chrX	153629254	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type	Translation factor	Coefficent	Hazard ratio	Wald test pval	Likelihool ratio pval	Logrank test pval	# samples
UVM	RPL10	0.350939745264894	-1.04714073616453	0.000301100735539905	0.000166839958147322	0.000129333917865728	80
LGG	RPL10	0.539116252901097	-0.617824048766948	0.000410815313075206	0.000302825817583017	0.000435178014167266	525
LGG	RPL10	0.508704178446476	-0.675888613217275	0.0136995943499248	0.00860122386055666	0.0129205191523642	525
READ	RPL10	0.273863100133239	-1.29512693200322	0.0183351136080617	0.0153140369378255	0.0193552952784558	103
MESO	RPL10	0.660391006806064	-0.414923184827094	0.0223309308392321	0.0170496418668963	0.0215450935464518	85
MESO	RPL10	0.660391006806064	-0.414923184827094	0.0223309308392321	0.0170496418668963	0.0215450935464518	85
CESC	RPL10	0.430038696389672	-0.843880082739643	0.0338430761762812	0.00949152271745915	0.0375220226153691	295
UCEC	RPL10	0.581934518724564	-0.541397348363048	0.0459932390274267	0.0442269273145769	0.0451002972476986	188

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRC	RPL10	0.000326270123098237	0.0091
TGCT	RPL10	0.000347115522938783	0.0094
COAD	RPL10	0.0168311949995929	0.44
SARC	RPL10	0.0321654449267344	0.8
MESO	RPL10	0.0321984765337079	0.8

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
BRCA	RPL10	0.0169320579771323	0.56
THYM	RPL10	0.0342010924935052	1

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0796250	PARTINGTON X-LINKED MENTAL RETARDATION SYNDROME	6	CLINGEN
C3275438	AUTISM, SUSCEPTIBILITY TO, X-LINKED 5	3	UNIPROT
C4478383	MENTAL RETARDATION, X-LINKED, SYNDROMIC, 35	3	GENOMICS_ENGLAND;UNIPROT
C0004352	Autistic Disorder	1	CTD_human
C0376358	Malignant neoplasm of prostate	1	CTD_human
C1961099	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	1	CGI;CTD_human