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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: RPL12 (NCBI Gene ID:6136)

Gene Summary

Gene Summary

Gene Information	Gene Name: RPL12
	Gene ID: 6136
	Gene Symbol	RPL12
	Gene ID	6136
	Gene Name	ribosomal protein L12
	Synonyms	L12
	Cytomap	9q33.3
	Type of Gene	protein-coding
	Description	60S ribosomal protein L12large ribosomal subunit protein uL11
	Modification date	20200313
	UniProtAcc	P30050

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0005840	Ribosome
GO:0002181	Cytoplasmic translation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
RPL12	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'RPL12[title] AND translation [title] AND human.'

Gene	Title	PMID
RPL12	Phosphorylation of the Ribosomal Protein RPL12/uL11 Affects Translation during Mitosis	30220558

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000361436	130210615	130210702	In-frame
ENST00000361436	130211559	130211641	Frame-shift
ENST00000361436	130211888	130211987	In-frame

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000361436	130210615	130210702	650	381	467	165	97	126
ENST00000361436	130211888	130211987	650	200	298	165	37	70

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
P30050	97	126	1	165	Chain	ID=PRO_0000104456;Note=60S ribosomal protein L12
P30050	37	70	1	165	Chain	ID=PRO_0000104456;Note=60S ribosomal protein L12
P30050	37	70	38	38	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:16964243,ECO:0000244\|PubMed:18691976,ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:21406692,ECO:0000244\|PubMed:23186163;Dbxref=PMID:16964243,PMID:18691976,PMID:20068231,PMID:21406692,PMID:23186163
P30050	37	70	54	54	Modified residue	Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:19608861;Dbxref=PMID:19608861
P30050	37	70	40	40	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
P30050	37	70	38	70	Alternative sequence	ID=VSP_034695;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
PRAD	RPL12	1.03140367520778	0.0008447947014615
BLCA	RPL12	-3.6124920986454	0.012359619140625
HNSC	RPL12	1.31949815918867	0.0149245594448075
KIRP	RPL12	-2.07599071662134	1.26352533698082e-05
BRCA	RPL12	-2.15215406494599	4.57396841975666e-06
THCA	RPL12	1.7343782363164	5.23308492993332e-06
KIRC	RPL12	-2.90541430500864	8.74519390827313e-10

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
CESC	RPL12	-0.035737682	0.010338965

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with RPL12 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
COAD	TSG	RPL12	GAS5	0.81336304	6.36E-79
COAD	TSG	RPL12	GNB2L1	0.823101638	2.36E-82
DLBC	Cell metabolism gene	RPL12	TIMM9	0.802754332	6.77E-12
DLBC	Cell metabolism gene	RPL12	NME2	0.80767489	4.01E-12
DLBC	Cell metabolism gene	RPL12	FAU	0.831688227	2.46E-13
DLBC	Cell metabolism gene	RPL12	SNRPD2	0.837509638	1.17E-13
DLBC	Cell metabolism gene	RPL12	PFDN5	0.842077567	6.39E-14
DLBC	CGC	RPL12	NACA	0.86507853	2.22E-15
DLBC	TF	RPL12	NME2	0.80767489	4.01E-12
DLBC	TSG	RPL12	GNB2L1	0.909083934	4.13E-19
KICH	TSG	RPL12	GAS5	0.811490242	1.78E-22
KIRP	Cell metabolism gene	RPL12	SNRPD2	0.819843634	1.00E-79
KIRP	Cell metabolism gene	RPL12	FAU	0.836465237	7.57E-86
KIRP	TSG	RPL12	GAS5	0.807842164	1.10E-75
KIRP	TSG	RPL12	GNB2L1	0.824185436	2.91E-81
LGG	Cell metabolism gene	RPL12	FAU	0.841846406	1.58E-143
LGG	TSG	RPL12	GNB2L1	0.860640518	7.05E-157
PAAD	Cell metabolism gene	RPL12	FAU	0.81070953	6.00E-44
PAAD	TSG	RPL12	GNB2L1	0.821443879	5.13E-46
PCPG	Cell metabolism gene	RPL12	PFDN5	0.806143636	5.03E-44
PCPG	TSG	RPL12	GNB2L1	0.865357442	2.11E-57
PRAD	Cell metabolism gene	RPL12	TIMM9	0.805981892	6.82E-127
PRAD	Cell metabolism gene	RPL12	FAU	0.819383318	1.55E-134
PRAD	CGC	RPL12	NACA	0.865911145	5.30E-167
PRAD	Epifactor	RPL12	FBL	0.802322242	6.58E-125
PRAD	TF	RPL12	ZNF581	0.805846519	8.09E-127
PRAD	TSG	RPL12	GAS5	0.868186657	6.78E-169
PRAD	TSG	RPL12	GNB2L1	0.900160205	5.96E-200
READ	TSG	RPL12	GAS5	0.847114475	4.83E-30
THCA	Cell metabolism gene	RPL12	FAU	0.801358604	2.60E-129
THCA	TSG	RPL12	GAS5	0.836023496	1.05E-150
THCA	TSG	RPL12	GNB2L1	0.85795543	5.08E-167
THYM	Cell metabolism gene	RPL12	EXOSC4	0.80011889	2.09E-28
THYM	Cell metabolism gene	RPL12	EBP	0.800974111	1.66E-28
THYM	Cell metabolism gene	RPL12	SRM	0.800976307	1.66E-28
THYM	Cell metabolism gene	RPL12	PSMB3	0.808056787	2.37E-29
THYM	Cell metabolism gene	RPL12	POLR2F	0.809411257	1.62E-29
THYM	Cell metabolism gene	RPL12	APRT	0.809723829	1.48E-29
THYM	Cell metabolism gene	RPL12	PSMB7	0.810537489	1.18E-29
THYM	Cell metabolism gene	RPL12	GEMIN6	0.811233077	9.65E-30
THYM	Cell metabolism gene	RPL12	TIMM13	0.812550544	6.61E-30
THYM	Cell metabolism gene	RPL12	NANS	0.81334544	5.25E-30
THYM	Cell metabolism gene	RPL12	ITPA	0.814039724	4.30E-30
THYM	Cell metabolism gene	RPL12	SLC27A5	0.81670854	1.96E-30
THYM	Cell metabolism gene	RPL12	DPM2	0.818663377	1.10E-30
THYM	Cell metabolism gene	RPL12	SSR2	0.819179491	9.41E-31
THYM	Cell metabolism gene	RPL12	POLR2I	0.820703595	5.95E-31
THYM	Cell metabolism gene	RPL12	TIMM50	0.82132682	4.92E-31
THYM	Cell metabolism gene	RPL12	POLR2H	0.823458277	2.56E-31
THYM	Cell metabolism gene	RPL12	HMBS	0.834035196	8.79E-33
THYM	Cell metabolism gene	RPL12	EXOSC5	0.837622577	2.65E-33
THYM	Cell metabolism gene	RPL12	SNRPD2	0.840084277	1.15E-33
THYM	Cell metabolism gene	RPL12	TIMM8B	0.843820461	3.12E-34
THYM	Cell metabolism gene	RPL12	PGLS	0.846423805	1.24E-34
THYM	Cell metabolism gene	RPL12	PFDN5	0.858859943	1.15E-36
THYM	Cell metabolism gene	RPL12	FAU	0.898867009	8.13E-45
THYM	Epifactor	RPL12	EXOSC4	0.80011889	2.09E-28
THYM	Epifactor	RPL12	ZNHIT1	0.806234461	3.95E-29
THYM	Epifactor	RPL12	INO80E	0.810541688	1.18E-29
THYM	Epifactor	RPL12	SIRT6	0.827309508	7.71E-32
THYM	Epifactor	RPL12	BRMS1	0.834045437	8.76E-33
THYM	Epifactor	RPL12	EXOSC5	0.837622577	2.65E-33
THYM	Epifactor	RPL12	TAF10	0.852902132	1.14E-35
THYM	Epifactor	RPL12	FBL	0.864203701	1.34E-37
THYM	IUPHAR	RPL12	SLC27A5	0.81670854	1.96E-30
THYM	IUPHAR	RPL12	SIRT6	0.827309508	7.71E-32
THYM	TF	RPL12	ZBTB48	0.80052675	1.88E-28
THYM	TF	RPL12	ZNF787	0.804401384	6.55E-29
THYM	TF	RPL12	ZNF581	0.854080119	7.30E-36
THYM	TSG	RPL12	ZBTB48	0.80052675	1.88E-28
THYM	TSG	RPL12	NPRL2	0.805285615	5.13E-29
THYM	TSG	RPL12	GLTSCR2	0.825519491	1.35E-31
THYM	TSG	RPL12	SIRT6	0.827309508	7.71E-32
THYM	TSG	RPL12	BRMS1	0.834045437	8.76E-33
THYM	TSG	RPL12	GNB2L1	0.837468057	2.80E-33
THYM	TSG	RPL12	GADD45GIP1	0.840801976	8.95E-34
UCS	Cell metabolism gene	RPL12	EXOSC4	0.80011889	2.09E-28
UCS	Cell metabolism gene	RPL12	EBP	0.800974111	1.66E-28
UCS	Cell metabolism gene	RPL12	SRM	0.800976307	1.66E-28
UCS	Cell metabolism gene	RPL12	PSMB3	0.808056787	2.37E-29
UCS	Cell metabolism gene	RPL12	POLR2F	0.809411257	1.62E-29
UCS	Cell metabolism gene	RPL12	APRT	0.809723829	1.48E-29
UCS	Cell metabolism gene	RPL12	PSMB7	0.810537489	1.18E-29
UCS	Cell metabolism gene	RPL12	GEMIN6	0.811233077	9.65E-30
UCS	Cell metabolism gene	RPL12	TIMM13	0.812550544	6.61E-30
UCS	Cell metabolism gene	RPL12	NANS	0.81334544	5.25E-30
UCS	Cell metabolism gene	RPL12	ITPA	0.814039724	4.30E-30
UCS	Cell metabolism gene	RPL12	SLC27A5	0.81670854	1.96E-30
UCS	Cell metabolism gene	RPL12	DPM2	0.818663377	1.10E-30
UCS	Cell metabolism gene	RPL12	SSR2	0.819179491	9.41E-31
UCS	Cell metabolism gene	RPL12	POLR2I	0.820703595	5.95E-31
UCS	Cell metabolism gene	RPL12	TIMM50	0.82132682	4.92E-31
UCS	Cell metabolism gene	RPL12	POLR2H	0.823458277	2.56E-31
UCS	Cell metabolism gene	RPL12	HMBS	0.834035196	8.79E-33
UCS	Cell metabolism gene	RPL12	EXOSC5	0.837622577	2.65E-33
UCS	Cell metabolism gene	RPL12	SNRPD2	0.840084277	1.15E-33
UCS	Cell metabolism gene	RPL12	TIMM8B	0.843820461	3.12E-34
UCS	Cell metabolism gene	RPL12	PGLS	0.846423805	1.24E-34
UCS	Cell metabolism gene	RPL12	PFDN5	0.858859943	1.15E-36
UCS	Cell metabolism gene	RPL12	FAU	0.898867009	8.13E-45
UCS	Epifactor	RPL12	EXOSC4	0.80011889	2.09E-28
UCS	Epifactor	RPL12	ZNHIT1	0.806234461	3.95E-29
UCS	Epifactor	RPL12	INO80E	0.810541688	1.18E-29
UCS	Epifactor	RPL12	SIRT6	0.827309508	7.71E-32
UCS	Epifactor	RPL12	BRMS1	0.834045437	8.76E-33
UCS	Epifactor	RPL12	EXOSC5	0.837622577	2.65E-33
UCS	Epifactor	RPL12	TAF10	0.852902132	1.14E-35
UCS	Epifactor	RPL12	FBL	0.864203701	1.34E-37
UCS	IUPHAR	RPL12	SLC27A5	0.81670854	1.96E-30
UCS	IUPHAR	RPL12	SIRT6	0.827309508	7.71E-32
UCS	TF	RPL12	ZBTB48	0.80052675	1.88E-28
UCS	TF	RPL12	ZNF787	0.804401384	6.55E-29
UCS	TF	RPL12	ZNF581	0.854080119	7.30E-36
UCS	TSG	RPL12	ZBTB48	0.80052675	1.88E-28
UCS	TSG	RPL12	NPRL2	0.805285615	5.13E-29
UCS	TSG	RPL12	GLTSCR2	0.825519491	1.35E-31
UCS	TSG	RPL12	SIRT6	0.827309508	7.71E-32
UCS	TSG	RPL12	BRMS1	0.834045437	8.76E-33
UCS	TSG	RPL12	GNB2L1	0.837468057	2.80E-33
UCS	TSG	RPL12	GADD45GIP1	0.840801976	8.95E-34
UVM	Cell metabolism gene	RPL12	POLR1E	0.802359622	3.67E-19
UVM	Cell metabolism gene	RPL12	FAU	0.826159993	3.99E-21
UVM	CGC	RPL12	NACA	0.880291094	5.62E-27
UVM	Epifactor	RPL12	FBL	0.856252184	4.40E-24
UVM	IUPHAR	RPL12	LETMD1	0.809622135	9.87E-20
UVM	TF	RPL12	REXO4	0.821507651	1.02E-20
UVM	TSG	RPL12	GNB2L1	0.878271188	1.04E-26
UVM	TSG	RPL12	GLTSCR2	0.889168709	3.31E-28

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KIRP	RPL12	RPL18A	-1.51651392808885	0.00016188295558095
KICH	RPL12	RPS27A	1.75396693785956	0.000187873840332031
KIRP	RPL12	RPS16	-1.35957043617517	0.00019507110118866
COAD	RPL12	RPS3	1.48730375143014	0.000411599874496461
KIRP	RPL12	RPS11	-1.01861570565103	0.00105937570333481
LIHC	RPL12	RPL8	-4.84588284974558	0.00110314154326131
PRAD	RPL12	RPL18A	1.40600175748499	0.00205137828390396
KICH	RPL12	RPL19	1.36901182894089	0.00250792503356934
KICH	RPL12	RPS12	1.26997381758431	0.00308787822723389
LUAD	RPL12	RPL19	-1.31398026615725	0.00993159558412698
THCA	RPL12	RPS16	-6.16322798156577	0.0115764821363307
BLCA	RPL12	RPS12	-1.47804673440421	0.0204124450683594
BLCA	RPL12	RPS27A	-1.04747470069188	0.0258216857910156
HNSC	RPL12	RPS3	-4.73505819095135	0.0273726439852453
COAD	RPL12	RPS11	1.35307548998204	0.0312207043170929
LUSC	RPL12	RPL19	-2.14669889516666	0.044366810398747
KIRC	RPL12	RPL19	-2.73485271276676	1.33980982873695e-10
BRCA	RPL12	RPS12	-4.91239327478244	1.85340619742495e-09
KIRP	RPL12	RPL37	-1.17421621947139	2.26888805627823e-05
KIRC	RPL12	RPL35	-1.06475238059392	2.72286325678163e-08
KIRC	RPL12	RPL8	-1.18252459971773	5.64962994208288e-07
KIRP	RPL12	RPL8	-1.53003692350119	6.0301274061203e-05
KIRC	RPL12	RPS16	-1.66149869889384	7.8509870430991e-09
BRCA	RPL12	RPS27A	-4.28512148200424	7.8788217967112e-14
KIRC	RPL12	RPL37	-2.87198822058464	8.03913394748564e-12
KIRP	RPL12	RPL35	-1.52981101975496	9.0546440333128e-05
KIRC	RPL12	RPS3	-1.29560847926387	9.05905681935088e-10
KIRC	RPL12	RPL18A	-4.43079304960843	9.2516163152192e-11

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with RPL12

CBX1, Tuba1a, IPO11, CDC5L, NOP56, EBNA-LP, VHL, ARRB2, FBXO25, CUL3, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, CAND1, APP, RPL13, RPS16, RPS25, RPL10A, RPL11, RPL14, RPL15, RPL18A, RPL18, RPL19, RPL21, RPL23, RPL24, RPL27, RPL30, RPL31, RPL37A, RPL3, RPL4, RPL5, RPL6, RPL7A, RPL7, RPL9, RPS11, RPS13, RPS15A, RPS19, RPS20, RPS23, RPS24, RPS2, RPS3A, RPS3, RPS4X, RPS5, RPS6, RPS8, RPS9, RPSA, RPL8, RPS26, RPL10, RPL27A, RPL23A, RPS17, RPS28, RPS12, RPLP1, RPL22, RPL17, RPL29, RPL32, RPS21, EEF2, EEF1A1, ILF3, HNRNPU, HNRNPM, TUFM, NAP1L1, RPS27L, MRPL12, RPLP0P6, RPL10L, S100A10, STK24, ACP1, CTR9, ESR1, PAXIP1, UBC, PA2G4, FN1, VCAM1, TP63, UBL4A, ITGA4, PAN2, CD81, IGSF8, ICAM1, TARDBP, PARK2, AURKA, CEP250, TP53, HUWE1, FUS, CUL7, OBSL1, EED, LGALS3, GNB2L1, DHX15, EEF1A2, FAU, MRPL1, MRPL22, NHP2L1, RPL13A, RPL26L1, RPL34, RPL35, RPL35A, RPL36, RPLP0, RPLP2, RPS10, RPS14, LOC101929876, RPS27, RPS7, RPL38, RPS18, STK25, STK26, MLLT1, PTEN, EWSR1, CNOT2, VIM, AKAP1, Eif3e, Rrbp1, SKI, MCM2, Ksr1, RC3H1, CNBP, ZC3HAV1, MECP2, KIAA0020, NCL, CYLD, INO80B, COX15, DLD, DNM1L, PDHA1, SDHA, VDAC1, TRIM25, UBE2A, HEY1, BRCA1, DDX39B, HSPA8, TMPO, ACO2, API5, CTNNB1, KRAS, LARS, BCL2L1, BMP4, COPE, JUP, MED12, PCBP1, PPIE, TGFB1, UBE2L6, YAP1, PRPF8, EFTUD2, AAR2, PIH1D1, TNIP2, CHD3, CHD4, TNF, CDC34, SPDL1, RIOK1, HEXIM1, MEPCE, LARP7, RNF123, PPT1, SNAI1, AGR2, RECQL4, DCPS, GPC1, REST, MYC, Prkaa1, Prkab1, RPS6KB2, GRWD1, KRT17, METTL14, KIAA1429, RC3H2, ACTC1, PHB, RBX1, KIN, USP14, NR2C2, PPP1CC, VRK1, VRK3, HIST1H4A, SNRNP70, ITFG1, ARAF, HMGB1, PPP1CA, BIRC3, NFX1, WWP2, Dnajc17, SOX2, CMTR1, OR10G4, ARIH2, PLEKHA4, PINK1, TFCP2, FANCD2, HCVgp1, ZC3H18, CDC42, GRB7, NCK1, PTPN6, RAB5A, C1D, PRDX2, E, M, nsp13, nsp4, nsp5, nsp6, ORF3a, ORF6, ORF7a, ORF7b, TTN, NEK4, DUX4, CIT, ANLN, AURKB, CHMP4B, ECT2, KIF14, KIF20A, KIF23, PRC1, GRSF1, LRRC59, INS, Rnf183, BRD4, Apc2, RBM39, FBP1, INSIG1, RIN3, DNAJC2, DNAJC1, OGT, BAG5, UFL1, DDRGK1, TRIM37, HTRA4, FZR1, WDR5, PAGE4, NUDCD2, NAA40, PRKRA, ADARB1, MAGEB10, LLPH, ZNF668, HIST1H1A, HIST1H1E, SRSF6, MAGEB2, NPM3, DTX3, SPRTN, BTF3, FBXW7, RCHY1, SQSTM1, OPTN, SIRT6,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
RPL12	KIRP	chr9	130213582	130213582	G	A	Silent	p.F5F	4
RPL12	UCEC	chr9	130211898	130211898	T	C	Silent	p.R67	2
RPL12	UCEC	chr9	130211949	130211949	C	T	Silent	p.T50	2
RPL12	SKCM	chr9	130210242	130210242	C	T	Missense_Mutation	p.A136T	2
RPL12	STAD	chr9	130211929	130211929	C	T	Missense_Mutation	p.R57K	2
RPL12	STAD	chr9	130211589	130211589	G	-	Frame_Shift_Del	p.P88fs	2
RPL12	STAD	chr9	130210644	130210644	C	T	Silent	p.R117R	2
RPL12	KIRC	chr9	130211560	130211571	TGTTTTTCTGTT	-	Splice_Site	p.KQKNI94_splice	2
RPL12	BLCA	chr9	130210620	130210620	G	C	Silent	p.L125L	2
RPL12	COAD	chr9	130210156	130210156	G	A	Silent	p.A164A	1
RPL12	KIRP	chr9	130213582	130213582	G	A	Silent		1
RPL12	THCA	chr9	130213590	130213590	G	A	Missense_Mutation	p.P3S	1
RPL12	COAD	chr9	130211976	130211976	T	-	Frame_Shift_Del	p.V42fs	1
RPL12	PAAD	chr9	130213570	130213570	C	A	Missense_Mutation	p.E9D	1
RPL12	ESCA	chr9	130210016	130210017	-	A	RNA	NULL	1
RPL12	SARC	chr9	130213050	130213050	G	T	Missense_Mutation		1
RPL12	ESCA	chr9	130212812	130212812	A	G	RNA	NULL	1
RPL12	SARC	chr9	130210073	130210073	T	C	RNA	NULL	1
RPL12	ESCA	chr9	130213127	130213127	A	T	RNA	NULL	1
RPL12	HNSC	chr9	130210254	130210255	TC	-	Frame_Shift_Del		1
RPL12	SKCM	chr9	130210655	130210655	G	A	Nonsense_Mutation	p.R114*	1
RPL12	HNSC	chr9	130210254	130210255	TC	-	Frame_Shift_Del	p.EI131fs	1
RPL12	HNSC	chr9	130210254	130210255	TC	-	Frame_Shift_Del	p.E131fs	1
RPL12	KIRC	chr9	130211560	130211571	TGTTTTTCTGTT	-	Frame_Shift_Del	p.94_98del	1
RPL12	BLCA	chr9	130210620	130210620	G	C	Silent		1
RPL12	STAD	chr9	130210270	130210270	T	C	Splice_Site	p.G127_splice	1
RPL12	THCA	chr9	130213590	130213590	G	A	Missense_Mutation		1

Copy number variation (CNV) of RPL12
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Fusion gene breakpoints (product of the structural variants (SVs)) across RPL12
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Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
85164	STAD	TCGA-CD-8527-01A	AGRN	chr1	957842	+	RPL12	chr9	130210702	-
85164	STAD	TCGA-BR-8284-01A	CPSF6	chr12	69656342	+	RPL12	chr9	130210702	-
85164	N/A	AA503668	CRIP3	chr6	43277969	-	RPL12	chr9	130209955	+
85164	N/A	AI826359	CRIP3	chr6	43277969	-	RPL12	chr9	130209956	+
85164	N/A	EC522587	DDX59	chr1	200635676	-	RPL12	chr9	130213665	-
85164	N/A	BF089907	IKZF3	chr17	37921309	-	RPL12	chr9	130210198	-
85164	N/A	AA748119	NBEAL1	chr2	204056042	+	RPL12	chr9	130210702	-
85164	N/A	AK098493	PACS1	chr11	65898182	+	RPL12	chr9	130211626	-
75860	N/A	BF337185	RPL12	chr9	130209958	-	CRIP3	chr6	43277969	+
75860	N/A	BI861321	RPL12	chr9	130209959	-	CRIP3	chr6	43277969	+
75860	N/A	BM016120	RPL12	chr9	130209955	-	CRIP3	chr6	43277969	+
75860	N/A	DT217240	RPL12	chr9	130209956	-	CRIP3	chr6	43277969	+
77753	COAD	TCGA-CM-4746-01A	RPL12	chr9	130210161	-	FAM159B	chr5	63986325	+
77698	COAD	TCGA-AD-6889-01A	RPL12	chr9	130211560	-	GAS5	chr1	173833842	-
75860	N/A	AV698166	RPL12	chr9	130211566	-	IGKC	chr2	89157109	-
78463	N/A	AA642624	RPL12	chr9	130211987	+	NBEAL1	chr2	204056042	-
78463	N/A	AA730292	RPL12	chr9	130211988	+	NBEAL1	chr2	204056042	-
99812	N/A	BI861341	RPL12	chr9	130209961	-	RIN2	chr20	19804527	-
85164	N/A	AA559856	RPL12	chr9	130209993	-	RPL12	chr9	130209965	+
85164	N/A	AW277039	RPL12	chr9	130213673	+	RPL12	chr9	130213594	-
75860	N/A	BI856866	RPL12	chr9	130209953	-	RPL12P38	chr17	58511644	-
95193	N/A	BG230781	RPL12	chr9	130211612	-	TTC6	chr14	38105459	-
85164	N/A	BG222233	SLCO5A1	chr8	70602408	-	RPL12	chr9	130211606	-
85165	N/A	AA036700	SON	chr21	34926623	+	RPL12	chr9	130211621	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
SARC	RPL12	0.0424755430366492	1
BRCA	RPL12	0.0467940975841295	1
LGG	RPL12	0.0489009044343929	1

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUSC	RPL12	0.000932063953258191	0.031
BRCA	RPL12	0.0297480282094036	0.92
PAAD	RPL12	0.0201508211219238	0.64
THYM	RPL12	0.0369256779757217	1

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0376358	Malignant neoplasm of prostate	1	CTD_human